ライフサイエンスコーパス: diastereoselective

1 groups four carbon atoms away can be highly diastereoselective.

2 via oxidation of a beta-silyl enone, and (2) diastereoselective 1,3-diketone reduction to form a syn-

3 A regio- and diastereoselective 1,3-dipolar cycloaddition of 2 H-azir

4 We report the first enantio- and diastereoselective 1,4-addition of butenolides to chromo

5 we describe the development of a regio- and diastereoselective 1,4-aminothiolation of 1,3-dienes wit

6 The highly diastereoselective 1,4-conjugate additions of several ni

7 We have developed a Rh(III)-catalyzed diastereoselective [2+1] annulation onto allylic alcohol

8 demonstrated via Lewis acid catalyzed highly diastereoselective (3 + 2) cycloaddition reactions of th

9 g a mild alkylzinc halide reagent; and (3) a diastereoselective [3+2]-cycloaddition to assemble the p

10 rephedrine as a ligand to promote the highly diastereoselective (32:1) propargylation.

11 A highly regio- and diastereoselective (4 + 2)-cycloannulation process of in

12 yrenes in phosphorous acid to facilitate the diastereoselective [4 + 1]-cycloaddition of indoles in c

13 e discussed considering mechanisms involving diastereoselective addition of alkynylcopper complex for

14 A quinidine-catalyzed diastereoselective addition of alpha-angelica lactone to

15 rs of this class of alkaloids exploiting the diastereoselective addition of an axially chiral lithiat

16 res a powerful photochemical opening step, a diastereoselective addition of an ethyl cuprate and an u

17 ted 3-hydroxyoxindole by DBU-mediated highly diastereoselective addition of aryl acetonitrile to N-pr

18 The diastereoselective addition of organozinc species to 1,2

19 anocopper intermediates and their subsequent diastereoselective addition to ketones, allowing for the

20 tions are feasible, and notable examples are diastereoselective additions to aldehydes/aldimines to a

21 This reaction was highly diastereoselective affording a single diastereomer of sp

22 l adducts subsequently undergo base-promoted diastereoselective aldol cascade reactions resulting in

23 thetic approach also features an early-stage diastereoselective aldol reaction to assemble the substi

24 e to construct the C5-C11 polyol fragment, a diastereoselective aldol reaction to control the stereog

25 The protocol entails a highly diastereoselective aldol/Brook rearrangement/cyclization

26 enic fragments were coupled using a 1,5-anti diastereoselective aldolization followed by a 1,3-anti r

27 nvolves two C-C bond-forming steps, a highly diastereoselective alkene hydration, and asymmetric keto

28 ling to form the quaternary C4 stereocenter, diastereoselective alkene reduction to establish the tra

29 Herein, we present a directed enantio- and diastereoselective alkylation of aldehydes with simple o

30 he key stereodifferentiating step involves a diastereoselective alkylation of an alpha-monosubstitute

31 ituted gamma-sultam alpha-carbanions undergo diastereoselective alkylation reactions with alkyl halid

32 5a-i supports previous conclusions that the diastereoselective alkylation step proceeds via an alpha

33 col for performing chromium-catalyzed highly diastereoselective alkylations of arylmagnesium halides

34 nyl compounds, these reagents undergo highly diastereoselective allylations to afford the desired 1,3

35 zation, a 1,3-syn aldolization, enantio- and diastereoselective allylations, a hemiacetalization/oxa-

36 st to provide a rare example of a regio- and diastereoselective allylic substitution in the absence o

37 ackbone of uridine, facilitates a switchable diastereoselective alpha- or beta-C4'/C5'-spirocycloprop

38 Reported herein are diastereoselective and enantioselective allylic substitu

39 was realized by the development of a highly diastereoselective and enantioselective C-C bond-forming

40 catalysts to achieve highly site-selective, diastereoselective and enantioselective C-H functionaliz

41 Both diastereoselective and enantioselective catalytic method

42 in a highly chemoselective, regioselective, diastereoselective and enantioselective fashion.

43 e starting oxindoles allowed a site-specific diastereoselective and enantioselective transformation.

44 This novel route features several remarkably diastereoselective and high-yielding transformations, in

45 Reported herein are the first diastereoselective and Lewis acid-mediated radical react

46 e identified high-yielding protocol is mild, diastereoselective, and catalytic.

47 boration of 1,3-enynes is site-, regio-, and diastereoselective, and is uniquely enabled by the 1,4-a

48 The first highly enantioselective, diastereoselective, and regioselective [2,3]-rearrangeme

49 loying a divergent approach that relies on a diastereoselective anionic oxy-Cope rearrangement to set

50 A diversity-oriented access to diastereoselective arylidene 2,5-diketopiperazines is el

51 One ligand exhibits a highly diastereoselective assembly into homochiral (either Delt

52 boron, and imines allows regio-, chemo-, and diastereoselective assembly of branched alpha,beta-subst

53 nplanar helical conformations leading to the diastereoselective assembly of chiral bis-tridentate mon

54 three-component process for high trans,trans-diastereoselective assembly of five-membered (1-haloviny

55 (R)-alpha-methylbenzylamine, giving a highly diastereoselective asymmetric Mannich-type addition with

56 A diastereoselective auxiliary-mediated vinylation/[1,2]-B

57 resulting from the water-mediated reversible diastereoselective B-O bond cleavage/reformation of the

58 The highly diastereoselective base-promoted intramolecular cyclizat

59 nsformations enabling the approach include a diastereoselective borylative enyne cyclization and a la

60 via regioselective epoxide-ring opening and diastereoselective bromoetherification.

61 riety of indole analogues and thiophenol for diastereoselective C-C, C-N, and C-S bond-forming reacti

62 lylations and functionalizations, as well as diastereoselective C-H silylations of a chiral, natural-

63 A method for the diastereoselective carboboration of 1,2-disubstituted st

64 A highly diastereoselective carbon-carbon bond-forming reaction i

65 ylsiletanes are capable of highly chemo- and diastereoselective carbonyl allylsilylations.

66 Lewis acid-controlled, diastereoselective cationic oxycyclizations enabled asym

67 quentially, a Noyori asymmetric reduction, a diastereoselective chelate- or directed reduction of a b

68 iperazinoindolines proceeds via a regio- and diastereoselective Conia-ene reaction.

69 A method for the site-selective and diastereoselective conjugate addition of boron-stabilize

70 +)-preussin B have been developed, using the diastereoselective conjugate addition of lithium (S)-N-b

71 ino-alpha,beta-unsaturated ester, and doubly diastereoselective conjugate addition of the antipodes o

72 A regio- and diastereoselective conjugate addition of the lithium ani

73 ne alkaloids (T1-T8) were achieved using the diastereoselective conjugate additions of lithium amide

74 ophilic partners for the direct enantio- and diastereoselective construction of beta-fluoroamine moti

75 ophilic partners for the direct enantio- and diastereoselective construction of quaternary carbon ste

76 ioselectivities (up to 95% ee), and complete diastereoselective control in a single-pot operation.

77 med in a single vessel, involving regio- and diastereoselective copper-catalyzed carbomagnesiation of

78 A highly enantio- and diastereoselective copper-catalyzed three-component coup

79 An efficient, enantio- and diastereoselective, copper-catalyzed coupling of imines,

80 pate with catharanthine in the BAHA-mediated diastereoselective coupling reaction and simplified indo

81 ve organocatalytic oxidation of an aldehyde, diastereoselective Cu(OTf)2-catalyzed Michael reaction/t

82 This is because diastereoselective Cu-H elimination may be avoided and/o

83 Subsequent phenylselenonium ion induced diastereoselective cyclization of the drimene completed

84 ttractively functionalized cyclopropanol and diastereoselective cyclization of the resulting aminoall

85 irectly from thymidine, via butenylation and diastereoselective cyclization promoted by N,N-dimethyl-

86 An unexpected diastereoselective cyclization reaction was observed, le

87 cyclization catalyzed by PS-BEMP, and (ii) a diastereoselective cyclization, which formally constitut

88 We first establish highly diastereoselective cycloisomerizations using an achiral

89 C-H insertion and catalyse the enantio- and diastereoselective cyclopropanation of unactivated olefi

90 The diastereoselective cyclopropanation of various alkenes w

91 efin coupling partners leading to a directed diastereoselective cyclopropanation reaction, providing

92 The reaction is highly diastereoselective depending on the homoallylic amine us

93 microsolvation-controlled choices of highly diastereoselective derivatizations of 1.

94 Catalytic tandem diastereoselective desymmetrization of cyclohexadienone-

95 t time to probe the configuration and highly diastereoselective deuteration of a chiral organosamariu

96 f allahabadolactone A is described employing diastereoselective Diels-Alder and selenocyclization rea

97 that undergo a second, substrate-controlled diastereoselective Diels-Alder reaction with a different

98 ate in situ chiral 1,2-DHPs, followed by the diastereoselective Diels-Alder reaction with N-aryl male

99 ium, react with electrophiles to achieve the diastereoselective difunctionalization of the strained c

100 A novel, base-catalyzed and highly diastereoselective direct Michael addition-isomerization

101 al C-H functionalization reactions, namely a diastereoselective dirhodium carbene insertion followed

102 termediate 7-oxo-5-enones underwent a highly diastereoselective (dr >/=96:4) acid-catalyzed aza-Micha

103 proach takes advantage of a highly efficient diastereoselective electrophilic fluorination reaction (

104 , and this represents the first example of a diastereoselective enolate hydrogen borrowing alkylation

105 Key steps include a highly diastereoselective enzymatic desymmetrization, substrate

106 Diastereoselective epoxidation and regioselective ring-o

107 ed epoxidation reagent was developed for the diastereoselective epoxidation of one class of stericall

108 ate promoted intramolecular amination, and a diastereoselective epoxidation that simultaneously conve

109 e in a nine-step sequence featuring a highly diastereoselective equatorial alkynylation and Cu(I) cat

110 synthesis was conducted in an asymmetric and diastereoselective fashion with respect to the imbedded

111 tetracyclic core of the natural product in a diastereoselective fashion.

112 collection of substituted cyclohexanes in a diastereoselective fashion.

113 The key steps include a unique highly diastereoselective FeCl(3).6H(2)O/NaBH(4) reduction of a

114 n the presence of pyridine may be made fully diastereoselective for the trans-N-chloroformylimidazoli

115 trates as a key step leads to the regio- and diastereoselective formation of 1,2-dihydroazocino[4,3-b

116 ta-lactams were deployed as synthons for the diastereoselective formation of chiral 2-(2,2,2-trifluor

117 preferences as well as the mechanism for the diastereoselective formation of specific azabicycloalkan

118 um-(P,olefin) complex-catalyzed enantio- and diastereoselective formation of substituted spiroketals

119 A catalytic, enantio-, and diastereoselective formation of sulfenyl acetals bearing

120 tions provided mechanistic insights into the diastereoselective formation of the 3-spiro-psi-indoxyl

121 in of the allylic group, leading to a highly diastereoselective formation of the product.

122 Our synthesis of caribenol A features the diastereoselective formation of the seven-membered ring

123 The cascade results in a rapid and diastereoselective formation of these scaffolds via desy

124 ation of the indolizine ring was shown to be diastereoselective, forming trans-6b and cis-9.

125 oronic esters and has been applied to highly diastereoselective fragmentation and transannular cycliz

126 ecific halo-Nazarov electrocyclization and a diastereoselective Friedel-Crafts allylation.

127 ylic fluorides followed by hydrogenation and diastereoselective Friedel-Crafts cyclization constitute

128 As a demonstration of product utility, diastereoselective Friedel-Crafts reactions were perform

129 Diastereoselective functionalization processes have also

130 ric aldol reaction using a titanium enolate, diastereoselective Grignard addition to a tert-butanesul

131 A rapid anti-diastereoselective halocyclization of these salts provid

132 erization sequence, undergoes a highly trans-diastereoselective Heck-type coupling reaction with vari

133 Subsequent allylic oxidation and diastereoselective hydride reductions provided the hydro

134 ntioselective enolate alpha-hydroxylation, a diastereoselective hydroboration-oxidation, and a direct

135 t, generally applicable, highly enantio- and diastereoselective hydrogenation of such olefins and the

136 Subsequent diastereoselective hydrogenation provides an additional

137 action, efficient cyclizations, and a highly diastereoselective hydrogenation to assemble multigram q

138 g trans isomer and a coupling, followed by a diastereoselective hydrogenation using Wilkinson's catal

139 In this sequence, fully diastereoselective hydrogeneration of the endocyclic car

140 on the development of a catalytic chemo- and diastereoselective hydrosilylation.

141 The reaction is diastereoselective, in favor of the 1S epimer, when larg

142 ules from a racemic mixture but also imposes diastereoselective incorporation upon achiral molecules.

143 around the cyclopentane ring, namely highly diastereoselective installation of carbo- and heterocycl

144 ormed in an iterative fashion allowing for a diastereoselective installation of two aryl groups along

145 we report a zirconium-catalyzed enantio- and diastereoselective inter/intramolecular double carboalum

146 An advanced protocol for the diastereoselective intramolecular aziridination reaction

147 Chloroacetic acid promotes an efficient and diastereoselective intramolecular cascade reaction of el

148 n with N-allyl-N-(p-tosyl)amine and a highly diastereoselective intramolecular Diels-Alder reaction o

149 Highlights of the approach include a highly diastereoselective, intramolecular Diels-Alder reaction

150 no acid subunits with kinetically controlled diastereoselective introduction of all three elements of

151 ated aglycone delivery method for the highly diastereoselective introduction of the beta-mannosidic l

152 n the first study of a ZnI2-catalyzed highly diastereoselective inverse electron demand hetero-Diels-

153 We present highly regio- and diastereoselective inverse electron demand oxa-Diels-Ald

154 of C20 in steroidal derivatives by a highly diastereoselective Ir-catalyzed isomerization of primary

155 We report a photocatalytic and diastereoselective isomerization of acyclic cinnamyl chl

156 ange of allylic alcohols participates in the diastereoselective isomerization under the optimized rea

157 ve hydroacylation cycle followed by a slower diastereoselective ketone reduction cycle.

158 employs two key strategic cyclizations: 1) a diastereoselective light-mediated cyclization of an O-ar

159 a-amino acids in chiral, nonracemic form via diastereoselective malonate alkylation followed by C- to

160 e access to functionalized cycloadducts in a diastereoselective manner by employing organocatalytic a

161 onstruct cyclobutanes in a highly regio- and diastereoselective manner in solution under visible ligh

162 g 2-arylated hydronaphthylamines in a highly diastereoselective manner is described.

163 ries of highly substituted pyrrolidines in a diastereoselective manner is reported.

164 -disubstituted housane-1-carboxylic acids in diastereoselective manner on up to 80 g scale.

165 -6-oxa-2-azabicyclo[3.2.1]octane in a highly diastereoselective manner through an unexpected intramol

166 e of a catalytic amount of ZnBr2 in a highly diastereoselective manner with excellent yield.

167 struct indoline units in a highly regio- and diastereoselective manner with yields ranging from 63 to

168 eaction gives vinyl sulfones in a regio- and diastereoselective manner, employing sodium sulfinates a

169 o proceed in high yields and in a regio- and diastereoselective manner, giving interlocked 3,4-disubs

170 ntrol, the reaction proceeded in a much less diastereoselective manner.

171 was subjected to nucleophilic addition in a diastereoselective manner.

172 t pyrrolidine units in a highly enantio- and diastereoselective manner.

173 mine-type conduramines were synthesized in a diastereoselective manner.

174 Low temperature NMR studies revealed that a diastereoselective Mannich reaction between a phenyl oxa

175 of selectivity was achieved by using a novel diastereoselective Matteson homologation.

176 putational investigations unveiled a complex diastereoselective mechanism.

177 A diastereoselective mercury(II)-promoted intramolecular c

178 The one-pot regioselective and diastereoselective method for the synthesis of 5-(het)ar

179 A general, scalable two-step regio- and diastereoselective method has been described for the syn

180 ods, are classically made by only moderately diastereoselective methods.

181 r(II) complex-catalyzed enantioselective and diastereoselective Michael reactions of cyclic ketoester

182 In situ silylation and enolization induces diastereoselective migration of the N'-aryl group to the

183 The synthesis highlights the use of a highly diastereoselective Mukaiyama-type [3 + 2]-annulation of

184 Diastereoselective multicomponent reactions of enantioen

185 ture of the dianion (SP,RC)-10 formed in the diastereoselective N,Cortho dilithiation of the phosphin

186 ioselectivity after recrystallization, and a diastereoselective net arylation of the minimally modifi

187 ransformation involves a highly enantio- and diastereoselective NHC-catalyzed dimerization and an ami

188 assembled with trans geometry using a highly diastereoselective Nishiyama cyclopropanation, and the o

189 alyzed malonate desymmetrization, and highly diastereoselective nitrile oxide cycloaddition.

190 hird contiguous stereocenter making use of a diastereoselective nitronate protonation employing alpha

191 ore structure, an unusual intramolecular and diastereoselective Nozaki-Hiyama-Kishi reaction involvin

192 etal complexes to effect chemo-, regio-, and diastereoselective NT.

193 Key steps of synthesis were (i) diastereoselective nucleophilic addition of vinylmagnesi

194 Key steps are a totally diastereoselective nucleophilic addition to the cyclic n

195 rs' chiral hydrazone derivatives followed by diastereoselective nucleophilic addition to the hydrazon

196 The development of a diastereoselective nucleoside phosphorylation is describ

197 Reported herein is a new iron-catalyzed diastereoselective olefin diazidation reaction which occ

198 n-l-sulfoxide[6]uril is prepared in a highly diastereoselective one-pot synthesis from the macrocycle

199 The diastereoselective one-pot synthesis of hexahydrocyclope

200 we conduct carefully orchestrated site- and diastereoselective oxidations and other transformations.

201 In addition, the synthesis utilizes a diastereoselective oxidative dearomatization/cycloadditi

202 the catalytic asymmetric halocyclization and diastereoselective oxyamination reactions of tryptamine

203 The diastereoselective Pd(OAc)2-catalyzed, bidentate ligand-

204 A trans-diastereoselective Pd-catalyzed dearomative [3 + 2] cycl

205 arbon atoms are then installed by means of a diastereoselective Pd-catalyzed decarboxylative allylati

206 d position-specific allylic rearrangement in diastereoselective Pictet-Spengler cyclization were the

207 variety of Lewis acids resulting in a highly diastereoselective Pictet-Spengler cyclization.

208 isoquinoline has been accomplished employing diastereoselective Pictet-Spengler methodology to access

209 Key steps include a diastereoselective Pictet-Spengler reaction and an intra

210 an enantioselective ketone alkylation and a diastereoselective pinacol cyclization.

211 Here we report a diastereoselective polymerization methodology enabled by

212 transformation of the sequence involves the diastereoselective preparation of the desired trifluorom

213 The present study reports regio- and highly diastereoselective preparative methods for the synthesis

214 intermediate is exploited to develop a novel diastereoselective process for the construction of vicin

215 These regio- and diastereoselective processes enable convergent construct

216 tereoselectivity of the enantioselective and diastereoselective processes in aminodialkene cyclizatio

217 ucts all being accessed through these highly diastereoselective processes.

218 stereocenters within a single ligand led to diastereoselective product generation.

219 The catalytic diastereoselective protocol can be extended to aryl, alk

220 s new mode of reactivity was employed in the diastereoselective reaction of arylboron reagents with s

221 Low-yielding and moderately alpha- and diastereoselective reactions are thus turned into highly

222 However, recent diastereoselective reactions reported in the literature

223 The synthesis relies on three highly diastereoselective reactions, including an intramolecula

224 e mainly been used as chiral auxiliaries for diastereoselective reactions.

225 from achiral precursors, which then directs diastereoselective reactions.

226 ls-Alder reaction to construct the C ring, a diastereoselective reduction (under Felkin-Ahn control),

227 e quinolizidine segment, and was prepared by diastereoselective reduction of a pyridine and classic r

228 ficient than those commonly reported for the diastereoselective reduction of five- and six-membered c

229 alpha-Epimerization by oxidation and diastereoselective reduction then gave access to the cor

230 trate-Fe(III) complexes, which shed light on diastereoselective reduction.

231 This protocol uses a robustly diastereoselective reductive amination/aza-Michael react

232 genolytic N-debenzylation was accompanied by diastereoselective reductive cyclization in situ; reduct

233 N-Debenzylation and concomitant diastereoselective reductive cyclization, followed by re

234 amide to tert-butyl 4-phenylbut-2-enoate and diastereoselective reductive cyclizations of gamma-amino

235 ual dichloromethyl substituent, a completely diastereoselective rhodium(II)-catalyzed C-H amination r

236 We have developed a highly regio- and diastereoselective rhodium-catalyzed allylic substitutio

237 nnich-type cyclisation to build ring E and a diastereoselective ring-closing metathesis reaction to c

238 tion of conjugated enyne oxiranes provides a diastereoselective route to (E)-configured 7-hydroxy-2,3

239 We report a concise, enantio- and diastereoselective route to novel nonsymmetrically subst

240 Strategic reductions include a diastereoselective SmI(2)-mediated ketone reduction with

241 dressed with the development of a divergent, diastereoselective strategy for the monoprotodeboration

242 An efficient, mild, and highly diastereoselective strategy for the synthesis of trans-2

243 yrosine derivative (8), the route utilizes a diastereoselective substrate-controlled 1,2-reduction to

244 Many diastereoselective (substrate stereocontrol), and enanti

245 of our concise route is a late-stage, highly diastereoselective, sulfa-Michael addition.

246 we describe a rhodium-catalyzed enantio- and diastereoselective Suzuki-Miyaura cross-coupling between

247 is acid-catalyzed, oxocarbenium ion-mediated diastereoselective syn-allylation reaction, and a methox

248 labeled cyclic enol ethers revealed a highly diastereoselective syn-selective protonation/nucleophile

249 Diastereoselective syntheses of dihydroconduramines (+/-

250 Here, we report the enantio- and diastereoselective synthesis and structure-activity rela

251 The first catalytic enantio- and diastereoselective synthesis of 1,2-hydroxyboronates is

252 We report herein the improved diastereoselective synthesis of 2,5-disubstituted pyrrol

253 A new strategy for the highly enantio- and diastereoselective synthesis of 3,4-dihydrocoumarin deri

254 A diastereoselective synthesis of 4-vinyl oxazolines syn-2

255 Herein, we report the diastereoselective synthesis of a 3-amino-1,2,4-oxadiazi

256 A pot-economic method for the enantio- and diastereoselective synthesis of a [2.2.2] azabicyclic is

257 ss to key intermediates for the enantio- and diastereoselective synthesis of a series of naturally oc

258 t a chiral-squaramide-catalyzed enantio- and diastereoselective synthesis of alpha-allyl amino esters

259 A catalytic protocol for the diastereoselective synthesis of anti-1,2-hydroxyboronate

260 convenient route has been developed for the diastereoselective synthesis of beta-C-glycopyranosyl al

261 le we describe a catalytic procedure for the diastereoselective synthesis of beta-lactones bearing tw

262 alyzed method for the efficient enantio- and diastereoselective synthesis of chiral homoallylic amine

263 The diastereoselective synthesis of cis and trans steroid-fu

264 ternal alkynes can be used in the regio- and diastereoselective synthesis of complex trisubstituted a

265 We report a Rh(III) -catalyzed regio- and diastereoselective synthesis of delta-lactams from readi

266 al addition and cyclization is developed for diastereoselective synthesis of fused-tetrahydrobenzodia

267 The diastereoselective synthesis of highly substituted beta-

268 Further, an enantio- and diastereoselective synthesis of homoallylic amines from

269 A short, diastereoselective synthesis of homocitric acid lactone

270 Extensive study of the diastereoselective synthesis of l-pyranosides utilizing

271 t describes a catalyst-controlled regio- and diastereoselective synthesis of N-unprotected pyrrolidin

272 We report the diastereoselective synthesis of novel spiropiperidine te

273 An efficient diastereoselective synthesis of planar chiral ferrocenes

274 ne containing structures, especially for the diastereoselective synthesis of spiro-pyrrolidines.

275 tes in a new synthesis of anthraquinones and diastereoselective synthesis of tetrahydroanthraquinones

276 e current strategy could be utilized for the diastereoselective synthesis of tetrahydroquinoline deri

277 The method is also used for a highly diastereoselective synthesis of the N-Boc derivative of

278 A concise and highly diastereoselective synthesis of the polyfused tetracycli

279 The process described involves the first diastereoselective synthesis of this type of compound by

280 onditions were identified and applied to the diastereoselective synthesis of unnatural amino acids an

281 A robust diastereoselective synthesis provided sufficient quantit

282 A diastereoselective synthesis was developed to generate (

283 lohelix enantiomer Delta1a, available from a diastereoselective synthesis with no need for resolution

284 y combining chiral HPLC, circular dichroism, diastereoselective synthesis, molecular modeling, and X-

285 interest in developing strategies for their diastereoselective synthesis.

286 Key to the synthesis is a diastereoselective tethered aminohydroxylation of a homo

287 A highly enantioselective and diastereoselective total synthesis of the diterpenoid (-

288 A catalyst-controlled enantio- and diastereoselective total synthesis of the two most likel

289 an be coupled with a crystallization-induced diastereoselective transformation (CIDT) to enhance the

290 cade reactions that couple this enantio- and diastereoselective transformation to additional reversib

291 hemical control elements within the realm of diastereoselective transformations are discussed.

292 l groups present in these compounds, further diastereoselective transformations are easily envisaged

293 the products was illustrated by a number of diastereoselective transformations into reduced tetrahyd

294 Various chemo-, regio-, and diastereoselective transformations of the alpha-tertiary

295 presented including some examples of highly diastereoselective transformations.

296 A diastereoselective two-step strategy for the synthesis o

297 en realized through the enantioselective and diastereoselective umpolung reaction of trifluoromethyl

298 in terms of yields and resulted in a highly diastereoselective unprecedented solvent/catalyst switch

299 Moreover, a diastereoselective variant of this method gives access t

300 chiral 1,3-disubstituted alkoxyallenes in a diastereoselective way.