ライフサイエンスコーパス: diastereo-

1 cts are generated in good yield (31 to 98%), diastereo- (3:1 to >30:1), and enantioselectivity (90:10

2 yrolactones were engaged in a highly regio-, diastereo-, and enantio-selective Lewis base asymmetric

3 ester reduction, excellent levels of chemo-, diastereo-, and enantiocontrol can be realized in the re

4 on of cyclobutanones, with excellent regio-, diastereo-, and enantiocontrol, under mild conditions (2

5 The addition occurs with high regio-, diastereo-, and enantiocontrol.

6 acid (R,R-1) was developed with high regio-, diastereo-, and enantiocontrol.

7 n good yields, with rigorous chemo-, regio-, diastereo-, and enantiocontrol.

8 eaction partner and with outstanding regio-, diastereo-, and enantiocontrol.

9 r mild reaction conditions with high regio-, diastereo-, and enantiocontrol.

10 to excellent yields and as a single regio-, diastereo-, and enantiomer is described.

11 The chemo-, regio-, diastereo-, and enantioselective 1,2-oxyamination of alk

12 A regio-, diastereo-, and enantioselective [4+3] cycloaddition bet

13 d aldol addition reaction in 1973, the site, diastereo-, and enantioselective aldol reaction has been

14 The first regio-, diastereo-, and enantioselective allylic alkylation of a

15 A highly regio-, diastereo-, and enantioselective allylic alkylation reac

16 iscovery and development of a site-, regio-, diastereo-, and enantioselective aryl C-H bond cycloprop

17 cleophiles to mediate highly chemo-, regio-, diastereo-, and enantioselective C-C bond forming reacti

18 A Cu-catalyzed regio-, diastereo-, and enantioselective carboboration of 1,1-bi

19 s allylmetal pronucleophiles in regio-, anti-diastereo-, and enantioselective carbonyl addition from

20 ate complex, we can achieve a highly regio-, diastereo-, and enantioselective construction of polysub

21 Regio-, diastereo-, and enantioselective coupling reactions betw

22 the difficulty in developing chemo-, regio-, diastereo-, and enantioselective cycloadditions has limi

23 d to Cu catalysis and allows for the regio-, diastereo-, and enantioselective formation of synthetica

24 An organocatalytic and highly regio-, diastereo-, and enantioselective intermolecular haloethe

25 3]dendralenes undergo highly chemo-, regio-, diastereo-, and enantioselective organocatalyzed Diels-A

26 e report a new method for the highly regio-, diastereo-, and enantioselective palladium-catalyzed all

27 re thus turned into highly efficient gamma-, diastereo-, and enantioselective transformations that ex

28 A highly regio-, diastereo-, and enantioselective, scalable Ir-catalyzed

29 ion 4, in high yields with excellent regio-, diastereo-, and enantioselectivities (>95:5 dr and up to

30 ing quaternary, in excellent chemo-, regio-, diastereo-, and enantioselectivities in high chemical yi

31 vicinal stereocenters with excellent regio-, diastereo-, and enantioselectivities, forging products t

32 tuted hydroquinolines with excellent regio-, diastereo-, and enantioselectivities.

33 diaminated in good yields with high regio-, diastereo-, and enantioselectivities.

34 acids in high yields with excellent regio-, diastereo-, and enantioselectivities.

35 rresponding aldol products with high regio-, diastereo-, and enantioselectivities.

36 yields and with excellent control of peri-, diastereo-, and enantioselectivities.

37 formed in good yields and excellent regio-, diastereo-, and enantioselectivities.

38 chlorolactonization suffers from low chemo-, diastereo-, and enantioselectivities.

39 azines in high yields with excellent regio-, diastereo-, and enantioselectivities.

40 yields (86-98%) and with outstanding regio-, diastereo-, and enantioselectivity (88-99% ee).

41 The processes occur with high regio-, diastereo-, and enantioselectivity and offer unusual exa

42 tuted styrenes established trends in chemo-, diastereo-, and enantioselectivity and provided insights

43 reaction can proceed with very high regio-, diastereo-, and enantioselectivity and represents a surr

44 The method exhibits excellent regio-, diastereo-, and enantioselectivity and tolerates a range

45 substituted cyclic dienones with high site-, diastereo-, and enantioselectivity has been achieved.

46 The high levels of regio-, anti diastereo-, and enantioselectivity observed in these rea

47 ion pathway accounts for the observed peri-, diastereo-, and enantioselectivity of the organocatalyti

48 structurally complex products in high peri-, diastereo-, and enantioselectivity with moderate yield.

49 To augment or invert regio-, diastereo-, and enantioselectivity, predominantly one fr

50 osyl aldimines and ketimines in high regio-, diastereo-, and enantioselectivity.

51 red with similar high efficiency and regio-, diastereo-, and enantioselectivity.

52 icyclo[4.3.1]decadienes in excellent regio-, diastereo-, and enantioselectivity.

53 ffords C-alkylation products in high regio-, diastereo-, and enantioselectivity.

54 gucycline bay region with control of regio-, diastereo-, and enantioselectivity.

55 is achieved with high levels of regio-, anti-diastereo-, and enantioselectivity.

56 core and all stereocenters with high regio-, diastereo-, and enantioselectivity.

57 obtained in high yield and with good regio-, diastereo-, and enantioselectivity.

58 3z, 3a'-3c' with high levels of regio-, anti-diastereo-, and enantioselectivity.

59 ed dihydro-1,2-oxazines in excellent regio-, diastereo-, and enantioselectivity.

60 ted beta-amino ynones with excellent chemo-, diastereo-, and enantioselectivity.

61 5a-5o with excellent control of regio-, anti-diastereo-, and enantioselectivity.

62 c alcohols with excellent control of regio-, diastereo-, and enantioselectivity.

63 distinguished by excellent levels of chemo-, diastereo-, and enantioselectivity; moreover, it can be

64 ransformation with excellent chemo-, regio-, diastereo-, and enantioselectivtities, leading to valuab

65 The development of the first enantio-, diastereo-, and regioselective iridium-catalyzed allylic

66 in high yields and with excellent enantio-, diastereo-, and regioselectivity through catalytic asymm

67 l possible stereoisomers with high enantio-, diastereo-, and regioselectivity.

68 nale for the origins of the observed regio-, diastereo-, and stereoselectivity and of the unusual rea

69 rrelene ligand (Ph-tfb) enable the enantio-, diastereo-, and Z-selective a,d-difunctionalization of e

70 ward enantiopure B-amino acid derivatives by diastereo- and chemoselective reduction.

71 d enantiopure beta-amino acid derivatives by diastereo- and chemoselective reduction.

72 The diastereo- and chemoselectivity of this reaction was tes

73 , showcasing its broad substrate scope, high diastereo- and E/Z selectivity, and yielding good to exc

74 irconium nucleophiles undergo highly regio-, diastereo- and enantio-selective Cu-catalyzed desymmetri

75 We report a biocatalyst for diastereo- and enantio-selective synthesis of cis-CF(3)

76 oxalines in high yields with almost complete diastereo- and enantiocontrol (>20 : 1 dr, up to >99 % e

77 tanes in generally good yields and excellent diastereo- and enantiocontrol (up to >95 : 5 dr, 97 : 3

78 razones as carbene precursors with excellent diastereo- and enantiocontrol (up to 2500 TTN, >99% dr,

79 ters, giving anti-dihydropyranones with high diastereo- and enantiocontrol (up to 98:2 dr, up to 99%

80 g carbo- and heterocyclic products with high diastereo- and enantiocontrol (up to 99:1 dr, up to 99%

81 first two stereogenic centers with excellent diastereo- and enantiocontrol followed by zinc-mediated

82 merization, furnishing carbocycles with high diastereo- and enantiocontrol from easily accessible pre

83 In the benzaldehyde series, optimal product diastereo- and enantiocontrol is observed using 2-nitrob

84 llel kinetic resolution, achieving excellent diastereo- and enantiocontrol over radical intermediates

85 r their construction, particularly with high diastereo- and enantiocontrol, are of high importance.

86 The [3,3]-rearrangement occurs with high diastereo- and enantiocontrol, forming beta-imino amides

87 angement in good overall yield and with good diastereo- and enantiocontrol.

88 ic centers at the ring fusion with excellent diastereo- and enantiocontrol.

89 The first diastereo- and enantiodivergent asymmetric synthesis of

90 of the stereochemical dyad, affording fully diastereo- and enantiodivergent biotransformations in as

91 yclic amine substrate with enzyme-controlled diastereo- and enantiodivergent selectivity.

92 four contiguous stereocenters with complete diastereo- and enantiomeric control by a formal [2 + 2]-

93 ched/linear or exo/endo ratios and excellent diastereo- and enantiomeric excesses when in situ formed

94 the addition products were obtained in high diastereo- and enantiomeric purity.

95 eated in a single-pot operation in excellent diastereo- and enantiomeric ratios.

96 easily access these strained rings with high diastereo- and enantiomeric ratios.

97 alytic multi-component process that delivers diastereo- and enantiomerically enriched tertiary homoal

98 verted, in situ, to the catalytically active diastereo- and enantiomerically pure N-heterocyclic carb

99 The preparation of diastereo- and enantiopure 1,2-amino alcohols is also re

100 o orthogonal mechanisms and are converted to diastereo- and enantiopure amines bearing adjacent stere

101 ional handles, this method enables access to diastereo- and enantiopure cyclopropanes and derivatives

102 Herein, four new fluorinated diastereo- and enantiopure isatin sulfonamide-based pote

103 erved during the asymmetric synthesis of the diastereo- and enantiopure oxahelicenes.

104 ranched and functionalized aldehydes of high diastereo- and enantiopurity.

105 l-containing side chains with high levels of diastereo- and enantioselection.

106 tive substrates for catalytic multicomponent diastereo- and enantioselective 1,6-conjugate addition o

107 nthesis has been accomplished using a highly diastereo- and enantioselective [4 + 2] annulation for t

108 We report herein a Cu-catalyzed regio-, diastereo- and enantioselective acylboration of 1,3-buta

109 ghly effective in promoting the first direct diastereo- and enantioselective addition of alkylazaaren

110 The first highly diastereo- and enantioselective additions of a halogen a

111 Highly diastereo- and enantioselective additions of substituted

112 An efficient diastereo- and enantioselective Ag-catalyzed method for

113 ophiles in ruthenium-JOSIPHOS-catalyzed anti-diastereo- and enantioselective aldehyde (a-aryl)allylat

114 We report a highly diastereo- and enantioselective allylation of azlactones

115 We report highly diastereo- and enantioselective allylations of substitut

116 ric Mannich-type reactions led to the highly diastereo- and enantioselective and concise synthesis of

117 is was explored in the development of highly diastereo- and enantioselective Au(I)-catalyzed cycloadd

118 Herein, we report a highly diastereo- and enantioselective biocatalytic transaminat

119 as nucleophiles to engage in chemo-, regio-, diastereo- and enantioselective C-C bond-forming reactio

120 of C-C coupling in ruthenium-catalyzed anti-diastereo- and enantioselective C-C couplings of primary

121 Thus, anti-diastereo- and enantioselective carbonyl crotylation fro

122 A highly chemo-, diastereo- and enantioselective catalytic method that ef

123 tly improve a transformation, or develop new diastereo- and enantioselective catalytic methods are pr

124 tic strategy is reported here for the highly diastereo- and enantioselective construction of stereoch

125 hale myoglobin is shown to enable the highly diastereo- and enantioselective construction of these mo

126 ing ethyl- and phenyl-substituents engage in diastereo- and enantioselective coupling, as illustrated

127 A diastereo- and enantioselective CuH-catalyzed method for

128 ue from the paraherquamide pathway) catalyse diastereo- and enantioselective cyclization in the const

129 of cytochrome P450(BM3) that catalyze highly diastereo- and enantioselective cyclopropanation of styr

130 The key to the process was a diastereo- and enantioselective cyclopropanation of the

131 A novel Cu-catalyzed diastereo- and enantioselective desymmetrization of cycl

132 heir reactivity is unveiled through a highly diastereo- and enantioselective Diels-Alder/lactonizatio

133 catalysts was explored in the development of diastereo- and enantioselective direct aldol reactions o

134 rovide reagent (catalyst)-controlled, highly diastereo- and enantioselective direct aza-Henry reactio

135 A highly diastereo- and enantioselective exo-Diels-Alder reaction

136 We describe a palladium-catalyzed diastereo- and enantioselective formal [3 + 2]-cycloaddi

137 The first catalytic diastereo- and enantioselective hydroformylation of cycl

138 describe herein an iridium-catalyzed highly diastereo- and enantioselective hydrogenation of 1,2-aza

139 Moreover, regiodivergent, diastereo- and enantioselective incorporation of the all

140 mal reaction conditions to accomplish highly diastereo- and enantioselective intramolecular [4+2]-cyc

141 tabilized cyclic ketone enolates can undergo diastereo- and enantioselective Ir-catalyzed allylic sub

142 A highly diastereo- and enantioselective Mannich-type reaction of

143 A highly diastereo- and enantioselective method for the epoxidati

144 A catalytic diastereo- and enantioselective method for the preparati

145 to the reaction mixture leads to the highly diastereo- and enantioselective one-pot synthesis of dia

146 A diastereo- and enantioselective organocatalytic aldol re

147 A catalytic sequence for the diastereo- and enantioselective preparation of homoallyl

148 tion reagents is described, including highly diastereo- and enantioselective preparation of numerous

149 A concise diastereo- and enantioselective route that furnishes the

150 tecting group-free strategy is presented for diastereo- and enantioselective routes that can be used

151 Here we introduce a catalytic regio-, diastereo- and enantioselective strategy for the prepara

152 appa agonists restricted to the periphery, a diastereo- and enantioselective synthesis of (4aR,5S,8aS

153 The first catalytic method for diastereo- and enantioselective synthesis of allylic bor

154 The first highly diastereo- and enantioselective synthesis of armeniaspir

155 pling of carboxamides with ketimines for the diastereo- and enantioselective synthesis of beta-amino

156 chiral silane Lewis acid leads to the highly diastereo- and enantioselective synthesis of beta-chloro

157 efficient biocatalytic method for the highly diastereo- and enantioselective synthesis of CHF(2) -con

158 Here, a novel strategy is reported for the diastereo- and enantioselective synthesis of cyclopropan

159 ) aldol lactonization (NCAL) process for the diastereo- and enantioselective synthesis of N-heterocyc

160 MeOH conditions, resulted in an exceedingly diastereo- and enantioselective synthesis of talo-gamma-

161 constitutes an efficient approach for highly diastereo- and enantioselective synthesis of tetrahydrof

162 Here, we report a catalytic, diastereo- and enantioselective three-component strategy

163 A convergent diastereo- and enantioselective total synthesis of antic

164 Moreover, both diastereo- and enantioselective variants of this methodo

165 Finally, diastereo- and enantioselective versions of the title re

166 We report a highly regio-, diastereo- and enantioselective vicinal dihalogenation o

167 and afforded anti-Mannich products with high diastereo- and enantioselectivities (anti/syn up to 99:1

168 ided the bicyclic derivatives with excellent diastereo- and enantioselectivities (up to >20:1 dr and

169 The observed diastereo- and enantioselectivities are determined by bo

170 s were obtained in high yields and excellent diastereo- and enantioselectivities from gamma-substitut

171 2 are obtained in high yields with excellent diastereo- and enantioselectivities from stereochemicall

172 mechanical calculations reveal the origin of diastereo- and enantioselectivities of aldol reactions b

173 pper salt, and site of C-H insertion on both diastereo- and enantioselectivities of these intramolecu

174 Accomplishing high diastereo- and enantioselectivities simultaneously is a

175 In most cases, both excellent diastereo- and enantioselectivities were achieved.

176 With doubly substituted enol lactones, high diastereo- and enantioselectivities were obtained, thus

177 ble homoallylic alcohols with high levels of diastereo- and enantioselectivities, and in the presence

178 quaternary stereocenters in high yields and diastereo- and enantioselectivities.

179 ive trisubstituted aziridines with excellent diastereo- and enantioselectivities.

180 products in high yield and with exceptional diastereo- and enantioselectivities.

181 nd provided the Michael adducts in excellent diastereo- and enantioselectivities.

182 obutanol substrates proceeded with excellent diastereo- and enantioselectivities.

183 d the products in excellent yields with high diastereo- and enantioselectivities.

184 ffords aldol products with good to excellent diastereo- and enantioselectivities.

185 nantioenriched decahydroquinolines with high diastereo- and enantioselectivities.

186 ereocenters-are obtained in moderate to high diastereo- and enantioselectivities.

187 btained in moderate to good yields with high diastereo- and enantioselectivities.

188 acemic spirocyclic ketones with high yields, diastereo- and enantioselectivities.

189 btained in good to high yields and excellent diastereo- and enantioselectivities.

190 gs in high yields and with good to excellent diastereo- and enantioselectivities.

191 bserved, giving beta-lactones with excellent diastereo- and enantioselectivity (34 examples, up to >9

192 opanes in high yields (61-99%) and excellent diastereo- and enantioselectivity (97-99.9% de and ee).

193 inhibitor) in high yield and with excellent diastereo- and enantioselectivity (98-99.9% de; 96-99.9%

194 iency (up to 46,800 turnovers) and excellent diastereo- and enantioselectivity (98-99.9%) was develop

195 ketone to form a range of diamides with high diastereo- and enantioselectivity (up to >95:5 dr and >9

196 -alpha-amino acid derivatives with excellent diastereo- and enantioselectivity (up to >95:5 dr; up to

197 oups, a broad scope of substrates, excellent diastereo- and enantioselectivity (up to 20 : 1 dr, 99 %

198 fins to produce cyclopropanes with excellent diastereo- and enantioselectivity and in high yield.

199 Rates, yields, turnover, diastereo- and enantioselectivity are comparable with co

200 the electron-donating alkoxy group, whereas diastereo- and enantioselectivity have a complex origin,

201 ized with different catalysts, and excellent diastereo- and enantioselectivity have been achieved.

202 Furthermore, high degrees of diastereo- and enantioselectivity have been observed in

203 an Ir(III) photocatalyst, yet high levels of diastereo- and enantioselectivity in a [2 + 2] photocycl

204 idual stereoisomers and showed a significant diastereo- and enantioselectivity in HIV-1 inhibition, t

205 The origin of the observed diastereo- and enantioselectivity in the enzyme was inve

206 are exploited to enforce high levels of anti-diastereo- and enantioselectivity in the formation of an

207 etrasubstituted carbon stereocenters in high diastereo- and enantioselectivity in the presence of sta

208 The step leading to diastereo- and enantioselectivity is an asymmetric Picte

209 ding BINOL-derived systems, and the opposite diastereo- and enantioselectivity is observed.

210 Notably, the observed diastereo- and enantioselectivity is the opposite of tha

211 The diastereo- and enantioselectivity obtained experimentall

212 The diastereo- and enantioselectivity obtained experimentall

213 te selectivity of arene coordination and the diastereo- and enantioselectivity of the hydrogenation r

214 emical model is provided to explain the high diastereo- and enantioselectivity of this process.

215 tereoselectivity that allows for controlling diastereo- and enantioselectivity only by the choice of

216 r can be formed in good yield with excellent diastereo- and enantioselectivity simply by switching th

217 that generates eight stereocenters with high diastereo- and enantioselectivity through asymmetric rev

218 d point chirality were synthesized with good diastereo- and enantioselectivity under mild conditions.

219 The key for achieving excellent diastereo- and enantioselectivity was substitution on a

220 ond formation 4a-4l with good levels of anti-diastereo- and enantioselectivity.

221 ing either the syn- or anti-adduct with high diastereo- and enantioselectivity.

222 high yields with good to excellent levels of diastereo- and enantioselectivity.

223 alcohol derivatives with excellent levels of diastereo- and enantioselectivity.

224 f propargylamines can be synthesized in high diastereo- and enantioselectivity.

225 tionalized products with catalyst-controlled diastereo- and enantioselectivity.

226 l-carbon quaternary centers with exceptional diastereo- and enantioselectivity.

227 ceeds in nearly quantitative yield with high diastereo- and enantioselectivity.

228 vement to those reported earlier in terms of diastereo- and enantioselectivity.

229 aziridine-2-carboxylic esters with very high diastereo- and enantioselectivity.

230 uous stereocenters in high yields, with good diastereo- and enantioselectivity.

231 etric byproducts and with high levels of syn-diastereo- and enantioselectivity.

232 rature, resulting in enhanced levels of anti-diastereo- and enantioselectivity.

233 opane products in high yields with both high diastereo- and enantioselectivity.

234 ed and brominated variants, formed with high diastereo- and enantioselectivity.

235 erate to good yields and with high levels of diastereo- and enantioselectivity.

236 r bonds in a single operation with excellent diastereo- and enantioselectivity.

237 prepared in good yields, with high levels of diastereo- and enantioselectivity.

238 -functionalized allyl silyl ethers with high diastereo- and enantioselectivity.

239 variety of aromatic aldehydes with excellent diastereo- and enantioselectivity.

240 ha-hydroxy ester in good yield and excellent diastereo- and enantioselectivity.

241 escribed that occur with high levels of anti-diastereo- and enantioselectivity.

242 adducts could be formed with a high level of diastereo- and enantioselectivity.

243 crotylation with good to excellent levels of diastereo- and enantioselectivity.

244 of the diene partner with usually excellent diastereo- and enantioselectivity.

245 c 1,2-amino tertiary alcohols with excellent diastereo- and enantioselectivity.

246 -butyrolactone in good yield, with excellent diastereo- and enantioselectivity.

247 hed regioselectivity and high levels of anti-diastereo- and enantioselectivity.

248 zolines were obtained with good to excellent diastereo- and enantioselectivity.

249 to afford a protected precursor in excellent diastereo- and enantioselectivity.

250 nePhos complex plays a key role in directing diastereo- and enantioselectivity.

251 s syn-alpha-amino acid derivatives with high diastereo- and enantioselectivity.

252 yl glycolate derivatives with high levels of diastereo- and enantioselectivity.

253 chiral [3.1.0]-bicyclic aziridines with high diastereo- and enantioselectivity.

254 n high yields with effective control of both diastereo- and enantioselectivity.

255 s in high chemical yield with high levels of diastereo- and enantioselectivity.

256 alcohols with high levels of chemo-, regio-, diastereo- and enantioselectivity.

257 rnary stereocenter with excellent control of diastereo- and enantioselectivity.

258 4a-4l with roughly equivalent levels of anti-diastereo- and enantioselectivity.

259 ated cyclopropane derivatives with excellent diastereo- and enantioselectivity; moreover, a cycloprop

260 onalized 2-iminothiazolidines with excellent diastereo- and enantiospecificity (de, ee up to >99%).

261 l transfer products in high yields with good diastereo- and excellent enantioselectivities.

262 substituted indoles proceed with negligible diastereo- and excellent enantioselectivities.

263 rnary stereocenter, generally with excellent diastereo- and high enantioselectivity.

264 This article presents complete diastereo- and highly enantioselective synthesis of nitr

265 lanes proceed in good yields giving a single diastereo- and regioisomer of the branched allylic aceta

266 promote the cascade process and control the diastereo- and regioisomeric preferences of the 1-pyrrol

267 and excellent enantioselectivities as single diastereo- and regioisomers.

268 romatization of 3,4-disubstitued phenols and diastereo- and regioselective epoxidation is described.

269 t the utility of the approach; this includes diastereo- and regioselective epoxide formation/trichlor

270 Key transformations include a diastereo- and regioselective Pd-mediated intramolecular

271 ons, the cycloaddition reactions were highly diastereo- and regioselective to yield, in most of the c

272 The first highly efficient, diastereo- and regioselective transition metal-catalyzed

273 earth abundant Zn as catalyst and is highly diastereo- and regioselective.

274 The methods reported herein diastereo- and regioselectively proceed under straightfo

275 hotochemistry can be used to gain control of diastereo- and regioselectivities in the formation of th

276 e we report a new synthetic approach of high diastereo- and regioselectivity for functionalization of

277 The observed diastereo- and regioselectivity of cycloaddition reactio

278 azaspiro-fused tricyclic scaffolds with high diastereo- and regioselectivity, highlighting its versat

279 coumarin, delivering products with excellent diastereo- and regioselectivity.

280 This synopsis provides a detailed summary of diastereo- and/or enantioselective chemical transformati

281 20 g L(-1) olefin substrate with no loss in diastereo- and/or enantioselectivity.

282 ed in excellent yield (up to 96%) as well as diastereo- (>20:1) and enantioselectivity (up to 99.5% e

283 These allylboranes undergo highly diastereo- (> or = 90: 10) and enantioselective (typical

284 N,N-diprotected 1,2-diamines with no loss in diastereo- or enantioselectivity.

285 ds (Mannich products) in excellent enantio-, diastereo-, regio-, and chemoselectivities.

286 l aldimines in high yield and with excellent diastereo- (up to >20:1) and enantioselectivity (up to 9

287 72-95% yields after purification) as well as diastereo- (up to >98:2 dr) and enantioselectivity (up t

288 d to excellent yield and with high levels of diastereo- (up to >99:1 dr) and enantiocontrol (up to 99

289 reocenter with high enantio- (ca. 93% e.e.), diastereo- (up to 25:1 d.r.), and regioselectivity (>50: