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2 The recent scalable synthesis of cubane-1,4-dicarboxylic acid (1,4-H(2)cdc) allows the first opportu
3 ptor agonist (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S, 3R-ACPD), the group I mGlu recept
4 onist, (1S,3R)-1-aminocyclopentane-trans-1,3-dicarboxylic acid (1S, 3R-t-ACPD), similarly resulted in
5 ) exposure to 1S, 3R-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) (100 microM) is suppressi
6 of 50 microM (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) depolarized all neurones
7 tive mGluR agonist 1-aminocyclopentane-1S,3R-dicarboxylic acid (1S,3R-ACPD) results in contralateral
8 e occluded by 1S,3R-1-aminocyclopentane-1, 3-dicarboxylic acid (1S,3R-ACPD), suggesting they are not
10 ,9b-tetrahydro-3H-cyclopenta[c]quinoline-4,8-dicarboxylic acid (5661118) and the naphthofurandione 3-
11 ectrum mGluR agonist 1-aminocyclopentane-1,3-dicarboxylic acid (ACPD) decreased the frequency of GABA
12 agonist, (+/-)-1-aminocyclopentane-trans-1,3-dicarboxylic acid (ACPD) produced a robust, long-lasting
14 ct on either (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (ACPD, an mGLU receptor agonist) or 5-
15 activated by (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (ACPD; 300 microM) and (R,S)-3,5-dihyd
16 The group I antagonist (RS)-1-aminoindan-1,5-dicarboxylic acid (AIDA) and the group II antagonists LY
17 oxyphenylglycine (MCPG) and 1-aminoindan-1,5-dicarboxylic acid (AIDA) but not by the presynaptic meta
18 receptor agonist and (RS)-1-aminoindan-1, 5-dicarboxylic acid (AIDA), a selective mGluR1alpha antago
19 this challenge with 1,4-bicyclo[2.2.2]octane dicarboxylic acid (BODCA)-MOF, a metal-organic framework
21 he uptake of the 1:1 chelate of pyridine-2,6-dicarboxylic acid (DPA(2,6)) and Ca(2+) into developing
22 uth and dithieno[3,2-b:2',3'-d]thiophene-2,6-dicarboxylic acid (DTTDC), an electron-rich linker with
23 tion to convert 2-furoic acid into furan-2,5-dicarboxylic acid (FDCA)--a highly desirable bio-based f
24 xylic acid (H(2)Me(2)BPDC) and biphenyl-4,4'-dicarboxylic acid (H(2)BPDC), which are commonly used bu
25 of AlCl(3).6H(2)O with 2,2'-bipyridine-5,5'-dicarboxylic acid (H(2)bpydc) affords Al(OH)(bpydc) (1,
26 organic linkers, 2,2'-dimethylbiphenyl-4,4'-dicarboxylic acid (H(2)Me(2)BPDC) and biphenyl-4,4'-dica
27 he phenol groups in 2,5-dihydroxybenzene-1,4-dicarboxylic acid (H4DOBDC) have been replaced by thioph
28 on of MnCl2 with 2,5-disulfhydrylbenzene-1,4-dicarboxylic acid (H4DSBDC), in which the phenol groups
29 Pimelic acid, a seven carbon alpha,omega-dicarboxylic acid (heptanedioic acid), is known to provi
30 of WT astrocytes to l-trans-pyrrolidine-2,4-dicarboxylic acid (l-trans-PDC) or by partial suppressio
31 agonist, (-)-2-oxa-4-aminobicylco hexane-4,6-dicarboxylic acid (LY379268), antagonizes reinstatement
32 st (-)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylic acid (LY379268; 0.3-1 mg/kg i.p.) increased
33 ,3S)-(1-biphenylyl-4-carbonyl)piperazine-2,3-dicarboxylic acid (PBPD, 16b) displays an unusual select
34 amate receptor antagonist cis-2,3-piperidine dicarboxylic acid (PDA) increased paired-pulse depressio
35 lock the On-pathway; and cis-2, 3 piperidine dicarboxylic acid (PDA) to block the Off-pathway and the
36 a combination of APB and cis-2,3 piperidine dicarboxylic acid (PDA) was used to isolate the contribu
38 atergic transmission with cis-2,3 piperidine dicarboxylic acid (PDA, 3.3-3.8 mM, n = 3) or laser-indu
40 ate reuptake blocker l-trans-pyrrolidine-2,4-dicarboxylic acid (PDC) (10 nmol per side), the D(1)-lik
41 mate uptake inhibitor, trans-pyrrolidine-2,4-dicarboxylic acid (PDC) for 3 weeks, or a higher level (
42 te reuptake blocker, l-trans-pyrrolidine-2,4-dicarboxylic acid (PDC), were made in the freely moving
44 nd 1-(phenanthrene-2-carbonyl)piperazine-2,3-dicarboxylic acid (PPDA), have discrete binding modes an
45 enzyl-4-oxo-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid (SD-1008) as a micromolar inhibitor of
48 In addition, 1-aminocyclopentane-trans-1,3-dicarboxylic acid (trans-ACPD), a group I mGluR agonist,
50 otection of the hydroxy groups to give novel dicarboxylic acid 11 or dialdehyde 16 in practical yield
51 iazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2, 6-dicarboxylic acid 14a (LY2812223) was further characteri
55 roexcitants 3-(carboxymethyl)pyrrolidine-2,4-dicarboxylic acid 43, alpha-kainic acid 12, alpha-isokai
56 mGluR agonist, 1-aminocyclopentane-trans-1,3-dicarboxylic acid [(1S, 3R)-ACPD, 0.5 nmol/side] and amp
57 luR agonist (1S,3R)-1-amino-1,3-cyclopentane-dicarboxylic acid [(1S,3R)-ACPD], group I/II antagonist
58 honopionic acid (L-AP3), (RS)-aminoindan-1,5-dicarboxylic acid and (RS)-alpha-methylserine-o-phosphat
59 modate the bulky aromatic ring of a pyridine dicarboxylic acid and a negative charge at the C3 but no
60 sporter inhibitors, L-trans-pyrrolidine-2, 4-dicarboxylic acid and dihydrokainic acid, were plotted a
62 h a severalfold reduction in very long chain dicarboxylic acid and omega-hydroxy fatty acids typical
63 eotide (CHPR) from 4-hydroxy-1H-pyrazole-3,5-dicarboxylic acid and phosphoribosyl pyrophosphate (PRPP
65 n of the aldimine of 4-aminocyclopentane-1,3-dicarboxylic acid and PMP (20), which disrupts an electr
66 lyze the coupling of 4-amino-1H-pyrazole-3,5-dicarboxylic acid and PRPP to form carboxyaminopyrazole
70 mides) derived from 3,5-diamino-pyrazine-2,5-dicarboxylic acid bearing neutral and anionic groups wer
71 ining [6,6']bi[thieno[3,4-b]thiophenyl]-2,2'-dicarboxylic acid bis-(2-butyloctyl) ester (BTT) and 4,8
72 eatment of RPA with oxidizing agent, diazene dicarboxylic acid bis[N,N-dimethylamide] (diamide), sign
73 birch pulp derivate, nanofibrillated anionic dicarboxylic acid cellulose (DCC), having widths of fibr
74 vary considerably in the presence of various dicarboxylic acid chelators, suggesting that the similar
75 zo)-24-crown-8 by reaction with pyridine-2,6-dicarboxylic acid chloride in 42 and 48% yields, respect
76 title compounds was carried out by reacting dicarboxylic acid chlorides with oximes in the presence
78 O(-)](2), is a colorless insulator where the dicarboxylic acid cocrystallizes with two of its monoani
79 etween a suite of various monocarboxylic and dicarboxylic acid concentrations are consistent with doc
81 ycloaddition reaction of unsaturated vicinal dicarboxylic acid derivatives and in situ generated azom
82 prepare "unsymmetrical" 4-aryl-isoxazol-3,5-dicarboxylic acid derivatives from nitroacetic esters an
88 In 2002, the plasticizer 1,2-cyclohexane dicarboxylic acid diisononyl ester (DINCH) was introduce
89 ubstituted derivatives of cis-piperazine-2,3-dicarboxylic acid display improved relative affinity for
91 ety in 7-oxabicyclo[2.2.1]hept-2,5-diene-2,3-dicarboxylic acid esters serves as both a tunable electr
92 almitate by cultured fibroblasts and urinary dicarboxylic acid excretion; and (5) hepatic lipid perox
93 nthesized by polymerization of Imidazole-4,5-dicarboxylic acid functionalized Allyl chloride, and sig
94 e dicarboxylic acid linker with 2,3-pyrazine-dicarboxylic acid furnished a highly selective nanomolar
95 uded ellagitannins (1-11), gallic acid (12), dicarboxylic acid glucosides (13-15), hydrojuglone gluco
97 ached to the N(1) position of piperazine-2,3-dicarboxylic acid have been synthesized to probe the str
99 lmethyl]-4-hydroxy-bicy clo[3.1.0]hexane-2,6-dicarboxylic acid hydrochloride (LY3020371.HCl, 19f), a
103 ogenous amino acids, L-trans-pyrrolidine-2,4-dicarboxylic acid in the presence of 8.3 mM glucose pote
104 romethyl carboxylic acid indolylfulgimide 4, dicarboxylic acid indolylfulgimide 5, and carboxylic aci
105 involves the transformation of imidazole-4,5-dicarboxylic acid into dissymmetrically disubstituted I4
107 al chlorination of bicyclo[1.1.1]pentane-1,3-dicarboxylic acid is highly selective, and up to four ch
110 Replacement of the Pro(6) residue and the dicarboxylic acid linker with 2,3-pyrazine-dicarboxylic
115 nal 4-chlorophenylhydrazones showed that the dicarboxylic acid moiety of CPHM is essential for activi
116 titumor activity of an 18 carbon alpha,omega-dicarboxylic acid monoconjugated via an ester linkage to
117 mGluR receptor antagonists 1-aminoindan-1,5-dicarboxylic acid or L-(+)-2-amino-3-phosphonopropionic
119 , synthesis of the seven carbon alpha, omega-dicarboxylic acid pimelate moiety and assembly of the fu
121 otide receptor family containing CysLTRs and dicarboxylic acid receptors with trans-activator reporte
122 S,2R,5R,6R)-2-amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid scaffold to generate mGlu2/3 antagonis
124 residue and might provide recognition via a dicarboxylic acid structure, we screened cDNAs within th
125 high density on a putatively nonfermentative dicarboxylic acid substrate depends on a malolactate exc
126 red necessary for energy production from the dicarboxylic acid substrates malate, succinate, and fuma
127 rary, based on a symmetrical isoindoline-5,6-dicarboxylic acid template and including the optimized b
128 g (SH) chemicals such as diglycidyl ether or dicarboxylic acid terminated polydimethylsiloxane (PDMS-
130 The AAA+ domain of Sinorhizobium meliloti C4-dicarboxylic acid transport protein D (DctD) is sufficie
131 the expression of genes encoding a predicted dicarboxylic acid transport system, a putative formate t
132 rt that a SLC26/SulP protein acts as a C(4) -dicarboxylic acid transporter and an unexpected new func
136 ic polyesters varying in the length of their dicarboxylic acid unit and of poly(butylene adipate-co-t
140 id (PMPA) and 4,4'-phosphinicobis(butane-1,3-dicarboxylic acid) (PBDA) were built by a computational
142 ethyl)phenanthrene-2-carbonyl)piperazine-2,3-dicarboxylic acid) inhibits GluN2C/2D with 40-fold selec
143 Cl2 and H4DSBDC (2,5-disulfhydrylbenzene-1,4-dicarboxylic acid) leads to the formation of Fe2(DSBDC),
144 cular Ru-bda (H(2)bda = 2,2'-bipyridine-6,6'-dicarboxylic acid) water oxidation catalysts, we carried
145 Rh(bpydc)Cl(2) (bpydc = 2,2'-bipyridine-5,5'-dicarboxylic acid) were coimmobilized in the Zr(IV) base
146 vinyl)phenanthrene-2-carbonyl)piperazine-2,3-dicarboxylic acid) which shows over 50-fold GluN2C/2D-se
147 Trans-ACPD (1-aminocyclopentane-trans-1S,3R-dicarboxylic acid), a broad-spectrum metabotropic glutam
148 ,4''-dihydroxy-[1,1':4',1''-terphenyl]-3,3''-dicarboxylic acid), and three modified terphenyl derivat
149 I) bis(2,2'-bipyridine) (2,2'-bipyridyl-5,5'-dicarboxylic acid), RuDCBPY, into a UiO-67 metal-organic
150 dobpdc = 4,4'-dihydroxy-[1,1'-biphenyl]-3,3'-dicarboxylic acid), the terphenyl derivative Fe2(dotpdc)
151 uR(1) antagonist, AIDA((RS)-1-Aminoindan-1,5-dicarboxylic acid), were examined on nociceptive neurons
152 s (or to a hexameric complex in a "U-shaped" dicarboxylic acid), which is fully expected since the tw
153 atible and biodegradable polymer, poly(triol dicarboxylic acid)-co-poly(ethylene glycol) (TDP), is ac
155 Y379268 ((-)-2-oxa-4-aminobicylco hexane-4,6-dicarboxylic acid)] on contextual cue-induced reinstatem
157 te-uptake inhibitor (M-trans-pyrrolidine-2,4-dicarboxylic acid, 1 mum), blocked by a Group II mGluR a
159 nd it was blocked by L-trans-pyrrolidine-2,4-dicarboxylic acid, a blocker of neuronal and glial gluta
160 also incapable of accommodating pyridine-2,6-dicarboxylic acid, a competitive inhibitor of the native
162 of the phthalate alternative 1,2-cyclohexane dicarboxylic acid, diisononyl ester (DINCH), were only a
163 ted by acyl transfer from the CoA ester of a dicarboxylic acid, followed by decarboxylation in situ b
164 obile metabolite azelaic acid, a nine-carbon dicarboxylic acid, in the vascular sap of Arabidopsis th
166 c mGluR agonist 1S, 3R-aminocyclopentane-1,3-dicarboxylic acid, it fails to block PI turnover and cha
167 Pyrrole-2,3, 5-tricarboxylic and pyrrole-2,3-dicarboxylic acid, specific degradation products of cate
168 transport inhibitor l-trans-pyrrolidine-2,4-dicarboxylic acid, the neuroprotective effects of halope
169 etrapropoxy-5,17-dibromo-calix[4]arene-11,23-dicarboxylic acid, two 1:1 dimetal:calixarene compounds
170 MOF) derivative in which 2,2'-bipyridyl-5,5'-dicarboxylic acid, UiO-67-DCBPY, is used in place of 4,4
171 ruxillic acid or 2,4-diphenylcyclobutane-1,3-dicarboxylic acid, was readily synthesized from commerci
173 of multimeric RGD compounds constructed on a dicarboxylic acid-containing near-infrared (NIR) fluores
174 o antagonize (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid-induced inhibition of forskolin stimul
175 o antagonize (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid-induced inhibition of forskolin-stimul
183 crystal structure of the KDM4B.pyridine 2,4-dicarboxylic acid.H3K9me3 ternary complex, revealing the
184 pyrolysis of dipicolinic acid (pyridine-2,6-dicarboxylic acid; DPA), a substance found in spores but
185 GluR1 antagonist AIDA [(RS)-1-aminoindan-1,5-dicarboxylic acid] but not by group II mGluR antagonist
189 c, acrylic and delta-amino levulinic acids), dicarboxylic acids (2,5-furandicarboxylic, maleic, succi
190 everal additional markers of ESRD, including dicarboxylic acids (adipate, malonate, methylmalonate, a
191 P450 CYP4A omega-oxidation enzymes to toxic dicarboxylic acids (DCAs) that serve as substrates for p
192 , but does not activate >C3 organic acids or dicarboxylic acids (e.g. butyrate, malonate and succinat
193 nesoic acid, and finally to farnesol-derived dicarboxylic acids (FDDCAs) which would then be excreted
194 -marine mixed air had more abundant hydroxyl dicarboxylic acids (OHDCA), with anthropogenic unsaturat
196 etabolites identified as the chain-shortened dicarboxylic acids 18-COOH-18:4, 18-COOH-18:3, and 16-CO
197 mplementary: maximum binding is observed for dicarboxylic acids and dicarboxylates with four-carbon c
198 ate that YchM can also transport other C(4) -dicarboxylic acids and that its substrate specificity di
199 mpact of water infusion was the greatest for dicarboxylic acids and the least for (hetero-) aromatic
203 As further shown, the previously unreported dicarboxylic acids are easily turned into corresponding
204 saturated and unsaturated fatty acids and of dicarboxylic acids are either unavailable or have been e
207 es nitrogen in symbiosis with soybean, where dicarboxylic acids are its principal carbon substrate.
209 n this work, we sought definitive proof that dicarboxylic acids are produced in diesel engines and th
211 difference in the Ki values for a series of dicarboxylic acids as inhibitors of 5-CHO-H4PteGlu5, sug
212 ilable, Sinorhizobium meliloti utilizes C(4)-dicarboxylic acids as preferred carbon sources for growt
213 ctions of ZrCl(4) and single or mixed linear dicarboxylic acids bearing methyl or azide groups lead t
214 -Arg-Nva-Arg-Tyr-NH(2) using various diamino-dicarboxylic acids containing either di-, tri-, or tetra
215 terminus with monocarboxylic or alpha,omega-dicarboxylic acids containing six to sixteen carbon atom
216 Here we report a novel pathway to odd-carbon dicarboxylic acids directly from glucose in Escherichia
218 ed citronellol, acetaldehyde, ethyl acetate, dicarboxylic acids esters, benzenoids, furans and acetal
220 ectroscopy technique to measure 11 mono- and dicarboxylic acids from plain and KOH impregnated quartz
223 ar condensation of a series of monoesters of dicarboxylic acids have been shown to be highly dependen
224 nalogues than does the alpha-Kg site or that dicarboxylic acids have more than one binding mode on th
228 behavior of a well-defined model system of 9 dicarboxylic acids is investigated directly with complem
229 ith betabeta'-methyl-substituted alpha-omega-dicarboxylic acids of C14-C18 in wild-type animals also
230 e cocrystals contain aliphatic even-numbered dicarboxylic acids of increasing chain length, and as a
231 re covalently cross-linked by acylation with dicarboxylic acids of increasing length, namely the fuma
233 of CCN activation for particles composed of dicarboxylic acids or secondary organic aerosol and ammo
236 against both the shorter and the longer keto dicarboxylic acids that could potentially serve as alter
237 ochrome P450 CYP4A omega-oxidation system to dicarboxylic acids that serve as substrates for peroxiso
238 mmonium sulfate enhances the partitioning of dicarboxylic acids to aqueous particles more than curren
239 e inversely associated with mAb+ risk, while dicarboxylic acids were associated with an increased ris
240 stenol, several secondary fatty alcohols and dicarboxylic acids were identified for the first time in
241 diamino-1,2,3,5,6,7-hexahydro-s-indacene-2,6-dicarboxylic acids were synthesized and the structures a
242 zed reaction of readily available tripyrrane dicarboxylic acids with 1,3-azulenedicarbaldehyde, follo
243 n with hex-3-enedioic acid gives unsaturated dicarboxylic acids with adjustable mean chain lengths as
245 ) (a standard criterion for non-H-bonding in dicarboxylic acids) for both 1 and 2 in water and also f
248 mpounds such as phenols and acids, aliphatic dicarboxylic acids, and reduced nitrogen species such as
249 ored carbon substrates, including starch and dicarboxylic acids, as well as sucrose, major amino acid
250 0 parts per million) that includes mono- and dicarboxylic acids, dicarboximides, pyridine carboxylic
251 selective for VFAs, it shows no response to dicarboxylic acids, hydroxycarboxylic acids, or aromatic
253 ammonium sulfate (AS)/nitrate (AN) and C3-C5 dicarboxylic acids, namely, malonic, malic, succinic, an
254 effect of ammonia on the partitioning of two dicarboxylic acids, oxalic (C2) and adipic (C6) is deter
255 le and could not utilize nitrate, urea, C(4)-dicarboxylic acids, several amino acids, or concentratio
256 hydroxidoplatinum(IV) precursors and various dicarboxylic acids, such as oxalic, malonic, 3-methylmal
257 ble organic carbon was identified as benzene dicarboxylic acids, tricarboxylic acids, and tetracarbox
258 ere, the evaporation behavior of mixtures of dicarboxylic acids, which are common atmospheric aerosol
259 ly results in formation of the corresponding dicarboxylic acids, which are further metabolized and en
260 ly results in formation of the corresponding dicarboxylic acids, which are further metabolized in the
261 predominantly allows sugars to be made from dicarboxylic acids, which are products of lipid breakdow
262 uated using C13-C18 monocarboxylic and C6-C8 dicarboxylic acids, which have vapor pressures at 25 deg
263 omega-oxidized to generate alpha-chlorinated dicarboxylic acids, which include alpha-chloroadipic aci
273 droxy forms, comparable in severity with the dicarboxylic aciduria of children with primary defects o
274 ic evaluation revealed fasting hypoglycemia, dicarboxylic aciduria, and reduced activity of the elect
275 ing state developed a distinctive and marked dicarboxylic aciduria, including saturated, unsaturated,
278 ines in PL2 and Ct and the presence of three dicarboxylic amino acids in PL2 appears to be necessary
280 which derive the short-chain carboxylic and dicarboxylic and the medium-chain fatty acids that have
282 ytotoxic effects of aluminum (Al) by exuding dicarboxylic and tricarboxylic acids that chelate and im
286 e desymmetrization of endo-norborn-5-ene-2,3-dicarboxylic anhydrides by methyl (S)-prolinate followed
287 dium-chain fatty acids, and higher levels of dicarboxylic fatty acids and 2-hydroxybutyrate (a known
292 uding short-chain, medium-chain, long-chain, dicarboxylic, hydroxylated, and unsaturated acyl moietie
294 69 play key roles in specific recognition of dicarboxylic keto (prephenate) and amino (aspartate) aci
296 including omega-phenylalkanoic, alpha,omega-dicarboxylic, omega-hydroxy, omega-1-oxo, omega-1-methyl
297 opanoic, p-toluic, and cis-pinonic acid) and dicarboxylic (oxalic, succinic, malic, adipic, and azela
299 h reacts only with the dianionic form of the dicarboxylic substrate, the R11A mutant reacts with both
300 ; it selectively disfavors interactions with dicarboxylic substrates and inhibitors compared to aroma