ライフサイエンスコーパス: difficulty in *ing

1 g with a higher frequency of eye redness and difficulty in swallowing.

2 mmation, epithelial barrier dysfunction, and difficulty in swallowing.

3 A difficulty in developing 5-HT2C agonists is that most li

4 , the extent of genomic instability, and the difficulty in acquiring a large sample size in a rare tu

5 ive weakness of the human MOC reflex and the difficulty in demonstrating a robust functional role in

6 n the rate of appropriate use highlights the difficulty in developing a standardized definition that

7 ce of context-dependencies has underscored a difficulty in establishing a systematic analysis about t

8 Given the difficulty in finding a cure for HIV/AIDS, a promising p

9 or treating periodontitis effectively is the difficulty in finding a target that can inhibit bone los

10 The major obstacle to its application is the difficulty in growing a single-crystal epitaxial film of

11 eptide (MIP), fall asleep normally, but have difficulty in maintaining a sleep-like state.

12 or limitation of the sensor, however, is its difficulty in measuring a broad concentration range of t

13 Parkinson's disease (PD) patients have difficulty in performing a dual-task.

14 ive role to re-challenge, it illustrates the difficulty in producing a vaccine in a young, immunologi

15 Difficulty in being able to use this information to opti

16 conventional introns, however, also portends difficulty in generating accurate gene models and highli

17 The difficulty in generating accurate maps of LCR22s has als

18 ent to tuberculosis control in Africa is the difficulty in diagnosing active tuberculosis (TB), parti

19 evelopment of heterogeneous catalysts is the difficulty in identifying active sites.

20 higher scores indicates more ability or less difficulty in performing activities), and comparison of

21 higher scores indicates more ability or less difficulty in performing activities), and comparison of

22 Many genetic manipulations are limited by difficulty in obtaining adequate levels of protein expre

23 Difficulty in obtaining air pollutant emission permits a

24 graduates from 2008 to 2012 report increased difficulty in identifying an HPB-focused practice versus

25 Patients with salivary hypofunction exhibit difficulty in chewing and swallowing foods, tooth decay,

26 of proteins, yet researchers have faced much difficulty in expressing and purifying the full-length v

27 This poorer response may reflect patients' difficulty in forming and maintaining attachments, inclu

28 Parkinson's disease and focal dystonia have difficulty in generating and preventing movement.

29 This specific difficulty in identifying and distinguishing the feeling

30 The difficulty in isolating and propagating functional prima

31 The difficulty in organizing and mining this unprecedented a

32 resolution limit of light microscopy and the difficulty in preserving and analyzing ultrastructure wi

33 ients reported higher levels of alexithymia (difficulty in recognizing and expressing emotions) compa

34 recently had become painful and was causing difficulty in speaking and swallowing.

35 ajor obstacle in the quest for a cure is the difficulty in targeting and measuring latently infected

36 course of targeting mitochondria due to the difficulty in tracking and quantifying small molecules i

37 In Experiment 1, participants had greater difficulty in withholding and produced more accurate and

38 iltration efficiency improvements limited by difficulty in breathing, and no safe reusability), which

39 ific antioxidant target(s), and the inherent difficulty in delivering antioxidants where they are nee

40 nd fetal safety, ethical considerations, the difficulty in designing appropriate trials to assess the

41 application and approval dates, and level of difficulty in obtaining approval.

42 e, numerous factors related to the intrinsic difficulty in performing AR research, and economic force

43 Difficulty in differentiating between tissue types commo

44 In males, variances were small and there was difficulty in discriminating between additive maternal a

45 em and clinical management is complicated by difficulty in discriminating between latent infection an

46 Difficulty in distinguishing between effects of ongoing

47 Older adults' difficulty in distinguishing between old and new informa

48 MSD analysis has several pitfalls, including difficulty in selecting between competing methods of mot

49 But there exists much difficulty in using BMSCs as a clinical therapy.

50 vivo has not been elucidated because of the difficulty in monitoring brain Abeta oligomers in living

51 bubble size distributions is limited by the difficulty in measuring bubble sizes over wide spatial o

52 e dimensions are stable, thus overcoming the difficulty in exploring by experiment or simulation the

53 chieving climate goals can be complicated by difficulty in quantifying C inputs (i.e., differentiatin

54 A major difficulty in implementing carbon-based electrode arrays

55 e, less surgeon control over procedures, and difficulty in scheduling cases.

56 nsity for precipitation, mainly owing to the difficulty in establishing causality.

57 Due to the difficulty in conducting clinical trials for vaccines an

58 nt for spinal cord injury is hindered by the difficulty in conducting clinical trials, which to date

59 ong patients with Alzheimer disease leads to difficulty in providing clinical counseling and diminish

60 ave, to date, been unsuccessful owing to the difficulty in preparing cold, gas-phase C(60) in suffici

61 This difficulty in separating colorectal cancer from these ot

62 contributing factor to irreproducibility is difficulty in interpreting complex experimental methodol

63 A major difficulty in applying computational design methods to n

64 terostructures is challenging because of the difficulty in achieving controllable direct synthesis or

65 early defined in larval zebrafish due to the difficulty in defining cytoarchitectonic nuclear boundar

66 distributions, researchers have experienced difficulty in integrating data across platforms.

67 The difficulty in developing depot formulations stems in lar

68 have received much less attention given the difficulty in assessing detailed molecular-level informa

69 One difficulty in measuring dicarboxylic acid emissions is t

70 g of such processes has been hindered by the difficulty in producing diffraction-quality crystals of

71 They also highlight the difficulty in disentangling direct checkpoint pathways f

72 However, experimental methods have difficulty in solving disordered PPIs and existing prote

73 Due to the difficulty in recognizing distant-homology templates, ho

74 The difficulty in treating drug addiction is compounded by t

75 (MD worse than -12 dB) loss, but had greater difficulty in detecting early (MD better than -6 dB) los

76 y the scarcity of available material and the difficulty in distinguishing early hematophages from non

77 dynamic nature of the oceans and continuing difficulty in managing ecosystem impacts of fisheries, i

78 e-negatives, rapid drug clearance rates, and difficulty in obtaining enough specimen for testing.

79 Given the perceived difficulty in modifying extracellular matrix proteins to

80 The inherent difficulty in eliciting facial control over carbocations

81 In cases of difficulty in locating fingerprints, additional powders

82 Reading disability is a brain-based difficulty in acquiring fluent reading skills that affec

83 They also highlight the difficulty in using fMRI data for arbitrating between di

84 While a fundamental difficulty in planning for the next pandemic remains the

85 amily members with Alzheimer disease and the difficulty in slowing functional decline.

86 w-listed barriers to an academic career were difficulty in obtaining funding and lower compensation.

87 This gap can be attributed to the difficulty in establishing general rules to encompass th

88 cantly underdeveloped, partly because of the difficulty in applying genetics and common molecular app

89 ch is slow, in part because of the cognitive difficulty in interpreting graphs.

90 ming from the lack of validation methods and difficulty in studying heterogenous diseases of aging.

91 The difficulty in combining high fidelity with fast operatio

92 Specific problems include the difficulty in obtaining high Mn contents, considerable b

93 single precious atom species has arisen from difficulty in synthesizing homogeneous and stable single

94 re Gram-negative vesicles originate, and the difficulty in envisioning how such a process could occur

95 This is primarily due to the difficulty in monitoring how the mosquito olfactory syst

96 ystems for some important viruses and by the difficulty in conducting human clinical trials for disea

97 g of norovirus biology is limited due to the difficulty in growing human norovirus in vitro and a lac

98 This uncertainty emanates from the difficulty in measuring in situ soil N2 production and f

99 led remain unresolved because of the extreme difficulty in obtaining in vivo measurements.

100 l size remain poorly understood owing to the difficulty in sizing individual bacteria over long perio

101 The difficulty in distinguishing infection by Zika virus (ZI

102 cification of a number of parameters and has difficulty in extracting information on compounds that a

103 ther than research trials, patients may have difficulty in getting insurance coverage for genetic tes

104 for halide-adsorbed nanocrystals due to the difficulty in analysing interactions between metals and

105 tween these components is limited due to the difficulty in assaying interactions in the context of th

106 is challenging in oligomeric proteins is the difficulty in characterizing intermediate, singly bound

107 ads to underestimation of disease burden and difficulty in measuring interventions to control CDI.

108 inhibitory control by the prefrontal cortex, difficulty in controlling intrusive thoughts is also ass

109 CR repertoires is problematic because of the difficulty in performing investigations in vivo.

110 mpound identification due to matrix effects, difficulty in separating isomer and isobaric ions, and l

111 ane-encoding exon 3 has been hindered by the difficulty in distinguishing it from the transmembrane i

112 been hampered by its slow growth in culture, difficulty in isolating it, and lack of commercial molec

113 s very important, yet there is a fundamental difficulty in understanding its mechanism: to measure an

114 Much of the inconsistency stems from the difficulty in conducting large, well-controlled OF studi

115 However, the difficulty in transferring large-scale data to clients a

116 loping and optimizing these therapies is the difficulty in determining levels of GCase activity prese

117 ion efficiency, lack of reproducibility, and difficulty in providing linear quantification.

118 eling following receipt of test results, and difficulty in providing linkage to care.

119 response and wireless operation, despite the difficulty in achieving localized actuation because of t

120 One difficulty in performing long-term FT-IR measurements on

121 The difficulty in accessing lung tissue and washes from indi

122 clinic; however, [(18)F]FDG-PET often faces difficulty in differentiating malignant tissues from cer

123 The difficulty in accessing mammalian nephrons in vivo hinde

124 Despite the difficulty in culturing many microbes from an environmen

125 maging is underused, in part, because of the difficulty in interpreting maps without an underlying ce

126 t abundant microbial cells in the ocean, but difficulty in cultivating marine Thaumarchaeota has hind

127 of undefined blood group antigens, may cause difficulty in finding matching blood.

128 A key mechanism underlying Allee effects is difficulty in finding mates at low densities.

129 occur at the BCV membrane is limited by the difficulty in purifying membrane fractions from infected

130 One difficulty in studying metastasis stems from the complex

131 Given our vast methane reserves and the difficulty in transporting methane without substantial l

132 nt of such gastroresident electronics is the difficulty in powering millimeter-sized electronics devi

133 This is a result of the difficulty in extracting molecular information from in v

134 in clinical testing, in part because of the difficulty in identifying molecules that reduce tau incl

135 The difficulty in treating mood disorders has brought about

136 deling these biases has been hindered by the difficulty in identifying mutated Ig sequences in vivo i

137 Much of the difficulty in assessing myeloid cell-specific functions

138 mentary mode has been challenging due to the difficulty in making n-type carbon nanotube transistors

139 tions have been limited by the extraordinary difficulty in obtaining n-type conductivity.

140 e not fully understood, partially due to the difficulty in obtaining native-like folded proteins in v

141 s a challenge given its slow progression and difficulty in obtaining nerve samples.

142 r is still speculative, owing to the extreme difficulty in recreating neutral matter-antimatter plasm

143 The difficulty in expressing NifEN, a complex, heteromultime

144 ies exist in these young children due to the difficulty in obtaining objective evidence of reversible

145 e to their low ionization efficiency and the difficulty in separating oligosaccharides because of the

146 tern of behavior potentially indicative of a difficulty in relying on learned contingencies, with no

147 ure of proteome quality is likely due to the difficulty in producing one, a problem that we have appr

148 but this could not be tested because of the difficulty in extracting only the cell-wall lipids.

149 Part of the difficulty in developing optimal therapies is the large

150 ironments remains challenging because of the difficulty in achieving optimized oxygen binding strengt

151 Dyspnea, difficulty in walking or climbing, fatigue/increased nee

152 ilding blocks remains a challenge due to the difficulty in preparing organic structural units of prec

153 d their potential benefits in overcoming the difficulty in transitioning PDT into the medical field.

154 f semantic representations is complicated by difficulty in disentangling perceptual and semantic infl

155 However, the difficulty in obtaining periodic crystal lattices which

156 nty in classification primarily derived from difficulty in ascertaining peripheral distribution, mult

157 ing in perovskite solar cells because of the difficulty in doping perovskites in a controllable way.

158 as proved challenging, partly because of the difficulty in differentiating phenotypes that define hom

159 ing question in part because of the inherent difficulty in quantifying plutonic volumes.

160 However, the difficulty in attaining PMA in ultrathin CoFeB layers ha

161 onstrate the power of CSP to rationalize the difficulty in obtaining polymorphs of the well-known pha

162 However, past research evidences difficulty in disaggregating prenatal environmental infl

163 us protein complexes has been limited by the difficulty in obtaining pristine cell-derived assemblies

164 nging because of the malignant potential and difficulty in predicting prognosis.

165 e anticipated to be more challenging, due to difficulty in isolating proposed intermediates as a resu

166 This outcome highlights the difficulty in targeting Prph2-associated gain-of-functio

167 terns during meiosis remain undefined due to difficulty in obtaining pure germ cell samples, especial

168 d proteoforms were not identified due to the difficulty in obtaining quality tandem mass spectrometry

169 The difficulty in detecting rare infected cells immediately

170 ny metal-oxide hosts, largely because of the difficulty in establishing reaction kinetics that favors

171 ng of many adult epithelia is limited by the difficulty in maintaining relevant stem cell populations

172 etation of epigenome data, compounded by the difficulty in generating reliable single-cell DNA methyl

173 ed symbiotic or parasitic lifestyle, but the difficulty in culturing representative members constrain

174 plexity of the cholinergic circuitry and the difficulty in comparing results from in vivo studies obt

175 fies immunogenicity, they also emphasise the difficulty in generalising results from rodents into pri

176 nts on provider time to collect data and the difficulty in accessing risk calculators.

177 ered for integrated photonics because of the difficulty in coupling selectively to high-order modes,

178 rhythms in most human tissues is hampered by difficulty in collecting serial samples.

179 ination in T cells, can create a fundamental difficulty in determining single-cell kinetics from cell

180 has not been well researched because of the difficulty in obtaining single-phase clusters and the la

181 king-related behaviors, among them a greater difficulty in quitting smoking.

182 recise roles are often unresolved due to the difficulty in capturing "snapshots" during the export pa

183 gged behind other areas primarily due to the difficulty in obtaining some of the unique characteristi

184 er of the two patient groups had any special difficulty in producing spatial details.

185 nd silylpropylcarbamate), largely due to the difficulty in obtaining spectroscopic identification for

186 th cochlear implants, often experience great difficulty in understanding speech in noisy environments

187 gh-order stimulus representation rather than difficulty in sustaining stable activity patterns over t

188 rent poor photoreactivity of enzymes and the difficulty in achieving stereochemical control of the re

189 etal nitrides remains challenging due to the difficulty in fabricating stoichiometric and high-qualit

190 mplicate that subjects with PTSD experienced difficulty in overcoming Stroop interference.

191 ems, however, remains challenging due to the difficulty in creating structurally controlled macromole

192 till poorly understood, in part owing to the difficulty in characterizing structure at the nanoscale,

193 erties of bulk crystals, and also due to the difficulty in separating (sub)micrometer-scale chiral cr

194 The results highlight the difficulty in applying such models to realistic media un

195 The main difficulty in performing such simulations is enumerating

196 The study demonstrates the difficulty in using such structures to infer a mechanism

197 bstacles to the use of (225)Ac have been the difficulty in finding suitable chelators to stably attac

198 le to the perovskite CQD system owing to the difficulty in modulating surface ligands and structural

199 due to the scarcity of clinical isolates and difficulty in performing susceptibility tests to determi

200 of the zebrafish is currently limited by the difficulty in obtaining systematic electrophysiological

201 A fundamental difficulty in testing "targeted therapies" in acute myel

202 our study region, which highlights potential difficulty in detecting temporal responses of organism a

203 ion, by the scarcity of material, and by the difficulty in visualizing that material.

204 Studies of PSC are limited due to difficulty in accessing the cholangiocyte, the small per

205 itations due to the narrow dynamic range and difficulty in adapting the method for multi-point sensin

206 One of the key challenges is the difficulty in assessing the magnitude of the maximum pos

207 of methyl NMR has often been limited by the difficulty in assigning the methyl resonances.

208 plasm exist but are underutilized due to the difficulty in capturing the dynamic nature of physiologi

209 with promising anticancer activity, but the difficulty in characterizing the mechanism of action of

210 This finding highlights the difficulty in characterizing the structure-activity rela

211 and therefore mostly counterfeit, due to the difficulty in checking the geographic provenance of oliv

212 remely challenging, in large part due to the difficulty in crossing the blood-brain barrier (BBB).

213 e large size of antibodies and corresponding difficulty in crossing the blood-brain barrier has limit

214 herin function in mESCs is compounded by the difficulty in delineating the structural and signalling

215 n studying these binary oxide systems is the difficulty in describing the heterogeneities that occur

216 rbon (CHC) blends of insects, as well as the difficulty in determining the absolute configurations of

217 gress in the field has been inhibited by the difficulty in determining the energy levels of molecules

218 to 0.3%; P = 0.14), but there is substantial difficulty in disentangling the unique associations with

219 and is currently incurable due, in part, to difficulty in eliminating the leukemia cells protected b

220 complex nature of cellular processes and the difficulty in establishing the identity of individual me

221 iques is problematic, owing to the practical difficulty in establishing the initial conditions.

222 e brain-cognition mappings--for example, the difficulty in establishing the specificity of postulated

223 Pereira points out the difficulty in establishing the strength of the associati

224 sion are not treated, perhaps because of the difficulty in explaining the benefits and risks of r-tPA

225 ouble predicting this history because of the difficulty in following the feedback of energy from stel

226 However, the difficulty in forming the unstable diazo compound partne

227 nsively studied at the tissue level, but the difficulty in imaging the endothelium with cellular reso

228 The main difficulty in improving the efficiency of PV energy conv

229 tation of replacement photoreceptors, is the difficulty in inducing the grafted cells to grow and mai

230 daughter cells is unknown, partly due to the difficulty in interpreting the complex dynamic behavior

231 he inclusion of studies of variable quality; difficulty in isolating the effects of specific social n

232 aviourally, participants experienced greater difficulty in judging the concreteness of multi-meaning

233 comparative epidemiological studies, and the difficulty in keeping the review up to date with the pac

234 ng effect of age - children had much greater difficulty in learning the task compared to adults, with

235 The difficulty in maintaining the reconstituting capabilitie

236 surface ligands are currently limited by the difficulty in manipulating the surface density of ligand

237 r distortions due to the Kerr effect and the difficulty in modulating the optical field to effectivel

238 s indicated on a 5-point scale the degree of difficulty in performing the following procedures: lesio

239 (i.e., number of free associates produced or difficulty in performing the free associate task).

240 ause of the following: dystonia resulting in difficulty in placing the patients in frame, patient's i

241 The main difficulty in quantifying the spatial pattern of disease

242 l-carbon quaternary stereogenic center), the difficulty in reaching the desired adducts through asymm

243 c suppressors of this mutant suggests it has difficulty in releasing the N-terminal membrane targetin

244 Difficulty in resolving the photoreceptors in the umbo,

245 f SAXS profiles is nontrivial because of the difficulty in separating the scattering signals of each

246 rdinate motifs are extremely rare due to the difficulty in stabilizing the planar hypercoordinate con

247 do not generate ionic current, resulting in difficulty in studying the function and trafficking of t

248 or peptides that can be fused to FPs and the difficulty in transforming the binding of metal ions int

249 Resistance to chemotherapy is a major difficulty in treating the disease.

250 ith specific properties is often hindered by difficulty in tuning the material composition without sa

251 The difficulty in understanding the emergence of this large-

252 Persistent difficulty in using the upper limb remains a major contr

253 ambiguous interactions with supports, posing difficulty in maximizing their catalytic performance.

254 e had a redshift measurement, because of the difficulty in pinpointing their celestial coordinates.

255 igning peptide-based catalysts, but also the difficulty in predicting their accessible transition sta

256 iet were more likely to experience low or no difficulty in providing their patients with dietary advi

257 not been well documented due to the inherent difficulty in separating their effects.

258 ast lignocellulosic biomass reserves and the difficulty in bioprocessing them without expensive pretr

259 a large knowledge gap of others owing to the difficulty in identifying them because of the typically

260 However, so does the difficulty in identifying them.

261 AD per unit of (131)I activity elucidate the difficulty in achieving therapeutic efficacy for BMs whe

262 therapeutics for AD has been hampered by the difficulty in translating therapies that work in rodents

263 aggregation remains elusive due to the great difficulty in characterizing these complex and frequentl

264 ver, the use of the method is limited by the difficulty in deriving these groups.

265 ding is limited, in part due to the inherent difficulty in studying these branched, multi-isomer stru

266 The difficulty in understanding these functions can be at le

267 The key difficulty in articulating this relationship is that sha

268 This is primarily due to the difficulty in characterizing this modification and due t

269 A fundamental difficulty in determining this action, however, is that

270 rly sensitive to ROS is discussed, as is the difficulty in exploiting this hypersensitivity to tiopro

271 The difficulty in predicting this property hampers, however,

272 Previous studies attributed the notorious difficulty in treating this state to strong double excit

273 Owing to the difficulty in combating thrips vectors with insecticides

274 nthesis and chemical stability, it still has difficulty in applying to highly sensitive (i.e. parts-p

275 Limitations of our model include difficulty in fitting to past trends in NVT IPD in some

276 r use of flexible bronchoscopy have included difficulty in navigating to the lung periphery, the avoi

277 Patients in both groups had difficulty in returning to their narratives after going

278 in interaction with MinD, suggesting it has difficulty in switching to the active form.

279 This complexity, combined with difficulty in measuring transcript abundance and high se

280 ver variability in this procedure as well as difficulty in distinguishing tumor from non-tumor cells

281 ercialized due to poor antigen stability and difficulty in obtaining unconventional release kinetics.

282 ailable deposition processes suffer from the difficulty in depositing uniform and reproducible coatin

283 sts is a tremendous challenge because of the difficulty in producing uniform active sites that can be

284 Due to the difficulty in synthesizing very large BBCPs, the fidelit

285 man vocal fold (VF) mucosa models because of difficulty in procuring VF epithelial cells, epithelial

286 Due to the difficulty in distinguishing viridans group streptococci

287 nuous positive airway pressure adherence and difficulty in achieving weight loss.

288 novel small alien fragments may explain the difficulty in developing well-adapted lines carrying Wsm

289 se intermediates is severely hampered by the difficulty in obtaining well-diffracting crystals of tra

290 The difficulty in identifying what behaviors qualify as new

291 pread implementation has been limited by the difficulty in choosing where to interrupt the protein se

292 in poorly understood, in part because of the difficulty in discerning where CaMKII binds in live cell

293 of cancer face many challenges, notably the difficulty in distinguishing whether a test performed in

294 e existence of 4 main DENV serotypes and the difficulty in defining which individuals have been expos

295 ape behavior, however, is unknown due to the difficulty in discerning which mouse in a group is vocal

296 instead on local conditions and point to the difficulty in sustaining whole-ocean euxinia.

297 into consideration the infiltrative nature, difficulty in obtaining wide margins, high recurrence ra

298 ensing techniques is often hampered by their difficulty in dealing with mixtures of analytes, a drawb

299 A key difficulty in working with gas-phase samples, especially

300 Given the cost and difficulty in handling wooden barrels, and as an alterna