ライフサイエンスコーパス: diazo

1 lopropanation reactions in the presence of 2-diazo-1,1,1-trifluoroethane (CF3CHN2) as the carbene don

2 The conversion of 1,3-diaryl-2-diazo-1,3-diketones to 1,2-daryl-1,2-diketones (benzils)

3 a thermally induced Wolff rearrangement of 2-diazo-1,3-diketones, and N-(5-pyrazolyl)imines as protot

4 eration of benzocyclobutene-1,2-dione from 2-diazo-1,3-indandione because of the difficulty of induci

5 carbonyls, and enoxy silanes react to give 2-diazo-1,4-dicarbonyl products.

6 es in the same molecule was examined using 3-diazo-1-(ethyl 2-diazomalonyl)indolin-2-one under rhodiu

7 phosphonate(9), enediyne(10,11), cyano(12), diazo(13), alkene(14) and alkyne(15-17) groups, continue

8 Esterification of GFP with 2-diazo-2-(p-methylphenyl)-N,N-dimethylacetamide was effic

9 lash photolysis of the caged Ca(2+) chelator diazo-2-acetoxymethyl ester, arrests mitosis.

10 escribed starting from decanal and diethyl 3-diazo-2-oxopropylphosphonate.

11 ) relaxed more slowly on flash photolysis of diazo-2.

12 2), 4; glycerol, GlO(2), 5) and dabco is 1,4-diazo[2.2.2.]bicyclooctane.

13 arboxylates, and are easily converted into 2-diazo-2H-pyrrole-4-carboxylates.

14 1-Diazo-3,3-dimethyl-5-phenylhex-5-en-2-one (2) reacts wit

15 sing methyl 3-(tert-butyldimethylsilyloxy)-2-diazo-3-butenoate (1) as a bifunctional reagent.

16 usly been found with a series of 2-alkynyl-2-diazo-3-oxobutanoates.

17 Irradiation of 2-diazo-3-oxochlorins (200 W, lambda > or = 345 nm, 10 deg

18 sis of metalated (Cu and Ni) and free base 2-diazo-3-oxochlorins within a frozen matrix (lambda = 457

19 Photolysis (lambda > 472 nm) of 2-diazo-3-pentyne (11) affords triplet 1,3-dimethylpropyny

20 Ethyl 2-diazo-4,4,4-trifluoro-3-oxobutanoate is a highly versati

21 ree-component process in which t-butyl (E)-2-diazo-5-arylpent-4-enoates are treated with Rh2(S-NTTL)4

22 ous acid yielded the primary explosive bis(4-diazo-5-nitro-3-oxopyrazolyl)methane (8), which showed s

23 The lead prodrug, isopropyl 6-diazo-5-oxo-2-(((phenyl(pivaloyloxy)methoxy)carbonyl)ami

24 loped prodrug of the glutaminase inhibitor 6-diazo-5-oxo-L-norleucine (DON) ameliorates social avoida

25 6-Diazo-5-oxo-l-norleucine (DON) is a glutamine antagonist

26 ntly, we show that glutaminase inhibitors, 6-Diazo-5-oxo-L-norleucine (DON) or CB-839, hypersensitize

27 Here we show that the glutamine analog 6-diazo-5-oxo-L-norleucine (DON) rescues mice from CM when

28 e investigated by chemical modulation with 6-diazo-5-oxo-L-norleucine (DON) to decrease or O-(2-aceta

29 t al. employ a broad glutamine antagonist, 6-diazo-5-oxo-l-norleucine (DON), to target a metabolic pr

30 The glutamine antagonist 6-diazo-5-oxo-l-norleucine (DON, 1) has shown robust antic

31 The glutamine antagonist 6-diazo-5-oxo-l-norleucine (DON, 14) attenuates glutamate

32 zyme by a small molecule glutamine analog (6-diazo-5-oxo-l-norleucine [DON]).

33 e more potent than the known GGT inhibitor 6-diazo-5-oxo-l-norleucine and are not toxic toward human

34 reover, experiments with the GGT inhibitor 6-diazo-5-oxo-l-norleucine and purified recombinant GGT pr

35 wever, targeting glutamine metabolism with 6-diazo-5-oxo-l-norleucine uniformly sensitized MM cell li

36 e anti-tumor effect of a glutamine analog (6-diazo-5-oxo-L-norleucine) as an adjuvant treatment to se

37 he effect of the glutamine antagonist DON (6-diazo-5-oxo-l-norleucine) on the outcome of NSV infectio

38 by the K9 DON peptide (with the Q isostere 6-diazo-5-oxo-norleucine) and iodoacetamide were further e

39 do-2-(adamantane-1-carboxamido)hexanamido)-6-diazo-5-oxohexanoate) showed stability in plasma, liver,

40 S-NTTL)4-catalyzed reaction of t-butyl (Z)-2-diazo-5-phenylpent-4-enoate gives the Buchner cyclizatio

41 at generates rhodium-carbynoids by selective diazo activation of designed carbyne sources.

42 Arrays of catalysed reactions of alpha-diazo amides, whose outcome was critically dependent on

43 on the nitrogen atom of the tethered alkenyl diazo amido indolo ester seemingly provides better orbit

44 he Rh(II)-catalyzed reactions of 2-alkynyl 2-diazo amido-substituted esters.

45 ch case, or (b) via addition of PhCCl to the diazo analogues of noradamantyl- and adamantyldiazirine.

46 The chemoselectivity of diazo and alkynyl groups enables dual labeling of cells

47 Diazo band integration reveals that photoisomerization f

48 Methods typically involve the formation of a diazo-based carbene precursor, but procedures using diaz

49 Diazo-based precursors of photolabile groups have been u

50 In this work we find that these diazo-based reagents in fact react very poorly with back

51 thod is efficient for the formation of alpha-diazo beta-carbocations (vinyldiazonium ions), vinyl car

52 ion of the pendant allyl group into an alpha-diazo beta-keto ester set the stage for Rh-mediated cycl

53 nation of a symmetrical indane-derived alpha-diazo beta-keto ester.

54 marked contrast to the cyclizations of alpha-diazo beta-ketoesters, which consistently deliver cyclop

55 However, attempts to use alpha-diazo-beta-ethylcaprolactone in intermolecular cycloprop

56 in agreement with the poor ability of alpha-diazo-beta-ethylcaprolactone to participate in intermole

57 pha,beta-unsaturated aldehydes affords alpha-diazo-beta-hydroxy-esters in high enantioselectivities.

58 ly at the 3-position of indole to give alpha-diazo-beta-indole carbonyls, and enoxy silanes react to

59 eto sulfoxides to form stable isolable alpha-diazo-beta-keto sulfoxides has been achieved for the fir

60 ium tetraacetate catalyzed reaction of alpha-diazo-beta-keto-carboxylates and -phosphonates with aren

61 cluded regiospecific cyclization of an alpha-diazo-beta-ketoester to build the cyclopentane ring, fol

62 iently accessed from the corresponding alpha-diazo-beta-ketoester, and a catalyst loading as low as 1

63 thers derived from methyl ketones with alpha-diazo-beta-ketoesters or alpha-diazoketones to afford 2-

64 ion-[2,3] sigmatropic rearrangement of alpha-diazo-beta-ketoesters possessing gamma-cyclic unsaturate

65 alpha-Diazo-beta-ketonitriles also undergo highly efficient in

66 These studies reveal that alpha-diazo-beta-ketonitriles exhibit unique reactivity in the

67 olecular cyclopropanation reactions of alpha-diazo-beta-ketonitriles is reported.

68 Alpha-diazo-beta-ketosulfones behave similarly and give 5-sulf

69 ramolecular C-H insertion reactions of alpha-diazo-beta-oxosulfones in the formation of fused thiopyr

70 With several medications (eg, sulfasalazine, diazo-bonded 5-aminosalicylates [ASA], mesalamines, and

71 rent oral 5-ASA therapies (sulfalsalazine vs diazo-bonded 5-ASAs vs mesalamine; low- (<2 g) vs standa

72 he singlet carbene p orbital in 5 (or of the diazo carbon in an excited state of 1) to the stronger a

73 alpha-diazo carbonyl compounds in which the diazo carbon was disubstituted, N-Boc imines react with

74 recombination through cation addition to the diazo carbon.

75 nactivated imines were not reactive to alpha-diazo carbonyl compounds in which the diazo carbon was d

76 alyzed carbenoid insertion reaction of alpha-diazo carbonyl compounds into Si-H and S-H bonds was dev

77 azirine-2-carbaldehydes, primary amines, and diazo carbonyl compounds under Rh(II) catalysis.

78 , formed in Rh2(OAc)4-catalyzed reactions of diazo carbonyl compounds with 2H-azirines, dramatically

79 ng versatile strategy of replacing hazardous diazo carbonyl compounds with benign and readily availab

80 dium(II)-catalyzed domino reactions of alpha-diazo carbonyl compounds, intramolecular [4 + 2]-cycload

81 es has been achieved successfully with alpha-diazo carbonyl compounds.

82 adily available alkynes instead of hazardous diazo carbonyl compounds.

83 venient to prepare by adding lithiated alpha-diazo carbonyls to alpha-oxy ketones.

84 Cyclic gamma-oxy-beta-hydroxy-alpha-diazo carbonyls undergo Lewis acid induced ring fragment

85 e fluorinated reagent with alpha-nitro-alpha-diazo carbonyls was established.

86 ld conditions by treating beta-hydroxy-alpha-diazo carbonyls with Sc(OTf)(3) .

87 n-acceptor-substituted aryl azides and alpha-diazo carboxylic esters are used as substrates for visib

88 first report on using aryl azides and alpha-diazo carboxylic esters as substrates for asymmetric cat

89 dical process with the aryl azides and alpha-diazo carboxylic esters serving as precursors for nitrog

90 oughs in the synthetically valuable field of diazo chemistry.

91 by varying the aldehyde, 1,3-dicarbonyl, and diazo component individually.

92 ohydrins and anion-stabilizing groups in the diazo-component are tolerated, affording novel functiona

93 at 2080 cm(-1) ascribed to the corresponding diazo compound 13D.

94 state leads to the formation of the isomeric diazo compound and singlet carbene.

95 ing the photoisomerization of diazirine into diazo compound and the denitrogenation into carbenes.

96 270 nm excitation, both singlet carbene and diazo compound are formed in a much more rapid process f

97 alyst, aldehyde, and amine, and instead, the diazo compound could be added directly.

98 g and irreversible and that insertion of the diazo compound favors electron-deficient substrates.

99 thane (BDE) produces an excited state of the diazo compound in acetonitrile, cyclohexane, and methano

100 stepwise process involving activation of the diazo compound leading to formation of a Co(III)-carbene

101 from [1,2,3]triazolo[1,5-a]pyridine 1T, the diazo compound lying ca. 5 kcal/mol above the triazole.

102 f distortion energies with substituents in a diazo compound or dipolarophile can enhance reactivity a

103 ever, the difficulty in forming the unstable diazo compound partner in a mild fashion has hitherto li

104 ced photochemically from their corresponding diazo compound precursors and studied spectroscopically

105 ived from rhodium(II) tetracarboxylate and a diazo compound) and a chiral spirophosphoric acid ((R)-S

106 ent proceeds via intermediate formation of a diazo compound, and can be catalyzed by acids via the pr

107 pyrrole-2-carboxylate into the corresponding diazo compound, followed by intramolecular azo coupling

108 nd carboxylic acid avoids the buildup of the diazo compound.

109 e to react for 20 min before addition of the diazo compound.

110 xcited state, generated by UV irradiation of diazo compound: isomerization to alpha-ketodiazirine pro

111 ed directed C-H bond functionalizations with diazo-compound substrates.

112 to as lambda(5)-phosphorus-containing alpha-diazo compounds (PCDCs), represent a vast class of extre

113 Catalysed X-H insertion reactions into diazo compounds (where X is any heteroatom) are a powerf

114 tionalization of aromatic molecules utilizes diazo compounds and a transition-metal catalyst to gener

115 can guide the design and application of both diazo compounds and azides in "orthogonal" contexts, esp

116 vatives are generally reliable precursors to diazo compounds and carbenes, although cyclization of th

117 The fact that diazo compounds and other carbene precursors are known m

118 tric coupling of flow-generated unstabilized diazo compounds and propargylated amine derivatives, usi

119 reaction between flow-generated unstabilized diazo compounds and terminal alkynes provides di- and tr

120 alyzed carbene transfer reactions, involving diazo compounds and their precursors, are powerful tools

121 d catalyzed reactions and transformations of diazo compounds are also discussed.

122 thane, alpha-diazo esters, and disubstituted diazo compounds are covered, commenting on the complex r

123 Diazo compounds are in widespread use in synthetic organ

124 coupling of aldehydes, 1,3-dicarbonyls, and diazo compounds as well as tosyl hydrazones.

125 Herein, we report that diazo compounds can be used to selectively alkylate the

126 New types of cyclic diazo compounds capable of Rh(II)-catalyzed spirocycliza

127 Diazo compounds derived from (p-methylphenyl)glycine wer

128 es are demonstrated, including examples with diazo compounds derived from biologically active compoun

129 In addition, vinyl diazo compounds gave enynes selectively as single geomet

130 both a nucleophile and an electrophile onto diazo compounds give a fast access into important buildi

131 ortho-alkylation of phenoxy substrates with diazo compounds has been achieved for the first time usi

132 pling of readily available boronic acids and diazo compounds has emerged recently as a powerful metal

133 Metal-stabilized carbenes derived from diazo compounds have become broadly useful reactive inte

134 ates the efficient conversion of azides into diazo compounds in phosphate buffer at neutral pH and ro

135 azides to unleash the power of these classic diazo compounds in the context of both inter- and intram

136 lkenes, alkynes, and allenes with diacceptor diazo compounds is reported.

137 catalyst for the reaction of aldehydes with diazo compounds leading to alpha-alkylated derivatives.

138 that such reagents would provide over either diazo compounds or their in situ precursors.

139 Notably, chemoselective arylation of diazo compounds over other electrophiles were demonstrat

140 This double functionalization of diazo compounds proceeds via selective S-alkylation foll

141 oyl benzhydroxamic acids with donor/acceptor diazo compounds provides isoindolones in high yield.

142 to a large variety of carboxylic acids using diazo compounds that are formed from the hydrazones of b

143 functionality to furnish alpha-cyclic-alpha-diazo compounds that are themselves subject to further t

144 In methanol, protonation of diazo compounds to give the corresponding 2-adamantyl ca

145 This review covers the addition of diazo compounds to ketones to afford homologated ketones

146 N-H insertion and cyclization sequence uses diazo compounds to stitch together linear 1,m-haloamines

147 oesters that possess beta-hydrogens, as such diazo compounds typically give rise to alkenes via beta-

148 ulative coupling of beta-ketothioamides with diazo compounds under mild reaction conditions for the f

149 tion conditions, while dicarbonyl-containing diazo compounds undergo carbonyl migration to afford 1-a

150 e highly enantioselective oxyalkynylation of diazo compounds using ethynylbenziodoxol-(on)e reagents

151 for the generation of an unstable family of diazo compounds using flow UV photolysis and their first

152 Rh(III)-catalyzed cyclization of oximes and diazo compounds via aryl and vinylic C-H activation.

153 light-promoted carbene transfer reactions of diazo compounds via free carbene intermediates have emer

154 The excited states of these diazo compounds were detected and found to decay with li

155 The diazo compounds were isolated in excellent yields (82-94

156 n Si-H insertion using carbenes derived from diazo compounds where selective formation of an enantioe

157 hrough rhodium catalyzed direct arylation of diazo compounds with arylboronic acids.

158 c acids, obtained by reacting flow-generated diazo compounds with boronic acids, and their applicatio

159 rans-aziridination of aldehydes, amines, and diazo compounds with BOROX catalysts is developed.

160 lving a copper-catalyzed oxy-alkynylation of diazo compounds with ethynylbenziodoxol(on)e (EBX) reage

161 The [3+2] cycloaddition of a variety of diazo compounds with o-(trimethylsilyl)aryl triflates in

162 rradiation (lambda > 497 nm) of the isomeric diazo compounds, 1-diazo-hexa-2,4-diyne (2) or 2-diazo-h

163 Using keto-diazo compounds, a ruthenium catalyzed O-H insertion wit

164 zomethine imines and ylides, nitrile oxides, diazo compounds, and other dipoles), and [4 + 2] cycload

165 from reaction of 2,3-diphenyl-2H-azirine and diazo compounds, do not produce indoles via 1,5-cyclizat

166 compounds demonstrate the reactivity of both diazo compounds, giving pyrrole-containing products of i

167 es a broad range of benzhydroxamic acids and diazo compounds, including substituted 2,2,2-trifluorodi

168 However, with other diazo compounds, primary thioamides also give enaminones

169 lticomponent cycloaddition reactions between diazo compounds, pyridines, and electrophilic alkenes to

170 Here, we show that diazo compounds, unlike azides, provide an opportunity t

171 eactions of symmetric diaziridines with enol diazo compounds, which react through N-N bond ring openi

172 from simple precursors without isolation of diazo compounds.

173 for its broad scope in both EBX reagents and diazo compounds.

174 clization methods based on the use of cyclic diazo compounds.

175 details on handling non-carbonyl-stabilized diazo compounds.

176 osition of hazardous, not easily accessible, diazo compounds.

177 isomerization of 3H-diazirines also afforded diazo compounds.

178 ontrolled with fumaronitrile by trapping the diazo compounds.

179 of trisubstituted aziridines from imines and diazo compounds.

180 o acids in partially aqueous conditions) and diazo compounds.

181 the imine was found to be independent of the diazo compounds.

182 s offered by these compounds over the parent diazo compounds.

183 tion and annulation of salicylaldehydes with diazo-compounds provided the desired chromones.

184 Structurally complex diazo-containing scaffolds are formed by conjugate addit

185 These reagents are synthesized by diazo coupling between phloroglucinol and a para-diazoph

186 , and Cu(II) , as well as SiO2 , to promote diazo decomposition and subsequent cyclization/rearrange

187 of reactions, triggered by Rh(II)-catalyzed diazo decomposition followed by a vinylogous N-H inserti

188 The cascade proceeds through diazo decomposition, carbene/alkyne metathesis, and C-H

189 structural dependence for relative rates of diazo decomposition.

190 ent nonmetal alternative to X-H insertion by diazo decomposition.

191 ManDiaz, which is a diazo derivative of N-acetylmannosamine, is found to end

192 The cascade reaction of alpha-diazo dihydroindolinone 21 proceeded in high yield with

193 ation/cycloaddition cascade of several alpha-diazo dihydroindolinones have been carried out as an app

194 ubstituent on one phenyl ring of a prochiral diazo enhances enantioselectivity up to 95:5 er with yie

195 The photochemistry of a p-biphenylyl diazo ester (BpCN2CO2CH3) and diazo ketone (BpCN2COCH3)

196 othesis that steric interactions between the diazo ester and adjacent silyloxy group can play an impo

197 Proper stereoelectronic alignment of the diazo ester and the departing hydroxyl group is necessar

198 of a urea catalyst and an alpha-nitro-alpha-diazo ester gives rise to a reactive species able to und

199 llowed the alternative use of an alpha-cyano diazo ester in the process, leading to alpha-cyano cyclo

200 Treating an alpha-diazo ester indole addition product with Rh(2) (OAc)(4)

201 used to study the photochemistry of a vinyl diazo ester PhCH=CHCN2CO2CH3 (1) in solution.

202 The diazo ester produces singlet carbene with greater quantu

203 ted phenoxypyrimidine and 3 mol equiv of the diazo ester.

204 nterceptive [4 + 1] annulation strategy with diazo esters (DEs).

205 stituted, N-Boc imines react with both alpha-diazo esters and alpha-diazo-N-acyloxazolidinones to giv

206 of cyclic gamma-silyloxy-beta-hydroxy-alpha-diazo esters provided tethered aldehyde ynoate intermedi

207 -unsaturated esters, beta-indole-substituted diazo esters, and dienes are obtained with good to high

208 omethanes, trimethylsilyldiazomethane, alpha-diazo esters, and disubstituted diazo compounds are cove

209 al-catalyzed reactions of alkynes with alpha-diazo esters, can be utilized directly in carbozincation

210 ceptor carbenoids derived from unsubstituted diazo esters.

211 I)-catalyzed reaction of cyclopropanols with diazo esters.

212 lkyl-substituted allylic sulfides) and alpha-diazo esters.

213 ased carbene precursor, but procedures using diazo-free metal carbenes have been developed with signi

214 o a complex cyclopentadiene to introduce the diazo function.

215 y gold in which the terminal nitrogen of the diazo functional group adds to the central carbon of the

216 Importantly, the diazo functional group is retained within the molecule f

217 cationic gold complexes are initiated at the diazo functional group to form a gold carbene whose subs

218 es subject to further transformations of the diazo functional group; (2) [3+n]-cycloadditions (n = 1-

219 of enoldiazo compounds with retention of the diazo functionality to furnish alpha-cyclic-alpha-diazo

220 ate into several aldehydes, oxidation of the diazo functionality, and diastereoselective alkyl transf

221 We introduce a stabilized diazo group as a reporter for chemical biology.

222 There its diazo group can undergo a 1,3-dipolar cycloaddition with

223 e to the greater nucleophilic character of a diazo group compared to that of an azido group, which ca

224 The diazo group has attributes that complement those of the

225 de insights into the chemoselectivity of the diazo group in 1,3-dipolar cycloadditions.

226 The metallo carbenoid derived from the D/A diazo group is preferentially formed and undergoes selec

227 Additional experiments with diazo group transfer to lithium hydrazides show that int

228 A diazo group was introduced as a protecting group for an

229 of a nucleophile and an electrophile to the diazo group, has been realized in the intramolecular ami

230 A novel mode of reactivity for the diazo group, the 1,3-addition of a nucleophile and an el

231 Thus, the diazo group, which is approximately half the size of an

232 olely with the pi-donor rather than with the diazo group.

233 l angucycline ring system substituted with a diazo group.

234 Notably, these advantages of diazo groups are amplified in water.

235 > 497 nm) of the isomeric diazo compounds, 1-diazo-hexa-2,4-diyne (2) or 2-diazo-hexa-3,5-diyne (3),

236 o compounds, 1-diazo-hexa-2,4-diyne (2) or 2-diazo-hexa-3,5-diyne (3), generates triplet carbene 1.

237 Rh(II)-catalyzed decomposition of alpha-diazo homophthalimides in the presence of cyclic ethers

238 of the stemofoline alkaloids from an acyclic diazo imine intermediate.

239 mical instability cyclizing to form a unique diazo-imine.

240 ation/cycloaddition cascade of several alpha-diazo indolo amido esters have been carried out as an ap

241 The Cu(II)-catalyzed reaction of an alpha-diazo indolo diester that contains a tethered oxa-penten

242 lar [3+2]-cycloaddition reaction of an alpha-diazo indoloamide which delivers the pentacyclic skeleto

243 on experiments demonstrate the presence of a diazo intermediate and methyl acetate in all photochemic

244 f the substrate is due to the formation of a diazo intermediate which encounters a nucleophilic attac

245 a p-biphenylyl diazo ester (BpCN2CO2CH3) and diazo ketone (BpCN2COCH3) were studied by ultrafast time

246 In the case of diazo ketone compounds, this shift occurred spontaneousl

247 Both diazo ketone excited states decompose in less than 300 f

248 The key ring-forming reaction, in which a diazo ketone is converted into a bridged bicyclic ether,

249 hane in the outer chamber, and the resulting diazo ketone is finally converted to the halo ketone wit

250 The alpha-diazo ketone is produced from the mixed anhydride and di

251 ction of a metal carbenoid, generated from a diazo ketone, with an ether to produce an ylide-like int

252 al or photochemical Wolff rearrangement of a diazo ketone.

253 arrangement (WR) in the excited state of the diazo ketone.

254 Some long chain alpha-aryl alpha-diazo ketones under Rh catalysis cyclize efficiently to

255 The photochemistry of two isomeric aryl diazo ketones was investigated by fs time-resolved UV-vi

256 n based on the reaction of cyclobutenones or diazo ketones with N-propargyl-substituted ynamides proc

257 intermolecular cascade reaction of aromatic diazo ketones with olefins has been developed.

258 al carbene chemistry without using hazardous diazo ketones.

259 The diazo-linker of UiO-abdc possesses local site disorder,

260 y host-guest interaction between beta-CD and diazo-linker works as a gatekeeper to control the releas

261 r/acceptor (D/A) and acceptor/acceptor (A/A) diazo moieties in the same molecule was examined using 3

262 ty at the alpha-position with respect to the diazo moiety, here referred to as lambda(5)-phosphorus-c

263 Indeed, thanks to the high reactivity of the diazo moiety, PCDCs can be induced to undergo a wide var

264 react with both alpha-diazo esters and alpha-diazo-N-acyloxazolidinones to give trisubstituted azirid

265 Photolysis of alpha-diazo-N-methoxy-N-methyl (Weinreb) beta-ketoamides deriv

266 ons of MEDAM imines and three representative diazo nucleophiles has been studied using ONIOM(B3LYP/6-

267 ls that photoisomerization from diazirine to diazo occurs within a few picoseconds of the laser pulse

268 of alpha-oximino ketenes derived from alpha-diazo oxime ethers provides 2H-azirines bearing quaterna

269 For metalated diazo-oxochlorins, these products compete with intramole

270 ((1)2) is produced from the excited state of diazo precursor (1*).

271 roach of substrates to carbenes from acyclic diazo precursors may be relatively slow due to a steric

272 ohols with N-alkyl-N-hydroxyl amides to give diazo precursors, which upon intramolecular cyclopropana

273 ere evaluated with symmetrical and prochiral diazo reactants to produce a total of 25 novel silanes.

274 opropanation with the acceptor/acceptor-type diazo reagent alpha-cyanodiazoacetates.

275 alyzed arylation of a Meldrum's acid-derived diazo reagent with electron-rich arenes is described.

276 the products were derivatized using a novel diazo reagent.

277 ment reaction involving allylic sulfides and diazo reagents (Doyle-Kirmse reaction) is reported.

278 ocol that can effectively utilize donor-type diazo reagents for asymmetric olefin cyclopropanation.

279 Donor-substituted diazo reagents, generated in situ from sulfonyl hydrazon

280 none were synthesized from the corresponding diazo substrates in varying yields.

281 other similar acceptor-acceptor-substituted diazo substrates instead produce mixtures of C-H inserti

282 mical alternative to the strategies based on diazo substrates.

283 Diazo sulfonylamidines readily undergo enantioselective

284 lladium-catalyzed cyclization (39-->37), and diazo transfer (37-->53).

285 Under diazo transfer conditions in the presence of a base in a

286 tic studies show the reaction proceeds via a diazo transfer mechanism.

287 the juglone derivative 61, cyclization, and diazo transfer provided the advanced diazofluorene 63, w

288 Diazo transfer reactions on Behera's amine and its next-

289 ation, Bamford-Stevens-type elimination, and diazo transfer reactions.

290 methylene compounds as well as deformylative diazo transfer reagent.

291 vides a considerable advantage over existing diazo transfer reagents in terms of impact stability, co

292 Diazo transfer to beta-keto sulfoxides to form stable is

293 en sulfate salt as the reagent of choice for diazo transfer.

294 were successfully explored as substrates for diazo transfer.

295 and salts thereof are valuable reagents for diazo-transfer reactions, most particularly conversion o

296 orted recently as a new "intrinsically safe" diazo-transfer reagent.

297 ic scaffold of the natural product, and mild diazo-transfer to a complex cyclopentadiene to introduce

298 he resin-bound peptide to selective on-resin diazo transformation of a Lys into the Nle(epsilon-N3) o

299 Placing the carbene producing 21-diazo/triazolo moiety of the photoprobe in the vicinity

300 n the basis of hypervalent alpha-aryliodonio diazo triflate salts 1A, 2A, and 3A, the corresponding h