ライフサイエンスコーパス: deubiquitinate

1 extracted back to the cytosol and, finally, deubiquitinated.

2 AD, reflecting the different consequences of deubiquitinating a substrate prior to proteasomal degrad

3 y should prove useful in understanding PLpro deubiquitinating activities in coronavirus infections.

4 ndent mutant coronaviruses, one with reduced deubiquitinating activity (DUBmut) and the other contain

5 gene-targeted mice, abrogating either A20's deubiquitinating activity (Tnfaip3(OTU) mice) or A20's Z

6 Characterization of EBV BPLF1's deubiquitinating activity and identification of its targ

7 We find that the Sgf73 mutations abrogate deubiquitinating activity by impacting the Ubp8 ubiquiti

8 omain and has been proposed to contribute to deubiquitinating activity by maintaining the catalytic d

9 easomes lacking Usp14 also exhibited greater deubiquitinating activity by Rpn11 and greater basal ATP

10 l inclusion serves as an enriched site for a deubiquitinating activity exerting a function in selecti

11 adation, Usp15 is not degraded but loses its deubiquitinating activity for IkappaBalpha deubiquitinat

12 is interaction occurred independently of the deubiquitinating activity of CYLD.

13 d activity of PPARgamma are modulated by the deubiquitinating activity of HAUSP, which may be a targe

14 mization of small molecules that inhibit the deubiquitinating activity of USP1/UAF1.

15 minal domain, its truncation does not impair deubiquitinating activity on diubiquitin or polyubiquiti

16 es how EBV's BPLF1 protein and its conserved deubiquitinating activity regulate the cellular DNA repa

17 V) encodes BPLF1, a lytic cycle protein with deubiquitinating activity that is contained in its N-ter

18 The BPLF1 protein expresses deubiquitinating activity that is strictly conserved acr

19 proteins and remove polyubiquitin chains via deubiquitinating activity, are two important virulence f

20 effect of Cif was mediated by reducing USP10 deubiquitinating activity, resulting in increased polyub

21 nal domain of USP28 negatively regulates its deubiquitinating activity, revealing a role for the N-te

22 different Sgf73 point mutations that disrupt deubiquitinating activity.

23 esidues 785 and 787, which negatively affect deubiquitinating activity.

24 domain, resulting in auto-inhibition of its deubiquitinating activity.

25 itination of PCNA, is also affected by BPLF1 deubiquitinating activity.

26 We conclude that the GCGRs are rapidly deubiquitinated after agonist-activation to facilitate R

27 ates the GCGR, whereas both STAMBP and USP33 deubiquitinate agonist-activated GCGRs at early endosome

28 -20, WDR-48, and USP-46 function together to deubiquitinate and stabilize GLR-1 in neurons.

29 complex with USP-46 and stimulate the DUB to deubiquitinate and stabilize GLR-1 in vivo.

30 -mediated activation of DUB3 is essential to deubiquitinate and stabilize SNAIL1, a key factor promot

31 rectly to the supervillin N terminus and can deubiquitinate and stabilize supervillin.

32 reveal USP48 as the first identified DUB to deubiquitinate and stabilize TRAF2 in epithelial cells.

33 ellular lysines altered to arginines remains deubiquitinated and shows augmented trafficking to Rab4a

34 temness and metastasis-promoting factor that deubiquitinates and activates YAP/TAZ.

35 that ubiquitin-specific protease 20 (USP20) deubiquitinates and attenuates lysosomal trafficking of

36 USP21 interacts with, deubiquitinates and stabilizes BRCA2 to promote efficien

37 USP20 in turn deubiquitinates and stabilizes Claspin and enhances the

38 Mechanistically, USP49 deubiquitinates and stabilizes FKBP51, which in turn enh

39 report that in response to DNA damage, COPS5 deubiquitinates and stabilizes PEA15 in an ATM kinase-de

40 USP11 deubiquitinates and stabilizes PML, thereby counteractin

41 Mechanistically, USP21 deubiquitinates and stabilizes the TCF/LEF transcription

42 USP13 specifically deubiquitinates and thus upregulates ATP citrate lyase a

43 protease and coronavirus PLPs, which act as deubiquitinating and deISGylating (interferon [IFN]-stim

44 as an interferon antagonist, which involves deubiquitinating and deISGylating cellular proteins.

45 PLP2 catalytic domain was found to have both deubiquitinating and deISGylating isopeptidase activitie

46 controls CTA1 retro-translocation, likely by deubiquitinating and inactivating ubiquitinated ERAD com

47 Mop aids in the maintenance of Ubpy, which deubiquitinates (and thus stabilizes) Hrs.

48 mpairs the 26S proteasome's ability to bind, deubiquitinate, and degrade ubiquitinated proteins.

49 und that TNFAIP3 directly interacts with and deubiquitinates ASK1 in hepatocytes.

50 Subsequently, USP15 deubiquitinates BARD1 BRCT domain, and promotes BARD1-HP

51 ubiquitin ligase HACE1 in early mitosis and deubiquitinated by the deubiquitinase VCIP135 in late mi

52 H2B is deubiquitinated by the Spt-Ada-Gcn5 acetyltransferase (S

53 In yeast, H2B-Ub is deubiquitinated by Ubp8, a subunit of SAGA, and Ubp10.

54 ed ubiquitin chains by the PRP19 complex and deubiquitinated by USP15 and its substrate targeting fac

55 within TPP1 that are oligo-ubiquitinated and deubiquitinated by USP7.

56 interacted with Clb5 independent of Cdh1 and deubiquitinated Clb5 in a reconstituted system.

57 USP33 potently and specifically deubiquitinates CP110, but not other cyclin-F substrates

58 ntify that USP52 directly interacts with and deubiquitinates CtIP, thereby promoting DNA end resectio

59 iquitin-specific proteases, UBP12 and UBP13, deubiquitinate DA1, DAR1 and DAR2, hence reducing their

60 e N terminus were found to possess protease, deubiquitinating, deISGylating, and interferon antagonis

61 ), a core subunit of an Lnk-associated Lys63 deubiquitinating (DUB) complex, attenuates HSC expansion

62 ves the viral replicase polyprotein and as a deubiquitinating (DUB) enzyme which removes ubiquitin (U

63 1 activating, E2 conjugating, E3 ligase, and deubiquitinating (DUB) enzymes offers an ideal platform

64 tains a four-protein subcomplex known as the deubiquitinating (DUB) module.

65 Both DUBs are capable of deubiquitinating Ede1 in vitro.

66 UBPY by STAM2 displaces ESCRT-0 from HD-PTP, deubiquitinates EGFR, and releases ESCRT-0 from cargo in

67 s detected by co-immunoprecipitation, and it deubiquitinated ENaC.

68 Here, we show that the chlamydial deubiquitinating enzyme (Cdu) 1 localizes in the inclusi

69 MERS-CoV PL(pro) was recently shown to be a deubiquitinating enzyme (DUB) and to possess deISGylatin

70 is(thiocyanate) (PR-619) is a broad-spectrum deubiquitinating enzyme (DUB) inhibitor that has been em

71 rocess, the aim of this study is to identify deubiquitinating enzyme (DUB) regulating the post-endoso

72 BRCC36 is a Zn(2+)-dependent deubiquitinating enzyme (DUB) that hydrolyzes lysine-63-

73 Ubiquitin specific peptidase 7 (USP7) is a deubiquitinating enzyme (DUB) that removes ubiquitin tag

74 and DEUBAD domain, which binds and activates deubiquitinating enzyme (DUB) UCHL5/Uch37.

75 apid dephosphorylation and activation of the deubiquitinating enzyme (DUB) USP8.

76 Here, we have identified the deubiquitinating enzyme (DUB), ubiquitin-specific protea

77 ubiquitination is well studied; however, the deubiquitinating enzyme (DUB), which regulates TRAF2 sta

78 dislocation of MHCI heavy chains did require deubiquitinating enzyme activity and rapid proteasome-me

79 trate that USP53 is a catalytically inactive deubiquitinating enzyme and a novel component of tight j

80 Itch interacts with the deubiquitinating enzyme and is required for deubiquitina

81 Ataxin-3 is a deubiquitinating enzyme and the affected protein in the

82 ubiquitination processes involving the AMSH1 deubiquitinating enzyme are thus involved in both infect

83 Collectively these results implicate a deubiquitinating enzyme as a regulator of the UPR.

84 The deubiquitinating enzyme associated molecule with the SH3

85 One such protein is the deubiquitinating enzyme ataxin 3, which is widely expres

86 The deubiquitinating enzyme BAP1 is mutated in a hereditary

87 This deubiquitinating enzyme binds BoNT/A light chain directl

88 Downregulation of the deubiquitinating enzyme complex Upb3-Bre5 increased the

89 w here that a LNK-associated lysine-63 (K63)-deubiquitinating enzyme complex, Brcc36 isopeptidase com

90 Incubation with a deubiquitinating enzyme converted the p110:p107 PEPC het

91 n-induced and NF-kappaB-driven expression of deubiquitinating enzyme CSN5 leads to PD-L1 stabilizatio

92 last precursors, Itch bound to TRAF6 and the deubiquitinating enzyme cylindromatosis.

93 ry proteins such as Bro1, which recruits the deubiquitinating enzyme Doa4 to remove ubiquitin from ca

94 mbrane and faces the cytosol with the active deubiquitinating enzyme domain.

95 used by a mutation in Usp53, a member of the deubiquitinating enzyme family.

96 entify UCH37 as the first, to our knowledge, deubiquitinating enzyme for E2F1.

97 indicate that UCHL1 promotes metastases as a deubiquitinating enzyme for HIF-1alpha, which justifies

98 quitin specific protease 7 (USP7) is a known deubiquitinating enzyme for tumor suppressor p53 and its

99 Ubiquitin-specific protease 7 (USP7) is a deubiquitinating enzyme found in all eukaryotes that cat

100 g that hRpn13 interaction may stabilize this deubiquitinating enzyme in human cells.

101 ly binding the promoter region of Tnfaip3, a deubiquitinating enzyme in TLR signaling.

102 Here, we show that the USP7 deubiquitinating enzyme is an integral component of the

103 The USP19 deubiquitinating enzyme modulates the expression of myog

104 We report here that USP8/UBPY, a deubiquitinating enzyme not previously implicated in mit

105 th ubiquitin-specific protease 10 (USP10), a deubiquitinating enzyme of p53.

106 nase ubiquitin aldehyde-binding 1 (OTUB1), a deubiquitinating enzyme of the OTU family, is enriched t

107 Finally, ubiquitin chains are trimmed by the deubiquitinating enzyme Otu1p, which is recruited and ac

108 -linked ubiquitin chains via the proteasomal deubiquitinating enzyme Poh1.

109 itin-specific protease (USP) 6 is a hominoid deubiquitinating enzyme previously implicated in intelle

110 65 nm UV treatment and enables intracellular deubiquitinating enzyme profiling.

111 e reveal that Cezanne (also known as Otud7B) deubiquitinating enzyme promotes the recruitment of Rap8

112 unknown interplay between an E3 ligase and a deubiquitinating enzyme regulating TBP levels during cel

113 97/p47 complex-interacting protein, p135), a deubiquitinating enzyme required for p97/p47-mediated po

114 ate binding, preventative modifications, and deubiquitinating enzyme reversal of ubiquitination.

115 Furthermore, we identify USP36 as the deubiquitinating enzyme that deubiquitinates EZH2 at K22

116 biquitin C-terminal hydrolase L1 (UCH-L1), a deubiquitinating enzyme that functions to regulate cellu

117 USP28 (ubiquitin-specific protease 28) is a deubiquitinating enzyme that has been implicated in the

118 quitin C-terminal hydrolase L1 (UCH-L1) is a deubiquitinating enzyme that is highly expressed in neur

119 an ubiquitin-specific protease 7 (USP7) is a deubiquitinating enzyme that prevents protein degradatio

120 USP14 is a proteasome-bound deubiquitinating enzyme that recycles ubiquitin and regu

121 dentification of OTUB1 as a c-IAP-associated deubiquitinating enzyme that regulates c-IAP1 stability.

122 It encodes a deubiquitinating enzyme that removes Lys63- or linear-li

123 itination of Hrd1 is counteracted by Ubp1, a deubiquitinating enzyme that requires its N-terminal tra

124 remodeling to generate a Poh1-dependent K63-deubiquitinating enzyme to facilitate protein aggregate

125 vities of the ubiquitination machinery and a deubiquitinating enzyme to maintain and modulate the dyn

126 The deubiquitinating enzyme ubiquitin C-terminal hydrolase-L

127 sing a proteomic approach, we identified the deubiquitinating enzyme ubiquitin-specific protease 11 (

128 ionally, an opioid-mediated induction of the deubiquitinating enzyme ubiquitin-specific protease 15 w

129 Employing this method, we identified the deubiquitinating enzyme ubiquitin-specific protease 22 (

130 romyces cerevisiae, Cdh1 associates with the deubiquitinating enzyme Ubp15, but the significance of t

131 a core particle (CP) subunit depends on the deubiquitinating enzyme Ubp3, although a regulatory part

132 tin chain disassembly, by binding the UBL of deubiquitinating enzyme Ubp6.

133 onstrate a hitherto unrecognized role of the deubiquitinating enzyme UCH-L1 in DC Ag processing.

134 m1 and S5a, the ATPase subunit Rpt5, and the deubiquitinating enzyme Uch37 are ubiquitinated in situ

135 5),report crystal structures that define how deubiquitinating enzyme UCH37 is switched on or off by p

136 inase adaptor (DEUBAD) domain that binds the deubiquitinating enzyme Uch37.

137 in receptor hRpn13/Adrm1 binds and activates deubiquitinating enzyme Uch37/UCHL5 and is targeted by b

138 thermore, BDNF increased the activity of the deubiquitinating enzyme UchL1 in synaptoneurosomes and u

139 The deubiquitinating enzyme USP1 (ubiquitin-specific proteas

140 ns on histones, is actively destroyed by the deubiquitinating enzyme USP1.

141 ch resulted in a decreased expression of the deubiquitinating enzyme USP14 and several presynaptic pr

142 The proteasome-associated deubiquitinating enzyme Usp14/Ubp6 inhibits protein degr

143 0-20% in our preparations) also contains the deubiquitinating enzyme Usp14/Ubp6, which regulates prot

144 Hrd1 interacts directly with the deubiquitinating enzyme Usp15.

145 removal of ubiquitin from this lysine by the deubiquitinating enzyme USP19.

146 In this study, we characterize a role of the deubiquitinating enzyme USP30 in peroxisome maintenance.

147 Because the deubiquitinating enzyme USP33 is involved in several imp

148 ome (activated by the Cdh1 adapter), and the deubiquitinating enzyme USP35.

149 The deubiquitinating enzyme USP48 stabilizes TRAF2 and reduc

150 x and leads to interaction between FoxM1 and deubiquitinating enzyme USP5, thereby deubiquitination a

151 w role for vIRF1 through deregulation of the deubiquitinating enzyme USP7 to inhibit p53-mediated ant

152 oordinated action of UBE4B, ESCRT-0, and the deubiquitinating enzyme USP8 enable the endosomal sortin

153 uitin ligase MARCH4, the ATPase p97/VCP, the deubiquitinating enzyme USP8, the cullin-RING ligase (CR

154 ains on the substrate in the presence of the deubiquitinating enzyme USP8.

155 Here we show that in vivo knockdown of the deubiquitinating enzyme USP9X attenuates T-cell prolifer

156 dge, we have identified the first centriolar deubiquitinating enzyme whose expression regulates centr

157 Here, we identified the deubiquitinating enzyme YOD1 (OTUD2) as a novel interact

158 of cofactors including UBXD1, PLAA, and the deubiquitinating enzyme YOD1, which we term ELDR compone

159 perativity between an ubiquitin ligase and a deubiquitinating enzyme, and establish a role for USP7 i

160 ical analysis showed that AMSH1 is an active deubiquitinating enzyme, and that AMSH1 specifically cle

161 ncluding the Stk11 protein kinase, the Usp9x deubiquitinating enzyme, and their substrate kinase MARK

162 Here, we report USP15, a deubiquitinating enzyme, as a regulator of protein-prote

163 We further identify the deubiquitinating enzyme, BRCC3, as a critical regulator

164 removal of ubiquitin from H2AK15ub by USP51 deubiquitinating enzyme, leading to a pronounced accumul

165 c peptidase 8 (USP8), an endosome-associated deubiquitinating enzyme, regulates the ubiquitination, t

166 Here, we characterize a yeast deubiquitinating enzyme, Ubp10, that possesses IDRs flan

167 s/PKA signaling is negatively regulated by a deubiquitinating enzyme, Ubp3.

168 Here we report that the deubiquitinating enzyme, USP15, specifically deubiquitin

169 r direct effectors of ubH2B, we identified a deubiquitinating enzyme, Usp15, through affinity purific

170 interactions between a 100 kDa, multi-domain deubiquitinating enzyme, USP5 and a diubiquitin substrat

171 t that Ets-1 destruction is regulated by the deubiquitinating enzyme, Usp9x, and has major impact on

172 omal degradation by the dominant effect of a deubiquitinating enzyme, VCIP135/VCPIP1.

173 in-specific protease 7 (USP7) is a prominent deubiquitinating enzyme, with an extensive network of in

174 These data show how a deubiquitinating enzyme-interacting protein dictates the

175 ssemble substrates, shuttling factors, and a deubiquitinating enzyme.

176 ations in USP9X, encoding a highly conserved deubiquitinating enzyme.

177 by the enzymatic activity of the EBV-encoded deubiquitinating enzyme.

178 rolase L1 (UCHL1) is a unique brain-specific deubiquitinating enzyme.

179 he Hippo pathway via ubiquitination, yet few deubiquitinating enzymes (DUB) have been implicated.

180 port that BITC and PEITC effectively inhibit deubiquitinating enzymes (DUB), including the enzymes US

181 reagents by tailored targeting of all human deubiquitinating enzymes (DUBs) and identify their essen

182 Deubiquitinating enzymes (DUBs) are a growing target cla

183 Ubiquitinating as well as deubiquitinating enzymes (DUBs) can regulate these proce

184 Deubiquitinating enzymes (DUBs) have emerged as key play

185 the dynamic removal of this modification by deubiquitinating enzymes (DUBs) impacts genome maintenan

186 are treated with a panel of linkage-specific deubiquitinating enzymes (DUBs) in parallel reactions, f

187 To search for the deubiquitinating enzymes (DUBs) involved in the antivira

188 The functional diversity of deubiquitinating enzymes (DUBs) is not well understood.

189 Deubiquitinating enzymes (DUBs) recognize and cleave lin

190 Deubiquitinating enzymes (DUBs) regulate various cellula

191 Deubiquitinating enzymes (DUBs) remove ubiquitin (Ub) fr

192 However, the mechanisms that regulate the deubiquitinating enzymes (DUBs) responsible for the remo

193 The discovery of viruses encoding deubiquitinating enzymes (DUBs) suggests they remove ubi

194 The deubiquitinating enzymes (DUBs) that function in the ner

195 at the stability of ARTs is regulated by the deubiquitinating enzymes (DUBs) Ubp2 and Ubp15.

196 formed the expected covalent complexes with deubiquitinating enzymes (DUBs) USP2 and USP7, highlight

197 The evolutionarily related deubiquitinating enzymes (DUBs) USP25 and USP28 comprise

198 romise in profiling the activity of cellular deubiquitinating enzymes (DUBs) with the much needed tem

199 the coronaviral enzyme over homologous human deubiquitinating enzymes (DUBs), and no significant cyto

200 Deubiquitinating enzymes (DUBs), which reverse the proce

201 ubiquitin chain and binds to 26 S-associated deubiquitinating enzymes (DUBs): in yeast to Ubp6, which

202 , we performed a siRNA screening to identify deubiquitinating enzymes and found that USP36 acts as an

203 peptides protected K48-linked Ub chains from deubiquitinating enzymes and prevented proteasomal degra

204 and ENY2 orchestrate activities of multiple deubiquitinating enzymes and that imbalances in these ac

205 Deubiquitinating enzymes are critical to this process, a

206 Hence, deubiquitinating enzymes could offer novel therapeutic t

207 lf, the ubiquitin conjugation machinery, and deubiquitinating enzymes enable activity and regulation

208 TRAF6 activity can be impeded by deubiquitinating enzymes like ubiquitin-specific proteas

209 Finally, pharmacologic inhibition of deubiquitinating enzymes markedly enhances sterol-depend

210 Deubiquitinating enzymes of the ovarian tumour (OTU) fam

211 Here, through the use of linkage-specific deubiquitinating enzymes tethered to TRIM5alpha, we deli

212 ow that Cezanne and Cezanne2, two paralogous deubiquitinating enzymes that are recruited to sites of

213 target them for proteosomal degradation and deubiquitinating enzymes that promote their stabilizatio

214 We performed an siRNA screen to identify deubiquitinating enzymes that regulate AR; in that scree

215 Less is known, however, about the deubiquitinating enzymes that regulate T cell proliferat

216 C3ylation"), with ATG4 proteases acting like deubiquitinating enzymes to counteract this modification

217 roteasome function through inhibition of the deubiquitinating enzymes USP14 and UCHL5.

218 e disassembly of these heterodimers by major deubiquitinating enzymes was examined and it was discove

219 me can be antagonized by proteasome-residing deubiquitinating enzymes, by the binding of polyubiquiti

220 Deubiquitinating enzymes, or DUBs, comprise a family of

221 The diverse roles of deubiquitinating enzymes, or DUBs, in determining the fa

222 chanisms, including ubiquitin E3 ligases and deubiquitinating enzymes, provide great opportunities fo

223 the most widely studied among the nearly 100 deubiquitinating enzymes, supports cancer by positively

224 However, the deubiquitinating enzymes, which regulate MSH2 remain unk

225 ases (USPs) constitute the largest family of deubiquitinating enzymes, whose catalytic competency is

226 Three deubiquitinating enzymes-Rpn11, Usp14, and Uch37-are ass

227 jugation is a reversible process mediated by deubiquitinating enzymes.

228 asome and one of three proteasome-associated deubiquitinating enzymes.

229 These include E3 ubiquitin ligases and deubiquitinating enzymes.

230 ubiquitin ligases (E3s) and removed through deubiquitinating enzymes.

231 alpha-helical hairpin that is unusual among deubiquitinating enzymes.

232 eins, IKK, NF-kappaB, ubiquitin ligases, and deubiquitinating enzymes.

233 n tumor domain (OTU)-containing subfamily of deubiquitinating enzymes.

234 tate cancer cells expressing TMPRSS2-ERG and deubiquitinates ERG in vitro.

235 fy USP36 as the deubiquitinating enzyme that deubiquitinates EZH2 at K222.

236 Mechanistically, USP36 is deubiquitinated following DNA replication stress, which

237 We find that the DUB module deubiquitinates H2B both in the context of the nucleosom

238 Consistent with a role for FACT in deubiquitinating H2B in vivo, a FACT mutant strain shows

239 yeast which lacks the enzyme responsible for deubiquitinating H2B-K123, compared to wild-type yeast.

240 omplex, a USP22-ATXN7L3B-ENY2 complex cannot deubiquitinate H2Bub1 efficiently in vitro Moreover, ATX

241 ptidase 4 (USP4) interacts directly with and deubiquitinates HDAC2, leading to the stabilization of H

242 omatin-binding transcriptional cofactor that deubiquitinates histone H2A.

243 RuvB-like1 (RVB1) and SUG1 and specifically deubiquitinates histone H2B in vitro and in vivo.

244 ctions in transcription activation including deubiquitinating histone H2B, which is mediated by a sub

245 USP11 can deubiquitinate hybrid SUMO-ubiquitin chains to counterac

246 ving its ubiquitin chain, thus promoting the deubiquitinated I-kappaB degradation within the proteaso

247 ting overactivation of WASH through directly deubiquitinating it.

248 Furthermore, USP47 deubiquitinates itself, whereas beta-TrCP promotes USP47

249 We found that USP6 directly deubiquitinated Jak1, leading to its stabilization and a

250 USP36 deubiquitinates K29-linked polyubiquitination of PrimPol

251 nd, both in cells and after purification, it deubiquitinated K63-linked chains on alpha-synuclein.

252 deubiquitinating enzyme, USP15, specifically deubiquitinates Keap1, which suppresses the Nrf2 pathway

253 er show that USP8 acts downstream of IDOL to deubiquitinate LDLR and that USP8 is required for LDLR e

254 the trafficking and degradation of BACE1 by deubiquitinating lysine 501.

255 ific protease 22 (USP22), a component of the deubiquitinating module (DUBm) of the SAGA transcription

256 which is mediated by a subcomplex called the deubiquitinating module (DUBm).

257 A20 possesses a deubiquitinating motif and a zinc finger, ZF4, that bind

258 A20's C103 deubiquitinating motif restricted both K48- and K63-link

259 lex required the catalytic cysteine of A20's deubiquitinating motif.

260 USP10 deubiquitinates MSH2 in vitro and in vivo Moreover, the

261 STAMBP deubiquitinates NALP7 and STAMBP knockdown abrogates LPS

262 (IL-18) production in the colonic mucosa by deubiquitinating NLRP6.

263 In conclusion, UBP12/UBP13 deubiquitinate ORE1 to stabilize this transcription fact

264 interacting protein USP28 that can directly deubiquitinate p53 in vitro and ectopically stabilize p5

265 Ubiquitin-specific protease 7 (USP7) deubiquitinates p53 and Hdm2 and regulates their stabili

266 Mechanistically, CYLD interacts with and deubiquitinates p53 facilitating its stabilization in re

267 but not its catalytically-defective mutants deubiquitinates Poleta and increases its cellular steady

268 We found that UBP12/UBP13 can deubiquitinate polyubiquitinated ORE1 in vitro and incre

269 very few clinically appropriate effectors of deubiquitinating (protease) or ubiquitinating (ligase) e

270 asome regulatory subunit 19 S that regulates deubiquitinated proteins entering inside the proteasome

271 this ternary complex serves as a platform to deubiquitinate PRP31 and PRP3.

272 UCHL3, in turn, deubiquitinates RAD51 and promotes the binding between R

273 USP13, in turn, deubiquitinates RAP80 and promotes RAP80 recruitment and

274 responses through its ability to bind to and deubiquitinate RIG-I.

275 ive regulation of antiviral response through deubiquitinating RIG-I.

276 VCPIP1, in turn, deubiquitinates SPRTN and promotes its chromatin relocal

277 air, we find that it is predominantly in the deubiquitinated state in the nucleolus, requiring the nu

278 p107, and subsequent phosphorylation of the deubiquitinated subunits.

279 ated poorly with the beta(1)AR and failed to deubiquitinate the beta(1)AR.

280 that Usp12, in complex with Uaf-1 and WDR20, deubiquitinates the AR to enhance receptor stability and

281 We found previously that the DUB USP-46 deubiquitinates the Caenorhabditis elegans glutamate rec

282 ynthesis (TLS), is disrupted by BPLF1, which deubiquitinates the DNA processivity factor, PCNA, and i

283 USP7 deubiquitinates the E3 ubiquitin ligase NEDD4L, which me

284 Our data suggest that USP33 constitutively deubiquitinates the GCGR, whereas both STAMBP and USP33

285 domains 1 (MYSM1) is a metalloprotease that deubiquitinates the K119-monoubiquitinated form of histo

286 er investigation reveals that OTUD1 directly deubiquitinates the TGF-beta pathway inhibitor SMAD7 and

287 domain of the SPATA2 complex preferentially deubiquitinating the M1 ubiquitin chain in vitro.

288 Here we show that USP7 interacts with and deubiquitinates Tip60 both in vitro and in vivo.

289 anonical NF-kappaB stimuli, OTUD7B binds and deubiquitinates TRAF3, thereby inhibiting TRAF3 proteoly

290 Doa4, which is the ubiquitin hydrolase that deubiquitinates transmembrane proteins sorted as cargoes

291 ranscription and suppresses tumorigenesis by deubiquitinating TRIM25, providing a potential target fo

292 ion on TrkA was indirect because it does not deubiquitinate TrkA.

293 MvcA functions to deubiquitinate UBE2N-Ub using the same catalytic triad r

294 UCH37 does not deubiquitinate UbK48 chains or affect E2F1 protein stabi

295 We find that Rad18 is deubiquitinated when cells are treated with methyl metha

296 Upon netrin treatment, VASP is deubiquitinated, which promotes VASP tip localization an

297 gulates nucleotide excision repair (NER) via deubiquitinating xeroderma pigmentosum complementation g

298 Importantly, USP7 efficiently deubiquitinates XPC-ubiquitin conjugates in deubiquitina

299 important role of USP7 in regulating NER via deubiquitinating XPC and by preventing its VCP/p97-regul

300 Usp9X becomes competent to deubiquitinate ZAP70 through TCR-dependent phosphorylati