ライフサイエンスコーパス: dietary cholesterol

1 ires NPC1 protein; NPC1L1 mediates uptake of dietary cholesterol.

2 onse that prevents absorption of biliary and dietary cholesterol.

3 s, and its activity is strongly modulated by dietary cholesterol.

4 total animal fat, saturated animal fat, and dietary cholesterol.

5 ial LDL-cholesterol elevation from the added dietary cholesterol.

6 dex and a greater intake of total energy and dietary cholesterol.

7 the role of LXR alpha as the major sensor of dietary cholesterol.

8 e in regulating the percentage absorption of dietary cholesterol.

9 turated and polyunsaturated fatty acids, and dietary cholesterol.

10 turated and monounsaturated fatty acids, and dietary cholesterol.

11 apoB-containing lipoproteins in response to dietary cholesterol.

12 dendritic cells and increased in response to dietary cholesterol.

13 m cholesterol levels that can be restored by dietary cholesterol.

14 2013 for prospective studies that quantified dietary cholesterol.

15 ation of new fat cells upon overfeeding with dietary cholesterol.

16 he human diet and eggs are a major source of dietary cholesterol.

17 d by SREBP2, which responds to reductions in dietary cholesterol.

18 t the normal stimulation of CETP activity by dietary cholesterol.

19 reduced and declined further upon feeding of dietary cholesterol.

20 energy), saturated fatty acids (14.2%), and dietary cholesterol (492 mg/d) were similar to amounts s

21 The mass of dietary cholesterol absorbed (mg/d per 100 g body weight

22 inversely correlated with the percentage of dietary cholesterol absorbed (r = -0.99, P < 0.0008).

23 A plot of total daily mass of dietary cholesterol absorbed versus the percentage by we

24 dose-dependent decrease in the percentage of dietary cholesterol absorbed.

25 and inversely correlated with the percentage dietary cholesterol absorption (r = -0.63, P < 0.0001).

26 apolipoprotein E (apoE) in the regulation of dietary cholesterol absorption and biliary cholesterol e

27 In the present study, we showed that dietary cholesterol absorption and commensal recognition

28 no significant suppression of the percentage dietary cholesterol absorption and increased gallbladder

29 y therefore throw light on regulation of net dietary cholesterol absorption and lead to an advancemen

30 there is a molecular pathway that regulates dietary cholesterol absorption and sterol excretion by t

31 tion and physical-chemical factors affecting dietary cholesterol absorption have been extensively inv

32 es have suggested phospholipid inhibition of dietary cholesterol absorption through the gastrointesti

33 The regulation of dietary cholesterol absorption was examined in C57BL/6 a

34 Circulating cholesterol is the balance among dietary cholesterol absorption, hepatic synthesis and se

35 sing hepatic Abcg5/8 expression and limiting dietary cholesterol absorption, T39 deficiency inhibits

36 tary triglyceride is necessary for efficient dietary cholesterol absorption.

37 as originally thought to be its mediation of dietary cholesterol absorption.

38 sporters to participate in the regulation of dietary cholesterol absorption.

39 se changes correlated with the percentage of dietary cholesterol absorption.

40 erol into the bile and suppressed percentage dietary cholesterol absorption.

41 esterol-lowering drug that blocks intestinal dietary cholesterol absorption.

42 to assess the relation between the change in dietary cholesterol (adjusted for dietary fatty acids) a

43 Dietary cholesterol also caused an increase in biliary c

44 Addition of dietary cholesterol also increased atherosclerosis (P<0.

45 Dietary cholesterol also statistically significantly inc

46 estern diet will contain about 250-500 mg of dietary cholesterol and about 200-400 mg of non-choleste

47 iet will contain approximately 250-500 mg of dietary cholesterol and approximately 200-400 mg of non-

48 a, lose their ability to respond normally to dietary cholesterol and are unable to tolerate any amoun

49 Dietary cholesterol and bile acids, particularly UDCA, i

50 Dietary cholesterol and cholate produced discrete gene e

51 nse of biliary cholesterol secretion to high dietary cholesterol and contributes to cholesterol galls

52 t, SREBP-1c gene expression was increased by dietary cholesterol and decreased by cholesterol depleti

53 d by the ability of bile acids to solubilize dietary cholesterol and essential nutrients and to promo

54 94 reporting quantitative data on changes in dietary cholesterol and fat and corresponding changes in

55 To study the effects of dietary cholesterol and fat upon expression of the human

56 ere its expression is regulated by estrogen, dietary cholesterol and fat, and controls murine plasma

57 n diet, consistent with predictions based on dietary cholesterol and fat.

58 aceous glands have the capacity to sequester dietary cholesterol and fatty acids that may have import

59 ur findings revealed a new mechanism linking dietary cholesterol and humoral immune responses centere

60 as no association between egg consumption or dietary cholesterol and increased risk of incident T2D.

61 e in decreasing the percentage absorption of dietary cholesterol and increasing biliary cholesterol e

62 intestine, where T(RM) cells interface with dietary cholesterol and maintain a heightened state of a

63 spectively examined the associations between dietary cholesterol and major fatty acids, and risk of P

64 Dietary cholesterol and monounsaturated and polyunsatura

65 Although eggs are important sources of dietary cholesterol and other nutrients, little is known

66 target for therapies that inhibit uptake of dietary cholesterol and reduce the incidence of cardiova

67 is study examined the independent effects of dietary cholesterol and saturated fat on LDL concentrati

68 The positive relation between dietary cholesterol and serum total and low-density-lipo

69 mouse tissues in an LXR-dependent manner by dietary cholesterol and synthetic agonists for both LXR

70 he relative contributions of dietary fat and dietary cholesterol and their interaction on the develop

71 macrophage foam-cell formation, in absorbing dietary cholesterol, and in supplying cholesteryl esters

72 lgus monkeys, a species highly responsive to dietary cholesterol, and less responsive African green m

73 Pcsk9 expression is down-regulated by dietary cholesterol, and mutations in Pcsk9 have been as

74 ent a decline in dietary fat, saturated fat, dietary cholesterol, and serum cholesterol.

75 etween consumption of egg, a major source of dietary cholesterol, and stroke.

76 AT2 has an important role in the response to dietary cholesterol, and suggest that ACAT2 inhibition m

77 essure, smoking status, alcohol consumption, dietary cholesterol, and total calorie intake, a differe

78 These results suggest that, in response to dietary cholesterol, apoE may play a critical role in de

79 d here, intakes of saturated fatty acids and dietary cholesterol are generally positively correlated

80 AT2 with antisense oligonucleotides prevents dietary cholesterol-associated hepatic steatosis both in

81 aimed to establish a mouse model of reduced dietary cholesterol availability from maternal milk and

82 ic CYP39A1 mRNA do not change in response to dietary cholesterol, bile acids, or a bile acid-binding

83 cid synthesis, was elevated, unresponsive to dietary cholesterol, but repressed normally by dietary c

84 Second, we investigated whether dietary cholesterol caused an increase in brain choleste

85 riptomic analysis of the lungs revealed that dietary cholesterol caused upregulation of genes involve

86 s and females in this species responded to a dietary cholesterol challenge.

87 scribed the data across the full spectrum of dietary cholesterol changes studied (0-1500 mg/d).

88 Each additional 300 mg of dietary cholesterol consumed per day was significantly a

89 Dietary cholesterol consumption and intestinal cholester

90 re no longer significant after adjusting for dietary cholesterol consumption.

91 and hepatic cholesterol levels to changes in dietary cholesterol content.

92 s paper, we elucidate the mechanism by which dietary cholesterol controls epithelial follicle stem ce

93 ontaining two large eggs per day with 581 mg dietary cholesterol/d also raised LDL- and HDL-cholester

94 in LDL cholesterol for an increase of 100 mg dietary cholesterol/d were 1.90, 4.46, and 4.58 mg/dL fo

95 aining 300 g shrimp/d, which supplied 590 mg dietary cholesterol/d, significantly increased low-densi

96 to compare the effect of an equal amount of dietary cholesterol derived from shrimp or egg on the pl

97 Dietary cholesterol did not statistically significantly

98 ough our data confirm previous findings that dietary cholesterol does not directly affect cholesterol

99 that inhibition of hepatic ACAT2 can prevent dietary cholesterol-driven hepatic steatosis in mice.

100 These lipid-soluble molecules derived from dietary cholesterol easily penetrate the brain and act t

101 Saturated fat, not dietary cholesterol, elevates LDL cholesterol.

102 ene expression was not altered by changes in dietary cholesterol flux.

103 In contrast, increasing dietary cholesterol from 0.02% to 0.5% in C57BL/6 apoE k

104 Increasing dietary cholesterol from 0.02% to 0.5% in C57BL/6 wild-t

105 Although dietary cholesterol from eggs has been a focus of dietar

106 Transport of dietary cholesterol from endocytic organelles to the end

107 to address questions about the relevance of dietary cholesterol guidance for heart health.

108 We show that dietary cholesterol had an adverse effect on memory reca

109 Furthermore, dietary cholesterol had comparable effects on total plas

110 Dietary cholesterol has been suggested to increase the r

111 al data and animal studies, both obesity and dietary cholesterol have been associated with coronary a

112 The hamster metabolizes and transports dietary cholesterol in a similar manner to humans, with

113 These findings emphasize the safety of dietary cholesterol in inflammatory diseases and point t

114 r, providing insight into the effect of high dietary cholesterol in intestinal immunity.

115 PCSK9 expression is regulated by dietary cholesterol in mice and cellular sterol levels i

116 newborn mice and decreases the absorption of dietary cholesterol in surviving adults.

117 D36 KO exhibited significant accumulation of dietary cholesterol in the intestinal lumen at the end o

118 Absorption of dietary cholesterol in the proximal region of the intest

119 protein (NPC1L1) mediates the absorption of dietary cholesterol in the proximal region of the intest

120 reduced low-density lipoprotein response to dietary cholesterol in the setting of a moderate fat int

121 n, BMI, dietary intervention (in girls), and dietary cholesterol (in boys) were significant in determ

122 However, in both Het and Tg+KO mice, dietary cholesterol increased bile acid pool size (36% a

123 We confirmed previous findings that dietary cholesterol increased mouse Cyp7a1 activity in H

124 Whereas in wild-type mice, the increase in dietary cholesterol increased the hepatic excretion of b

125 However, whether dietary cholesterol increases inflammatory marker levels

126 Dietary cholesterol induced a significant 3-fold increas

127 atic macrophages in this model revealed that dietary cholesterol induced a tissue repair and regenera

128 Specifically we found that: 1) high dietary cholesterol induces aneuploidy in mice, satisfyi

129 ignaling pathway, combined with decreases in dietary cholesterol, induces the regression of atheroscl

130 est expression in adrenal gland with partial dietary cholesterol induction of CETP mRNA and plasma ac

131 To determine whether dietary cholesterol influenced the phosphorylation state

132 conflicting evidence on the extent to which dietary cholesterol influences cholesterol metabolism.

133 Our model suggests that dietary cholesterol initiates intestinal inflammation in

134 Dietary cholesterol, insoluble fiber, body mass index, a

135 a reference for clinicians on how changes in dietary cholesterol intake affect circulating cholestero

136 he dose-response relation between changes in dietary cholesterol intake and changes in lipoprotein-ch

137 liver is the central organ that responds to dietary cholesterol intake and facilitates the release a

138 a 10 cigarette/d smoking habit, and reducing dietary cholesterol intake by 100 mg/d on average would

139 When dietary cholesterol intake is kept constant, some long-c

140 Dietary cholesterol intake was associated with the risk

141 ed age, smoking status, total energy intake, dietary cholesterol intake, percentages of energy obtain

142 Dietary fat and dietary cholesterol interact synergistically to induce t

143 About 50-60% of the dietary cholesterol is absorbed and retained by the norm

144 Approximately 50-60% of dietary cholesterol is absorbed and retained by the norm

145 ar and MM models indicate that the change in dietary cholesterol is modestly inversely related to the

146 A reduction in dietary cholesterol is recommended to prevent cardiovasc

147 The molecular mechanisms by which dietary cholesterol is trafficked within cells are poorl

148 Reduction in dietary cholesterol is widely recommended for the preven

149 When challenged with excess dietary cholesterol, Lats2-CKO mice manifested more seve

150 Increased dietary cholesterol led to significant reductions in bra

151 ated in the ACAT2(-/-) mice, irrespective of dietary cholesterol level.

152 r to induce equivalent hypercholesterolemia, dietary cholesterol levels were 50% lower than was fed t

153 ly correlated with daily cholesterol intake, dietary cholesterol mass absorption, and liver cholester

154 There are limited data that dietary cholesterol may worsen macrophage accumulation i

155 gnaling pathway protects the body from toxic dietary cholesterol metabolites, and, by extension, PXR

156 Dietary cholesterol (mg/day) or egg consumption (number/

157 In multivariate regression models, dietary cholesterol (milligrams per 1000 kilocalories),

158 al fat (negative), saturated fat (negative), dietary cholesterol (negative), polyunsaturated fat (pos

159 However, the effect of dietary cholesterol on adipose tissue has not been widel

160 review summarizes current evidence regarding dietary cholesterol on adipose tissue macrophage accrual

161 We investigated the effect of increasing dietary cholesterol on bile acid pool sizes and the regu

162 In general populations, the effects of dietary cholesterol on blood cholesterol concentrations

163 The effects of dietary cholesterol on brain amyloid precursor protein (

164 The authors examine the effects of dietary cholesterol on CVD risk in healthy adults by usi

165 e useful to identify the relative effects of dietary cholesterol on CVD risk.

166 raw any conclusions regarding the effects of dietary cholesterol on CVD risk.

167 In the adult mouse, dietary cholesterol or colestipol induce cholesterol 7al

168 Whether dietary cholesterol or egg consumption is associated wit

169 The associations of dietary cholesterol or egg consumption with incident CVD

170 Among US adults, higher consumption of dietary cholesterol or eggs was significantly associated

171 vels rise following increased consumption of dietary cholesterol or saturated and trans-monounsaturat

172 y dimorphic and do not change in response to dietary cholesterol or to changes in bile acid pool size

173 l conditions, including diabetes, feeding of dietary cholesterol, or statin treatment.

174 018 mmol/L for each 10 mg/4.2 MJ decrease in dietary cholesterol (P<.05).

175 atty acids; intake of complex carbohydrates; dietary cholesterol; plasma triacylglycerol; and age wer

176 Taken together, dietary cholesterol promoted IAV morbidity via exaggerat

177 ein kinase C delta with ATP, suggesting that dietary cholesterol reduced the expression of this prote

178 Thus, in Tg+KO mice, dietary cholesterol regulates bile acid pool size, fecal

179 Dietary cholesterol regulation of cholesterol 7alpha-hyd

180 These results challenge the notion that dietary cholesterol regulation of Cyp7a1 is a major dete

181 s of HDL-cholesterol changes associated with dietary cholesterol remain uncertain.

182 Tissue-specific expression and dietary cholesterol response of CETP mRNA were determine

183 C57BL/6 animals, feeding 0.02 to 1% (wt/wt) dietary cholesterol resulted in a dose-dependent decreas

184 olecular mechanisms regulating the amount of dietary cholesterol retained by the body, as well as the

185 olecular mechanisms regulating the amount of dietary cholesterol retained in the body as well as the

186 olecular mechanisms regulating the amount of dietary cholesterol retained in the body, as well as the

187 ium and intakes of total and animal protein, dietary cholesterol, saturated fats, and heme iron and h

188 f hepatic free cholesterol concentrations by dietary cholesterol, seen only in cynomolgus monkeys, re

189 Dietary cholesterol statistically significantly increase

190 Upon feeding, dietary cholesterol stimulates S6 kinase-mediated phosph

191 Dietary cholesterol supplementation improves systemic bi

192 ng to NPC1 and NPC2, Wnt5a senses changes in dietary cholesterol supply and promotes lysosomal choles

193 Dietary cholesterol suppressed hepatic 3-hydroxy-3-methy

194 The elimination of specific dietary cholesterol target recommendations in recent gui

195 A recommendation that gives a specific dietary cholesterol target within the context of food-ba

196 e significantly more responsive to change in dietary cholesterol than concentrations in children with

197 6 wild-type mice decreased the percentage of dietary cholesterol that is absorbed by 25%, and this de

198 the amount of endogenous biliary as well as dietary cholesterol that is retained, thereby influencin

199 In addition, at high levels of dietary cholesterol the mRNA encoding SREBP-2 declined a

200 mendations for total fat, saturated fat, and dietary cholesterol, the vast majority continued to exce

201 Dietary cholesterol therapy improved sterol profiles in

202 elate partly to a limited ability to convert dietary cholesterol to bile acid.

203 cilitates the delivery of significantly more dietary cholesterol to the liver than is the case in mal

204 ssion of NCoRDeltaID in mouse liver improves dietary cholesterol tolerance in an LXRalpha-independent

205 lipid infusion and significant reduction of dietary cholesterol transport into the lymph.

206 rption in the intestine, the primary site of dietary cholesterol uptake in humans, can have profound

207 ke 1 (NPC1L1) assists in the initial step of dietary cholesterol uptake, but how cholesterol moves do

208 ed a novel protein in C. elegans involved in dietary cholesterol uptake, which we have named ChUP-1.

209 1-like 1 gene NPC1L1, which is essential for dietary cholesterol uptake.

210 ntestinal cells have been shown to transport dietary cholesterol via apoB-independent pathways, such

211 Reduction in dietary cholesterol was achieved primarily by substantia

212 Dietary cholesterol was associated with statistically si

213 st differences occurring in situations where dietary cholesterol was elevated.

214 holesterol (beta = 0.35, P = 0.002), whereas dietary cholesterol was not (beta = -0.006, P = 0.42).

215 In a secondary analysis, dietary cholesterol was not associated with incident dia

216 Dietary cholesterol was not statistically significantly

217 The change in dietary cholesterol was positively associated with the c

218 The fractional absorption of dietary cholesterol was reduced by about 50%, and biliar

219 lator of the hypercholesterolemia induced by dietary cholesterol was studied.

220 Corresponding RRs (95% CIs) for dietary cholesterol were 1.00 (reference), 1.08 (0.84, 1

221 fat, saturated fat, polyunsaturated fat, and dietary cholesterol were observed from 1988-1994 to 2007

222 view of human studies on the relationship of dietary cholesterol with blood lipids, lipoproteins, and

223 l but that the combination of high levels of dietary cholesterol with specific saturated fatty acids

224 s of cholesterol and eggs, a major source of dietary cholesterol, with carotid intima-media thickness

225 s of cholesterol and eggs, a major source of dietary cholesterol, with the risk of cognitive decline