ライフサイエンスコーパス: dimer formation

1 r formation) or the homoallylic double bond (dimer formation).

2 evolutionary origin of matched isotype mixed dimer formation.

3 ss and PI3K effector interactions, abolishes dimer formation.

4 nced agonists with respect to selectivity of dimer formation.

5 sion increased with concentration because of dimer formation.

6 the Ad-FX interaction showed no evidence of dimer formation.

7 t Moco is necessary and sufficient to induce dimer formation.

8 nhibit DPPIV was through blocking the active dimer formation.

9 dimers, and their activity is dependent upon dimer formation.

10 e N-terminal residues, which are involved in dimer formation.

11 active site geometry, rather than preventing dimer formation.

12 -dependent catalysis, and by modulating eNOS dimer formation.

13 orting motifs and is a process that enhances dimer formation.

14 perone, phosducin-like protein 1 (PhLP1) for dimer formation.

15 from the sensor kinase PhoR was enhanced by dimer formation.

16 xists in a closed conformation that inhibits dimer formation.

17 atalytic domain, contribute to the PRK2-PRK2 dimer formation.

18 ysteine residue at the N-terminus to mediate dimer formation.

19 ge of the 30S head domain that promotes 100S dimer formation.

20 trate that CerS activity can be modulated by dimer formation.

21 he N terminus of CtIP, which is required for dimer formation.

22 mutant exhibited a significant reduction in dimer formation.

23 gning RNA-seq adapters that minimize adapter dimer formation.

24 ch suggests that this region is critical for dimer formation.

25 ys(4) that resulted in substantially reduced dimer formation.

26 oposed ED dimer interfaces have no effect on dimer formation.

27 sociation of myosin VIIA to vesicles and the dimer formation.

28 inucleotide binding domain that orchestrates dimer formation.

29 t bind dsRNA and one that is responsible for dimer formation.

30 isulfide bond formation is not essential for dimer formation.

31 e almost abolished iNOS activity and reduced dimer formation.

32 ones influence the specificity of Gbetagamma dimer formation.

33 but this interaction does not contribute to dimer formation.

34 er TonB, ExbB nor pmf were required for ExbD dimer formation.

35 alponin homology domain but does not require dimer formation.

36 or remediating biases and decreasing adapter dimer formation.

37 Hda domains in a conformation that promotes dimer formation.

38 s of microtubule formation without affecting dimer formation.

39 hese proteins and wild-type SecA in terms of dimer formation.

40 termolecular contacts that are important for dimer formation.

41 egments in MYA1 contributed significantly to dimer formation.

42 re extended hydrophobic surfaces involved in dimer formation.

43 tive site and help explain the importance of dimer formation.

44 ificant contributions to the active site and dimer formation.

45 o helices from another subunit, resulting in dimer formation.

46 g step in the fibrillization pathway was tau dimer formation.

47 Glu-49-Asn-53 loop, which, in turn, disrupts dimer formation.

48 portance of protein-protein interactions for dimer formation.

49 ereas the fourth helices participate only in dimer formation.

50 common G2385R polymorphism mainly compromise dimer formation.

51 ng hydrophobic contribution to the energy of dimer formation.

52 omeric cadherin pool, thereby inhibiting new dimer formation.

53 in receptor-receptor interactions underlying dimer formation.

54 deR variant that showed reduced affinity for dimer formation.

55 dant formulation efficiently reduced thymine dimer formation.

56 which was attributable to cysteine-mediated dimer formation.

57 es that determine the efficacy of Gbetagamma dimer formation.

58 predicted coiled-coil region does not drive dimer formation.

59 H2-terminal region is not required for MEKK2 dimer formation.

60 ys-662 and -716 conferred protection against dimer formation.

61 uptake, consistent with a role for alphaB in dimer formation.

62 mice, suggesting that CD45-AP inhibits CD45 dimer formation.

63 a molecular dynamics approach to study Abeta dimer formation.

64 nd long-range recognition mechanism for this dimer formation.

65 lations might be important for efficient DAO dimer formation.

66 hanges in photophysics of a chromophore upon dimer formation.

67 ting the role of protonated E73 in enhancing dimer formation.

68 therapeutic strategies including inhibiting dimer formation.

69 c TCR for surface expression and allow mixed dimer formation.

70 ine 286 and aspartates 96 and 107 are key to dimer formation.

71 to the adjacent unit to promote noncovalent dimer formation.

72 ve charge of the arginine/lysine residue for dimer formation.

73 in the FGF14.Nav1.6 complex and FGF14:FGF14 dimer formation.

74 mains of CFHR5 contact properdin and mediate dimer formation.

75 npi* excited states does not lead to thymine dimer formation.

76 Ac at potential glycosylation sites inhibits dimer formation.

77 g to Nav1.6 but had no effect on FGF14:FGF14 dimer formation.

78 are found to disrupt the dimer interface and dimer formation.

79 s, enables ATP-dependent nucleotide sandwich dimer formation.

80 raction while it is dispensable for S18-2/S6 dimer formation.

81 ii) phosphorylation of H379 in PRD2 disrupts dimer formation.

82 nds and likely responsible for initial Abeta dimer formation.

83 The fusion does not disrupt dimer formation, a necessity for catalytic activity.

84 nd in plasma, lipids and proteins "catalyze" dimer formation, a process that could occur either intra

85 dence from the intrinsic kinase activity and dimer formation ability of EGFR, and it largely avoided

86 oxidative stress-dependent decrease in Mge1 dimer formation accompanied by a concomitant decrease in

87 We report that the UBN1 middle domain has dimer formation activity and binds to H3/H4 in a manner

88 These results support the idea that dimer formation allosterically activates unphosphorylate

89 clot stiffness, in particular through gamma-dimer formation; alpha-gamma hybrid cross-links had the

90 s at different time points revealed covalent dimer formation already 15 min after fibrillation reacti

91 The ability of CD to induce actin dimer formation and actin-catalyzed ATP hydrolysis may b

92 n interact with a full-length GPCR, blocking dimer formation and affecting its function.

93 rine hearts prevented the p38-MKK3 disulfide dimer formation and attenuated H2O2-induced contractile

94 he interface of the DLC dimer, disrupts DLC1 dimer formation and consequently impairs its interaction

95 Increased J- and H-type dimer formation and decreased fluorescence emission were

96 helix formation decreased apparent Zq domain dimer formation and decreased Zq interaction with the al

97 zation, defining a thin reaction shell where dimer formation and dissociation take place.

98 These systems describe dimer formation and dissociation, protein preduction and

99 rmed the correlation between in vitro ED RNA dimer formation and efficient virus replication, thus in

100 A detailed characterization of dimer formation and estimates of the free energy of asso

101 c kinase that undergoes trans-regulation via dimer formation and extensive intramolecular and intermo

102 The C15-124 disulfides are not critical for dimer formation and have insignificant impact on the dit

103 veal a new signature motif that enables McdA dimer formation and indicates that, similar to DNA segre

104 These peptides efficiently blocked MMP-9 dimer formation and inhibited motility of COS-1 cells ov

105 -19, and Ser-20) is necessary for Gbetagamma dimer formation and is believed to be mediated by the pr

106 of the U-box dimer interface abrogates U-box dimer formation and is lethal in vivo.

107 ides a framework for understanding secondary dimer formation and lateral signaling in the EGF recepto

108 or positively charged lysine did not affect dimer formation and maintained around 60% of iNOS activi

109 ovide unique mechanistic insights into K-Ras dimer formation and membrane organization as well as the

110 eness of this mutant does not correlate with dimer formation and monomerisation, indicating that mono

111 RET-TM underlies - and may be required for - dimer formation and oncogenic activation of juxtamembran

112 3/M3-S2 linker of GluN1, but not GluN2, show dimer formation and oxidation-induced changes in current

113 ined the conformational changes triggered by dimer formation and phosphorylation, aimed to provide a

114 t in the midnanomolar range, suggesting that dimer formation and possibly also disulfide bond formati

115 although both proteins influence holoenzyme dimer formation and precursor tRNA recognition to differ

116 fic disulfide reductant, both decreased Arr1 dimer formation and protected photoreceptors from light-

117 nt complementation to measure ligand-induced dimer formation and radioligand binding to study the eff

118 on sites at the monomer-monomer interface on dimer formation and stability were determined.

119 ated the functional significance of Hpo homo-dimer formation and subcellular localization in living c

120 te that deprotonation of His 55 is linked to dimer formation and that mutation of His 55 to a small n

121 chemical mechanisms that determine NF-kappaB dimer formation and the signal-processing characteristic

122 A639G/A641R mutations significantly reduced dimer formation and transforming activity in this otherw

123 nterface may hinder or facilitate asymmetric dimer formation and transphosphorylation, respectively.

124 appear to have the greatest affinity for QD dimer formation and, therefore, gave the greatest yields

125 e identify mutations that restore defects in dimer formation and/or trafficking.

126 RNA sites without perturbing RNA folding and dimer formation, and a total of 17 internitroxide distan

127 ative injury led to Hsp27mRNA up-regulation, dimer formation, and Hsp27 phosphorylation in ARPE-19 ce

128 rect involvement of the polyalanine tract in dimer formation, and indicate that mutated proteins reta

129 ssays for atlastin-catalyzed GTP hydrolysis, dimer formation, and membrane fusion.

130 se voltage must pass a certain threshold for dimer formation, and pulse polarity determines the yield

131 tion model of ezrin, elucidate the basis for dimer formation, and reveal that a mutant generally cons

132 that disulfides play only a marginal role in dimer formation, and that the stability imparted by the

133 most substrates, hydrolysis and head-to-tail dimer formation are avoided.

134 double bond isomerization, elimination, and dimer formation are competitive undesired pathways.

135 requirements, mechanism, and specificity of dimer formation are still incompletely understood, but r

136 eractions between protein species, caused by dimer formation, are effectively negative.

137 Here, we identify RKIP dimer formation as an important mechanistic feature in t

138 acted F-ATP synthase, resulting in decreased dimer formation as revealed by blue-native electrophores

139 The velvet domain is also involved in dimer formation as seen in the solved crystal structures

140 ependent IgG4 structures in addition to IgG4 dimer formation at high concentration in heavy water.

141 rativity decreases and the dominant mode for dimer formation becomes interglutamine hydrogen bonding.

142 rstanding of the mechanism of radical cation dimer formation between constitutionally different TTF u

143 mechanism for activation is via drug-induced dimer formation between CRAF and kinase suppressor of Ra

144 s showed heterotrimer assembly to begin with dimer formation between globular G2alpha2 and the G2alph

145 fic hotspot to form membrane interaction and dimer formation, both Raf and its upstream binding partn

146 he interlocking aromatic residues eliminates dimer formation but does not affect PXR's ability to int

147 utated to asparagine is strongly impaired in dimer formation but mediates UV-B responses in vivo with

148 bunits and that CCT/TRiC mediates Gbetagamma dimer formation by an ATP-dependent reaction.

149 ts were predominantly monomers with impaired dimer formation by analytical ultracentrifugation (K(d)=

150 conserved segment in HUWE1 that counteracts dimer formation by associating with the dimerization reg

151 They do not form dimer contacts but enable dimer formation by inducing a strong membrane curvature

152 A comparison with studies of dimer formation by other physical techniques indicates t

153 ions in the domain-swap interface diminished dimer formation by the FOXP3 forkhead domain without com

154 These data provide the first evidence for dimer formation by the Na (+)-Ca (2+) exchanger.

155 penultimate positions in this chain rescued dimer formation by the phosphomimic.

156 ter partial pressures and (ii) maximizing Cu dimer formation by using zeolites with high Al content a

157 namics, surface corrugation, and competing H-dimers formation by means of ab initio molecular dynamic

158 Active dimer formation can be induced by increasing the protein

159 We find that pi-dimer formation can proceed via an asynchronous concerte

160 of tissue plasminogen activator, and lower d-dimer formation compared with nondiabetic AdMSCs.

161 The probability of coiled coil dimer formation computed for RetGC1/NPRA chimeras, even

162 Interestingly, the impaired FGG-dimer formation could be restored in NEC plasma by the a

163 hemical behavior of o-fluoranil has revealed dimer formation, cycloaddition to alkenes, and hydrogen

164 otect the T75C tetramer against heat-induced dimer formation, demonstrating the contribution of catio

165 SAT-6 with CFP10 under conditions that favor dimer formation did not affect inhibition of IFN-gamma.

166 ligands may result from partial agonism for dimer formation, differences in the kinetic pathway util

167 ive, the reaction was rendered selective for dimer formation (dimer/trimer > or = 16:1).

168 units, respectively, which are necessary for dimer formation) display a striking resistance to PTP op

169 We further show that disulfide-bond-mediated dimer formation does not affect and is not responsible f

170 anslation, which shifts the equilibrium from dimer formation dramatically in favor of viral capsid as

171 The turbidity and the rate of gamma-gamma dimer formation for BbetaD432A were indistinguishable co

172 e TMs, but it did increase the efficiency of dimer formation for the Ste2-V183C mutant.

173 JAM-A mutants incapable of dimer formation form complexes with the sigma1 head that

174 The potential for dimer formation from the nucleophilic addition of 2-meth

175 eins and carries the potential risk of mixed dimer formation giving rise to a new TCR with unpredicta

176 Finally, mutations that disrupted dimer formation had reduced calcium mobilization in resp

177 ns, none of which had a noticeable effect on dimer formation; however deletion of the C-terminal tail

178 e coiled-coil domain in COP1, which prevents dimer formation, impairs COP1 function in coordinating f

179 lecular masses with a reduced propensity for dimer formation in a cross-linking reaction.

180 ations to study monomer folding dynamics and dimer formation in CI2-polyQ chimeras with insertion len

181 , which allowed us to observe spontaneous gA dimer formation in lipid bilayers.

182 studies support the preeminence of enhanced dimer formation in quercetin's mechanism of action.

183 identified disulfide bond-mediated PHD2 homo-dimer formation in response to oxidative stress caused b

184 bi-component leukocidins, are essential for dimer formation in solution and receptor binding.

185 In contrast, dimer formation in solution is observed only in the pres

186 FCS measurements for probing dimer formation in solution over a range of protein conc

187 A tendency toward ED-B-dependent dimer formation in solution was supported by size exclus

188 in-distribution results in a selective sigma-dimer formation in solution, as confirmed by 2D NMR spec

189 envelope of PECAM-1 IgL1-6 supported such a dimer formation in solution.

190 Da and equilibrium association constants for dimer formation in the range 2 x 10(3)-6 x 10(5) M(-1).

191 ht into the amino acid residues that mediate dimer formation in the wild-type protein.

192 e data show that acidification causes Cx43CT dimer formation in vitro.

193 n system, we further demonstrated that MEKK2 dimer formation in vivo augmented MEKK2-dependent JNK ac

194 tion of the C-terminal tail region prevented dimer formation in vivo.

195 link nonspecific DNA backbone contacts with dimer formation, in addition to providing a new role for

196 Excision-seq to identify sites of pyrimidine dimer formation induced by UV light exposure, where the

197 Asymmetric dimer formation induces an allosteric conformational cha

198 Moreover, prevention of MEKK2 dimer formation inhibited MEKK2-mediated JNK activation.

199 Mutation of arginine 286 to alanine impairs dimer formation, interaction with COP1 and function in v

200 gest that the increased RNA affinity through dimer formation is a crucial parameter enabling these pr

201 In these catalytic reactions, Pd(I) mu-allyl dimer formation is a deleterious process which removes t

202 Central to dimer formation is a domain swap of the conserved C-term

203 Dimer formation is accelerated by H(2)O(2) and hindered

204 Dimer formation is achieved through mutual pairing of G1

205 Whether dimer formation is an important structural component of

206 The frequency of chromosome dimer formation is approximately 15% per generation in w

207 The dimer formation is critical for Hsp40 molecular chaperon

208 al form of the ScBOR1p is the dimer and that dimer formation is dependent on association with membran

209 However, it remains unclear whether dimer formation is dependent on protein-lipid interactio

210 This dimer formation is eliminated here by covalent attachmen

211 ies of chronophin(A194K,A195K) revealed that dimer formation is essential for an intermolecular argin

212 These studies suggest that CtIP dimer formation is essential for its recruitment to DSBs

213 e serious consequences arise when chromosome dimer formation is increased, or their resolution effici

214 a membrane-miscible lipid tail, we show that dimer formation is mediated by protein interactions and

215 In Escherichia coli, 100S dimer formation is mediated by ribosome modulation facto

216 nstitutive homodimers in live cells and that dimer formation is not modulated by SERCA conformational

217 the ATP synthase monomer is sufficient, and dimer formation is not required, for mPTP activity.

218 activity and salt-dependence indicates that dimer formation is of functional significance in both ca

219 mer during DNA repair, but it is unclear how dimer formation is regulated or what the functions of th

220 Therefore, OPG dimer formation is required for the mechanism of inhibit

221 e calculations support the view that the R6G dimer formation is the most plausible cause for the comp

222 Inhibition of cyclic dimer formation is vital for increasing the yield of lin

223 which dictates the selectivity of the sigma-dimer formation, is rationalized by evaluating the aroma

224 activity of E2-25K, as measured by ubiquitin dimer formation, is strikingly enhanced when added to pe

225 nterface domains of the EGFR can induce EGFR dimer formation, leading to aberrant receptor activation

226 meras we find that the residues required for dimer formation lie between amino acids 751 and 998 of (

227 Dimer formation may also involve TSPN-1 domains from two

228 sual for this enzyme class and suggests that dimer formation may contribute to light activation of th

229 ecting E-cadherin cellular localization, cis-dimer formation, molecular assembly and stability of the

230 Dimer formation occurs by specific interaction between i

231 Gbetagamma dimer formation occurs early in the assembly of heterotr

232 tion of the first step of amyloid initiation-dimer formation of a seven residue peptide (NHVTLSQ) fro

233 acentrifugation to obtain an apparent Kd for dimer formation of about 55 microM.

234 Noncovalent dimer formation of abundant components has not previousl

235 ly regulates autophagy by promoting inactive dimer formation of Beclin-1.

236 o-6-hydroxypyrimidine during shear inhibited dimer formation of endothelial NO synthase, increased en

237 Asymmetric dimer formation of epidermal growth factor receptor (EGF

238 ) or DsrA(DII) and suggests that RNA-induced dimer formation of Hfq(6) is a common feature of Hfq-RNA

239 the mechanism of formation and regulation of dimer formation of iNOS.

240 We further indicate a lipid-dependent dimer formation of MraY translocase correlating with the

241 These results suggest that dimer formation of myosin VIIA is important for its carg

242 ormational stabilization by disulfide-linked dimer formation of synthetic V1V2 peptides were required

243 tipulates whether, in the absence of ligand, dimer formation of the aptamer competes with intramolecu

244 T efficiency and estimate the free energy of dimer formation of the G380R mutants of fibroblast growt

245 Residues associated with p53 dimer formation on DNA are poorly conserved in the p63 a

246 Here we report Ras dimer formation on membranes by Type II photosensitizati

247 By measuring the free-energy cost of dimer formation on monolayers of increasing uniaxial str

248 two subdomains of PLC-beta3 are involved in dimer formation, one in the catalytic X and Y domains an

249 on of the unpaired cysteine does not inhibit dimer formation or biological activity.

250 Neither dimer formation or dissociation are clearly favored, and

251 not due to structural perturbation, impaired dimer formation or the loss of plasminogen binding.

252 ting different types of information, such as dimer formation or the presence of open binding faces on

253 molecules is proposed to be best obtained by dimer formation, promoting supramolecular double helices

254 In summary, disrupted eNOS dimer formation rather than impaired insulin mediated eN

255 Dimer formation reappeared when arginine mutants were mi

256 re only modestly affected by solvation or by dimer formation, remaining in the range of 9-12 kcal/mol

257 CAPS dimer formation required its C2 domain based on mutation

258 For EF-hand 4, dimer formation requires only one of the monomers to be

259 ns, CA(N) and CA(C), which drive hexamer and dimer formations, respectively, to form a capsid lattice

260 Because the mutations leading to dimer formation resulted in poor thermostability of the

261 a NickRCA-based magnetic nanoparticle (MNP) dimer formation strategy combined with a real-time optom

262 r ligands, AREG showed biphasic kinetics for dimer formation, suggesting that its path for EGF recept

263 sed whereas the C162S mutation increased the dimer formation, suggesting that these two Cys residues

264 The effect of ligand on dimer formation suggests that dimers are formed in the r

265 form a wiring diagram to delineate NF-kappaB dimer formation that emphasizes that inflammatory and de

266 ially by maintaining stability of the hetero-dimer formation that might have been related to dietary

267 Herein, we outline a unique strategy for dimer formation that obviates these difficulties, one wh

268 HARPIN bound caspase 1 and disrupted p20/p10 dimer formation, the last step of caspase 1 processing,

269 and structurally alphaE- and alphaN-catenin dimer formation, their interaction with beta-catenin and

270 A reduced level of dimer formation then results from the reduced ratio of t

271 nformations act as competitive inhibitors of dimer formation, thus lowering affinities even when the

272 These results link the loss of dimer formation to a loss of PAR4 signaling.

273 quilibrium model, we estimate the DeltaG for dimer formation to be -10.2 +/- 2.3 kJ/mol.

274 Cross-linking assays confirmed dimer formation to be enhanced in the presence of elevat

275 e probability and rate of beta-sheet amyloid dimer formation to be higher and faster at the air-water

276 However, most mutations affect dimer formation (to enhance or weaken).

277 ential affinity of alpha2(IV) NC1 domain for dimer formation underlies the driving force in the mecha

278 the FGF14.Nav1.6 complex and the FGF14:FGF14 dimer formation using a luciferase assay.

279 and Sema2b show stabilisation of sema domain dimer formation via a disulfide bond.

280 the importance of these sequence elements on dimer formation via gel mobility shift assays and size e

281 n which kinetic mechanisms control NF-kappaB dimer formation via processing and assembly of large com

282 IgG2 dimer formation was <=5% and independent of the buffer c

283 resulted in pro-hIAPP dimer formation, while dimer formation was absent or reduced dramatically in ce

284 170, the role of hydrophilic interactions in dimer formation was also demonstrated.

285 The quantum yield of cyclobutane pyrimidine dimer formation was calculated as the number of dimeriza

286 In the PhLP1-depleted rods, Gbetagamma dimer formation was decreased 50-fold, resulting in a >1

287 Moreover, UV-induced cyclobutane pyrimidine dimer formation was markedly enhanced in ribonucleotide-

288 were mutated one at a time to cysteine, and dimer formation was measured by the rate of disulfide bo

289 tic light scattering experiments showed that dimer formation was not disrupted, nor did higher-order

290 tic light scattering experiments showed that dimer formation was not interrupted.

291 Dimer formation was shown to be dependent on micelle com

292 Decamers of amyloid beta peptide capable of dimer formation were selected as a test system.

293 atenin is in a unique unfurled mode allowing dimer formation when bound to vinculin.

294 extent of cross-linking is limited mostly to dimer formation, whereas mutants in which Y39 along with

295 prevented MEKK2 activation by blocking MEKK2 dimer formation, which in turn blocked JNKK2, c-Jun N-te

296 with the NS5A protein of HCV and inhibit its dimer formation, which is essential for HCV replication.

297 murine beta cell line resulted in pro-hIAPP dimer formation, while dimer formation was absent or red

298 s been proposed to play an important role in dimer formation with another protein from the Fo-sector.

299 otypes require phosphorylation of Y(711) and dimer formation with full-length Stat92E.

300 a cysteine reporter diagnostic for trimer-of-dimer formation yielded cross-linking products upon trea