ライフサイエンスコーパス: differentially methylated region

1 ial methylation spanning multiple CpG sites (differentially methylated regions).

2 cant loss in the DNA methylation of the Peg3 differentially methylated region.

3 We generated mice with deletion of the 1A differentially methylated region.

4 and/or tumors the 5'-CpG island of LOT1 is a differentially methylated region.

5 rmation among colocalized probes to identify differentially methylated regions.

6 ombines MeDIP-seq and MRE-seq data to detect differentially methylated regions.

7 1 and H3K9me3 binding were detected on their differentially methylated regions.

8 n primary and cancer cells revealed multiple differentially methylated regions.

9 We term these sequences gDMRs, for germline differentially methylated regions.

10 pGs associated with PMA, as well as multiple differentially methylated regions.

11 79 CpGs (false discovery rate < 0.05) and 36 differentially methylated regions.

12 We also identified differentially methylated regions.

13 2R, could be associated with the neighboring differentially methylated regions.

14 .59 x 10(-6)) and CD8(+) (P = 2.10 x 10(-8)) differentially methylated regions.

15 s cell carcinoma (OPSCC) samples to identify differentially methylated regions.

16 rdant for alcohol use disorder and validated differentially methylated regions.

17 and the epigenetically regulated silencer at differentially methylated region 1 (DMR1) of Igf2.

18 2/H19 imprinting control region (ICR), Igf2r differentially methylated region 2 (DMR2) and bacterial

19 eterm infants have altered 5mC at the linked differentially methylated region 2 (DMR2) of IGF2 and th

20 The differentially methylated region 2 of Igf2 was hypermeth

21 ling control group, we identified 195 unique differentially methylated regions: 5 in hypertrophic obs

22 r reporter assays, revealed that within this differentially methylated region, a single CpG dinucleot

23 In particular, statistical identification of differentially methylated regions across different condi

24 cing methylome profiling identified numerous differentially methylated regions across the genome in t

25 These data suggest that the 2-kb differentially methylated region acts as a key regulator

26 els across CpG islands and a large number of differentially methylated regions adjacent to genes whic

27 We identify aging-associated differentially methylated regions (aDMRs) in whole blood

28 These age-associated differentially methylated regions also show marked enric

29 infant sex-specific preeclampsia-associated differentially methylated regions among singletons.

30 Differentially methylated region analysis identified the

31 Differentially methylated region analysis, joint epigene

32 een promoter-proximal elements including the differentially methylated region and downstream elements

33 e, we report characterization of the WT1 ARR differentially methylated region and show that it contai

34 ile also introducing new methods for calling differentially methylated regions and detecting copy num

35 Additionally, four differentially methylated regions and one module were si

36 pression, respectively (P < 2.8 x 10(-6) for differentially methylated regions and P < 7.8 x 10(-10)

37 e genome-wide methylome analysis results for differentially methylated regions and their potential ef

38 methylation patterns across sex, hundreds of differentially methylated regions are detected.

39 Differentially methylated regions are hypomethylated and

40 ree DNA reveal many of the 51,259 identified differentially methylated regions are located in domains

41 es, which are mostly orthogonal to classical differentially methylated regions, are enriched at cell

42 offspring hippocampal DNA methylation showed differentially methylated regions as a result of both ME

43 Here, we characterize a differentially methylated region associated with the mou

44 d between-group analyses identified numerous differentially methylated regions associated with ASD.

45 omoter, and a decrease of DNA methylation in differentially-methylated regions associated with the Le

46 ng septic and nonseptic patients, 81% of the differentially methylated region-associated genes were d

47 onstrate that deletions of a small noncoding differentially methylated region at 16q24.1, including l

48 ly derived targeted deletion of the germline differentially methylated region at exon 1A abolishes ti

49 The results establish that the differentially methylated region at exon 1A contains an

50 A differentially methylated region at the Ascl1 promoter,

51 plied to any biological settings to identify differentially methylated regions at the genomic scale.

52 olution genome-wide profiling, we identified differentially methylated regions between control and Dn

53 se methods differ in their ability to detect differentially methylated regions between pairs of sampl

54 ength in circulating cell-free DNA, identify differentially methylated regions between sample groups,

55 ) display epigenomic reprogramming with many differentially-methylated regions, both hypermethylated

56 n start site and mapped a cell-type-specific differentially methylated region bracketing the Bcl11b p

57 Methylation of differentially methylated regions can be restored coinci

58 hylomes identified 101,466 cancer-associated differentially methylated regions (cDMRs).

59 shared methylated sites and four times fewer differentially methylated regions compared to samples fr

60 A total of 668 differentially methylated regions corresponding to 443 g

61 ination map based on 126 meiotically stable, differentially methylated regions covering 81.9% of the

62 led nearly three thousand cell-type specific differentially methylated regions (ctDMRs).

63 These differentially methylated regions did not occur at the l

64 wide association study (EWAS), we identified differentially methylated regions (DMPs): 14 were associ

65 Maternal deletion of the NESP55 differentially methylated region (DMR) (delNESP55/ASdel3

66 MethylCap-Seq revealed a differentially methylated region (DMR) adjacent to the d

67 transmission leads to methylation of the H19 differentially methylated region (DMR) and silencing of

68 ly derived targeted deletion of the germline differentially methylated region (DMR) associated with t

69 ated off-target coverage enables genome-wide differentially methylated region (DMR) calling for clust

70 marsupial genomes and the demonstration of a differentially methylated region (DMR) in the retrotrans

71 We have identified a 556 bp differentially methylated region (DMR) located approxima

72 Furthermore, loss of methylation at a differentially methylated region (DMR) of this locus, ex

73 and cohesins preferentially bind to the Gtl2 differentially methylated region (DMR) on the unmethylat

74 Genetic analyses demonstrate that the differentially methylated region (DMR) upstream of the H

75 escribed previously is hypermethylation of a differentially methylated region (DMR) upstream of the H

76 the H19 gene, and aberrant methylation of a differentially methylated region (DMR) upstream of the m

77 hylation pattern, the second CpG island is a differentially methylated region (DMR) with maternal met

78 ntly all CpGs within a CpG island (CGI) or a Differentially Methylated Region (DMR), avoiding 'one-at

79 gene 3 (Meg3) locus is regulated by the Meg3 differentially methylated region (DMR), but the mechanis

80 r allele-specific CpG methylation in the H19 differentially methylated region (DMR), Igf2 DMR0 or Igf

81 -associated hypermethylation at the upstream differentially methylated region (DMR), which also inclu

82 2 LOI correlates with hypomethylation at the differentially methylated region (DMR)-0.

83 eg3 is predicted to be regulated by the Peg3-differentially methylated region (DMR).

84 ifferentially methylated region [the exon 1A differentially methylated region (DMR)] that is methylat

85 Multiple differentially methylated regions (DMR) could be identif

86 We identified 3,506 cancer-specific differentially methylated regions (DMR) in human breast

87 examined allele-specific methylation of the differentially methylated regions (DMR) of IGF2 and H19

88 Differentially methylated regions (DMR) were identified

89 we have discovered two previously unreported differentially methylated regions (DMR): one in the prom

90 Using a differentially-methylated region (DMR) approach, we foun

91 on from human brain tissues, we identified a differentially methylated region, DMR-DLGAP2, associated

92 sters including virtually all known germline differentially methylated regions (DMRs) and 23 previous

93 ytes, and placenta, and identify 795 hap-ASM differentially methylated regions (DMRs) and 3,082 stron

94 A total of 853 significantly differentially methylated regions (DMRs) and 963 differe

95 We analyzed an additional 11 differentially methylated regions (DMRs) and found that,

96 fy predominately hypermethylated T2D-related differentially methylated regions (DMRs) and replicate t

97 thylated promoters in prostate tissues, 2481 differentially methylated regions (DMRs) are cancer-spec

98 Furthermore, many of the Gsk-3-dependent, differentially methylated regions (DMRs) are identical t

99 methylation in any context, but thousands of differentially methylated regions (DMRs) are identified

100 c scale, both cell-type- and cancer-specific differentially methylated regions (DMRs) are identified

101 Differentially methylated regions (DMRs) are stable epig

102 the aim of identifying previously unreported differentially methylated regions (DMRs) associated prim

103 We identified 1027 differentially methylated regions (DMRs) associated with

104 encing analysis of methylated DNA identified differentially methylated regions (DMRs) associated with

105 Cluster-based analyses revealed additional differentially methylated regions (DMRs) associated with

106 ially methylated CpG positions (DMPs) and 10 differentially methylated regions (DMRs) associated with

107 n the methylation status of specific CpGs in differentially methylated regions (DMRs) at affected but

108 e are still 5,000 to 20,000 context-specific differentially methylated regions (DMRs) between any two

109 d cytosines (mCs) in a sample, and to detect differentially methylated regions (DMRs) between paired

110 We show here that single differentially methylated regions (DMRs) correlate with

111 A total of 400 differentially methylated regions (DMRs) discriminated p

112 ependent and maps only to imprinting control differentially methylated regions (DMRs) established in

113 n smoothing approach (called ABBA) to detect differentially methylated regions (DMRs) from whole-geno

114 Of 811 differentially methylated regions (DMRs) identified in A

115 we found to significantly overlap with known differentially methylated regions (DMRs) in colon tumors

116 TF family; they are also enriched for common differentially methylated regions (DMRs) in CRC.

117 cape in human pancreatic islets, to identify differentially methylated regions (DMRs) in diabetic isl

118 Differentially methylated regions (DMRs) in each methyla

119 ult from aberrant establishment of imprinted differentially methylated regions (DMRs) in gametes or t

120 compared to healthy controls and identified differentially methylated regions (DMRs) in HLA-DRB1 and

121 sulfite sequencing we identified hundreds of differentially methylated regions (DMRs) in humans compa

122 ts have not been identified, and the role of differentially methylated regions (DMRs) in Igf2 has not

123 was reprogrammed after fertilization in two differentially methylated regions (DMRs) in Igf2, and wa

124 4K12, H2AK5, H2BK12, H2BK16 and H2BK46 at 11 differentially methylated regions (DMRs) in reciprocal m

125 t Cytosine-phosphate-Guanine (CpG) sites and differentially methylated regions (DMRs) in relation to

126 developed for identifying disease-associated differentially methylated regions (DMRs) in the epigenom

127 significant changes in DNA methylation at 12 differentially methylated regions (DMRs) in the genes: A

128 The differentially methylated regions (DMRs) in the reprogra

129 ctive X-chromosome and in tumors, as well as differentially methylated regions (DMRs) in the vicinity

130 gene promoters, 4% of which reside in known Differentially Methylated Regions (DMRs) including repro

131 So it is more desirable to identify differentially methylated regions (DMRs) instead of DMPs

132 The detection of differentially methylated regions (DMRs) is a necessary

133 nism in gene regulation and the detection of differentially methylated regions (DMRs) is enthralling

134 The gene contains three differentially methylated regions (DMRs) located upstrea

135 o parthenogenetic mouse embryos, to identify differentially methylated regions (DMRs) methylated spec

136 ration of normal DNA methylation patterns in differentially methylated regions (DMRs) of affected loc

137 onders from nonresponders, we identified 167 differentially methylated regions (DMRs) of DNA at basel

138 blastocysts display hypermethylation in the differentially methylated regions (DMRs) of Peg3 and Gna

139 DNA methylation profiling reveals important differentially methylated regions (DMRs) of the genome t

140 conserved sequences between human and mouse differentially methylated regions (DMRs) of the IGF2 gen

141 In addition, differentially methylated regions (DMRs) often contain s

142 wide studies discovered that tissue-specific differentially methylated regions (DMRs) often overlap t

143 Eleven age-associated differentially methylated regions (DMRs) passed Bonferro

144 e to cigarette smoking on methylation at two differentially methylated regions (DMRs) regulating Insu

145 However, identifying differentially methylated regions (DMRs) remains a chall

146 Identification of differentially methylated regions (DMRs) revealed that D

147 is pipeline, we identified 3751 CpGs and 119 differentially methylated regions (DMRs) significantly a

148 of cell types within a sample by leveraging differentially methylated regions (DMRs) specific to cel

149 s show abnormal distributions of overlapping differentially methylated regions (DMRs) such as hyperme

150 Nevertheless, we identify more than 16,000 differentially methylated regions (DMRs) that are distri

151 , this pattern of expression is regulated by differentially methylated regions (DMRs) that are establ

152 early childhood lead exposure can alter the differentially methylated regions (DMRs) that control th

153 usands of genome-wide significant (q < 0.05) differentially methylated regions (DMRs) that distinguis

154 ted, here, we present a new method to detect differentially methylated regions (DMRs) that uses combi

155 From these CpGs, RADMeth identified 557 differentially methylated regions (DMRs) that were overr

156 and identified four genome-wide significant differentially methylated regions (DMRs) using a bump hu

157 DNA methylation at 12 differentially methylated regions (DMRs) was analyzed in

158 ccordingly, 32,990 early-postpartum-specific differentially methylated regions (DMRs) were found in g

159 escence in dml3 compared with WT, and 20 556 differentially methylated regions (DMRs) were identified

160 Differentially methylated regions (DMRs) were identified

161 rinting control regions (ICRs) and secondary differentially methylated regions (DMRs) were identified

162 d at a false discovery rate (FDR) < 0.05 and differentially methylated regions (DMRs) were identified

163 A total of 4,689 differentially methylated regions (DMRs) were identified

164 n transcription factor binding and to reveal differentially methylated regions (DMRs) with context-sp

165 identified 40, 66 and 2136 genes containing differentially methylated regions (DMRs) with negative c

166 sue and cell type specific, the detection of differentially methylated regions (DMRs) with small effe

167 significance is established at the level of differentially methylated regions (DMRs), and bootstrapp

168 single methylation polymorphisms and 2485 CG differentially methylated regions (DMRs), both of which

169 Three differentially methylated regions (DMRs), each with diff

170 YY1 binding sites are located within several differentially methylated regions (DMRs), including Xist

171 Notably, we identify a cohort of differentially methylated regions (DMRs), most of which

172 res are limited to imprinted genes and their differentially methylated regions (DMRs), whereas broad

173 The Dlk1-Gtl2 locus carries three differentially methylated regions (DMRs), which are meth

174 erentially methylated positions (DMPs) and 5 differentially methylated regions (DMRs), which we study

175 ngly, the oocyte contributes a unique set of differentially methylated regions (DMRs)--including many

176 to all other regions, and showed over 16 000 differentially methylated regions (DMRs).

177 gical contexts, with the goal of identifying differentially methylated regions (DMRs).

178 Zea mays) inbred lines were used to discover differentially methylated regions (DMRs).

179 methylation at the Igf2 P2 promoter and Igf2 differentially methylated regions (DMRs).

180 rinted genes based on their association with differentially methylated regions (DMRs).

181 but exhibited large-scale redistribution of differentially methylated regions (DMRs).

182 tion protocol (n = 24) were used to identify differentially methylated regions (DMRs).

183 phosphate-guanine (CpG) sites and another on differentially methylated regions (DMRs).

184 recovered using an existing method based on differentially methylated regions (DMRs).

185 ost imprinted loci marked by the presence of differentially methylated regions (DMRs).

186 We identified 2,130 differentially methylated regions (DMRs; <5% false disco

187 novel computational pipeline that identifies differentially methylated regions efficiently.

188 y differentially expressed genes (DEGs) with differentially methylated regions encoding transcription

189 Differentially methylated positions and differentially methylated regions encompassed genes invo

190 der, we now report deletions that remove the differentially methylated region encompassing exon NESP5

191 y note to genome-wide searches on the use of differentially methylated regions for the identification

192 the computational approaches for identifying differentially methylated regions from high-throughput b

193 cessing, quality assessment and detection of differentially methylated regions from the kilobase to t

194 asses of genes associated with these gametic differentially methylated regions (gDMRs), namely those

195 Methylation at several imprinted differentially methylated regions (GRB10 ICR, H19 ICR, K

196 dynamic, and highly ordered, suggesting that differentially methylated regions have unique properties

197 etected are found highly consistent with the differentially methylated regions identified by using pu

198 Differentially methylated regions identified when compar

199 At least one cis-element, the intergenic differentially methylated region (IG-DMR) is required fo

200 An intergenic differentially methylated region (IG-DMR) located 13 kb

201 we identified an intergenic germline-derived differentially methylated region (IG-DMR) that is a cand

202 ouse brain DNA methylation, we found a novel differentially methylated region in a CpG island located

203 variation in DNA methylation at the VTRNA2-1 differentially methylated region in healthy Caucasian an

204 We identified a differentially methylated region in the ankyrin 1 (ANK1)

205 We identified a differentially methylated region in the promoter of the

206 We validated 11 of the differentially methylated regions in an independent set

207 A core set of differentially methylated regions in APL was identified.

208 ylation analysis of the FCGRT locus revealed differentially methylated regions in DNA from liver and

209 ught stress, there were negligible conserved differentially methylated regions in drought-exposed lin

210 Results show that a network of differentially methylated regions in glucocorticoid sign

211 Differentially methylated regions in Igf2 and H19 contai

212 basis for the recognition and methylation of differentially methylated regions in imprinted genes, in

213 Differentially methylated regions in N-ERD macrophages i

214 k of genomic imprinting and parent-of-origin differentially methylated regions in Nasonia, together w

215 have searched for parent-of-origin dependent differentially methylated regions in order to identify n

216 egrative epigenomic approach revealed 10,504 differentially methylated regions in regulatory elements

217 methylation analysis identified a number of differentially methylated regions in TET2-deficient vers

218 formation capture technique to show that the differentially methylated regions in the imprinted genes

219 approach, we were able to identify specific differentially methylated regions in the parental genome

220 We detected 62 678 differentially methylated regions in the studied HF coho

221 apped to 23 chromosomal regions, and 12 were differentially methylated regions in uniparental tissues

222 orders, our findings suggest that the Nesp55 differentially methylated region is an additional princi

223 The imprinted Kcnq1 domain contains a differentially methylated region (KvDMR) in intron 11 of

224 nal allele-specific methylation (LOM) of the differentially methylated region KvDMR1.

225 seq is enriched among ASM loci, but most ASM differentially methylated regions lack such annotations,

226 ndem array of YY1 binding sites of Peg3-DMR (differentially methylated region) led us to identify thr

227 SA) hormone revealed numerous stress-induced differentially methylated regions, many of which were in

228 A total of 21 differentially methylated regions mapping to the 10-gene

229 cruitment to the maternally expressed gene 3 differentially methylated region (MEG3-DMR), which acts

230 binations further showed that these parental differentially methylated regions most likely mediate th

231 ating phenotype ensues, with 79% of the 2966 differentially methylated regions observed involving dem

232 served for the frequency of CpG sites in the differentially methylated regions of 12 maternally impri

233 tting of the EGC DNA was used to analyze the differentially methylated regions of Igf2 and H19.

234 he differential DNA methylation found on the differentially methylated regions of imprinted genes, an

235 ited abnormal patterns of methylation at the differentially methylated regions of the IGF2/H19 or IGF

236 l is a stressor, we focused our attention on differentially methylated regions of the NR3C1 gene and

237 H2A1 deposition levels at the ICRs and other differentially methylated regions of these domains are a

238 by bringing repressive histone marks on the differentially methylated regions of these three direct

239 the data pinpoint 15,112 high-confidence ASM differentially methylated regions, of which 1838 contain

240 We identify 19 differentially methylated regions on chromosome 6 harbor

241 genes with significant methylation changes, differentially methylated regions or differentially meth

242 Heritable and novel nonparental differentially methylated regions overlapping with genes

243 tion occurs predominantly in density-defined differentially methylated regions overlooks behavioral f

244 eristics of prenatal malnutrition-associated differentially methylated regions (P-DMRs) is lacking in

245 vation that a 45-bp sequence (DMR45) in this differentially methylated region positively influenced p

246 iPSCs share megabase-scale differentially methylated regions proximal to centromere

247 We identified hundreds of differentially methylated regions proximal to genes invo

248 For several of these 'differentially methylated regions', recent studies estab

249 Control of expression is complex, with three differentially methylated regions regulating germline, p

250 accompanied by changes in DNA methylation of differentially methylated regions related to these loci.

251 dicated that EC-enriched gene promoters with differentially methylated regions replicate early in S-p

252 We identified 52,095 differentially methylated regions (representing 1% of th

253 modifications in somatic tissue, and a sperm differentially methylated region (sDMR; sperm not equal

254 m-derived dermal fibroblasts, to identify SE differentially methylated regions (SE-DMRs).

255 The differentially methylated regions show enrichment for bi

256 DNA methylomes, 95.7 % of the age-associated differentially methylated regions showed the same direct

257 The top psychosis-associated, differentially methylated region, significantly hypometh

258 ntially binds to the methylated paternal H19 differentially methylated region, suggesting a mechanism

259 In protein-coding genes, tissue-specific differentially methylated regions (T-DMRs) were preferen

260 dentifying 223 new candidate tissue-specific differentially methylated regions (T-DMRs).

261 rate of linkage disequilibrium decay amongst differentially methylated regions targeted by RNA-direct

262 rehensive genome-wide set of tissue-specific differentially methylated regions (tDMRs) that may play

263 Tissue specific differentially methylated regions (TDMRs) were identifie

264 the results presented here, tissue-specific differentially methylated regions (TDMs) were first iden

265 dentified a novel parent-of-origin dependent differentially methylated region that has no apparent as

266 CpG sites at the Ido1 promoter constitute a differentially methylated region that is highly methylat

267 OPSCCs and identified a specific pattern of differentially methylated regions that critically depend

268 Neonatal immune cells harbored 589 differentially methylated regions that distinguished IIS

269 ns, as well as of six chimpanzees, to detect differentially methylated regions that likely emerged in

270 ingle differentially methylated CpG sites or differentially methylated regions that map to genes.

271 e and unique sequences, the latter including differentially methylated regions that regulate expressi

272 nalysis demonstrated a significant number of differentially methylated regions that were annotated ac

273 s in a human genome and identify hundreds of differentially methylated regions that were previously u

274 oter is unmethylated, but is downstream of a differentially methylated region [the exon 1A differenti

275 An intergenic, parental-origin-specific differentially methylated region, the IG-DMR, which is u

276 lignment with ENCODE data, we also found the differentially methylated regions to be enriched with CC

277 undergoing EMT and translated the identified differentially methylated regions to human breast cancer

278 ing maternal-allele-specific deletion of the differentially methylated region, to maintain hematopoie

279 Although differentially methylated regions, transcript number of

280 icant over-representation of tissue-specific differentially methylated regions (TS-DMRs) observed at

281 overage, we identify 302,864 tissue-specific differentially methylated regions (tsDMRs) and estimate

282 A differentially methylated region upstream of H19 (H19-DM

283 validation, the authors characterized these differentially methylated regions using personality trai

284 ndependent validation of selected cord blood differentially methylated regions, using bisulfite ampli

285 ode within the network of asthma-associated, differentially methylated regions, was selectively incre

286 Among other differentially methylated regions, we identified a 1 Kb

287 Differentially methylated regions were associated with c

288 Among asthmatic patients, 11 differentially methylated regions were associated with h

289 ies using similar methodology, many of these differentially methylated regions were associated with l

290 About 5000 differentially methylated regions were consistently dete

291 Importantly, differentially methylated regions were enriched at cis-e

292 methylation, in silico analysis showed that differentially methylated regions were enriched in trans

293 l line, NT2, we previously demonstrated that differentially methylated regions were located in intron

294 s and 24 matched controls were conducted and differentially methylated regions were validated.

295 control regions (ICRs) as well as some novel differentially methylated regions which, due to their pr

296 formance and enables identification of novel differentially methylated regions, which we independentl

297 In response to SA, transposon-associated differentially methylated regions, which were accompanie

298 in each of 3 diagnostic categories), and 54 differentially methylated regions with P < .01 were iden

299 nd/or cohesin bind to a majority but not all differentially methylated regions, with preferential bin

300 d 19-82 years, we identify 71 age-associated differentially methylated regions within the linkage dis