ライフサイエンスコーパス: dimer interface

1 ant role in maintaining structure across the dimer interface.

2 hat both occurs through the crystallographic dimer interface.

3 eases the side chain of His23 from the dimer-dimer interface.

4 domain reveal the molecular nature of the CC dimer interface.

5 ith neonatal microcephaly, is located at the dimer interface.

6 es a central hydrogen bonding network at NS1 dimer interface.

7 tein motions, consistent with a destabilized dimer interface.

8 ing two modulator-binding sites at the GluK1 dimer interface.

9 hat it can be activated by disruption of the dimer interface.

10 ween specific charged amino acids across the dimer interface.

11 homodimer of ACT folds with Phe bound at the dimer interface.

12 nces in how the subunits are arranged at the dimer interface.

13 ent manner to form a ferroxidase center at a dimer interface.

14 ue quaternary epitope on the E protein dimer-dimer interface.

15 ium with the Cys(257) residue located on the dimer interface.

16 e protruding Jalpha helix and on the LOV-LOV dimer interface.

17 interactions observed at the N. clavipes NTD dimer interface.

18 r identifies subunits e and g at the lateral dimer interface.

19 d cooperatively recognize the antigen in the dimer interface.

20 ent active dimers and revealed the preferred dimer interface.

21 ces in aromatic-aromatic interactions at the dimer interface.

22 value and is located within the hydrophobic dimer interface.

23 nsport core and TM11-TM12 helices lining the dimer interface.

24 quely in RECQ1) is buttressed by the protein dimer interface.

25 rk of hydrogen bonds and salt bridges at the dimer interface.

26 ent of conserved proline residues across the dimer interface.

27 outer edges, and basic side grooves near the dimer interface.

28 kp1-Rnl-Hen1 heterotrimer fused at the Pnkp1 dimer interface.

29 a number of sites near the crystallographic dimer interface.

30 f the dimer, we mutated five residues on the dimer interface.

31 id the design of inhibitors that bind at the dimer interface.

32 etrical dimer with a large deep cleft at the dimer interface.

33 otential Zn(2+)-binding sites outside of the dimer interface.

34 h recapitulating the role of Phe(B24) at the dimer interface.

35 cal frame-work with protruding spikes at the dimer interface.

36 f transmembrane helix IV, is observed at the dimer interface.

37 t this site restricts its involvement at the dimer interface.

38 r part of, or allosterically coupled to, the dimer interface.

39 lly coupled, conveying inhibition across the dimer interface.

40 which forms part of the mariner transposase dimer interface.

41 g of protomers through two histidines at the dimer interface.

42 on of binding kinetics by mutations at the X-dimer interface.

43 cooperativity due to steric hindrance at the dimer interface.

44 nt, with two nucleotides "sandwiched" at the dimer interface.

45 phate (Fru-6-P), binds along the other dimer-dimer interface.

46 on of the chemokine, which overlaps with the dimer interface.

47 etworks in the active-site cavity and at the dimer interface.

48 g the C-terminal residues that stabilize the dimer interface.

49 lectrostatic interactions that stabilize the dimer interface.

50 dimer by introducing a disulfide across the dimer interface.

51 entire active site, as well as 3 hits at the dimer interface.

52 iminished with disruption of the BRAF kinase dimer interface.

53 ut Trp/Arg side chains that stack across the dimer interface.

54 ons of the surface residues that mediate the dimer interface.

55 ing site on SLIP1 for SLBP lies close to the dimer interface.

56 hibitor binds in an allosteric manner at the dimer interface.

57 dimer with two (p)ppGpp binding sites at the dimer interface.

58 mental data that suggest coordination in the dimer interface.

59 omodimer with a dicopper Cu(A) center at the dimer interface.

60 eveals a binding site for the 3' cRNA at the dimer interface.

61 GyrA WHD and GyrB TOPRIM domains across the dimer interface.

62 on of the C domains that disrupts the normal dimer interface.

63 ward the ligand fingertips and away from the dimer interface.

64 immunity are conformational epitopes at the dimer interface.

65 Instead, TM2, TM6, and TM11 line the dimer interface.

66 ATPase, positions of the main domains, and a dimer interface.

67 PP2A/RACK1 binding site is buried within its dimer interface.

68 ) in the predicted, tightly packed TM domain dimer interface.

69 dine (HAP) pocket between core protein dimer-dimer interfaces.

70 kinetics of receptor association at specific dimer interfaces.

71 ral rearrangements specifically at the dimer-dimer interfaces.

72 ry to confirm APJ homo-dimer and explore the dimer-interfaces.

73 an R-state conformation with a lysine at the dimer-interface acting as a peg in a hole, locking the a

74 Disrupting the observed dimer interface affects particle assembly and overall sp

75 d modeling, we find that the subunits form a dimer interface along the entire length of S1, and also

76 soflurane and sevoflurane bound to both TLR9 dimer interface and 5'-xCx DNA binding site.

77 a homologous BH4-binding site located in the dimer interface and a conserved tryptophan residue that

78 ng in the rearrangement of the kinase domain-dimer interface and a rotation of the RNase domains away

79 both AtPRK and CrPRK have a strongly reduced dimer interface and an increased number of random-coiled

80 in the amino acids located primarily at the dimer interface and at the C-terminal region of IFN-gamm

81 ALLINIs bind at the IN catalytic core domain dimer interface and bridge two interacting subunits.

82 re of apo-FAcD exhibits asymmetry around the dimer interface and cap domain, priming one protomer for

83 ent activation of IRF3 and thus excludes the dimer interface and CBP-binding site.

84 that structurally stabilized the EGFR kinase dimer interface and conferred sensitivity to kinase inhi

85 mutations of BRCA1 are found to disrupt the dimer interface and dimer formation.

86 ed stabilization of aromatic clusters at the dimer interface and enhancement of intersubunit hydrogen

87 ovine rhodopsin (Rho) to investigate the Rho dimer interface and functional consequences of its disru

88 a positively charged Arg residue at the beta-dimer interface and high NaCl concentrations destabilize

89 A positively charged cavity is formed on the dimer interface and involves several strictly conserved

90 nating in the epicenter further disrupts the dimer interface and leads to dimer dissociation.

91 H1 indicates that the inhibitor binds at the dimer interface and makes direct contact with a residue

92 iochemical analysis, reveal a lipid mediated dimer interface and mechanism for coordinating structura

93 in live cells confirm that mutations at the dimer interface and peripheral site produce effects comp

94 hat disrupts the BC-loop regions at the P450 dimer interface and results in a CYP126A1 monomeric crys

95 lly those residing at barttin binding sites, dimer interface and selectivity filter.

96 and PHF19 associate with PRC2 at around the dimer interface and stabilize the dimer.

97 rs of thymidylate synthase (hTS) bind to the dimer interface and stabilize the inactive form of the p

98 nally to the interhelical axis and spans the dimer interface and that heparin binding enhances the st

99 lay of more than one amino acid at the dimer-dimer interface and the C-terminal unstructured tail.

100 lex) confirm structural coupling between the dimer interface and the catalytic center.

101 The structure suggests that ATM/Tel1 dimer interface and the consecutive HEAT repeats inhibit

102 are non-native oligomers in which the native dimer interface and the electrostatic loop mediate the f

103 Our results show that residues at the dimer interface and the switch II region of Toc159G are

104 alcohol dehydrogenase (ht-ADH): Y25A (at the dimer interface) and V260A (at the cofactor-binding doma

105 5 was identified as being located in the A52 dimer interface, and consistent with that, A52-M65E was

106 ate altered hydrogen-bonding patterns at the dimer interface, and cross-correlation analysis showed t

107 These mutations resided in the dorsal flaps, dimer interface, and GTP-binding regions of the catalyti

108 dy binds to E proteins residues at the intra-dimer interface, and the virus quaternary structure-depe

109 onserved ATP-binding pocket that lies at the dimer interface, and we identify key residues in this bi

110 ingle position of the allosteric site of the dimer interface, and we show that the enzyme activity va

111 We noted that residues at the dimer interface are also present in LsdB, another lignos

112 monstrate that the KAR M3-S2 linkers and LBD dimer interface are critical determinants for Neto2 modu

113 a10/I24N), in which the beta1-strands at the dimer interface are extruded and available to bind MinD,

114 dues in the C-terminal CA subdomain (CA-CTD) dimer interface are needed for the stability of the firs

115 We also identify the D1 dimer interface as a novel site of Neto2 modulation and

116 f channel opening by F508del and support the dimer interface as a target for cystic fibrosis therapeu

117 d for Raf function, thus identifying the Raf dimer interface as a therapeutic target.

118 harmacophore, binds at the same GluN1/GluN2B dimer interface as ifenprodil but adopts a remarkably di

119 mission of conformational changes across the dimer interface as the most probable mechanism of altere

120 erivatives target a similar pocket at the IN dimer interface as the quinoline-based ALLINIs, the lead

121 ensitizing conditions, the largely decoupled dimer interface at the agonist-binding domain as seen in

122 nd cross-linking studies show that the dimer-dimer interface at the agonist-binding domain mediates t

123 onal and structural studies suggest that the dimer interface at the agonist-binding domain plays a ke

124 c IN inhibitors (ALLINIs) that engage the IN dimer interface at the binding site for the host protein

125 ic acid derivatives that bind at the CCD-CCD dimer interface at the principal lens epithelium-derived

126 As expected, a peptide corresponding to the dimer interface became more solvent exposed over time at

127 kbone H-bonding interactions by substituting dimer interface beta-strand residues with proline (Pro)

128 he SelA catalytic site is close to the dimer-dimer interface, but the significance of the dimer penta

129 We confirmed this dimer interface by double electron-electron resonance me

130 the protein, where it is coordinated at the dimer interface by main chain carbonyl oxygen atoms from

131 of the mutants can facilitate access to the dimer interface by small molecules and thereby aid the d

132 tion of the beta3- and beta3'-strands at the dimer interface; changes in the second are more extensiv

133 ntified a possible lipid binding site at the dimer interface comprising residues Arg265, Arg267, Arg4

134 import, the Toc159G dimer disengages and the dimer interface contacts translocating preproteins, whic

135 ablating a portion of the catalytic core and dimer-interface contacts of native TyrRS, each folded in

136 tent with binding of one molecule of 11m per dimer interface, contrary to most benzothiadiazine dioxi

137 ting that Leu29 and Leu36 are located at the dimer interface, contributing to the structure and stabi

138 y engineering rho-benzoylphenylalanine along dimer interfaces corresponding to the five different Sec

139 These various sites and the conserved dimer interface could be exploited for the development o

140 interface, suggesting that the cavity in the dimer interface could serve as an allosteric site of hTS

141 istent with the experimental data from which dimer interfaces could be deduced.

142 Structure-guided mutational analyses of RopB dimer interface demonstrated that single alanine substit

143 Ten years after the definition of the RAF dimer interface (DIF) by crystallography, this review fo

144 imeric in solution and in crystals, with the dimer interface displaying a surface groove that is line

145 region at triosephosphate isomerase (TIM)'s dimer interface, distant from its catalytic site, is a t

146 region at the active state asymmetric kinase dimer interface do not affect the stability of ligand-in

147 eas a CatC mutant with a disrupted CRAF-CRAF dimer interface does not.

148 ), which is also formed at the S100A8/S100A9 dimer interface, does not provide a high-affinity Mn(II)

149 nts--to the extracellular ligand binding and dimer interface domains of the EGFR can induce EGFR dime

150 ergoes dynamic motion that exposes the dimer-dimer interface during catalysis.

151 lts indicate that tryptophan residues at the dimer interface engage in photoinduced proton coupled el

152 that methylation of R198 and R200 within the dimer interface enhances growth factor ligand binding an

153 targeting the disulfide-bond stabilized LRX dimer interface fail to rescue lrx infertility phenotype

154 A large antiparallel dimer interface formed by the first 4 extracellular cadh

155 upies the UDG DNA-binding cleft, whereas the dimer interface forms a hydrophobic box to trap a mechan

156 hough CT263 lacks the active site-associated dimer interface found in prototypical MTANs, co-crystal

157 ivation also involves a reorientation of the dimer interface from a 'relaxed' to an 'active' state, b

158 ing dynamics to the substitution site in the dimer interface; G194C and G426E both led to minor struc

159 e lowest potential energy although its intra-dimer interface has the least free energy of formation.

160 Substituting a critical residue of the dimer-dimer interface, His-110, altered the tetramer dissociat

161 Substitutions at the dimer interface impaired IreB function and stability in

162 We demonstrate that a mutation at the GAPDH dimer interface impairs formation of the second RNA-GAPD

163 Mutating these dimer interfaces implicates one of them (dimer 1) in sol

164 A mutation at the dimer-dimer interface in a thermolabile psychrophilic homologu

165 dentified the structural determinants of the dimer interface in the active receptor, and validated th

166 ion mode is distinct from the widely studied dimer interface in the CA domain and from protein intera

167 sidues on the Escherichia coli SecA (ecSecA) dimer interface in the cytosol of intact cells.

168 ast, detergent-resistant lipids bound at the dimer interface in the leucine transporter show decrease

169 ciation, suggesting that stability of the D1 dimer interface in the ligand-binding domain (LBD) is an

170 nd C termini, subunit exchange, and variable dimer interfaces in ABC.

171 also reveal by crystallography two distinct dimer interfaces in the BTN3A1 full-length intracellular

172 t factors contribute to the stability of the dimer interfaces in the closed conformation and how clam

173 resolution shows distinct asymmetry near the dimer interface, in the region harboring catalytically i

174 The dimer interface includes hydrophobic and hydrophilic int

175 al-binding sites formed at the S100A8/S100A9 dimer interface, including a histidine-rich site compose

176 ific effects of oxidative "mutations" at the dimer interface, including lysine, arginine, proline and

177 ts are at a serotype-invariant site at the E-dimer interface, including the exposed main chain of the

178 aims to understand how the stability of the dimer interface influences clamp-opening dynamics and cl

179 me B prosthetic group present at the subunit dimer interface influences the stability and pressure la

180 the TREX1 Arg-62 residues extend across the dimer interface into the active site of the opposing pro

181 The purified protein was a dimer whose dimer interface involves interactions between the coiled

182 Finally, mutations at a dimer interface, involving fusion domains associated in

183 ced bending of a long signaling helix at the dimer interface is counteracted by the ligand-induced st

184 of the intermolecular disulfide, the Rgg2Sd dimer interface is destabilized and Rgg2Sd can adopt mul

185 hat the CC3 forms a parallel homodimer whose dimer interface is formed by a small number of hydrophob

186 P7B, does not disrupt dimerization, i.e. the dimer interface is formed by the domains that are conser

187 The dimer interface is formed entirely by phylum-specific co

188 cotranslational interactions until the LuxB dimer interface is fully exposed.

189 here suggested that a properly aligned RopB dimer interface is important for GAS pathogenesis and hi

190 x-ray scattering analysis indicated that the dimer interface is located at the C terminus and provide

191 The dimer interface is more efficient for attracting and bin

192 nformational states in which Domain 1 at the dimer interface is more flexible and prone to unfolding.

193 The dimer interface is suited to resist hydrodynamic force a

194 ) motif (site 2) formed at the S100A8/S100A9 dimer interface is the site of high-affinity Mn(II) coor

195 important than specific amino acids and the dimer interface is unique from other A3 enzymes.

196 ollowing model: Gag dimerizes via the CA-CTD dimer interface just before or during membrane targeting

197 N1/GluN2B N-terminal domain (NTD) upper lobe dimer interface leads to an irreversible allosteric inhi

198 mutated three conserved residues in the Nef dimer interface (Leu(112), Tyr(115), and Phe(121)) and d

199 dded in a pocket immediately adjacent to the dimer interface, linking the phosphorylation status of t

200 The X-dimer interface lowers the energy barrier associated wit

201 The A3G dimer structure has a hydrophobic dimer-interface matching with that of the previously rep

202 ackbone amide carbonyl positioned across the dimer interface may be responsible for the altered behav

203 he nonconserved amino acids distant from the dimer interface may control MERS-CoV 3CL(pro) dimerizati

204 The isoform-specific RI-holoenzyme dimer interface mediated by N3A-N3A' motifs defines mult

205 Short B7-2 dimer interface mimetic peptides bind diverse superantig

206 Nef dimer interface mutants also failed to trigger internali

207 A CA inter-hexamer dimer interface mutation led to a loss of induced PIP2 c

208 dies indicated that Cys-20 is located at the dimer interface near the DNA-binding surface.

209 e destabilization through mutagenesis of the dimer interface of a bacterial F(-)/H(+) antiporter, ClC

210 ate, but variation in B-cell epitopes at the dimer interface of DBP leads to induction of strain-limi

211 observation is that lithium ions bind to the dimer interface of GluK2/K5 heteromers and slow their de

212 We found that the dimer interface of HSPB5 is destabilized over physiologi

213 tigen receptor for chemokines (DARC) and the dimer interface of P. vivax DBP.

214 ents indicate that AXXXG motif is not on the dimer interface of p75-TM-WT, suggesting that the confor

215 d site-specific mutations into the BC domain dimer interface of Staphylococcus aureus PC (SaPC), equi

216 The dimer interface of Ste2 is formed by the N terminus, the

217 reveal that the PLPLRT/SD motif binds to the dimer interface of TBK1.

218 Last, we propose that the dimer interface of the BRAF(D594G):CRAF heterodimer may

219 4I) directly weaken inhibitor binding at the dimer interface of the catalytic core domain but at the

220 NVR-010-001-E2 binds at the dimer-dimer interface of the core proteins, forms a new intera

221 The compound is bound at the dimer interface of the CT domain, at a site equivalent t

222 This alpha-hairpin is located in the dimer interface of the Ec-NhaA homodimer together with a

223 revealed a binding site at the GluN1-GluN2A dimer interface of the extracellular ligand-binding doma

224 CSP-NMR-guided HADDOCK modeling of the dimer-dimer interface of the heterotetrameric complex exhibits

225 The modulators bind within the dimer interface of the ligand-binding domain (LBD) and s

226 chain of the T-cell receptor but also to the dimer interface of the T-cell costimulatory receptor CD2

227 for molecules of cholesterol at the dimer + dimer interface of the tetramer, which is consistent wit

228 e reveal the importance of the D-loop at the dimer interface of the two nucleotide-binding domains (N

229 l extension that structurally mimics a dimer-dimer interface of these enzymes that are canonically or

230 ar preferred supramolecular organization and dimer interfaces of ORs across the different receptor su

231 he preferred supramolecular organization and dimer interfaces of ORs in a cell membrane model.

232 l membrane Bax proteins form a BH3-in-groove dimer interface on the MOM surface similar to that obser

233 e existence of two structurally distinct M3R dimer interfaces, one involving i2/i2 contacts (TM4-TM5-

234 ve led to distinctly different proposals for dimer interfaces, one involving interactions of ABED bet

235 CLCNKB mutations in barttin-binding sites, dimer interface or selectivity filter often have severe

236 Mutations in the dimer interface, or of residues along an inhibitory path

237 DeltaE2-4 SV gave an alternative, neomorphic dimer interface 'orthogonal' to that of native TyrRS.

238 by engineering glycosylation sites into the dimer interface; other interface mutants remained dimeri

239 imer epitope (EDE), readily exposed at the E dimer interface over the region of the conserved fusion

240 The dimer interface overlaps with RIP2 CARD but not RhoGDI b

241 Importantly, we find that a dimer interface peptide can effectively block Raf dimeri

242 tional selectivity and plasticity at the NTD dimer interface play a role in the pH-dependent transiti

243 ing tRNA and instead repurposes it to form a dimer interface presenting a DNA-binding groove.

244 This DBD-LBD interaction masked CAR's dimer interface, preventing CAR homodimer formation.

245 ylation events directed to the extracellular dimer interface provide another mechanism to regulate th

246 ex hexagons, allosteric communication across dimer interfaces provides a pathway for receptor-generat

247 located at the surface and/or within the NS5 dimer interface, providing a functional significance to

248 ship between ligand binding, LBD closure and dimer interface rearrangement in activation remains uncl

249 an engineered disulfide bond across the NBD dimer interface reduces conformational fluctuations and

250 Genetic disruption of the predicted IpaH9.8 dimer interface reduces the solution molecular weight an

251 ing induces closure of the LBDs, followed by dimer interface reorientation.

252 The dimer-dimer interface requires an intricate hydrogen bonding n

253 structure of the STAT3 NTD and identified a dimer interface responsible for cooperative DNA binding

254 Destabilizing the dimer interface resulted in the loss of RSV filament for

255 whereas targeting an allosteric site in the dimer interface selects an inactive conformation that co

256 ineered Toc159 with a cysteine placed at the dimer interface showed increased cross-linking to bound

257 cal stability with core regions close to the dimer interface showing lower protection but some other

258 tide requires binding of cations to an intra-dimer interface site in the RCK dimer.

259 l loop II-strand 3, rather than the proposed dimer interface site.

260 ease with allosteric inhibitors bound to the dimer interface site.

261 tructure reveals that ParB binds at the ParA dimer interface, stabilizing the ATPase-competent ATP sa

262 Conserved loops at the CBD dimer interface straddle a conserved peripheral NBD heli

263 it that acts in trans; tRNAs bind across the dimer interface such that Trm6 from the opposing heterod

264 er by approximately 33 A across an extensive dimer interface, suggesting a mechanism in which polyhyd

265 , we identified a ligand-binding site in the dimer interface, suggesting that the cavity in the dimer

266 scussed in the context of a Trp49-containing dimer interface that acts as a conduit for thermally act

267 helical and beta-sheet domains at the native dimer interface that becomes exposed upon mutated SOD1 m

268 igher affinity is due to the residues in the dimer interface that create an attractive electrostatic

269 ion of a flexible loop proximal to the dimer-dimer interface that is essential for catalysis (i.e. th

270 he active conformation reveals an asymmetric dimer interface that is essentially the same as that in

271 n highly conserved residues across the RNase dimer interface that place key catalytic residues poised

272 d" SelA variants with mutations at the dimer-dimer interface that prevent pentamerization.

273 hat single amino acid mutations at the IL-37 dimer interface that result in the stable formation of I

274 londelta/gamma heterodimer revealed a unique dimer interface that results in a heterodimer with consi

275 ructural determinants at the GluN1/GluN2 NTD dimer interfaces that critically dictate UV-controlled i

276 Of all the inter-dimer interfaces, the CB interface has the least area an

277 eside closely on a loop that constitutes the dimer interface; their sidechains interact with the Pro7

278 ps leads to a compaction of the intersubunit dimer interface, thereby bringing the cysteine-rich doma

279 the location of the structural motifs in the dimer interface, thereby establishing that both sequence

280 coli beta-sliding clamp that destabilize the dimer interface to determine whether the formation of an

281 However, besides 8 tryptophans at the dimer interface to form two critical pyramid perception

282 Mutation of the dimer interface to make Set1C monomeric abolished H3K4me

283 fluorescence of a tryptophan located at the dimer interface to show that dimer dissociation occurs s

284 dues along an inhibitory pathway linking the dimer interface to the enzyme's active site, favour BiP

285 ve effect allosterically propagated from the dimer interface to the inhibitory Glu234, thereby permit

286 - and (p)ppGpp-bound tetramer, where a dimer-dimer interface triggers allosteric structural rearrange

287 ation of ligand-dependent signals across the dimer interface via an unknown structural mechanism.

288 Another dimer interface was formed inside the MOM by two interse

289 Drawing on structural analysis of the dimer interface, we identified a bacteriophytochrome in

290 nd binding are linked to the dynamics of the dimer interface, whereas the low activity and affinity f

291 with the two transmembrane helices being the dimer interface, whereas the N-terminal cytoplasmic doma

292 eproteins was observed preferentially at the dimer interface, whereas the transit peptide was found a

293 red an additional nickel-binding site at the dimer interface, which binds Ni(II) with an affinity of

294 that residue 178 was located near the dimer-dimer interface, which may affect VP1 assembly and oligo

295 hin or directly adjacent to CDR3 loop at the dimer interface, which remarkably include both destabili

296 veal remarkable structural similarity of the dimer interface with 3CL(pro) from HKU4-CoV and HKU5-CoV

297 ergetic coupling between residues across the dimer interface with spontaneous pore opening/closure in

298 ing is found between V(L)-V(L) and C(L)-C(L) dimer interfaces, with destabilization of one interface

299 first example of a functionally important TM dimer interface within an HCV nonstructural protein and

300 meric complexes on Psi RNA require an intact dimer interface within Gag.