ライフサイエンスコーパス: diazene

1 duction pathway at the level of reduction of diazene.

2 ansposition of the in situ generated allylic diazene.

3 onium salts and reduced to the corresponding diazenes.

4 a-unsaturated aldehydes and various aromatic diazenes.

5 type diamine-Mg(2)(olz) (olz(4-) = (E)-5,5'-(diazene-1,2-diyl)bis(2-oxidobenzoate)) that feature dive

6 nzene dicarboxylic acid (H(2)ABDA) and 4,4'-(diazene-1,2-diyl)bis(3,5-difluorobenzoic acid) (H(2)ABDA

7 described HNO-donor sodium 1-(isopropylamino)diazene-1-ium-1,2-diolate (IPA/NO), and compare HNO prod

8 -formyl-4-((2E)-1-methylbut-2-en-1-yl)phenyl)diazene-1-oxide (13).

9 E)-2-chloro-1-(chloroimino)-2,2-dinitroethyl}diazene) (10), N1, N2-dichloro-1, 2-diazenedicarboximida

10 m ion center with loss of N(2) to generate a diazene 25 that subsequently decomposes into 21 with los

11 Arylazide and diazene activation by highly reduced uranium(IV) complex

12 ate in which FeMo-co binds the components of diazene (an N-N moiety, perhaps N2 and two [e(-)/H(+)] o

13 obacter vinelandii (Av) nitrogenase with two diazene analogues: diazirine, a photolabile diazene cont

14 y structures of 1-benzoyl-2-(perfluorophenyl)diazene and 1-(perfluorophenyl)-3-phenyl-1,4-dihydrobenz

15 o examine the energetics of the reactions of diazene and isodiazene with H(2) and the properties of t

16 N distance to the bond lengths of free N(2), diazene, and hydrazine.

17 he normal N2-reduction pathway, and that the diazene- and hydrazine-trapped turnover states represent

18 of signal intensity observed for hydrazine-, diazene-, and methyldiazene-trapped states.

19 Aromatic diazenes are often prepared by oxidation of the correspo

20 Diazenes are valuable compounds that have found broad ap

21 Aminonitrenes (1,1-diazenes) are central intermediates in nitrogen chemistr

22 talyst loadings to preclude oxidation to the diazene ArN=NAr.

23 oss-coupling reaction makes use of silylated diazenes as diazenyl anion equivalents, and chiral ferro

24 The UV absorption of this diazene at 382 nm indicates that the compound is the tra

25 ve cyanide, isocyanide, alkyne, N 2, alkene, diazene, azide, CO 2, carbodiimide, and Bronsted acid co

26 of the H2 releasing reaction indicates that diazene binding occurs prior to H2 elimination, and the

27 ve provides an overview of the underexplored diazene chemistry that has witnessed considerable progre

28 The rediscovered silicon-masked diazenes constitute a versatile platform possessing enha

29 -membered ring, and trans-dimethyldiazene, a diazene containing an unstrained trans-disubstituted N=N

30 diazene analogues: diazirine, a photolabile diazene containing the azo (-N=N-) group in a strained,

31 upport the intermediacy of a unique Ni-bound diazene-containing transition state with C-C bond format

32 ligands, cyanide, imidazole, and the phenyl(diazene)-derived radical inhibit superoxide generation.

33 NDOR establish that this state consists of a diazene-derived [-NHx] moiety bound to FeMo-cofactor.

34 The reaction proceeds through the novel aryl diazene-derived vinyl sulfoxonium ylide.

35 ereas treatment of RPA with oxidizing agent, diazene dicarboxylic acid bis[N,N-dimethylamide] (diamid

36 uadrigemine C, and (-)-psycholeine through a diazene-directed assembly of cyclotryptamine fragments i

37 monanthine headcap, we leverage the modular, diazene-directed assembly of stereodefined cyclotryptami

38 Our synthesis features the expedient diazene-directed assembly of two advanced fragments to s

39 is predicated on the convergent and modular diazene-directed assembly of two complex fragments to se

40 Through in situ generation of diazene during nitrogenase turnover, we show that diazen

41 union of complex amines in the form of mixed diazenes followed by photoexpulsion of dinitrogen in a s

42 lysed formal [2+2+1] reaction of alkynes and diazenes for the oxidative synthesis of penta- and trisu

43 anilines are particularly resistant towards diazene formation and participate in the amination of st

44 r ditopic or tetratopic aldehydes containing diazene functionality.

45 A transformation from cis- to trans-diazene has been found.

46 tate (denoted E4(2N2H)) with a moiety at the diazene (HN horizontal lineNH) reduction level bound to

47 or hydrazine formation, which proceeds via a diazene (HN=NH) intermediate and showcase light as a too

48 reby is activated to promptly generate bound diazene (HN=NH).

49 e intermediates at the level of reduction of diazene (HN=NH, also called diimide) and hydrazine (H2N-

50 -element HPPH complexes, adding to f-element diazenes (HNNH) that were first reported over thirty yea

51 in controlled retro-ene reaction of an allyl diazene, i.e., an allylic diazene rearrangement.

52 ted diazenes, pyrolysis of alkyl-substituted diazenes in the presence of molecular oxygen generates a

53 responds to the release of N(2) from the 1,1-diazene intermediate to form an open-shell singlet 1,4-b

54 hydrazine group into a highly reactive acyl diazene intermediate which reacts with an alpha-amino ac

55 dinitrogen from transiently formed monoalkyl diazene intermediates accessed by sequential Mitsunobu d

56 bonding as a potential strategy to stabilize diazene intermediates, we employ a series of [((x)Het)Tp

57 nt synthesis of highly complex bis- and tris-diazene intermediates.

58 varying the length of the tether within the diazenes investigated.

59 ne during nitrogenase turnover, we show that diazene is a substrate for the wild-type nitrogenase and

60 -N moiety, perhaps N2 and two [e(-)/H(+)] or diazene itself).

61 These observations suggest that diazene joins the normal N2-reduction pathway, and that

62 neN horizontal lineNR(2)] with a neutral 1,1-diazene ligand.

63 ctivation pathways to generate hydrazido and diazene ligands on Zn and Fe, respectively.

64 nsfer complex with ferric cytochrome a3; the diazene may serve to bridge the heme iron of this cytoch

65 Dibenzo-7-phosphanorbornadiene-substituted diazene MesN(2)PA (1, where Mes = mesityl, A = anthracen

66 nitrogenase under turnover conditions using diazene, methyldiazene (HN = N-CH(3)), or hydrazine as s

67 , which contains a conjugated core bearing a diazene moiety in the center of its electronically deloc

68 (Mes)PDI(Me)) (2-Cp*), only 1-Cp* can cleave diazene N horizontal lineN double bonds to form the same

69 termediates, including hydrazine (N(2)H(4)), diazene (N(2)H(2)), nitride (N(3-)) and imide (NH(2-)),

70 f lithium hydroxide forms lithium methanebis(diazene-N-oxide-N'-hydroxylate) and lithium pivalate.

71 of the previously observed sodium methanebis(diazene-N-oxide-N'-hydroxylate) and sodium acetate.

72 d sodium ethoxide to yield sodium methanebis(diazene-N-oxide-N'-hydroxylate) and sodium acetate.

73 ally hydrated forms of potassium methanetris(diazene-N-oxide-N'-hydroxylate) are characterized by sin

74 sults in the formation of lithium methanebis(diazene-N-oxide-N'-hydroxylate) exclusively.

75 s reaction of the silver salt of methanetris(diazene-N-oxide-N'-hydroxylate) with ammonium iodide, th

76 for the different conformers of methanetris(diazene-N-oxide-N'-hydroxylate)(3-) trianion, a new type

77 ion of six nitric oxides, sodium methanetris(diazene-N-oxide-N'-hydroxylate), forms as the main produ

78 potassium 3,3-dimethylbutan-2-one-1,1,1-tris(diazene-N-oxide-N'-hydroxylate), respectively.

79 Diazene (N2H2), a proposed 2e-/2H+ intermediate on the r

80 pha-70(Ala)/alpha-195(Gln) MoFe protein with diazene or hydrazine as substrate correspond to a common

81 A wide variety of previously unknown diazene precursors was synthesized and cyclized.

82 ppears that this band is actually due to the diazene produced as a result of the oxidation of the hyd

83 aryltrifluoromethyl enones or N-aryl-N-aroyl diazenes, providing useful synthetic building blocks in

84 Unlike the reaction of aryl-substituted diazenes, pyrolysis of alkyl-substituted diazenes in the

85 Diazene reacts rapidly with cytochrome c oxidase to redu

86 action of an allyl diazene, i.e., an allylic diazene rearrangement.

87 Diazene reduction, like N2 reduction, is inhibited by H2

88 ted by Ala during steady-state turnover with diazene resulted in conversion of the S = 3/2 resting st

89 nd N(3)Ad at ambient temperature to give the diazenes RN=NR (6a, R = Mes; 6b, R = Ad) in good yield.

90 the NI undergoes rapid oxidation to an acyl diazene species, which then facilitates N-acylation of a

91 oped a new strategy for iterative aryl-alkyl diazene synthesis using increasingly complex oligomeric

92 otryptamine monomers, respectively, used for diazene synthesis.

93 inates sulfinic acid, yielding a propargylic diazene that performs an alkyne walk to afford the allen

94 Starting from dienals and readily available diazenes, the strategy involving the hemiaminal formatio

95 mido via the disproportionation of an eta(2)-diazene-Ti(II) complex.

96 vity of the hydrogenation of artemisinate by diazene to form dihydroartemisinate (diastereoselective

97 A similar diazene to iron charge-transfer band is found following

98 oxidation-induced denitrogenation of cyclic diazenes to form 1,3-distonic radical cations that rearr

99 ponent reactions couple alkenes, alkynes and diazenes to form either alpha,beta-unsaturated imines or

100 There was no observed tautomerization of the diazenes to the corresponding arylhydrazones.

101 Ensuing high-yielding diazene-to-aldehyde tranformations and subsequent deriva

102 mically stable species such as diazomethane, diazenes, triazenes, and methyl azides, which further un

103 new methodology for synthesis of aryl-alkyl diazenes using electronically attenuated hydrazine-nucle

104 tion is bypassed by direct generation of 1,1-diazenes via synchronous cleavage of two N-N bonds.

105 The synthesis of these complex diazenes was made possible through a new methodology for

106 etone trityl hydrazone with tBuOCl to give a diazene which readily collapses to the alpha-chlorocarbi

107 ly eliminate methanesulfinic acid, affording diazenes which extrude nitrogen affording the desired de

108 sfer band is found following the reaction of diazene with ferric horseradish peroxidase and with hemi

109 Denitrogenation of the diazenes with an iridium photocatalyst then forges the C