ライフサイエンスコーパス: dimerization

1 enation of halothiophenes, or electrophilic "dimerization".

2 or kinase domain was important to potentiate dimerization.

3 mechanism of cGAS entails dsDNA-binding and dimerization.

4 und EGFR kinase activity to be essential for dimerization.

5 imerization, which can be facilitated by Ras dimerization.

6 develop inhibitors that can disrupt the KRAS dimerization.

7 tes a unique C-terminal tail of MlaF in self-dimerization.

8 hesized that phosphorylation could influence dimerization.

9 lecular parameters lead to sigma- versus pai-dimerization.

10 at can directly bind to and inhibit survivin dimerization.

11 in both this tension and the globin domain's dimerization.

12 TLR9 activation occurs via its dimerization.

13 flAPP interaction with BACE1 and enhance APP dimerization.

14 ween two anions is expected to prevent their dimerization.

15 e examined through indirect evidences of Ras dimerization.

16 terface of kinase domains in regulating EGFR dimerization.

17 relayed to binding sites that allow for rev dimerization.

18 ucing ligand affinity or disrupting receptor dimerization.

19 main that has an established role in protein dimerization.

20 c and becomes part of the interface upon Raf dimerization.

21 p90 protomers prior to ATP-directed N-domain dimerization.

22 LR4-MD-2 complex formation and TLR4-MD-2-LPS dimerization.

23 a chimeric receptor likely to have impaired dimerization.

24 ng of IT1t to this variant promotes receptor dimerization.

25 and induces global conformational change and dimerization.

26 rapid motions in the region responsible for dimerization.

27 -site residues play in guiding selective DKP dimerization.

28 nt in coordinating cavity collapse with LptB dimerization.

29 another mechanism that does not involve Ras dimerization.

30 ommon activation mechanisms of CARD-mediated dimerization.

31 u coordination environment that enhances C-C dimerization.

32 sphorylation of IRF3 Ser386, to achieve IRF3 dimerization.

33 tion by lowering the apparent barrier for CO dimerization.

34 kinase-mediated tyrosine phosphorylation and dimerization(3,4).

35 tations that disrupt either trimerization or dimerization abolish ligand-induced receptor activation.

36 Here, we analyzed how SERCA2a dimerization affects ER Ca(2+) transport.

37 This indicates that differential B-class dimerization affects protein degradation, revealing an i

38 ly enthalpically driven, resulting in higher dimerization affinity than the CA-domain dimer.

39 ace in a syn-precursor structure followed by dimerization after triplet excitation.

40 Dimerization allows kinesins to be processive motors, ta

41 Differential dimerization also affected B-class complex composition a

42 oved CAR design which enables controlled CAR dimerization and (ii) a significant reduction of antigen

43 mbrane regions of TRKA play key roles in its dimerization and activation by NGF.

44 We show that FGF23-WT stimulates dimerization and activation of a chimeric receptor molec

45 ed inner and peripheral rings, that prevents dimerization and activation of the catalytic domains.

46 Structural data point to a common dimerization and activation path for TpoR via its TM dom

47 ST3GAL1 induces AXL dimerization and activation that, in turn, promotes mela

48 T1-mediated K337 acetylation, leading to ME1 dimerization and activation, both of which are reversed

49 nantio- and diastereoselective NHC-catalyzed dimerization and an amidation/N-acyliminium ion cyclizat

50 be regulated through competition between APP dimerization and APP cholesterol binding.

51 Additionally, statin-induced changes in APP dimerization and APP-BACE1 are dependent on cholesterol

52 (ie, NTRK3L449F) domains increased receptor dimerization and cell-surface abundance.

53 eously bound to two alpha4 tails, leading to dimerization and clustering of alpha4 integrins on the c

54 We also introduce PIN dimerization and describe an effect of NPA on this, sugg

55 tion, and then carry out analyses of insulin dimerization and dissociation using atomistic molecular-

56 method on the AP-1 transcription factor, the dimerization and DNA binding behavior of retinoic acid r

57 e the (R)RNPP-type ComR sensor by triggering dimerization and DNA binding.

58 crystal surface, where it is complemented by dimerization and expedites dimer incorporation into grow

59 intermolecular disulfide bond that promotes dimerization and fibrillization.

60 ed time-dependent transient dynamics of EGFR dimerization and found EGFR kinase activity to be essent

61 identified as potential suppressors of OLIG2 dimerization and found to inhibit tumor growth in a mous

62 ssess the impact of the mutations on K-Ras4B dimerization and function.

63 terminal zinc finger domain enhances HDA15HD dimerization and increases its enzymatic activity.

64 show that interfaces responsible for initial dimerization and membrane attachment are essential for F

65 Protein dimerization and oligomerization are essential to most c

66 ess unfolded proteins in the ER lumen induce dimerization and oligomerization of IRE1, triggering kin

67 TP binding by lowering the threshold for RAF dimerization and pathway activation.

68 dual receptor subunits showed ligand-induced dimerization and revealed that the associated Janus kina

69 l-based assays, including chemically induced dimerization and single-molecule pulldown, we revealed t

70 transform into nanofibrils that disrupt HER2 dimerization and subsequent downstream signalling events

71 N-terminal domain (NTD) surfaces involved in dimerization and synapse assembly.

72 n the latch domain negatively regulated EGFR dimerization and the downstream signals.

73 ylides are privileged by higher barriers for dimerization and thus are readily intercepted by dipolar

74 rminus of the HigA antitoxin is required for dimerization and transcriptional repression.

75 ination of TSC1, thereby promoting TSC1-TSC2 dimerization and TSC2 stabilization.

76 , the precipitation of elemental sulfur, S-S dimerization, and especially through the formation of el

77 vents that involves primer annealing, genome dimerization, and virion assembly.

78 etal muscle proteins that associate with the dimerization- and DNA-binding domain of ATF4 (the bZIP d

79 repurposed or become inaccessible, and cGAS dimerization, another prerequisite for activation, is in

80 anisms and RNA binding surfaces, whereas the dimerization appeared to compromise catalytic activity.

81 se models, we developed a chemically induced dimerization approach to induce de novo APB condensation

82 Our findings introduce a chemical dimerization approach to manipulate phase separation and

83 The 2 mutated cysteines implicated in D3 dimerization are buried, providing a mechanism for prote

84 XR heterodimerization, and chromatin binding/dimerization are positively correlated.

85 clash of an ENZ-specific tyrosine within the dimerization arm, rationalizing why PRO is required to c

86 ical data, we quantify the free energy of Pd dimerization as <-4.5 kcal/mol for Pd(2)(II,III) and <-9

87 The SOMC methodology prevents undesired dimerization as encountered in solution and leading to a

88 RDM1 dimerization at the center frames the assembly of the en

89 We propose that dimerization attenuates the autoubiquitination-induced t

90 We evaluated the divergent dimerization behavior by measuring the strength of each

91 are also reported, showing retention of the dimerization behavior in this scaffold.

92 e in the dimerization behavior: (1) that the dimerization behavior is dictated by radical spin densit

93 hypotheses to explain the difference in the dimerization behavior: (1) that the dimerization behavio

94 Remarkably, "cross"-dimerization between GTP- and GDP-bound KRAS molecules i

95 cific HER2 targeting, and inhibition of HER2 dimerization blocks the expression of proliferation and

96 the CC3 interface is not required for Atg11 dimerization but is required for shaping Atg32 into func

97 terface K101D/R102E double mutations reduced dimerization but only slightly reduced downstream phosph

98 that the signaling lipid PIP(2) promotes TM dimerization, but only in the small crossing angle state

99 Dimerization can be repeatedly restored with uncleaved z

100 In this study, we used chemically inducible dimerization (CID) assays in tandem with CRISPR KO lines

101 Chemically inducible dimerization (CID) uses a small molecule to induce bindi

102 The dimerization constant of MB and the quantum efficiency o

103 te-supported catalyst selective for ethylene dimerization; correspondingly, the catalyst on the SAPO

104 nce complementation assays demonstrated that dimerization-defective Nef mutants retained interaction

105 on incorporation of SERINC5 was increased by dimerization-defective Nef mutants, whereas down-regulat

106 onsistent with this mechanism, we found that dimerization-deficient UBE2S turned over more rapidly in

107 ed us to predict the general position of the Dimerization/Docking (D/D) domain, which is essential fo

108 that interacts with clients and a C-terminal dimerization domain (C).

109 The Diaphanous inhibitory domain-dimerization domain (DID-DD) region of Dia1 was sufficie

110 chimera between the AP20187-inducible F(V)2E dimerization domain and the cytosolic protein tyrosine k

111 at the elbow brings into proximity the hinge dimerization domain and the head-kleisin module, situate

112 imerization interface and in residues of the dimerization domain exposed to lipids.

113 at 2.20 angstrom resolution, which reveals a dimerization domain inserted into an N-terminal ABC ATPa

114 veral atypical features, such as an extended dimerization domain of CheA and a variant CheW-CheR-like

115 found that Sgo1 interacts directly with the dimerization domain of the CPC subunit Borealin.

116 ain of one TBK1 subunit and the scaffold and dimerization domain of the second subunit in the TBK1 di

117 vitro The CORD6 mutation R838S in the RetGC1 dimerization domain strongly dominated the Ca(2+) sensit

118 struct that encodes the Lhx2-HD and Ldb1-DD (dimerization domain) in a single transcript cell-autonom

119 CASFx) using the FKBP-FRB chemical-inducible dimerization domain, allowing small molecule control of

120 lows the structural conservation of the TRIM dimerization domain, observed in other proteins.

121 ibed, but less is known about its C-terminal dimerization domain.

122 aused by the high sequence similarity in the dimerization domains, we modify the codons for mouse gen

123 Here we show that, in HD, ATAD3A dimerization due to deacetylation at K135 residue is req

124 results reveal how ligand-regulated receptor dimerization dynamics and adaptor protein concentrations

125 PRC2 dimerization enhances CGI DNA binding by PCLs in pairs i

126 specificity allows for tunable modulation of dimerization equilibrium.

127 AR dimerization follows a unique head-to-head and tail-to-t

128 as attributable to the changes in gramicidin dimerization free energy by drug-induced perturbations o

129 e transient molecules and their tendency for dimerization, free carbenes represent one of the foremos

130 uishes an activation mechanism involving Ras dimerization from another mechanism that does not involv

131 A3G dimerization generates a surface with intensified positi

132 KRAS homo-dimerization has been implicated in the activation of RA

133 c loop located at the tip of two amphipathic dimerization helices.

134 ive JAK2 mutants promoted ligand-independent dimerization, highlighting the formation of receptor dim

135 teins are prominent in biology, and receptor dimerization (homo- or heterodimerization) is central to

136 -like domain (ULD) or SDD display defects in dimerization; however, a subset retains kinase activity.

137 circumstantial evidences supporting the Ras dimerization hypothesis, direct proof of Ras dimerizatio

138 A structural perspective of the DIF, how dimerization impacts inhibitor activation and the struct

139 Loss of PRC2 dimerization impairs histone H3K27 trimethylation (H3K27

140 idespread phenomenon of transcription factor dimerization in active transcription.

141 ter KCC2, but rather with inhibition of KCC2 dimerization in differentiating neurons.

142 yrene maleic acid lipid particles to measure dimerization in membranes.

143 e the importance of ligand-independent TNFR1 dimerization in NF-kappaB signaling.

144 ew focuses on the implications of RAF kinase dimerization in signal transduction and for drug develop

145 isruption of the Ig1-Ig1 interface abolishes dimerization in solution.

146 mbrane and causes its thinning through trans-dimerization in the dark, resulting in an increased memb

147 rdering transition that is concurrent with a dimerization in the iron chains and a following formatio

148 T of fluorescent proteins as an indicator of dimerization, in which its signature consists of a very

149 ain antibody) that interferes with FluPol(A) dimerization inhibits the synthesis of vRNA and, consequ

150 observations suggest that Ca(2+) changes the dimerization interaction between MICU1 and MICU2, which

151 A dimerization interaction between SAS-6 N-terminal "head"

152 ntly, we used a novel approach to target the dimerization interface and identified inhibitors of two

153 he movable core domain, but also in the core-dimerization interface and in residues of the dimerizati

154 We identified a highly conserved ADAR dimerization interface and validated the importance of t

155 utic efficacy of targeting the alpha4-alpha5 dimerization interface as an approach to inhibit RAS-dri

156 h protein is preserved via the kinase domain dimerization interface in all variants, full-length AfGc

157 investigated the role of the globin domain's dimerization interface in signal transduction in AfGcHK.

158 We also show that mutation in the dimerization interface inhibits editing in an RNA substr

159 gamma signaling, potentially by disrupting a dimerization interface on JH2.

160 xpressing Nef variants with mutations in the dimerization interface replicated poorly and were signif

161 ions of CXCR4 residues located at a putative dimerization interface result in monomerization of the r

162 rs rotate relative to each other, yielding a dimerization interface with more inter-subunit interacti

163 e copper (Cu(2+)) binding site at the H3-H3' dimerization interface with unknown function.

164 the SMC hinge, which serves as rather stable dimerization interface.

165 teric modulator binding at the transmembrane dimerization interface.

166 15 modifications occur at catalytic sites or dimerization interfaces of enzymes.

167 eins into filaments that are cross-linked by dimerization into dynamic three-dimensional molecular co

168 al transduction mechanisms indicate that RAF dimerization is a critical step in multiple cellular con

169 r that precludes receptor dimerization; such dimerization is a prerequisite for proinflammatory signa

170 obin domain of AfGcHK and that globin domain dimerization is essential for internal signal transducti

171 The dimerization is facilitated by unmethylated cytosine-pho

172 r strategy based on cucurbit[8]uril-directed dimerization is further applied to generate hetero-chrom

173 lar, meaning that the co-operative effect of dimerization is made explicit by evaluating the differen

174 Dimerization is mediated entirely by deletion of a singl

175 It has been hypothesized that Ras dimerization is necessary to create activated Raf dimers

176 We conclude that dimerization is not necessary but enhances downstream MA

177 Our structural data also suggest that this dimerization is required for maintaining G(N) structural

178 -swapped dimer in cells and demonstrate that dimerization is reversible.

179 dimerization hypothesis, direct proof of Ras dimerization is still inconclusive.

180 Dimerization is stimulated by the lysine-rich carboxyl-t

181 Ligand-induced dimerization is the predominant mechanism through which

182 conclusion and found that telopeptide aldol dimerization is the primary mechanism for stable cross-l

183 Ribosome dimerization is thought to be reversible, with the disso

184 ha5, which has been proposed to mediate KRAS dimerization, is accessible only in state B.

185 ly, SHOC2 deletion prevents MEKi-induced RAF dimerization, leading to more potent and durable ERK pat

186 eses for receptor activation: ligand-induced dimerization, ligand-induced rotation, and receptor clus

187 ne, these alkaloids were fashioned through a dimerization, macrocyclization, and four consecutive red

188 Further, the differential kinetics on this dimerization mechanism underlie an intricate gene regula

189 que A3G variants were solved which suggested dimerization mechanisms and RNA binding surfaces, wherea

190 ptors to better understand specific receptor dimerization mechanisms.

191 Dimerization, membrane association, and VASP binding are

192 aling candidates for control via optogenetic dimerization methods.

193 The mechanism PIP(2) uses to promote dimerization might involve alleviating this repulsion du

194 of isavuconazole against A. castellanii The dimerization mode observed in this work is compatible wi

195 lead to improved forecasts of sigma- vs pai-dimerization mode, and suggest that a balance of spin de

196 A dimerization model is proposed to account for binary int

197 CIB), a blue light-activated protein-protein dimerization module from the plant Arabidopsis thaliana,

198 Thus, the TIG domain is a promiscuous dimerization module that has been appropriated for a ran

199 unknown how CD1/CD2 domains connect and how dimerization/multimerization is linked to RNA binding an

200 ield, we have also determined precisely when dimerization occurs.

201 ed via NaH/Ac(2)O-mediated dearylacetylative dimerization of 2-arylacetyl-1-naphthols in refluxing TH

202 Dimerization of 3-substituted 2-oxindoles has been devel

203 llylations under transition metal catalysis, dimerization of acetylenes, bromination of benzylic subs

204 f a library of molecules, derived by electro-dimerization of arylpyridiniums(11), adsorbed on copper.

205 In this study, we show that indirect dimerization of BCAP TIR is required for negative regula

206 Both homo- and hetero-dimerization of BRAF and CRAF can modulate therapeutic r

207 escently labeled SERCA2a revealed increasing dimerization of Ca(2+) pumps with increasing expression

208 le-stranded DNA (dsDNA), with AcrVA4 driving dimerization of Cas12a.

209 hes" to reversibly regulate the activity and dimerization of FN3K.

210 3 catalyzed the prebiotically relevant aldol dimerization of glycolaldehyde to give threose and eryth

211 Dimerization of HER2 receptors leads to the activation o

212 We then use FRET to analyze the dimerization of human rhomboid protease RHBDL2 in giant

213 Without alcohol, self-dimerization of isatins gives rise to tryptanthrin and i

214 readily be produced from the dehydration and dimerization of isobutanol, produced from the fermentati

215 xhibits a good catalytic performance for the dimerization of isobutene (2-methyl-1-propene), and achi

216 ith a unique role in cell motility driven by dimerization of its pseudokinase domain.

217 Dimerization of KRAS-GTP, stabilized by electrostatic in

218 an L1-FnIII-2 interaction that mediates the dimerization of membrane-proximal domains of IGF1R.

219 otif that dictates the membrane topology and dimerization of MRAP1 does not control the membrane orie

220 oes not control the membrane orientation and dimerization of MRAP2.

221 ective and scalable two-step approach to the dimerization of norbornadiene (NBD) into its thermodynam

222 monstrated that this interaction impeded the dimerization of P protein and thus suppressed RABV repli

223 phoprotein (P protein) and thus blocking the dimerization of P protein.

224 king points are created by the photo-induced dimerization of pendant anthracene groups.

225 Electrochemical generation and selective dimerization of persistent radicals is followed by therm

226 ce that have been applied to the analysis of dimerization of single-spanning membrane proteins.

227 py, we observe large structural changes upon dimerization of TDP-43.

228 omain and a coiled-coil region to facilitate dimerization of the 90 amino acid polypeptide.

229 ich allows reconstitution of AJs by chemical dimerization of the force bearing structures and their p

230 Additionally, we found that although the dimerization of the full-length protein is preserved via

231 indicate that Tyr-15 plays a key role in the dimerization of the globin domain of AfGcHK and that glo

232 action between two HAT units is mediated via dimerization of the heavy chain subunits and does not in

233 that would be incompatible with back-to-back dimerization of the IRE1alpha protein and activation of

234 n this study, we show that sequence-specific dimerization of the p24 transmembrane helix is mediated

235 ty: the PUM-HD dictates binding to UAAU, and dimerization of the RRM domain favors binding to dual UA

236 Solution- and solid-state studies of the dimerization of this new congener to the P-phenoxy varia

237 We quantified the dimerization of three prototypic class I cytokine recept

238 rnative NLRP3 inflammasome via caspase-8 and dimerization of Toll-like receptors 2 and 4.

239 e showed that L498W and H499C strongly drive dimerization of TpoR.

240 f the TRKA transmembrane domain (TMD) in the dimerization of TRKA and the structural details of the T

241 y, some gem-disubstituted cyclopropenes give dimerizations of the intermediate carbene.

242 We developed a system to study KRAS dimerization on nanodiscs using paramagnetic relaxation

243 le many diverse folds and motifs can mediate dimerization, only two structurally distinct domains hav

244 cally control erythropoietin receptor (EpoR) dimerization orientation and distance between monomers.

245 nd 23 TPs were characterized, resulting from dimerization, oxygenation, cleavage, cleavage combined w

246 s light on how NgBR stabilizes DHDDS through dimerization, participates in the enzyme's active site t

247 ts own promoter or ectopically together with DIMERIZATION PARTNER A, further elevate the amount of th

248 tions, the structures also revealed how FUT8 dimerization plays an important role in defining the acc

249 mutation-derived BRAF variants, has a higher dimerization potential as compared with WT BRAF.

250 Mutation to disrupt dimerization prevents nucleolar localisation of PiSFI3 a

251 The Jun dimerization protein 2 (Jdp2) is expressed predominantly

252 MNT also binds to the MAX dimerization protein MLX (MLX), and MNT-MLX and MNT-MAX

253 Light-inducible dimerization protein modules enable precise temporal and

254 This concentration-dependent dimerization provided means of comparison of the functio

255 Dimerization quality control further improves proteostas

256 sight into target selection by SCF-FBXL17, a dimerization-quality-control E3 ligase that ubiquitylate

257 ing constituents and, (ii) by decreasing the dimerization rate.

258 ligand bond formation drives the critical Pd dimerization reaction in between electrochemical oxidati

259 These data suggest that SERCA2a dimerization regulates Ca(2+) transport by improving bot

260 ver, the functional significance of the pump dimerization remains unclear.

261 D3 dimerization requires co-association with D1 and D2, Ca(

262 Suppressors of defective dimerization restore ab initio formation of UapA dimers

263 In contrast, differential dimerization resulted in large-scale changes to downstre

264 While the dimerization scenario exhibits robust behavior, the acti

265 onance spectroscopy, determining the mode of dimerization (sigma- or pai-dimer) by UV-vis spectroscop

266 dies indicated a mechanism of Zn(2+)-induced dimerization similar to smaller constructs; however, Brp

267 nd from this family binds at the head domain dimerization site of algae, nematode, and human SAS-6 va

268 ins are directly transmitted to the kindlin2 dimerization site, resulting in a shift in an R577-S550/

269 nteractions with a hydrophobic cavity at the dimerization site.

270 l catalytic activity, dsDNA length-dependent dimerization specifically accelerates the cyclization of

271 , their binding depends on the ATP-dependent dimerization state of FlhG.

272 of TLR4 in a manner that precludes receptor dimerization; such dimerization is a prerequisite for pr

273 as a circularly permuted rapamycin-inducible dimerization system composed of the canonical FK506-bind

274 We find using the CIBN-CRY2 optogenetic dimerization system that the phosphoryl group positioned

275 TLR2 trans-membrane peptide that blocks TLR2 dimerization that is critical for TLR2/1 and TLR2/6 hete

276 0), including transient, ATP-biased N-domain dimerization that is necessary to attain ATPase competen

277 K42D double mutations did not interfere with dimerization, they almost completely blocked K-Ras4B-med

278 ec and Itk, which we show are not capable of dimerization through their PH-TH modules.

279 le at higher temperatures, near quantitative dimerization to form a molecular cage is observed.Howeve

280 to Ru(III), they undergo facile, on-surface dimerization to give surface-bound, oxo-bridged dimers.

281 improve PA-Cre technology, we compare light-dimerization tools and optimize for mammalian expression

282 ism of action, we undertook a study of OLIG2 dimerization using fluorescence cross-correlation spectr

283 We also demonstrate OAS2 dimerization using immunoprecipitation approaches in hum

284 ene system at 350 nm results in quantitative dimerization via [2 + 2] cycloaddition to form a [3]-lad

285 ), but the desired (PAlP)Rh(CO)(2) underwent dimerization via isocarbonyl bridging.

286 We found that differential B-class dimerization was associated with subtle, quantitative di

287 sibility of tyrosine phosphorylation-induced dimerization, we excluded this possibility by using smal

288 For the dimerization, we reconstitute acto-myosin connection of

289 To gain insight into the different modes of dimerization, we synthesized and evaluated a library of

290 The ZF contributes to protein dimerization when the LZ coiled-coil is intact, but it i

291 bind Raf; however, Raf's activation requires dimerization, which can be facilitated by Ras dimerizati

292 activation mediated by intracellular kinase dimerization, which is structurally accommodated by addi

293 e C-terminal motif of NUBP1 promotes protein dimerization, while cluster binding to the N-terminal mo

294 enabling high spatiotemporal confinement of dimerization with a single excitation wavelength.

295 Chalcones were found to undergo sulfurative dimerization with elemental sulfur to tetrasubstituted 1

296 tation that disrupts PT2385 binding, but not dimerization with HIF-1beta, did not respond to PT2385,

297 TMO5 evolved its modern function, including dimerization with LHW, at the origin of land plants.

298 epertoire of TFAP2A targets depends upon its dimerization with paralogous proteins TFAP2C and TFAP2B.

299 ith Oct6 and an Oct4 mutant defective in the dimerization with Sox2 (Oct4(defSox2)).

300 tic analysis of the interactions involved in dimerization yielded a mechanistic blueprint for homodim