ライフサイエンスコーパス: differentiation potential

1 tentially overcoming differences in PSC line differentiation potential.

2 ing progenitors with a predominant monocytic differentiation potential.

3 blasts had approximately 50% lower adipocyte differentiation potential.

4 bryonic tissue while maintaining a versatile differentiation potential.

5 aneous loss of pluripotency, and compromised differentiation potential.

6 engineer progenitor cells with multilineage differentiation potential.

7 r cell duplication in populations with equal differentiation potential.

8 oth phenotypes and restored normal stem cell differentiation potential.

9 opoietic progenitors to establish their full differentiation potential.

10 th preserved long-term in vivo lymphomyeloid differentiation potential.

11 ntify the lines exhibiting strong osteogenic differentiation potential.

12 population studied as HSPCs with multlineage differentiation potential.

13 fered in their metabolic characteristics and differentiation potential.

14 ssures favouring cell aneuploidy and loss of differentiation potential.

15 MSC marker profile and in vitro multilineage differentiation potential.

16 the presence of close analogues with varying differentiation potential.

17 itor cells with self-renewal and multipotent differentiation potential.

18 eptor antagonist resulted in altered myeloid differentiation potential.

19 stem cells are considered to have a limited differentiation potential.

20 ither DPSC proliferation rate or multipotent differentiation potential.

21 hematopoietic progenitors and had bilineage differentiation potential.

22 on, exhibit differences in proliferation and differentiation potential.

23 mbryonic stem cell phenotype and pluripotent differentiation potential.

24 e proliferation ability, thus changing their differentiation potential.

25 hondria and require UCP2 repression for full differentiation potential.

26 in genome-wide DNA methylation profiles and differentiation potential.

27 ting a progressive decrease in hematopoietic differentiation potential.

28 ant proliferative, chemotaxis, adhesion, and differentiation potential.

29 e capacity for self-renewal and multilineage differentiation potential.

30 cells yet differ in molecular phenotype and differentiation potential.

31 yeloid progenitors (EMPs) that lack lymphoid differentiation potential.

32 sider implications for hESC pluripotency and differentiation potential.

33 but not their maintenance, proliferation or differentiation potential.

34 ike cells have self-renewal and multilineage differentiation potential.

35 prethymic, age-related defects in T-lineage differentiation potential.

36 vels of endoglin (NCSC(CD105+)) had myogenic differentiation potential.

37 accelerates maturation and polarizes hES-NSC differentiation potential.

38 in Lmna(-/-) myoblasts resulted in increased differentiation potential.

39 er the JAK2 V617F-positive cells had altered differentiation potential.

40 derived stem cells (ADSCs) have multilineage differentiation potential.

41 -derived pluripotent stem cells with a broad differentiation potential.

42 mpaired differentiation kinetics and reduced differentiation potential.

43 enerated uncommitted cells with multilineage differentiation potential.

44 ed this compartment, but retain multilineage differentiation potential.

45 a transformed phenotype and disrupting their differentiation potential.

46 o establish new stage- or cell-type-specific differentiation potential.

47 developmental stage thymocytes lose this G/M differentiation potential.

48 planted into syngeneic rats to examine their differentiation potential.

49 played less CD45RA, and had little B-lineage differentiation potential.

50 an ongoing immune response, regardless of Th differentiation potential.

51 pRB(-/-) 3T3 cells exhibit defects in their differentiation potential.

52 cytic progenitor with intrinsic biphenotypic differentiation potential.

53 iciency does not abrogate myeloid progenitor differentiation potential.

54 C) are cells with self-renewing multilineage differentiation potential.

55 clonogenic potential and increased B-lineage differentiation potential.

56 HSPCs), without impairing cell viability and differentiation potential.

57 d allows the ranking of cells based on their differentiation potential.

58 n (STAT) 3 signaling pathway, and osteogenic differentiation potential.

59 ) cell derived SG-MSCs revealed multilineage differentiation potential.

60 l, serial clonogenicity, and multigerm layer differentiation potential.

61 LMPP/MPP4 with loss of lymphoid priming and differentiation potential.

62 progenitor cell populations with restricted differentiation potential.

63 markers and demonstrated robust mineralizing differentiation potential.

64 ed MSCs for self-renewal, proliferation, and differentiation potential.

65 is regulated by progenitor availability and differentiation potential.

66 eased cell death or altered neural precursor differentiation potential.

67 teoblastogenic, chondrogenic, and adipogenic differentiation potentials.

68 ughter cells with differing self-renewal and differentiation potentials.

69 cells that may reflect molecular priming of differentiation potentials.

70 either A-type lamins or emerin have impaired differentiation potentials.

71 fibroblasts possessed trilineage mesenchymal differentiation potentials.

72 ogenic assays were used to investigate their differentiation potentials.

73 are defined by self-renewal and multilineage differentiation potentials.

74 ctive of tissue of isolation, equal in their differentiation potential?

75 iple BM populations have intrinsic T lineage differentiation potential, a small subset of multipotent

76 mice, displaying increased proliferation and differentiation potentials (adipogenesis, osteogenesis a

77 marrow cells containing lymphoid-restricted differentiation potential after i.v. transplantation.

78 ulated young mice, and retained multilineage differentiation potential after multiple rounds of seria

79 aracteristics in vitro and proliferative and differentiation potential after transplantation into adu

80 Full differentiation potential along with self-renewal capaci

81 gramming event to acquire a remarkably broad differentiation potential and ability to migrate through

82 parthenogenesis and demonstrated their wide differentiation potential and applicability for genetic

83 om hESCs (hESCd-MSCs) that have multilineage differentiation potential and are capable of producing f

84 teoclasts from BgnFmod KO mice having higher differentiation potential and being more active compared

85 oid progenitors exhibiting CD14-dependent DC differentiation potential and CD14(+)CD1a+ DC precursors

86 om both sources exhibited similar trilineage differentiation potential and cell surface marker expres

87 ryonic progenitor cells with hemangioblastic differentiation potential and conclude that embryonic pr

88 These progenitor cells demonstrated bipotent differentiation potential and could generate endothelial

89 cells differ from each other with respect to differentiation potential and fates.

90 prisingly, GPx2-suppressed cells also lacked differentiation potential and formed slow-growing undiff

91 While both cell types show similar differentiation potential and forward scatter values, th

92 Understanding the differentiation potential and function of these cells ma

93 monocyte subpopulations, understanding their differentiation potential and function.

94 on therapies by virtue of their multilineage differentiation potential and immunogenicity; however, r

95 ntense investigation in HCT because of their differentiation potential and immunomodulatory propertie

96 multipotent cells with in vitro multilineage differentiation potential and in vivo engraftment potent

97 al, and had normal transcriptional profiles, differentiation potential and karyotypes.

98 ells, with which they share gene expression, differentiation potential and lineage restriction.

99 engthy protocols or a progressive decline in differentiation potential and physiological function wit

100 n knockout cells decreased proliferation and differentiation potential and recapitulated the WT pheno

101 tant in defining cellular properties such as differentiation potential and responsiveness to developm

102 on of lung progenitor markers, multi-lineage differentiation potential and self-renewal activity.

103 iding with a reduction in both smooth muscle differentiation potential and TGFbeta1 responsiveness.

104 cific stem/precursor cells that retain broad differentiation potential and, more importantly, develop

105 ain long-term repopulation and multi-lineage differentiation potential, and can improve biochemical a

106 gle-cell assays of HSC quiescence, stemness, differentiation potential, and epigenetic state to probe

107 in an intermediate state with bidirectional differentiation potential, and found the balance between

108 rbor an appropriate gene edit, pluripotency, differentiation potential, and genomic stability are typ

109 re the most proliferative, hold the greatest differentiation potential, and have the lowest rate of c

110 ity of the hemangioma stem cells, diminishes differentiation potential, and inhibits the vasculogenic

111 h passage 11 for phenotype, gene expression, differentiation potential, and karyotype.

112 at histone H3 serine 10 (H3S10P), decreased differentiation potential, and premature cellular senesc

113 e have distinct patterns of gene expression, differentiation potential, and response to environmental

114 itors are hyperproliferative, show decreased differentiation potential, and show increased self-renew

115 + CD38- progenitor cells have a multilineage differentiation potential, and that Tpo promotes prolong

116 itor populations with granulocyte/macrophage differentiation potential are efficiently immortalized i

117 rs that regulate cancer stem-like cell (CSC) differentiation potential are largely unknown.

118 rs did not restrict, but rather switch their differentiation potential as they developed.

119 scaffolds exhibit an increase in osteogenic differentiation potential, as evidenced by increased alk

120 progenitor populations for T cell growth and differentiation potential, as well as for clonogenic T o

121 riability of their osteogenic and adipogenic differentiation potential, as well as their ability to m

122 rimitive human progenitors with multilineage differentiation potential, as well as to evaluate future

123 the dissociated cells retained their normal differentiation potentials, as shown by their capabiliti

124 hagocytic activity, and a greater osteoclast differentiation potential at suboptimal RANK-L concentra

125 ested that bone marrow cells possess a broad differentiation potential, being able to form new liver

126 ndrogenic potential assays revealed retained differentiation potentials between transduced and wild-t

127 ariability in frequency, immunophenotype and differentiation potential, both between and even within

128 ers of haematopoietic stem cells with normal differentiation potential, but loss of cell-autonomous s

129 Ps, with very limited granulocyte/macrophage differentiation potential, but they can differentiate in

130 ssemble HC variable region genes and assayed differentiation potential by recombination activating ge

131 development cells become restricted in their differentiation potential by repressing alternative cell

132 n impaired, however, in determining cellular differentiation potentials by a lack of short-term funct

133 7, and CD94 cell surface expression, lineage differentiation potentials, capacity for cytokine produc

134 ogeneous, and displays distinct multilineage differentiation potential, cell cycle profile, prolifera

135 ibited increased TRPV4 activity and enhanced differentiation potential compared with normal human lun

136 d from TRPV4-knockout mice showed diminished differentiation potential compared with wild-type mice.

137 e less quiescent, and exhibit myeloid-biased differentiation potential compared with young HSC.

138 ple distinct subsets that display growth and differentiation potential consistent with being canonica

139 ervoir of CD45-CD34(+) EPCs with endothelial differentiation potential, containing a mean of 263 time

140 yed differences in fate-regulating genes and differentiation potential depending on their rostrocauda

141 lls affected by BRAF mutation had a range of differentiation potentials depending on exogenous signal

142 In PSCs with lower differentiation potential, DNA replication was incomplet

143 subunit Dpf2 maintains pluripotency and ESC differentiation potential. Dpf2 co-occupies enhancers wi

144 the sequential loss of erythroid and then GM differentiation potential during early hematopoiesis.

145 genitors are protean and able to alter their differentiation potential during embryogenesis and after

146 oietic cells are tightly restricted in their differentiation potential during mouse embryo developmen

147 rm self-renewing capacities and multilineage differentiation potential during physiological and regen

148 pression for protecting stem cells and their differentiation potential during viral infection.

149 ation capacity and restricted cardiovascular differentiation potentials during cardiac transdifferent

150 pacity in vivo but completely lacked myeloid differentiation potential either in vivo or in vitro.

151 n upon which TSCs are cultured changes their differentiation potential from TGCs to multinucleated sy

152 g progenitor cells, and possess multilineage differentiation potential generating functional prostati

153 To this end, we examined differentiation potential, global gene expression patter

154 culture and transplantation assays to assess differentiation potential have led to extraordinary prog

155 id cell lines with neutrophil and macrophage differentiation potential in about 50% of the infected c

156 Thus, B2 cells have B1 cell differentiation potential in addition to their classical

157 isoform preferentially blocks rhabdomyoblast differentiation potential in cell culture and in vivo.

158 potent stem cells (hiPSCs) with wide lineage differentiation potential in culture.

159 cells retain age-related stem- and endocrine-differentiation potential in culture.

160 anscription factors and surface markers, and differentiation potential in embryoid body formation and

161 ts expression levels correlate with fat cell differentiation potential in humans.

162 Single BASCs had bronchiolar and alveolar differentiation potential in lung endothelial cell cocul

163 s the balance of myeloid versus T lymphocyte differentiation potential in lymphomyeloid-primed progen

164 amycin targets the self-renewal and vascular differentiation potential in patient-derived hemangioma

165 CD29(low) luminal progenitors with enhanced differentiation potential in vitro and in vivo.

166 r to bone marrow HSPCs and have multilineage differentiation potential in vitro and in vivo.

167 FP mice and evaluate their proliferative and differentiation potential in vitro.

168 ted long-term proliferation and multilineage differentiation potential in vitro.

169 perties in vitro and their proliferative and differentiation potential in vivo after transplantation

170 rogenitor cells; however, their identity and differentiation potential in vivo remain poorly characte

171 Lymphoid-specified MPPs have low myeloid differentiation potential in vivo, but potently differen

172 inocyte subpopulations with increased growth/differentiation potential, including clonal growth capab

173 ely impact either clonogenic or multilineage differentiation potential, indicating a selective depend

174 pe and possessing unlimited self-renewal and differentiation potential, induced pluripotent stem cell

175 bility with respect to CHCHD2 expression and differentiation potential is caused by clonal variation

176 Their migration pattern and differentiation potential is distinct from anterior fore

177 At each stage, lineage differentiation potential is restricted, coupled with th

178 impact of genetic modifications on relative differentiation potential, it is now evident that a bias

179 Cell clones were evaluated for their O/C differentiation potential, metabolic activity, and expre

180 To evaluate their differentiation potential, NEPECs were heritably marked

181 tential in myoblasts, the augmented myogenic differentiation potential observed is likely the result

182 The differentiation potential of 17 human embryonic stem (hE

183 r, the EVE had no effect on proliferation or differentiation potential of adipose stem cells.

184 se model can be a valuable tool to study the differentiation potential of adult human stem cells.

185 o the mammary epithelial hierarchy, the true differentiation potential of adult MaSCs remains unclear

186 Here, we show that the differentiation potential of adult rodent OPCs decreases

187 The multilineage differentiation potential of adult tissue-derived mesenc

188 Impaired lymphoid differentiation potential of aged LMPP/MPP4 is not rescu

189 We examined the differentiation potential of an adult liver stem cell li

190 f B-ALL and suggest that engaging the latent differentiation potential of B-ALL cells may provide new

191 reduction in the frequency and self-renewal/differentiation potential of basal MaSCs.

192 The differentiation potential of BECs and LECs in vivo and i

193 itutive Notch activity suppresses the acinar differentiation potential of CACs.

194 rs influence the epigenetic conformation and differentiation potential of cells during reprogramming

195 Here, we examined the differentiation potential of cells expressing such linea

196 ells; however, CTGF is down-regulated as the differentiation potential of committed pre-osteoblasts i

197 3 is required for both the proliferative and differentiation potential of developmentally mature kera

198 ted gene expression to the proliferation and differentiation potential of early human bone marrow lym

199 egies should concentrate on manipulating the differentiation potential of endogenous or exogenous pre

200 The phenotype characteristics and differentiation potential of enriched cells were analyze

201 Acute deletion of BAF250a disrupted the differentiation potential of ES cells by altering the ex

202 C self-renewal, but significantly alters the differentiation potential of ESCs, particularly along th

203 The differentiation potential of GRP cells is retained throu

204 of the human hair follicle that preserve the differentiation potential of HAP stem cells.

205 The B cell differentiation potential of HNF1A(-/-) common lymphoid

206 the retinoblastoma protein and enhances the differentiation potential of hPSCs across all germ layer

207 ythroid, accompanied by a parallel change in differentiation potential of HSC/MPPs, which we function

208 The self-renewal and differentiation potential of human embryonic stem cells

209 nted here offer new tools for harnessing the differentiation potential of human ESCs.

210 f this study was to characterize the cardiac differentiation potential of human iPS cells generated u

211 mmunophenotype, transcriptional profile, and differentiation potential of individual MEP cells.

212 or formation and a determinant of the growth/differentiation potential of keratinocyte subpopulations

213 layed differentiation kinetics and decreased differentiation potential of lamin A/C-deficient and eme

214 e expression of premarked genes and enhanced differentiation potential of Lsh(-/-) iPS cells toward t

215 The differentiation potential of mouse embryonic stem cells

216 beta-catenin in mouse osteoblasts alters the differentiation potential of myeloid and lymphoid progen

217 r observe enhanced unbiased lineage-specific differentiation potential of naive hESCs converted in NC

218 The differentiation potential of NCC varies according to the

219 We tested the growth and differentiation potential of NCSCs at approximately 5% O

220 ng the TBI-responsive migratory behavior and differentiation potential of neural progenitor cells (NP

221 challenged by reports that showed a broader differentiation potential of neural stem cells, in vitro

222 When the differentiation potential of NG2+ cells in vitro was exa

223 iological changes in OPCs correlate with the differentiation potential of OPCs; thus, they may underl

224 ciated previously with the proliferation and differentiation potential of OPs.

225 sion seems to correlate with neuroectodermal differentiation potential of pluripotent stem cells.

226 ce and differentiation, we have analyzed the differentiation potential of progenitors derived from em

227 l blood indices, and corrected the defective differentiation potential of progenitors in the erythroi

228 etic progenitor assays demonstrated that the differentiation potential of PV was already skewed towar

229 To examine the self-renewal and differentiation potential of Rad-NSCs in vivo, Rad-NSCs

230 The ability to quantify differentiation potential of single cells is a task of c

231 In this study, we analyzed the differentiation potential of single thymocytes from wild

232 rm-free mice display reduced proportions and differentiation potential of specific myeloid cell proge

233 neity in G1 length underlies the pluripotent differentiation potential of stem cell populations.

234 The differentiation potential of stem cells is influenced by

235 ether an open chromatin is necessary for the differentiation potential of stem cells, and which molec

236 e demonstrate the in vitro proliferative and differentiation potential of stem/progenitor cells, adul

237 The differentiation potential of T lineage cells becomes res

238 MISTRG MDS-PDX demonstrate the cytotoxic and differentiation potential of targeted therapeutics provi

239 In short, slower proliferation and abnormal differentiation potential of tetraploid ESCs might be tw

240 g the dKO-nmMSCs with dKO-MPCs, the myogenic differentiation potential of the dKO-MPCs was reduced.

241 nce even low vector expression may alter the differentiation potential of the iPSCs or induce maligna

242 The viability, proliferation rate, and differentiation potential of the labelled cells were the

243 Zeb2 genetic inactivation impaired the differentiation potential of the V-SVZ niche in a cell-a

244 The relatively uniform differentiation potential of the Wnt(high) and Wnt(low)

245 The origin and growth/differentiation potential of these c-kit-positive cells

246 decreasing average mechanical compliance and differentiation potential of these cells, although expre

247 han nonpolar progenitors, leading to a lower differentiation potential of these cells.

248 f KLRG1(+) ILCs is consistent with the broad differentiation potential of these cells.

249 The differentiation potential of these MSCs combined with ex

250 that cellular origin influences the in vitro differentiation potentials of iPSCs into embryoid bodies

251 howed a direct correlation between DDIT4 and differentiation potentials of MSC.

252 ibute to genomic instability and the diverse differentiation potentials of reprogrammed PSCs.

253 lations often have reduced proliferation and differentiation potential, or have become immortalized c

254 expressed EphB4 in cell lines of restricted differentiation potential promoted megakaryocytic differ

255 g and comparing the hiPSC clonal and/or line differentiation potential provides a tool for large scal

256 ed-HSCs (iHSCs), possess clonal multilineage differentiation potential, reconstitute stem/progenitor

257 een claimed to possess an unexpectedly broad differentiation potential (referred to here as plasticit

258 progenitor pool of spermatogonia, markers of differentiation, potential regulators of meiosis, RNA tu

259 To test whether these changes in Th cell differentiation potential rendered Grb2(fl/fl) CD4cre(tg

260 Finally, to confirm the differentiation potential, reporter human iPS clones wer

261 ic cells are expected to possess high growth/differentiation potential, required for organ morphogene

262 Furthermore, CCR9(+) MPPs possess differentiation potential similar to that of ETPs, with

263 en their unique function in self-renewal and differentiation potential, stem cells might be used to r

264 tion defect with minimal effect on erythroid differentiation potential, suggesting the mechanism of a

265 neurons, the two hESC lines exhibit distinct differentiation potentials, suggesting that they are pre

266 eir genomic instability and diminishes their differentiation potential, supporting the notion that ac

267 enewing progenitor with limited multilineage differentiation potential termed the erythromyeloid prog

268 intain a latent granulocyte/macrophage (G/M) differentiation potential that can be initiated by signa

269 However, they maintain a latent myeloid differentiation potential that can be initiated by stimu

270 ns house pools of SCs with proliferative and differentiation potentials that diverge from this templa

271 sively without obvious senescence or loss of differentiation potential, they may be an ideal cell sou

272 that become increasingly restricted in their differentiation potential through oligopotent and then u

273 t nuclear reprogramming can restore terminal differentiation potential to human-derived cancer cells,

274 elopmental plasticity, thereby expanding the differentiation potential to include the neuronal lineag

275 F4 or FGF2 together with heparin rescued the differentiation potential to neural progenitors and furt

276 l brain tumors are similar in appearance and differentiation potential to neural stem and progenitor

277 (termed R-NSCs), a novel NSC type with broad differentiation potential toward CNS and PNS fates and c

278 In addition, these SCs show differentiation potential toward mesenchymal lineages, a

279 d both neuronal and glial progeny, but their differentiation potential toward multiple region-specifi

280 erative medicine has been to direct the wide differentiation potential toward the derivation of a spe

281 stem cells (hESCs) have different and biased differentiation potentials toward either neuroectoderm o

282 Although early pro-B cells have lost myeloid differentiation potential, transplantation experiments d

283 during hematopoiesis, with stepwise loss of differentiation potential ultimately resulting in lineag

284 helial SCs, their tissue location, and their differentiation potential under physiological conditions

285 scence and maintained their multipotency and differentiation potential until passage 11 and beyond.

286 Thus, IRF8 not only bestows monocyte and DC differentiation potential upon mononuclear phagocyte pro

287 ght, we assessed relative tumorigenicity and differentiation potential via xenotransplantation.

288 Differentiation potential was evaluated by injecting cel

289 Differentiation potential was examined for changes in ph

290 Monocytic cell differentiation potential was retained in left-shifted b

291 Differentiation potential was tested in novel, single-ce

292 Six imidazole derivatives with high kinase differentiation potential were identified.

293 D repopulating cells (SRC) with multilineage differentiation potential were maintained in FL-SCF-IL-7

294 ing fibrocytes, with greater myofibroblastic differentiation potential, were observed in patients wit

295 thelial cells (hAECs), which possess hepatic differentiation potential, were transplanted into the mi

296 previously showed that they acquire broader differentiation potential when cultured under embryonic-

297 cdpk3- ookinetes maintain their full genetic differentiation potential when microinjected into the mo

298 rogenitors (CLPs), maintain a latent myeloid differentiation potential, which can be initiated by sti

299 oblasts fail to proliferate but retain their differentiation potential, while deletion of Mll2 had no

300 ain long-term repopulation and multi-lineage differentiation potential with serial transplantation.