ライフサイエンスコーパス: deubiquitinase

1 PTEN influences its stability through OTUD3 deubiquitinase.

2 ts commonalities among distantly related OTU deubiquitinases.

3 o form of USP7, which differs from other USP deubiquitinases.

4 ubiquitin-specific protease (USP) family of deubiquitinases.

5 ith concomitantly reduced affinity for other deubiquitinases.

6 tin linkage specificities of these bacterial deubiquitinases.

7 and extremely selective for USP7 over other deubiquitinases.

8 tination signaling, including E3 ligases and deubiquitinases.

9 e the conformational properties of the human deubiquitinase A (DUBA), a negative regulator of type I

10 PTEN, the signaling inhibitor SOCS1 and the deubiquitinase A20.

11 In mammals, ~100 deubiquitinases act on ~20,000 intracellular ubiquitinat

12 e depending on opposing ubiquitin ligase and deubiquitinase activities.

13 ying complex possesses acetyltransferase and deubiquitinase activities.

14 r phosphorylation directly regulates VCIP135 deubiquitinase activity and Golgi membrane fusion in the

15 which is accompanied by the recovery of its deubiquitinase activity and Golgi reassembly.

16 dies reveal molecular mechanisms whereby A20 deubiquitinase activity and ubiquitin binding, linear ub

17 ion-impaired (S333A) USP20 possess intrinsic deubiquitinase activity equivalent to WT activity.

18 The PCP domain was shown to have deubiquitinase activity for both RIG-I and TBK-1, whose

19 o underscores the biological significance of deubiquitinase activity in MSC function.

20 y reported effectors, such as the unexpected deubiquitinase activity in Xanthomonas XopD, contributed

21 d's incorporation into the proteasome, Rpn11 deubiquitinase activity is inhibited to prevent unwarran

22 ermore, small-molecule inhibitors of HAUSP's deubiquitinase activity markedly suppress the growth of

23 This interaction allows the deubiquitinase activity of ataxin 3 to protect beclin 1

24 exhibited significantly increased lysine 63 deubiquitinase activity relative to the wild-type enzyme

25 n this modular complex, Ataxin-7 anchors the deubiquitinase activity to the larger complex.

26 we found that MavC itself also exhibits weak deubiquitinase activity towards this non-canonical ubiqu

27 8R) in a case that completely abolished BAP1 deubiquitinase activity was identified.

28 A small-molecule inhibitor of STAMBP deubiquitinase activity, BC-1471, decreases NALP7 protei

29 gative regulator of NF-kappaB signaling with deubiquitinase activity, is highly expressed in label-re

30 GE mobility shift of the protein, blocks its deubiquitinase activity, promotes its dissociation from

31 on for the H4 basic patch in regulating SAGA deubiquitinase activity, we also detected increased SAGA

32 bilities, as well as RNase activity, but not deubiquitinase activity, which impaired the inhibitory a

33 uate ubiquitin binding and thus inhibit USP7 deubiquitinase activity.

34 A20 restricts NF-kappaB signals via its deubiquitinase activity.

35 two juxtaposed helices critical to ataxin-3 deubiquitinase activity.

36 is caused by mutations that lead to reduced deubiquitinase activity.

37 into the proteasome as well as a C-terminal deubiquitinase adaptor (DEUBAD) domain that binds the de

38 was examined and it was discovered that some deubiquitinases also possess derubylase activity.

39 omains of prokaryotic origin within the MPND deubiquitinase and ASXL1, a component of the Polycomb re

40 CYLD encodes a lysine 63 deubiquitinase and CYLD cutaneous syndrome, a skin tumou

41 y obstacle in delineating the impact between deubiquitinase and deISGylase activities on viral host e

42 e (PLpro) that has been observed to act as a deubiquitinase and deISGylase to antagonize type I inter

43 e deISGylase activity but retained wild-type deubiquitinase and peptide cleavage activities.

44 vity with no appreciable impact on its other deubiquitinase and peptide cleavage biochemical properti

45 east, where loss of Ataxin-7 inactivates the deubiquitinase and results in increased H2B ubiquitinati

46 nd implements M2 polarization using both its deubiquitinase and RNase activities that cause sequentia

47 ic functions as a ubiquitin binding protein, deubiquitinase and ubiquitin ligase, and its versatile r

48 nents, their modifying E3 ubiquitin ligases, deubiquitinases and corresponding pathophysiological fun

49 a synthetic lethal screen with a library of deubiquitinases and identify USP39, which encodes an ess

50 Our work highlights the plasticity of deubiquitinases and indicates that new conformational st

51 mology also with non-C58-cysteine proteases, deubiquitinases, and deamidases.

52 ve cancers, but the normal functions of this deubiquitinase are not well defined.

53 Deubiquitinases are commonly regarded as constitutively

54 The expression and activity of deubiquitinases are critical for physiology and can go a

55 Deubiquitinases are enzymes that remove ubiquitin moieti

56 Deubiquitinases are important components of the protein

57 Deubiquitinases are proteases with a wide functional div

58 The functions of deubiquitinases are regulated by post-translational modi

59 Here we find that Ubp2 and Ubp3 deubiquitinases are required for the proteasomal degrada

60 -affinity purifications identified the USP13 deubiquitinase as a novel cohesin-interacting protein.

61 977 melanoma cases and 754 controls and used deubiquitinase assays, a pedigree analysis, and a histop

62 The two deubiquitinases associate more with Rsp5 upon heat-stres

63 cognition, TRAF3/6-specific targeting by the deubiquitinase, associated activation of these TRAFs by

64 olyglutamine (polyQ) repeat expansion in the deubiquitinase ataxin-3 causes neurodegeneration in Spin

65 stinct pathways; an important example is the deubiquitinase ataxin3, which collaborates with p97 in e

66 We report that in addition to inhibition of deubiquitinases, b-AP15 inhibits the selenoprotein thior

67 heterozygous loss of histone H2A lysine 119 deubiquitinase BAP1 (BRCA1 Associated Protein-1) associa

68 the important tumour suppressor protein, the deubiquitinase BAP1.

69 Here we reveal how the deubiquitinase Cezanne (also known as OTUD7B) specifical

70 The deubiquitinase cezanne is a direct target of miR-218 and

71 rt that UCH37/UCHL5, a proteasome-associated deubiquitinase, cleaves K48 branched chains.

72 A compensatory upregulation of Usp24, a deubiquitinase closely related to Usp9x, in Usp9x KD cel

73 establish the druggability of the USP1/UAF1 deubiquitinase complex and its potential as a molecular

74 onally interacted with the constituents of a deubiquitinase complex consisting of USP22, ATXN7, and A

75 s BAP1 and ASXL1 interact to form a polycomb deubiquitinase complex that removes monoubiquitin from h

76 SXL1 is the obligate regulatory subunit of a deubiquitinase complex whose catalytic subunit is BAP1.

77 removed by BRISC, an ABRO1/BRCC36-containing deubiquitinase complex.

78 iquitin-specific peptidase 1 (USP1) trimeric deubiquitinase complex.

79 Here, we show that Leon, the Drosophila USP5 deubiquitinase, controls postsynaptic growth.

80 signaling, potentially through inhibition of deubiquitinases, could represent a new therapeutic appro

81 uitin chain assembly complex (LUBAC) and the deubiquitinase CYLD (cylindromatosis).

82 re we report that silencing of the lysine 63 deubiquitinase CYLD increases HIV transcription in an NF

83 Here, we demonstrate that the deubiquitinase Cyld prevents excessive interleukin 18 (I

84 Mechanistically, Spata2 recruits the deubiquitinase CYLD to the centrosome for deubiquitinati

85 We report here that silencing of the deubiquitinase cylindromatosis protein (CYLD), increases

86 Deubiquitinases deconjugate ubiquitin modifications from

87 expression of USP17, a cell cycle-dependent deubiquitinase, decreases ELK-1 ubiquitination and up-re

88 t was inserted into the EVG genome encodes a deubiquitinase/deISGylase and potentially suppresses hos

89 tations in the A20 ovarian tumour (OTU)-type deubiquitinase domain or in the zinc finger-4 (ZnF4) ubi

90 requiring MCPIP1's endoribonuclease but not deubiquitinase domain.

91 ch house histone acetyltransferase (HAT) and deubiquitinase (DUB) activities.

92 b-AP15 and its derivatives block proteasome deubiquitinase (DUB) activity and have been developed an

93 vity blocks oogenesis, while loss of the H2B deubiquitinase (DUB) activity does not.

94 Inhibition of deubiquitinase (DUB) activity is a promising strategy fo

95 We found that a mutant lacking the deubiquitinase (DUB) activity of the VP1-2 protein induc

96 Interestingly, an MHV68 mutant lacking deubiquitinase (DUB) activity, embedded within the large

97 apain-like protease activity, Lpro acts as a deubiquitinase (DUB) and deISGylase.

98 The deubiquitinase (DUB) and tumor suppressor BAP1 catalyzes

99 in which the catalytic domains of different deubiquitinase (DUB) enzymes, with different specificiti

100 frequently mutated in cancer, functions as a deubiquitinase (DUB) for histone H2A.

101 Inhibiting deubiquitinase (DUB) function is a promising strategy fo

102 e [poly(Q)] tract in ATXN7, a subunit of the deubiquitinase (DUB) module (DUBm) in the SAGA complex.

103 rch, Liu and colleagues demonstrate that the deubiquitinase (DUB) OTUB1 is frequently overexpressed i

104 brary of 98 genes, and identified USP20 as a deubiquitinase (DUB) that regulates SNAI2 ubiquitination

105 atalytic domain of herpes simplex virus UL36 deubiquitinase (DUb) to the N-terminal RING domain of rh

106 The deubiquitinase (DUB) Ubp10 is thought to promote heteroc

107 We identified the deubiquitinase (DUB) Ubp7 as a late-arriving endocytic p

108 n the nucleolus, requiring the nucleoplasmic deubiquitinase (DUB) USP1 and the nucleolar DUB USP36.

109 ion or genetic ablation of the mitochondrial deubiquitinase (DUB) USP30 triggers accumulation of Ub-s

110 one of two different viral antagonists, the deubiquitinase (DUB) within nonstructural protein 3 or t

111 biquitin variant (UbV) inhibitors of a human deubiquitinase (DUB), ubiquitin-specific protease 2 (USP

112 9X, a neurodevelopmental-disorder-associated deubiquitinase (DUB).

113 Here, we investigated the role of deubiquitinases (DUB) in regulating ERalpha in breast ca

114 in regulation of the UPS involves targeting deubiquitinases (DUB).

115 Mechanistically, we identify a deubiquitinase, DUB3, as a target of CDK4/6; CDK4/6-medi

116 position on substrate, and susceptibility to deubiquitinases (DUBs) affect processing of different su

117 Deubiquitinases (DUBs) are a new class of drug targets,

118 , and both 20S proteasome peptidases and 19S deubiquitinases (DUBs) are becoming attractive targets o

119 Deubiquitinases (DUBs) are vital for the regulation of u

120 lysines, which can be antagonized by various deubiquitinases (DUBs) including the CYLD tumour suppres

121 hibition of UPS components, particularly key deubiquitinases (DUBs) of the ubiquitin-specific proteas

122 Deubiquitinases (DUBs) remove ubiquitin conjugates from

123 Deubiquitinases (DUBs) reverse ubiquitin signals with eq

124 studies is that ubiquitin ligases (E3s) and deubiquitinases (DUBs), enzymes with opposing activities

125 B2 NZF Ub binding domain (UBD), 10 out of 12 deubiquitinases (DUBs), including USP8, USP15 and USP30,

126 e specificities of two proteasome-associated deubiquitinases (DUBs), Rpn11 and Ubp6, and explored the

127 d is reversed by a class of enzymes known as deubiquitinases (DUBs).

128 us stages, including through its reversal by deubiquitinases (DUBs).

129 ts are well known, as are a variety of viral deubiquitinases (DUBs).

130 Removal of ubiquitin chains is mediated by deubiquitinases (DUBs).

131 We have predicted and validated a set of OTU deubiquitinases encoded by several classes of pathogenic

132 We developed engineered deubiquitinases (enDUBs) that enable selective ubiquitin

133 is tumor-suppressor protein), a K63-specific deubiquitinase enriched in postsynaptic densities, cleav

134 mplex, comprised of the E3 ligase Nrdp1, the deubiquitinase enzyme USP8, and Clec16a, a mediator of b

135 in-specific peptidase 9, X-linked (USP9X), a deubiquitinase enzyme, binds ERG in VCaP prostate cancer

136 With TLR ligation, the deubiquitinase enzyme, STAM-binding protein (STAMBP) imp

137 Deubiquitinase enzymes cleave ubiquitin from substrates

138 an and colleagues identify a sixth family of deubiquitinase enzymes that are highly conserved through

139 Collectively, our results identify CYLD as a deubiquitinase facilitating DNA damage-induced p53 activ

140 conducted a comprehensive evaluation of the deubiquitinase family by gene knockout, identifying seve

141 In this study, we identified a member of the deubiquitinases family, ubiquitin-specific protease 18 (

142 direct antagonism between an E3 ligase and a deubiquitinase, Fbw7 and Usp28, in modulating intestinal

143 For example, BAP1 encodes a widely expressed deubiquitinase for histone H2A, but germline mutations a

144 alogous Legionella effectors, Lpg2154 (DupA; deubiquitinase for PR-ubiquitination) and Lpg2509 (DupB)

145 S holoenzyme, which ultimately activates the deubiquitinase for substrate degradation.

146 reverse PR ubiquitination and are thus named deubiquitinases for PR ubiquitination (DUPs; DupA and Du

147 itin-specific protease 33 (USP33) as cognate deubiquitinases for the GCGR.

148 clear which of the several counteracting H2A deubiquitinases functions along with PRC1 to control H2A

149 The CYLD lysine 63 deubiquitinase gene (CYLD) encodes tumor suppressor prot

150 tion of the cylindromatosis (CYLD) lysine 63 deubiquitinase gene (Cyld), with or without disruption o

151 on by either lysine mutations or fusion of a deubiquitinase hampers NE-derived vesicle formation and

152 The ovarian tumor (OTU) subfamily deubiquitinases have been implicated in the regulation o

153 2 (CK2) phosphorylates RUNX2, recruiting the deubiquitinase herpesvirus-associated ubiquitin-specific

154 USP7 is a deubiquitinase implicated in destabilizing the tumor sup

155 n IL-2 signaling and reduced expression of a deubiquitinase important for FOXP3 stability.

156 ork therefore defines UCH37 as a debranching deubiquitinase important for promoting proteasomal degra

157 ene targeting approach to knockout (KO) this deubiquitinase in chicken DT40 cells.

158 targeting the WEE1 cell cycle kinase or USP1 deubiquitinase in combination with G4 ligand treatment e

159 Here we provide a new role of OTUD5 deubiquitinase in the FACT-dependent process.

160 ancers, we discuss the functions of selected deubiquitinases in acute leukemia and efforts to target

161 udy is the first comprehensive evaluation of deubiquitinases in HIV-1 latency and establishes that th

162 e activities, revealing K63-linkage-specific deubiquitinases in human pathogens, such as Salmonella,

163 Comparable to the deubiquitinases in the canonical ubiquitination pathway,

164 protease 14 (Usp14), a proteasome-associated deubiquitinase, in direct Ag presentation using a ligand

165 inhibition of proteasome-associated cysteine deubiquitinases, in particular ubiquitin specific peptid

166 related to enhanced expression of the USP22 deubiquitinase induced by c-MYC, leading to reduced SIRT

167 in vitro and in vivo, whereas a gradient of deubiquitinase inhibition promotes axon turning in vitro

168 Treatment with the deubiquitinase inhibitor PR-619 increased caspase-8 ubiq

169 we found that the partially selective Usp9x deubiquitinase inhibitor WP1130 induced apoptosis and re

170 suggests opportunities for developing other deubiquitinase inhibitors and may be a strategy more bro

171 However, developing selective deubiquitinase inhibitors has been challenging and no co

172 USP9X is a deubiquitinase involved in multiple signaling and surviv

173 tors is central to Hh signaling, but whether deubiquitinase is involved in this process remains unkno

174 ed; however, it is unknown whether and how a deubiquitinase is involved.

175 OTULIN, a linear linkage-specific deubiquitinase, is essential for the DNA damage-induced

176 tment with a small molecule inhibitor of the deubiquitinase (IU1) increased receptor ubiquitination.

177 tion affecting the catalytic site within the deubiquitinase JAB1/MPN/Mov34 (JAMM)/MPN domain.

178 ice, we identified cylindromatosis (CYLD), a deubiquitinase known to act directly on RIP1 and promote

179 We report that USP28, a deubiquitinase known to be inhibitable by Ni(II) or hypo

180 ction in euploid cells, and deletion of this deubiquitinase leads to further proteasome-mediated prot

181 Thus, the deubiquitinase Leon maintains ubiquitin homeostasis and

182 talytic domain related in fold to Ulp family deubiquitinase-like enzymes and a C-terminal PI3P-bindin

183 Here we report that USP30, a deubiquitinase localized to mitochondria, antagonizes mi

184 sease, indicating that ubiquitin ligases and deubiquitinases maintain the delicate balance between ef

185 he Spt-Ada-Gcn5 acetyltransferase (SAGA) H2B deubiquitinase module competes with Bre1 for binding to

186 chanism in vivo, we found that a recombinant deubiquitinase module is active in the absence of Ataxin

187 Deubiquitinase MYSM1 has been shown to play a critical r

188 ) mouse model, we identified the histone H2A deubiquitinase Mysm1, as a critical regulator in DC diff

189 found that mice deficient in the histone H2A deubiquitinase MYSM1, despite their severe defect in B c

190 the protein stability of USP28, a bona fide deubiquitinase of LSD1.

191 iquitin carboxyl-terminal hydrolase (UCH) L5 deubiquitinases of the 19S proteasome that shows antitum

192 to UBE2N inhibition by this modification and deubiquitinases of this unique ubiquitination.

193 e reversal of this reaction by the USP1:UAF1 deubiquitinase only occurs when DNA is disengaged.

194 rulence factors that function as E3 ligases, deubiquitinases or as enzymes that directly attack ubiqu

195 acterial effector proteins with deSUMOylase, deubiquitinase, or, even, acetyltransferase activities.

196 mulated activation, which is controlled by a deubiquitinase, Otub1.

197 nt and selective probes for two enzymes, the deubiquitinase OTUB2 and the pyrophosphatase NUDT7.

198 Here, we show that an OTU domain deubiquitinase, OTUD4, is a positive regulator of ALKBH2

199 Here, we show that the M1-specific deubiquitinase OTULIN is essential for preventing TNF-as

200 naling, and its function is regulated by the deubiquitinases OTULIN and CYLD, which associate with th

201 ngle E3 ligase complex (LUBAC), one specific deubiquitinase (OTULIN) and a very few linear polyubiqui

202 In contrast to other characterized USP deubiquitinases, our results indicate that USP28 has a c

203 Here, we demonstrate that the deubiquitinase ovarian tumor domain containing ubiquitin

204 for the 19S-resident and degradation-coupled deubiquitinase Poh1 in TRIM21 neutralization, signaling,

205 SXL1, a component of the Polycomb repressive deubiquitinase (PR-DUB) complex, both of which act to re

206 The mammalian Polycomb repressive deubiquitinase (PR-DUB) complexes catalyze removal of mo

207 The tumour suppressor CYLD is a deubiquitinase previously shown to inhibit NF-kappaB, MA

208 tes their trafficking and signaling; whether deubiquitinases regulate myocardial beta(1)-adrenergic r

209 oncanonical mechanism by which an OTU family deubiquitinase regulates its substrates, and provides mu

210 The ovarian tumor (OTU) family of deubiquitinases regulates diverse ubiquitin signals in h

211 Here we report that Usp16, a histone H2A deubiquitinase, regulates H2A deubiquitination and gene

212 Deubiquitinases remove ubiquitin from proteins, and thei

213 Deubiquitinases remove ubiquitin from substrates to prev

214 By contrast, the OTUD7B deubiquitinase removes polyubiquitin chains from GbetaL

215 ctional RNAi screen and identified BAP1 as a deubiquitinase required for efficient assembly of the ho

216 on of H2A could be enforced by inhibition of deubiquitinases, residual HR in BRCA1mt cells might be e

217 xin ubiquitination have been identified, the deubiquitinase responsible for Axin deubiquitination and

218 6S proteasome, where they are removed by the deubiquitinase Rpn11 during ATP-dependent substrate degr

219 l role for the histone acetyltransferase and deubiquitinase SAGA complex in peripheral glia.

220 ination at and eviction from chromatin; as a deubiquitinase, specific to the antagonism of ubiquitin

221 h TIR domain signalosome formation; 2) major deubiquitinases such as A20, CYLD, and DUBA prevent asso

222 d an siRNA screen and identified USP27X as a deubiquitinase that increases Snail1 stability.

223 l hydrolase, UCH-L1, is an abundant neuronal deubiquitinase that is associated with Parkinson's disea

224 entify the mechanism of secretion of TssM, a deubiquitinase that plays an integral role in regulating

225 e (RNAi) libraries, we identified USP47 as a deubiquitinase that prevents beta-catenin ubiquitination

226 identified OTUD3 as an acetylation-dependent deubiquitinase that restricts innate antiviral immune si

227 We recently discovered OTULIN as a deubiquitinase that specifically cleaves Met1-linked pol

228 e encoding A20 to repress expression of this deubiquitinase that suppresses inflammatory NF-kappaB si

229 OTUD4 is a scaffold for USP7 and USP9X, two deubiquitinases that act directly on the AlkB proteins.

230 By down-regulating candidate deubiquitinases that are either linked with GPCR traffic

231 opposed by UBP6/7, two proteasome-associated deubiquitinases that enhance NPR1 longevity.

232 ns of E3 and E4 ligases balanced by opposing deubiquitinases that fine-tune activity of NPR1 without

233 of these sites prevents the binding of USP9x deubiquitinase, thereby promoting the proteasomal degrad

234 velopment of noncatalytic inhibitors of this deubiquitinase to abrogate NF-kB activity.

235 Furthermore, targeting a UbK63-specific deubiquitinase to cilia blocks the exit of GPR161, SSTR3

236 strated that USP21 acts as a bona fide RIG-I deubiquitinase to down-regulate antiviral response indep

237 the Atxn7 amino terminus anchors Non-stop, a deubiquitinase, to the complex.

238 finger (NZF1) domain of the K29/K33-specific deubiquitinase TRABID specifically binds K29/K33-linked

239 ve Npl4 Zinc Finger 1 (NZF1) domain from the deubiquitinase TRABID to enrich for chains from human ce

240 llectively called 'Il23' here) involving the deubiquitinase Trabid.

241 K1 in the context of NASH, we identified the deubiquitinase tumor necrosis factor alpha-induced prote

242 Recent MS studies have shown that OTU deubiquitinase ubiquitin aldehyde-binding 1 (OTUB1), a d

243 Conversely, USP7 (deubiquitinase ubiquitin-specific peptidase 7) opposes t

244 Rather, we identified the deubiquitinase ubiquitin-specific peptidase 9X (USP9X) a

245 ovide, for the first time, evidence that the deubiquitinase ubiquitin-specific protease-14 (Usp14), a

246 perative actions of E3 ubiquitin ligases and deubiquitinases, ubiquitin modifications are implicated

247 cess can be regulated by the Rsp5-associated deubiquitinase, Ubp2.

248 The deubiquitinase Ubp3, which was identified by a genome-wi

249 The Saccharomyces cerevisiae deubiquitinase Ubp7 has been characterized previously as

250 Sumoylation of Smo in turn recruits a deubiquitinase UBPY/USP8 to antagonize Smo ubiquitinatio

251 MD1 revealed that an interacting enzyme, the deubiquitinase UCH37, was also involved in HIV-1 latency

252 family by gene knockout, identifying several deubiquitinases, UCH37, USP14, OTULIN, and USP5 as possi

253 hanistically, in response to DNA damage, the deubiquitinase UCHL3 is phosphorylated and activated by

254 The deubiquitinase USP10 specifically removes ubiquitination

255 Huwe1 activity on TBP is antagonized by the deubiquitinase USP10, which protects TBP from degradatio

256 ugh Notch/Hey1-induced repression of the PML deubiquitinase USP11 and suggests an important role for

257 ough the transcriptional upregulation of the deubiquitinase USP11 by the PI3K/FOXO pathway, and furth

258 ical analyses of an evolutionarily conserved deubiquitinase, USP12, which is activated by two beta-pr

259 Here we report that a deubiquitinase, USP13, regulates DDR by targeting RAP80.

260 We identified the deubiquitinase USP14 as a novel autophagy substrate and

261 OK1 by mass spectrometry, and identified the deubiquitinase USP16 among the captured factors.

262 of ML364, a small molecule inhibitor of the deubiquitinase USP2 and its use to interrogate the biolo

263 E3 ligase Nedd4 and deubiquitination by the deubiquitinases USP20 and USP33 have been shown to regul

264 Here we report that the E3 deubiquitinase USP21 prevents the depletion of FOXP3 at

265 Functional comparison of three deubiquitinases (USP21, A20, and CYLD) demonstrated that

266 Emerging evidence indicates the deubiquitinase USP22 regulates transcriptional activatio

267 The deubiquitinase USP28 stabilizes oncogenic factors, inclu

268 encoding the p53-binding protein 53BP1, the deubiquitinase USP28, and the ubiquitin ligase TRIM37.

269 This activity is antagonized by the deubiquitinase Usp28, which is highly expressed in murin

270 In this study, we identify that the deubiquitinase USP36 interferes with degradation of Prim

271 the subcellular localization of the protein deubiquitinase USP4 and, in turn, its function in the ce

272 Here we report that a deubiquitinase, USP49, is a new regulator of the AKT pat

273 We identified the deubiquitinase USP7 as a MYCN-associated synthetic vulne

274 The deubiquitinase USP7 is a regulator of key cellular pathw

275 ion elongation factor Elongin BC and the H2B deubiquitinase USP7 to modulate transcriptional processe

276 BP1 by accelerating its interaction with the deubiquitinase USP7.

277 ort that PHF8 physically associates with the deubiquitinase USP7.

278 f CHMP5 by inducing its interaction with the deubiquitinase USP8.

279 content and pathological localization of the deubiquitinase Usp8.

280 Drosophila model, unlike knockdown of other deubiquitinases, Usp8 protected from alpha-synuclein-ind

281 ere, we define a cell intrinsic role for the deubiquitinase Usp9X during proximal TCR signaling.

282 anner, we found that loss of function in the deubiquitinase USP9X prevented proliferation arrest by t

283 a, the E3 ligases MULE and betaTrCP, and the deubiquitinase USP9x regulate cytokine-mediated MCL-1 pr

284 ctions with a newly identified Gal9 partner, deubiquitinase USP9X, diminishes upon lysosomal injury.

285 in early mitosis and deubiquitinated by the deubiquitinase VCIP135 in late mitosis.

286 port that, in response to DPC induction, the deubiquitinase VCPIP1/VCIP135 is phosphorylated and acti

287 nsisting of the HECT E3 ligase UBE3C and the deubiquitinase vOTU.

288 nt regulation of Non-stop, substrates of the deubiquitinase were sought.

289 We identify Dub3 as a bona fide Snail1 deubiquitinase, which interacts with and stabilizes Snai

290 unfoldase/segregase and the Ataxin 3 (ATX3) deubiquitinase, which together form a physical and funct

291 release requires cooperation of Cdc48 with a deubiquitinase, which trims polyubiquitin to an oligoubi

292 s identified Usp16 as one of the histone H2A deubiquitinases, which coordinates with the H2A ubiquiti

293 nistically, we identified ATXN3 as a Ub-Rheb deubiquitinase whose lysosomal localization is blocked b

294 USP7 is a protein deubiquitinase with an essential role in development.

295 OTULIN (OTU Deubiquitinase With Linear Linkage Specificity) specific

296 on mutations in OTULIN (FAM105B), encoding a deubiquitinase with linear linkage specificity.

297 domain revealed high similarity to mammalian deubiquitinases with a unique alpha-helix close to the s

298 2c inhibited representative deubiquitinases with micromolar IC50, and its proapoptot

299 nts exhibit increased affinity for the USP14 deubiquitinase, with concomitantly reduced affinity for

300 e processing and is accomplished by Rpn11, a deubiquitinase within the 'lid' sub-complex.

301 enzymatic activities with two mitochondrial deubiquitinases, yeast ScUBP16 and human HsUSP30, which