ライフサイエンスコーパス: differentiation state

1 ith sensitivity to DNA damage, was linked to differentiation state.

2 e from which MCs may be derived and/or their differentiation state.

3 nes regardless of the somatic cell source or differentiation state.

4 loss in DLBCL is associated with an altered differentiation state.

5 exhausted CD8 T cells become fixed in their differentiation state.

6 ct or cooperate to regulate tumor growth and differentiation state.

7 ion by interfering with the mature beta-cell differentiation state.

8 ytokine cascades that correlate with each Th differentiation state.

9 tionship between the replication program and differentiation state.

10 reas hiPSC-derived RPE cells are in a unique differentiation state.

11 ain their expression, thereby locking in the differentiation state.

12 r CD57, a finding consistent with an earlier differentiation state.

13 according to the stage of the cell cycle and differentiation state.

14 o transition from a proliferative state to a differentiation state.

15 nd has distinct consequences on the cellular differentiation state.

16 lls progress from a naive to a primed/memory differentiation state.

17 Id1 degradation are independent of myogenic differentiation state.

18 that pigpen helps regulate endothelial cell differentiation state.

19 expression depends on cell type and cellular differentiation state.

20 rdless of host species, tissue of origin, or differentiation state.

21 llular signals causing phenotypic changes in differentiation state.

22 t correlated with cell cycle distribution or differentiation state.

23 ddiction paradigm on the basis of tumor cell differentiation state.

24 h similar expression profiles share the same differentiation state.

25 for variant effects across any hematopoietic differentiation state.

26 ard a more beneficial memory-like CD8 T cell differentiation state.

27 nning generations, sexes, ontogeny, and cell differentiation state.

28 o modulate liposarcoma cell survival and ASC differentiation state.

29 choring mechanisms depending on the neuronal differentiation state.

30 on on EVT, presumably representing a further differentiation state.

31 with the latter independently of the T cell differentiation state.

32 atures to explore cell-cell interactions and differentiation state.

33 tion at the ECM and governed by the cellular differentiation state.

34 ression are modified by cellular context and differentiation state.

35 lly eradicate cancer cells across a range of differentiation states.

36 the stability and reversibility of cellular differentiation states.

37 collected from multiple lineages at diverse differentiation states.

38 n ability to target macrophages in different differentiation states.

39 an association between T-cell clonotypes and differentiation states.

40 r, little is known about their phenotype and differentiation states.

41 pmental dynamics denoting two projections of differentiation states.

42 t B cell proliferation over a broad range of differentiation states.

43 acquisition of specific effector and memory differentiation states.

44 istence, and environment-resulting in myriad differentiation states.

45 lly applicable to other TLRs, cell types, or differentiation states.

46 genes in the proliferation and post-mitotic differentiation states.

47 te immune cell epigenomes to engage specific differentiation states.

48 its expression in different B cell lineages/differentiation states.

49 s similarly made up of cells in a variety of differentiation states.

50 onal signatures that define and regulate CTL differentiation states.

51 (1) acquiring a fully functional, pathogenic differentiation state, (2) secreting significant amounts

52 6 and subplate neurons maintain an immature differentiation state, abnormally expressing these genes

53 ced by targeted therapy can provoke distinct differentiation-state aggregations of drug-resistant cel

54 ctivity of TGF-beta is modulated by the cell differentiation state and by the presence of inflammator

55 Here, we study the differentiation state and cellular origin of 1300 childh

56 g drives distinct responses depending on the differentiation state and context of CD8(+) T cells.

57 flect the cellular proliferative ability and differentiation state and deserve further studies as pot

58 posite effect, perturbing maintenance of the differentiation state and facilitating reprogramming to

59 posttransplant period then maintained their differentiation state and functional capacity despite po

60 pe, mechanics, and deformability change with differentiation state and have been likewise implicated

61 nstream effects of SMARCB1 loss depending on differentiation state and identified an interaction betw

62 s a prominent role for syk in regulating the differentiation state and invasive phenotype of PDAC cel

63 LPP3 expression regulates SMC differentiation state and lowering LPP3 levels promotes

64 ibitor is predicted based on melanoma cells' differentiation state and MAPK activity.

65 eir cell of origin, providing clues into the differentiation state and origin of cancer.

66 nt within this nonlymphoid tissue shapes the differentiation state and persistence of the central and

67 ays an active role to reinforce the impaired differentiation state and promote malignancy.

68 The differentiation state and regulatory pathways that enabl

69 ated GLI2 levels, thereby regaining the full differentiation state and restoring normoglycemia in tra

70 oblastoma prognosis is dependent on both the differentiation state and stromal content of the tumor.

71 investigate the role of IRF4 for maintaining differentiation state and survival of CD8(+) memory T ce

72 cence mimics a cell cycle-dependent drift in differentiation state and that propagation of HDF in his

73 , underlying the significance of chondrocyte differentiation state and the factors regulating normal

74 eosome stability and PTMs across cell types, differentiation state and throughout the cell-cycle in c

75 effector subsets is contingent on both their differentiation state and tissue localization.

76 lved in the regulation of breast cancer cell differentiation state and tumorigenicity.

77 s method paves the way for defining granular differentiation states and cell subtypes from transcript

78 CD8(+) T cells retain terminal effector (TE) differentiation states and fail to mature into protectiv

79 n immune homeostasis in the brain, yet their differentiation states and functional capabilities remai

80 analyses of markers associated with cellular differentiation states and genotypic alterations in huma

81 toimmune CD8 T cells represent unique T cell differentiation states and identified features driving t

82 define a close association between GBM cell differentiation states and invasion routes, identify fun

83 rappreciated heterogeneity of malignant cell differentiation states and presumed cell of origin, and

84 s revealed previously unappreciated distinct differentiation states and progenitor subpopulations tha

85 ve accuracy of SLICE in determining cellular differentiation states and reconstructing cell different

86 We determined differentiation states and targets of dominant T-cell cl

87 xhibit both heterogeneity and instability of differentiation states and varying sensitivities of thes

88 SK/JKs displayed altered differentiation states and were enriched for effector cy

89 We therefore determined the lineage, differentiation state, and functional potential of FL-in

90 The activation state, differentiation state, and functions of liver lymphocyte

91 We investigated the existence, differentiation state, and neoplastic potential of CD66(

92 at Lbx1 expression defines a basal GABAergic differentiation state, and Tlx3 acts to antagonize Lbx1

93 ith replicative age, chronological age, cell differentiation state, and/or overall worm physiological

94 signatures that represent specific lineages, differentiation states, and functions.

95 calization within tissues is linked to their differentiation states, and this may identify anatomical

96 the number of transferred T cells and their differentiation state are critical determinants of effec

97 ature, suggesting that programs that control differentiation state are key determinants of spatiotemp

98 orts, we found that MDS HSCs in two distinct differentiation states are maintained throughout the cli

99 s in tissue culture is dependent both on the differentiation state as well as exposure to soluble med

100 naling, metabolism, structure and lineage or differentiation state as well as imposed factors, the mo

101 Recently, we showed that plasticity between differentiation states, as identified with intracellular

102 exists across species, cell types, and cell differentiation states, as well as when cells are placed

103 s (RAGE), promote chondrocyte hypertrophy, a differentiation state associated with matrix catabolism.

104 iated SH-SY5Y cells and samples clustered by differentiation state at the gene and isoform level.

105 ctor, and transplanted similarly at the same differentiation state, at the same time and location, in

106 d into three subtypes, on the basis of their differentiation states: basal, intermediate, and differe

107 cRNA-seq) to quantitatively measure cellular differentiation states based on single cell entropy and

108 s thought to involve a compromised beta cell differentiation state, but the mechanisms underlying thi

109 ated role for methyltransferases in cellular differentiation states by direct posttranslational modif

110 This differentiation state can be modulated by preexisting me

111 Their differentiation state can be regulated by serum response

112 -grade gliomas, HAVOC revealed that distinct differentiation states can often coexist and be regional

113 TAMs, depending on their differentiation state, can exhibit pro- or antitumorigen

114 en, cytotoxic CD8(+) T cells develop diverse differentiation states characterized by function, locali

115 neuroanatomical detail due to the progressed differentiation state compared to earlier stages.

116 ponse to infection, T cells adopt a range of differentiation states, creating numerous heterogeneous

117 o activate transcription in a cell type- and differentiation state-dependent manner.

118 ion that is essential for the cell cycle and differentiation state-dependent onset of human cytomegal

119 the importance of this molecular switch for differentiation state-dependent regulation of IE gene ex

120 rogenitor cell-derived LC-type DCs exhibit a differentiation state-dependent susceptibility to CMV in

121 substantially up-regulated in a cortisol and differentiation-state-dependent manner.

122 into epithelial-mesenchymal interactions and differentiation state differences within the RA biosynth

123 Heterogeneity in differentiation state due to epigenetic plasticity, howe

124 t, miR-29a fostered a memory-like CD8 T cell differentiation state during chronic infection.

125 ies suggest that the maintenance of the vein differentiation state during pupal development involves

126 Here, we leveraged the well-defined differentiation states during T-cell development to pinp

127 Here, we review new insights into differentiation state dynamics and population heterogene

128 e distinct BC subtypes on the basis of their differentiation states, each harboring a unique tumor-in

129 T cells can acquire a broad spectrum of differentiation states following activation.

130 orm of thymic selection or as an alternative differentiation state for Ag-exposed T cells.

131 000 normal breast cells, which identified 11 differentiation states for normal luminal cells.

132 ational framework (CytoTRACE) for predicting differentiation states from scRNA-seq data.

133 Exhausted cells exist in multiple differentiation states, from stem-like progenitors that

134 diversity of cell types that are defined by differentiation states, genetic mutations and altered ep

135 rtments where they reversibly enter distinct differentiation states governed by local microenvironmen

136 e transcriptional regulation of other T cell differentiation states has provided critical information

137 chanism of cellular communication, roles for differentiation state heterogeneity in pigment cell inte

138 al that T cell subsets can synchronize their differentiation state in a process similar to quorum sen

139 the LMI approach can detect known changes of differentiation state in both normal and malignant hemat

140 h a granulo-monocytic-biased transcriptional differentiation state in MDS patients who initially resp

141 ancreas are not static, but can change their differentiation state in response to injury or stress.

142 nitor cells and remained expressed until the differentiation state in the mature plant, suggesting a

143 en attributed to CD8(+) T cell exhaustion, a differentiation state in which T cells have reduced and

144 re oncogenic signaling, cell phenotypes, and differentiation states in a high-dimensional single-cell

145 able proliferation and transition to earlier differentiation states in CONV.

146 l, and non-basal/non-luminal/non-mesenchymal differentiation states in HCC1143 cell populations.

147 The transition between stem and differentiation states in nonneoplastic cells requires m

148 pecific Vbeta and Valpha chains with varying differentiation states in response to Listeria monocytog

149 prolonged Ag stimulation in programming this differentiation state, including local stimulation via c

150 Moreover, T cell differentiation state influences how cues from the micro

151 lements of thyroid cancer biology, including differentiation state, invasive properties and the cellu

152 An abnormal differentiation state is common in BRCA1-deficient mamma

153 Glomerular podocyte differentiation state is critical for filtration barrier

154 ization and understanding of this macrophage differentiation state is needed in order to efficiently

155 ia and delineated the heritability of B cell differentiation states linked with genetic drivers.

156 , we review the intertwined nature of T cell differentiation state, location, survival and function,

157 underlie specific therapy-induced changes in differentiation-state marker expression that we recently

158 were derived with respect to histopathology, differentiation state markers, p16 status, and mutation

159 rating oocysts disregarding their growth and differentiation state may lead to erroneous conclusions

160 mbinations of factors that, depending on the differentiation state, might collaborate with MRFs.

161 receptors, Ptger4, was sufficient to drive a differentiation state morphologically and transcriptiona

162 age (CD8 > CD4) and a function of the memory differentiation state (naive T cells < central memory T

163 emonstrating a novel correlation between the differentiation state of a CD8(+) T cell and its abundan

164 oint to molecular mechanisms tailored to the differentiation state of a cell and the nature of recept

165 t with the hypothesis that the activation or differentiation state of a monocyte may have a substanti

166 as a model system to investigate whether the differentiation state of a polarized model epithelium af

167 gonist or by alteration of the activation or differentiation state of a susceptible cell such as a ma

168 ring PD-1/PD-L1 inhibition are linked to the differentiation state of a T cell.

169 Thus, the differentiation state of adult neurons is under the cont

170 pigenetic regulators may influence the final differentiation state of an osteosarcoma.

171 bal effect that HIV has on the activation or differentiation state of CD8 cells that are responsive t

172 The differentiation state of CD8+ T cells has emerged as a c

173 microenvironment exerts supremacy over prior differentiation state of cells in directing position-spe

174 Understanding the lineage and differentiation state of each cell is fundamentally impo

175 , we show that CD4(+) T cells can modify the differentiation state of EBV-transformed LCL.

176 f functional TGase 1 forms, depending on the differentiation state of epidermal keratinocytes.

177 E2 expression positively correlated with the differentiation state of epithelia.

178 demonstrate a close association between the differentiation state of GBM cells and their choice of i

179 , by targeting multiple genes regulating the differentiation state of GNPs, Atoh1 collaborates with t

180 CSPG manipulations shifted the stem versus differentiation state of HB cells, evident by their beha

181 ration Index (LMI), to define the changes in differentiation state of hematopoietic malignancies base

182 ks, we established a method to influence the differentiation state of hPSCs with a CRISPR-associated

183 motionless and foggy affect the number and differentiation state of hypothalamic DA, telencephalic

184 Remarkably, the differentiation state of individual BC progenitors at mi

185 The differentiation state of individual HCs in a test set co

186 (TOF-SIMS) data can be used to identify the differentiation state of individual hematopoietic cells

187 latory activity of IL-21 is modulated by the differentiation state of its target cells as well as by

188 m the Raman spectra can be used as marker of differentiation state of mES cells.

189 teractions as a mechanism for regulating the differentiation state of migrating cells.

190 e signaling from keratinocytes regulates the differentiation state of myofibroblasts.

191 found to change dynamically depending on the differentiation state of neural precursor cells.

192 We further show that the differentiation state of normal cells-of-origin is a str

193 The differentiation state of osteosarcomas has therefore bec

194 with the effects of E2F4, which enhances the differentiation state of PC12 cells without affecting ce

195 at mitosis is not arbitrary but matches the differentiation state of post-mitotic BCs in their surro

196 Exit from the cell cycle into a pre-differentiation state of post-mitotic growth arrest was

197 serum transfer altered the TCR diversity and differentiation state of responding T cells.

198 st that the effects of Ras signalling on the differentiation state of Schwann cells may be important

199 We therefore investigated its effects on the differentiation state of Schwann cells.

200 esis, and it plays a role in maintaining the differentiation state of secretory stage ameloblasts by

201 iated hESCs and fibroblasts to determine the differentiation state of stem-cell-derived RPE cells.

202 he antigenic signal and the developmental or differentiation state of the B cell, antigen receptor si

203 ggests that TCR usage is associated with the differentiation state of the CD8+ T cell response to YFV

204 at assaults on the beta cell that impact the differentiation state of the cell have clear implication

205 rs of transcription, varying by promoter and differentiation state of the cell.

206 ng on the nature of the signal and/or on the differentiation state of the cell.

207 y regulate caspase activation depends on the differentiation state of the cell.

208 differentially depending on cell type and/or differentiation state of the cell.

209 thway; this cross-regulation depended on the differentiation state of the cell: Akt activation inhibi

210 nges in [Ca2+]in levels) depends on both the differentiation state of the cells and concomitant engag

211 pidermal architecture, and the maturation or differentiation state of the cells.

212 However, we knew little about the differentiation state of the cultured granule cells that

213 e presence of blood flow correlates with the differentiation state of the developing pancreatic epith

214 ) from the melanoma cells that increased the differentiation state of the fibroblasts, an affect asso

215 BMP2 and BMP4 expression, independent of the differentiation state of the flanking chondrocytes.

216 llomavirus (HPV) life cycle is linked to the differentiation state of the host cell.

217 irus life cycle is intimately coupled to the differentiation state of the infected epithelium.

218 n state of tumors did not correlate with the differentiation state of the lineage of origin.

219 lation through CD28 or LFA-1, as well as the differentiation state of the lymphocyte, explaining how

220 her arrest or proliferation depending on the differentiation state of the melanocyte.

221 effect of OxLDL on SR-BI is dependent on the differentiation state of the monocyte/macrophage.

222 ne expression, is influenced markedly by the differentiation state of the muscle cell.

223 heir release, but also on the activation and differentiation state of the neighboring immune cells.

224 tion differed significantly depending on the differentiation state of the phagocyte, providing furthe

225 le for CD4+ T cells in disease; however, the differentiation state of the responsible T cells is uncl

226 To evaluate the differentiation state of the sinonasal epithelium in CRS

227 ling pathway are secondary to changes in the differentiation state of the surrounding mesenchyme.

228 through the same receptor, depending on the differentiation state of the T cell.

229 rognosis is closely linked to the underlying differentiation state of the tumor, ranging from the les

230 tumour proliferation rate, host response and differentiation state of the tumour.

231 ve, reflecting the developmental lineage and differentiation state of the tumours.

232 ion and histological osteoid production, the differentiation state of tumors did not correlate with t

233 The lineage-specific differentiation states of cells from these four subpopul

234 orrelate with the distinct proliferation and differentiation states of chondrocyte zones.

235 s express markers corresponding to the major differentiation states of epithelial cells in the breast

236 onses and may influence the proliferation or differentiation states of epithelial cells.

237 n for the detection of the many subtypes and differentiation states of immune cells.

238 using limited numbers of CD antigens enables differentiation states of immune system cells to be dete

239 SLICE successfully measured the differentiation states of single cells and reconstructed

240 n in the perichondrium correspond to altered differentiation states of the flanking chondrocytes.

241 anscriptional heterogeneity to normal B cell differentiation states of the human tonsil.

242 ous cancer cells that often resemble various differentiation states of their lineage of origin.

243 e the progenitor cell niche, we examined the differentiation states of two progenitor cell subtypes i

244 The role of cell differentiation state on hepatitis B virus (HBV) replica

245 ly infection events and the role of the cell differentiation state on such events.

246 plasticity, i.e., cells adaptively changing differentiation state or identity, is a central tissue r

247 owing either a spectrum of neural progenitor-differentiation states or glial and stem cell markers.

248 n which they can function as a group to mark differentiation states or individually as bona fide onco

249 ogeneity of functionally discrete and stable differentiation states, or conversely may be readily rev

250 cell identity with clonal lineages uncovers differentiation-state plasticity in leukemia, reconcilin

251 litates their ability to adopt heterogeneous differentiation states, posing a significant challenge t

252 It has been assumed that the somatic differentiation state provides a barrier for efficient r

253 cell signaling network remain coupled to the differentiation state, regardless of the presence of dri

254 athways mediating the switch between the two differentiation states remain unclear.

255 rance-induced states and other CD8(+) T cell differentiation states remains unclear.

256 delay in the transition between the distinct differentiation states required to support peripheral ne

257 ue-resident memory (Trm) CD8(+) T cells to a differentiation state resembling inflationary effector r

258 f-antigen triggered a fundamentally distinct differentiation state separate from exhaustion, memory,

259 sensitivity is governed broadly by AML cell differentiation state, sometimes conditionally affecting

260 n became linked to N-cadherin complexes in a differentiation-state specific manner.

261 We identified discrete cell-type and differentiation state-specific DNA methylation and gene

262 ets of normal human mammary cells could have differentiation state-specific functions and long-term c

263 eased autoantigen expression correlates with differentiation state, such that myositis autoantigen ex

264 protein degradation depends on the myogenic differentiation state (t 1/2 approximately 2 h in prolif

265 of IEC lead to an increased polarization and differentiation state that closely resembled the express

266 Tumour-specific CD8 T cell dysfunction is a differentiation state that is distinct from the function

267 keratin 14 (KRT14) marks the most primitive differentiation state that precedes KRT5 and KRT20 expre

268 ntieth century, the dominant model of sexual differentiation stated that genetic sex (XX versus XY) c

269 closely resembled granule neurons of varying differentiation states that correlated with patient age.

270 henotypically and transcriptionally distinct differentiation states, that is, less differentiated ear

271 oid cells by HSV-1 in vitro depends on their differentiation state; the outcome in vivo is unknown.

272 Related to differentiation states they have specific phenotypes and

273 transition from an epithelial-to-mesenchymal differentiation state through a process known as epithel

274 The contribution of lineage identity and differentiation state to malignant transformation is con

275 ransduction modulated mesenchymal fibroblast differentiation states to block those responses, instead

276 uires Pbx-dependent stratification of unique differentiation states to facilitate both homeotic-like

277 e cancer cell state (stem cell-like state vs differentiation state) to control the cancer stem cell (

278 t some clusters likely represent consecutive differentiation states toward a contractile phenotype, w

279 C) cell line to elucidate the feasibility of differentiation-state transition as a mechanism for ther

280 Overall, we demonstrate that changes in differentiation-state transition rates induced by target

281 Understanding the dynamics of differentiation-state transitions in this context could

282 y, we use modeling to predict the changes in differentiation-state transitions that underlie specific

283 trajectory analysis highlighted intermediate differentiation states underlying SEAM maturation.

284 Depending on their differentiation state, vertebrate neurones can commit su

285 Expression of this aberrant differentiation state was suppressed by GA.

286 In contrast, polyfunctionality and differentiation state were largely maintained between 3

287 visions, but is a function of the CD8 T cell differentiation state, which is genetically controlled i

288 8(+) T cells triggers exhaustion, a distinct differentiation state with diminished effector function.

289 and exhaustion and the association of these differentiation states with clinical outcomes during imm

290 rm cells, exhibit a wide range of histologic differentiation states with varying clinical behaviors.

291 e that CD66(high) cells have an intermediate differentiation state, with a cellular milieu connected

292 sistent with the continuum of activation and differentiation states, with gene expression tending to

293 rectly from activated precursors in multiple differentiation states, with subset heterogeneity maximi