ライフサイエンスコーパス: diauxic

1 hereas the remaining two models exhibit both diauxic and non-diauxic growth patterns.

2 Our models suggest that the diauxic behavior of cells is the result of the evolution

3 aining the intracellular dynamics underlying diauxic behavior.

4 Lactose metabolism presents both classic diauxic behaviors and long-term memory, where the bacter

5 Pol II processivity is impaired in diauxic cells, but strains with reduced processivity and

6 e find that unlike co-utilizing communities, diauxic community assembly repeatably and spontaneously

7 mycin treatment, and late stages of shift to diauxic conditions and nitrogen depletion suggests that

8 is the only FAA induced during the critical diauxic/early post-diauxic transition.

9 Interestingly, a diauxic effect was observed with sequential consumption

10 In particular, the prediction of diauxic growth corresponds to "extinction" of one of the

11 chia coli and Bacillus subtilis by following diauxic growth curves, assays to estimate the utilizatio

12 two approaches were used in the analysis of diauxic growth in Escherichia coli.

13 Bi-phasic or diauxic growth is often observed when microbes are grown

14 Our results show that classical diauxic growth is only one extreme on a continuum of gro

15 Diauxic growth is usually interpreted as an adaptation t

16 This was reflected by diauxic growth kinetics on medium containing mixed carbo

17 We investigated the diauxic growth of Saccharomyces cerevisiae and demonstra

18 and single gene perturbation phenotypes for diauxic growth on glucose/lactose and glucose/glucose-6-

19 A diauxic growth pattern was obtained when E. coli was gro

20 The Brandt et al. model always predicts the diauxic growth pattern, whereas the remaining two models

21 ning two models exhibit both diauxic and non-diauxic growth patterns.

22 In contrast, under diauxic growth shift conditions, Dhh1 and Pat1 are found

23 of Dhh1 and Pat1 change as cells undergo the diauxic growth shift.

24 Diauxic growth with glucose and lactose was not affected

25 This phenotype exhibits diauxic growth, a manifestation of the winner-take-all d

26 nations of polysaccharides also give rise to diauxic growth, other combinations result in synergistic

27 of substrate consumption patterns including diauxic growth, simultaneous consumption, and bistable g

28 (1) In almost all the cases of diauxic growth, the "preferred" substrate is the one tha

29 nes are inhibited and the bacterium exhibits diauxic growth.

30 ions counting from the beginning of the post-diauxic growth.

31 such systems, especially those resulting in diauxic growth.

32 cose to lactose metabolism without a classic diauxic lag phase.

33 then undergo a transient growth delay, the "diauxic lag," while inducing genes to metabolize the les

34 arger upfront growth cost but also a shorter diauxic lag.

35 yces cerevisiae display short or nonexistent diauxic lags when grown in mixtures of glucose (preferre

36 ere, we develop and study a minimal model of diauxic microbial communities assembling in a serially d

37 present only during the log and diauxic/post-diauxic periods, indicating that N-myristoylproteins pre

38 ed defective aerobic respiration in the post-diauxic phase but retained normal intrinsic mitochondria

39 s post-translationally activated in the post-diauxic phase of growth and that it localizes to mitocho

40 protein levels are increased by H2O2, in the diauxic phase of normal growth conditions, and in cells

41 ogarithmic growth, worsened through the post-diauxic phase, and became extreme in stationary phase.

42 the levels of phytoceramide during the post-diauxic phase, demonstrating that the activation of Isc1

43 C, which resides in mitochondria in the post-diauxic phase, showed defective aerobic respiration in t

44 In the post-diauxic phase, the cooperative effect of the pheromone a

45 ory substrates into mitochondria in the post-diauxic phase.

46 drial respiratory electron transport in post-diauxic-phase cells under conditions of lethal heat shoc

47 is normally present only during the log and diauxic/post-diauxic periods, indicating that N-myristoy

48 Yeast cells undergoing the diauxic response show a striking upstream shift in poly(

49 e found that yeast propagated until the post-diauxic shift (72 h) provided better longevity in the bo

50 athways and the pathways that respond to the diauxic shift (including glycolysis and the citric acid

51 catabolite repression, the aerobic/anaerobic diauxic shift and amino acid biosynthesis pathway repres

52 /3 and SNO2/3 mRNAs are induced prior to the diauxic shift and decrease in abundance during the postd

53 is down-regulated as cells pass through the diauxic shift and enter stationary phase.

54 and between Saccharomyces species during the diauxic shift and found appreciable cis-acting variation

55 omatin structure closes when cells enter the diauxic shift and growth dramatically slows.

56 Puf3p levels are reduced during the diauxic shift and growth on a nonfermentable carbon sour

57 Expression of GTT1 is induced after diauxic shift and remains high throughout the stationary

58 le: cell cycle, DNA damage, stress response, diauxic shift and sporulation.

59 ss of SVF1 is associated with defects in the diauxic shift and the oxidative stress response.

60 show that genes normally induced during the diauxic shift are not properly induced in a ctk1Delta st

61 lysis of expression data from a recent yeast diauxic shift experiment.

62 This method has been validated on diauxic shift experiments and reproduces well known effe

63 metabolic adaptations that occur during the diauxic shift have not been fully characterized at the o

64 e genes failed to be up-regulated across the diauxic shift in a manner similar to the Deltaisc1 strai

65 so is observed, at least in part, during the diauxic shift in batch cultures.

66 ested for the ability to efficiently undergo diauxic shift in the presence and absence of Bcl-x(L).

67 ells, mRNA content was less abundant in post-diauxic shift phase and even less in stationary phase C.

68 transcripts of many genes increased in post-diauxic shift phase as well as stationary phase.

69 xpressed at higher levels at and beyond post-diauxic shift phase.

70 ermentative to a respiratory metabolism, the diauxic shift represents the stage where major structura

71 ible homodimeric protein that is involved in diauxic shift reprogramming and has glyoxalase activity.

72 ociation of the Arc1p:GluRS complex upon the diauxic shift to respiratory conditions.

73 ing through the cell cycle, sporulation, and diauxic shift were analyzed.

74 cerevisiae following glucose depletion (the diauxic shift) depends on a profound metabolic adaptatio

75 transition of log phase to stationary phase (diauxic shift) for effective CLS extension.

76 During nutrient limitation (diauxic shift) or after treatment with rapamycin (a spec

77 carbohydrate in the media becomes limiting (diauxic shift).

78 d, CR increased acetyl-CoA levels during the diauxic shift, along with expression of both acetyl-CoA

79 es: cell cycle, DNA damage, stress response, diauxic shift, and sporulation.

80 etabolic reprogramming that occur during the diauxic shift, and the expression patterns of many previ

81 period of maximal SNF1 activation beyond the diauxic shift, as indicated by Sak1-dependent T210 phosp

82 premature growth arrest of cells during the diauxic shift, as they adapt to the changing environment

83 nteracts with Snf1 and is induced during the diauxic shift, had an inhibitory role on invasive growth

84 direct target genes are also induced by the diauxic shift, in which glucose levels begin to be deple

85 tive to respiratory metabolism, known as the diauxic shift, is reflected by dramatic rearrangements o

86 during log phase and reassembled during the diauxic shift, largely accounting for the differences in

87 the Mot1-repressed genes are involved in the diauxic shift, stress response, mating, or sporulation.

88 izes Snf1 activity throughout and beyond the diauxic shift, thus optimizing the coordination of nucle

89 mentable carbon source metabolism during the diauxic shift, thus suggesting a mechanism for the defec

90 onQ) cells are initiated within hours of the diauxic shift, when cells have scavenged all the glucose

91 3 mutants, SNZ1 mRNA is induced prior to the diauxic shift, when SNZ2/3 mRNAs are normally induced.

92 e possibility that mitochondria may initiate diauxic shift-associated regulation of nucleus-encoded g

93 We describe a previously unknown type of diauxic shift-dependent modulation of the intracellular

94 histone deacetylase complex was required for diauxic shift-induced H4 and H2B deposition onto rDNA ge

95 n of glycogen accumulation that precedes the diauxic shift.

96 er exhausting glucose, generating a reversed diauxic shift.

97 2, two targets of Pdr1, also overgrow at the diauxic shift.

98 agments after rapamycin treatment and during diauxic shift.

99 expression of numerous yeast genes after the diauxic shift.

100 very similar to those in cells undergoing a diauxic shift.

101 the metabolic remodeling associated with the diauxic shift.

102 ells undergo the metabolic transition at the diauxic shift.

103 (Ser(2)) phosphorylation observed during the diauxic shift.

104 atch cultures just before they undergo this "diauxic shift." Essentially the same pattern was found b

105 that the yeast DJ-1 homologs have a role in diauxic-shift (DS), characterized by metabolic reprogram

106 hese genes were found to be clustered in the diauxic-shift experiment as well.

107 Even though diauxic shifts emerge naturally from the model when two

108 can result in biphasic growth curves called "diauxic shifts" that typically arise when microbes are g

109 carbon upshifts and downshifts (for example, diauxic shifts) without adjustable parameters.

110 f the top choice resource to the growth of a diauxic species.

111 alternative polyadenylation (APA) under the diauxic stress.

112 s a trade-off between lost growth during the diauxic switch and the long-term growth potential of the

113 rowth, but causes a significant delay in the diauxic transition from glucose to acetate.

114 The importance of ADR1 during the diauxic transition is illustrated by the observation tha

115 nscription factors are active only after the diauxic transition, when glucose is depleted and energy-

116 duced during the critical diauxic/early post-diauxic transition.