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1 tions (glucose +/- palmitate +/- insulin +/- dichloroacetate).
2 s partially restored by PDK4 inhibition with dichloroacetate.
3 rol tumors and following drug treatment with dichloroacetate.
4 vate dehydrogenase kinase-specific inhibitor dichloroacetate.
5 idosis in malaria can be treated safely with dichloroacetate.
6 c clamp, with or without coadministration of dichloroacetate.
7 l/L palmitate, and 50 microU/mL insulin plus dichloroacetate 5 mmol/L or glucose and insulin increase
8 minish this traffic in rats by administering dichloroacetate (50 mgkg) intravenously to stimulate ast
9 duct of fatty acid beta-oxidation [FAO]), or dichloroacetate, a compound that promotes pyruvate oxida
10       Treatment of cardiac Mtch mutants with dichloroacetate, a pyruvate dehydrogenase kinase inhibit
11                                              Dichloroacetate also decreased glucose and pyruvate prod
12 ractile reserve, a group of animals were fed dichloroacetate, an activator of pyruvate oxidation.
13      Treatment of B6.Sle1Sle2.Sle3 mice with dichloroacetate, an inhibitor of lactate production, fai
14                                  Exposure to dichloroacetate, an inhibitor of PDKs, increased mitocho
15 , either through PDH kinase (PDK) inhibitors dichloroacetate and AZD7545 or short hairpin RNA-specifi
16 nuated in the presence of iron deficiency by dichloroacetate and imatinib, 2 putative treatments expl
17 line (when PAH is mild) and is normalized by dichloroacetate and imatinib, which both also regress me
18 pathy induced by the chemotherapeutic agents dichloroacetate and paclitaxel or HIV envelope protein g
19                                 In MCT rats, dichloroacetate, at therapeutic levels in the RV, reduce
20   Stimulation of pyruvate dehydrogenase with dichloroacetate caused a 50% decrease in plasma lactate
21  interest among the public and scientists in dichloroacetate (DCA) as a potential anticancer drug.
22           The mitochondrial kinase inhibitor dichloroacetate (DCA) has recently received attention in
23 ogical activation of PDH by cell exposure to dichloroacetate (DCA) increased production of hyperpolar
24                                              Dichloroacetate (DCA) is an anticancer agent that can re
25 ogenase kinase (PDK) inhibitor/PDH activator dichloroacetate (DCA) normalizes HPMC metabolism, reduce
26 yruvate dehydrogenase kinase inhibition with dichloroacetate (DCA) of stunned myocardium in conscious
27 e investigated the effect of the orphan drug dichloroacetate (DCA) on survival in an animal model of
28                  Inhibiting PDK3 activity by dichloroacetate (DCA) or siRNA-mediated attenuation was
29                                              Dichloroacetate (DCA) stimulates pyruvate dehydrogenase
30        Hearts remained untreated or received dichloroacetate (DCA) to activate PDH and increase subst
31  those administered the potential neurotoxin dichloroacetate (DCA) was investigated using an intermed
32                                              Dichloroacetate (DCA), a compound capable of shifting me
33 bovine embryos from day 5 in the presence of dichloroacetate (DCA), a pyruvate analog that increases
34 us studies have found that administration of dichloroacetate (DCA), an agent that reduces lactic acid
35               However, in contrast to sodium dichloroacetate (DCA), these PDHK inhibitors did not low
36                                              Dichloroacetate (DCA), which is known to increase pyruva
37 uvate dehydrogenase complex (PDC) activator, dichloroacetate (DCA), would blunt activation of FOXO ge
38 inal DW-motif in inhibition of human PDK2 by dichloroacetate (DCA).
39 ific for pyruvate and its synthetic analogue dichloroacetate (DCA).
40     PDK3 was poorly inhibited by pyruvate or dichloroacetate (DCA).
41 infusion of intralipid + oral PDC activator, dichloroacetate (DCA).
42 veral commonly used antiproliferative drugs, dichloroacetate did not prevent vessel re-endothelializa
43    Activation of pyruvate dehydrogenase with dichloroacetate does not ameliorate the impairment of wh
44 Wistar rats: (1) controls, (2) rats in which dichloroacetate enhanced pyruvate dehydrogenase flux, an
45                     The animals treated with dichloroacetate had a larger contractile response to dob
46 avenous infusion with saline (CD and HFD) or dichloroacetate (HFD+DCA).
47 ly, we demonstrate that artesunate, CoA, and dichloroacetate improve TfR1 palmitoylation and decrease
48 and oxygen consumption rate were reversed by dichloroacetate (in RVfib and in vivo) or siRNA targetin
49                                              Dichloroacetate increased carbohydrate oxidation and the
50                                              Dichloroacetate increased resting pyruvate dehydrogenase
51                                     In vivo, dichloroacetate increased the rate of [1-(13)C]acetylcar
52    However, pyruvate dehydrogenase activator dichloroacetate infusion into the AP or NTS that enhance
53                                              Dichloroacetate inhibits this kinase, thus enhancing PDH
54  its active site, and the pyruvate analogue, dichloroacetate, led to 16-fold more ADP than ATP being
55 vity data suggest that compounds AZD7545 and dichloroacetate lock PDK4 in the open and the closed con
56 asing glucose and insulin levels or by using dichloroacetate on the response to ischemia and reperfus
57 ating the mice with the metabolic regulators dichloroacetate or C75 that increase the influx of carbo
58 ) of 2.5) and to dehydrogenase activation by dichloroacetate or cAMP (twofold increase for each).
59    Monocrotaline rats were treated with oral dichloroacetate or daily imatinib injections.
60             Pharmacologic PDK2 blockade with dichloroacetate or lentiviral PDK2 knockdown prevented D
61 te, the activator of pyruvate dehydrogenase, dichloroacetate, or the inhibitors of NAD(+) catabolism,
62 lso aimed to identify the mechanism by which dichloroacetate overcomes this "acetyl group deficit".
63                                     Further, dichloroacetate prevented myocardial hypertrophy.
64                                              Dichloroacetate raised baseline lCMR(glc) throughout the
65 rmacologic rerouting of glucose carbons with dichloroacetate reduced sialylation, viral replication,
66 drogenase kinase 4 (PDK4) or inhibition with dichloroacetate reduced the up-regulation of Atoh1 mRNA
67          Twenty-eight days of treatment with dichloroacetate restored PDH flux to normal levels (0.01
68 ed from double-knockout mice with acetate or dichloroacetate restored stem cells.
69                 Moreover, the PDK4 inhibitor dichloroacetate reversed chemoresistance to sorafenib or
70                                              Dichloroacetate reversed the impairment of insulin-stimu
71 yruvate dehydrogenase kinase (PDK) inhibitor dichloroacetate reverses dysregulated hepatocyte metabol
72  the pyruvate dehydrogenase kinase inhibitor dichloroacetate sharply suppressed B cell proliferation
73  inhibition of glycolytic reprogramming with dichloroacetate significantly impairs macrophage migrati
74                                     In vitro dichloroacetate stimulated glucose and lactate oxidation
75 pyruvate dehydrogenase complex activation by dichloroacetate, the present study examined whether ther
76               The treatment of diabetes with dichloroacetate therefore restored the balance of myocar
77 (hydroxymethyl)phenols via their derived bis(dichloroacetates) using hydrogen peroxide as a mild oxid
78 DK (pyruvate dehydrogenase kinase) inhibitor dichloroacetate was started 7 days post-MCT.
79 oward different drugs, paclitaxel and sodium dichloroacetate, was distinguished in the conjoint analy
80  nucleophilic substitution reaction of alkyl dichloroacetates with nitroarenes react with Michael acc
81 ore whether or not increasing PDH flux, with dichloroacetate, would restore the balance of substrate