ライフサイエンスコーパス: determinant

1 wing that strand separation is a specificity determinant.

2 nd Pel may therefore be a widespread biofilm determinant.

3 (SLF) genes collectively encoding the pollen determinant.

4 , KL51 capsule, and yersiniabactin virulence determinants.

5 pers the characterization of specific glycan determinants.

6 ty to allergens, autoantigens and microbiome determinants.

7 e mechanism for biased delivery of cell fate determinants.

8 at shared intrinsic properties are apoptotic determinants.

9 ease in macrolide and sulfonamide resistance determinants.

10 assess their incidence and to analyze their determinants.

11 ion of genes encoding important colonization determinants.

12 emerged earlier, but showcased sporadic AMR determinant acquisition largely after 1960, including ac

13 eterminants for binding to ProQ and negative determinants against binding to Hfq.

14 This article highlights social determinants already included in USPSTF recommendations

15 , which contains S-RNase encoding the pistil determinant and 16-20 S-locus F-box (SLF) genes collecti

16 stigations should prospectively focus on the determinants and health consequences of SPD attributable

17 sion assessed the association between social determinants and MELD at removal for "too sick." RESULTS

18 need for high-quality, up-to-date data on TB determinants and outcomes.

19 g a multimodal analytical approach to reveal determinants and predictors of immunity, susceptibility

20 We aimed to characterize mechanistic determinants and prognostic implications of VE/VCO2 in a

21 CR4-CXCL12 complex pinpoints the interaction determinants and reveals the occupancy of the receptor m

22 monstrated QS-dependent control of virulence determinants and virulence in several human pathogenic b

23 Interestingly, ABO(H) determinants are also expressed on several different pla

24 ABO(H) blood group determinants are expressed on different glycoproteins on

25 These specificity determinants are held in a structural framework comprisi

26 Parkinson's disease (PD), but its molecular determinants are unknown.

27 tions governing tumor immunity and molecular determinants associated with clinical benefit from ICI t

28 , yet they lack expression of many virulence determinants associated with the pathogenicity of wild-t

29 While social determinants at the patient and system level are associa

30 Antibody to antigenic determinant binding was associated with time of exposure

31 er and is unique in utilising C34 as an anti-determinant by studying the contributions of individual

32 Here, we describe the cytoskeletal determinant CcfM (curvature-inducing coiled-coil filamen

33 These findings uncover molecular determinants critical for agonist binding and biased sig

34 otrusion in the envelope V3 loop, this viral determinant does not directly influence V3 loop bnAb sen

35 defined for a few model LPMOs, the molecular determinants driving broad substrate specificity are sti

36 rensis, biotin biosynthesis is a key fitness determinant during infection(2-5), making it a high-prio

37 tter determine the relevant microcirculation determinants during venoarterial extracorporeal membrane

38 igher-order conformation, and the structural determinants essential to membrane permeabilization, rem

39 up-regulates both cellular and phytohormonal determinants, followed by intrinsic hypersensitive respo

40 oxicity exerted by APAP metabolites is a key determinant for early hepatocytes injury, the recruitmen

41 cells in the tumor microenvironment is a key determinant for effective antitumor immunity and immunot

42 ntation within the UDCA-HDAC6i structure was determinant for HDAC6i activity and selectivity.

43 he trafficking protein SNX1 may be a crucial determinant for hypertension and response to antihyperte

44 age status of the prostate cancer cells is a determinant for its propensity to exhibit lineage plasti

45 a identify the Ig-like domain as the primary determinant for N-MADD-4B interaction with NLG-1 in vitr

46 Breech presentation was the strongest determinant for PCS as well as PPCS.

47 d exchange and homolog pairing as a critical determinant for recombination outcome.

48 rather than DSB efficiency, was the primary determinant for successful HR.

49 re, we found that chronic inflammation was a determinant for the competitive advantage of MDS HSPCs a

50 int to axoplasmic Ca(2+) concentrations as a determinant for the temporal specificity of sequential t

51 oters, as well as a polythymidylate sequence determinant for transcription termination.

52 t this approach to more reliably predict AMR determinants for a wider range of microbial pathogens.

53 V morphology and dysfunction are independent determinants for ascending aorta dilatation in pediatric

54 . coli ProQ and Hfq depends both on positive determinants for binding to ProQ and negative determinan

55 an incomplete understanding of the antigenic determinants for DENV type-specific (TS) antibodies, esp

56 binding mode of WIN 55,212-2 and structural determinants for distinguishing CB2 agonists from antago

57 cs data can help identify critical molecular determinants for effective targeted therapeutics.

58 somal contacts of a DSB site are the primary determinants for gammaH2Ax landscapes.

59 findings define the positional and sequence determinants for initial-transcription pausing and estab

60 ngs provide novel insights into the cellular determinants for phagocytic recognition and uptake of P.

61 However, the structural determinants for tau-HS interaction are not well underst

62 Here, we set out to identify the determinants for the extended nephropathogenic tropism o

63 reased Env incorporation into virions as the determinants for the Nef- and CD3-dependent enhancement

64 data and national-level indicators of social determinants from 74 countries to examine change in sati

65 However, differing social determinants have been proposed by a wide range of agenc

66 Among survival determinants, improvements in early diagnosis and treatm

67 et tissues, organs, or cells is an important determinant in developing advanced nanobiosensor-based t

68 Infectivity is a critical determinant in informing public health guidelines/interv

69 level of alphaGln-242, a steroid sensitivity determinant in the alphaM1 helix.

70 disposition to proteome instability may be a determinant in the pathogenesis of paediatric brain canc

71 across the predialysis CKD spectrum to these determinants in age- and CKD stage-matched patients, wit

72 tamases (SBLs) are key antibiotic resistance determinants in Gram-negative bacteria.

73 ze this fascinating collection of resistance determinants in Listeria, with special focus on resistan

74 f are involved in recruiting Cul5, different determinants in the MVV Vif are required for cofactor bi

75 On adjusted analysis, social determinants including age, race, sex, and education pre

76 sembly as well as insight into the energetic determinants involved in templating amyloid assembly.

77 nt form, DSR-OKDelta1, to identify molecular determinants involved in the sugar polymerization mechan

78 ty to infer the relative importance of these determinants is limited, particularly for dispersal abil

79 egate level data on social and environmental determinants is necessary to develop effective outbreak

80 nine proteins, called iron-regulated surface determinants (Isds).

81 In ascidian zygotes, maternal determinants (mRNAs) are first transported to the vegeta

82 the presence of predominant nonneutralizing determinants (nND) on Env may impede the elicitation of

83 early ADC can be predicted based on genomic determinants.Objectives: To identify genomic alterations

84 We observe that INVS is the core structural determinant of a compartment composed of novel fibril-li

85 the overall occupancy of TFs is the primary determinant of activity.

86 ces the concept that peptide length is a key determinant of Ag specificity in CD8(+) T cell responses

87 neural stem cell (NSC) quiescence is a major determinant of age-related regenerative decline in the a

88 accessibility of food allergens may be a key determinant of allergic reactions.

89 nking the homeodomain that serves as a major determinant of ancestral activity.

90 cted to cause reductions in body size, a key determinant of animal physiology and ecology.

91 etylglucosamine (PNAG) is a major structural determinant of bacterial biofilms responsible for persis

92 of beta-cell L-type Ca(V) channels is a key determinant of beta-cell glucose-stimulated Ca(2+) entry

93 current insights into the roles of PGN as a determinant of brain inflammation, notably in multiple s

94 ing and neutralizing TcdB toxin, the primary determinant of C. difficile disease.

95 nactivation of RyR2 by Ca(2+)-CaM is a major determinant of Ca(2+) alternans, making Ca(2+)-CaM depen

96 s, of aberrant metabolism as an aetiological determinant of cancer.

97 e that trabecular morphology is an important determinant of cardiac performance.

98 activation, and in heart failure is a major determinant of cardiac physiology and pathophysiology.

99 ronic unresolved inflammation is the primary determinant of cardiovascular disease.

100 The aortic valve is an important determinant of cardiovascular physiology and anatomic lo

101 Gene expression is a key determinant of cellular response.

102 ng normocapnia (P < 0.0001) and was the sole determinant of changes in the CBFV response, resulting f

103 Myocardial fibrosis is a major determinant of clinical outcomes in heart failure (HF) p

104 o its correlated noise patterns is a greater determinant of coding accuracy than is absolute noise st

105 ggests that delivery systems are one primary determinant of costs and outcomes of most interventions,

106 Photosynthesis is the primary determinant of crop productivity and any gain in photosy

107 Here, we demonstrate a simple, yet robust, determinant of developmental potential-the number of exp

108 hat Rap1 carried by MetS-lEVs may be a novel determinant of diagnostic value for cardiometabolic risk

109 the recognition helix itself as an important determinant of DNA specificity and found protein sequenc

110 in hypertrophic cardiomyopathy, and a major determinant of dynamic left ventricular outflow tract (L

111 We conclude that glucose is a key determinant of endothelial function.

112 Recognising activity as a determinant of energetic status, the predictability of a

113 veal that extracellular serine is a critical determinant of EpdSC fate and provide insight into how n

114 tive impairment, which is considered a major determinant of functional outcome.

115 We hypothesized that the primary determinant of GCH in ever smokers with or without airfl

116 Epigenetic regulation is a key determinant of gene expression in sepsis.

117 The outer membrane is a key virulence determinant of gram-negative bacteria.

118 Here we show that the key determinant of Grx function is a distinct loop structure

119 Infection control is a major determinant of guided tissue regeneration (GTR).

120 any aspects of its host biology and is a key determinant of health and disease.

121 is broad agreement that religion is a social determinant of health.

122 or recognition by the S protein is the major determinant of host range, tissue tropism, and pathogene

123 the first step of viral infection and a key determinant of host specificity.

124 n vivo contributions of VacA as an important determinant of Hp colonization and chronic infection rem

125 ultiple immune-mediated diseases are a major determinant of interindividual variability in pattern-re

126 receptor and that its flexibility is a major determinant of its interactions with these two downstrea

127 Jaw-muscle architecture is a key determinant of jaw movements and bite force.

128 ion of the central stalk as a key mechanical determinant of kinesin-14 motility [3].

129 r layer," is identified as the more critical determinant of Li electrode performance.

130 be considered as a possible but not uncommon determinant of LV hypertrabeculation in asymptomatic sub

131 weeks onward, diet became the most important determinant of microbiota composition; cessation of brea

132 Thus, TRIM37 is an essential determinant of mitotic vulnerability to PLK4 inhibition.

133 nformation transfer about predators as a key determinant of mixed-species group formation, and that d

134 tients with NASH, liver fibrosis is the main determinant of mortality.

135 tum by the cortex and thalamus is a critical determinant of MSN activity and local regulation of dopa

136 The HIV-1 capsid is the key determinant of MxB sensitivity and cofactor binding defe

137 hat contains the EDTEE sequence as a general determinant of Nef responsiveness, but they further indi

138 unction of neuronal circuits is an important determinant of neurodegenerative diseases.

139 ndings de-orphanize GPR160, identify it as a determinant of neuropathic pain and potential therapeuti

140 oprotegerin (RANKL/OPG) ratio as the primary determinant of osteolytic activity, while a low RANKL/OP

141 ional recovery in the end target muscle is a determinant of outcome after peripheral nerve injury.

142 Climate is a primary determinant of plant growth in semi-arid ecosystems, yet

143 d, in part, by the activity of CETP, a major determinant of plasma HDL-C levels.

144 hypertension (PH) after PEA remains a major determinant of poor prognosis.

145 dent factors appear to be the most important determinant of post-injury alterations of gene expressio

146 Peak oxygen uptake, a primary determinant of prognosis, mortality and quality of life,

147 translation efficiency represents a primary determinant of protein levels during stimuli adaptation.

148 These findings identify MPO as a genetic determinant of pustular skin disease and neutrophil abun

149 ic state of the viral genome is an important determinant of reactivation that varies in a strain-spec

150 d composition of renal cells is an important determinant of renal function.

151 ical outcomes, but that this is not the sole determinant of response.

152 nces, potentially serving as a key molecular determinant of subtype-specific calcium signaling in IP(

153 t all eukaryotes and sensing oxygen is a key determinant of survival.

154 nse to environmental factors is an important determinant of the ability of the tumor cells to metasta

155 he lysine-binding site of K2(hPg) is a major determinant of the activation-resistant T-conformation o

156 ir incorporation to triacylglycerol might be determinant of the different composition of the seed oil

157 Cortical thinning was the primary determinant of the Expanded Disability Status Scale, whi

158 of microscale DMSP hotspots is an important determinant of the fate of sulfur in the ocean.

159 Tropical forests are a key determinant of the functioning of the Earth system, but

160 The quality of the environment is a major determinant of the health and well-being of a population

161 indicate that timing of stress is a critical determinant of the pathology produced in the adult: adol

162 attached to proteins represent an important determinant of the protein interaction-specificity and m

163 Here we assessed whether lower SES is a determinant of the rate of decline over 8 y in six domai

164 loop, rather than isthmus, is the principal determinant of the rate of VT.

165 RP2, our data implicate HPF1 as an important determinant of the response to clinical PARP inhibitors.

166 However, this model ignores a key determinant of the success of bacterial pathogens, adapt

167 uggest that potassium homeostasis is a major determinant of the tubular site of sodium retention in n

168 ellular metabolism has emerged as a critical determinant of the viability and function of both cancer

169 g presynaptic release sites is a fundamental determinant of their coactivation and of synaptic physio

170 Because sex is a determinant of these disorders but poorly understood, se

171 show that low intrinsic efficacy is a major determinant of these distortions, and pursuit of appropr

172 A key environmental determinant of this aggressiveness is the stromal ecolog

173 ctron transport chain activity as a critical determinant of this process, establishing metabolic repr

174 (S) protein and its receptor is the primary determinant of tissue and host specificity; however, vir

175 Spontaneous recovery is an important determinant of upper extremity recovery after stroke and

176 MERS-CoV), the spike (S) protein is the main determinant of viral entry.

177 l surface receptors by viruses is a critical determinant of viral tropism and disease.

178 factors has proven to be the most important determinant of VTE recurrence risk.

179 enome-wide mutagenesis to screen for genetic determinants of 2-OG levels, we uncover a redox sensitiv

180 While probing the nucleobase determinants of 5mC recognition, we discovered that TET

181 hotodissociation (UVPD) to map the antigenic determinants of a model antibody-antigen complex involvi

182 Our objective is to understand the molecular determinants of a progressive deterioration of functiona

183 devise strategies to overcome the modifiable determinants of adverse mental illness symptoms.

184 H) and CFH related genes (CFHR1-5) are major determinants of AMD susceptibility, but their molecular

185 lic health and the identification of genetic determinants of AMR is a critical component to epidemiol

186 kers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project were analyzed.

187 kers Reflecting Inflammation and Nutritional Determinants of Anemia project.

188 ngle narrowing by assessing ocular biometric determinants of anterior chamber angle width.

189 e-genome sequencing data to identify genetic determinants of antimicrobial resistance (AMR), but they

190 To understand the determinants of ARO colonization on NF admission, we app

191 e inflow artery is one of the most important determinants of arteriovenous fistula (AVF) success.

192 d in our appreciation of important metabolic determinants of bacterial physiology.

193 Thus, SD(ada) , SR and S(mes) are important determinants of C(4) -g(m) and could be the target trait

194 sparities between racial groups, within-race determinants of cardiovascular health among Black adults

195 nality and tissue localization are important determinants of CD8+ T cell-mediated efficacy against SI

196 ure age and culture density are much greater determinants of cell survival after exposure.

197 d to elucidate disease mechanisms and causal determinants of cell type-selective vulnerability and to

198 eactive oxygen species (ROS), and additional determinants of cellular health.

199 ardized mixed-methods framework for studying determinants of childhood stunting reduction applied in

200 However, the underlying genetic determinants of CHK1 inhibitor sensitivity remain unclea

201 mpirical study identifies the key urban form determinants of decadal-long fine particulate matter (PM

202 and parenchymal cells for identification of determinants of endothelial cell heterogeneity, and coul

203 puter simulations to investigate the primary determinants of fracture in disordered collagen networks

204 rp cell differentiation could help elucidate determinants of fruit cell fate maintenance.

205 entually allow us to delineate the molecular determinants of gating and ion permeation.

206 in insight into the molecular mechanisms and determinants of gene expression evolution in natural pop

207 A-encoded sequence elements serve as primary determinants of gene regulation in these organisms; howe

208 ries at high resolution, learns the sequence determinants of genome folding and predicts the impact o

209 tlisting persists after adjusting for social determinants of health (eg, cultural, psychosocial, and

210 clinical outcomes and whether adding social determinants of health (SDOH) into risk prediction model

211 imited information concerning whether social determinants of health affect postliver transplant (LT)

212 -based prevention recommendations for social determinants of health challenging.

213 Social determinants of health in the African diaspora drive the

214 tcomes, including individual factors, social determinants of health, and health delivery system facto

215 ter adjusting for medical factors and social determinants of health, suggesting the need to identify

216 and a lack of detailed information on social determinants of health.

217 governing sex work are considered structural determinants of HIV, individual-level data assessing thi

218 irus entry into host cells is one of the key determinants of host range and cell tropism and is subje

219 jective of gaining a better understanding of determinants of house dust Pb bioavailability.

220 +) T cell responses as potentially important determinants of immune protection in mild SARS-CoV-2 inf

221 The description of determinants of immunopathogenesis in TB is of tremendou

222 erable recent data establishes BETs as novel determinants of induced transcriptional programs in vasc

223 zi et al. help define the molecular and host determinants of influenza virus spillover from animal to

224 We compared the patterns and determinants of interprovincial spread of the five most

225 However, the molecular determinants of its catabolism are poorly understood.

226 s structural and functional studies, but the determinants of ligand binding, selectivity, and signali

227 , while intestinal conditions were the major determinants of lipolysis (f-ratio = 58.01).

228 protein synthesis and autophagy are critical determinants of LRRK2 neurodegeneration, opening up poss

229 eptor Neuropilin-1 (Nrp-1) emerge as crucial determinants of MCMV infection.

230 leotide-sensitive HCN4 channels are critical determinants of membrane excitability in cells throughou

231 effects, while climatic factors are stronger determinants of microbiomes on host external surfaces.

232 We assessed and compared determinants of mineral homeostasis in patients with nep

233 -temporal features of these signals were key determinants of model outcome, in addition to the actual

234 Thus, BH sites are important determinants of motor targeting and may have a similar r

235 understanding of the molecular and cellular determinants of nerve regeneration and neuropathic pain

236 sity and distribution of clinically relevant determinants of pathogenicity and antimicrobial resistan

237 Identifying the cis-determinants of poly(A) signal (PAS) on the DNA sequence

238 ated a bioinformatic pipeline to isolate key determinants of polyreactivity.

239 ients determine their own personal goals and determinants of quality of life that are independent of

240 climatological drivers for Arctic warming as determinants of range expansion for two temperature-depe

241 process-based approach to understanding the determinants of range limits.

242 Biophysical determinants of recognition specificity are poorly under

243 These findings provide insight into the determinants of response to combined PD-1/PD-L1 and angi

244 models were employed to identify functional determinants of response to pharmacologic CDK4/6 inhibit

245 hages and PD-L1 + tumor cells as mechanistic determinants of response.

246 We identify two determinants of response; mutational signature 3 reflect

247 , and previously identified social cognitive determinants of retinal screening.

248 While sequence determinants of S1 affinity and many elements of the int

249 enopus laevisoocytes to functionally map the determinants of S4 helix motion during voltage-dependent

250 To elucidate the molecular determinants of SAM domain function in SAMD14, we substi

251 Here, we decipher the molecular determinants of selectivity of the closely related ComRS

252 Important patient clinical determinants of self-care included cognitive status, num

253 Our findings elucidate the molecular determinants of severe UTI and have implications for the

254 To the extent that these determinants of sleep health are modifiable, sleep and p

255 Our findings support a model whereby genetic determinants of smoking increase type 2 diabetes risk in

256 stion by constructing data on the levels and determinants of social mobility across American regions

257 identifies major demographic and functional determinants of species' niches and geographic distribut

258 We predicted genetic determinants of stroke would be more prominent in this g

259 onal protein design (CPD) aim to capture the determinants of structure from physical principles.

260 function status, and CVD events were the key determinants of subsequent morbidity and mortality.

261 Here, we unravel the biophysical determinants of supralinear Ca(2+) signals associated wi

262 factors, as a group of molecules, are potent determinants of synaptic partner choice and therefore ul

263 biosphere, atmosphere and geosphere are key determinants of terrestrial ecosystem functioning.

264 ain potassium channels (K(2P)) are the major determinants of the background potassium conductance.

265 of ascites, albumin and hemoglobin are major determinants of the development of early ascites post-DE

266 hromatin-remodeling factors appear to be key determinants of the emergence and survival of ALT cancer

267 tracking and understanding the patterns and determinants of the global spread of SARS-CoV-2.

268 Given thrombotic complications are central determinants of the high mortality rate in COVID-19, str

269 Ca(2+) ATPase (SERCA) pump is one of the key determinants of the phenotypes seen in various muscle ti

270 This study aimed to analyze the determinants of the rate of human VT with comparison of

271 we characterized the structural and sequence determinants of these activities.

272 The determinants of this process are unknown.

273 providing a platform for identifying the key determinants of this process.

274 These results reveal the structural determinants of tip-link-mediated inner-ear sensory perc

275 e quantitative insights into the topological determinants of transcriptional control and tissue-speci

276 We studied genetic determinants of urine 6-bromotryptophan and its associat

277 This article aims to assess fundamental determinants of use of biologic medicines in sub-Saharan

278 t across the transcriptome and the molecular determinants of variability therefore remain poorly defi

279 Here, we identify two strain-specific determinants of ZIKV virulence in mice.

280 Here, we identify two strain-specific determinants of ZIKV virulence that are evident in only

281 can affect one or more functional antigenic determinants on the HPV capsid.

282 pret microarray data and identify structural determinants promoting glycan binding to glycan-binding

283 rface expression of Tim-3, but the molecular determinants remain poorly understood.

284 The structure reveals that the RVC20 binding determinants reside in a highly conserved surface of G,

285 n the MOP receptor, as well as the molecular determinants responsible for its positive allosteric mod

286 Sequence overlap may thereby play a determinant role in enhancer function and evolution.

287 during CD4+ T cell-initiated EAE engaged in determinant spreading and influenced disease.

288 indicating TMD flexibility as a mechanistic determinant that facilitates transmitter release from di

289 The genetic determinants that control the entrance into the myogenic

290 multiple human cell lines to highlight viral determinants that could contribute to H5N1 virus pathoge

291 ave been resolved that begin to identify the determinants that define grass cell walls.

292 I and II on membranes elucidated structural determinants that enable them to bind membranes.

293 licated in PD-ICBs and identify psychosocial determinants that may perpetuate the cycle of impulsive

294 induced PML pathogenesis is needed to define determinants that predispose patients to PML, a goal who

295 SNs and MNs are regulated by a common set of determinants, thus linking early rostrocaudal patterning

296 med to quantify this risk and the associated determinants using an individual patient data meta-analy

297 Here, to shed light on their functional determinants, we seek to exploit the evolutionary record

298 These determinants were resolved further by site-directed muta

299 gD revealed that the gI ECD is the critical determinant, whereas the transmembrane domain served mer

300 These determinants, which include an increase in inter-loop cr