ライフサイエンスコーパス: dietary fat

1 ed nuts, or a control diet (advice to reduce dietary fat).

2 abdominal fat distribution were modified by dietary fat.

3 or extreme restriction in the consumption of dietary fat.

4 eased energy intake and greater selection of dietary fat.

5 erol, triglycerides, and fasting glucose) to dietary fat.

6 ring involved in the homeostatic response to dietary fat.

7 representing the direct storage pathway for dietary fat.

8 s secretion of CCK by I cells in response to dietary fat.

9 ated with higher intakes of total energy and dietary fat.

10 occurred with both unsaturated and saturated dietary fat.

11 k in their ability to absorb cholesterol and dietary fat.

12 consumption of >60 kcal x kg(-1) x d(-1) of dietary fat.

13 nd differently to postprandial processing of dietary fat.

14 ic enzymes in order to control the uptake of dietary fat.

15 lipid deposition under conditions of excess dietary fat.

16 vs. white meat, and the interfering role of dietary fat.

17 DM) trial, which focused on the reduction of dietary fat.

18 c remodeling in hypoxia, but is prevented by dietary fat.

19 ave been implicated in the chemosensation of dietary fats.

20 ctivation and interleukin-1beta secretion by dietary fats.

21 ndingly complex health effects of individual dietary fats.

22 Total dietary fat (34% of energy) and other macronutrients wer

23 esizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1).

24 ntestine, called lacteals, play key roles in dietary fat absorption and the gut immune response; howe

25 n of acylglycerols by DGAT1 is important for dietary fat absorption in the intestine.

26 triacylglycerol, a key process required for dietary fat absorption into the enterocytes of the small

27 Regulation of intestinal dietary fat absorption is critical to maintaining energy

28 embrane bound acyltransferases implicated in dietary fat absorption.

29 drainage of interstitial fluids and reduced dietary fat absorption.

30 association at the cellular membrane, blocks dietary fat-accelerated tumorigenesis in vivo Our findin

31 Dietary fat accumulates in lipid droplets or endolysosom

32 ate-limiting step in the transit of absorbed dietary fat across the enterocyte is the generation of t

33 , continuous access to an optional source of dietary fat (Ad Lib; n = 12), 1-h access to an optional

34 hat we previously reported following reduced dietary fat along with PEG-leptin and exendin-4 or FGF21

35 wild-type offspring under standard maternal dietary fat amounts to test the effects of low n-6/n-3 r

36 ROP (i.e., nontasters) like and consume more dietary fat and are prone to obesity.

37 nimals are remarkably efficient in absorbing dietary fat and assimilating this energy-dense nutrient

38 pidemiologic data on the correlation between dietary fat and breast cancer have been mixed, the Women

39 Epidemiologic studies of dietary fat and breast cancer risk are inconsistent, and

40 r prostate cancer with a special emphasis on dietary fat and carbohydrate intake for modulating progn

41 etes.In the present study, we tested whether dietary fat and carbohydrate intakes influenced the asso

42 weight loss, and this effect is dependent on dietary fat and carbohydrate intakes.

43 The associations between dietary fat and cardiovascular disease have been evaluat

44 We hypothesized that dietary fat and cholesterol drive NAFLD progression to s

45 present study, we have examined the role of dietary fat and cholesterol in the initiation and progre

46 Several lines of evidence suggest that dietary fat and cholesterol may play a role in the patho

47 Taken together, our data suggest that dietary fat and cholesterol play an important role in th

48 Hepatic and metabolic effects induced by dietary fat and cholesterol together were more than twic

49 and phospholipids, intestinal absorption of dietary fat and cholesterol, and gene expression were pe

50 variation in the response of serum LDL-C to dietary fat and cholesterol.

51 aimed to test the relative contributions of dietary fat and dietary cholesterol and their interactio

52 Dietary fat and dietary cholesterol interact synergistic

53 demiological evidence on the impact of total dietary fat and fat subtypes, measured pre- and/or postc

54 mediate the absorption of a major portion of dietary fat and fat-soluble vitamin esters.

55 nce, glucose tolerance, and tissue uptake of dietary fat and glucose were assessed.

56 e results establish a new mechanism by which dietary fat and gut microbiota modulate EEC nutrient sen

57 We hypothesized that, by examining dietary fat and its food sources classified according to

58 intracellular signaling pathway that senses dietary fat and leads to fat storage remains elusive.

59 maintenance, due to the constant exposure to dietary fat and mechanical strain, and efficient uptake

60 uscle, brain, spinal cord, and tongue, while dietary fat and overnight fasting had differential effec

61 o differential exposure duration and timing, dietary fat and phytoestrogen content, or lack of sophis

62 suggest that there is no association between dietary fat and prostate cancer risk.

63 on types of dietary fat than total amount of dietary fat and recommend replacing SFAs with unsaturate

64 The association between dietary fat and risk of prostate cancer was assessed by

65 e association between the amount and type of dietary fat and subsequent weight change (follow-up weig

66 nt association between the amount or type of dietary fat and subsequent weight change in this large p

67 erminant of energy metabolism in response to dietary fat and suggest that the inhibition of this enzy

68 2) has a crucial role in the assimilation of dietary fat and the accretion of body fat in mice.

69 confidence intervals for the association of dietary fat and UL incidence.

70 r increased intake and/or status of specific dietary fats and 2) higher dietary intake or supplementa

71 The quality of dietary fats and carbohydrates consumed is more crucial

72 he rapidly increasing scientific findings on dietary fats and cardiometabolic diseases have generated

73 sis, and disease, but links between specific dietary fats and cell fates are poorly understood.

74 isk has renewed debate over the link between dietary fats and CHD.

75 n Heart Association presidential advisory on dietary fats and CVD reviews and discusses the scientifi

76 tive was to investigate associations between dietary fats and early kidney disease.

77 e induction and modulation of ferroptosis by dietary fats and indicate that endogenous ether lipids a

78 tress can prevent inflammasome activation by dietary fats and may be a strategy to reduce lipid-induc

79 are influenced by enzyme function, intake of dietary fats and sugars and whole-body metabolism, and a

80 zes the evidence on the effects of different dietary fats and their food sources on cell function and

81 Ks in fat cell maturation, storage of excess dietary fat, and body weight (BW) gain, we studied a gen

82 ny changes in symptoms of anxiety, intake of dietary fat, and exercise behavior at a mean (+/-SD) of

83 associations between total fat, subtypes of dietary fat, and food sources rich in saturated fatty ac

84 toxin (lipopolysaccharides) that occurs with dietary fat, and oral IAP supplementation prevents as we

85 ria, but neither total nor other subtypes of dietary fat are associated with high albuminuria or eGFR

86 Dietary fats are important triggers of this process, ind

87 Dietary fats are not created equally, slight differences

88 ount and the type and source of prepregnancy dietary fats are related to risk of GDM.

89 fficiently incorporates and rapidly secretes dietary fat as chylomicrons (lipoprotein particles compr

90 strongly implicates chronic inflammation and dietary fats as risk factors for cancer, the mechanisms

91 in regulating the absorption and storage of dietary fats, as well as in the development of obesity a

92 the animal-based diet support a link between dietary fat, bile acids and the outgrowth of microorgani

93 isingly, these mice absorb normal amounts of dietary fat but increase their energy expenditure.

94 These alterations are specific to dietary fat but not carbohydrate or protein.

95 Together these data show that dietary fats, by promoting changes in host bile acid com

96 Exogenous dietary fat can induce obesity and promote diabetes, but

97 ell established, it is still unclear whether dietary fat can modulate cancer risk in a predisposed po

98 s context, an intriguing possibility is that dietary fats can incorporate into membrane lipids to reg

99 vious studies showed that different types of dietary fats can modulate EtOH-induced changes in the in

100 dy was to investigate how the differences in dietary fat composition affect survival and bacterial lo

101 how these effects may be altered by varying dietary fat composition and exercise.

102 an adipose tissue is affected differently by dietary fat composition and general overfeeding in a ran

103 Dietary fat composition can affect ectopic lipid accumul

104 The importance of dietary fat composition for ectopic fat storage in human

105 notype is however variable and influenced by dietary fat composition, with the APOE4 allele associate

106 metabolism and adapts rapidly to changes in dietary fat composition.

107 However, dietary fats comprise heterogeneous molecules with diver

108 , genetic background (C57BL/6 vs. A/J mice), dietary fat concentration (27% vs. 5%), and time (2, 5,

109 In the mouth, dietary fat constituents such as mono- and diunsaturated

110 To test the hypothesis that parental dietary fat consumption during gestation and lactation i

111 ctivity under conditions of obesity and high dietary fat consumption, likely due to leptin resistance

112 bserve significant association between total dietary fat content and T2D (P-trend = 0.24), but intake

113 es to fuel interest in the potential role of dietary fat content in reducing breast cancer risk.

114 Dietary fat content probably influences both NAFLD and i

115 Consumption of dietary fat contributes to metabolic disorders, but EEC

116 Dietary fats could affect glucose metabolism and obesity

117 n = 12), 1-h access to an optional source of dietary fat daily (Daily; n = 12), or 1-h access to an o

118 over this approximately 6-week time period, dietary fats did not substantially affect responses to p

119 Whether the lipid response to dietary fat differs between normal-weight and obese pers

120 triglyceride lipase (PNLIP) is essential for dietary fat digestion in children and adults, whereas a

121 te functional PLRP2 and may have inefficient dietary fat digestion, particularly when breastfeeding i

122 on of provitamin A carotenoids to vitamin A, dietary fat effects, and the effect of genotype on the a

123 In vivo, dietary fat emulsions contain fatty acids as a result of

124 ogenous lipid mediator that is released when dietary fat enters the small intestine.

125 Dietary fat exerts a potent stimulatory effect on feedin

126 he dose of beta-carotene, and the amounts of dietary fat, fiber, vitamin A, and other carotenoids in

127 nce in underreporting error was explained by dietary fat (g), BMI, and sex.

128 Although dietary fat has been associated with prostate cancer ris

129 Health effects of dietary fats have been extensively studied for decades.

130 atory evidence suggests a plausible role for dietary fat in breast cancer pathophysiology.

131 k is a material contributor of vitamin D and dietary fat in children.

132 Erk1 or Calhm1 genes impaired preference for dietary fat in mice.

133 a statistically significant interaction with dietary fat in relation to WC and SAT (P-interaction = 0

134 uvenile gut, suggesting a potential role for dietary fat in shaping commensal microbial communities i

135 nt, some clarification regarding the role of dietary fat in T2D incidence could be provided.

136 Lipid absorption involves hydrolysis of dietary fat in the lumen of the intestine, followed by t

137 oportion of total energy intake derived from dietary fat in the symptomatic group was higher than tha

138 Our findings uncover a novel role of dietary fats in colorectal cancer metastasis and reveal

139 stasis, immune trafficking and absorption of dietary fats in the human body.

140 studies in adult and weanling rats show that dietary fat, in close association with circulating lipid

141 In conclusion, polyunsaturated dietary fat increased both survival and efficiency of ba

142 The dietary fat increased the bioaccessibility of capsaicin

143 r protein deleter mice, which fail to absorb dietary fat, increased in peroxisome proliferator activa

144 Here we show in mice that excess dietary fat induced MKP-1 overexpression in skeletal mus

145 d defects of DA and 5HT neurotransmission in dietary fat induced obese animals.

146 ts high in soy protein may help prevent high dietary fat-induced bone impairments; and the molecular

147 ion was markedly reduced in both genetic and dietary fat-induced obesity and diabetes.

148 on of PKCbeta expression could contribute to dietary fat-induced obesity and related disorders.

149 We sought to determine whether dietary fat-induced secretion of CCK is directly mediate

150 d glucose intolerance in genetic (db/db) and dietary fat-induced type 2 diabetic mice as well as in s

151 ses their recruitment and in the presence of dietary fat induces hepatosteatosis.

152 t type 2 diabetes for participants with high dietary fat intake >/=37% (GG vs. AA/AG, OR 2.36 [1.02-5

153 Dramatic changes in dietary fat intake (-61%; P<0.001 versus controls) and p

154 between the APOA5 rs964184 polymorphism and dietary fat intake (low compared with high) in the deter

155 and follow-up in anxiety symptoms (P=0.80), dietary fat intake (P=0.89), or exercise behavior (P=0.6

156 We assessed the relation of dietary fat intake (total, subtypes, and selected food s

157 Both obesity and high dietary fat intake activate the nucleotide oligomerizati

158 There is growing evidence suggesting that dietary fat intake affects the development and progressi

159 ciations between total and specific types of dietary fat intake and 1) hormone concentrations and 2)

160 Observational studies of dietary fat intake and breast cancer have reported incon

161 etary lipids and interaction effects between dietary fat intake and genetic variation on risk of GA.

162 eractions between APOE genotype and habitual dietary fat intake and modulations of fat intake on meta

163 correlate with sugar intake, independent of dietary fat intake and obesity.

164 No significant differences in dietary fat intake and physical activity levels were not

165 ctive was to examine the association between dietary fat intake and semen quality among 701 young Dan

166 ine the relative contributions of changes in dietary fat intake and use of cholesterol-lowering medic

167 was a marker of total partially hydrogenated dietary fat intake and was not associated with outcomes

168 ndings suggest that enterostatin may inhibit dietary fat intake by blocking dopamine reuptake transpo

169 Excessive dietary fat intake causes systemic metabolic toxicity, m

170 As body mass index (BMI) and dietary fat intake differed between the groups (P < 0.05

171 High dietary fat intake has been associated with increased en

172 inconsistent epidemiologic evidence whether dietary fat intake is associated with future weight chan

173 Increasing dietary fat intake is expected to improve alpha-tocopher

174 ities and information on the contribution to dietary fat intake is needed to inform dietary guideline

175 In addition, dietary fat intake may also increase circulating adropin

176 Dietary fat intake may contribute to non-Hodgkin lymphom

177 long-term changes in energy expenditure, and dietary fat intake may modify the genetic effects.

178 79 years, with no prior breast cancer, and a dietary fat intake of >= 32% of energy were randomly ass

179 The effect of change in dietary fat intake on concentrations of total cholestero

180 However, the short-term effect of dietary fat intake on the expression of these genes has

181 In summary, manipulation of dietary fat intake shows promise in the prevention and t

182 Dietary fat intake was estimated with the use of country

183 had the greatest liver tumor incidence while dietary fat intake was not associated with tumorigenesis

184 ostatin, an endogenous pentapeptide inhibits dietary fat intake when administered peripherally and ce

185 here was little evidence for associations of dietary fat intake with NHL overall or by subtype.Previo

186 Oral sensory signals drive dietary fat intake, but the neural mechanisms underlying

187 We sought to test the role of high dietary fat intake, diet-induced obesity, and associated

188 differences were attributable to changes in dietary fat intake, physical activity levels, or statin

189 cular disease (CVD) prevention than is total dietary fat intake.

190 coneogenesis that is elevated by obesity and dietary fat intake.

191 iometabolic diseases through optimization of dietary fat intake.

192 ariant and glucose tolerance is modulated by dietary fat intake.

193 t and vegetables, sodium intake, energy, and dietary fat intake.

194 NHL risk associated with total and specific dietary fat intake.We evaluated associations within the

195 fied by body mass index (BMI), exercise, and dietary fat intake].

196 se homeostasis; however, studies on habitual dietary fat intakes and gestational diabetes mellitus (G

197 rformed with semen variables as outcomes and dietary fat intakes as exposure variables, adjusted for

198 dium intakes with BP and of added sugars and dietary fat intakes with blood lipids.

199 fat diet group (P = 0.02), although the gene-dietary fat interaction became nonsignificant (P = 0.30)

200 we found statistically significant genotype-dietary fat interaction on the change in total abdominal

201 Genotype-dietary fat interaction was also examined.

202 wer risk.In a Mediterranean trial focused on dietary fat interventions, baseline intake of saturated

203 Proper storage of excessive dietary fat into subcutaneous adipose tissue (SAT) preve

204 However, entry of dietary fat into the circulation occurs at a reduced rat

205 The absorption of dietary fat involves the re-esterification of digested t

206 ing that an individual's capacity to oxidize dietary fat is a metabolic determinant of weight change.

207 ntake is normal in MGAT2-deficient mice, and dietary fat is absorbed fully.

208 sity and associated metabolic disorders when dietary fat is abundant.

209 anisms underlying oro-gustatory detection of dietary fat is critical for the prevention and treatment

210 important for fatty acid esterification when dietary fat is in excess.

211 nexposed F4 male descendants to obesity when dietary fat is increased.

212 ovascular disease events, and the quality of dietary fat is known to influence serum concentrations o

213 absorption and extraintestinal metabolism of dietary fat is less clear.

214 The absorption of dietary fat is of increasing concern given the rise of o

215 abolic challenges, such as exercise and high dietary fat, is necessary to promote skeletal muscle hea

216 erweight or obese and consume a diet high in dietary fat, it is critical to examine the consequences

217 Excessive intake of dietary fats leads to diminished brain dopaminergic func

218 ntestinal ultrastructure was not affected by dietary fat level or probiotic inclusion.

219 modified the oxidation of the 2 most common dietary fats, likely through a better trafficking and up

220 various equations suggested that changes in dietary fat made minimal contributions to the observed t

221 sitivity of fasting triglycerides and CRP to dietary fat manipulation in those with an APOE3/E4 genot

222 The response of plasma lipids to dietary fat manipulation is highly heterogeneous, with s

223 rmine the plasma long-chain PUFA response to dietary fat manipulation.

224 diture (REE) have suggested that the type of dietary fat may alter energy expenditure (EE).

225 hese findings reveal new mechanisms by which dietary fat may alter mesolimbic circuit function and re

226 ory and novelty-seeking behaviors induced by dietary fat may be mediated by enhanced nicotinic cholin

227 Dietary fats may affect blood lipid levels and the devel

228 al studies have suggested that the intake of dietary fat might be a contributing factor in the etiolo

229 iome alterations caused by overindulgence of dietary fat might increase susceptibility to food allerg

230 Moreover, health effects of dietary fats might be modified by additional factors, su

231 bolic complications responded differently to dietary fat modification, being more susceptible to a he

232 include vitamin D insufficiency, unhealthful dietary fat, obesity, increased hygiene, and the timing

233 Difference in dietary fat/oil (10 g/day), time spent engaged in modera

234 and focus particularly on behaviours such as dietary fat/oil intake, time spent on watching televisio

235 ntial mechanism for the extensive effects of dietary fat on health and disease.

236 ines response to the quantity and quality of dietary fat on MetS risk factors, which suggests that ta

237 c alterations in the quality and quantity of dietary fat on MetS risk factors.

238 12), or 1-h access to an optional source of dietary fat on Monday, Wednesday, and Friday (MWF; n = 1

239 t-induced obesity to investigate the role of dietary fat on myofibroblast differentiation in the mamm

240 This study evaluated the effect of dietary fat on prostate cancer development by using the

241 We studied the influence of the amounts of dietary fat on the effectiveness of carotene-rich plant

242 effect of substituting PO for other primary dietary fats on blood lipid-related markers of coronary

243 The effect of dietary fats on cardiometabolic diseases, including card

244 Dietary fat overconsumption leads to myocardial lipid ac

245 Dietary fat oxidation as a percentage of fat consumed wa

246 Dietary fat oxidation was determined from the percentage

247 expenditure (AEE) is a major determinant of dietary fat oxidation, which is a central component of f

248 This study explored 2 major dietary fats, palmitate and oleate, in supporting endoge

249 Our data do not support the idea that dietary fat per se promotes ectopic adiposity and cardio

250 The response to dietary fat plays a key role in metabolic health.

251 wild-type mice on food intake, body weight, dietary fat preference, and glucose tolerance.

252 w links between intestinal Cu metabolism and dietary fat processing.

253 Dietary fat promotes pathological insulin resistance thr

254 rs9364628, showed moderate interaction with dietary fat quality and a consistent direction of effect

255 Dietary fat quality and fat replacement are more importa

256 esults support dietary guidelines to improve dietary fat quality by replacing intake of SFAs with n-6

257 Dietary fat quality may influence skeletal muscle lipid

258 However, the impact of dietary fat quality on brain function, behavior, and sle

259 sible interaction between PARK2 variants and dietary fat quality on serum LDL-cholesterol concentrati

260 ify the variation in serum lipid response to dietary fat quality.

261 e of the biological and molecular effects of dietary fat quality.

262 ologic alterations that occur when improving dietary fat quality.

263 ruitment approach to determine the effect of dietary fat quantity and composition on both lipid and n

264 Dietary fat (r = 0.643, P = 0.004), carbohydrate (r = -0

265 We conclude that dietary fat reduction delays transition from mPIN to inv

266 age breast cancer tested the hypothesis that dietary fat reduction would increase the relapse-free su

267 DL cholesterol was not useful for predicting dietary fat response.

268 abolic vulnerability that largely depends on dietary fat restriction.

269 Finally, a moderate increase in total dietary fat resulted in a 2.7-fold reduction in eosinoph

270 tween quintiles of total fat and subtypes of dietary fat (saturated, monounsaturated, polyunsaturated

271 onoenoic and dienoic fatty acid component of dietary fat selectively initiates endocannabinoid mobili

272 At 6 months, dietary fat significantly modified genetic effects on ch

273 Ingestion of dietary fat stimulates production of the small-intestina

274 that spillover, a measure of inefficiency in dietary fat storage, is inversely associated with lower

275 iacin provides a model for acutely improving dietary fat storage, perhaps by suppressing lipolysis in

276 t source of FFA and reflects inefficiency in dietary fat storage.

277 with a severely impaired pathway for direct dietary fat storage.

278 objectives were to assess whether intakes of dietary fat, subtypes of fat, and fat from animal produc

279 Americans place greater emphasis on types of dietary fat than total amount of dietary fat and recomme

280 ese patients, prior to bypass, ingest excess dietary fat that can produce hyperphagic steatorrhea.

281 rats to identify fatty-acid constituents of dietary fat that might be responsible for triggering sma

282 ycerides (TGs) are the major transporters of dietary fats throughout the bloodstream.

283 e complement promotes the bioavailability of dietary fat to accelerate atherosclerosis.

284 l absorption can be modulated by structuring dietary fat to modulate postprandial lipemia and lipid b

285 nd those responsible for the contribution of dietary fats to colorectal cancer progression.

286 There was no significant association between dietary fat (total, saturated, monounsaturated, and poly

287 n apparently results in more partitioning of dietary fat toward energy dissipation rather than toward

288 A study was undertaken to relate dietary fat types to cognitive change in healthy communi

289 s studied in the absence and presence of two dietary fat types.

290 cells led to lacteal regression and impaired dietary fat uptake.

291 Until recently, dietary fat was considered to be tasteless, and its prim

292 es are dynamically modulated by the types of dietary fat we consume.

293 To isolate the effect of dietary fat, we generated high-fat diets with varying fa

294 We examined whether intakes of dietary fat were associated with UL incidence in a 5-yea

295 Responses to dietary fat were not associated with changes in polyprot

296 0 y of follow-up, neither total nor specific dietary fats were significantly associated with NHL risk

297 rred when PO was substituted for the primary dietary fats, whereas only favorable changes occurred wh

298 associated with either measure of BP nor was dietary fat with blood lipids.

299 This review explores what happens to dietary fat within the enterocyte.

300 n anorectic N-acylethanolamine produced from dietary fats within the intestinal lumen that can modula