ライフサイエンスコーパス: differentiation

1 elial activation, ILC2 expansion, and T(H) 2 differentiation.

2 Ac at Threonine 717 as a driver of astrocyte differentiation.

3 lar subtype mutations and lineage-restricted differentiation.

4 al repair, and implicate ST2 in myeloid cell differentiation.

5 duced apoptosis, cell cycle arrest, and cell differentiation.

6 ll differentiation at the expense of NK cell differentiation.

7 methylation that governs early steps of ESC differentiation.

8 commitment of adjacent myoblasts to terminal differentiation.

9 l resolution through in vivo mouse erythroid differentiation.

10 and IL-21 dichotomously shape CD8(+) T cell differentiation.

11 activation and enforced alphabeta T lineage differentiation.

12 e interaction enrichment of genes related to differentiation.

13 erase (Pol) II and regulates cell growth and differentiation.

14 ic genes in a manner correlated with myeloid differentiation.

15 omote their self-renewal, proliferation, and differentiation.

16 ; and more recently, transcriptional profile differentiation.

17 erturbations disrupt morphogenesis and histo-differentiation.

18 dy changes driving and accompanying neuronal differentiation.

19 ed regulation of progenitor self-renewal and differentiation.

20 ntinuously observe changes over many days of differentiation.

21 the global level, their paternal origins and differentiation.

22 , CSR, somatic hypermutation and plasma cell differentiation.

23 gene sets involved in neuron development and differentiation.

24 nces critical genes involved in keratinocyte differentiation.

25 nexpectedly, we found that VHL promotes Th17 differentiation.

26 also the near-IR region can be used for good differentiation.

27 tially decreased among-region and among-site differentiation.

28 and IL-6, cytokines known to drive Th17 cell differentiation.

29 synthetic expression is sufficient to drive differentiation.

30 in mammalian genomes during development and differentiation.

31 em and progenitor cells and inhibiting their differentiation.

32 tly to mediate mRNA degradation and cellular differentiation.

33 the transcriptional circuitry governing MBC differentiation.

34 egulated gene expression and delayed ES cell differentiation.

35 ses linked to loss of vascular smooth muscle differentiation.

36 S content marking proliferative activity and differentiation.

37 also target oropharyngeal and cranial nerve differentiation.

38 erent characteristic level of cancer cell de-differentiation.

39 teins known to play an important role in sex differentiation.

40 ls navigate their growth, proliferation, and differentiation.

41 ors of proliferative quiescence and terminal differentiation.

42 ape of regulatory mechanisms underlying cell differentiation.

43 y increased GM-CSF production and T(H)2 cell differentiation.

44 cal properties of An-BA to improve glycoform differentiation.

45 cardin, which prevented airway smooth muscle differentiation.

46 ssible within pre-existing TADs during early differentiation.

47 or MSC attachment and enhancing chondrogenic differentiation.

48 cell states, such as fate decision states in differentiation.

49 ntions can guide them through their neuronal differentiation.

50 regulation of plant growth, development and differentiation.

51 ated with repression of terminal chondrocyte differentiation.

52 cated Notch signaling in inducing enterocyte differentiation.

53 ic reader involved in cell proliferation and differentiation.

54 lows for molecular identification and isomer differentiation.

55 ng the maintenance of Isl1 expression during differentiation.

56 ient mouse embryos display premature cardiac differentiation.

57 intracellular signalling cascades promoting differentiation.

58 ngiogenic factors production and endothelial differentiation.

59 type-specific machinery to control cellular differentiation.

60 ng in identifying novel regulators of T cell differentiation.

61 indered by promotion of terminal plasmacytic differentiation.

62 itro and in vivo, thereby inducing stem cell differentiation.

63 such as neural proliferation, migration, and differentiation.

64 cancer pathogenesis, we found the cluster of differentiation 177 (CD177), a known neutrophil antigen,

65 a BsAb with two target antigens, cluster of differentiation 3 (CD3) and B-cell maturation antigen (B

66 coupled receptor 120 (GPR120) and cluster of differentiation 36 (CD36), in a spatiotemporal manner in

67 HIF-1alpha positively regulates Th17 differentiation, a complex process in which quiescent na

68 e genetic diversity but display high genetic differentiation, a potential consequence of both regions

69 e of new and more horizontal forms of social differentiation across genders.

70 ave identified genomic "islands" of elevated differentiation against a background of relative homogen

71 an cytomegalovirus (HCMV) latency, and their differentiation along the myeloid lineage triggers cellu

72 that influence expression dynamically during differentiation and across cellular contexts.

73 g contribute to fibroblast and myofibroblast differentiation and activation, which further perpetuate

74 in the bone marrow and involved in lymphoid differentiation and activation.

75 We hypothesized that ML differentiation and CAR engineering would result in comp

76 onsequently, EPKs play crucial roles in cell differentiation and cell-cycle progression, and kinase d

77 eased proliferation and altered jaw skeletal differentiation and cleft palate.

78 gate the effects of soluble Si on osteogenic differentiation and connexin 43 (CX43) gap junction comm

79 ls, acting as a barrier to prevent premature differentiation and controlling epigenetic integrity.

80 ers show an enrichment for genes involved in differentiation and development.

81 n, which is essential for T cell activation, differentiation and effector functions.

82 that reflect an altered course of epidermal differentiation and enhanced inflammatory responses.

83 omplex components, SOX6 suppresses epidermal differentiation and epigenetically silences critical gen

84 display a prominent feature of Th2 and Th17 differentiation and exert high efficacy and potency to h

85 Allopolyploidy promotes differentiation and facilitates adaptation to new enviro

86 o1 in XX humans and mice leads to testicular differentiation and female-to-male sex reversal in a man

87 Endothelial differentiation and function were enhanced by blocking T

88 role for NR4A3 in programming CD8(+) T cell differentiation and function.

89 during induced pluripotent stem cell (iPSC) differentiation and in tumors versus normal tissues.

90 ther revealed that ASD genes activate neural differentiation and inhibit cell cycle during the transi

91 e underlying mechanisms are ill-defined, the differentiation and maturation of crossover-specific rec

92 poxia and sovateltide also showed higher NPC differentiation and maturation.

93 enable the control of neural stem cell (NSC) differentiation and neurite outgrowth.

94 we report that anxiolytic FGIN-1-27 inhibits differentiation and pathogenicity of Th17 cells in vitro

95 It is important for hematopoietic differentiation and plays a central role in malignant di

96 Cell differentiation and proliferation require Hedgehog (HH)

97 ranslation of lncRNAs during hESC pancreatic differentiation and provides a blueprint for dissection

98 with gas-phase ion chemistry to achieve both differentiation and quantification of the diastereomeric

99 quired to maintain the balance proliferation differentiation and suggest that is part of the squamous

100 gands may contribute to vestibular hair cell differentiation and supports a developmental model in wh

101 Zinc and copper are involved in neuronal differentiation and synaptic plasticity but the molecula

102 iciency influences osteoblast and osteoclast differentiation and that it is associated with thinner c

103 r LDH in modulating cytokine-mediated T cell differentiation and underscore the therapeutic potential

104 tor, participates in cellular proliferation, differentiation, and death.

105 monocyte translocation into the lung, Mo-AM differentiation, and development of pulmonary fibrosis.

106 in organization is critical for cell growth, differentiation, and disease development, however, its f

107 les in regulating the development, survival, differentiation, and function of immune cells.

108 cells results in enhanced T-cell activation, differentiation, and function, which translates in vivo

109 cluding some with roles in proliferation and differentiation, and in IGF and TGFbeta signalling pathw

110 y regulation is essential for cell survival, differentiation, and migration.

111 DNAme shapes the topography of hematopoietic differentiation, and support a model in which genome-wid

112 emokines and cytokines for the localization, differentiation, and survival of Trm and Trm precursors.

113 at fertilization, embryonic stem cell (ESC) differentiation, and the continuous maintenance of cell

114 em cells (hNSCs) show high viability, neural differentiation, and the formation of functional, stimul

115 T cell expansion and differentiation are critically dependent on the transcri

116 onment is pivotal for pancreas formation and differentiation as well as adult organ homeostasis.

117 , particularly in cellular proliferation and differentiation, as well as in systemic versus localized

118 P-70(-/-) mice resulted in a rapid thymocyte differentiation associated with the development of a thy

119 ) NKDIs promoted non-NK innate lymphoid cell differentiation at the expense of NK cell differentiatio

120 complicates teasing apart at what stages of differentiation autophagy plays a critical role.

121 Here, we show that this differentiation becomes possible by adding the local env

122 A rapid and reliable method for the differentiation between active and inactive bacteria at

123 The inter-differentiation between cell states promotes cancer cell

124 as successfully tested on two cases, namely, differentiation between cultivars and detection of adult

125 CBG in hemp, as well as enable confirmatory differentiation between hemp, cannabis, and CBD-rich hem

126 single T. cruzi mitochondrion are linked to differentiation by a yet-unknown signaling mechanism.

127 and analyzed ISC number, proliferation, and differentiation by flow cytometry, immunofluorescence, a

128 uggesting that LSD1 regulates endocrine cell differentiation by limiting the duration of RA signallin

129 that GPRC5B regulates vascular SMC tone and differentiation by negatively regulating IP signaling.

130 The transcription factor GRHL3 regulates IFE differentiation by transcriptionally activating terminal

131 Using WBM and matched cluster of differentiation (CD)138-selected tumor gene expression t

132 and involved in regulation of organogenesis, differentiation, cell migration and proliferation.

133 ia-related markers and enhanced chondrogenic differentiation compared to BMSCs cultured on the assemb

134 monstrated reduced proliferation and delayed differentiation compared with those from WT muscles.

135 stem cells respond to dynamic variations in differentiation cues is not well characterized.

136 Conversely, the monolayer differentiation culture derived a mixture of Tbr1 and Ct

137 mmunolabelled using makers for odontoblastic differentiation, cytoskeleton components and growth fact

138 the molecular basis of sinonasal mucociliary differentiation, demonstrating that transcriptome relate

139 Polarization is a crucial component in cell differentiation, development, and motility, but its deta

140 terized a regulatory mechanism of endodermal differentiation driven by the microbiota with profound e

141 e features, including cellular asymmetry and differentiation during the cell cycle.

142 ted from both techniques reproduced expected differentiation dynamics.

143 ession of genes associated with keratinocyte differentiation (e.g., KRT1, GRHL2, SPRR4).

144 ify molecular markers that are predictive of differentiation efficiency of individual lines, and util

145 ineate gene expression profiles spanning key differentiation events in human thymopoiesis and provide

146 o is no exception, with the guided series of differentiation events producing heterogeneous cell popu

147 )-induced mouse embryonic stem cells (mESCs) differentiation experiment.

148 generation-related protein (NREP) and growth differentiation factor 15 (GDF15).

149 wnstream of GDF6, which codes for growth and differentiation factor 6.

150 in complex cell types with multiple possible differentiation fates.

151 D38 expression (P = 4.1e-5), and plasmacytic differentiation features (P = .008).

152 Significant down-regulation of terminal differentiation (FLG and FLG2), lipid synthesis/metaboli

153 X5, in individual cells during cardiomyocyte differentiation from human induced pluripotent stem cell

154 Published studies on in vitro RGC differentiation from stem cells utilized classical RGC s

155 mediators, its prosurvival versus activation/differentiation functions, and when it is relevant in pa

156 Moreover, a quantitative index called Differentiation Genes' Interaction Enrichment (DGIE) is

157 s the expression of region-specific neuronal differentiation genes, thereby controlling the timing of

158 ion by transcriptionally activating terminal differentiation genes.

159 ndent upon epigenetic regulation of key VSMC differentiation genes; notably, Kruppel-like factor 4 wa

160 Histopathologic subtype, differentiation grade, lymphovascular invasion, perineur

161 inding that PTPN14 binding by HPV E7 impairs differentiation has significant implications for HPV-med

162 Fbeta signaling and suppresses myofibroblast differentiation, however practical strategies to raise t

163 s roles in cell survival, proliferation, and differentiation; however, its function in chronic liver

164 strated that Msi1 overexpression affects IEC differentiation in a region-specific manner, with ileum

165 hick crust, which explains why magmatism and differentiation in continental arcs, like the Andes, rea

166 nscription factors controlling cell fate and differentiation in many developmental and adult processe

167 RSL genes which positively regulate cell differentiation in roots were either exclusively or pref

168 f c-di-AMP is critical for normal growth and differentiation in Streptomyces, connecting ionic stress

169 esses tumor growth and promotes keratinocyte differentiation in the 7,12-dimethylbenz[a]anthracene/12

170 We found excess differentiation in the CO(2) vent population for genes c

171 ed that TSLP can directly promote T(H)2-cell differentiation in the lung, independent of the draining

172 ments indicated a precocious oligodendrocyte differentiation in the mPFC at P15, leading to a depleti

173 Microbe-stimulated monocytes drive Th17 differentiation in vitro and induce cholangiocytes to pr

174 ether, this work sheds light on human airway differentiation in vitro and provides a single-cell atla

175 the expression of genes involved in early KC differentiation, including keratin 1, keratin 10, and DS

176 study, we demonstrated that 3T3L1 adipocytes differentiation increased ROS and protein S-glutathionyl

177 hat are increasingly enriched at DARs during differentiation, indicating regulatory networks that lik

178 ogen-specific immune responses through their differentiation into a number of subsets, including T(H)

179 acrophages to bone matrix and triggers their differentiation into osteoclasts.

180 ESR cells are pluripotent and capable of differentiation into primordial germ cell-like cells.

181 of Ftz-f1 expression prevents follicle cell differentiation into the final maturation stage, which l

182 to respond to FGFR signaling, preventing its differentiation into WG.

183 on, which in turn release FGF to induce SGs' differentiation into WG.

184 progenitor cell (HSPC) formation and lineage differentiation involve gene expression programs orchest

185 onstitutively unmethylated throughout T cell differentiation, irrespective of their activation status

186 ic stem cells (hESCs) irreversibly commit to differentiation is a fundamental yet unanswered question

187 s, our results confirm that ecological niche differentiation is an important component of polyploid s

188 Neuroendocrine differentiation is associated with treatment failure and

189 single cell RNA-seq to show that murine IFE differentiation is best described as a single step gradu

190 indings suggest that this novel glia-to-glia differentiation is both dependent on early lineage decis

191 This differentiation is complex and costly.

192 Sexual differentiation is controlled by diverse master regulato

193 Imaging differentiation is important for management and isolatio

194 onent of polyploid speciation and that niche differentiation is often significantly faster in polyplo

195 CD8 T cell differentiation is orchestrated by dynamic metabolic cha

196 ved in individuals with CHARGE, and neuronal differentiation is reduced in CHARGE patient-derived iPS

197 3 (AnxA3), a negative regulator of adipocyte differentiation, is down-regulated in RCC and shows a di

198 ong with reduced expression of smooth muscle differentiation markers in the carotids.

199 s EBV-infected B cells expressed plasma cell differentiation markers.

200 to a stronger increase in level of epidermal differentiation markers.

201 gonadal soma, suggesting that somatic sexual differentiation may be affected by external conditions.

202 ts into cellular proliferation, development, differentiation, migration, and treatment efficacy.

203 ation process, referred to as neuroendocrine differentiation (NED).

204 In higher plants, germline differentiation occurs during a relatively short period

205 However, a role for CBFA2T3 in myeloid differentiation of AML has not been reported.

206 Affinity maturation and terminal differentiation of B-cells via the germinal center react

207 ty Acid Oxidation (FAO) is essential for the differentiation of blood cell progenitors.

208 The differentiation of BMSCs was also improved, and the expr

209 s controlling tissue-specific adaptation and differentiation of cDCs are currently poorly understood.

210 The developmental cues controlling the differentiation of committed progenitors into these cell

211 estimate the probability of self-renewal or differentiation of cortical progenitor behaviors in vivo

212 ia function is significantly impaired during differentiation of CRSwNP epithelium due to an altered e

213 ut the asynchronous and unique trajectory of differentiation of each myoblast along the myogenic line

214 tream target KCTD1 is essential for terminal differentiation of early stage DCTs into mature DCTs, an

215 KDM6A is important for differentiation of embryonic stem cells and development

216 ant stabilize TP53 and impair the growth and differentiation of erythroid cells.

217 ing the molecular mechanisms that govern the differentiation of high-affinity germinal center (GC) B

218 aling is sufficient to promote mesendodermal differentiation of hPS cells.

219 me-wide analysis during in vitro mucociliary differentiation of human adult BSCs from CRSwNP, compare

220 Here, we investigated whether squamous trans-differentiation of human and mouse pancreatic cancer cel

221 y to show that pembrolizumab interferes with differentiation of human FOXP3(+) iTregs and to disclose

222 Here, we report the directed differentiation of human iPSCs into airway basal cells (

223 racterized the epigenome during the in vitro differentiation of human mesenchymal stem cells (hMSCs)

224 ose iAs increased self-renewal and decreased differentiation of human PrSPCs by activating the p62-NR

225 single-cell analysis and, consequently, for differentiation of indolent from aggressive phenotypes.

226 nd single-shot DWI for lesion visibility and differentiation of malignant and benign lesions within t

227 s modulated by their cofactors to refine the differentiation of neuronal subtypes.SIGNIFICANCE STATEM

228 e first 2 postnatal weeks caused a premature differentiation of oligodendrocytes similar to the MS pu

229 he regulation of adipokine secretion and the differentiation of osteoblasts and osteoclasts.

230 ated with prolactin (PRL) they increased the differentiation of other CD34(+) cell populations into t

231 cytocompatible substrates for attachment and differentiation of PC-12 neural progenitor cells.

232 n of WG differentiation with the progressive differentiation of photoreceptor neurons.

233 s a key evolutionary transition allowing for differentiation of physiological functions across a cell

234 urbed UPR in myeloid precursors and in vitro differentiation of primary CD34(+) cells revealing upreg

235 Hnf4a promotes the differentiation of PT progenitors into mature PT cells b

236 s in the bone marrow, and also regulates the differentiation of resident mesenchymal progenitor cells

237 ly expressed in cortical progenitors, drives differentiation of RGs into apical intermediate progenit

238 The addition of 0.6 equiv of ABTE allows the differentiation of several spiroglycol proton signals.

239 healing favours chondrogenic over osteogenic differentiation of skeletal progenitor cells.

240 ransduction pathways prevented myofibroblast differentiation of SKPs and expression of Ccn2.

241 riments allow for a rapid identification and differentiation of surface hydroxyl groups and (sub-)sur

242 es revealed a unique spectrum of memory-type differentiation of T-PLL with predominant central-memory

243 as a regulator of PKCzeta that controls the differentiation of Th2 cells important for AD pathogenes

244 with BC axonal differentiation, presynaptic differentiation of the AII ACs is not dependent on cues

245 Effective differentiation of the formation of HNO from complex 1 w

246 is study demonstrates de novo neuroendocrine differentiation of the human prostate luminal epithelial

247 The differentiation of the medulla is a cell-autonomous proc

248 During differentiation of the monolayers, the EC cell lineage w

249 cells from the PDL and gingiva, multilineage differentiation of those cells, and comparison of period

250 ther, our data provide new insights into the differentiation of transposons and their role in the asy

251 t of aberrant MBs prone to avoid plasmacytic differentiation on recall and undergo systemic dissemina

252 ature DCTs, and impairment of their terminal differentiation owing to lack of KCTD1 leads to a severe

253 ion of TGFbeta signaling and upregulation of differentiation pathways such as PDGFR signaling.

254 reprogramming associated with hematopoietic differentiation poses a major threat to genome stability

255 ng that although synchronized with BC axonal differentiation, presynaptic differentiation of the AII

256 s transient HSC-like population decreased as differentiation proceeded, and was completely missing in

257 biraterone and arises via a reversible trans-differentiation process, referred to as neuroendocrine d

258 ose that the origin and optimisation of this differentiation program represents repurposing of a gene

259 e histone modification H3K27me3 and activate differentiation programmes.

260 these data reveal the existence of parallel differentiation programs in the human CD8(+) memory T ce

261 itiated signaling as key element of the VSMC differentiation programs that can be targeted to modulat

262 human pluripotent stem cell (hPSC) myogenic differentiation protocols and mapped hPSC-derived myogen

263 Current differentiation protocols generate heterogeneous neural

264 Moreover, differentiation protocols usually result in partly diffe

265 This approach identified Endothelial differentiation-related factor 1 (EDF1) as a novel prote

266 PTPN14 CRISPR knockout repress keratinocyte differentiation-related genes.

267 rization and myeloid-derived suppressor cell differentiation, respectively, most likely in a TLR2-dep

268 te stem cells to show similar Ca(++)-induced differentiation, resulting in increased 5-hmC levels and

269 f IL-33-ST2 signaling on monocyte/macrophage differentiation, self-renewal and repairing ability, as

270 e-wide methylation changes are transduced to differentiation skews through biases in CpG enrichment o

271 Differentiation stage and immune-effector functions of t

272 developing techniques to purify and profile differentiation stage-matched late erythroblast F cells

273 Its differentiation starts at gastrulation, when the epiblas

274 endothelial cells (ECs) present early in HIO differentiation that declines over time in culture.

275 tivity of phenformin to promote keratinocyte differentiation that warrants future translational effor

276 e with gene transcript levels, however, upon differentiation the global increase in 5hmC content show

277 phogenetic furrow that marks the front of PR differentiation, the migrating SG contact the nascent PR

278 trabecular bone loss by enhancing osteoclast differentiation through enhanced TNFalpha signaling.

279 s, we postulate that 3-MPA promoted myogenic differentiation through the inhibition of PEPCK-M.

280 landscapes with both genetic diversity, and differentiation to gain a more comprehensive understandi

281 Gametocytes differentiation to gametes (gametogenesis) within mosqui

282 LMP1-expressing B cells by inhibiting their differentiation to plasma cells.

283 ted away from nuclear receptors that promote differentiation towards beta-catenin, a driver of prolif

284 These in turn skew differentiation towards the tumor cell-of-origin and alt

285 ing of activated B cells and construction of differentiation trajectories reveal an early cell fate b

286 Clear differentiation was achieved between specimens from infe

287 To analyze human Purkinje cell (PC) differentiation, we optimized a protocol to generate hum

288 ate lymphoid cell activation, and T(h)2 cell differentiation were found in gut mucosa of mice nursed

289 eover, cell mechanical features and myogenic differentiation were significantly reduced in shPAB cell

290 ns, modestly reduced the efficiency of spore differentiation whereas spores were nearly absent in the

291 oxb1 in embryonic stem cells arrests cardiac differentiation, whereas Hoxb1-deficient mouse embryos d

292 ng in human CD34+ cells reduced granulocytic differentiation, whereas its activation enhanced myelopo

293 -protein activities while showing expression differentiation, wherein BjuA.Galpha1 was the highly abu

294 icient to convey support for oligodendrocyte differentiation while this support was lost by EVs from

295 he Ealpha enhancer at early stages of T cell differentiation, while their decommission is required fo

296 e studied GLS2 expression after induction of differentiation with phorbol ester (PMA) and transductio

297 DENV-infected MEG-01 cells, when induced for differentiation with PMA, supported an enhanced viral re

298 an provide spatiotemporal coordination of WG differentiation with the progressive differentiation of

299 enesis is directed by morphogens that induce differentiation within a defined tissue geometry.

300 minishes enzymatic activity and granulocytic differentiation without significantly affecting cell pro