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1 is the sole ribosome-dependent toxin that is dimeric.
2 analog bound-DnaA) was oligomeric, primarily dimeric.
3 ure of the BRAF(KD)-14-3-3 complex, in which dimeric 14-3-3 enforces a dimeric BRAF(KD) assembly to i
4 ed B-Raf kinase domain dimer in complex with dimeric 14-3-3, at a resolution of ~3.9 angstroms, shows
6 mbly is mediated by interactions between the dimeric 5'-leader of the unspliced viral RNA and the nuc
7 ribosome is a poorly understood form of the dimeric 70S particle that has been linked to pathogenesi
11 es of HsNudT16 in complex with monomeric and dimeric ADP-ribose in identifying the active site for bi
14 the mass fraction remaining of monomeric and dimeric alpha-pinene oxidation products on the filter vi
19 Our model predicts that after autoxidation, dimeric and monomeric hemichrome intermediates occur alo
20 phosphorylation or SHP-1 recruitment between dimeric and monomeric Siglec-E expressed on HEK293A cell
22 electron tomography to measure the amount of dimeric and polymeric tubulin at mitotic centrosomes in
24 ations of the on-pathway helical coiled-coil dimeric and tetrameric species (tau(ex) <= 50 to 70 mus)
27 complex of proteins associated with Set1) is dimeric and, consequently, symmetrically trimethylates h
32 angstrom resolution, respectively, reveal a dimeric arrangement of LRX proteins, with each monomer b
34 using cavitands that assemble into distinct dimeric assemblies, we show that this approach, which we
35 ral metal binding is not compulsory for PerR dimeric assembly and for regulating peroxide stress.
41 ) complexes [Cu(L(1-6))Cl] (1-6) formed weak dimeric associates in the solid state, which did not rem
45 mer also demonstrates that the structures of dimeric ATP synthases in a tetrameric porcine enzyme hav
46 e demonstrated, allowing easy preparation of dimeric AzaBPDI as potential non-fullerene acceptors for
48 y inhibits ERK signaling in tumors driven by dimeric BRAF mutants, including BRAF fusions and splice
50 cubane formation through reaction of the key dimeric building block [M(2)(dpy-C{OH}O)(2)(H(2)O)(4)](2
56 ein three types of nanocapsules, including a dimeric capsule, a Sierpinski triangular prism, and a cu
57 distinguishing from the 255 "Lambda"-shaped dimeric CATCs observed in murine cytomegalovirus and the
58 arget cells compared with monomeric sCD4 and dimeric CD4-Ig, we generated virus-like nanoparticles th
62 under nucleophilic catalysis conditions with dimeric cinchona alkaloids, providing excellent enantioc
64 ando X-ray absorption spectroscopy, reveal a dimeric Co-Fe moiety as the active site of the catalyst.
65 phosphoregulated protein with an N-terminal dimeric coiled-coil (DCC), assembles into a hexameric ar
67 is due to the architecture of the extracted dimeric complex, with all the polarity located within th
69 ii) SQDG has a major role in stabilizing the dimeric complex; (iii) the b (6) f complex is stabilized
70 rmed as well, which suggests the role of the dimeric complexes in the low-temperature NH(3)-SCR react
72 A) precursors was used to inform design of a dimeric compound (2) selective for one of the miRNAs.
77 In the structure, RctB adopts a head-to-head dimeric configuration that likely reflects the arrangeme
79 C(N1437H) was found to be locked in a stable dimeric conformation in solution and its GTPase activity
80 shifting the equilibrium toward the active, dimeric conformation, thus priming BRAF(D594G) as an eff
81 (EREG) and epigen (EPGN) stabilize different dimeric conformations of the EGFR extracellular region.
82 LRRK2 G-domain cycles between monomeric and dimeric conformations upon binding to GTP or guanosine d
83 e in which a pair of ISD11 subunits form the dimeric core of the SDA complex, which clarifies the cri
84 ts are structurally homogeneous, and adopt a dimeric core, where the third repeats of two tau molecul
85 s model is used to predict new monomeric and dimeric CP derivatives with solubilities of >1 M in acet
86 present and active for methane oxidation, a dimeric Cu motif is the primary active site for selectiv
87 type form or E locked in a covalently linked dimeric (cvD) conformation to enhance the exposure of E
89 ectron microscopy (cryo-EM) structure of the dimeric cytb(6) f complex from spinach, which reveals th
91 assemble with one joining-chain (JC) to form dimeric (d) IgA that is bound by the polymeric Ig-recept
93 nulocyte colony-stimulating factor GCSF homo-dimeric derivatives linked by differed by linkers of dif
94 three different recombinant GCSF-based homo-dimeric derivatives were evaluated by total internal ref
95 the engineering of a series of monomeric and dimeric designed ankyrin repeat proteins (DARPins) for t
99 4 long isoforms endogenously, and requires a dimeric enzyme assembly, as adopted by long, but not by
101 We report on the transition of FICD from a dimeric enzyme, that deAMPylates BiP, to a monomer with
104 on versus structural changes) for PT and its dimeric equivalent PD on the basis of the rate and activ
107 In agreement with the crystal structure, dimeric Fab HC84.26.5D is able to bind two HCV E2 molecu
108 strate that the highly identifiable shape of dimeric Fab HC84.26.5D makes it useful as a fiducial mar
109 120 is required for interaction with soluble dimeric FcgammaRIIIa in enzyme-linked immunosorbent assa
110 proteins with C2 symmetry-a de novo designed dimeric ferredoxin fold and a de novo designed TIM barre
111 atomic resolution, we observed that it is a dimeric flavocytochrome with an unusually close interact
112 ired for the catalytic activity and that the dimeric form of ATPase-CW might cooperatively bind to ds
114 onverts phosphoenolpyruvate to pyruvate, the dimeric form of PKM2 has alternative, nonglycolysis func
118 as metastable species in equilibrium with a dimeric form, usually a spin-paired sigma dimer or a pi
121 orms were used as compared with monomeric or dimeric forms, we investigated the extent to which trime
122 These analyses revealed that SYCE3 adopts a dimeric four-helical bundle structure that acts as the b
123 r and dimer, indicating that physiologically dimeric fraction is important and might be necessary for
126 etabotropic glutamate receptors (mGluRs) are dimeric G-protein-coupled receptors that operate at syna
128 c GH-C53S is 25.2% of that of GH-WT and that dimeric GH-C53S-His has no significant bioactivity in ce
129 ination shows that the FIP200 CTR contains a dimeric globular domain that we designated the "Claw" fo
131 induced UPR is triggered by bacterial cyclic dimeric GMP, in a STING-dependent manner, and that this
133 the intracellular secondary messenger cyclic dimeric-GMP (c-di-GMP) in response to environmental cond
134 we investigate synchronous stimulation of a dimeric GPCR, the metabotropic glutamate receptor type 1
135 ted by the bacterial second messenger cyclic dimeric guanosine monophosphate (c-di-GMP) by posttransc
137 ndary messenger c-di-GMP (Bis-(3'-5')-cyclic dimeric guanosine monophosphate), to make a vital choice
139 ee Xenopus laevis egg extract identified the dimeric histone chaperone facilitates chromatin transcri
140 ic PSII as well as a significant fraction of dimeric holocomplexes that identify this membrane area a
144 udy, we present the solution conformation of dimeric human OAS2 using an integrated approach involvin
145 Mutations in the GUCY2D gene coding for the dimeric human retinal membrane guanylyl cyclase (RetGC)
148 ype I mucosa (such as the intestinal tract), dimeric IgA secreted by local plasma cells is transporte
151 hat whereas the isolated WT globin domain is dimeric in solution, the Y15A and Y15G variants in which
154 tion, we present the structure of the entire dimeric insulin receptor ectodomain saturated with four
157 his reactivity, including the formation of a dimeric intermediate, interconversion between ground- an
158 hion with racemization of a Cu(I) homochiral dimeric intermediate, reducing the stereoselectivity of
159 lated, heterogeneous, and locally disordered dimeric intermediates along the dimer dissociation pathw
160 ell-defined and readily available air-stable dimeric iridium(III) complex catalyzed alpha-alkylation
161 al and spectroscopic characterization of the dimeric iron hydride complex [Ph(2)B((t)BuIm)(2)FeH](2)
162 or the development of drugs to stabilize the dimeric LC structure and hence prevent LC amyloidosis.
164 an engineered form of sTie2, which presents dimeric ligand binding sites, inhibits Angpt1 signalling
165 choline receptor (MR) antagonists, including dimeric ligands, were prepared using red-emitting cyanin
167 ar dynamics simulations for 69 monomeric and dimeric lignin-related phenolics with 3 model membranes
169 r this purpose, we employ synTacs, which are dimeric major histocompatibility molecule scaffolds of d
170 folding from partially folded monomeric and dimeric MC subunits (in chloroform) up to the full penta
172 0-step total synthesis of (-)-curvulamine, a dimeric member with promising Gram-positive and -negativ
173 as well as fusion proteins of monomeric and dimeric membrane proteins as reference structures, and w
174 ting in opposition as logic would suggest, a dimeric methyltransferase and monomeric demethylase coop
175 ese peptides and macrocycles, along with the dimeric model of LDH-H, constitute promising pharmacolog
176 l dynamics are essential for function of the dimeric molecular chaperone heat shock protein 90 (Hsp90
181 or acetylated, which initiates a switch to a dimeric/monomeric form that translocates into the nucleu
183 itro and cellular assays to directly compare dimeric motors across the kinesin-1, -2, and -3 families
184 nd force output by monomeric motors, but not dimeric motors, are significantly decreased by the addit
185 nomeric unprocessed proMPO versus the mature dimeric MPO and the functional role of the propeptide.
186 XS) analyses of recombinant disulfide-linked dimeric MUC5B dimerization domain we identified an asymm
192 e document PCR amplification of DNA with two dimeric nucleotides, and show that the dimers can promot
194 recombinant DDR2 ECD proteins in monomeric, dimeric or oligomeric state, and MC3T3-E1 cells expressi
195 is reported based on isopeptide-N-ethylated dimeric or polymeric Ub chains, which can be efficiently
196 own galectins in mammalian cells, which have dimeric or tandem-repeated CRDs enabling multivalency fo
197 mical analyses demonstrated that the unusual dimeric organization stabilizes the active site, facilit
201 PaParE toxin is monomeric and interacts with dimeric PaParD antitoxin with a K(D) in the lower picomo
202 c acetoxylation product and formation of the dimeric Pd(I) complex [Pd(I)(DAF)(OAc)](2), followed by
203 uptake of alpha(v)beta(3)-selective cyclic, dimeric peptide (68)Ga-DOTA-E[c(RGDfK)](2), where E[c(RG
205 MARV VP40 (mVP40) has been shown to be a dimeric peripheral protein with a broad and flat basic s
208 in CsANRa transgenic flower extracts formed dimeric procyanidin B1 or B2, demonstrating the role of
209 tion mode dataset showed trimeric and A-type dimeric procyanidins, and caffeoylshikimic acid as main
210 bserved in a reducing environment with these dimeric prodrugs, with the superior leaving group promot
212 trans-1-bromo-2-methoxycyclooctane provides dimeric products consistent with fleeting cycloocta-1,2-
215 shown that the CO-bound ferrous form of the dimeric protein absorbed at 448 nm (catalytically compet
216 SP_0782 from Streptococcus pneumoniae is a dimeric protein that potentially binds with single-stran
217 spectroscopy, and for the large, multidomain dimeric protein von Willebrand factor (VWF) that is crit
219 twork that responds to a membrane-associated dimeric protein with the uncaging of a powerful cytotoxi
220 tive cooperative binding of inhibitor to the dimeric protein, driven by favorable entropic contributi
222 ia coli, and in mammalian cells to crosslink dimeric proteins and endogenous membrane receptors.
224 supported by GST-PX or GST-FYVE, recombinant dimeric proteins which tether by binding the phosphoinos
225 The structure reveals interactions of the dimeric pseudonuclease core of TEFM with mobile structur
228 few ligands have been reported that bind to dimeric quadruplexes, but their preclinical pharmacologi
230 structures show that the transporter forms a dimeric RagA(2)B(2) complex, with the RagB substrate-bin
232 eceptor ephrinB2 and show that monomeric and dimeric receptors activate distinct conformational chang
236 This structural and functional asymmetry of dimeric RING finger domains may be a general feature of
237 HelD abundance during slow growth and a dimeric (RNAP-delta-HelD)(2) structure that resembles hi
238 t with DNA as the cause of cell death, while dimeric Ru(ii) polypyridyl complexes are classified acco
242 proach to create a family of self-assembling dimeric sensors that we call DimerDyes and its use for t
246 opulation of the off-pathway (nonproductive) dimeric species largely unaffected (tau(ex) ~750 mus).
248 STING from human and chicken in the inactive dimeric state (about 80 kDa in size), as well as cGAMP-b
249 n equilibrium between a high-populated (98%) dimeric state and a low-populated (2%) monomeric state.
250 with rogue chaperone activity, stabilizing a dimeric state and transporting TpoR and mutants thereof
257 s suggest the interplay between monomeric vs dimeric states has a hereto unappreciated role in semaph
258 orts to engineer a (monovalent) single-chain dimeric streptavidin (scdSav) as scaffold for Sav-based
260 r work presents the first, to our knowledge, dimeric structural models of OAS2 that enhance our under
262 h the arm domain in the other monomer in the dimeric structure (i.e. the prodomain arm domain and GF
266 ide dismutases (Cu, Zn-SODs) showed that the dimeric structure contributed to the high catalytic effi
268 l-molecule kinetic stabilizers of the native dimeric structure of full-length LCs, which can slow or
269 teraction interface on the three-dimensional dimeric structure of the N-terminal domain of the MERS-C
273 nk the monomeric complexes together into the dimeric structures and provide a pivot to allow the mono
274 hylalkyne-derived substrates gave unexpected dimeric structures in good yield with excellent enantios
280 etermine the atomic resolution structures of dimeric, tetrameric, and pentameric IgA-Fc linked by the
281 an ADM-based mixture model for monomeric and dimeric TF-binding motifs and an expectation maximizatio
283 tetrameric complex is essentially a dimer of dimeric TOM, which may be capable of forming higher-orde
288 of designed analogues possessing monomeric, dimeric, trimeric, and tetrameric macrocyclic lactones c
289 along wild-type MT is performed in steps of dimeric tubulin, the removal of the tails results in a s
292 losterically disrupt or stabilize the active dimeric unit, accordingly inhibiting or stimulating RNas
293 e generated a model for UVR8 action in which dimeric UVR8 rapidly monomerises in response to UV-B exp
294 res of Evasin-4 and E66S CCL5, an obligatory dimeric variant of CCL5, were determined to a resolution
296 nucleoprotein complex (vRNP) consisting of a dimeric viral genome and associated proteins, together c
297 t with our previous hypothesis that specific dimeric viral RNA-Gag interactions are the nucleation ev
299 and X-ray scattering indicated that FHR5 was dimeric, with a radius of gyration (R(g) ) of 5.5 +/- 0.