ライフサイエンスコーパス: deubiquitination

1 gatively regulate autophagy by promoting K63 deubiquitination.

2 ated-ubiquitin (Ub) is protected from active deubiquitination.

3 ve when they are "unlocked" by Ubp2-mediated deubiquitination.

4 functional role for ASXL3 in PR-DUB mediated deubiquitination.

5 s are required for ubiquitin binding and H2A deubiquitination.

6 ly regulated by cycles of ubiquitination and deubiquitination.

7 interference leads to the suppression of p53 deubiquitination.

8 re and function independently of its role in deubiquitination.

9 SP7 and p53 and attenuates USP7-mediated p53 deubiquitination.

10 assay revealed that USP14 targeted Ku70 for deubiquitination.

11 yed TNF receptor-associated factor 6 (TRAF6) deubiquitination.

12 UBPY also bind STAM2 SH3 to facilitate EGFR deubiquitination.

13 e formation suggest allosteric regulation of deubiquitination.

14 the diubiquitin substrate in USP2-catalyzed deubiquitination.

15 scriptionally prime NLRP3 by stimulating its deubiquitination.

16 istone acetylation and Ubp8-mediated histone deubiquitination.

17 the enzymes involved in MITF ubiquitination/deubiquitination.

18 tation activity mediates degradation-coupled deubiquitination.

19 osis of several receptors by virtue of their deubiquitination.

20 cifically directs USP1-UAF1 complex for PCNA deubiquitination.

21 ly endosomes eliminated agonist-induced GCGR deubiquitination.

22 al strategy used to achieve linkage-specific deubiquitination.

23 stem or be reactivated by USP-33/20-mediated deubiquitination.

24 ereas overexpression of USP14 promotes CXCR4 deubiquitination.

25 known about counter mechanisms for receptor deubiquitination.

26 7 domains is required for efficient Pol iota deubiquitination.

27 sociated directly with STING, leading to its deubiquitination.

28 ves a cycle of ubiquitination and subsequent deubiquitination.

29 ecific protease 9X-mediated (USP9X-mediated) deubiquitination.

30 emical coupling of substrate degradation and deubiquitination.

31 perative stable ternary complex required for deubiquitination.

32 ite of ILV budding while the cargoes undergo deubiquitination.

33 ng proteasome activity even when inactive in deubiquitination.

34 transcriptional regulator mediating histone deubiquitination.

35 m to delay ILV budding while cargoes undergo deubiquitination.

36 he proteasome was reduced by USP14-dependent deubiquitination.

37 or to lysosomal degradation and promotes its deubiquitination.

38 ex mechanism of step-wise ubiquitination and deubiquitination activities that allows contemporaneous

39 Whether a competing JAK2 deubiquitination activity exists is unknown.

40 tion coactivator that contains a histone H2B deubiquitination activity mediated by its Ubp8 subunit.

41 ition and the H2A(Y57F) mutation enhance H2B deubiquitination activity of the Spt-Ada-Gcn5 acetyltran

42 ubiquitination, while Usa1 attenuates Ubp1's deubiquitination activity through an inhibitory effect o

43 ataxin-3 isoforms differ in their enzymatic deubiquitination activity, subcellular distribution, and

44 hat the overexpression of UCHL1, but not its deubiquitination activity-deficient mutant (UCHL1 C90S),

45 diatric leukaemia, which result in decreased deubiquitination activity.

46 12 and USP46 and is required for the histone deubiquitination activity.

47 hose degradation critically depends on UCH37 deubiquitination activity.

48 terminal domains of EBNA3C contribute to the deubiquitination activity.

49 P7 or USP10 with high affinity and inhibited deubiquitination activity.

50 To prevent deubiquitination after lysis or the copurification of in

51 ome contribute to Lys-48- and Lys-63-linkage deubiquitination, albeit the inhibitory extents are diff

52 This commitment step precedes substrate deubiquitination and allows for selection of ubiquitinat

53 eads to ATPase stimulation, thereby coupling deubiquitination and ATP hydrolysis.

54 protein degradation by catalyzing substrate deubiquitination and by poorly understood allosteric act

55 recruits BAP1 to DNA, promotes local histone deubiquitination and causes changes in target gene activ

56 regulator of NLRP3 activity by promoting its deubiquitination and characterizing NLRP3 as a substrate

57 ase subunit of the proteasome, which couples deubiquitination and degradation of proteasome substrate

58 om this novel enterovirus also showed strong deubiquitination and deISGylation activities and demonst

59 transcriptional gene repression via histone deubiquitination and demethylation.

60 rupts UAF1/FANCI binding and inhibits FANCD2 deubiquitination and DNA repair.

61 a histone H2A deubiquitinase, regulates H2A deubiquitination and gene expression in ESCs, and import

62 ranscriptional activation of FLC through H2B deubiquitination and is consistent with a model in which

63 The mechanisms of PAR(2) deubiquitination and its importance in trafficking and s

64 ibition of HAUSP then led to the loss of p53 deubiquitination and its stabilization in response to ce

65 21 stabilizes FOXP3 protein by mediating its deubiquitination and maintains the expression of Treg si

66 ings reveal unexpected interplay between H2B deubiquitination and nucleosome dynamics.

67 SP37 formed a complex with p27, promoted its deubiquitination and stabilization and blocked cell prol

68 h Axin through its TRAF domain, and promotes deubiquitination and stabilization of Axin.

69 M1 and deubiquitinating enzyme USP5, thereby deubiquitination and stabilization of FoxM1.

70 ifically, we demonstrated that USP7 promotes deubiquitination and stabilization of PHF8, leading to t

71 tion antagonizes this activity, resulting in deubiquitination and stabilization of SMURF1.

72 We also demonstrated that USP2a-dependent deubiquitination and stabilization of the CRY1 protein o

73 SAGA complex regulates telomere function via deubiquitination and stabilization of the telomere repea

74 une regulation that involves OTUD7B-mediated deubiquitination and stabilization of TRAF3.

75 ied, the deubiquitinase responsible for Axin deubiquitination and stabilization remains unknown.

76 interacted with tankyrases to promote their deubiquitination and stabilization.

77 This switch is rate-limiting for deubiquitination and strongly accelerated by mechanical

78 cts with N-Myc, and HAUSP expression induces deubiquitination and subsequent stabilization of N-Myc.

79 This coupling between deubiquitination and substrate degradation is ensured by

80 inactivation, the enzyme(s) involved in H2A deubiquitination and the function of H2A deubiquitinatio

81 hat USP13 is paradoxically required for both deubiquitination and ubiquitination of cohesin subunits

82 sent evidence that USP13 instigates Aurora B deubiquitination and/or protect it from degradation in a

83 suited to coordinate substrate recruitment, deubiquitination, and movement toward the catalytic core

84 lled by a balance between ubiquitination and deubiquitination, and that Cezanne is a key regulator of

85 ated by a balance between ubiquitination and deubiquitination, and that disruption of this balance ca

86 dies now indicate that basal ubiquitination, deubiquitination, and transubiquitination of certain GPC

87 ede1Delta indicates that ubiquitination and deubiquitination are likely to regulate additional compo

88 H2A deubiquitination and the function of H2A deubiquitination are not known.

89 Protein ubiquitination and deubiquitination are post-translational modification pro

90 Appropriate VASP ubiquitination and deubiquitination are required for axon turning in respon

91 mechanisms responsible for their reversible deubiquitination are still poorly understood.

92 Together, our findings identify deubiquitination as a means to regulate BRCA2 function a

93 experimental analyses identified continuous deubiquitination as a prerequisite for maximal substrate

94 Zhang et al. have identified deubiquitination as a signal amplifier.

95 erefore, this study identifies Usp16 and H2A deubiquitination as critical regulators of ESC gene expr

96 chains may not require direct ubiquitination/deubiquitination as is required for proteasome-mediated

97 seem to depend on its polyubiquitination and deubiquitination; as well, the contrasting effects of PS

98 quitination of IRF7 in vivo, but an in vitro deubiquitination assay with purified constituents shows

99 deubiquitinates XPC-ubiquitin conjugates in deubiquitination assays in vitro.

100 hat interacts with Cdu1 and is stabilized by deubiquitination at the chlamydial inclusion.

101 mechanism to prevent the onset of ILV cargo deubiquitination at the initiation of ESCRT-III complex

102 Rpn13/ADRM1 links substrate recruitment with deubiquitination at the proteasome through its proteasom

103 nd reveal a model in which a phosphorylation-deubiquitination axis dynamically regulates RAP80-BRCA1

104 Ets-1 deubiquitination blocks its proteasomal destruction and

105 tment can be regulated by ubiquitination and deubiquitination by E3 ligase and DUB machinery position

106 ress stimulates Cry1 phosphorylation and its deubiquitination by Herpes virus associated ubiquitin-sp

107 Deubiquitination by Rpn11 and ubiquitin unfolding by the

108 In contrast, H2Bub1 deubiquitination by SAGA-associated Ubp8, but not by Ubp

109 cIAP1 rather than to stimulation of IKKgamma deubiquitination by the deubiquitinases A20 and CYLD (cy

110 Ubiquitination by the E3 ligase Nedd4 and deubiquitination by the deubiquitinases USP20 and USP33

111 s, which we developed, that efficient FANCD2 deubiquitination by the USP1-UAF1 complex is dependent o

112 Deubiquitination by ubiquitin-specific protease 2a and A

113 Until now, whether deubiquitination by ubiquitin-specific proteases can reg

114 Thus deubiquitination by Ubp15 counteracts APC activity towar

115 Deubiquitination by Uch37 is activated by proteasomal bi

116 K48 deubiquitination by USP14 is known to inhibit UPS.

117 e evicted from DNA during transcription, for deubiquitination by Usp15.

118 ific deubiquitinase and demonstrate that H2B deubiquitination by USP49 is required for efficient cotr

119 /S50/S525 and WTAP at S306/S341, followed by deubiquitination by USP5, resulting in stabilization of

120 nd reveal a model in which a phosphorylation-deubiquitination cascade dynamically regulates the BRCA2

121 ion has repercussions for ubiquitination and deubiquitination cascades beyond Parkin activation and m

122 y USP2A, USP4, or USP7, other members of the deubiquitination catalytic family.

123 However, whether active deubiquitination co-regulates ubH2A levels in ESCs and d

124 Pharmacological inhibition of NLRP3 deubiquitination completely blocked NLRP3 activation in

125 t3Delta, suppressors in the SWR1 and the H2B deubiquitination complexes show strong functional simila

126 etrograde transport or in the ubiquitination-deubiquitination complexes, are promising candidates as

127 tein involved in mRNA export and histone H2B deubiquitination, contains two introns; non-canonical se

128 Our findings suggest that regulation of deubiquitination could be exploited therapeutically in c

129 a establish a complete PR-ubiquitination and deubiquitination cycle and demonstrate the intricate con

130 telomeres is controlled by a ubiquitination/deubiquitination cycle depending on opposing ubiquitin l

131 ropose that ubiquitination or ubiquitination/deubiquitination cycling specifically regulates later pr

132 the temperature sensitivity and histone H2B deubiquitination defects observed in sus1Delta cells are

133 are regulated and how proteolysis, substrate deubiquitination, degradation, and ATP hydrolysis are co

134 (BMAL1) and reducing its ubiquitylation in a deubiquitination-dependent manner.

135 umoniae-induced NFAT signaling pathway via a deubiquitination-dependent mechanism.

136 nation of TBK1-IKKi independently of the A20 deubiquitination domain.

137 mplex components shows that the SAGA histone deubiquitination (DUB) module lengthened period similarl

138 etyltransferase (HAT) module and the histone deubiquitination (DUB) module.

139 , TBP binding, histone acetylation (HAT) and deubiquitination (DUB).

140 Subsequently, following deubiquitination, enhanced RIM1alpha directly binds to C

141 Here, we identified the deubiquitination enzyme (DUB) USP20 as a pivotal regulat

142 c protein, in which the K63 linkage-specific deubiquitination enzyme AMSH [associated molecule with t

143 mechanism by which Ci/Gli is stabilized by a deubiquitination enzyme and identify Usp7/HUASP as a cri

144 ilitate the deubiquitinating activity of the deubiquitination enzyme BRCC36 or the E3 ligase activity

145 report we show that EBNA3C can function as a deubiquitination enzyme capable of deubiquitinating itse

146 In addition, the deubiquitination enzyme Cylindromatosis (CYLD) negativel

147 A20 harbors a deubiquitination enzyme domain and can employ multiple m

148 ified BRCA1-associated protein-1 (BAP1) as a deubiquitination enzyme for gamma-tubulin.

149 Among these, Cezanne is a known deubiquitination enzyme that inhibits NF-kappaB activity

150 th increased expression of A20, an essential deubiquitination enzyme, and sustained A20-IRAK1 associa

151 These include the deubiquitination enzymes CYLD and A20 that inhibit IKK,

152 Disassembly of the polyubiquitin chains by deubiquitination enzymes prevented TAK1 and IKK activati

153 subunit DNA repair complex, and eventually a deubiquitination event once the DNA repair reaction has

154 ted the importance of dynamic ubiquitination-deubiquitination events in regulating this canonical NF-

155 supporting the requirement of ubiquitination/deubiquitination for normal synaptic development and rep

156 that contain ubiquitin-binding domains, and deubiquitination govern the itineraries of cargo protein

157 Deubiquitination has emerged as an essential regulatory

158 Histone H2B ubiquitination and deubiquitination have been implicated in transcriptional

159 dies aiming to understand ubiquitination and deubiquitination have employed unanchored ubiquitin chai

160 feedforward loop of NLRC5 ubiquitination and deubiquitination, highlighting a new pathway modulating

161 itinase and uncovers a critical role for H2B deubiquitination in cotranscriptional pre-mRNA processin

162 USP52 and the regulatory complexity of CtIP deubiquitination in DNA repair.

163 ared with the WT, thus affirming the role of deubiquitination in GCGR recycling.

164 gesting a novel mechanism regulating histone deubiquitination in higher organisms.

165 P1 can substitute for that of UAF1 in FANCD2 deubiquitination in our biochemical system.

166 is work, we describe the role of histone H2B deubiquitination in the activation of gene expression an

167 f DNA binding by UAF1 and RAD51AP1 in FANCD2 deubiquitination in the cellular setting.

168 assays revealed that USP12 regulates histone deubiquitination in the mesoderm and at specific gene pr

169 consequence of a perturbation of histone H2B deubiquitination in the timing of the floral transition

170 the phosphorylation of AKT, which led to the deubiquitination, increased stability and nuclear accumu

171 Overall, we demonstrate a novel, deubiquitination-independent function for USP14 in influ

172 regulates synaptic function through a novel, deubiquitination-independent mechanism.

173 We show that deubiquitination inhibited the NLRP6-ASC inflammasome co

174 Deubiquitination is a critical event required for Fancd2

175 Interestingly, p97-associated deubiquitination is also involved in degradation of a so

176 At the proteasome, deubiquitination is an essential preprocessing event tha

177 This ubiquitination-deubiquitination is conceptually reminiscent of the gluc

178 to ataxin-3, further explaining how ataxin-3 deubiquitination is coupled to parkin ubiquitination.

179 n the first 205 residues of the protein, and deubiquitination is dependent on a cysteine at position

180 Previous studies suggest that SPRTN deubiquitination is important for its chromatin associat

181 tion and is consistent with a model in which deubiquitination is necessary for the accumulation of H3

182 iptional regulation, but the function of H2B deubiquitination is not well defined, particularly in hi

183 Rapid deubiquitination is required for efficient degradation b

184 activation in T cells, the regulation of its deubiquitination is unclear.

185 The reversal of ubiquitination, or deubiquitination, is equally critical to neuronal functi

186 is redundant with that of RAD51AP1 in FANCD2 deubiquitination, it is required for efficient HR-mediat

187 To measure H2B ubiquitylation and deubiquitination kinetics in vivo, we used a rapid and r

188 RNA knockdown of AMSH or UBPY also impaired deubiquitination, lysosomal trafficking, and degradation

189 ellular vesicle (EV) cargo to manipulate the deubiquitination machinery of the human microglial cell

190 n and characterization of ubiquitination and deubiquitination machinery that regulate NF-kappaB.

191 Our results suggest that histone H2A deubiquitination may account, at least in part, for the

192 Our study establishes a deubiquitination mechanism catalyzed by a deamidase, whi

193 uggest that NLRP3 is activated by a two-step deubiquitination mechanism initiated by Toll-like recept

194 tion of NLRP3 inflammasome is regulated by a deubiquitination mechanism.

195 eceptors, drives rapid, CYLD-mediated PSD-95 deubiquitination, mobilizing and depleting PSD-95 from s

196 s the formation of a quaternary complex, the deubiquitination module (DUBm) of SAGA, which is compose

197 The deubiquitination module (DUBm) of the SAGA complex is a

198 acetylase complex, the SWR1 complex, the H2B deubiquitination module of SAGA, the proteasome, Set1, a

199 Usp22, a member of the deubiquitination module of the SAGA chromatin-modifying

200 Consistent with a functional role for deubiquitination, mutation of the cytoplasmic lysines of

201 We report that receptor deubiquitination occurs between early endosomes and lyso

202 ntagonizes Nedd4-1 function by promoting the deubiquitination of AMPARs.

203 ar mechanisms involved in ubiquitination and deubiquitination of AMPARs.

204 USP33) binds beta-arrestin2 and leads to the deubiquitination of beta-arrestins.

205 tin-specific proteases (USPs) that carry out deubiquitination of cellular substrates are poorly under

206 located in early endosomes and regulates the deubiquitination of CFTR and its trafficking in the post

207 novel function for USP10 in facilitating the deubiquitination of CFTR in early endosomes and thereby

208 Deubiquitination of FANCD2 is mediated by the ubiquitin

209 n this pathway is the monoubiquitination and deubiquitination of FANCD2.

210 Monoubiquitination and deubiquitination of FANCD2:FANCI heterodimer is central

211 Therefore, Wnt-induced deubiquitination of FoxM1 represents a novel and critica

212 TMEM79 specifically inhibits USP8 deubiquitination of FZD, thereby governing USP8 substrat

213 ncovers a new mechanism for BAP1 involved in deubiquitination of gamma-tubulin, which is required to

214 recycling endosomes, but also induced rapid deubiquitination of GCGRs.

215 st single gene disorder linked to defects in deubiquitination of H2AK119Ub1 and suggests an important

216 sphorylated H2AY57 (H2AY57p), which inhibits deubiquitination of H2B by the SAGA complex as well as r

217 Deubiquitination of H2B by the Spt-Ada-Gcn5 acetyltransf

218 red for interaction with HCF-1N and mediates deubiquitination of HCF-1N by BAP1.

219 m to the nucleus from the cytosol to control deubiquitination of histone H2B and spliceosomal protein

220 One role is deubiquitination of histone H2B, and this activity resid

221 d pro-inflammatory polarization, and reduced deubiquitination of IL-1alpha protein.

222 We further show that deubiquitination of ILV cargoes is inhibited via Doa4 bi

223 work uncovers a novel role for USP8-mediated deubiquitination of K6-linked ubiquitin conjugates from

224 Rather, SGTA actively promotes the deubiquitination of mislocalized proteins that are alrea

225 ed suppression of cell proliferation but not deubiquitination of monoubiquitinated histone 2A lysine

226 Thus, by mediating USP10-dependent deubiquitination of NEMO, MCPIP1 induction serves as a n

227 NF-kappaB activity and demonstrate that the deubiquitination of NF-kappaB by USP7 is critical for ta

228 USP7 deubiquitination of NF-kappaB leads to increased transcr

229 r show that signaling by ATP can also induce deubiquitination of NLRP3 by a mechanism that is not sen

230 both mouse and human cells, indicating that deubiquitination of NLRP3 is required for its activation

231 ted I50 [malate and Asp] values) via in vivo deubiquitination of p110 to p107, and subsequent phospho

232 action, resulting in enhanced USP10-mediated deubiquitination of p53, and consequently increased p53

233 Moreover, ataxin-3-dependent deubiquitination of parkin required the catalytic cystei

234 ls and led to cell death, presumably through deubiquitination of PCNA and the inability to repair dam

235 Importantly, deubiquitination of PCNA could be detected endogenously

236 Thus, deubiquitination of PCNA, normally deubiquitinated by ce

237 Deubiquitination of PLK4 facilitates its binding to and

238 he deubiquitinase CYLD to the centrosome for deubiquitination of polo-like kinase 4 (PLK4), the maste

239 activity is inhibited to prevent unwarranted deubiquitination of polyubiquitinated proteins.

240 RAD51 hinders RAD51-BRCA2 interaction, while deubiquitination of RAD51 facilitates RAD51-BRCA2 bindin

241 Ubiquitination and deubiquitination of receptor-interacting protein 1 (RIP1

242 , a ubiquitin-editing enzyme responsible for deubiquitination of RIP1 and subsequent termination of N

243 uggesting a positive role for USP15-mediated deubiquitination of RORgammat in Th17 differentiation.

244 3BP1-family-USP10 complexes are required for deubiquitination of RPS2, RPS3, and RPS10 to rescue modi

245 Collectively, active deubiquitination of RUNX2 is required for bone formation

246 d a complex with Smad7 that facilitated CYLD deubiquitination of Smad7 at lysine 360 and 374 residues

247 T cells and the development of Tregs through deubiquitination of Smad7.

248 TGF-beta-induced pro-oncogenic responses via deubiquitination of SMAD7.

249 Ubp8-mediated deubiquitination of Snf1 affects the stability and phosp

250 tylation, methylation and demethylation, and deubiquitination of specific amino acid residues in hist

251 Deubiquitination of SPRTN is required for its subsequent

252 nd showed a substantial defect in the linear deubiquitination of target molecules.

253 Our results suggest that deubiquitination of the activator is critical for transc

254 ocytic trafficking prevented agonist-induced deubiquitination of the GCGR.

255 4 and USP14 is paralleled by USP14-catalyzed deubiquitination of the receptor; knockdown of endogenou

256 pathway dependent on the export in Xpo1p and deubiquitination of the RNAPI large subunit Rpa190p by U

257 ATP-dependent, degradation-coupled deubiquitination of the substrate is required both for e

258 urvival and growth of prostate cancer cells, deubiquitination of these sites has an equally important

259 t with conformational plasticity, permitting deubiquitination of three of the most abundant polyubiqu

260 e Tip60 stability by promoting USP7-mediated deubiquitination of Tip60.

261 deubiquitinating enzyme and is required for deubiquitination of TRAF6, thus limiting RANKL-induced o

262 ances Usp15 binding to ubH2B and facilitates deubiquitination of ubH2B in free histones but not in nu

263 edented flexibility and precision to measure deubiquitination of virtually any (poly)Ub conjugate.

264 HlyA also promotes deubiquitination, oligomerization, and activation of the

265 0 can directly impair IKK activation without deubiquitination or impairment of ubiquitination enzymes

266 quired for bone formation and this CK2/HAUSP deubiquitination pathway offers therapeutic opportunitie

267 that it is also likely to be targeted by the deubiquitination pathway.

268 nal modifications, including ubiquitination, deubiquitination, phosphorylation, and degradation contr

269 1) as a component of the Polycomb repressive deubiquitination (PR-DUB) complex.

270 Post-translational ubiquitination and deubiquitination processes involving the AMSH1 deubiquit

271 18 function and suggest that damage-specific deubiquitination promotes a switch from Rad18*Ub-Rad18 c

272 n USP30 knockout (KO) cells, suggesting that deubiquitination promotes efficient import.

273 The deubiquitination-promoting effect of ASXM requires intra

274 nd is required for iNOS interaction with the deubiquitination protein UCH37.

275 We further followed the deubiquitination reaction of Ub-AMC and K48-linked IQF-d

276 egulated by cycles of autoubiquitination and deubiquitination, reactions that are modulated by the ot

277 change of histone H2A monoubiquitination and deubiquitination reflects the succession of transcriptio

278 Deubiquitination regulates formation of endocytic sites

279 A balance between ubiquitination and deubiquitination regulates numerous cellular processes a

280 er, the regulation and consequences of SPRTN deubiquitination remain unclear.

281 ecular mechanism underpinning its reversible deubiquitination remains poorly defined.

282 whether or not they can also mediate histone deubiquitination remains unknown.

283 F1 complex also deubiquitinates PCNA-Ub, and deubiquitination requires the PCNA-binding protein hELG1

284 s deubiquitinating activity for IkappaBalpha deubiquitination, resulting in excessive NF-kappaB activ

285 enses downstream events, while timely FANCD2 deubiquitination serves to extinguish the response.

286 Consequently, USP8-mediated deubiquitination slows progression of EGFR past the earl

287 model, wherein a cycle of H2B ubiquitination/deubiquitination specifies Ser2P to regulate elongation

288 The ubiquitination and deubiquitination status of PRP31 regulates its interacti

289 e for ubiquitinated proteins and links their deubiquitination to their degradation.

290 e commitment are fast relative to subsequent deubiquitination, translocation, and unfolding.

291 hanistic implications for substrate binding, deubiquitination, unfolding, and degradation.

292 CRY1 and enhances its protein stability via deubiquitination upon serum shock.

293 Through deubiquitination, USP13 stabilizes and upregulates MITF

294 Through its effects on MITF deubiquitination, USP13 was observed to modulate express

295 P13) that appears to be responsible for MITF deubiquitination, utilizing a short hairpin RNA library

296 Altogether, targeted deubiquitination via enDUBs provides a powerful protein

297 Reduction in the levels of deubiquitination was also observed in cells infected wit

298 ociation and subsequent USP20-mediated TRAF6 deubiquitination were beta-arrestin2-dependent.

299 fficking at recycling endosomes enabled GCGR deubiquitination, whereas a Rab5a DN that blocks traffic

300 SP14 by RNA interference (RNAi) blocks CXCR4 deubiquitination, whereas overexpression of USP14 promot

301 monious use of molecular contacts to achieve deubiquitination, with less than 1,000 A(2) of accessibl