ライフサイエンスコーパス: developmental gene

1 t encoded by EARLY FLOWERING 3 (ELF3), a key developmental gene.

2 e, with gradual hypermethylation of bivalent developmental genes.

3 27me3), particularly at CGIs associated with developmental genes.

4 the DPY30-COMPASS histone modifiers onto key developmental genes.

5 cle regeneration, and derepression of muscle developmental genes.

6 d PRC2 are well known for silencing specific developmental genes.

7 s for tissue growth and directly targeted by developmental genes.

8 PRC2 and poised RNAPII at Erk2-PRC2-targeted developmental genes.

9 s in their content of neurogenic, immune and developmental genes.

10 ently are located megabases away from target developmental genes.

11 AT signaling, NF-kappaB signaling and B cell developmental genes.

12 cross animals, many of which are enriched in developmental genes.

13 dhesion proteins, and in the upregulation of developmental genes.

14 ponse and late expression of several "early" developmental genes.

15 enhancers, which regulate expression of key developmental genes.

16 signals modulate RNAi silencing to regulate developmental genes.

17 ciated regulatory factors (RFs) at important developmental genes.

18 transferase that regulates the expression of developmental genes.

19 ty of this important regulator of M. xanthus developmental genes.

20 rn, regulates the expression of a variety of developmental genes.

21 elopment by directly regulating a set of key developmental genes.

22 Ring1b subunit of PRC1 and TBP co-enrich at developmental genes.

23 gnaling, and (d) inappropriate expression of developmental genes.

24 portant but redundant or partially redundant developmental genes.

25 ne expression - specifically at the bivalent developmental genes.

26 ion and thereby regulates cell type-specific developmental genes.

27 at" that finely calibrates PRC2 functions at developmental genes.

28 h H3K27me3 and H3K4me2), a characteristic of developmental genes.

29 to provide specificity to activation of key developmental genes.

30 eptor, a transcription factor that regulates developmental genes.

31 ign and successfully applied them to several developmental genes.

32 reversible PcG function is essential at most developmental genes.

33 specific transcription factors and represses developmental genes.

34 mechanism for the spatiotemporal control of developmental genes.

35 arrays), and pathogenic sequence variants in developmental genes.

36 in the detection of several known and novel developmental genes.

37 3a and Dnmt3b resulted in failure to silence developmental genes.

38 can activate or repress transcription of key developmental genes.

39 to sequential reprogramming of metabolic and developmental genes.

40 ates a redeployment of mesenchyme-associated developmental genes.

41 the maintenance of transcriptionally poised developmental genes.

42 ember of the T-box gene family of mesodermal developmental genes.

43 results from aberrant expression of cardiac developmental genes.

44 erentially regulating "housekeeping" versus "developmental" genes.

45 , we uncover novel relatedness of particular developmental genes across different organs and tissues

46 omains are considered to poise expression of developmental genes, allowing timely activation while ma

47 cleosomes regulates the origins that mediate developmental gene amplification during Drosophila oogen

48 Here, we use developmental gene amplification in Drosophila ovarian f

49 ng the activation of origins responsible for developmental gene amplification in Drosophila.

50 sis, both via epigenetic regulation of a key developmental gene and by promoting genome stability in

51 They cluster around developmental genes and act as long-range enhancers, yet

52 ers decreases gene expression in a subset of developmental genes and alters ESC differentiation, wher

53 anchors regulate some of the most important developmental genes and are less likely to be expressed

54 ily conserved sequences, are associated with developmental genes and are marked with active enhancer

55 MLL2/COMPASS methylates H3K4 on many developmental genes and bivalent clusters.

56 K27me3, and PHF19/PCL3 at a subset of poised developmental genes and demonstrated that PHF19/PCL3 Tud

57 n positive and negative correlations between developmental genes and developmental processes or cell

58 ecific transcriptional "memory" of embryonic developmental genes and exhibited differential promoter

59 associated with birth weight were linked to developmental genes and have methylation levels which ar

60 tem cells (mESCs) causes the derepression of developmental genes and induction of early differentiati

61 pressive complex 2 (PRC2) places H3K27me3 at developmental genes and is causally implicated in keepin

62 the dHP1c complex, localizes at promoters of developmental genes and is required for transcription.

63 scle proteins and upregulation of oncogenes, developmental genes and lungfish LSGs.

64 ound the transcriptional start site (TSS) of developmental genes and mediates the recruitment of the

65 lls by altering the expression timing of key developmental genes and pluripotent genes.

66 Expression of mucins and developmental genes and proliferation were assessed by i

67 regulating distinct chromatin states at key developmental genes and propose a novel mechanism by whi

68 h cryptic introns to form heterochromatin at developmental genes and retrotransposons, Ctr1 functions

69 trajectories of transposable elements (TEs), developmental genes and sex chromosomes onto the snake p

70 s deficiency leads to impaired activation of developmental genes and subsequent embryonic lethality.

71 models, the identification of specific renal developmental genes and the application of novel sequenc

72 The rapid evolution of essential developmental genes and their protein products is both i

73 ands of human-specific genome alterations in developmental genes and their regulatory regions.

74 This up-regulation affects many developmental genes and transcription factors, including

75 Dysregulation of the developmental gene anterior gradient protein 2 (AGR2) ha

76 In contrast, we observed that developmental genes are acutely up-regulated after cycli

77 which transcriptional enhancers controlling developmental genes are contained within nearby bystande

78 Developmental genes are essential in the formation and f

79 Developmental genes are often controlled by large regula

80 CD was originally identified as an essential developmental gene associated with mRNA and Golgi-endopl

81 very and validation of Aldh1a2, an essential developmental gene associated with various important car

82 2A (H2A(ub)) and is associated with silenced developmental genes at facultative heterochromatin.

83 analyzed the gene expression patterns of 96 developmental genes at single-cell resolution.

84 hylation with a lower expression of specific developmental genes at stage 5 raises the possibility th

85 valleys, hypomethylated domains encompassing developmental genes, become methylated with concomitant

86 to alterations in expression of the critical developmental gene bldN, and other key downstream genes

87 Morphology evolves often through changes in developmental genes, but the causal mutations, and their

88 ditis elegans complexes that repress pivotal developmental genes, but the mammalian complex has been

89 ulatory gains near transcription factors and developmental genes, but this trend was replaced by inno

90 Oct1 and Sox2 synergistically regulate developmental genes by binding to adjacent sites within

91 Repression of the developmental genes by mTOR is necessary for the mainten

92 gy and identity, including regulation of all developmental genes, cell differentiation, stem and soma

93 Other cardiac developmental gene classes have less stratification by m

94 tism spectrum disorder (ASD) affect distinct developmental gene co-expression modules.

95 hibit significantly increased enrichment for developmental genes compared with differentially methyla

96 of pluripotency genes and underexpression of developmental genes during differentiation in the absenc

97 ion, as a component of the bivalent mark, at developmental genes during the ESC fate transitions.

98 Bivalency of developmental genes during the G1 phase of the pluripote

99 ore open-chromatin conformation at key heart developmental genes, enabling their promoters and enhanc

100 expression characteristic of their proximal developmental gene, even in the absence of sequence cons

101 Understanding how changes in developmental gene expression alter morphogenesis is a f

102 The genetic basis for divergence in developmental gene expression among species is poorly un

103 A recent study compares developmental gene expression among very distantly relat

104 trates removal of H3K27me3, thus controlling developmental gene expression and cell differentiation.

105 o intracellular inputs that in turn regulate developmental gene expression and coordinate patterned t

106 ly related sea urchins with highly divergent developmental gene expression and life histories.

107 was substantially slowed with delayed early developmental gene expression and that chemotaxis toward

108 ole as a transcription regulator controlling developmental gene expression are unknown.

109 ies data sets to determine the regulation of developmental gene expression by cell cycle, lineage, mo

110 ecerebellar nucleus in the mouse that shares developmental gene expression characteristics with mossy

111 tor machine (SVM) model, trained using brain developmental gene expression data, for the classificati

112 echniques to the EPIC single-cell-resolution developmental gene expression dataset for C. elegans fro

113 echniques to the EPIC single-cell-resolution developmental gene expression dataset for Caenorhabditis

114 rnative sigma factors governs the program of developmental gene expression during sporulation in Baci

115 vironmental sensing, signal transduction and developmental gene expression in a coherent pathway.

116 xts, a direct link between B-type lamins and developmental gene expression in an in vivo system is cu

117 Live imaging of developmental gene expression in Drosophila embryos open

118 ins play an important role in the control of developmental gene expression in higher organisms.

119 abling sigma(F), promotes the switch to late developmental gene expression in the forespore.

120 Thus, precise spatiotemporal control of developmental gene expression is achieved by complex mul

121 For instance, developmental gene expression is extremely similar in a

122 o distinct degradation rates, I propose that developmental gene expression is shaped by a complex 'mR

123 that a variety of human cancers recapitulate developmental gene expression patterns (that is activate

124 In particular, for the analysis of developmental gene expression patterns, it is biological

125 d chromatin looping can override a stringent developmental gene expression program and suggest a nove

126 tiprotein complexes to counteract repressive developmental gene expression programmes established by

127 States vary in developmental gene expression programs and display disti

128 PRDM16 regulates convergent developmental gene expression programs in the cortex and

129 er chromatin-modifying activities to control developmental gene expression programs remain unclear.

130 with condensed chromatin and fine-tuning of developmental gene expression programs, is positively co

131 ments required for specialized cell-type and developmental gene expression programs.

132 egions with proliferating cells enriched for developmental gene expression programs.

133 Developmental gene expression results from the orchestra

134 mal pausing helps confer tissue-specific and developmental gene expression through a mechanism regula

135 ptomes revealed a high rate of divergence in developmental gene expression, but also several genes wi

136 s two-tiered mechanism globally orchestrates developmental gene expression, including extremely wides

137 Although both are required for developmental gene expression, receptor occupancy promot

138 ng chromatin features required for regulated developmental gene expression.

139 coronary blood vessel formation, and altered developmental gene expression.

140 ows users to perform online queries of mouse developmental gene expression.

141 (PITX2) homeodomain protein, which modulates developmental gene expression.

142 ubpallium have been proposed using conserved developmental gene expression.

143 of repressed chromatin domains and regulate developmental gene expression.

144 Morphological characters are the result of developmental gene expression.

145 nome reprogramming, cell differentiation and developmental gene expression.

146 onmental cues, and respond by changing their developmental gene expression.

147 tion patterns are strongly correlated with a developmental gene expression.

148 ed analysis of transcription factor (TF) and developmental-gene expression in the SCN from neurogenes

149 timing of colonization, and had a different developmental gene-expression program.

150 sease-related genes and the potential of one developmental gene for disease susceptibility in rice/Xo

151 op of a hierarchy of interactions by marking developmental genes for activation, beginning with the o

152 of pluripotency-associated genes, and primes developmental genes for differentiation.

153 Together BldO and BldD repress developmental genes from being expressed until the appro

154 2 functions in gene expression by protecting developmental genes from repression via repelling PRC2 a

155 tion in zebrafish can accelerate the pace of developmental gene function discovery.

156 ve expression pattern analysis of homologous developmental genes has been a successful approach to cl

157 ansmission and transcriptional activation of developmental genes, has potential as a bio-pesticide to

158 Despite their importance, however, many developmental genes have yet to be identified.

159 controlling the activation and silencing of developmental genes; however, the mechanistic details of

160 ions followed by transcriptional analysis of developmental genes identified four distinct candidate p

161 rs also had transcriptional dysregulation of developmental genes implicated in autism and schizophren

162 explain the sharp expression of a canonical developmental gene in response to a regulating transcrip

163 e required for the epigenetic maintenance of developmental genes in a silent state.

164 by Polycomb, H3K27me3, is maintained at key developmental genes in diapause, and the Polycomb member

165 mb Repressive Complex 2 (PRC2) regulates key developmental genes in embryonic stem (ES) cells and dur

166 bivalent chromatin mark that typifies poised developmental genes in embryonic stem cells (ESCs).

167 PRC1-Br140 bind developmental genes in fly embryos, with analogous co-oc

168 ss functional tools available to study early developmental genes in insects, and provide examples in

169 translocations to cause excess expression of developmental genes in leukemia.

170 mic regions devoted to cis-regulation of key developmental genes in Metazoa.

171 Developmental genes in metazoan genomes are surrounded b

172 (PRC1) and PRC2 maintain repression at many developmental genes in mouse embryonic stem cells and ar

173 activation in promoting the primed status of developmental genes in mouse ES cells and suggest that t

174 that modulates expression of many important developmental genes in Myxococcus xanthus.

175 , intrinsic differences in the expression of developmental genes in regional adipocytes provide a mec

176 heterochromatin needed for the silencing of developmental genes in the adult heart.

177 uggesting the specialized packaging of these developmental genes in the germline.

178 od by perturbing 40 previously characterized developmental genes in variants of the two strains conta

179 ize to the promoters of a specific subset of developmental genes in vivo, the SLED domain of Scml2 ma

180 y members in the regulation of several early developmental genes including homeobox transcription fac

181 signaling genes and contained cardiovascular developmental genes including TBX5.

182 nd the expression of specific cell cycle and developmental genes, including growth-regulating factors

183 te nucleosomes to maintain repression of key developmental genes, including Hox genes whose temporal

184 ZMYND8 was found to be recruited to several developmental genes, including the all-trans-retinoic ac

185 ed as a model organism for investigating the developmental gene interactions.

186 ins are normally required to sequester early developmental genes into architecturally inaccessible ge

187 ulatory subunit 12a (PPP1R12A), an important developmental gene involved in cell migration, adhesion,

188 Colletotrichum gloeosporioides COM1 (CgCOM1) developmental gene involved in the fungal conidial and a

189 Epigenetic modifications regulate developmental genes involved in stem cell identity and l

190 Further analyses on several developmental genes involved in the photoreceptor cell d

191 the epigenetically poised condition of these developmental genes is a fundamental property of the mam

192 Activation of developmental genes is coincident with PTIP protein bind

193 nd suggest that the transcription complex at developmental genes is different than the complexes form

194 combination of the expression levels of the developmental genes is strongly correlated with the deve

195 e category of promoters, associated with key developmental genes, is frequently hypermethylated in ca

196 , visualized by changes in the expression of developmental genes like engrailed or cubitus interruptu

197 nteraction profiles and nuclear positions at developmental gene loci differ between human somatic cel

198 27 trimethylation (H3K27me3) on chromatin at developmental gene loci in mouse embryonic stem cells.

199 priately respond to differentiation signals, developmental gene loci should be structurally and spati

200 Moreover, we also demonstrate that developmental gene loci, which have bivalent histone mod

201 o the regulatory regions of pluripotency and developmental genes marked with H3K27me3 contributing to

202 ression, and that the regulation of neuronal developmental genes may be the most ancient and conserve

203 ures at poised genes, particularly those key developmental genes mediated by BAF250a.

204 The sequential activation of distinct developmental gene networks governs the ultimate identit

205 their relationship is to core components of developmental gene networks, and what is the development

206 lts highlight complexity in the evolution of developmental gene networks: changing protein-protein in

207 nes (Th, Gad1), as well as changes in neural developmental genes (Nurr, Ncam).

208 Recent reports have shown that developmental genes often possess multiple discrete enha

209 ution, the evolutionary rates of early-stage developmental genes, or on species diversification.

210 ifications/compositions genome-wide and find developmental genes packaged in large blocks of chromati

211 the adult heart results in reactivation of a developmental gene program in the epicardium, but the tr

212 mant after birth, cardiac injury reactivates developmental gene programs that stimulate epithelial-to

213 brosis, show evidence of a recapitulation of developmental gene programs.

214 ryonic stem cells (ESCs), a subset of silent developmental gene promoters are primed for activation b

215 Methylation of developmental gene promoters during tumorigenesis may th

216 histone H3 at lysine 4 (H3K4me3) emerges at developmental gene promoters in E6.5 Epi and positively

217 argely associated with a subset of essential developmental gene promoters, which are located within C

218 are associated with a particular set of key developmental gene promoters.

219 rtially methylated domains (PMDs) and occupy developmental gene promoters.

220 These findings support the concept of developmental gene re-activation in IPF, and FGF-10 defi

221 omb repressive complex 2 (PRC2) placement at developmental genes regulated by silencing in Arabidopsi

222 res bivalent epigenetic modifications of key developmental genes regulated by various transcription f

223 use of its value to enlighten the biology of developmental gene regulation and because fetal hemoglob

224 nts is therefore important for understanding developmental gene regulation and disease.

225 can now test these sequences for effects on developmental gene regulation and downstream phenotypes

226 poson regulation, heterochromatin formation, developmental gene regulation and genome stability.

227 represents a classical model system to study developmental gene regulation in mammalian cells.

228 mplexes PRC1 and PRC2 play a central role in developmental gene regulation in multicellular organisms

229 ucleosome positional changes associated with developmental gene regulation in WT.

230 ologists to address fundamental questions of developmental gene regulation on a genome-wide scale.

231 Appropriate developmental gene regulation relies on the capacity of

232 his work introduces a hierarchical model for developmental gene regulation, and reveals a major role

233 Epigenetic information plays a role in developmental gene regulation, response to the environme

234 chromatin conformation and TAD integrity on developmental gene regulation, we have manipulated the S

235 anner, providing a multitiered mechanism for developmental gene regulation.

236 -directed gene repositioning is critical for developmental gene regulation.

237 are linked to transcriptional repression and developmental gene regulation.

238 a functional role for 3' CGI methylation in developmental gene regulation.

239 animal development, with widespread roles in developmental gene regulation.

240 riptional corepressors play complex roles in developmental gene regulation.

241 represents a clinically important example of developmental gene regulation.

242 ions, indicating a general role for MrpC2 in developmental gene regulation.

243 ation of ATS class can be a critical mode of developmental gene regulation.

244 een chromatin state and accessibility during developmental gene regulation.

245 Nuclear FGFR1 acts as a developmental gene regulator in cooperation with FGF-2,

246 pecific scUMCs are associated with essential developmental genes, regulators of cell differentiation,

247 data help further elucidate the link between developmental gene regulatory mechanisms and transcripti

248 In an A. thaliana developmental gene regulatory network, GRACE recovers ce

249 ore promoter functions in the dorsal-ventral developmental gene regulatory network.

250 Developmental gene regulatory networks (GRNs) are assemb

251 Comparisons of orthologous developmental gene regulatory networks (GRNs) from diffe

252 Developmental gene regulatory networks (GRNs) must there

253 lems in biology, from theoretical aspects of developmental gene regulatory networks (GRNs) to various

254 evolutionary changes that have restructured developmental gene regulatory networks (GRNs).

255 s occurred by alteration of the structure of developmental gene regulatory networks.

256 anism of BCL11A action and new clues for the developmental gene regulatory programs that function at

257 , by alterations in the structure of encoded developmental gene-regulatory networks (GRNs).

258 ns assemble a chromatin state that maintains developmental gene repression.

259 set of bivalent genes silent in mESCs, while developmental genes require MSL for expression during di

260 tes largely from the spatial redeployment of developmental genes [S.

261 ects due to missense mutations in additional developmental genes seem to enhance the phenotypic varia

262 Key developmental gene sets are actively repressed outside o

263 stone H3 (H3K27me3) is intimately related to developmental gene silencing through the so-called Polyc

264 , the Polycomb Group (PcG) proteins maintain developmental gene silencing using an array of chromatin

265 neuroepithelium expressing a combination of developmental genes: Six3, Six6, Fzd5, and transient Rx,

266 They express other developmental genes, such as Pdx-1 and Hes-1.

267 possibility of sex-biased expression of key developmental genes, such as the segmentation genes cont

268 T-DMR-associated genes were enriched for developmental genes, suggesting that a specific set of a

269 First, DNA hypomethylation at embryonic developmental genes supports their epigenetic "poising"

270 hes1 is a key developmental gene that is overexpressed in certain canc

271 ture is the poised chromatin state of master developmental genes that are transcriptionally repressed

272 ure, bilaterian animals share common sets of developmental genes that display conserved expression pa

273 These enhancers are linked to developmental genes that display coordinated transcripti

274 e discovered a group of CGIs associated with developmental genes that gain methylation after hESCs di

275 Notably, it is enriched among key developmental genes that have bivalent chromatin structu

276 lt-onset, age-associated events by silencing developmental genes that later have a deleterious influe

277 ts influencing putamen volume clustered near developmental genes that regulate apoptosis, axon guidan

278 jury to the adult kidney induces a number of developmental genes thought to regulate repair, includin

279 KDM2B repressed developmental genes through cobinding with Polycomb grou

280 silencing the expression of essential fungal developmental genes to inhibit the growth of pathogenic

281 Homeobox proteins are critical regulators of developmental gene transcription and cell specification.

282 operatively to promoter regions and activate developmental gene transcription, including that of the

283 ajor Trl cofactor that functions to moderate developmental gene transcription.

284 und homeodomain factor effectively activates developmental gene transcriptional programs.

285 system of flies and mammals, whereby various developmental genes undergo coordinate 3' UTR extension.

286 ts in the deployment and effects of a single developmental gene underlie morphological change.

287 K56Ac then relocates to developmental genes upon cellular differentiation.

288 hRPCs showed the expression of early retinal developmental genes: VIM (vimentin), KI67, NES (nestin),

289 as cultured, and expression of key beta-cell developmental genes was assessed by QRT-PCR.

290 hibited, expression of a number of conceptus developmental genes was not altered.

291 essed in early development and suppress late developmental genes), we hypothesized that the silencing

292 Streptomyces, repressing a large regulon of developmental genes when the bacteria are growing vegeta

293 d gene bodies of Polycomb group (PcG) target developmental genes, while Dnmt3b has a dominant role on

294 ontaining H3K4me3 and H3K27me3 marks silence developmental genes, while keeping them poised for activ

295 The Polycomb module represses developmental genes, while the Myc module is associated

296 sting post-fertilisation reprogramming marks developmental genes whose expression is perturbed upon e

297 s.SIGNIFICANCE STATEMENT Dscaml1 is a neural developmental gene with unknown behavioral significance.

298 ubset represents a novel class of chlamydial developmental genes with features of both early and midc

299 ived cell migration and re-expression of the developmental gene wt1b was impaired.

300 These developmental gene x environment interactions tune circa