ライフサイエンスコーパス: diastereomeric

1 These adducts were directly converted to the diastereomeric 2,4,5-trisubstituted piperidines syn-5m,

2 ve configurations for the complete set of 16 diastereomeric 2-(2-ethyl-1,3-dioxolan-2-yl)-7-hydroxy-3

3 to assign the relative configurations of 13 diastereomeric 2-(2-ethyl-1,3-dioxolan-2-yl)-7-hydroxy-3

4 A series of diastereomeric 2-(2-pyrrolidinyl)-1,4-benzodioxanes bear

5 Electrophilic quench of the resolved diastereomeric 2-lithiopyrrolidine-chiral ligand complex

6 The regiodivergent ring contraction of diastereomeric 2-silyl-5,6-dihydro-6-aryl-(2H)-pyrans vi

7 ,4-dimethyl-5-ketohexanoic acid (3a) and the diastereomeric (2S,4S)-3b.

8 THF at -78 degrees C, affording a series of diastereomeric 3-aminoindan-1-ones via a novel rearrange

9 In the case of diastereomeric (3RS,4RS)- and (3RS,4SR)-N-Boc-3-amino-2-

10 yzed and the pH-independent reactions of two diastereomeric 6-methoxy-trans-1,2,3,4,4a,10a-hexahydrop

11 l basis for this difference, the HNE-derived diastereomeric (6S,8R,11S) and (6R,8S,11R) cyclic hemiac

12 Diastereomeric 8,5'-cyclopurine 2'-deoxynucleosides, con

13 lic [5.3.1] and [4.3.1] ring systems in high diastereomeric (97-99% de) and enantiomeric purity.

14 obtained via a stereodivergent resolution to diastereomeric acetals.

15 ,1-dichlorocyclopentane yielded a mixture of diastereomeric activation products.

16 Diastereomeric acylation transition state models are pro

17 de to advanced aldehyde 51 afforded a single diastereomeric adduct 53 which is tentatively assigned t

18 Diastereomeric adduct pairs were separated and character

19 Diastereomeric adducts comprising an enantiomerically pu

20 ormed in the photoaddition, namely, the four diastereomeric adducts to the C1-C2 and C5-C6 bonds of t

21 ework that lead to energetically more stable diastereomeric adducts.

22 rivatives, namely, the spirocyclic ketone 6, diastereomeric alcohols 7 and isomeric diols 8.

23 mizations of the duplexes containing the two diastereomeric aldehydes predicted that the (6S,8R,11S)

24 tals, the conformations of the corresponding diastereomeric aldehydes were predicted, using molecular

25 lectivity is set during the formation of the diastereomeric alkoxyphosphonium salts (DAPS), such that

26 The ratio of diastereomeric allenes varies depending on the substitut

27 dative addition step to form the more stable diastereomeric allyl complex leads to the high enantiose

28 attack to the rates of epimerization of the diastereomeric allyliridium complexes containing a weakl

29 ization of the less thermodynamically stable diastereomeric allyliridium complexes to the thermodynam

30 ulation was evaluated and enhanced utilizing diastereomeric allylsilanes anti-5 and syn-5 to establis

31 ysis' relies on the fact that the protons in diastereomeric alpha-methoxy-alpha-trifluoromethylphenyl

32 Analyses of the meteorite diastereomeric amino acids alloisoleucine and isoleucine

33 mposition and abundances, in particular some diastereomeric amino acids may gauge its extent by the c

34 ctive formation of only one of four possible diastereomeric aminopalladation products of the chiral P

35 esis, which delivered 1872 compounds in high diastereomeric and chemical purity.

36 oss-coupling generated product mixtures with diastereomeric and enantiomeric ratios close to unity.

37 course of this study, a strong self-induced diastereomeric anisochronism (SIDA) phenomenon was obser

38 e also provides efficient access to all four diastereomeric arrangements of the core stereotriad of t

39 threonine stereoisomers are converted to the diastereomeric aza-threonines by mesylation, azide displ

40 ctive anti-PAH monoclonal antibody with four diastereomeric benzo[a]pyrene tetrols (BPTs) is studied

41 ate then forms from the resulting mixture of diastereomeric borates as a result of differential solub

42 3-phenyldiboronic acid to afford mixtures of diastereomeric boronate esters whose homochiral/heteroch

43 1, an antiulcer drug, were synthesized from diastereomeric building blocks (-)-5a and (+)-5b.

44 Synthesis and characterization of two diastereomeric C-shaped molecules containing cofacial th

45 resented suggesting that the origin of these diastereomeric C3'(S) and C3'(R) derivatives of 1-thymin

46 ugate base of adenine or thymine to give two diastereomeric C3'(S) and C3'(R) derivatives of 1-thymin

47 s); temperature-dependent equilibria between diastereomeric cages are also quantified.

48 An 11-step synthesis is described of two diastereomeric candidates for a bis(acetylenic) enol eth

49 ctive total synthesis of the two most likely diastereomeric candidates for the structure of 5 solidif

50 crocyclic amine, which contains two types of diastereomeric cations differing in terms of inverted tw

51 An unusual diastereomeric CB[6] with a Mobius geometry (13) is prop

52 us making it plausible that a panel of eight diastereomeric chagosensine-like compounds would allow t

53 those obtained in dichloromethane using the diastereomeric chiral cationic dirhodium(II,III) carboxa

54 proteins stereospecifically convert distinct diastereomeric chiral isoflavonoid precursors to the chi

55 A new series of customizable diastereomeric cis- and trans-monocyclic enol-phosphonat

56 The diastereomeric complex will favor either P or M helicity

57 Following its resolution by diastereomeric complexation, 5,5',6,6'-tetrahydroxy-3,3,

58 influence of environment on the formation of diastereomeric complexes and variations among them.

59 In this study, the formation of diastereomeric complexes by coadsorbed methyl 3,3,3-trif

60 le step and combines practical resolution of diastereomeric complexes due to signal sharpness and eff

61 ielding unique coordinates for the generated diastereomeric complexes is assessed.

62 e of the chemical shifts (Deltadelta) in the diastereomeric complexes is comparable with other, well-

63 Isolation and X-ray characterization of both diastereomeric complexes, as well as an examination of t

64 amine controls the assembly of the resulting diastereomeric complexes, even if this chirality is rela

65 al diols in acetonitrile to form fluorescent diastereomeric complexes.

66 of a thermodynamic preference for one of the diastereomeric complexes.

67 e paired guanine towards BPDE and modify the diastereomeric composition of N(2)-BPDE-dG adducts.

68 pling reaction, resulting in highly emissive diastereomeric compounds that were studied by UV-vis, fl

69 d methyl (Me)- and n-butyl (nBu)-PTEs in two diastereomeric configurations (S (p) and R (p)) at six d

70 faced tetrahedral cage 1, which exhibits two diastereomeric configurations (T1 and T2) that differ in

71 id, particularly hydroquinine, with complete diastereomeric control and up to 87% enantiomeric contro

72 d showed increased sensitivity compared with diastereomeric controls lacking degradation activity.

73 g natural variants and novel enantiomeric or diastereomeric counterparts.

74 Two diastereomeric crystalline steroid dimers were obtained

75 Both exist primarily as diastereomeric cyclic hemiacetals when placed into duple

76 dyads that promote the formation of unusual diastereomeric cycloadducts.

77 We isolated two of the six possible diastereomeric deep cavitand receptors resulting from th

78 We have polymerized rac-LA using the diastereomeric densely substituted amino acids (2S,3R,4S

79 o separation of enantiomers via formation of diastereomeric derivatives with three stereogenic center

80 Such complexes are diastereomeric, differing in structure and free energy f

81 tereoselectivity in Sharpless asymmetric and diastereomeric dihydroxylation of cis-enynes is disclose

82 the C11-C13 atoms of the target, to provide diastereomeric diketones in 60% or 48% yield (for coupli

83 re prepared by chromatographic separation of diastereomeric dipeptide derivatives formed from N-Boc-L

84 The combination of chiral-NEA driven diastereomeric docking with a tautomeric preference enha

85 ) switching for selection of components of a diastereomeric (E,Z) and enantiomeric (R,S) oxime into a

86 s were screened in one step to determine the diastereomeric/enantiomeric composition of the final pro

87 difference of the hydrogenolysis between two diastereomeric epoxide intermediates shed some light on

88 imerizable pyryliums and the kinetics of the diastereomeric equilibration of these and one other exam

89 s (the set of Delta delta(SR) values) in the diastereomeric esters (or amides), the absolute configur

90 2b was achieved by crystallization of their diastereomeric esters or by kinetic resolution of the ra

91 pecific planar-to-topological communication (diastereomeric excess >95%; the highest asymmetric selec

92 honium salts (DAPS), such that their initial diastereomeric excess (de) limits the final enantiomeric

93 parameters such as enantiomeric excess (ee), diastereomeric excess (de), and yield are becoming incre

94 which were isolated in 80-84% yield and high diastereomeric excess (dr > 97/3) after purification via

95 oughput real-time evaluation of enantiomeric/diastereomeric excess (e.e./d.e.) and product yield of c

96 cellent yields and, in some cases, excellent diastereomeric excess (up to >95%) at 100 degrees C in 8

97 wist is achieved using chiral amino ligands (diastereomeric excess up to 77%, the highest reported to

98 ase, which lacks a cavity, shows much higher diastereomeric excess with the encaged proazaphosphatran

99 More recently, ee and its cousin de (diastereomeric excess) have been used (inappropriately)

100 rally good to excellent yield with very high diastereomeric excess) or cis isomer (with yields and di

101 e central-to-planar communication (up to 60% diastereomeric excess).

102 erene in an efficient manner and with a good diastereomeric excess.

103 uction of substituted N-heterocycles in high diastereomeric excesses via stereocontrolled enolate for

104 d crystal, these enantiomeric domains become diastereomeric, exhibiting unexpected and markedly diffe

105 ddition of deoxyguanosine to HNE yields four diastereomeric exocyclic 1,N(2)-dG adducts.

106 -configured [Fe(bisDHBS)](2-) from a pool of diastereomeric Fe(III)-bisDHBS species that includes com

107 These studies indicate, inter alia, that one diastereomeric form of the complexes cis-[Pt(NH3)2(Am)(R

108 The major diastereomeric form of the product is determined by the

109 70-96% yield and 92:8 to >98:2 dr-in either diastereomeric form-by reactions with alkyl-, aryl-, het

110 re simulated, evidencing the presence of two diastereomeric forms of 4a, and single diastereomers of

111 simple epimers, which when combined produce diastereomeric glycoconjugates indistinguishable by mass

112 function of sulfur dioxide to give a pair of diastereomeric heterocyclic six-membered ring products d

113 These isomerized to diastereomeric hydroxymethylphosphonamidates (phosphate-

114 resubmission experiments establish that the diastereomeric iCB[6] and iCB[7] are kinetic products th

115 in which a rapid tautomeric equilibration of diastereomeric iminium cations is combined with a diaste

116 es in which dynamic kinetic equilibration of diastereomeric iminium ions precedes a stereochemistry-d

117 rom hydrogen isocyanide to imine to generate diastereomeric iminium/cyanide ion pairs that are bound

118 scopic analysis of the resultant mixtures of diastereomeric iminoboronate esters.

119 atives (of unknown chirality) to produce two diastereomeric iminoboronates that differ in their fluor

120 Here we present evidence for strong diastereomeric interaction effects at the mesoscale, man

121 use of the fluorescence technique to measure diastereomeric interactions between both enantiomeric fo

122 The results show that diastereomeric interactions between NEA and MP occur pre

123 al IL to solubilize an analyte and to induce diastereomeric interactions for the determination of ena

124 iral RTIL to solubilize a drug and to induce diastereomeric interactions for the determination of ena

125 Diastereomeric interactions in 2D crystals formed at sol

126 ith the relative stability and reactivity of diastereomeric intermediates downstream in the catalytic

127 The diastereomeric intermediates were separated by chiral co

128 0 steps and a preparative HPLC separation of diastereomeric intermediates.

129 onstrating geometric differences between the diastereomeric intermolecular complexes.

130 The latter forms diastereomeric interstrand N(2)-dG:N(2)-dG cross-links i

131 The symmetric pathways give diastereomeric isomers.

132 Three pairs of cis versus trans diastereomeric lactones were used to assess the ability

133 Using a pair of diastereomeric ligands that have essentially identical c

134 Unique perylene diastereomeric linear and cyclic dimers were synthesized

135 ron-donor - electron-acceptor interaction of diastereomeric macrocycles, leading to structurally dist

136 rate flexibility, enabling the production of diastereomeric macrolactones.

137 tion of a racemic cyclitol derivative as its diastereomeric mandelate esters are the key steps in the

138 With diastereomeric metal complexes that undergo rapid interc

139 reomers between them and with respect to the diastereomeric mixture (3S,4S) + (3S,4R).

140 The single diastereomer 51 of diastereomeric mixture 14 was crystallized, and an X-ray

141 g, the reaction proceeds with formation of a diastereomeric mixture [compounds 6 and 7 in 70:30 ratio

142 r in 32% yield and with dr = 98:2 from a 1:1 diastereomeric mixture after crystallization.

143 face of the 1,3-dipole, with formation of a diastereomeric mixture in 73:15 ratio.

144 reaction, and (3) ring-opening reaction of a diastereomeric mixture of a diaminolactone to synthesize

145 asymmetric allylic alkylation reaction of a diastereomeric mixture of allylic carbonates that is ena

146 Base-mediated cyclocondensation of a diastereomeric mixture of aminophosphonates II leads exc

147 We demonstrate that the N-amidification of a diastereomeric mixture of CF3-PsiPro using Fmoc-protecte

148 The diastereomeric mixture of d/l-2,7-diaminooctanedioyl-bis

149 hat combines chiral liquid chromatography, a diastereomeric mixture of isotopically labeled internal

150 ene [generated from (CF3)2Hg and NaI] gave a diastereomeric mixture of the 3',4'-difluoromethylene co

151 eCp(CO)(3), 1, the olefin was converted to a diastereomeric mixture of the C(8)-dimer tricyclohexadec

152 +) ([Ru] = Cp(PPh3)2Ru) in CHCl3 generates a diastereomeric mixture of the substituted tetrahydropyra

153 mbers written within parentheses represent a diastereomeric mixture or racemate; compound numbers wit

154 The dimeric peptide 1 (BVD-74D, as a diastereomeric mixture) is a potent and selective neurop

155 Y and CrISY, the cyclization step produces a diastereomeric mixture.

156 en within brackets represent a racemate or a diastereomeric mixture; compound numbers without bracket

157 9a-e, 11a-d; LLL-tripeptides 18a-c, 20; and diastereomeric mixtures (9b+9b'), (9c+9c'), (11b+11b') a

158 erization was found to be pH dependent, with diastereomeric mixtures formed on condensation.

159 of nitroepoxides to chiral amines to afford diastereomeric mixtures of aminoimines and subsequent st

160 or ethyl iodide and potassium carbonate gave diastereomeric mixtures of N-alkyl derivatives, and the

161 bene (generated from PhHgCF(3) and NaI) gave diastereomeric mixtures of the 2,2-difluorospirocyclopro

162 Diastereomeric mixtures of thymidine glycol and the corr

163 nd numbers written within brackets represent diastereomeric mixtures or racemates; compound numbers w

164 After significant investigation, the diastereomeric molecule with the C11 and C13 configurati

165 the separable FAPY bases and nucleosides are diastereomeric N5 formyl derivatives involving axial asy

166 iary by H(2) (Pd/C) gave the four individual diastereomeric nucleotides 12, which were characterized

167 es, which complex Fe(II) to form a series of diastereomeric octahedral complexes that are CD-active i

168 ns, thereby validating the function of these diastereomeric oligonucleotides as prodrugs in vitro.

169 ifferent stereoinduction levels for designed diastereomeric organocatalysts.

170 -concept application in organocatalysis, the diastereomeric P-chiral beta-aminophosphine-based bifunc

171 les quantification of the er values for each diastereomeric pair by CD analysis.

172 manner, the enantiomeric ratio of the other diastereomeric pair decreases.

173 and L-threonine and to the preparation of a diastereomeric pair of N-Fmoc-protected dipeptidyl diazo

174 conformers of betaalphaL and betaalphaD form diastereomeric pairs (A/A', C/C', and G/G') that have ne

175 The diastereomeric pairs 11a/11b and 12a/12b were separated

176 e system undergoes isomerization, one of the diastereomeric pairs drifts spontaneously to a higher en

177 eoxyinosine, by the amino triol then yielded diastereomeric pairs of diol epoxide-adducted 2'-deoxyad

178 analysis in which the differentiation of the diastereomeric pairs of GSLs could be achieved with offl

179 significant spectral differences between the diastereomeric pairs of GSLs, which permits their distin

180 th differentiation and quantification of the diastereomeric pairs of GSLs.

181 allows for the relative quantitation of the diastereomeric pairs without all standards.

182 ity functional theoretical investigations of diastereomeric phenanthriplatin analogs in order to prob

183 f the P-chiral center of the undesired (R,R)-diastereomeric phosphine oxide 19 through chlorination f

184 ic products with complete consumption of the diastereomeric precorsors or their mixtures.

185 ubstrates without an ortho-methyl group, the diastereomeric precursors interconvert slowly at ambient

186 tution patterns control the connectivity and diastereomeric preference found in the products.

187 THF afforded exclusively (E)-1 as the other diastereomeric product and was mediated by a beneficial

188 affords a statistical 3:1 (anti,syn:syn,syn) diastereomeric product ratio.

189 limination is rate-determining for the major diastereomeric product, while the Cu(I) migration step i

190 computer simulation of the formation of the diastereomeric products as a function of time; for sever

191 1o in a site-selective manner to deliver the diastereomeric products of C-allylation syn-4m, -4n, -4o

192 itum generate either one or the other of two diastereomeric products with complete consumption of the

193 efficiency of the DKR (the ratio of the two diastereomeric products) is determined by the balance be

194 xample, (E)- and (Z)-3, cleanly give rise to diastereomeric products, and thus the rhodium-catalyzed

195 cyclization, which resulted in a mixture of diastereomeric products.

196 addition to afford a statistical mixture of diastereomeric products.

197 strates, as exemplified by alkylation of the diastereomeric pseudoephedrine alpha-methylbutyramides,

198 featuring contiguous stereocenters in a high diastereomeric purity after chromatography.

199 Detailed analysis showed that the diastereomeric purity of the target molecule was >91 %,

200 arget compounds in up to 95% yield with >95% diastereomeric purity.

201 nd accurate determination of N-sulfinylamine diastereomeric purity.

202 on of nonracemic samples of [7]helquat 2 via diastereomeric (R,R)-dibenzoyltartrate salts is describe

203 th excellent levels of diastereoselectivity (diastereomeric ratio > 20:1).

204 High diastereoselectivities (diastereomeric ratio > 98:2) and enantioselectivities (e

205 d yield, excellent purity (>95%), and a high diastereomeric ratio (>50:1).

206 arent nitroalkenes (60-87%), and with a high diastereomeric ratio (90:10 to mostly >95:5).

207 The diastereomeric ratio (dr) of the assembly was correlated

208 nters within a single chiral molecule to the diastereomeric ratio (dr).

209 e obtained in up to 83 per cent yield, >98:2 diastereomeric ratio (for allyl additions) and 99:1 enan

210 ituted allenes were achieved with up to 42:1 diastereomeric ratio and 94:6 enantiomeric ratio (up to

211 ld and in up to >98 % SN 2':SN 2 ratio, 96:4 diastereomeric ratio and 98:2 enantiomeric ratio.

212 c-8DL, subject to tuning by variation of the diastereomeric ratio and structure of the 8DL monomers.

213 rvations, and the factors that determine the diastereomeric ratio are discussed.

214 acid derivatives to afford the products in a diastereomeric ratio as good as 93:7, with the major iso

215 stereomeric sulfiniminoboronate esters whose diastereomeric ratio is an accurate reflection of the en

216 Products were formed consistently with a diastereomeric ratio larger than 95:5 in favor of the an

217 However, the relatively modest increase in diastereomeric ratio suggests that our substrate-Lewis a

218 ed with that obtained in solution, where the diastereomeric ratio varied as a function of the excited

219 inose in 11% overall yield and >99.5/0.5 dr (diastereomeric ratio).

220 or catalytic cross-coupling), 90:10 to >98:2 diastereomeric ratio, and 85:15-99:1 enantiomeric ratio.

221 tylboron compound, in up to 97% yield, 88:12 diastereomeric ratio, and 94:6 enantiomeric ratio.

222 tereoselectively in high yields (conversion, diastereomeric ratio, and enantiomeric excess).

223 The products are obtained in high yield, diastereomeric ratio, and enantiomeric excess.

224 89% and a approximately 7:1 [S,S(P):S,R(P)] diastereomeric ratio.

225 ed in up to 97 % yield, >98:2 Z/E, and >98:2 diastereomeric ratio.

226 and 5,5,6-trialkyl-l-pipecolic acids of high diastereomeric ratio.

227 propane aldol and a gamma-lactone in a >95:5 diastereomeric ratio.

228 cyclopropane derivative in a high cis/trans diastereomeric ratio.

229 Diastereomeric ratios >20:1 and up to 99% enantiomeric e

230 Typically, diastereomeric ratios (dr) ranged from 5 to 20:1 for the

231 All stereotetrads were obtained in high diastereomeric ratios and yields, and their relative ste

232 Diastereomeric ratios exceeding 1000 can be achieved wit

233 sulfinamide products in good yields and with diastereomeric ratios of up to 99:1.

234 possible diastereoisomers are observed, with diastereomeric ratios ranging from 3:2 to 40:1 when the

235 s have been obtained in very high yields and diastereomeric ratios up to >99:1.

236 hieved in enantiomeric ratios up to 99:1 and diastereomeric ratios up to 10:1.

237 bioactive compounds, in yields up to 88% and diastereomeric ratios up to 12:1.

238 constitutional isomers in 48-80% yields and diastereomeric ratios up to 5.6:1.

239 s proceeded with at best modest selectivity (diastereomeric ratios up to 66:34 and 72:28, respectivel

240 odimer 4 as the major product in ca. 9.6:0.4 diastereomeric ratios with conversions >95%.

241 uranone can be obtained in good yields, high diastereomeric ratios, and excellent enantiomeric excess

242 he reluctant anti adducts in high yields and diastereomeric ratios, which can be isolated and further

243 tituted benzopyrrolizidinones with excellent diastereomeric ratios.

244 c alcohols with high enantiomeric ratios and diastereomeric ratios.

245 ), enantioselectivities of 76-94%, and >20:1 diastereomeric ratios.

246 sulfones 8, 9, 14, and 16 in high yields and diastereomeric ratios.

247 in agreement with the observed experimental diastereomeric ratios.

248 products from enol carbamate with excellent diastereomeric ratios.

249 ion-paired 1:1 complexes formed between the diastereomeric receptors and organic chloride salts were

250 ,7-dimethoxy-3,4-dihydroisoquinoline to form diastereomeric Reissert compounds 8-11 and 18-21, respec

251 Reactions of the anions of diastereomeric Reissert compounds, either as mixtures or

252 propagating step and a kinetically preferred diastereomeric relationship between a given chirality at

253 es gave rise to pairs of aminotetralins in a diastereomeric relationship.

254 that can be further exploited to improve the diastereomeric resolution when utilizing a drift gas wit

255 he following: (i) preparation of each of the diastereomeric S- and R-MTPA esters and (ii) comparative

256 The diastereomeric (S)-ester leads to the formation of dimer

257 A pair of diastereomeric salen cavitands and their uranyl complexe

258 fication via the dibenzoyl-(L)-tartaric acid diastereomeric salt 16 enriched the ee and de to 100%.

259 ective precipitation of a single form of the diastereomeric salt [TpW(NO)(PMe3)(DMBH)](DBTH).

260 Optical resolution was accomplished via diastereomeric salt formation or alternatively via chrom

261 Diastereomeric salts of racemic acids (RS)-1 and (RS)-2

262 ay diffraction analysis was performed on the diastereomeric salts of roof-shape amines and both isome

263 )-alpha-phenylethylamine was used, and their diastereomeric salts were investigated by (1)H and (19)F

264 the spectra are ascribed to the formation of diastereomeric salts.

265 the quasiracemic mixture provided two quasi-diastereomeric samples, which were demixed and detagged

266 l decomposition of the DAPS shows consistent diastereomeric self-enrichment, indicating a higher rate

267 A resolution strategy based on diastereomeric separation by substitution of the dichlor

268 as substituted with a chiral amine, allowing diastereomeric separation, and the chiral forms were mon

269 While further development of 3b is ongoing, diastereomeric separation, as well as improvements in po

270 lations that produce structures in divergent diastereomeric series possessing the critical vicinal al

271 to predict the er of the enantiomers in each diastereomeric set, along with the dr of the stereoisome

272 onstants, and stereochemical features of the diastereomeric solvates.

273 The major, thermodynamically preferred diastereomeric (-)-sparteine-complexed lithated phosphin

274 d tumor-to-background ratio results for both diastereomeric species predict that both are effective f

275 The diastereomeric spiroiminodihydantoin-2'-deoxyribonucleos

276 Interconversion of the diastereomeric starting esters of (S,R)-12a and (R,R)-12

277 s exhibit unusual behavior, in that all four diastereomeric states can interconvert solely photochemi

278 ermore, X-ray crystal structures of all four diastereomeric states of two of these new motors were ob

279 ed by the supramolecular system to different diastereomeric states that have opposite chiroptical abs

280 The methods described were assayed on four diastereomeric stereodiads and on their parent epoxide.

281 and 16 enables access to all eight possible diastereomeric stereotetrads, seven of which are commonl

282 NMR shift calculation to distinguish between diastereomeric structures.

283 nantiopure pinanediol to afford a mixture of diastereomeric sulfiniminoboronate esters whose diastere

284 permits the prediction of the Xe spectrum of diastereomeric systems in solutions containing Llr, Rlr,

285 d-glucose, resulted in the formation of two diastereomeric tetraols in each case.

286 eveloped an MD-based method for studying the diastereomeric transition state complexes and rationaliz

287 sulfur center in the ylide intermediate, two diastereomeric transition states (endo-TS1 and exo-TS1)

288 vities using computed Gibbs free energies of diastereomeric transition states are in fair agreement w

289 of competing 1,3-diaxial interactions in the diastereomeric transition states for trapping on the alp

290 he reaction was subsequently attempted, with diastereomeric transition states identified for the turn

291 erefore the difference in energy between the diastereomeric transition states of the two enantiomers.

292 al 1,2-bidentate additives and comparing the diastereomeric transition states stemming from the two h

293 Two diastereomeric transition states with orthogonal and ske

294 rily from differences in hydrogen bonding in diastereomeric transition states.

295 ergy difference between the rate-determining diastereomeric transition structures involved in the mos

296 e., the bis-methylated diamine (+)-5 and two diastereomeric tricyclic analogs, were evaluated as pote

297 derived from in situ decarboxylation of the diastereomeric tricyclic beta-lactone.

298 nerated multicomponent assembly that creates diastereomeric tris(pyridine) metal complexes incorporat

299 98 (as shown in Scheme 19 in the article) to diastereomeric vannusal B structure (+)-d-2 (as shown in

300 took us through the total synthesis of eight diastereomeric vannusal B structures [2, d-2, 3, d-3, 4,