ライフサイエンスコーパス: diastereoisomer

1 stereoisomer) and (+/-)-isosolenopsin A (cis diastereoisomer).

2 ucture of the berkelic acid core as a single diastereoisomer.

3 ubstituted octahydro[2]pyrindene as a single diastereoisomer.

4 rovide allenyl alcohol product 3 as a single diastereoisomer.

5 ct with four stereogenic centers as a single diastereoisomer.

6 omeric ratio up to 7.5:1 in favor of the syn diastereoisomer.

7 stereoselective manner, leading to a single diastereoisomer.

8 irreversible conversion to a single, stable diastereoisomer.

9 ratio larger than 95:5 in favor of the anti-diastereoisomer.

10 aminophosphonate being obtained as the major diastereoisomer.

11 aside from deuteration, which gives the cis-diastereoisomer.

12 n diastereoisomers, two of the four possible diastereoisomers.

13 r protection, and were isolated as phosphate diastereoisomers.

14 of the four possible 3,4-difluoro-l-proline diastereoisomers.

15 a different cytostatic activity for the two diastereoisomers.

16 center and therefore can occur as 2 distinct diastereoisomers.

17 reby validating the fluorous-tag encoding of diastereoisomers.

18 ohols gave the monoprotected diols as single diastereoisomers.

19 itivity for different positional isomers and diastereoisomers.

20 ligonucleotides comprise complex mixtures of diastereoisomers.

21 ion states responsible for forming different diastereoisomers.

22 g dimers as well as four dominant regio- and diastereoisomers.

23 ctroscopic data suggest that 7 exists as two diastereoisomers.

24 ghly enantioenriched cyclopropanes as single diastereoisomers.

25 a 1:1 mixture of activated phosphonate ester diastereoisomers.

26 he NAMs, SAMs, and type I PAMs are cis-trans-diastereoisomers.

27 SH-related products including positional and diastereoisomers.

28 n, results in an equilibrium mixture of four diastereoisomers.

29 MND and the simultaneous appearance of ketol diastereoisomers.

30 s some chiral separations of enantiomers and diastereoisomers.

31 reliability of stereochemistry assignment of diastereoisomers.

32 hile 1,2,2-trisubstituted systems afford syn-diastereoisomers.

33 in the presence of DCC and DMAP provided two diastereoisomers, 18 and 19, which were separated by fla

34 nt here the first synthesis of the 6S and 6R diastereoisomers 2 and 3, which represent analogues of (

35 of the major metabolites of 2 is its P1-(R)-diastereoisomer, 3 (VRT-394), containing an inversion at

36 mixture several times to obtain the desired diastereoisomer (39%) for further coupling with the d-ri

37 d pyrrolidin-2-ones 5 are isolated as single diastereoisomers (40 examples, 33-84% yield).

38 chloride, the most effective receptor is the diastereoisomer 4ii with the two P horizontal lineO grou

39 totoxin (1) delivered, in addition to 4, its diastereoisomers 85-epi-QRSTU and 86-epi-QRSTU ring syst

40 zep ane as the major product and as a single diastereoisomer after chromatography.

41 tional isomers were also resolved to several diastereoisomers, although their stereostructures could

42 s substantially different for the 6R- and 6S-diastereoisomers and (18)F-2 Excellent KB tumor visualiz

43 ssigned on the basis of COSY spectra of both diastereoisomers and confirmed by HMQC spectra.

44 -bisphosphate but not by their nonbiological diastereoisomers and depends on PH domain mediated bindi

45 tal and molecular structures of 134 pairs of diastereoisomers and of 279 racemic-homochiral pairs wer

46 Many of which could be isolated as single diastereoisomers and without significant erosion of ee,

47 hetic route toward (+/-)-solenopsin A (trans diastereoisomer) and (+/-)-isosolenopsin A (cis diastere

48 Trianglamine [(+/-)Delta, (mixture of diastereoisomers) and (R,R)(3)Delta and (S,S)(3)Delta],

49 oxy-3-methylnonan-4-one (syn- and anti-ketol diastereoisomers) and 3-hydroxy-3-methyl-2,4-nonanedione

50 he interaction is markedly different between diastereoisomers, and multiple preferred conformations e

51 tected iodoalanine that yielded a mixture of diastereoisomers, and one utilized a trityl-protected io

52 elf is found to have the ability to identify diastereoisomers, and simultaneous use of these chiropti

53 te, carpanone and a so far unknown carpanone diastereoisomer are formed in a 9:1 ratio.

54 s in the VT CD spectra indicate that the two diastereoisomers are interconverting slowly in solution

55 Only two of the four possible diastereoisomers are observed, with diastereomeric ratio

56 For chiral amines, inherently chiral diastereoisomers are observed.

57 uctural studies showed that four macrocyclic diastereoisomers are possible: two S(n) symmetric achira

58 ith the configuration of the matched/matched diastereoisomer as S(c),S(p),S(phos) (97% ee).

59 These compounds exist as libraries of diastereoisomers as a result of their multiple stereoele

60 us crystal diffraction analyses suggested 16 diastereoisomers associated with matrine's four carbon s

61 ces for the protons corresponding to the two diastereoisomers at a range of coalescence temperatures

62 could be perfectly assembled, with a single diastereoisomer being obtained.

63 f nonactin and all-(-)-nonactin; the natural diastereoisomer bound K(+) 880-fold better than all-(-)-

64 )-Dihydrothiazoles 6 can be isolated as pure diastereoisomers by column chromatography.

65 l synthesis of (+)-giganin and its unnatural diastereoisomer (+)-C10-epi-giganin has been completed i

66 ation around the alpha carbon and mixture of diastereoisomers (chloroephedrine and chloropseudoephedr

67 eactions to the synthesis of four propionate diastereoisomers combining an aldol reaction, followed b

68 les the isolation of sp(3)-rich indolizidine diastereoisomers containing five stereocenters, as singl

69 tion influenced DNA cleavage, metallopeptide diastereoisomers containing L- and D-Arg (or Lys) within

70 The high bioavailability of both diastereoisomers contrasts with previous findings for th

71 different functional groups on each possible diastereoisomer controls their thermodynamic stability a

72 electivity (about 120:1) with respect to its diastereoisomer, CP-97,587 (5), which differs structural

73 Here we show that a diastereoisomer, D-GlcNalpha1-6-L-myo-inositol-1-P-sn-1,

74 The final lactones were obtained as single diastereoisomers, demonstrating that the mixture of the

75 conformational enantiomers or conformational diastereoisomers depending on the local symmetry of the

76 he interconversion of the two conformational diastereoisomers derived from each configurationally ena

77 e is known about the pharmacokinetics of the diastereoisomers, despite current interest in developing

78 The diastereoisomers differ in the relative spatial orientat

79 amic equimolar mixture of two conformational diastereoisomers, differing in the spatial (clockwise an

80 relative to each other, and thus, individual diastereoisomers display different backbone carbon chain

81 livered approximate 1:1 mixtures of syn/anti diastereoisomers due to tiny differences (<0.5 kcal/mol)

82 n positive and negative electrospray and the diastereoisomers ephedrine and pseudoephedrine in positi

83 UHPLC can separate the diastereoisomers (epicoprostanol, coprostanol, and chole

84 e explored as P2' ligands providing pairs of diastereoisomers epimeric at P2', which exhibited distin

85 nges the rates and mechanisms by which these diastereoisomers equilibrate.

86 NP)]PF(6) as a mixture of noninterconverting diastereoisomers (ester group of 3b trans to P, 5b; or t

87 (18)F-rhPSMA-7, and its single diastereoisomer form, (18)F-rhPSMA-7.3, are prostate-spe

88 hirality by lithiation, with the alternative diastereoisomer formed by use of a deuterium blocking gr

89 ction yielded a mixture of mononuclear Re(I) diastereoisomers, formulated as fac-[Br(CO)(3)Re((S/R))L

90 CH coupling constants to derive the correct diastereoisomer from the molecular constitution of small

91 se of a cyclic procedure where the two minor diastereoisomers from a chiral Lewis acid-catalyzed reac

92 ation, an excess of any one of four possible diastereoisomers from the addition of a thiol and an alk

93 olases are highly discriminating between the diastereoisomers fructose bisphosphate and tagatose bisp

94 HPLC separation of the diastereoisomers gave pure 3a whose absolute and relativ

95 oxylated piperidines were isolated as single diastereoisomers (>99:1 dr) in good overall yield.

96 show that the 2-hydroxyterpenylic acid 2R,3R diastereoisomer has a time profile distinctly different

97 hemistry of the phosphorus center of the two diastereoisomers has been suggested.

98 All three carpanone diastereoisomers have been separated by HPLC, and their

99 s highly charge-polarized, wherein different diastereoisomers have distinctively different charge pol

100 ally obtained in high yields and as a single diastereoisomer having the (R*,R*) relative configuratio

101 ingin and neohesperidin, each comprising two diastereoisomers having different bioactivities.

102 tereoselectivities were in favor of a single diastereoisomer (I) in all but one case (2-CO(2)R).

103 molecules may then lead to the formation of diastereoisomers, if the enantiomeric interaction proces

104 nts in D2O point to the presence of a single diastereoisomer in solution with a very rigid structure.

105 arting materials to give one major triazolic diastereoisomer in the ratio 74:12:4:10 (dr 84:16, 90% e

106 plates gave (-)-ADMJ and (+)-ADANJ as single diastereoisomers in 16% and 24% overall yield, respectiv

107 tetracyclic products were obtained as single diastereoisomers in 78-99% ee upon variation of the term

108 iral copper catalyst gives the four possible diastereoisomers in a 23:27:23:27 ratio, demonstrating m

109 possess three stereogenic centers, as single diastereoisomers in high enantioselectivity (83-99% ee)

110 or the biomimetic synthesis of flavonolignan diastereoisomers in milk thistle is proposed to proceed

111 in the 1 position may be accessed as single diastereoisomers in one operation from the corresponding

112 ave been calculated for a set of 28 pairs of diastereoisomers in order to test the ability of NMR shi

113 s aimed at evaluating the potential of these diastereoisomers in the prevention and treatment of estr

114 orresponding amino acid derivatives as major diastereoisomers in yields ranging from 37% to 70% with

115 ly, chromatographic separation of individual diastereoisomers is limited to oligonucleotides that con

116 centers in high optical purity and as single diastereoisomers is now reported.

117 renes, one cis-1 and two unprecedented cis-2 diastereoisomers, is reported.

118 tivity on the R(p) and none against the S(p) diastereoisomer, it bound these duplexes in the same coo

119 pidly between LGSH and cysteine, whereas the diastereoisomer L-Lac-Cys is formed directly from MG and

120 The faster eluting diastereoisomer, (-)-lk-9, was revealed to possess an (a

121 Both diastereoisomers not only showed the ability to synthesi

122 methyl acrylate a pathway leading to the two diastereoisomers obtained experimentally is predicted.

123 er of 1 and 2, as for example with the minor diastereoisomer of 1 log(k(d)'/s(-1)) = -4.84 + 0.37pi*

124 The configuration of the main diastereoisomer of 3-methyl-1-xyloside-allene was determ

125 ed oligodeoxynucleotides containing a single diastereoisomer of 4-OHEN-dA (Pk-1, Pk-2, and Pk-3) were

126 1, Pk-2, Pk-3, and Pk-4) containing a single diastereoisomer of 4-OHEN-dC were prepared by a postsynt

127 Compound 11 (BI-97C1), the most potent diastereoisomer of compound 4, inhibits the binding of B

128 miscoding properties varied depending on the diastereoisomer of dG-N2-TAM adducts and the DNA pol use

129 The pure diastereoisomer of known riboside 4 displayed high hA(1)

130 seen in mice that were administered LY-D, a diastereoisomer of LY-411,575, which is a very weak gamm

131 ania major NMT were obtained, and the active diastereoisomer of one of the inhibitors was identified.

132 The enantiomers of the major diastereoisomer of oxa- and azabicyclo[3.2.0]heptane der

133 lectivity for substrates, providing a single diastereoisomer of the product in 80-98% yield.

134 acent chiral centers and leading to a single diastereoisomer of the title compound.

135 ed oligodeoxynucleotides containing a single diastereoisomer of trans or cis forms of dG-N2-TAM were

136 ese methods to distinguish up to 64 possible diastereoisomers of 117 different molecules, using NMR s

137 The diastereoisomers of 26-trans and 26-cis were synthesized

138 The diastereoisomers of 3 were separated via preferential cr

139 en the analysis of the cis- versus the trans-diastereoisomers of 3-methylcyclohexanol (1-cis versus 1

140 the preparation of two sets of (R)- and (S)-diastereoisomers of 5'-C-phenylthymidine ((Ph)T) and 5'-

141 e separation and characterization of the two diastereoisomers of [Ru(phbpy)(phen)(MeSO(C(7)H(7)))]PF(

142 tate superstructures from two conformational diastereoisomers of a homochiral macrocycle is a rare, i

143 alysis, which can resolve the trans- and cis-diastereoisomers of alpha-(N(2)-deoxyguanosinyl)TAM (dG-

144 The route has also been used to prepare two diastereoisomers of anamarine in 14 steps.

145 ep, stereoselective synthesis of each of the diastereoisomers of C30 botryococcene.

146 The diastereoisomers of D-erythroC18-ceramide, D-threo-, and

147 With pol eta, all diastereoisomers of dG-N2-TAM promoted small amounts of

148 ive gramicidin A (gA), and in the SS- and RR-diastereoisomers of dioxolane-linked gA channels (SS and

149 ative gramicidin A (gA) and in the SS and RR diastereoisomers of dioxolane-linked gA channels in plan

150 In each case, and for both diastereoisomers of each probe-protein complex, the hydr

151 A series of diastereoisomers of endomorphin-1 (EM1, Tyr(1)-Pro(2)-Tr

152 y and amenable to scale-up leading to single diastereoisomers of N-Boc and N-Fmoc protected spiroisox

153 ir relative affinities for the (6S) and (6R) diastereoisomers of N5-methyltetrahydrofolate.

154 Site-selective DNA cleavage by diastereoisomers of Ni(II) x Gly-Gly-His-derived metallo

155 diastereoisomer, we generated two alternate diastereoisomers of nonactin, one prepared solely from (

156 te that the enantiomers of ibuprofen and the diastereoisomers of one of its main metabolites, the glu

157 All four possible diastereoisomers of phosphinoferrocenyloxazoline (Phosfe

158 to selectively control the formation of all diastereoisomers of reaction products possessing multipl

159 The syn and anti diastereoisomers of some 1,3,5-triarylisocyanurate deriv

160 tereoselective synthesis of all the possible diastereoisomers of the 2,6-diaryl-3,7-dioxabicyclo[3.3.

161 is-epoxides lead to opposite ( syn and anti) diastereoisomers of the addition products.

162 he key step in the syntheses of all possible diastereoisomers of the homalium alkaloids hoprominol an

163 nt here the first synthesis of the 5R and 5S diastereoisomers of the N-acyl derivatives of 5-hydroxy-

164 al nhatrangins led us to synthesize six more diastereoisomers of the proposed structure of nhatrangin

165 ate, for the first time, the presence of the diastereoisomers of these p-menthane lactones, as well a

166 ing a selective enzyme digestion, one of the diastereoisomers of this compound, (R(p))-E1-3-MTP, coul

167 Several diastereoisomers of unique dC and dA DNA adducts were de

168 the natural (C5'- S) and unnatural (C5'- R) diastereoisomers of uracil polyoxin C methyl ester have

169 d additionally produce separated trans-/cis- diastereoisomers or if both species may interconvert thr

170 containing two equilibrating conformational diastereoisomers, presumably present in unequal molar pr

171 lalanine, the derived deuterium-labeled beta-diastereoisomer product, derivatized as the N-acetyl met

172 PSI-7851 is a mixture of two diastereoisomers, PSI-7976 and PSI-7977, with PSI-7977 b

173 nd 17alpha-(2'R/S)-O-tetrahydropyranyl ether diastereoisomers revealed different combinations of axia

174 o-TolMgBr resulted in a single P-stereogenic diastereoisomer (S(c),S(p),S(phos) and S(c),R(p),R(phos)

175 The nonsteroidal estrogen equol occurs as diastereoisomers, S-(-)equol and R-(+)equol, both of whi

176 These two conformational diastereoisomers self-organize-and self-sort-in the crys

177 g(H)) in native gramicidin A (gA) and in two diastereoisomers (SS and RR) of the dioxolane-linked gA

178 d are needed for the formation of a nonactin diastereoisomer that can act as an ionophore and has ant

179 corresponding piperidine radical as a single diastereoisomer that may either be trapped by tributylti

180 The stereodivergent synthesis includes diastereoisomers that cannot be selectively synthesized

181 o the formation of cyclopentenones as single diastereoisomers that incorporate two contiguous asymmet

182 Notably, the reaction gives trans diastereoisomers that result from an anti-addition acros

183 In the case of racemic diastereoisomers, the two expected enantiomers (atropiso

184 total synthesis of (+)-varitriol and of two diastereoisomers thereof, which represent an unprecedent

185 ective access to either of a syn- or an anti-diastereoisomer through kinetic or thermodynamic epimeri

186 cyclic iminium salts were obtained as single diastereoisomers through an atroposelective oxazolidine

187 wo peptides and enabled the identity of each diastereoisomer to be proposed.

188 ture or that required extensive synthesis of diastereoisomers to establish their stereochemistry.

189 Preliminary application of these four ligand diastereoisomers, together with (S(c),S(p)) and (S(c),R(

190 formation of either the syn,anti or syn,syn diastereoisomers, two of the four possible diastereoisom

191 l, carpanone is accompanied by two carpanone diastereoisomers unknown so far in a 5:1:4 ratio.

192 ight on the exclusive formation of the trans-diastereoisomers via a 4pai-conrotatory electrocyclizati

193 We demonstrated that the iooo diastereoisomer was able to function as a multitopic rec

194 Each single diastereoisomer was isolated and fully characterized.

195 The exo diastereoisomer was obtained exclusively for the latter,

196 the natural product (+)-varitriol and of two diastereoisomers was acomplished.

197 ct prevailing, and the configuration of both diastereoisomers was corroborated by single crystal X-ra

198 origins of selectivity between cis and trans diastereoisomers was gained, highlighting the importance

199 achiral nonactin is the naturally generated diastereoisomer, we generated two alternate diastereoiso

200 Both non-natural diastereoisomers were 500-fold less active against gram

201 ture, and the biological activity of several diastereoisomers were accomplished by our group in 2007

202 Two diastereoisomers were formed in a ratio of 63/35 with th

203 The alternative diastereoisomers were formed selectively by addition of

204 These diastereoisomers were found to be selective and efficien

205 or the inactivity and reduced potency of the diastereoisomers were investigated using NMR spectroscop

206 h applies to the case of assigning a pair of diastereoisomers when one has both experimental data set

207 nondesensitizing (type II) PAMs are cis-cis-diastereoisomers, whereas all of the NAMs, SAMs, and typ

208 complex [Ru(6a)(PNNP)](2+) (7a) as a single diastereoisomer, which contains the unsaturated beta-ket

209 n to reside in only one of the four possible diastereoisomers, which exhibited a perfect match with k

210 stitution in DBPP moieties affords a pair of diastereoisomers whose rotational isomerization has been

211 W 188 compound as a 2-hydroxyterpenylic acid diastereoisomer with 2R,3R configuration.

212 ction proceeds through formation of a single diastereoisomer with high stereoselectivity.

213 chanism, we synthesized a pair of deuterated diastereoisomers with a chiral center at the benzylic po

214 ontrolled elimination reaction of one of the diastereoisomers with DBU, followed by hydrogenation, ga

215 Modular access to two different diastereoisomers with high enantioselectivities was obta

216 functionalized aziridine products as single diastereoisomers with retention of configuration at the

217 roduce stable heteroaromatic atropisomers or diastereoisomers, with one or two N-Csp2 stereogenic axe

218 step in the synthesis generated a couple of diastereoisomers, with only one able to act as a FGF tra