ライフサイエンスコーパス: difficult

1 selective inhibition of endogenous CDK12 is difficult.

2 Z hypothesis from this relationship could be difficult.

3 making the evolution of TSR mechanisms more difficult.

4 ion of genome-wide significant loci has been difficult.

5 ment rendering comparisons across programmes difficult.

6 ory methods between studies made comparisons difficult.

7 l infection in lung parenchyma is relatively difficult.

8 generally make studying their survival more difficult.

9 t differentiating cause from effect has been difficult.

10 and interpreting their relationships can be difficult.

11 owever, cryoET of whole cells is technically difficult.

12 mation rate and high Faradic efficiency (FE) difficult.

13 of their structure and function has remained difficult.

14 als of additional candidates in outbreaks is difficult.

15 on of heterophase noble metal nanostructures difficult.

16 fying those patients who progress to ESKD is difficult.

17 uiring similar evidence in humans has proven difficult.

18 , efficient and flexible manner has remained difficult.

19 tuberculosis is making disease control more difficult.

20 rd immunity through natural infection may be difficult.

21 nt in a rapid and affordable fashion remains difficult.

22 ecision makers perceive their decision to be difficult.

23 offloaded more often when the task was more difficult.

24 ss studies, making comparison across studies difficult.

25 f response functions but makes analysis more difficult.

26 hich makes deciphering biological mechanisms difficult.

27 algorithms makes therapeutic prioritization difficult.

28 ation, incorporation into workflows has been difficult.

29 uvant therapy in the perioperative format is difficult; (4) Major pathologic response rate of 33% is

30 However, the difficult access to their high oxidation states and the

31 ication for tracheal intubation, presence of difficult airway features, more experienced provider lev

32 Identifying sepsis in pediatric patients is difficult and can lead to treatment delay.

33 Conflict commonly occurs in the ICU around difficult and complex decision-making.

34 rrently used, making cross-study comparisons difficult and hindering broad-scale generalizations.

35 nts on facial profile and occlusion is often difficult and lacks long-term stability, it becomes impo

36 long-lasting and late diagnosed infection is difficult and requires cooperation of parasitologists to

37 y of the involved data makes its application difficult and time consuming.

38 ng contrast enhancement make the development difficult, and IONPs suitable for T(1) contrast enhancem

39 atment and/or detection of such pathogens is difficult, and the resulting pathologies are often delet

40 se of K(2) CO(3) , enabled synthesis of more difficult aniline-derived PDIs.

41 of TRIM32 in LGMD2H pathogenesis has proven difficult, as neurogenic phenotypes, independent of LGMD

42 n versus 19.8% in patients without perceived difficult bag-mask ventilation (p < 0.001).

43 The presence of difficult bag-mask ventilation is independently associat

44 Difficult bag-mask ventilation is more commonly reported

45 occurred in 40.2% of patients with reported difficult bag-mask ventilation versus 19.8% in patients

46 Management of ERPC is extremely difficult because available therapeutic regimen cannot e

47 tecture of evolution in the fossil record is difficult because genetic crosses are impossible, the ac

48 elucidating this influence experimentally is difficult because grains typically exhibit a large range

49 ic responses to injury at a systems level is difficult because injury leads to podocyte loss or an in

50 ituted thiophenes bearing reactive groups is difficult because of high reactivity of organometallic r

51 Diagnosis of alveococcosis is difficult because of not typical clinical picture and ir

52 Defining the purpose is difficult, because people seem capable of representing p

53 nal regions in the noncoding human genome is difficult but critical in order to gain understanding of

54 patients with other forms of amyloidosis is difficult but necessary, and tissue typing with adequate

55 nger videos when preparing for infrequent or difficult cases compared with routine cases (P < 0.0001)

56 We also highlight particularly difficult cases of very small transitions between crysta

57 TMD thin-films present uniquely difficult challenges to effective nanoscale crystalline

58 ilizes a glycyl radical cofactor to catalyze difficult chemical reactions in a variety of anaerobic m

59 nths ahead, policy makers are likely to face difficult choices, and the extent of public restraint an

60 important yet frustratingly complicated and difficult class of compounds to analyze, manipulate, and

61 itin-reinforced cell walls render cell lysis difficult, complicating their analysis and identificatio

62 anal systems is one of the most critical and difficult concerns for regenerative endodontics therapy

63 ion of cognitive resources when listening in difficult conditions.

64 ex, chronic illness management and must make difficult decisions about their own health, particularly

65 health care systems have faced or will face difficult decisions about triage, allocation, and reallo

66 mitations in hospital capacity may result in difficult decisions in how life-sustaining technologies

67 bout prognostic factors that can guide these difficult decisions.

68 ed by hepatitis C virus infection is proving difficult, despite the availability of curative drug tre

69 comparison of the degree of interactions is difficult due to different sizes and configurations of p

70 Responding to it has been difficult due to its rapidly changing nature and the sev

71 havior of engineered genetic devices remains difficult due to lack of modularity, wherein a device's

72 rchitectures in living cells, but has proven difficult due to the lack of control over defined topolo

73 ation are therefore increasingly needed, but difficult due to the limitations of JE surveillance.

74 egulation by agonist binding with MD remains difficult due to the timescales necessary to equilibrate

75 res of proteins and their assemblies remains difficult even though the number of solved structures so

76 data which contain numerous trends that are difficult for clinicians to systematically evaluate.

77 early volatile depletion also makes it more difficult for later volcanic outgassing to revive the at

78 lp address the most common cases that remain difficult for text-mining tools.

79 Those tasks are difficult for traditional robots, which predominantly co

80 ulating a truly comprehensive model has been difficult given that the LFP varies dramatically for dif

81 ent of febrile children in these settings is difficult given the lack of diagnostic testing.

82 se delineation of clinical severity is often difficult in children, (129)Xe MRI may be an important b

83 e trivial on linear genomes become much more difficult in genome graphs.

84 relatively easy process, whereas it is more difficult in m-C(2)B(10)H(12).

85 er, the need of WB makes a massive screening difficult in newborns due to economic and technical limi

86 pression of the full-length protein has been difficult, leading to focus on the C-terminal six cystei

87 ments for NVUGIB, particularly for ulcers in difficult locations or those with a rigid and fibrotic b

88 resistant microorganisms are an increasingly difficult management challenge and chemically or photoch

89 ne, and beta-caryophyllene is among the most difficult molecular recognition tasks.

90 activities has always been hampered by their difficult obtention.

91 globulin (beta-lg) present in cheese whey is difficult on SDS-PAGE due to their close proximity durin

92 or numerous applications that are previously difficult or undesirable with fluorescence-based technol

93 hich makes accessing the encased DNA strands difficult, or chemical modification, such as covalent cr

94 mptomatic carotid artery stenosis has proved difficult over the last decade.

95 ermination of SARS-CoV-2 infectivity is very difficult owing to its continuous evolution with over 10

96 f these genetic modifications is crucial but difficult owing to our limited knowledge of how regulato

97 mmatory bowel disease cohorts, referrals for difficult polypectomy, polyp sizes larger than 20 mm, an

98 s used as the terminal reductant, preventing difficult postreaction separations, given the gaseous na

99 o the monomer alphabet turns the notoriously difficult problem of assembling centromeres from reads (

100 which discerning the cause-and-effect can be difficult, PRSs could help to identify the driver biomar

101 nder most political circumstances, this is a difficult question to answer, but the novel coronavirus

102 d to elucidate how nitrogenase achieves this difficult reaction under benign conditions as a means of

103 thesis (SPPS) using several advancements for difficult sequences, native chemical ligation from small

104 nt methods require lengthy reaction times or difficult synthetic strategies.

105 it rate observed here suggests that PrP is a difficult target for small-molecule binders.

106 ce imaging (fMRI) scans of children can be a difficult task, as participants tend to move while being

107 t high speed and subcellular resolution is a difficult task.

108 e embryonic and fetal stages-stages that are difficult to access and investigate in humans.

109 However, supercoil dynamics are difficult to access because of the wide range of relevan

110 tiary amine products, some of which would be difficult to access via currently established methods.

111 ion are located in lymphoid tissues that are difficult to access.

112 ontinually interact and transform, making it difficult to accurately evaluate associated toxicity res

113 e near-infrared spectral region is even more difficult to achieve as further nonradiative pathways co

114 at films into 3D complex structures that are difficult to achieve by conventional fabrication approac

115 ion within the tumor microenvironment but is difficult to achieve due to the high sequence homology a

116 NGs and those good at textiles, it is rather difficult to achieve fiber/fabric-based NGs with both ex

117 cal necessity for radiomics studies is often difficult to achieve in prospective trials.

118 ctively synthesizing nanostructures has been difficult to achieve using conventional capping ligands.

119 throughout the annual cycle, but this can be difficult to achieve when breeding and non-breeding grou

120 Selectivities in such reactions are difficult to analyze because they cannot be determined b

121 ithin dynamic molecular regimes often remain difficult to ascertain.

122 itory and vestibular brain nuclei, making it difficult to ascribe resulting phenotypes solely to the

123 Local tissue inflammation is difficult to assess serially during pathogenesis.

124 spatio-temporal dynamics of sea ice makes it difficult to assess the temporal nature of the changes-e

125 These measurement challenges make it difficult to assess the validity of concerns about diffe

126 The resultant shift is difficult to assess, but overall these changes probably

127 l and mechanistic model development, remains difficult to assess.

128 nd stochastic processes in insular evolution difficult to assess.

129 which, absent gold standards, is inherently difficult to assess.

130 measured, fibrosis and myocyte disarray are difficult to assess.

131 ts of plant cell walls that are particularly difficult to assign by NMR correlation data alone.

132 posure to levels of base editors that can be difficult to attain in hard-to-transfect cells or in viv

133 roughput is required and image artifacts are difficult to avoid.

134 It is difficult to believe that in about 1960 practically noth

135 Adult stomatopods can be difficult to catch due to their inaccessible habitats an

136 o its function, and this behavior has proved difficult to characterize at a structural level due to l

137 ortant role in disease and evolution but are difficult to characterize because their breakpoints map

138 ver, health systems and patients may find it difficult to complete an early postdischarge clinic visi

139 que set of somatic mutations, but it remains difficult to comprehensively genotype an individual cell

140 Thus, it would be extraordinarily difficult to conduct such a trial, and despite the high

141 However, it has proved difficult to constrain the extent of the primary product

142 The shortcoming makes it difficult to constrain the global estimates of oil and g

143 ormation about these changes, although it is difficult to continuously observe changes over many days

144 um, and the key features that render it more difficult to control and eliminate.

145 Yet crystallization is notoriously difficult to control because it is exquisitely sensitive

146 order between layers, but this order can be difficult to control.

147 of reported p63-dependent genes has made it difficult to decipher the p63 gene regulatory network.

148 thways chronically and ubiquitously makes it difficult to define the downstream effects responsible f

149 lem as their reinforced structure makes them difficult to degrade naturally.

150 ltitude of different cell types, it has been difficult to delineate the specific contribution of micr

151 formation dynamics are usually unobserved or difficult to describe.

152 This makes it difficult to design a glycoconjugate that can potently a

153 a-arrestin signaling is not known, making it difficult to design optimum biased ligands.

154 ally occurs later because biliary atresia is difficult to detect during its early stages.

155 cs and scale-dependent processes can make it difficult to detect if there are distinct genetic cluste

156 al sequence of sister chromatids has made it difficult to determine how they topologically interact i

157 After severe brain injury, it can be difficult to determine the state of consciousness of a p

158 tect with fluorescence microscopy, making it difficult to determine whether actin filaments are direc

159 amatic changes in gene expression, but it is difficult to determine which regulated genes are oncogen

160 wever, the exact target of the drug has been difficult to determine.

161 Therefore, it is difficult to develop a mathematical or artificial intell

162 tions makes dietary FB perforation extremely difficult to diagnose, being a laparoscopic or surgical

163 ental factors in disease etiologies makes it difficult to discern the mechanistic links between diffe

164 although the cause-effect relationships are difficult to discern, calling for additional complementa

165 Using traditional methods, it is difficult to disentangle modality-specific activation fr

166 ental and/or social conditions, which can be difficult to disentangle.

167 susceptibility and addiction consequence is difficult to dissociate.

168 Influenza is difficult to distinguish clinically from other acute res

169 ological outcomes, but in such studies it is difficult to distinguish the effects of THC from those o

170 iple species are visually highly similar and difficult to distinguish, it is customary for species de

171 transgenic mouse models of tauopathy make it difficult to draw definitive conclusions about the biolo

172 tion and that these subsets are particularly difficult to eliminate with antibiotics.

173 fined nature of these aggregates has made it difficult to elucidate the structure-property relationsh

174 s pose a global threat and are exceptionally difficult to eradicate after they become abundant in the

175 sociated with implanted medical devices, are difficult to eradicate.

176 go such flexible adaptation has proven to be difficult to establish using simplified models that are

177 in the flavan-3-ol content of food makes it difficult to estimate actual intake without nutritional

178 likely even greater, but remains notoriously difficult to estimate-especially for endemic infections.

179 Rechargeable batteries are notoriously difficult to examine nondestructively, and the obscurity

180 n fossils and because metabolic networks are difficult to experimentally characterize in diverse exta

181 at larger length scales; however, it remains difficult to experimentally image Li-ion diffusion at th

182 ich mitochondrial deficits are prominent and difficult to fix.

183 At failure onset, it may be difficult to forecast the final eruption volume; pressur

184 Fingerprints may be difficult to grasp by visual analysis but could be learn

185 ilding blocks of life, which are fragile and difficult to handle.

186 It has been difficult to identify appropriate targets in nonhematopo

187 These are quite difficult to identify because they originate from the di

188 is such a common feature in fungi that it is difficult to identify species that exhibit widely differ

189 However, it is generally difficult to identify the best aptamer from the resultin

190 uted to protocol differences, although it is difficult to identify the relevant conditions because de

191 dynamics has remained elusive because it is difficult to identify the vocalizing animal among mice i

192 tle) genetic diversity among subjects, it is difficult to identify unique allelic variants, gene modi

193 nous or partial blood flow occlusion that is difficult to identify using existing modalities such as

194 eneracy and low binding affinities make them difficult to identify.

195 that predict risk of financial toxicity are difficult to identify.

196 cteria with their environment, but are often difficult to identify.

197 relation experiments have proven exceedingly difficult to implement on mAbs, and a number of alternat

198 ic systems have been limited as this tool is difficult to implement on the nanoliter or smaller scale

199 wever, the standardized ingestion assays are difficult to implement.

200 vation and monitoring of phenotypes that are difficult to infer from transcriptomics.

201 chemically induced organ damage, but can be difficult to interpret because changes in organ weight m

202 hin PAD populations, data from trials may be difficult to interpret due to differences among the stud

203 Spectroscopic studies on PS II RCs are difficult to interpret due to large spectral congestion,

204 effects by using the hazard ratio, which is difficult to interpret for a positive event, especially

205 Large gene networks can be dense and difficult to interpret in a biologically meaningful way.

206 However, it is difficult to interpret microarray data and identify stru

207 to the flexibility of complex models, it is difficult to intuitively design experiments that will ef

208 This relationship has been difficult to investigate because of the limited availabi

209 erest prior to analysis; however, it remains difficult to isolate and then single-cell sequence such

210 iple risk factors in most cases, it has been difficult to isolate individual effects of the many diff

211 , tumors less than 1 cm in size still remain difficult to localize by conventional means because of t

212 Second, acid-fast MTB bacilli are difficult to lyse.

213 ies outside of polygynous species, making it difficult to make generalized inferences on the role of

214 sufficiency make 22qDS symptoms particularly difficult to manage with traditional therapeutic approac

215 However, it has remained difficult to manipulate neural activity in individual li

216 nfluence photosynthetic rates often makes it difficult to measure or estimate A under dynamic field c

217 lective and the stereoisotopic purity can be difficult to measure(7,8).

218 alt reference electrodes: they are bulky and difficult to miniaturize, leak electrolyte to the medium

219 SBRT) dose is often heterogeneous, making it difficult to model using pixel-level loss.

220 This approach is difficult to multiplex due to spectral overlap between a

221 s, position and orientation fluctuations are difficult to observe with common measurement technologie

222 lated to the scientific question of interest difficult to observe.

223 However, it has proved difficult to obtain cryo-EM reconstructions with suffici

224 between the conformational states, which are difficult to obtain in many situations.

225 in repair and quiescence regulation that are difficult to obtain using rodent models alone.

226 f the magnetic field in the Sun's corona are difficult to obtain.

227 es indicate that normal fused sapphyrins are difficult to oxidize but easier to reduce compared to in

228 pphyrins are relatively easier to reduce but difficult to oxidize.

229 ory evaluation, difference among samples was difficult to perceive.

230 It is difficult to predict how antibodies will behave when mix

231 VF (ventricular tachycardia/fibrillation) is difficult to predict in patients with ischemic cardiomyo

232 here transitions are diffuse, fire spread is difficult to predict, but should become increasingly pre

233 in part because extreme events are rare and difficult to predict.

234 nter weather conditions, but their timing is difficult to predict.

235 and challenging architectures that would be difficult to prepare otherwise.

236 access to molecules that would otherwise be difficult to prepare.

237 gens remain unclear, infectious diseases are difficult to prevent and control.

238 ut, as a noncovalent heterodimer, cumulin is difficult to produce and purify without contaminating GD

239 clinicians to use when circumstances make it difficult to provide ideal bereavement care.

240 ments where growth substrate availability is difficult to quantify can have large downstream impacts

241 ffect both human and natural communities are difficult to quantify.

242 It has been difficult to quantitatively detect such pathological see

243 background nanobarcodes, and yet it has been difficult to rapidly and reliably decode them in an asse

244 A status, especially in populations that are difficult to reach with other strategies.

245 methods, based on autocorrelation, are very difficult to realize due to the lack of mirrors.

246 ermodynamically unfavored processes that are difficult to realize under thermal conditions.

247 ic factors has shown some benefit, but it is difficult to recapitulate the complex set of factors req

248 In equilibrium models, it is difficult to reconcile the reported short transcription

249 aker NDD than rare plants at local scales is difficult to reconcile with the maintenance of overall p

250 radiotherapy for head and neck cancer and is difficult to remedy.

251 However, such reactivity has proven difficult to reproduce in solution with man-made systems

252 sis of this disease heterogeneity has proved difficult to resolve due to poor tumor cellularity and e

253 It is difficult to resolve these patterns using traditional fi

254 ngements with multiple breakpoints are often difficult to resolve, and predicting their effects on ge

255 nections are ubiquitous in the cortex, it is difficult to see how they could deliver the error signal

256 tex (M1) as a model, but in this model it is difficult to separate out the relative contribution of c

257 for the analysis of genomic regions that are difficult to sequence.

258 nts and the presence of an immune system are difficult to simulate in vitro.

259 ble for processing environmental samples are difficult to standardized and most require a long turnar

260 ions of the central nervous system, has been difficult to study due to limited access to functional b

261 ounting for 25% of adult tumors(1), they are difficult to study due to the low disease incidence and

262 s are essential for biology, but they can be difficult to study due to their transient nature.

263 lation states on protein kinase activity are difficult to study experimentally because of challenges

264 Hepatitis B virus (HBV) is an important but difficult to study human pathogen.

265 is correct-known as metacognition-has proven difficult to study in isolation as it usually cooccurs w

266 tion in human cells and tissues, making them difficult to study in traditional animal models.

267 hanges during human corticogenesis have been difficult to study owing to challenges with sample avail

268 nd behavior, many phenotypes of interest are difficult to study with traditional genetic approaches b

269 erstanding of reactions, which are otherwise difficult to study.

270 f cell expression profiles(1-9), it has been difficult to systematically identify and localize all mo

271 ct pharmacologic manner and thus have proven difficult to target in the clinic.

272 great promise for systems that are normally difficult to target with small molecule therapies.

273 its pathophysiology, functional dyspepsia is difficult to treat and, in most patients, the condition

274 Glioblastoma (GB) is a highly aggressive, difficult to treat brain tumour.

275 strategy and address an unmet need for this difficult to treat disease.See related article by Gonda

276 Stenotrophomonas maltophilia is difficult to treat due to the production of multiple int

277 astoma multiforme (GBM) is an aggressive and difficult to treat form of brain cancer.

278 of patients variously designated as having 'difficult to treat', 'treatment-resistant' or 'refractor

279 ools to combat bacterial infections that are difficult to treat, featuring the capacity to evade exis

280 fections in humans are becoming increasingly difficult to treat.

281 cause these properties are correlated, it is difficult to understand each property's unique contribut

282 re not in wide use in bioinformatics and are difficult to use for even technologically sophisticated

283 and precise, but relatively inaccessible and difficult to use.

284 ssue samples, a source that has proven to be difficult to work with image-based spatial analysis tech

285 liver ketone products that contain otherwise difficult-to-access vicinal beta-tertiary and gamma-quat

286 hematopoietic cell transplantation (HCT) for difficult-to-control infections can experience immune re

287 of heparin-induced thrombocytopenia (HIT), a difficult-to-diagnose immune-related complication that o

288 there is the potential to investigate novel difficult-to-drug targets, to apply predictive non-clini

289 genome and are among the most divergent and difficult-to-identify genes using homology-based methods

290 rtup and feedback protocols that necessitate difficult-to-integrate optical and electrical components

291 s are required for low-resource settings and difficult-to-reach populations.

292 in stimulation is able to selectively target difficult-to-reach states, potentially aiding processing

293 Okazaki fragment maturation, replication of 'difficult-to-replicate' DNA regions, end resection, stal

294 s possible to conduct long scan protocols in difficult-to-scan populations and still achieve high-qua

295 st decade to solve structures of notoriously difficult-to-study drug targets at room temperature, has

296 challenges ahead to develop new vaccines for difficult-to-target pathogens, for which we urgently nee

297 We describe such an approach for the difficult-to-target protein alpha-synuclein encoded by t

298 nown binder of KRas, a protein implicated in difficult-to-treat cancers.

299 ent social and environmental goals have been difficult without comparisons across a range of possible

300 anticipation of and performance on easy vs. difficult working memory tasks with emotional stimuli co