ライフサイエンスコーパス: diencephalic

1 ral ventricles, 3.4% large hemispheric, 6.0% diencephalic, 4.3% corticospinal tract), 72.2% had spina

2 Tumors were infratentorial (102), diencephalic (53), and hemispheric (39); 47% required ve

3 e mammillothalamic tract to model aspects of diencephalic amnesia and assessed the impact of these le

4 el insights into the functional pathology of diencephalic amnesia and have implications for the aetio

5 Diencephalic amnesia can be as debilitating as the more

6 lationship between temporal lobe amnesia and diencephalic amnesia depends on determining the role of

7 While most accounts of diencephalic amnesia emphasize the functional importance

8 Compared with the former, the causes of diencephalic amnesia have remained elusive.

9 r, the reasons for the severe memory loss in diencephalic amnesia remain unknown.

10 We suggest that a core element of diencephalic amnesia stems from the information loss in

11 primary sites of neuropathology in cases of diencephalic amnesia such as Wernicke Korsakoff Syndrome

12 A rodent model of diencephalic amnesia, pyrithiamine-induced thiamine defi

13 the anterior thalamic nuclei at the heart of diencephalic amnesia.

14 y responsible for a similar loss of memory, "diencephalic" amnesia.

15 tion, Phox2a(+) neurons were observed within diencephalic and brainstem nuclei that regulate behavior

16 Significant increases in diencephalic and brainstem serotonin transporter binding

17 The purpose of this study was to identify diencephalic and brainstem sites active during exercise

18 etwork linking ventral striatal opioids with diencephalic and brainstem structures.

19 selectively affected mesencephalic cultures; diencephalic and C6 glioma cells were not affected by DA

20 effect on any parameters examined in primary diencephalic and C6 glioma cultures.

21 (ii) Do temporal lobe, diencephalic and frontal lobe amnesias differ?

22 and cognition seems reflected in reciprocal diencephalic and limbic activation with solvable and uns

23 studies have implicated the majority of the diencephalic and mesencephalic nuclei in electrosensory,

24 enes to be induced by FGF8 in wild-type E9.5 diencephalic and midbrain explants treated with FGF8-soa

25 osis, arising in glial cells surrounding the diencephalic and rhombencephalic ventricles just before

26 drome spectrum with the first description of diencephalic and striatal neuropathology.

27 Diencephalic and telencephalic astrocytes, from both chi

28 tively, they are principally responsible for diencephalic and temporal lobe amnesia.

29 he anterior neural plate into telencephalic, diencephalic, and eye-forming territories.

30 by transplanting dissociated telencephalic, diencephalic, and mesencephalic cells of E14 mouse embry

31 dendrocytes incorporated into telencephalic, diencephalic, and mesencephalic regions and assumed phen

32 he common core symptoms of temporal lobe and diencephalic anterograde amnesia.SIGNIFICANCE STATEMENT

33 expressing neurons increased slightly in the diencephalic area of old animals and in fasted animals,

34 re frequently the cerebellum, brainstem, and diencephalic areas.

35 ich temporal lobe seizures disrupt brainstem-diencephalic arousal systems, leading indirectly to depr

36 propagation were abolished by melatonin, as diencephalic astrocytes acquired more telencephalon-like

37 Diencephalic astrocytes are sites of action, at least in

38 stimulated an increased number of fetal rat diencephalic astrocytes to progress through G1/S, and th

39 However, waves meandered among mouse diencephalic astrocytes, taking heterogeneous paths at v

40 imilar to the 23% increase observed in chick diencephalic astrocytes.

41 Mouse diencephalic astrocytic calcium waves spread to an area

42 to the dMT, including brainstem, cerebellar, diencephalic, basal ganglia, and cortical regions involv

43 recommand nucleus (PCN) at the mesencephalic-diencephalic border and the ventroposterior nucleus (VP)

44 ventral telencephalic domain adjacent to the diencephalic border.

45 s that occupied only a part of certain inter-diencephalic boundaries, fiber tracts were present withi

46 ble for formation of an intact telencephalic-diencephalic boundary and for preventing the abnormal po

47 ssion in thalamus and prethalamus, the major diencephalic brain areas flanking the ZLI.

48 However, the ontogeny of these diencephalic brain nuclei has not to this date been exam

49 Regional differences in diencephalic cell density were lost, the diencephalon/me

50 subthalamic nucleus (STN) is a glutamatergic diencephalic cell group that develops in the caudal hypo

51 by tracing the afferent connectivity of this diencephalic cell population.

52 cephalon) revealed a unique role for Isl1 in diencephalic cells bordering the internal capsule for th

53 d for preventing the abnormal positioning of diencephalic cells in the dorsal telencephalon.

54 nule cells share a lineage with cortical and diencephalic cells, pointing toward a common lineage tha

55 We observed occasional cells with diencephalic character in the Foxg1 (forkhead box)-expre

56 As described previously, the diencephalic complex of the central posterior thalamic n

57 dentified for the forebrain and midbrain and diencephalic components of the ascending auditory pathwa

58 may compensate for inefficient corticolimbic-diencephalic components.

59 rise within a contiguous field separate from diencephalic CPe, also exhibited different patterns of a

60 Diencephalic DA-ir groups were detected in the prethalam

61 is also early posterior cingulate cortex and diencephalic damage.

62 Diencephalic defects underlie an array of neurological d

63 unction, but those with additional limbic or diencephalic deficits were most affected; 60% of these p

64 retinoic acid (RA) signaling is involved in diencephalic development at late stages of embryonic dev

65 r normal Pax-6 protein is required for early diencephalic development by examining morphology, precur

66 We report that disruption of diencephalic development by Pax6 deletion results in a t

67 ain) was disrupted, supporting the idea that diencephalic development is abnormal from very early in

68 role for both GCN5 and RA signaling in early diencephalic development, and elucidate a novel molecula

69 Pax-6 may also control some aspects of diencephalic differentiation, but its mutation in Small-

70 xpression in the ZLI alone is sufficient for diencephalic differentiation.

71 a, confining expression to a discrete dorsal diencephalic domain.

72 l types and cell states arising from various diencephalic domains.

73 Meso-diencephalic dopaminergic neurons are known to modulate

74 the activity of reticulospinal neurons, meso-diencephalic dopaminergic neurons control the very last

75 m motor circuits.SIGNIFICANCE STATEMENT Meso-diencephalic dopaminergic neurons play a key role in mod

76 otpb gene that drove specific expression in diencephalic dopaminergic neurons, although it did not s

77 ctum, and pituitary are the major targets of diencephalic dopaminergic neurons.

78 all patients and 89% of those with limbic or diencephalic dysfunction.

79 a 63-year-old man with clinical criteria for diencephalic encephalitis with sleepiness, cataplexy, hy

80 Genetic lineage tracing shows that specific diencephalic ependymo-radial glial (ERG) progenitor cell

81 Last, we demonstrate that the diencephalic expansion and transcriptional defects seen

82 exencephalic phenotype, exhibit significant diencephalic expansion, decreased diencephalic RA signal

83 Diencephalic explants from transgenic mice expressing en

84 Later in embryogenesis its diencephalic expression becomes more restricted.

85 we show that Shh/Gli2 signaling controls the diencephalic expression of Bone morphogenetic protein 4

86 .5 Small-eye mice revealed discrete zones of diencephalic expression that had similar relative positi

87 and telencephalon are reduced or absent and diencephalic fates expand to the front of the brain.

88 Hypothalamic and diencephalic groups were detected and, in particular, th

89 The connectivity between diencephalic gustatory centers and the telencephalon was

90 for memory, and consequently indicates that diencephalic-hippocampal models of memory should be exte

91 onal hormonal or MRI abnormalities indicated diencephalic-hypothalamic involvement in 34% of the pati

92 chus, the dorsolateral pallium (DL) receives diencephalic inputs representing electrosensory input ut

93 cephalon and diencephalon, the telencephalic/diencephalic junction (TDJ), is often indistinct, and th

94 te transections of the neuroaxis at the meso-diencephalic juncture.

95 expression in the brain, we find that early diencephalic left-right asymmetry also requires Southpaw

96 southpaw, that is required for visceral and diencephalic left-right asymmetry.

97 akoff syndrome (WKS) culminates in bilateral diencephalic lesion and severe amnesia.

98 ne deficiency (PTD), was used to investigate diencephalic-limbic interactions.

99 minating posterior (hindbrain) and anterior (diencephalic) lineage markers.

100 complete resection (OR = 15.50, p = 0.0009), diencephalic location (OR = 12.2, p = 0.013), and high-g

101 ions of the NPY and LHRH systems may involve diencephalic loci.

102 These findings support models of diencephalic memory mechanisms that require hippocampal

103 about interactions between temporal lobe and diencephalic memory systems.

104 ula, preglomerular nuclei, and several other diencephalic, mesencephalic, and rhombencephalic regions

105 g a "subcortical visual shell" overlying the diencephalic-mesencephalic border.

106 ransfer, we show that the positioning of the diencephalic-mesencephalic boundary (DMB) requires Engra

107 factory bulbs hypoplasia, and anomaly of the diencephalic-mesencephalic junction with abnormal cortic

108 no obvious alterations in expression at the diencephalic midline.

109 However, the mechanisms that regulate diencephalic morphogenesis and the involvement of RA sig

110 In Small-eye mice, diencephalic morphology was abnormal at all the embryoni

111 ur findings strongly suggest activation of a diencephalic network that participates in behavioral res

112 basal hypothalamic regions, and the distinct diencephalic neuromeres could be analyzed on the basis o

113 ic system is the orthopedia (otp)-expressing diencephalic neuronal population that constitutes the do

114 primate mammalian species, telencephalic and diencephalic neurons originate from their respective loc

115 n thyrotropin-releasing hormone in fetal rat diencephalic neurons, their localization and transcripti

116 To broaden our understanding of diencephalic NMDA-R participation in other functions, we

117 with holoprosencephaly in humans, regulates diencephalic Nodal activity during initial establishment

118 subdivisions and nucleus taenia); (2) other diencephalic nuclei (centroposterior, glomerular, and an

119 entral hypothalamus and a disorganization of diencephalic nuclei and axonal tracts.

120 The right habenula and posterior tuberculum (diencephalic nuclei) receive convergent inputs from rest

121 l complex differentially influences adjacent diencephalic nuclei, the left and right habenulae, which

122 anesthetics act on one or more brainstem or diencephalic nuclei, with suppression of cortex and spin

123 subpallial telencephalic areas, and in some diencephalic nuclei.

124 ely labeled dopaminergic neurons in a caudal diencephalic nucleus (posterior tuberculum [PT]).

125 any more cells are present in DL than in the diencephalic nucleus that provides it with sensory input

126 concentrated in and along the margins of the diencephalic optic tract and essentially absent from its

127 se superficially in the middle stream of the diencephalic optic tract.

128 presented with isolated or combined limbic, diencephalic or brainstem dysfunction, and four with oth

129 should be suspected in patients with limbic, diencephalic or brainstem dysfunction, MRI abnormalities

130 ow-up, 95% of the patients developed limbic, diencephalic or brainstem encephalopathy.

131 tes of isolated hypothalamic, but not dorsal diencephalic or cerebellar cells.

132 In additional experiments, specific diencephalic or limbic forebrain nuclei were microinject

133 zona limitans intrathalamica (ZLI), the mid-diencephalic organizer.

134 The unexpected extra-diencephalic origin of dLGN-INs sets them apart from GAB

135 However, the major afferents to the Vv were diencephalic, particularly those originating from the ro

136 s specifically related to early-stage limbic-diencephalic pathology, and that non-mnemonic impairment

137 y both unique and redundant functions during diencephalic patterning.

138 s that constitutively add new neurons (e.g., diencephalic population 5/6).

139 ojection from the posterior tuberculum (TPp; diencephalic populations DC2 and DC4) to the subpallium

140 ed in isthmal (nucleus praeeminentialis) and diencephalic (posterior thalamic) nuclei.

141 -6 is required for the correct regulation of diencephalic precursor proliferation.

142 ted to both retinas, bordered posteriorly by diencephalic precursors expressing mariposa.

143 e that movement of a median subpopulation of diencephalic precursors separates retinal precursors int

144 trula including prechordal plate and ventral diencephalic precursors.

145 t the main route of transmission consists of diencephalic (preglomerular complex; PG) glutamatergic i

146 environment and anatomical deficiency in the diencephalic preoptic area, where the optic chiasm norma

147 ects on these cells; the inputs from the two diencephalic prepacemaker nuclei, PPnC and PPnG, which r

148 WNT7b is expressed in cerebral cortical and diencephalic progenitor cells.

149 ontributions from multiple telencephalic and diencephalic progenitor domains.

150 While diencephalic progenitors from R-cadherin-expressing regi

151 Furthermore, diencephalic progenitors that integrate heterotopically

152 omplex retroviral library was used to infect diencephalic progenitors.

153 cal TH-ir neurons but may include input from diencephalic projections as well.

154 We estimated diencephalic proliferative rates after labelling with br

155 pons, and medulla oblongata) and cerebellum (diencephalic prosomere 1 through to rhombomere 11) play

156 d the alar hypothalamus, and caudally by the diencephalic prosomere p3.

157 ignificant diencephalic expansion, decreased diencephalic RA signaling, and increased diencephalic WN

158 ation of transitin mRNA is best shown in the diencephalic radial glia, as well as cerebellar Bergmann

159 es synthesis of methionine enkephalin in the diencephalic region of the brain.

160 ificant progress in the comprehension of the diencephalic region of Xenopus and show that the organiz

161 not preclude the development of a degree of diencephalic regionalization resembling that in normal m

162 y, suggesting that Bhlhb4 may have a role in diencephalic regionalization.

163 is double dissociation shows that the limbic-diencephalic regions damaged in amnesia and the neostria

164 ytes, particularly between telencephalic and diencephalic regions in both species.

165 mu-receptor mRNA was expressed in different diencephalic regions including the preoptic area, the be

166 ent in subpallial telencephalic regions, and diencephalic regions of the preoptic area, thalamus, and

167 ng of limbic forebrain regions from midbrain/diencephalic regions.

168 acquisition of identity for these important diencephalic regions.

169 tes at a left-to-medial site from the dorsal diencephalic roof, becomes displaced in position.

170 amus and dorsal thalamus, and functions as a diencephalic signaling center.

171 E, and that characteristic telencephalic and diencephalic signaling centers, the cortical hem and zon

172 evelopment.SIGNIFICANCE STATEMENT Changes in diencephalic size and shape, as well as SNPs associated

173 of RA signaling that is required to restrict diencephalic size during early forebrain development.SIG

174 en despite the absence of medial temporal or diencephalic strokes.

175 The habenula is a dorsal diencephalic structure consisting of medial and lateral

176 d herald a new understanding of why specific diencephalic structures are vital for memory.

177 it2 expression is strong in anterior ventral diencephalic structures but is absent from the ventral m

178 the neuroanatomy of medial temporal lobe and diencephalic structures important for memory, multiple m

179 obe amnesia, yet the precise contribution of diencephalic structures to memory processes remains elus

180 ield into diencephalic territory and loss of diencephalic structures, indicating a role for Rtk1 in p

181 mRNAs showed substantial enrichment in basal diencephalic structures, particularly the hypothalamus,

182 ates, its expression is enriched in specific diencephalic structures, where the highest levels are ob

183 lary bodies, components of the corticolimbic-diencephalic subsystem subserving functionally later dev

184 ty of components of the extended hippocampal-diencephalic system to memory performance in MS patients

185 leus of channel catfish project to different diencephalic targets, single cells were intracellularly

186 mispositioned and appeared to arise from the diencephalic-telencephalic boundary.

187 1-positive telencephalic- and Foxg1-negative diencephalic territories.

188 tor leads to expansion of the eye field into diencephalic territory and loss of diencephalic structur

189 Diencephalic TH-ir neurons in the periventricular poster

190 c neurons in each of the major forebrain and diencephalic TH-positive cell groups expressed zDJ-1.

191 sustained support initially from limbic then diencephalic then cortical circuits, they become progres

192 cephalon is, in fact, expression in adjacent diencephalic tissue, which expresses many of the same ge

193 he other was the absence of the dorsoventral diencephalic tract in Alligator which lacks a pineal gla

194 The constructed detailed diencephalic transcription factor gene expression map fu

195 This phenotype was recapitulated by diencephalic transections that removed the dopaminergic

196 Twelve patients (18%), predominantly with diencephalic tumor location, died of a specific medical

197 ntorial tumors (P = .008), optic pathway and diencephalic tumors (P = .012), and subtotal resection o

198 Patients with diencephalic tumors had inferior FFS and OS compared wit

199 are particularly required for patients with diencephalic tumors.

200 e hypothalamic cells derive from the rostral diencephalic ventral midline, lie above the prechordal m

201 d macrophage/microglia enrichment around the diencephalic ventricle.

202 A neurons precede RGC axons into the lateral diencephalic wall and like RGC axons also express GAP-43

203 ignaling required for entry into the lateral diencephalic wall to form the optic tracts.

204 nteraction with guidance cues in the lateral diencephalic wall, suggesting possible involvement of PK

205 sed diencephalic RA signaling, and increased diencephalic WNT and SHH signaling.