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1 lycan-derived muropeptides that contain meso-diaminopimelic acid.
2 rectly convert tetrahydrodipicolinate to L,L-diaminopimelic acid.
3 mosome to impose an obligate requirement for diaminopimelic acid.
4 r the bacterial synthesis of lysine and meso-diaminopimelic acid.
5 , and 42% had peptide side chains containing diaminopimelic acid, 29% of which was involved in cross-
6 es are probably involved in the synthesis of diaminopimelic acid (a component of peptidoglycan), main
7 tinal bacteria bearing gamma-d-glutamyl-meso-diaminopimelic acid, a ligand for the intracellular pept
8 s cell wall, yet only loses ~0 to 5% of meso-diaminopimelic acid, a PG-specific amino acid, per gener
9 ctrometry) analysis of the unique amino acid diaminopimelic acid (after derivatization with isopropyl
10                                              Diaminopimelic acid, also formed by this enzymatic pathw
11 ntained primarily DD-crosslinks between meso-diaminopimelic acid and D-alanine residues, whereas stal
12 The dapE operon enzymes synthesize both meso-diaminopimelic acid and lysine and, therefore, represent
13 NOD1 and NOD2 ligands (gamma-d-glutamyl-meso-diaminopimelic acid and muramyl dipeptide, respectively)
14 e bacterial components gamma-d-glutamyl-meso-diaminopimelic acid and muramyl dipeptide, respectively.
15                     Mutants also retain more diaminopimelic acid and N-acetylmuramic acid during germ
16 ts N-succinyl-L,L-diaminopimelic acid to L,L-diaminopimelic acid and succinate.
17  amidation at the alpha-(l)-carboxyl of meso-diaminopimelic acid and the presence of muropeptides cro
18  the iE-DAP dipeptide [gamma-d-glutamyl-meso-diaminopimelic acid]) and the S Typhimurium effector pro
19 ctodomains together and the critical role of diaminopimelic acid as the specificity determinant for P
20 sulting in defective cell wall synthesis and diaminopimelic acid auxotrophy.
21 aA, i.e., hydrolysis of the gamma-D-glutamyl-diaminopimelic acid bond in the murein tripeptide L-alan
22 ypes of peptidoglycan cross-links using meso-diaminopimelic acid both as a donor and an acceptor, als
23                 Hydrolysis of N-succinyl-L,L-diaminopimelic acid by the dapE-encoded desuccinylase is
24                              NOD1 recognizes diaminopimelic acid-containing dipeptide or tripeptide m
25   Nod1, a cytosolic protein that senses meso-diaminopimelic acid-containing ligands derived from pept
26                                              Diaminopimelic acid-containing peptidoglycan, produced b
27 ved LPXTG motif and the amino group of the m-diaminopimelic acid crossbridge within the listerial pep
28 , UDP-N-acetylmuramyl-L-Ala-gamma-D-Glu-meso-diaminopimelic acid-D-Ala-D-Ala (UDP-MurNAc-pentapeptide
29 y N-acetylmuramyl-L-alanine-D-glutamate-meso-diaminopimelic acid-D-alanyl-D-alanine, whereas those is
30 usly used to synthesize amino-differentiated diaminopimelic acid (DAP) and biologically active analog
31  asd, resulting in obligate requirements for diaminopimelic acid (DAP) and d-alanine for growth.
32 n to occur by way of a pathway that utilizes diaminopimelic acid (DAP) as a central intermediate, the
33                               We generated a diaminopimelic acid (DAP) auxotroph (AA400) of L. pneumo
34 ymes, such as DapF, which is capable of both diaminopimelic acid (DAP) epimerase and glutamate racema
35                             A variant of the diaminopimelic acid (DAP) pathway uses diaminopimelate a
36 tion by amidation of cell wall peptidoglycan diaminopimelic acid (DAP) residues.
37  lysine biosynthetic pathway converting meso-diaminopimelic acid (DAP) to l-lysine.
38  for its peptidoglycan, rather than meso-2,6-diaminopimelic acid (DAP) used by most Gram-negative bac
39                          It was found that a diaminopimelic acid (DAP)-containing muramyl tetrapeptid
40 itive (lysine-containing) and Gram-negative (diaminopimelic acid (DAP)-containing) bacteria to demons
41 wed that it was critical for the delivery of diaminopimelic acid (DAP)-muropeptides and activation of
42      Thirteen mono-N-acyl derivatives of 2,6-diaminopimelic acid (DAP)-new potential inhibitors of th
43                                 Mutants of a diaminopimelic acid (Dap)-requiring strain of Escherichi
44  bacterial infections through recognition of diaminopimelic acid (DAP)-type peptidoglycan and activat
45  and secreted/cytosolic PGRP-LE, which relay diaminopimelic acid (DAP)-type peptidoglycan sensing to
46 of the muramyl peptides was replaced by meso-diaminopimelic acid (DAP).
47            Here, we find that N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE) facilitates fun
48 ing sites in the dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE) from Haemophilu
49                               N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE) is a key enzyme
50 nhibitors of the dapE-encoded N-succinyl-l,l-diaminopimelic acid desuccinylase (DapE; EC 3.5.1.18)-we
51              The dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase functions in a late st
52        In E. coli, dapE encodes N-succinyl-L-diaminopimelic acid desuccinylase, which catalyzes the h
53 , whereas PGN of Bacillus subtilis with meso-diaminopimelic acid directly tethered with d-alanine is
54 -N-acetylmuramyl-l-alanyl-d-isoglutamyl-meso-diaminopimelic acid (GM-triDAP), human monocyte-derived
55 imulatory molecules is gamma-D-glutamyl-meso-diaminopimelic acid (iE-DAP), but the identity of the ma
56 its agonist, bacterial gamma-D-glutamyl-meso-diaminopimelic acid (iE-DAP), in term trophoblast cultur
57 imal component of bacterial cell walls, meso-diaminopimelic acid (iE-DAP).
58 tiates inflammation in response to bacterial diaminopimelic acid (iE-DAP).
59 y NOD1 is a dipeptide, gamma-D-glutamyl-meso-diaminopimelic acid (iE-DAP).
60              Biosynthesis of lysine and meso-diaminopimelic acid in bacteria provides essential compo
61 es forming a subsite to accommodate meso-2,6-diaminopimelic acid in both the DD-carboxypeptidase and
62 de or tripeptide side chains, and 11% of the diaminopimelic acid in these side chains was involved in
63 of transporting peptidoglycan fragments (tri-diaminopimelic acid) in E. coli and in C. trachomatis Th
64 able interactions with a third residue, meso-diaminopimelic acid, in the PG.
65  plasmid inhibits the incorporation of [(3)H]diaminopimelic acid into cell wall and leads to a profil
66 N-acetylmuramyl-Ala-gamma-Glu-A2pmAla (A2pm, diaminopimelic acid), is released by Bordetella pertussi
67 l L,L diaminopimelic acid (L,L-NSDAP) to L,L-diaminopimelic acid (L,L-DAP) and succinate.
68 llohydrolase which hydrolyses N-succinyl L,L diaminopimelic acid (L,L-NSDAP) to L,L-diaminopimelic ac
69 E was shown to only hydrolyze L,L-N-succinyl-diaminopimelic acid (L,L-SDAP) and was inactive toward D
70 sis of N-succinyl-L-diaminopimelic acid to L-diaminopimelic acid (L-DAP) and succinate.
71 , the enzyme immediately preceding it in the diaminopimelic acid/lysine biosynthetic pathway.
72                        The synthesis of meso-diaminopimelic acid (m-DAP) in bacteria is essential for
73 acetyl-d-muramyl-l-alanyl-d-isoglutamyl-meso-diaminopimelic acid [M-triDAP] and LPS, respectively).
74 ides consist of l-alanine, d-glutamate, meso-diaminopimelic acid (mDAP) and d-alanine (d-Ala) with cr
75 nspeptidation (meso-diaminopimelic acid-meso-diaminopimelic acid), mediated by LdtD.
76 inylase pathway for the biosynthesis of meso-diaminopimelic acid (meso-DAP) and L-lysine.
77        The stereoselective synthesis of meso-diaminopimelic acid (meso-DAP), the key cross-linking am
78 idoglycan had more LD-transpeptidation (meso-diaminopimelic acid-meso-diaminopimelic acid), mediated
79 ining protein-1 (Nod1, which recognizes meso-diaminopimelic acid (mesoDAP)-containing peptidoglycan f
80 etal-dependent, with a Km for N-succinyl-L,L-diaminopimelic acid of 1.3 mM and a turnover number of 2
81 he amidation of the e-carboxyl group of meso-diaminopimelic acid present in the PGN peptide chain is
82 et interact with the third position meso-2,6-diaminopimelic acid residue of the peptidoglycan stem pe
83 ation is the free carboxyl group of the meso-diaminopimelic acid residue.
84 sidues and direct cross-linkage between meso-diaminopimelic acid residues.
85 synthesis of orthogonally protected meso-2,6-diaminopimelic acid, starting from easily accessible chi
86 nzyme discriminates between L-lysine and D,L-diaminopimelic acid, the predominant amino acid that rep
87 p of the pathway and converts N-succinyl-L,L-diaminopimelic acid to L,L-diaminopimelic acid and succi
88 ich catalyzes the hydrolysis of N-succinyl-L-diaminopimelic acid to L-diaminopimelic acid (L-DAP) and
89 l dipeptide (MDP) and l-Ala-gamma-D-Glu-meso-diaminopimelic acid (Tri-DAP) into cells.
90  Drosophila, the Imd pathway is activated by diaminopimelic acid-type peptidoglycan and triggers the
91 rosophila immune response, bacterial derived diaminopimelic acid-type peptidoglycan binds the recepto
92 y mediate discrimination between lysine- and diaminopimelic acid-type PGNs.
93 he bacterial dipeptide gamma-d-glutamyl-meso-diaminopimelic acid was intact in MyD88 deficient mice b
94 etitive inhibitors of the substrate, but d,d-diaminopimelic acid was not.
95 in tripeptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelic acid, was demonstrated in the cell extrac
96 ptane-2,2'-dicarboxylic acid, an analogue of diaminopimelic acid, was prepared in racemic form and th
97                            Both L,L- and D,L-diaminopimelic acid were competitive inhibitors of the s
98  threonine and the side-chain amino group of diaminopimelic acid within the cell wall peptidoglycan o
99 mide-linked to the side chain amino group of diaminopimelic acid within the peptidoglycan peptide ste
100 mide linked to the side chain amino group of diaminopimelic acid within the wall peptides of B. anthr