ライフサイエンスコーパス: diacylglycerol

1 messengers inositol 1,4,5-trisphosphate and diacylglycerol.

2 sis, the esterification of fatty acyl-CoA to diacylglycerol.

3 ch of the two substrates, fatty acyl-CoA and diacylglycerol.

4 oil contents by transferring HFA from PC to diacylglycerol.

5 c stimulation with the physiological agonist diacylglycerol.

6 ate, phosphatidate, and reduces the product, diacylglycerol.

7 effectors in signaling pathways regulated by diacylglycerol.

8 glycerol kinase, resulting in an increase in diacylglycerol.

9 messengers inositol 1,4,5-trisphosphate and diacylglycerol.

10 ospholipase-C, apparently not acting through diacylglycerol.

11 phatidylcholine and galactolipids to produce diacylglycerol.

12 functional C1 domain and is not regulated by diacylglycerol.

13 ion of phosphatidic acid and, paradoxically, diacylglycerol.

14 levations in free fatty acids, ceramides and diacylglycerols.

15 Although enriched in diacylglycerol, 10:0 was not detected in phosphatidylcho

16 kinase (DGK) produces PA by phosphorylating diacylglycerol, a crucial step in PA metabolism.

17 nstream of ZAP70 recruitment and upstream of diacylglycerol accumulation.

18 Euonymus alatus diacylglycerol acetyltransferase (EaDAcT) catalyzes the

19 multimer channels with TRPC6 and function as diacylglycerol-activated cation channels coordinately, t

20 terning is evident as annexin A1, dysferlin, diacylglycerol, active Rho, and active Cdc42 are recruit

21 mutant dgat1-1 (in which phosphatidylcholine:diacylglycerol acyltransferase (AtPDAT1) is the major TA

22 lglycerol synthesis is catalysed by acyl-CoA diacylglycerol acyltransferase (DGAT) enzymes(2-4), the

23 seeds, two evolutionarily unrelated acyl-CoA:diacylglycerol acyltransferase (DGAT) enzymes, DGAT1 and

24 glycerides (TGs) synthesized by two acyl-CoA:diacylglycerol acyltransferase (DGAT) enzymes.

25 Kinetically improved diacylglycerol acyltransferase (DGAT) variants were crea

26 3-phosphate acyltransferase (GPAT), acyl-CoA:diacylglycerol acyltransferase (DGAT), and phospholipid:

27 A pool, making these PUFAs available for the diacylglycerol acyltransferase (DGAT)-catalyzed reaction

28 g chemical and genetic approaches to disrupt diacylglycerol acyltransferase (DGAT)-dependent LD bioge

29 thesis, such as the integral membrane enzyme diacylglycerol acyltransferase (DGAT).

30 lation of sn-1,2-diacylglycerol catalyzed by diacylglycerol acyltransferase (DGAT, EC 2.3.1.20).

31 nes of a lead optimization effort to develop diacylglycerol acyltransferase (DGAT1) inhibitors.

32 PHOSPHOLIPID:DIACYLGLYCEROL ACYLTRANSFERASE (PDAT) is an enzyme that

33 ROL ACYLTRANSFERASE1 (DGAT1) or PHOSPHOLIPID:DIACYLGLYCEROL ACYLTRANSFERASE (PDAT) on seed lipid comp

34 rol acyltransferase (DGAT), and phospholipid:diacylglycerol acyltransferase (PDAT), were strengthened

35 the absence of DGAT1 activity, phospholipid:diacylglycerol acyltransferase (PDAT1) plays an importan

36 accumulation, and co-expression of FUS3 and diacylglycerol acyltransferase 1 (DGAT1) further increas

37 Diacylglycerol acyltransferase 1 (DGAT1) is an integral

38 The ER-resident diacylglycerol acyltransferase 1 (DGAT1) selectively cha

39 ology of imidazopyridine-based inhibitors of diacylglycerol acyltransferase 2 (DGAT2) is described.

40 r triacylglycerols than controls but similar diacylglycerol acyltransferase activity, triacylglycerol

41 attributed to decreased expression of sn-1,2 diacylglycerol acyltransferase and mitochondrial acyl-Co

42 Acyl-CoA:diacylglycerol acyltransferase I (DGAT1) is a key enzyme

43 oexpressing RcLPCAT with castor phospholipid:diacylglycerol acyltransferase increased novel FA and to

44 lized the Arabidopsis (Arabidopsis thaliana) diacylglycerol acyltransferase mutant dgat1-1 (in which

45 The activity of Dga1p, a diacylglycerol acyltransferase, and TG accumulation were

46 ted by introducing a mutation in Arabidopsis diacylglycerol acyltransferase1 (AtDGAT1) in a line expr

47 d or decreased expression of ACYL-COENZYME A:DIACYLGLYCEROL ACYLTRANSFERASE1 (DGAT1) or PHOSPHOLIPID:

48 d primarily by the acyl-CoA-dependent enzyme diacylglycerol acyltransferase1 (DGAT1).

49 Since seedlings deficient in PHOSPHOLIPID:DIACYLGLYCEROL ACYLTRANSFERASE1 (PDAT1) were unable to a

50 e WRINKLED1 transcription factor, along with DIACYLGLYCEROL ACYLTRANSFERASE1 and the OLEOSIN1 oil bod

51 L37) or together with castor acyl:coenzyme A:diacylglycerol acyltransferase2 reduced HFA and total oi

52 Diacylglycerol acyltransferases (DGAT) 1 and 2 catalyse

53 hosphatidic acid acyltransferases (LPAT) and diacylglycerol acyltransferases (DGAT) that are required

54 ed in storage lipid biosynthesis, two type-1 diacylglycerol acyltransferases (DGAT1) from rice were c

55 Diacylglycerol acyltransferases (DGATs) catalyze a rate-

56 ipid phosphate phosphohydrolases (LPINs) and diacylglycerol acyltransferases (DGATs), are involved in

57 In the presence of a combination of diacylglycerol acyltransferases 1 and 2 (DGAT1 and DGAT2

58 , in vitro, and in vivo activities of type-2 diacylglycerol acyltransferases in Nannochloropsis ocean

59 the endoplasmic reticulum, and that certain diacylglycerol acyltransferases may be the candidate enz

60 We found that diacylglycerol acyltransferases, which catalyze the fina

61 d PKC, differences in Ca(2+) sensitivity and diacylglycerol affinity were excluded as mediators of th

62 Ala-PG and a novel alanylated lipid, Alanyl-diacylglycerol (Ala-DAG).

63 to the microbial antigen, alpha-glucuronosyl-diacylglycerol (alpha-GlcADAG) presented by CD1d, but no

64 phosphatidylcholines, triacylglycerols, and diacylglycerols, although lower ceramide concentrations,

65 The diacylglycerol analogue 1-oleoyl-2-acetyl-sn-glycerol (O

66 4,5-bisphosphate into the second messengers diacylglycerol and 1,4,5-inositol trisphosphate.

67 ty by decreasing 40% of triglyceride, 30% of diacylglycerol and 50% of PKC level in the heart, as wel

68 ion and generation of the second messengers, diacylglycerol and inositol-1,4,5-trisphosphate.

69 is the reaction between cytidine diphosphate-diacylglycerol and inositol-phosphate to yield phosphati

70 domain represents the recognition module for diacylglycerol and phorbol esters in protein kinase C, R

71 r regulator that controls the switch between diacylglycerol and phosphatidic acid signaling pathways.

72 sphatidylserine (PS) is synthesized from CDP-diacylglycerol and serine, a route that is different fro

73 ) and PI4P, as well as phosphatidic acid and diacylglycerol and used them to monitor lipid distributi

74 holipids with monoglucosyl- and glucuronosyl-diacylglycerols and by synthesizing new ornithine lipids

75 L), which catalyzes the hydrolysis of TGs to diacylglycerols and free fatty acids.

76 mic analysis revealed significant changes in diacylglycerols and phospholipids, suggesting that incre

77 glyceride; however, bioactive lipids such as diacylglycerols and sphingolipids are now thought to pla

78 /=1 diet compared with the others, including diacylglycerols and triacylglycerols, branched-chain ami

79 detected were phenolic compounds, ceramides, diacylglycerols and triacylglycerols.

80 on of lipotoxic intermediates (ceramides and diacylglycerols) and reduced reactive oxygen species pro

81 atidylcholine formation from CDP-choline and diacylglycerol, and full activity required divalent mang

82 cted curvature-inducing lipids (cardiolipin, diacylglycerol, and lyso-phosphatidylcholine) can modula

83 ipid signaling molecules 1-monoacylglycerol, diacylglycerol, and malonyl-CoA; the predominance of KAT

84 ing of completely saturated triacylglycerol, diacylglycerol, and monoacylglycerol with palmitate and

85 polar head group of the plant sulfolipid SQ-diacylglycerol, and SQ comprises a major proportion of t

86 esterified fatty acids; and increased IMCLs, diacylglycerols, and ceramides.

87 of apoC-II, apoC-III, triacylglycerols, and diacylglycerols, and increased apoA-I, apoA-II, and apoM

88 distinct specificities toward acyl CoAs and diacylglycerols, and may work in concert spatially and t

89 sferases, transmembrane enzymes that use CDP-diacylglycerol as donor substrate for this reaction, and

90 imaerin isoforms have a C1 domain that binds diacylglycerol as well as tumor-promoting phorbol esters

91 ephosphorylation of phosphatidate to produce diacylglycerol at the endoplasmic reticulum membrane, pl

92 A novel diacylglycerol-based galloyl structured lipid, 1,2-dipal

93 fects the partitioning of palmitate-enriched diacylglycerol between the phosphatidylcholine and triac

94 cient to explain differential recruitment of diacylglycerol binding proteins and, thus, differing dow

95 lphostin C, a PKC inhibitor that targets the diacylglycerol-binding site of the kinase.

96 pid metabolism involving triacylglycerol and diacylglycerol biosynthesis suggested activated lipid st

97 e catalyzes PA dephosphorylation to generate diacylglycerol; both substrate and product are key inter

98 s of triacylglycerol (i.e. the production of diacylglycerol by dephosphorylation of phosphatidate).

99 d from the membrane when PA is hydrolyzed to diacylglycerol by the PA phosphatase Pah1.

100 on of the protein kinase C-activating lipid, diacylglycerol, cAMP/Epac signaling blocks the bottlenec

101 y the acyl-CoA-dependent acylation of sn-1,2-diacylglycerol catalyzed by diacylglycerol acyltransfera

102 ot synthesize PE by the cytidine diphosphate diacylglycerol (CDP-DAG) pathway, is avirulent in the mo

103 E0021 (herein designated cpt) encoding a 1,2-diacylglycerol choline phosphotransferase homologous to

104 e cytidylyltransferase activities with a 1,2-diacylglycerol choline phosphotransferase that is common

105 AtROD1 encodes phosphatidylcholine:diacylglycerol cholinephosphotransferase (PDCT), the enz

106 lina sativa) of a lychee PHOSPHATIDYLCHOLINE:DIACYLGLYCEROL CHOLINEPHOSPHOTRANSFERASE (PDCT), which e

107 petition and knocked out phosphatidylcholine:diacylglycerol cholinephosphotransferase activity to pro

108 he acyl-editing enzymes phosphatidylcholine: diacylglycerol cholinephosphotransferase, and lysophosph

109 eate (PGPR), citric acid esters of mono- and diacylglycerols (CITREM) and ammonium phosphatides (AP).

110 ostasis observed in E-Syts KO cells, delayed diacylglycerol clearance from the PM and impaired Ca(2+)

111 n myocardial free fatty acids, ceramides and diacylglycerols, consistent with development of underlyi

112 in hepatic triglyceride (44%, P < 0.05) and diacylglycerol content (60%, P < 0.01) but a 30% increas

113 sistance was associated with increased C18:1-diacylglycerol content and protein kinase Cepsilon trans

114 istance could be attributed to reductions in diacylglycerol content and reduced PKC-epsilon and PKC-t

115 on and reduction of hepatic triglyceride and diacylglycerol content in livers of diet-induced obese a

116 ized lipase from Rhizomucormiehei, a maximum diacylglycerol content of 23% was obtained, after optimi

117 amyocellular triglyceride, sphingolipid, and diacylglycerol content were measured in vastus lateralis

118 and decreased ectopic lipid (triacylglycerol/diacylglycerol) content in liver and muscle.

119 otility, and transcription) are placed under diacylglycerol control by the distinctive substrate spec

120 Moreover, diacylglycerol (DAG) acts after PA in late fission, with

121 abolic network containing multiple different diacylglycerol (DAG) and acyl donor substrate pools.

122 eing one of them based on the fact that both diacylglycerol (DAG) and free fatty acids are not interd

123 In muscle, diacylglycerol (DAG) and intramyocellular triacylglycero

124 ation, which generates the second messengers diacylglycerol (DAG) and IP3 and ultimately results in m

125 ipidomic analysis shows a marked increase of diacylglycerol (DAG) and phosphatidic acid, the precurso

126 branes containing the lipid second messenger diacylglycerol (DAG) and subsequent phosphorylation of i

127 binding site for the lipid second messenger diacylglycerol (DAG) and the phorbol ester tumor promote

128 ggest that the PKC isoform involved requires diacylglycerol (DAG) but is Ca(2+) -insensitive, which a

129 ulation of hepatic triacylglycerol (TAG) and diacylglycerol (DAG) content was significantly attenuate

130 both liver and muscle triglyceride (TAG) and diacylglycerol (DAG) content, which was associated with

131 It is converted to substrate diacylglycerol (DAG) for MGDG Synthase (MGD1) which adds

132 Phosphatidic acid (PA) and diacylglycerol (DAG) have been found previously to be re

133 tes, RasGRP1 is recruited to the membrane by diacylglycerol (DAG) in a phospholipase C-gamma (PLCgamm

134 to all other TRPC channels, the PLC product diacylglycerol (DAG) is not sufficient for channel activ

135 In this study, we demonstrate that loss of diacylglycerol (DAG) kinase (Dgk) zeta, an enzyme which

136 In the yeast Saccharomyces cerevisiae, Dgk1 diacylglycerol (DAG) kinase catalyzes the CTP-dependent

137 Here, we report that targeting diacylglycerol (DAG) kinase zeta (DGKzeta), a negative r

138 rtmannin's effects not being due to reducing diacylglycerol (DAG) or IP3 availability, i.e. PIP2 modu

139 defined by seipin (Fld1), and a regulator of diacylglycerol (DAG) production, Nem1.

140 acylation of both monoacylglycerol (MAG) and diacylglycerol (DAG) to generate DAG and TAG, respective

141 Diacylglycerol kinase (DGK) phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA),

142 reted by WT hepatocytes contained 69% PL, 9% diacylglycerol (DAG), and 23% triacylglycerol (TAG) with

143 Instead, pharmacological manipulation of diacylglycerol (DAG), and protein kinase D (PKD) activit

144 lcholine (PC), the site of CPA biosynthesis, diacylglycerol (DAG), and TAG.

145 As TAG is produced from diacylglycerol (DAG), successful engineering strategies

146 Diacylglycerol (DAG), the lipid product of PLC that acti

147 Diacylglycerol (DAG), the product of the PLC-catalyzed P

148 Diacylglycerol (DAG), which is also increased in muscle

149 sphate pathway of triacylglycerol synthesis: diacylglycerol (DAG), which may cause insulin resistance

150 Ca(2+)- and diacylglycerol (DAG)-activated protein kinase C (cPKC) p

151 orms is associated with their Ca(2+)- and/or diacylglycerol (DAG)-dependent translocation to the plas

152 Diacylglycerol (DAG)-induced activation of phosphatidyli

153 oduction of inositol 1,4,5-trisphosphate and diacylglycerol (DAG).

154 n of the intramyocellular lipid-intermediate diacylglycerol (DAG).

155 Diacylglycerol (DAG)/phorbol ester-regulated protein kin

156 Presynaptic activation of the diacylglycerol (DAG)/protein kinase C (PKC) pathway is a

157 ority of these lipid species belonged to the diacylglycerol (DAG, 17 species) and triacylglycerol (TA

158 muscle accumulation of triglycerides, toxic diacylglycerols (DAG) and ceramides or suppress muscle P

159 The aim of this work was to produce diacylglycerols (DAG) and monoacylglycerols (MAG) with a

160 preparation of a nutritionally enriched 1,3-diacylglycerol(DAG)-rich oil from a blend of refined sun

161 into oligogalactolipids, acylated MGDGs, and diacylglycerols (DAGs), the direct precursor of TAGs, wa

162 Unlike diacetyl tartaric esters of mono- and diacylglycerols (DATEM, used as control), lipase use did

163 mmon isomeric glycerophosphocholine (PC) and diacylglycerol (DG) lipid species from human plasma.

164 kinase C activation as a result of increased diacylglycerol (DG) production in diabetic hyperglycaemi

165 oxidized phosphatidylcholine (PC/Ox-PC), and diacylglycerol (DG) species within implantation sites of

166 isplayed DGAT activity with 10:0-CoA and the diacylglycerol didecanoyl, that was approximately 4-fold

167 e activity to promote the flux of newly made diacylglycerol directly into TAG.

168 drolase (PAP) required for the generation of diacylglycerol during glycerolipid synthesis, and exhibi

169 Conical lipids, phosphatidylethanolamine and diacylglycerol, enhanced transporter activity up to 3-fo

170 However, the diacylglycerol enrichment was not accomplished in the sa

171 ive intrinsic curvature lipids (cardiolipin, diacylglycerol) facilitating fusion.

172 1, a phosphatidate phosphatase that produces diacylglycerol for triacylglycerol synthesis at the expe

173 affect the time course of alpha1B-AR-induced diacylglycerol formation, excluding a contribution of PK

174 t significant changes in their levels in the diacylglycerol fraction, suggesting that erucic acid was

175 ated into four fractions: polar lipids (PL), diacylglycerols, free fatty acids and triacylglycerols (

176 idate (PA) phosphatase Pah1, which generates diacylglycerol from PA, targets a nuclear membrane subdo

177 y, phosphatidic acid (PtdOH), generated from diacylglycerol in the PM, has to reach the ER for PtdIns

178 omoted fatty acid incorporation into TGs and diacylglycerols in both wild-type and ATGL-deficient hep

179 study deals with the enzymatic synthesis of diacylglycerols in rapeseed oil by the esterification of

180 re the main contributors to the acylation of diacylglycerols in the synthesis of triacylglycerol.

181 PI(4,5)P2, phosphatidylinositol 4-phosphate, diacylglycerol, inositol 1,4,5-trisphosphate, and Ca(2+)

182 We found here that inhibition of diacylglycerol kinase (DAGK) enzymes reduces desensitiza

183 Diacylglycerol kinase (DGK) activity was important for t

184 Diacylglycerol kinase (DGK) converts DG into phosphatidi

185 Diacylglycerol kinase (DGK) phosphorylates diacylglycero

186 Diacylglycerol kinase (DGK) produces PA by phosphorylati

187 Inhibition of diacylglycerol kinase (DGK), an enzyme of the phosphoino

188 udy, we demonstrate that genetic deletion of diacylglycerol kinase (DGK)zeta, a negative regulator of

189 (beta2AR), the peptide transporter (PepTSt), diacylglycerol kinase (DgkA), the alginate transporter (

190 so applied to the integral membrane protein, diacylglycerol kinase A where the structures determined

191 2019;4:420-428) identify a parasite-secreted diacylglycerol kinase as a key upstream activator of sig

192 complement defect, some have either impaired diacylglycerol kinase epsilon (DGKepsilon) activity, cob

193 Diacylglycerol kinase epsilon (DGKepsilon) is a membrane

194 P is mostly associated with one unique mRNA: diacylglycerol kinase kappa (Dgkkappa), a master regulat

195 es arachidonic acid via phospholipase D2 and diacylglycerol kinase rather than phospholipase A2.

196 -reactive T cells deficient in the regulator diacylglycerol kinase zeta (DGKzeta) with or without PD-

197 genetic ablation of a negative regulator of diacylglycerol kinase zeta increased the suppressive abi

198 In this pathway, RHO-1 inhibits diacylglycerol kinase, resulting in an increase in diacy

199 Loss of the DGK1-encoded diacylglycerol kinase, which converts diacylglycerol to

200 cases; however, mutations in the non-C gene diacylglycerol kinase-epsilon have been described recent

201 iana mutants impaired in the pollen-specific DIACYLGLYCEROL KINASE4 (DGK4) grow slower and become par

202 lecule, three bryostatin analogues bearing a diacylglycerol lactone-based C-ring, which possessed the

203 s), type 1 cannabinoid receptors (CB1Rs) and diacylglycerol lipase (DAGL) in the VTA.

204 tidylethanolaminephospholipase D (NAPE-PLD), diacylglycerol lipase (DAGL), or phospholipase C (PLC),

205 Diacylglycerol lipase (DAGL)-alpha and -beta are enzymes

206 eaving group of triazole urea derivatives as diacylglycerol lipase (DAGL)-alpha inhibitors.

207 to selectively inhibit 2-AG biosynthesis by diacylglycerol lipase (DAGL).

208 cerol, suggesting that SMc01003 also acts as diacylglycerol lipase (DglA) in its native background.

209 s the role of the main 2-AG producing enzyme diacylglycerol lipase alpha (DAGL-alpha).

210 cy by deleting its primary synthetic enzyme, diacylglycerol lipase alpha (DGLalpha), from dopamine D1

211 hosphoinositide-specific phospholipase C and diacylglycerol lipase alpha is known, alternative pathwa

212 d proteins involved in eCB signaling such as diacylglycerol lipase alpha, N-acyl-phosphatidylethanola

213 d by inhibiting the 2-AG-synthesizing enzyme diacylglycerol lipase alpha.

214 d 2-arachidonylglycerol 1) is synthesized by diacylglycerol lipase in pyramidal neurons; 2) travels r

215 mediated by 2-AG since it was blocked by the diacylglycerol lipase inhibitor DO34.

216 of either the CB1R antagonist, AM251, or the diacylglycerol lipase inhibitor, DO34.

217 bition of the major 2-AG synthesizing enzyme diacylglycerol lipase or blockade of CB1 receptors aboli

218 etic deletion or pharmacologic inhibition of diacylglycerol lipase-alpha (DAGL-alpha) impairs hippoca

219 Diacylglycerol lipase-alpha (DAGL-alpha), the principal

220 f endocannabinoid (eCB) biosynthetic enzymes diacylglycerol lipase-alpha (DAGLalpha) and -beta (DAGLb

221 , which is co-localized presynaptically with diacylglycerol lipase.

222 Diacylglycerol lipases (DAGLalpha and DAGLbeta) convert

223 t as selective and CNS-active inhibitors for diacylglycerol lipases (DAGLs), enzymes responsible for

224 potential, ADP, Ca(2+), 1-monoacylglycerol, diacylglycerol, malonyl-CoA, and HMG-CoA.

225 NAFLD to hepatic insulin resistance involves diacylglycerol-mediated (DAG-mediated) activation of pro

226 Conversely, enhancement of diacylglycerol-mediated signaling downstream of PLCgamma

227 ol kinase (DGK)zeta, a negative regulator of diacylglycerol-mediated signaling, has the desired effec

228 Restoration of diacylglycerol-mediated signalling in lipin1 deficient m

229 rapid conversion of plastidic monogalactosyl diacylglycerols (MGDGs) into oligogalactolipids, acylate

230 Activation of protein kinase C (PKC) by the diacylglycerol mimic phorbol-myristic acid resulted in s

231 -containing lipids including monomeromycolyl diacylglycerol (MMDAG), mycolate wax ester (MWE), and lo

232 Tandem mass spectrometry revealed a diacylglycerol modification at the cysteine residue in p

233 Evidence of differential trafficking of diacylglycerol moieties from the ER to chloroplast was u

234 eins are triacylated with a thioether-linked diacylglycerol moiety and an N-acyl chain.

235 ansfers the sn-2 ester-linked lipid from the diacylglycerol moiety to the alpha-amino terminus withou

236 14 closely associated with fat content, the Diacylglycerol O-Acyltransferase 1 (DGAT1) gene turned o

237 Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes t

238 xpression of placental FA synthase (FAS) and diacylglycerol O-acyltransferase 1 (DGAT1) was negativel

239 readily form LD largely via the enzyme DGAT (diacylglycerol O-acyltransferase 1) and degrade LD via A

240 essed high levels of mRNA for Dgat1 encoding diacylglycerol-O-acyltransferase-1 (DGAT1), an enzyme th

241 dylcholine and phosphatidylinositol (but not diacylglycerol or sphingomyelin) are significantly eleva

242 e there changes in skeletal muscle ceramide, diacylglycerol, or amino acid metabolite levels.

243 sm in Gnb5(-/-) MIN6 cells showed that cAMP, diacylglycerol, or Ca(2+) levels were not significantly

244 s of Ca(2+) entry and ionic currents through diacylglycerol- or receptor-activated recombinant TRPC6

245 change in the concentration of either total diacylglycerol (P = 0.123) or total ceramides (P = 0.150

246 or through activation of the phospholipase-C-diacylglycerol pathway share characteristic properties w

247 synthesis of major phospholipids via the CDP-diacylglycerol pathway.

248 These lipids include phosphoinositides, diacylglycerol, phosphatidic acid, and cholesterol/ergos

249 PC, PC-derived diacylglycerol, phosphatidic acid, and lyso-phosphatidyl

250 at C.sativa seeds have very high activity of diacylglycerol-phosphatidylcholine interconversion.

251 nst the development of hepatic steatosis and diacylglycerol-PKCepsilon-induced impairments in hepatic

252 dephosphorylation of phosphatidate to yield diacylglycerol, plays a crucial role in the synthesis of

253 sphoglycerol (POPG) and 1-palmitoyl-2-oleoyl diacylglycerol (PODAG) stimulate the IMD pathway of tick

254 (arachidonic acid), but increases of a 2-AG diacylglycerol precursor in hippocampus, PFC, striatum,

255 ugh TRPC3/C6/C7 can be directly activated by diacylglycerols produced by PLC breakdown of phosphatidy

256 ation, and reaction temperature on mono- and diacylglycerol production and I(t) are all assessed.

257 sitol 4,5-bisphosphate (PIP2) depletion, and diacylglycerol production.

258 Using the example of diacylglycerols, prominent second messengers, we here in

259 were able to determine binding constants for diacylglycerol-protein interactions, and kinetic paramet

260 phate substrates, including PA, lyso-PA, and diacylglycerol pyrophosphate.

261 t not that of LPA2 or inhibition of LPA3, by diacylglycerol pyrophosphate.

262 riants in RASGRP2, which encodes calcium and diacylglycerol-regulated guanine exchange factor I (CalD

263 ng a content of 24.8% and 51.9% of mono- and diacylglycerols, respectively, over an I(t) of 1.41 h.

264 the fatty-acyl profile of phospholipids and diacylglycerol revealed that chronic stressed rats had h

265 elective preparation of sn-1 mono and sn-1,3 diacylglycerols rich in CLA, with a ratio of sn-1,3/sn-1

266 The production of mono- and diacylglycerols rich in polyunsaturated fatty acids is a

267 kinetics vary by orders of magnitude due to diacylglycerol side-chain composition.

268 or similar hydrolysis (free fatty acids and diacylglycerols), similar primary (K(232), oxidized-tria

269 , which allow acute manipulation of distinct diacylglycerol species in the plasma membrane.

270 amounts of phospholipids, lysophospholipids, diacylglycerols, sterols, and sulfolipids.

271 d for native TRPC6-like [Ca(2+)]i signals in diacylglycerol-stimulated rat pulmonary artery smooth mu

272 insensitive to desensitization by sustained diacylglycerol stimulation.

273 utant of S. meliloti transiently accumulates diacylglycerol, suggesting that SMc01003 also acts as di

274 cells in vitro, we show ECs deficient in CDP-diacylglycerol synthase 2 are uniquely sensitive to incr

275 study revealed the potential of an enzymatic diacylglycerol synthesis in edible oils as a suitable al

276 ers form approximately 2-5 times faster from diacylglycerols than from monoacylglycerols.

277 phospholipids and galactolipids to generate diacylglycerol that can be phosphorylated to phosphatidi

278 binds to protein kinase C competitively with diacylglycerol, the endogenous protein kinase C regulato

279 sphatidate dephosphorylation, which produces diacylglycerol, the enzyme plays a major role in the syn

280 wed acyltransferase activity with phytol and diacylglycerol, thus producing phytyl esters and triacyl

281 ium salmoninarum, with and without bound CDP-diacylglycerol to 3.6 and 2.5 A resolution, respectively

282 ignal sequence and catalyzes the addition of diacylglycerol to an invariant cysteine.

283 roup from acetyl-CoA to the sn-3 position of diacylglycerol to form 3-acetyl-1,2-diacyl-sn-glycerol (

284 talyzes the ATP-dependent phosphorylation of diacylglycerol to form phosphatidic acid (PA) in the pho

285 Here we show that SMc01003 converts diacylglycerol to monoacylglycerol and a fatty acid, and

286 ncoded diacylglycerol kinase, which converts diacylglycerol to phosphatidate, partially suppressed th

287 osphatidic acid phosphatases (PAPs) generate diacylglycerol to regulate triglyceride synthesis and ce

288 rol lipases (DAGLalpha and DAGLbeta) convert diacylglycerol to the endocannabinoid 2-arachidonoylglyc

289 ein interactions, and kinetic parameters for diacylglycerol transbilayer movement and turnover in qua

290 pids predominantly belonged to the groups of diacylglycerols, triacylglycerols and ceramides.

291 ign for the signaling lipids sphingosine and diacylglycerol; uncaging of the probe for these two spec

292 Binding activity for diacylglycerol was restored in parallel.

293 When diacylglycerol was used as the substrate, CrDGTT1 prefer

294 became stronger an increase of oxylipins and diacylglycerols was revealed.

295 s, sterols, triterpene dialcohols, waxes and diacylglycerols) were found for olives at medium-early r

296 erol (OAG), the membrane-permeable analog of diacylglycerol, were not defined.

297 PIP(2) into inositol 1,4,5-trisphosphate and diacylglycerol, which are well known to modulate vascula

298 not regulated by the lipid second messenger diacylglycerol, which has led to speculation about wheth

299 that mechanically activated AT1 R generates diacylglycerol, which in turn activates PKC which induce

300 mitant with an increase of some digalactosyl diacylglycerols, which are part of the chromoplasts lipi