ライフサイエンスコーパス: diapedesis

1 r initiates transendothelial migration (TEM, diapedesis).

2 s in the endothelial monolayer (paracellular diapedesis).

3 to tissues: tethering, rolling, adhesion and diapedesis.

4 rm adhesion to the nearest junction to begin diapedesis.

5 ling, activation, tight adhesion, arrest and diapedesis.

6 of endothelial barrier function and reduces diapedesis.

7 tracks oriented parallel to the direction of diapedesis.

8 signaling as well as the adhesion events of diapedesis.

9 poxin A(4) receptor (ALXR/FPRL1) to halt PMN diapedesis.

10 ability, and motility, functions critical to diapedesis.

11 tail of the migrating monocyte and complete diapedesis.

12 or vascular barrier regulation and leukocyte diapedesis.

13 and an adhesion molecule mediating leukocyte diapedesis.

14 ein-coupled chemokine receptors required for diapedesis.

15 early T cell activation and interferes with diapedesis.

16 ory disorders driven by increased neutrophil diapedesis.

17 investigated the impact of age on neutrophil diapedesis.

18 rophil extravasation by selectively blocking diapedesis.

19 a extravasation, neutrophil recruitment, and diapedesis.

20 f mechanical events involved in paracellular diapedesis.

21 receptors (ChR) for vascular wall arrest and diapedesis.

22 ad, deletion of EVL and VASP impaired T-cell diapedesis.

23 ced beta2-integrin activation and neutrophil diapedesis.

24 integrin-dependent adhesion, chemotaxis, and diapedesis.

25 n by suppressing CD200R myeloid cells during diapedesis.

26 l motility, are not obligatory for leukocyte diapedesis.

27 helial migration by accelerating the rate of diapedesis.

28 gesting that these molecules are involved in diapedesis.

29 actions may play a role in aiding neutrophil diapedesis.

30 action of serine proteases promote leukocyte diapedesis.

31 ork governing endothelial-cell regulation of diapedesis.

32 n the active role of the endothelial cell in diapedesis.

33 ptosis, vascular permeability, and leukocyte diapedesis.

34 ic activity of MMPs is not just required for diapedesis.

35 ulate a critical step required for leukocyte diapedesis.

36 lectively blocked the transcellular route of diapedesis.

37 ching for areas permissive for transcellular diapedesis.

38 oing transendothelial migration, also called diapedesis.

39 cale of neutrophil activation, adhesion, and diapedesis.

40 cellular and molecular mechanisms regulating diapedesis, a central aspect of trafficking.

41 transendothelial migration of leukocytes, or diapedesis, a critical step in the inflammatory response

42 ling to transmigration sites and compromised diapedesis across HEVs.

43 dhesive contacts was required for arrest and diapedesis across inflamed arterial endothelium to a gre

44 that contribute to monocyte recruitment and diapedesis across the endothelium.

45 a prerequisite for transcellular neutrophil diapedesis across the inflamed BBB.

46 ation of IL-1/inhibition of RXR, granulocyte diapedesis/adhesion, Fc macrophage activation, prothromb

47 the CNS is relatively resistant to leukocyte diapedesis after chemokine injection, leaving their func

48 tga4 transgene is potentially sufficient for diapedesis after intra-arterial delivery.

49 (Cx-43), known to be involved in tumor cell diapedesis and attachment to endothelial cells, is signi

50 erculosis chaperonin 60.1 inhibits leucocyte diapedesis and bronchial hyperresponsiveness in a murine

51 AGEP, converged on neutrophil chemotaxis and diapedesis and cytokines known to drive neutrophil-rich

52 nvolve chemokine-induced leukocyte adhesion, diapedesis and homing.

53 reduced signaling in leukocyte adhesion and diapedesis and increased complement signaling.

54 othelial cells is a central event leading to diapedesis and involves the binding of the I-domain of b

55 leukocyte adherence to endothelium, impaired diapedesis and less tissue necrosis in the hearts perfus

56 -lymphocyte polarization and interfered with diapedesis and migration in the narrow subendothelial sp

57 t that in addition to influencing eosinophil diapedesis and survival, anti-CCL11 has an action on T c

58 s a specific role for EVL and VASP in T-cell diapedesis and trafficking.

59 elial microtubules and kinesins in promoting diapedesis, and a mechanism to explain targeted recyclin

60 monocytes, occurred during transendothelial diapedesis, and depended on integrin lymphocyte-function

61 diverges into pathways regulating lymphocyte diapedesis, and other pathways modulating gene expressio

62 ammatory functions, including cell adhesion, diapedesis, and phagocytosis, are dependent on the mobil

63 s adhesion of leukocytes to the endothelium, diapedesis, and transmigration.

64 Our study identifies diapedesis as a step targeted by metalloproteinase activ

65 roles in immunity by facilitating leukocyte diapedesis at inflammatory sites and controlling periphe

66 Furthermore, T-cell diapedesis became equivalent between control and EVL/VAS

67 ch as Abs and soluble fusion proteins, block diapedesis both in vivo and in vitro.

68 herin, known to selectively affect leukocyte diapedesis, but not the induction of vascular permeabili

69 ons for this, here, we visualized neutrophil diapedesis by 3D intravital video microscopy in the crem

70 pothesized that VECs facilitate paracellular diapedesis by opening their cell-cell junctions in respo

71 Our findings demonstrate that diapedesis can be mechanically regulated by the transmig

72 RHP reduced poststroke leukocyte diapedesis concomitant with a long-lasting downregulatio

73 or ADAM17 or monocyte ADAM10, reproduces the diapedesis delay observed with metalloproteinase inhibit

74 ial migration and cell polarization, but not diapedesis, depended on Nef's ability to inhibit host ce

75 In contrast, TCM diapedesis did not require CXCL12 but was blocked by PTX

76 Monocyte diapedesis has been demonstrated to utilize both para an

77 ptor (uPAR; CD87) in neutrophil adhesion and diapedesis has been demonstrated with uPAR-knockout mice

78 The role of this adaptor in leukocyte diapedesis has never been investigated.

79 eukocytes and endothelial cells critical for diapedesis have been identified, but the mechanisms unde

80 use monocyte adhesion to the endothelium and diapedesis in lesion-prone regions of the vasculature is

81 (i.e., through individual endothelial cells) diapedesis in vitro and demonstrate that virtually all,

82 PECAM, fused to the Fc portion of IgG, block diapedesis in vitro and in vivo.

83 in vivo assays, and could undergo efficient diapedesis in vitro.

84 The process of diapedesis, in which the leukocyte crawls between tightl

85 This process occurs through diapedesis, in which the leukocyte moves in an ameboid f

86 However, in VEC-alpha-C mice, transcellular diapedesis increased severalfold in the omentum, but not

87 rocess occurs and whether it is required for diapedesis independent of PECAM are not known.

88 recognition triggers effector functions in a diapedesis-independent manner and is inhibited by the pr

89 migration appeared to be responsible for the diapedesis induced by interaction between CCR5 on Th1-ty

90 ie-2 by secreting Angpt1, thereby preventing diapedesis-induced leakiness.

91 brane proteins and promotes cytotoxic T cell diapedesis into inflamed tissue.

92 vivo in blocking CD11b+ monocyte/macrophage diapedesis into inflammatory lesions.

93 Stroke induced significant bilateral B cell diapedesis into remote brain regions regulating motor an

94 specifically regulate the step of leukocyte diapedesis into the CNS remain poorly understood.

95 chemokine signaling, leukocyte adhesion and diapedesis, invasive cell type-specific markers, and com

96 Diapedesis involved the homophilic interaction of CD99 o

97 Neutrophil diapedesis is an immediate step following infections and

98 Diapedesis is critical for immune system function and in

99 In addition, we found that diapedesis is facilitated when the tension fluctuations

100 Thus, diapedesis is promoted by metalloproteinase activity.

101 , called transendothelial migration (TEM) or diapedesis, is completed within 90 s after a leukocyte a

102 recycling compartment (LBRC) is required for diapedesis, is mediated by kinesin family molecular moto

103 The concept is emerging that diapedesis itself can be dissected into sequential steps

104 l-EC interactions and the subsequent mode of diapedesis, junctional or nonjunctional, can be context

105 junctions, where it functions to facilitate diapedesis, maintain vascular integrity, and transmit su

106 We propose that the progression of diapedesis may be regulated by spatial and temporal clea

107 Thus, B cell diapedesis occurred in areas remote to the infarct that

108 virtually all, both para- and transcellular, diapedesis occurs in the context of a novel "cuplike" tr

109 RANTES seemed to promote diapedesis of adherent Th1-type cells by augmenting pseu

110 the principal MAPKs involved in facilitating diapedesis of CD4(+) lymphocytes across both types of MV

111 dy was to determine if the delayed secondary diapedesis of CD8 T cells into the ischemic brain negati

112 histamine release is known to promote rapid diapedesis of inflammatory cells, we evaluated the possi

113 Diapedesis of leukocytes across endothelial cells is a c

114 CR3 is involved in endothelial adhesion and diapedesis of leukocytes at inflammatory sites.

115 agocytosis of bacteria), despite accelerated diapedesis of leukocytes into peripheral tissue, as well

116 dothelial cell adherens junctions and in the diapedesis of metastatic cancer cells.

117 ntibody to CD99, hec2, selectively inhibited diapedesis of monocytes across endothelial cells by >90%

118 olecules (CAMs) involved in the adhesion and diapedesis of monocytes and the adherence of SS reticulo

119 th IL-4 did not affect the time required for diapedesis of monocytes itself.

120 ant stress leading to increased adhesion and diapedesis of monocytes, as well as heightened adherence

121 motor domain blocked targeted recycling and diapedesis of monocytes.

122 mice, and correspondingly, there was reduced diapedesis of peripheral macrophages in the IL-1R1 null

123 nin-positive cells, consistent with a faster diapedesis of peripheral monocytes and neutrophils.

124 Diapedesis of stationary neutrophils was unchanged by th

125 ition of the endothelium results in enhanced diapedesis of T cells into the tissue, while not affecti

126 ation is driven by excessive transmigration (diapedesis) of leukocytes from the blood to the tissue a

127 es TNF-dependent transendothelial migration (diapedesis) of naive T cells by modulating molecular ass

128 irm a detrimental role of chronic CD8 T cell diapedesis on recovery, peripheral CD8 T cells were depl

129 ime required for human monocytes to complete diapedesis on unactivated or inflamed human endothelium,

130 eukocytes across endothelium [referred to as diapedesis or transendothelial migration (TEM)] is a cri

131 contractile actin filaments surrounding the diapedesis pore, keeping this opening tightly closed aro

132 endothelial MAPKs ERK, p38, and JNK mediate diapedesis-related and diapedesis-unrelated functions of

133 dothelial barrier integrity during leukocyte diapedesis requires local endothelial RhoA cycling.

134 ntation prevented CD8(+) T cell crawling and diapedesis resulting in brain endothelial cell apoptosis

135 in all types of venules and can modulate the diapedesis route.

136 ctivated T-cell trafficking by promoting the diapedesis step of transendothelial migration in a alpha

137 ial cell junctions, indicating that only the diapedesis step was blocked by interference with CD99.

138 M is a molecule used specifically during the diapedesis step when neutrophils and monocytes leave the

139 that precede it, transendothelial migration (diapedesis), the step in which leukocytes migrate betwee

140 Therefore, diapedesis, the forward migration of leukocytes through

141 romising, but MSCs are missing machinery for diapedesis through blood-brain barrier.

142 has been shown to be important for leukocyte diapedesis through brain microvessels and subsequent bin

143 ficiency promoted the transcellular route of diapedesis through endothelial cell.

144 the cell will spread and will either undergo diapedesis through individual vascular endothelial cells

145 clude that specifically targeting neutrophil diapedesis through the endothelial barrier may represent

146 l inflammatory models, that it is neutrophil diapedesis through the endothelial barrier that is respo

147 visualized and quantified poststroke B cell diapedesis throughout the brain, including remote areas

148 r walls, thus causing neutrophils engaged in diapedesis to reenter the systemic circulation.

149 se, which involves intraluminal crawling and diapedesis to the extravascular space, remains elusive.

150 um supports neutrophil arrest, crawling, and diapedesis under physiological flow in vitro.

151 p38, and JNK mediate diapedesis-related and diapedesis-unrelated functions of ICAM-1 in cerebral and

152 sponses were measured by flow cytometry, and diapedesis was assessed using transwell plates.

153 8+ cells to microvasculature was normal, the diapedesis was significantly impaired.

154 y, the hypothesis that systemic LPS inhibits diapedesis was tested by injection of LPS ip and ivt sim

155 Based on its postulated role in diapedesis, we have investigated the role of Plvap in he

156 steps: adhesion, junctional recognition, and diapedesis; we further demonstrate that ICAM-2 is expres

157 A-4 may serve to facilitate transendothelial diapedesis, whereas late and prolonged activation of VLA

158 cell-cell junction remodeling, adhesion, and diapedesis, which corresponded with lower plasma levels

159 s modulator of the final steps of neutrophil diapedesis, with potential translational implications fo

160 ed granulocyte and agranulocyte adhesion and diapedesis, wound healing, IL-8 signaling, and IL-17-rel