ライフサイエンスコーパス: difficulty

1 ined as: no, a little, moderate, and extreme difficulty).

2 nd stress (negative life events and economic difficulties).

3 stic (pattern-based) environments of varying difficulty.

4 sequential order according to their level of difficulty.

5 correlates with transvenous lead extraction difficulty.

6 y with the new system can represent an added difficulty.

7 outcome evaluated was self-reported chewing difficulty.

8 tem using imaging correlates with extraction difficulty.

9 dulate their cerebral activity based on task difficulty.

10 of research aimed at overcoming these three difficulties.

11 p disorder, poor appetite, and concentration difficulties.

12 pirit of professional dedication to overcome difficulties.

13 hat overcomes some of the existing technical difficulties.

14 n characterised by lifelong face recognition difficulties.

15 all employed task conditions and trial level difficulties.

16 rs that are further compounded by processing difficulties.

17 rning curve trough a stepwise fulfillment of difficulties.

18 o might, therefore, be prone to reproductive difficulties.

19 orm complex patterns to tackle environmental difficulties.

20 rted unmet information needs (68%) or social difficulties (66%).

21 nfamiliarity with the healthcare systems and difficulties accessing primary healthcare.

22 Participants reported difficulties adapting to their new life in the UK, inclu

23 P = 0.03, respectively), indicating greater difficulty adapting to changing task demands.

24 aturely because of recruitment and retention difficulties after 243 patients, of a projected 600, had

25 oses, full-time use of wheelchair, dexterity difficulties and also has significantly higher CMT Exami

26 loped language problems such as word-finding difficulties and anomia.

27 Childhood learning difficulties and developmental disorders are common, but

28 ed families presenting with initial learning difficulties and seizures and later psychiatric symptoms

29 This goal has been hampered by technical difficulties and the challenge of obtaining fresh tissue

30 tion-to-surgery intervals increase operative difficulty and complication risk.

31 urgical variables associated with unexpected difficulty and high workload.

32 itory control, highlighting surprise, choice difficulty and value of control as key computations.

33 ific cost estimates and addressing patients' difficulties (and sometimes skepticism) applying trial e

34 d data on ocular comorbidity, intraoperative difficulties, and capsule complications were registered

35 nical population, and demonstrate that these difficulties are also observable in social media behavio

36 Complaints of distress and concentration difficulties are common amongst tinnitus patients in cli

37 If difficulties are encountered during multiproperty optimi

38 An increasing proportion of cognitive difficulties are recognized to have a functional cause,

39 highlight the pervasiveness of interpersonal difficulties associated with BPD features even in the no

40 nal processes underpinning the interpersonal difficulties associated with BPD features, and to inform

41 arning discrete field theories overcomes the difficulties associated with learning continuous theorie

42 Difficulties associated with the current diagnostic tech

43 g goal in drug discovery but hampered by the difficulties associated with the targeting of PPIs, in p

44 study questions, as well as the most common difficulties associated with these approaches that shoul

45 By overcoming these experimental difficulties at least partially, LP-EM has evolved into

46 ficulty may exhibit lower ILA and extraction difficulty based on IVUS imaging.

47 e presence of the unrewarded odorant and had difficulty becoming proficient when MLIs were inhibited

48 etwork architecture across scales due to the difficulties both in segmenting networks from images and

49 status was not associated with birth weight, difficulty breathing, apnea or upper or lower respirator

50 ntestinal signs; history in the past 24 h of difficulty breathing, fast breathing, runny nose, or nas

51 Here, we overcome this difficulty by exogenous delivery of human ACE2 with a re

52 We overcome this difficulty by utilizing indium as a metal flux to synthe

53 dispersal of pathogens like HIV as they have difficulties capturing linkages between infections.

54 e with dementia and/or delirium; people with difficulty communicating, hearing or understanding; peop

55 ned as one's ability to recover quickly from difficulties-contributes to the frail phenotype in patie

56 BCVA <=0.1, and patients with intraoperative difficulties decreased.

57 ficulty performing 6 vision-dependent tasks (difficulty defined as: no, a little, moderate, and extre

58 ve to other facial expressions, indicating a difficulty disinhibiting attention towards painful faces

59 In adjusted models, women had more difficulty distinguishing target stimuli from distractor

60 d death rates using birth-death models faced difficulties due to the restrictive choices of birth and

61 Long-lasting confusion and memory difficulties during the postictal state remain a major u

62 r: 1) preintubation assessment for potential difficulty (e.g., MACOCHA score); 2) preparation and opt

63 s the same age, mouth problems (mouth sores, difficulty eating, dry mouth, bad breath, and/or jaw pai

64 smia, constipation), characteristic movement difficulty (eg, tremor, stiffness, slowness), and psycho

65 nteractions with other people facing similar difficulties enabled relatives to shift perspectives and

66 ent cores provide excellent records, despite difficulties encountered during study runs due to specif

67 n its absence from previous reports owing to difficulties encountered when characterizing this compou

68 innitus themselves, who often report hearing difficulty, especially in noise.

69 he program, such as bureaucratic hassles and difficulties establishing eligibility.

70 However, difficulty expressing human alpha6beta4 receptors in rec

71 a deeper comprehension of the bidirectional difficulties for both ASD and neurotypical individuals i

72 This 'n<<p' property brings difficulties for disease outcome classification using de

73 This situation presents difficulties for experimental studies, drug development,

74 n (HTN) is a world health concern presenting difficulties for its early detection.

75 the corpus of reports studied, which created difficulties for training machine learning systems.

76 The reasons why a given pathogen may present difficulties for vaccine design are unique and tied to t

77 f a modified flanker task regardless of task difficulty for 60 min (p = .001).

78 ad-alignment and filtering strategy that has difficulty handling repeats and homology sequences.

79 rogh's findings and some of the experimental difficulties he faced.

80 Patients often report particular difficulty hearing in busy environments; however, the co

81 esulting in complications such as swallowing difficulty, hepatomegaly and portal hypertension.

82 DNF/TrkB variant carriers exhibited learning difficulties, impaired memory, hyperactivity, stereotype

83 umans on the natural landscape is limited by difficulties in accurately comparing past and present ra

84 Due to difficulties in acquiring enough parasites from the tset

85 However, difficulties in acquiring fine-grained empirical financi

86 an alternative hypothesis is that navigation difficulties in aged people are associated with deficits

87 ers is challenging because of methodological difficulties in analyzing human brains and the confounds

88 y of Escherichia coli AlkB and its homologs, difficulties in assaying their repair activities have li

89 argely ignored until recently, partly due to difficulties in characterizing the chiroptical propertie

90 their 3D structures are reported, has led to difficulties in characterizing the protein-carbohydrate

91 nisms underlying the occurrence of emotional difficulties in children, our findings open avenues for

92 otypic variation, providing insight into the difficulties in choosing the correct combination of targ

93 Difficulties in classifying imaging alterations may resu

94 at conventional neuronal synapses due to the difficulties in collecting such data.

95 al and experimental synthesis studies due to difficulties in comparing the nutrient status across sit

96 many years before malignancies develop, but difficulties in comparing their impact before malignancy

97 ition stated explicitly, which could lead to difficulties in data interpretation and downstream analy

98 ed here include (a) technical and conceptual difficulties in defining a polyploid CM, (b) the candida

99 ide the field of phytopathology, emphasizing difficulties in demonstrating and quantifying this trait

100 Difficulties in EF are transdiagnostic indicators of aty

101 However, ions experience difficulties in entering and leaving such pores, which s

102 This case highlights the difficulties in establishing the true incidence of COVID

103 pplication of CD8(+) T cell immunotherapies: difficulties in identifying tumour-specific peptides pre

104 Given the difficulties in implementing major lifestyle changes or

105 ted for applications in CMOS circuits due to difficulties in integrating complementary n- and p-chann

106 ble to overfitting, poor generalization, and difficulties in interpreting the results.

107 lenges, such as poor recording stability and difficulties in maintaining long-term recording conditio

108 rapid spread of COVID-19 raises significant difficulties in mitigating the epidemic in many countrie

109 rotein design remains challenging because of difficulties in modeling the lipid bilayer.

110 lation, but their study has been hampered by difficulties in monitoring and manipulating them in vivo

111 limited to two or three elements due to the difficulties in morphology control under the harsh alloy

112 However, the development has been impeded by difficulties in N(2) adsorption, protonation of *NN, and

113 AN loss is widely expected to cause hearing difficulties in noise, known as "hidden hearing loss," b

114 Given the difficulties in obtaining demographic data across a spec

115 om one MOF are rare, potentially hampered by difficulties in postsynthetic loading of more than one c

116 all-scale soft robots is challenging, due to difficulties in precise spatiotemporal control of deform

117 s, this complex relationship may explain the difficulties in predicting the adequate insulin dose for

118 desirable goal, but progress is hindered by difficulties in preparing large crystalline metal-organi

119 ough these tools are often unused because of difficulties in processing the data and finding the corr

120 phase formation within the LCP-matrix causes difficulties in protein crystallography experiments in m

121 marked lexico-semantic impairments including difficulties in reading words with exceptional orthograp

122 and epidemiologic surveys facing increasing difficulties in recruiting representative samples of par

123 asing demand for mental health services, and difficulties in recruitment and retention of mental heal

124 f environmental responsiveness can result in difficulties in reproducing studies from the same instit

125 poor sensitivity of existing techniques and difficulties in resolving very small heat outputs.

126 mics because of a lack of reference spectra, difficulties in sample preparation, and an absence of tw

127 o provide a validated approach to overcoming difficulties in sequencing Y chromosome in other mammali

128 th currently available drugs poses treatment difficulties in some patients due to drug resistance or

129 H-labelling is not straightforward, owing to difficulties in supplying a suitably isotopically-labell

130 Its study has been thwarted by difficulties in the accurate measurement of cell size an

131 new insights into a potential role of sleep difficulties in the development of ASD.

132 patients with PKD can be challenging due to difficulties in the diagnostic evaluation and the hetero

133 For 1As this overcomes prior difficulties in the synthesis of this classical arsonium

134 neal epithelial stem cell niche, but, due to difficulties in their isolation and cultivation, their b

135 istant bacteria and to overcome the inherent difficulties in treating biofilm-associated infections.

136 hods have constantly evolved, which leads to difficulties in using data generated with older methodol

137 documented in plants due in large measure to difficulties in working with plant systems.

138 ate Wnt-FZD interactions are hampered by the difficulties in working with Wnt proteins and their reca

139 ed for 21%-28% of all cases, underlining the difficulty in accurately ascertaining the causes of fata

140 response and wireless operation, despite the difficulty in achieving localized actuation because of t

141 RD analysis showed that in 2015, the chewing difficulty in aged above 65 was 2.2% lower than in those

142 nthesis and chemical stability, it still has difficulty in applying to highly sensitive (i.e. parts-p

143 nty in classification primarily derived from difficulty in ascertaining peripheral distribution, mult

144 iltration efficiency improvements limited by difficulty in breathing, and no safe reusability), which

145 The difficulty in combining high fidelity with fast operatio

146 osurfaces remains a challenge because of the difficulty in component tuning, morphology control, and

147 allenges to their widespread adoption is the difficulty in control and optimization of the accelerato

148 e large size of antibodies and corresponding difficulty in crossing the blood-brain barrier has limit

149 Despite the difficulty in culturing many microbes from an environmen

150 res involving bone grafts creates additional difficulty in decision making for practitioners.

151 in of H-bonds that impart stability, causing difficulty in digestion for bottom-up measurements.

152 and ponderal growth has been hampered by the difficulty in directly sampling the small intestinal muc

153 ape behavior, however, is unknown due to the difficulty in discerning which mouse in a group is vocal

154 em and clinical management is complicated by difficulty in discriminating between latent infection an

155 to 0.3%; P = 0.14), but there is substantial difficulty in disentangling the unique associations with

156 ver variability in this procedure as well as difficulty in distinguishing tumor from non-tumor cells

157 ing in perovskite solar cells because of the difficulty in doping perovskites in a controllable way.

158 The difficulty in expressing NifEN, a complex, heteromultime

159 etal nitrides remains challenging due to the difficulty in fabricating stoichiometric and high-qualit

160 A key mechanism underlying Allee effects is difficulty in finding mates at low densities.

161 etation of epigenome data, compounded by the difficulty in generating reliable single-cell DNA methyl

162 The major obstacle to its application is the difficulty in growing a single-crystal epitaxial film of

163 Given the cost and difficulty in handling wooden barrels, and as an alterna

164 materials are not clear, in part due to the difficulty in identification during electrocatalysis.

165 in clinical testing, in part because of the difficulty in identifying molecules that reduce tau incl

166 a large knowledge gap of others owing to the difficulty in identifying them because of the typically

167 which are known to be challenging due to the difficulty in initial nucleation.

168 f a single structure that not only increases difficulty in isomer separation but can also introduce t

169 This complexity, combined with difficulty in measuring transcript abundance and high se

170 r use of flexible bronchoscopy have included difficulty in navigating to the lung periphery, the avoi

171 ventional source imaging techniques, namely, difficulty in objectively estimating the spatial extent,

172 Specific problems include the difficulty in obtaining high Mn contents, considerable b

173 onstrate the power of CSP to rationalize the difficulty in obtaining polymorphs of the well-known pha

174 has not been well researched because of the difficulty in obtaining single-phase clusters and the la

175 gged behind other areas primarily due to the difficulty in obtaining some of the unique characteristi

176 ed similarly, although with slightly greater difficulty in patients with ALS-FTD on category fluency

177 c hazardous reagents and are associated with difficulty in purification of the by-products.

178 This is mainly due to the difficulty in quantitatively analyzing the intermixed ph

179 tern of behavior potentially indicative of a difficulty in relying on learned contingencies, with no

180 e, less surgeon control over procedures, and difficulty in scheduling cases.

181 erties of bulk crystals, and also due to the difficulty in separating (sub)micrometer-scale chiral cr

182 ains a relevant challenge, due mainly to the difficulty in spatially locating the surroundings of par

183 ocalize by conventional means because of the difficulty in specific targeting/delivery to the tumor s

184 A major difficulty in studies of the brain, from the molecular t

185 In this work, we relate the difficulty in the deboronation of the carboranes with th

186 ed, owing to two critical challenges: 1) the difficulty in the development of homogeneous single-phas

187 or peptides that can be fused to FPs and the difficulty in transforming the binding of metal ions int

188 Resistance to chemotherapy is a major difficulty in treating the disease.

189 animal models and "tinnitus inducing hearing difficulty" in human subjects.

190 eoselective drugs can ameliorate therapeutic difficulties including adverse toxicity and poor pharmac

191 and optimization of the patient and team for difficulty-including using a checklist, acquiring necess

192 llenging to fit in well-defined manner, have difficulties incorporating binding data, and cannot be r

193 We avoid the difficulties inherent in measuring the long time behavio

194 2, fully adjusted, reference: PSQI <= 5) and difficulties initiating sleep (almost nightly versus nev

195 -resistant epilepsy, cerebral palsy, feeding difficulties, intellectual disability and other neurolog

196 zation in humans is still unknown due to the difficulties involved studying the human brain via elect

197 m for older adults, leading to communication difficulties, isolation, and cognitive decline.

198 Surgeons reported difficulty levels higher than expected for 22% of proced

199 of natural red colorants but currently face difficulties matching the hue range, stability, and affo

200 al factors associated with higher extraction difficulty may exhibit lower ILA and extraction difficul

201 referrals, limited access to healthy foods, difficulties meetings preoperative requirements, and lac

202 arking and interpreting them is fraught with difficulties (need to compare them on a common input dat

203 ve impairment (MCI) for those with cognitive difficulties not impairing enough to qualify as dementia

204 wever, an important limitation of TTE is the difficulty obtaining interpretable images due to externa

205 mpared to model organisms, and the technical difficulties of metagenome assembly and phasing in heter

206 Because of the difficulties of normalizing body fat content in patients

207 (eg, the necessity, costs, and supply chain difficulties of refrigerant gas; equipment failure; and

208 rennial trees, especially with the intrinsic difficulties of successful propagation, material exchang

209 a vaccine antigens, and discuss the inherent difficulties of updating influenza vaccine strains each

210 ink may be overestimated globally due to the difficulty of accounting for all C losses across heterog

211 r limitation of multivariate analysis is the difficulty of aligning features across brains, which mak

212 -toxin action remains elusive because of the difficulty of capturing the functionally relevant form o

213 udge commuting behaviour highlights both the difficulty of changing commuter behaviour and the import

214 hing circular RNAs from other lncRNAs due to difficulty of classification.

215 ink between structural surface roughness and difficulty of crystallisation.

216 ultiple positions dramatically increases the difficulty of designing a DC library and leads to the cr

217 poorly quantified, primarily because of the difficulty of determining photobleaching apparent quantu

218 naling molecule, has been limited due to the difficulty of developing stable pro-drugs with slow kine

219 Owing to the inherent difficulty of empirical field studies, ecological state

220 rlying theoretical complexity as well as the difficulty of engineering multicellular networks biochem

221 bgenomic contexts, which given the technical difficulty of experimentally separating cellular mixture

222 pplication of antibody therapies lies in the difficulty of generating nonimmunogenic antibodies in la

223 The findings illustrate the difficulty of identifying a decision-maker's strategy an

224 otentially provide insight into the relative difficulty of identifying different radiology findings.

225 ever, progress has been hindered both by the difficulty of identifying individuals who will eventuall

226 ere reported to lack BST-2, highlighting the difficulty of identifying sequences of this extremely va

227 ertebrates is rare, primarily because of the difficulty of identifying such behaviors with confidence

228 ocesses are still elusive due in part to the difficulty of imaging trace metals together with protein

229 e from 2-diazo-1,3-indandione because of the difficulty of inducing the initial rearrangement.

230 he biology of regulatory elements due to the difficulty of interpreting the complex features they lea

231 use is poorly understood, largely due to the difficulty of mapping waterpoints used by khulan through

232 The study identifies the difficulty of metal release from hTF as potentially rela

233 ns in cellular homeostasis is limited by the difficulty of monitoring their activity in vivo.

234 man translational studies are limited by the difficulty of obtaining cells taken directly from their

235 ms expressed from common genes, and (ii) the difficulty of obtaining full-length transcript sequences

236 Nevertheless, given the difficulty of predicting extinctions, null models provid

237 in part due to the lack of relevant data and difficulty of predicting the location of catastrophic dr

238 ion methodology is currently hampered by the difficulty of removing the directing group.

239 current immunotherapies, due in part to the difficulty of reprogramming the highly immunosuppressive

240 Further, because of the difficulty of studying pregnant patients, high-quality r

241 e reasons for that is the relative technical difficulty of the generation of well-defined gradients o

242 asions remains incomplete, partly due to the difficulty of tracking and studying behavioural interact

243 professionals were less satisfied due to the difficulty of treating the images and lack of familiarit

244 sessing the severity of MR and emphasize the difficulty of using an integrated approach that incorpor

245 assign more patients to an inferior arm, (4) difficulty of validly analyzing results, and (5) the pot

246 To overcome the difficulty of writing media with a large coercivity, hea

247 ompared to those reporting no vision-related difficulty on any task.

248 formance during cases with unexpectedly high difficulty (P < 0.001).

249 prone provides an avenue for unraveling the difficulties people with obesity face when they try to l

250 ninfected (HIV-) MSM controls reported their difficulty performing 6 vision-dependent tasks (difficul

251 re more likely to report moderate or extreme difficulty performing at least 1 task (21% for HIV+ comp

252 articipants reporting extreme vision-related difficulty performing at least 1 task had 11.2 times the

253 Despite these difficulties, personal strengths, including improved sch

254 d utilize this example to highlight both the difficulties pertaining to the identification of local a

255 alth outcome measures were the Strengths and Difficulties Questionnaire (children/adolescents) and 6-

256 hopathology symptoms using the Strengths and Difficulties Questionnaire in grade 7 (ages 12-13) and g

257 Both ML classifiers and radiologists had difficulty recognizing the chest radiographs' manufactur

258 strategy deficits in ageing can result from difficulties related to landmark coding, and predict rec

259 ug delivery to the kidneys faces significant difficulties resulting in treatment failure in several r

260 Due to worldwide nursing shortages and difficulty retaining staff, long shifts for nursing staf

261 entage of patients with high lead extraction difficulty score had low IVUS grade, and the degree of t

262 nts with low IVUS grades and lead extraction difficulty scores.

263 n = 1), mouth irritation (n = 4 and n = 0), difficulty sleeping (n = 3 and n = 2), and vivid dreams

264 ntaged and typically suffer from educational difficulties, social deprivation, socio-economic dysfunc

265 delay, autistic features, hypotonia, feeding difficulties, spasticity or ataxic gait, and abnormal br

266 These difficulties stem from the use of new programming langua

267 e outcomes and continuity of care and social difficulties suggest these may be meaningful variables t

268 Additional difficulties surrounding low weight metabolite visualiza

269 oach reported here effectively overcomes the difficulties that are commonly encountered with reshapin

270 t other institutions mitigate the inevitable difficulties that arise when academic hospitals close.

271 ty disorders is cognitive control, given the difficulty that young patients experience in dismissing

272 de self-care management strategies for sleep difficulties to ensure retention at work.

273 However, the inherent difficulty to accurately model systems in aqueous soluti

274 has low reliability for detecting MI and is difficulty to apply to limb 6-lead ECG based life type o

275 heir clinical application is hampered by the difficulty to deliver them into cancer cells and suscept

276 y (99% correct classification), but had more difficulty to discriminate Chetoui and Oueslati samples

277 nging due to their high insolubility and the difficulty to ionize them.

278 ion due to the optical diffraction limit and difficulty to preserve a high-quality wave front for foc

279 er purification due to its high toxicity and difficulty to remove at ultra-dilute concentrations.

280 ng type of motor impulsivity, defined as the difficulty to withhold a specific action, shares some co

281 Many tinnitus patients report difficulties understanding speech in noise or competing

282 ce a novel modeling framework to tackle this difficulty using impulsive differential equations.

283 Degree of extraction difficulty was assessed using 2 metrics and correlated w

284 Greater social difficulty was consistently associated with poorer quali

285 nd the degree of transvenous lead extraction difficulty was similar to patients with low IVUS grades

286 To address these analytical difficulties, we developed a novel template-matching-bas

287 In order to overcome these difficulties, we present here a sophisticated inverted R

288 To overcome these difficulties, we propose DR-A (Dimensionality Reduction

289 examined separately, whereby increased sleep difficulties were associated with more depressive sympto

290 ple tend not to disclose sexual concerns and difficulties which increases the risks for sexually tran

291 Because of logistical difficulties with cryotherapy (eg, the necessity, costs,

292 etails are only partly understood because of difficulties with experimentally accessing the relevant

293 evices available that help overcome anatomic difficulties with laryngoscopy and provide rescue oxygen

294 hearing loss manifests as speech perception difficulties with normal hearing thresholds.

295 to develop LFM on porous surfaces due to the difficulties with selective binding of the developing ag

296 acute dysexecutive syndrome characterized by difficulty with attention, concentration, and processing

297 The high complication rates stem from difficulty with laryngoscopy and tube placement, consequ

298 antine reported less fatigue (P = .04), less difficulty with remembering things (P = .01), and less d

299 with remembering things (P = .01), and less difficulty with speaking (P = .049) and using imputed da

300 However, due to the difficulties working in high-elevation mountain systems,