ライフサイエンスコーパス: diapause

1 e in response to starvation (L1 arrest or L1 diapause).

2 oward sugar feeding and lipid sequestration (diapause).

3 female Cx. pipiens during the early phase of diapause.

4 in the intestinal epithelial cells at larval diapause.

5 ter a state of dormancy similar to embryonic diapause.

6 n important role in the modulation of larval diapause.

7 it remains unknown how ILPs modulate larval diapause.

8 here were nine identical pathways related to diapause.

9 cells lacking Mga are lost during embryonic diapause.

10 hysiological processes both before and after diapause.

11 ntriguing maternal effects that regulate egg diapause.

12 ASI neuron pair, to promote entry into dauer diapause.

13 ct species to prepare for winter by inducing diapause.

14 sa191), causes constitutive entry into dauer diapause.

15 e between reproductive development and dauer diapause.

16 gulate the response to starvation-induced L1 diapause.

17 l pests, DH prompts the termination of pupal diapause.

18 al of nematodes during starvation-induced L1 diapause.

19 DH antagonist that blocks the termination of diapause.

20 rvae that are environmentally programmed for diapause.

21 on of the timing of entry into and exit from diapause.

22 hat are much more active than DH in breaking diapause.

23 to enter diapause and how long to remain in diapause.

24 about the molecular modifications underlying diapause.

25 egulate longevity, stress response and dauer diapause.

26 icles were arrested in a stage comparable to diapause.

27 vely expressed ancestral life history trait: diapause.

28 rmone signaling, which is a prerequisite for diapause.

29 hromosomes and remain arrested throughout L1 diapause.

30 y, is not required for germline arrest in L1 diapause.

31 to take a blood meal upon the termination of diapause.

32 arrest, implying that CeTOR regulates dauer diapause.

33 of type-Ia(1) cells can impede induction of diapause.

34 t on the duration of the overwintering pupal diapause.

35 rvae on the photoperiodic induction of pupal diapause.

36 an important role in the induction of pupal diapause.

37 repression of metabolism and muscle genes in diapause.

38 lived, alternate organismal state, the dauer diapause.

39 an monarchs, yet they did enter reproductive diapause.

40 Late in diapause (2-3 months at 18 degrees C), the genes encodin

41 Diapause, a dominant feature in the life history of many

42 logical element that is necessary to trigger diapause, a gyne trait.

43 se environments, animals arrest at the dauer diapause, a long-lived stress resistant stage.

44 onse to protect embryos in utero by inducing diapause, a natural form of suspended animation.

45 The exception to this rule is embryonic diapause, a reversible state of suspended development tr

46 n synthesis inhibition, but in the course of diapause, a state of dormancy and increased stress toler

47 h the second larval stage, worms enter dauer diapause, a state of global and reversible developmental

48 es for vector persistence include dry-season diapause (aestivation) and long-distance migration (LDM)

49 cumnatal life history strategies, voltinism, diapause, aestivation, oviposition site, clutch size, an

50 at are stimulated by transient developmental diapause also underlie cryptic variation in the requirem

51 n, that confer on the larva diapause and non-diapause alternative developmental trajectories interact

52 vated by FOXO are highly up-regulated during diapause and are thus strong candidates for implementati

53 tanding of molecular events occurring during diapause and diapause termination in calanoid copepods.

54 trus, displaying a variable length embryonic diapause and exhibiting pseudopregnancy.

55 ot included in our experiments (e.g., during diapause and gonad maturation), and for contaminant tran

56 his information to regulate whether to enter diapause and how long to remain in diapause.

57 story traits, including entry into the dauer diapause and longevity.

58 or Rb critically promotes survival during L1 diapause and most likely does so by regulating the expre

59 and DAF-2/Insulin, that confer on the larva diapause and non-diapause alternative developmental traj

60 performed to examine the differences between diapause and non-diapause eggs at both transcriptional a

61 mpose large fitness costs on insects showing diapause and other life cycle responses, threatening pop

62 les in cryoprotection and storing energy for diapause and post-diapause stages.

63 tional profiles in C5s during termination of diapause and progression towards adulthood.

64 hronic acid (DA) promote bypass of the dauer diapause and proper gonadal migration during larval deve

65 gonad and germline development during dauer diapause and recovery, and our finding that PTEN acts no

66 a crucial role in the decision between dauer diapause and reproductive growth.

67 response (UPR) in promoting entry into dauer diapause and suggest that, in addition to cell-autonomou

68 ts from two different laboratory colonies (a diapausing and a non-diapausing colony) were sampled at

69 ces appear to exist between insects from non-diapausing and diapausing colonies while no significant

70 an Hsp70 cognate, Hsc70, is uninfluenced by diapause, and Hsp90 is actually down-regulated during di

71 Insects accumulate reserves prior to diapause, and metabolic depression during diapause promo

72 is maintained at key developmental genes in diapause, and the Polycomb member CBX7 mediates repressi

73 o Culex pipiens into its overwintering adult diapause, and these two critical signaling pathways appe

74 Fall migrants are in reproductive diapause, and they use a time-compensated sun compass to

75 ated with an altered genetic program in post-diapause animals, in combination with a novel ligand-ind

76 lations but differs between reproductive and diapausing animals.

77 ion of starvation-induced adult reproductive diapause (ARD) in Caenorhabditis elegans.

78 ogical processes and initiation mechanism of diapause are not well understood.

79 climate change, plastic responses involving diapause are often critical for population persistence,

80 tem when animals enter an insulin-controlled diapause arrest stage under harsh environmental conditio

81 portant rice pest in Asia enters facultative diapause as larvae.

82 r adults are thought to undergo reproductive diapause associated with the lack of available larval ho

83 e also discuss other possible candidates for diapause-associated nutrient regulation including adipok

84 g at the surface and the rest of the year in diapause at depth.

85 l state corresponding to the epiblast of the diapaused blastocyst and indicate that mTOR regulates de

86 ion, maintain a gene expression signature of diapaused blastocysts and remain pluripotent.

87 We show that both naturally diapaused blastocysts in vivo and paused blastocysts ex

88 Indeed, c-Myc is depleted in diapaused blastocysts, and the differential expression s

89 ecision to enter diapause or the duration of diapause, but it had a profound effect on the pupa's abi

90 not required for the animals' entry into L1 diapause, but plays a critical role in long-term surviva

91 ly grown, third-instar larvae programmed for diapause by a photoperiodic (short-day) signal were assa

92 atures, female Cx. pipiense prepares for the diapause by actively feeding on carbohydrates to increas

93 role of asm-3 in regulation of lifespan and diapause by modulating IIS pathway.

94 y period, the northern boundaries of modeled diapausing C. glacialis expanded poleward and the annual

95 n the tobacco hornworm, Manduca sexta, pupal diapause can be induced by exposure of fifth-instar larv

96 squito Culex pipiens to enter a reproductive diapause characterized by an arrest in ovarian developme

97 xist between insects from non-diapausing and diapausing colonies while no significant differences in

98 laboratory colonies (a diapausing and a non-diapausing colony) were sampled at each life stage to de

99 the rate of developmental progression during diapause contributes to the evolution of seasonality in

100 nals, the ascarosides, control developmental diapause (dauer), olfactory learning, and social behavio

101 one of two developmental fates (adulthood or diapause) depending on environmental conditions.

102 eed with reproductive development or undergo diapause depends on food abundance, population density,

103 Diapause-destined adult females and nondiapausing counte

104 The dsi-RNA injected diapause-destined female post-adult eclosion were fed fo

105 trypsin-like protease) are down-regulated in diapause-destined females, and that concurrently, a gene

106 e developmental divergence early and late in diapause development and an important role for hub genes

107 pupal diapause, dynamically regulated across diapause development, and differentially regulated after

108 ons of genes differentially expressed during diapause development.

109 ccession of eco-physiological phases termed "diapause development." The phasing is varied in the lite

110 ofile, we could readily distinguish distinct diapause developmental phases associated with induction/

111 y) signal were assayed as they traversed the diapause developmental program.

112 ctually down-regulated during diapause, thus diapause differs from common stress responses that elici

113 Regulation of embryonic diapause, dormancy that interrupts the tight connection

114 e seasons in a hormonally regulated state of diapause during which their activity ceases, development

115 thways differentially regulated during pupal diapause, dynamically regulated across diapause developm

116 allele frequency among individuals that end diapause early or late, with alleles maintained in high

117 In contrast, cysts formed during the diapause egg-resting stages of many metazoans share feat

118 e populations, and from residual, historical diapausing egg banks.

119 ine the differences between diapause and non-diapause eggs at both transcriptional and translational

120 addition, it reveals cellular metabolism in diapause eggs is more active than in non-diapause eggs,

121 re important role, but only highly resistant diapause eggs of killifish have been found to survive pa

122 in diapause eggs is more active than in non-diapause eggs, and up-regulated enzymes may play roles i

123 scriptional and metabolite profiles of mouse diapause embryos and identify unique gene expression and

124 Analysis of embryonic stem cells and diapaused embryos reveals near-complete conservation of

125 Diapausing embryos in utero require san-1 to survive, in

126 , the stress-tolerant physiological state of diapause enables coping with seasonal challenges [1, 12-

127 ential expression signatures of dKO ESCs and diapaused epiblasts are remarkably similar.

128 ork and transcriptome signatures akin to the diapaused epiblasts in vivo.

129 lead to temporary developmental quiescence (diapause), exemplified by the dauer larva stage of the n

130 dependently confirmed this ability to impact diapause expression through genetic complementation mapp

131 ts are functionally distinct with respect to diapause expression, and the polymorphism also shows geo

132 We show that two signatures of diapause (extended maturation time and enhanced synthesi

133 tant exits L1 arrest and IIS-dependent dauer diapause faster than control worms, but is not involved

134 As the females then enter diapause, fatty acid synthase is only sporadically expre

135 bition of long-term carbon energy storage in diapausing females.

136 Thus, combined with embryonic diapause, females are continuously pregnant and lactatin

137 We propose the definition of "metabolic diapause" for the changes induced by Foxo1 to protect be

138 indicated that the ancestral state was a non-diapausing forest species, and that habitat preference a

139 Diapause furthermore activates expression of glutamine t

140 C. elegans diapause, gonadal outgrowth, and life span are regulated

141 The study of hormonal regulation of mosquito diapause has focused primarily on adult diapause, with l

142 e genetic basis for environmental control of diapause has wider implications for evolutionary respons

143 diapause in moths is the 24-aa neuropeptide, diapause hormone (DH).

144 atory peptide 2b (CAPA); CAPAr, 2) pyrokinin/diapause hormone (PK1/DH); PKr-A, -B, 3) pyrokinin/phero

145 risk-spreading, particularly in facultative diapause, I have been unable to find any definitive test

146 rates of C. glacialis individuals attaining diapause in a circumpolar transition zone increased subs

147 erlying evolutionary genetic architecture of diapause in any organism.

148 Here we demonstrate embryonic diapause in C. elegans, and show that this diapause prot

149 G protein signaling pathways control meiotic diapause in C. elegans, highlighting contrasts and paral

150 e of multiple environmental cues in inducing diapause in C. finmarchicus.

151 mate finding, aggregation, and developmental diapause in Caenorhabditis elegans, but it is unknown wh

152 regulator of longevity, metabolism and dauer diapause in Caenorhabditis elegans.

153 ified by the diverse developmental stages of diapause in closely related species.

154 ole of the circadian clock in the control of diapause in Drosophila and other insects.

155 We examine the genetic control of diapause in insects and show how the failure to recogniz

156 Low temperature induces diapause in locusts.

157 One of the hormones that regulates diapause in moths is the 24-aa neuropeptide, diapause ho

158 of the timeless gene affect the incidence of diapause in response to changes in light and temperature

159 ifferences in the rate of development during diapause in Rhagoletis pomonella, a fly specialized to f

160 p-regulation of Hsps appears to be common to diapause in species representing diverse insect orders i

161 ARD differs from the C. elegans dauer diapause in that it enables sexually mature adults to de

162 as two savannah species undergo reproductive diapause in the dry season, either with or without pre-d

163 st plant drove more rapid development during diapause in the early fly population.

164 omics tools to identify molecules linked to diapause in the locust.

165 ic variation in the photoperiodic control of diapause in the pitcher-plant mosquito Wyeomyia smithii

166 one, an endocrine trigger known to terminate diapause in this species.

167 ey characteristic of overwintering dormancy (diapause) in the mosquito Culex pipiens is the switch in

168 ad to the induction of developmental arrest (diapause) in their progeny, allowing winter survival of

169 osely mirrors the known latitudinal cline in diapause incidence.

170 The most up-regulated genes in diapause include Polycomb complex members.

171 Up-regulated genes related to diapause included glutathiones-S-transferase et al., and

172 thin and among populations; the incidence of diapause increases with more temperate climates and has

173 Here, we report that diapause-inducing pheromones correct heterochronic devel

174 Diapausing insects pass through a stereotypic succession

175 Diapause is a complex and dynamic process.

176 Diapause is a complex phenotype, and FOXO emerges as a p

177 Nutrient utilization during diapause is a dynamic process, and insects appear capabl

178 us propose that up-regulation of Hsps during diapause is a major factor contributing to cold-hardines

179 Diapause is a physiological reproductive strategy widely

180 Diapause is a state of suspended development that helps

181 Thus, vertebrate diapause is a state of suspended life that is actively m

182 Diapause is a widespread adaptation to seasonality acros

183 Transcriptome analyses indicate that diapause is an active state, with dynamic regulation of

184 dictates the O(2) tension at which embryonic diapause is engaged.

185 quiescence of germline development during L1 diapause is not a passive consequence of nutrient depriv

186 Diapause is the classic adaptation to seasonality in art

187 The dormant state known as diapause is widely exploited by insects to circumvent wi

188 y of INS-35 and INS-7, which suppress larval diapause, is changed in the intestinal epithelial cells

189 iapause: photoperiodism, hormonal events and diapause itself.

190 e environmental conditions induce a state of diapause known as dauer by inhibiting the conserved DAF-

191 Occasional necrotic diapause larvae were observed which displayed intense sy

192 The symbiont was also visualized in diapause larvae.

193 colytic and epigenetically H4K16Ac-negative, diapause-like state.

194 ionally required for muscle preservation and diapause maintenance.

195 n the dry season, either with or without pre-diapause mating.

196 As diapause may be controlled by lipid accumulation, our fi

197 e, indicating that hypoxia-induced embryonic diapause may be mechanistically related to suspended ani

198 egulated by amino acid levels, is causal for diapause metabolism and epigenetic state.

199 s evidence for risk-spreading in facultative diapause, migration polyphenism, spatial distribution of

200 drates on glycogen and lipid biosynthesis in diapausing mosquitoes was investigated in vivo using 13C

201 e and glucose are metabolized differently in diapausing mosquitoes.

202 Molecular mechanisms involved in diapause nutrient regulation remain poorly known, but in

203 "L1 arrest" (also known as "L1 diapause") occurs without morphological modification but

204 Delayed implantation (embryonic diapause) occurs when the embryo at the blastocyst stage

205 enger that is positively correlated with the diapause of C. suppressalis.

206 ity of this response to that observed in the diapause of Drosophila melanogaster and in dauer formati

207 S. crassipalpis with the adult reproductive diapause of Drosophila melanogaster and the larval dauer

208 rchived expression data to compare the pupal diapause of S. crassipalpis with the adult reproductive

209 The adult diapause of the linden bug, Pyrrhocoris apterus, involve

210 Elevated water temperature prolonged summer diapause of the mayfly and shifted its life cycle to the

211 To understand the molecular basis of diapause, 'omics' analyses were performed to examine the

212 ing RNAi did not alter the decision to enter diapause or the duration of diapause, but it had a profo

213 ttle current information available on larval diapause or the intriguing maternal effects that regulat

214 inent role in developmental recovery from L1 diapause partly through repressing the expression of cer

215 rves must be sequestered to both survive the diapause period and enable postdiapause development that

216 s indicate that VdCmr1 mediates entry to the diapause period in V. dahliae in response to HT and cont

217 egulation of the Hsps begins at the onset of diapause, persists throughout the overwintering period,

218 he physiological relevance of the concept of diapause phasing.

219 o (cpo) as a major genetic locus determining diapause phenotype in D. melanogaster and independently

220 h linkage association that variation for the diapause phenotype is caused by a single Lys/Ile substit

221 rse physiological pathways that generate the diapause phenotype.

222 the complex suite of genes that subserve the diapause phenotype.

223 of the downstream gene FOXO, leading to the diapause phenotype.

224 ng functionally related genes - that lead to diapause: photoperiodism, hormonal events and diapause i

225 f genes associated with lipid metabolism and diapause preparation in C. finmarchicus.

226 The copepods showed no clear signs of diapause preparation, supporting earlier observations of

227 ifish (Nothobranchius furzeri), we show that diapause preserves complex organisms for extremely long

228 n-type cryptochrome 2 gene that promotes the diapause program.

229 ent the early steps linked to termination of diapause programming.

230 to diapause, and metabolic depression during diapause promotes reserve conservation.

231 c diapause in C. elegans, and show that this diapause protects embryos from otherwise lethal hypoxia.

232 How diapause protects living organisms is largely unknown.

233 , and control-operated larvae developed into diapausing pupae.

234 was injected into mosquitoes programmed for diapause (reared under short day lengths) fat storage wa

235 l signaling pathways considered critical for diapause regulation.

236 In a previous evolution experiment, diapause-related traits changed rapidly in response to t

237 t gut, the decision between reproduction and diapause relies on an interaction between JH signaling a

238 an nuclear receptor, DAF-12, regulates dauer diapause, reproductive development, fat metabolism, and

239 t state by the inhibition of MYC, resembling diapause, requires the presence of the RB family protein

240 How the diapause response can be molded evolutionarily is critic

241 ogically, largely disrupts the photoperiodic diapause response of the wasps.

242 n the insulin signaling pathway, mediate the diapause response.

243 critical for population persistence, but key diapause responses under dry and hot conditions remain p

244 ine signaling, and metabolism that accompany diapause, several of which appear to be common features

245 l nervous system across a time series during diapause show consistent and progressive changes in tran

246 nked, QTL that overlap with QTL for stage of diapause (SOD), and a QTL that interacts epistatically w

247 elopment, particularly in the dauer larva, a diapause stage associated with longevity.

248 epletion, its young larvae enter a migratory diapause stage, called the dauer.

249 ate, transcriptionally mimicking the in vivo diapause stage.

250 eriod from the first feeding stage N3 to the diapausing stage C4).

251 that involves sexual selection, or a sexual diapausing stage that allows survival through harsh peri

252 ion and storing energy for diapause and post-diapause stages.

253 the nematode Caenorhabditis elegans enters a diapause state, termed dauer, which is accompanied by re

254 the dauer stage, a developmentally arrested diapause state.

255 ters are essential for the H4K16Ac-negative, diapause state.

256 assess whether invertebrates with different diapause strategies have converged toward similar transc

257 appears to be a general feature of cells in diapause, suggestive that this may be a mechanism to hal

258 hism results in the variable expression of a diapause syndrome that is associated with the seasonal p

259 strong candidates for implementation of the diapause syndrome.

260 lecular events occurring during diapause and diapause termination in calanoid copepods.

261 Changes in spring diapause termination in the European corn borer moth (Os

262 The phase of diapause termination is associated with enhanced transcr

263 owledge of lipid degradation pathways during diapause termination is limited.

264 After diapause termination, C. suppressalis remained in quiesc

265 s dauer state is a hibernation-like state of diapause that displays a dramatic reduction in spontaneo

266 sophila melanogaster exhibits a reproductive diapause that is variable within and among populations;

267 -16/FOXO to induce development into dauer, a diapause that withstands harsh conditions.

268 a, Coleoptera, and Hymenoptera as well as in diapauses that occur in different developmental stages (

269 n spend extended periods in a dormant stage (diapause) that is preceded by the accumulation of large

270 Diapause, the dormancy common to overwintering insects,

271 n important role in the regulation of larval diapause, the long-lived growth arrest state called daue

272 lopment and promoting long-term survival (L1 diapause), thereby providing an excellent model for the

273 and Hsp90 is actually down-regulated during diapause, thus diapause differs from common stress respo

274 ding processes that can ultimately influence diapause timing.

275 y, functions cell-intrinsically in the dauer diapause to arrest neuron morphological aging, and that

276 The photoperiod-dependent switch from diapause to reproduction is systemically transmitted thr

277 Inversions on chromosomes 1-3 affecting diapause traits adapting flies to differences in host fr

278 therefore have evidence that genes affecting diapause traits involved in host race formation reside w

279 chronize diapause with winter, and timing of diapause transitions varies widely within and among spec

280 This embryo enters embryonic diapause until the newborn leaves the pouch 9 mo later.

281 (L1s) halt development in "L1 arrest" or "L1 diapause" until ample food is encountered and triggers s

282 chlings arrest in a dormant state termed "L1 diapause" until food is supplied.

283 The diapause up-regulated Hsps include two members of the Hs

284 Sometime later (perhaps +/-1 million years), diapause variation in the latitudinal clines appears to

285 expression of downstream genes that mark the diapause vs. reproductive states of the gut.

286 ratio of female to male in the initiation of diapause was 0.22.

287 ude that the ability to undergo reproductive diapause was a key trait that facilitated colonization a

288 Our results demonstrated in Yangzhou, China, diapause was initiated between September 4 and 12, 2010.

289 elopment, and differentially regulated after diapause was pharmacologically terminated in the flesh f

290 genes based on their functional relevance to diapause, we identified five gene categories of potentia

291 describe also prevents the entry into pupal diapause when administered to larvae that are environmen

292 lic resources is critical for insects during diapause when food sources are limited or unavailable.

293 During diapause, when ATP concentrations are low, heat shock pr

294 east 100 mammalian species exhibit embryonic diapause, where fertilized embryos arrest development in

295 Cx. pipiens survive overwinter through diapause which is an important survival strategy that is

296 to meet energy requirements during dormancy (diapause), which occurs during the last copepodite stage

297 elegans larvae by promoting entry into dauer diapause, which is characterized by metabolic and anatom

298 verns glycogen and lipid biosynthesis during diapause, which is fundamental for the insect survival d

299 riod and temperature are used to synchronize diapause with winter, and timing of diapause transitions

300 uito diapause has focused primarily on adult diapause, with little current information available on l