ライフサイエンスコーパス: dimerization interface

1 the core domain, some 20 degrees against the dimerization interface.

2 smembrane helix 4 (TM4) provides the primary dimerization interface.

3 unknown function that appears to extend the dimerization interface.

4 residues strategically positioned within the dimerization interface.

5 ar relevance to drug binding and part of the dimerization interface.

6 n of charged residues in the hydrophobic BAR-dimerization interface.

7 ting through specific surface charges at the dimerization interface.

8 s of Glu50 and Arg64 residues located on the dimerization interface.

9 ture in a heptapeptide strand that forms the dimerization interface.

10 e MD-2/TLR4 interaction surface opposite the dimerization interface.

11 Site 2 metal binding sites are formed at the dimerization interface.

12 e, and this requires the predicted Cse4-Cse4 dimerization interface.

13 t human, TLR4 (Lys(367) and Arg(434)) at the dimerization interface.

14 ry structure of the homodimer, affecting the dimerization interface.

15 n interaction is trans, where it adds to the dimerization interface.

16 appears to brace the principal helix of the dimerization interface.

17 res of the Puf1 RRM domain that identified a dimerization interface.

18 ut reveals an unexpected twist and a complex dimerization interface.

19 ing pocket and had allosteric effects on the dimerization interface.

20 teric modulator binding at the transmembrane dimerization interface.

21 the hormone-binding site or the amino domain dimerization interface.

22 eric transporter that binds substrate at the dimerization interface.

23 thetic binding pocket within an interhelical dimerization interface.

24 n the two antiparallel alpha6 helices at the dimerization interface.

25 that likely involves occlusion of the H3-H3 dimerization interface.

26 oiled coil domain that serves as its primary dimerization interface.

27 esting that the C terminus forms part of the dimerization interface.

28 th the substrate-binding site as well as the dimerization interface.

29 /mol) being mediated by the mutations at the dimerization interface.

30 lly disrupted by single mutations in the RXR dimerization interface.

31 n variable fragment (scFv) that binds at the dimerization interface.

32 large domain rearrangement that exposes this dimerization interface.

33 ical active site capping domain and a unique dimerization interface.

34 itors aimed at binding to the monomer at the dimerization interface.

35 cture emerges of the C linker as a potential dimerization interface.

36 erminus of AR, which lies in a groove at the dimerization interface.

37 me face of an alpha-helix that constitutes a dimerization interface.

38 tracellular end, is likely to be part of the dimerization interface.

39 ed coil formed by two long helices along the dimerization interface.

40 at places the B7 binding sites distal to the dimerization interface.

41 the protein, and changes in residues in the dimerization interface.

42 the altered residues reside at the putative dimerization interface.

43 ever, is not uniformly distributed along the dimerization interface.

44 ressor may also be distinct from that of its dimerization interface.

45 o not touch the ligand-binding domain or the dimerization interface.

46 that requires conserved residues within the dimerization interface.

47 vealing unexpected dynamics at the HER2-HER3 dimerization interface.

48 made of four distinct domains and a flexible dimerization interface.

49 ons lie along their evolutionarily conserved dimerization interface.

50 by surface residues that face away from the dimerization interface.

51 istal surface away from the bound DNA as the dimerization interface.

52 dependent on disorder or variability in the dimerization interface.

53 ther VirB8 homologs but displayed an altered dimerization interface.

54 the SMC hinge, which serves as rather stable dimerization interface.

55 affinity to an extended hairpin loop at the dimerization interface.

56 IT acts on an allosteric site other than the dimerization interface.

57 hain of the AHL is in close proximity to the dimerization interfaces.

58 activity by structure-based targeting of the dimerization interfaces.

59 are stabilized by multiple, relatively weak dimerization interfaces.

60 A1 require two previously identified TIR-TIR dimerization interfaces.

61 omain-not from the intertwined nature of the dimerization interface; (2) residues 2-66 contain all of

62 the acyl pocket toward the four-helix bundle dimerization interface 25 A away.

63 ases involving three types of interface: the dimerization interface, a primary substrate-like interac

64 Mutations in the N-domain dimerization interface abolished assembly of nonphosphor

65 he ATPase domain by disrupting the off-state dimerization interface along the helical linker region b

66 ll molecule previously shown to bind the Nef dimerization interface also reduced Nef interactions wit

67 itution of Glu-106, which might be part of a dimerization interface, altered pH but not voltage modul

68 establish the stem region of MT6-MMP as the dimerization interface, an event whose outcome imparts p

69 ature activation: (1) cis blocking of the D4 dimerization interface and (2) trans interactions betwee

70 relaxation in other regions, including a PAS dimerization interface and a segment in the H-NOX domain

71 ins (LBDs), which reveals an unusually large dimerization interface and a small CAR ligand binding po

72 f KCC2 with variable anchoring points at the dimerization interface and an important C-ter extremity

73 tated residues that comprise the core of the dimerization interface and characterized the ability of

74 is shows that QsIA binding occupies the LasR dimerization interface and consequently disrupts LasR di

75 lution to re-engineer the serine recombinase dimerization interface and generate a recombinase archit

76 e beta and gamma subunits contributes to the dimerization interface and has been implicated in effect

77 ntly, we used a novel approach to target the dimerization interface and identified inhibitors of two

78 t this motif was buried within the channel's dimerization interface and identified two cytoplasmicall

79 he movable core domain, but also in the core-dimerization interface and in residues of the dimerizati

80 combination of computational analysis of the dimerization interface and in silico screening, we ident

81 ligand-binding pocket and at loops near the dimerization interface and interlobe hinge region.

82 nded enzyme propagate some 20 to 25 A to the dimerization interface and lead to a rearrangement of mo

83 ation inhibitors are usually targeted to the dimerization interface and need to compete with the attr

84 ved in previous studies due to the extensive dimerization interface and presence of lipopolysaccharid

85 rotein that is highly divergent in sequence, dimerization interface and protein fold.

86 R confirms the feasibility of a close-packed dimerization interface and suggests a possible solution

87 of BTN3A molecules identified as a possible dimerization interface and that is located close to the

88 s energy of stabilization is provided by the dimerization interface and that the isolated subunits ar

89 rbonate ions simultaneously bind to both the dimerization interface and the allosteric sites.

90 The protein-DNA contacts, the dimerization interface and the DNA curvature in the RXR-

91 We identified a highly conserved ADAR dimerization interface and validated the importance of t

92 ement (HRE), and is globally affected by the dimerization interfaces and interdomain interactions.

93 of these domains contributed residues to the dimerization interface, and competition experiments reve

94 at hinge opening starts from one side of the dimerization interface, and is coordinated by highly con

95 al amphipathic helix constitutes part of the dimerization interface, and similar N-terminal helices a

96 at the heme-proximal side, the globin domain-dimerization interface, and the ATP-binding site are imp

97 e the same Oct-1 residues that form the MORE dimerization interface are also used for OBF-1/Oct-1 int

98 s predicted to be the most disruptive at the dimerization interface are found to be less specific to

99 homodimer, and the residues involved in the dimerization interface are similar to those implicated i

100 d local 3-fold symmetry axes, and in CTD-CTD dimerization interfaces are less significant.

101 The data indicate that different dimerization interfaces are used for v-ErbA homodimeriza

102 ith retinoid X receptor alpha, and different dimerization interfaces are used on differently oriented

103 ation domain, but not those that involve the dimerization interface, are disrupted following ligand b

104 il to down-regulate CD4 and validate the Nef dimerization interface as a target site for antiretrovir

105 utic efficacy of targeting the alpha4-alpha5 dimerization interface as an approach to inhibit RAS-dri

106 op, which contains residue 225, could form a dimerization interface as was observed in the P450 2C8 c

107 Together with another dimerization interface at D1, a band-like one-dimensiona

108 Our results suggest for an Asn in the dimerization interface at least a pair of hydrophobic in

109 The unique solution dimerization interface at low ionic strength was mapped

110 ond, hitherto unidentified, helix-turn-helix dimerization interface at the C-terminal end of the olig

111 molecular-dynamics simulations, we propose a dimerization interface between alpha-helices 4 and 5 and

112 aper in this issue of Proceedings, reveals a dimerization interface between catalytic domains.

113 suggesting differences in the intermolecular dimerization interface between curved and planar CA latt

114 to and is predicted to disrupt the proposed dimerization interface between FLT3L monomers exhibits a

115 These data demonstrate that the dimerization interface between TAP1 and TAP2 and the tap

116 ystem for further structural analysis of the dimerization interface between the RAR and RXR ligand bi

117 odurans phytochrome, we demonstrate that two dimerization interfaces between sister GAF and HK domain

118 Mutations at the predicted dimerization interface block dimerization and reduce the

119 merization; and (6) F1443 is involved in the dimerization interface but is exposed to the solvent.

120 n to the output module likely depends on the dimerization interface but its architecture and response

121 s variants is not a result of defects in the dimerization interface but rather disparate global prope

122 g domains are covalently linked across their dimerization interface by a disulfide bond formed by a h

123 f the model, disruption of the known PhoB(N) dimerization interface by mutation led to markedly slowe

124 al capsid CTD but uses an entirely different dimerization interface caused by swapping the MHR-like e

125 Here, we reveal that two separate dimerization interfaces, combined with the cAMP-induced

126 ing motifs in the active site and a distinct dimerization interface compared with other ATP sulfuryla

127 ace that does not directly contribute to the dimerization interface completely abolishes this couplin

128 within a highly symmetrical region at the IN dimerization interface, composed of a four-tiered aromat

129 ion decreased upon adding EGF fall along the dimerization interface, consistent with models derived f

130 coexpressed support the idea that the CA-CTD dimerization interface consists of two reciprocal intera

131 tions were enabled by charge reversal at the dimerization interface, defining the basis of lipid IV(A

132 n site determinants (Ser74 and Phe76) in the dimerization interface destabilized the dimer in solutio

133 rast to the localized folding induced in the dimerization interface, DNA binding leads to unfolding o

134 binds an ephrin ligand through an expansive dimerization interface dominated by the insertion of an

135 Mutations in the Nef dimerization interface dramatically reduced both Nef-ind

136 boring residues have evolved to engineer its dimerization interface, enabling it to subserve specific

137 Existing structural data suggest that two dimerization interfaces exist between the GAF and HK dom

138 argest RR subfamily, which share a conserved dimerization interface for phosphorylation-mediated tran

139 lice site of TyrRSDeltaE2-3 prevented either dimerization interface from forming, and yielded a predo

140 precise nature of the functional form of CTD dimerization interface has been a subject of considerabl

141 omain (residues 1-105), lacking a C-terminal dimerization interface, has been constructed and the NMR

142 hile many of the binding interactions at the dimerization interface have been extensively studied, th

143 al high-resolution structures of the CTD-CTD dimerization interface have been reported, based on X-ra

144 ance and structural requirements to form the dimerization interface have yet to be elucidated.

145 on the heme-proximal side (helix H5), at the dimerization interface (helices H6 and H7 and loop L7) o

146 S1, S2), as well as residues located at the dimerization interface (helices H9 and H10).

147 ed the solvent exposure of the globin domain-dimerization interface (helix H6) as well as the flexibi

148 ulation of residues involved in the receptor dimerization interface identified one residue (position

149 0 proteins, and we have defined an extensive dimerization interface in A20.

150 h protein is preserved via the kinase domain dimerization interface in all variants, full-length AfGc

151 Disruption of the dimerization interface in cells causes transcription def

152 ed MHR residues and other amino acids at the dimerization interface in CTD folding, stability, and di

153 Our crystal structure also reveals a dimerization interface in GATA that has previously been

154 This sequence was originally found at the dimerization interface in glycophorin A, and it promotes

155 This energetic dissection of the dimerization interface in MHR-swapped CTD may also facil

156 investigated the role of the globin domain's dimerization interface in signal transduction in AfGcHK.

157 Here we show that a novel dimerization interface in the E2 transcription activatio

158 One element corresponds to a dimerization interface in the ETS domain and the second

159 ns exist between lipid IV(A) and TLR4 at the dimerization interface in the mouse complex only.

160 o a unique high-resolution structure for the dimerization interface in the noncrystalline lattice of

161 The importance of the dimerization interface in the signaling potential of wil

162 therapeutic that stabilizes an ATP-dependent dimerization interface in topo II to block enzyme activi

163 describe solid state NMR measurements on the dimerization interface in tubular CA assemblies, which c

164 CAM-1 IgSF domains (D) 3-5 revealed a unique dimerization interface in which D4s of two protomers fus

165 results suggest functional importance of the dimerization interfaces in bacteriophytochromes.

166 a sequence analysis tool to predict possible dimerization interfaces in GPCRs.

167 HIV-1 thus may leverage the dimerization interfaces in Pol to regulate assembly and

168 roves our understanding of the role of these dimerization interfaces in the mechanism of action not o

169 bation of the substrate binding site and the dimerization interface, indicating that this small molec

170 We also show that mutation in the dimerization interface inhibits editing in an RNA substr

171 Contrary to previous predictions, the dimerization interface involves the carboxyl terminus of

172 The structure shows a unique dimerization interface involving the DD-loop and EE-loop

173 oss-subunit" arrangement containing multiple dimerization interfaces involving both domains of each s

174 A key feature of the PKR dimerization interface is a salt bridge interaction betw

175 We further demonstrate that this unique dimerization interface is crucial for their biological a

176 or a structure-guided approach targeting the dimerization interface is described through the design a

177 rbB3 extracellular domain (ECD) in which the dimerization interface is exposed.

178 tor chaperones dimerize, the location of the dimerization interface is in dispute.

179 The structure reveals a dimer, in which the dimerization interface is mediated by the cleavage domai

180 Therefore, identification of the TLR4-TIR dimerization interface is one key to the rational design

181 cryogenic electron microscopy (cryoEM), the dimerization interface is substantially disordered.

182 This dimerization interface is validated by peptide mapping t

183 The existence of both dimerization interfaces is critical for thermal reversio

184 c interactions at both N-domain and C-domain dimerization interfaces is required to abrogate the abil

185 We find that the dimerization interface lies on a surface region remote f

186 nique heterodimerization that is mediated by dimerization interfaces located in their DNA-binding dom

187 mutations associated with one such potential dimerization interface markedly perturb SP2D oligomeriza

188 ly more favorable target sites away from the dimerization interface may also lead to subunit dissocia

189 resence of a preferential 2-fold symmetrical dimerization interface mediated by transmembrane helix 1

190 This C-terminal dimerization interface might be important for the assemb

191 Rather, mutating the dimerization interface mitigates DNA-induced changes in

192 imerization was probed further by generating dimerization interface mutants (N381A and R385A) of V. c

193 ation, we used confocal imaging to show that dimerization interface mutants of M fail to assemble int

194 Dimerization interface mutations destabilize the M dimer

195 ause MD-2 residues 122 and 125 reside at the dimerization interface near the pocket entrance, surface

196 The DNA-binding domain dimerization interface observed in our structures is ess

197 The dimerization interface observed in the X-ray structure w

198 The GxxxG motif is frequently found at the dimerization interface of a transmembrane structural mot

199 otypes altered residues located close to the dimerization interface of BirA.

200 elix transition that extends the coiled-coil dimerization interface of CAP by 3 turns of helix and co

201 ibitors that function through binding to the dimerization interface of caspases.

202 motifs including a domain homologous to the dimerization interface of cyclic adenosine monophosphate

203 the role of hydrophobic interactions in the dimerization interface of Gcn2p.

204 se that the new anion binding site along the dimerization interface of HICA is an "escort" site that

205 The focus of our studies is to target the dimerization interface of HIV-1 protease because disrupt

206 biomedically significant PPIs, including the dimerization interface of HIV-1 protease.

207 sulfated N terminus of CCR2 destabilizes the dimerization interface of inactive dimeric MCP-1, thus i

208 gly similar to that of Mad2 and binds at the dimerization interface of Mad2.

209 inding site partially overlaps with the homo-dimerization interface of Nup145C, suggesting competing

210 ing A'alpha-helix that comprises part of the dimerization interface of PAS1 prevent transmission of t

211 tal structure also reveals a protein-protein dimerization interface of PCBP2 KH1 located on the oppos

212 e location of the mutation suggests that the dimerization interface of PcrH mirrors that of the Yersi

213 The dimerization interface of PfAOP is representative of an

214 apeptide sequence (TSFTYTS) adapted from the dimerization interface of protein NuG2 [PDB ID: 1mio].

215 The dimerization interface of rA3G-CD1 is important for olig

216 Here we report how five changes in the dimerization interface of RctB affect the protein.

217 on domain and the previously identified main dimerization interface of RXR act autonomously to affect

218 with caspase-7 reveals that it binds to the dimerization interface of the caspase, another common st

219 , nucleolytic center formed at an N-terminal dimerization interface of the cleavage core.

220 e mixed by modifying two salt bridges at the dimerization interface of the Deinococcus radiodurans ph

221 electrostatic interactions found within the dimerization interface of the Nef X-ray crystal structur

222 H hydrolase activity and is localized to the dimerization interface of the protein, suggesting a rela

223 A single point mutation in the dimerization interface of the ULD not only abrogated dim

224 ynamics simulations, we find that the N lobe dimerization interface of the wild-type EGFR kinase doma

225 ormation, mutations were introduced into the dimerization interface of v-Rel to generate v-Rel mutant

226 15 modifications occur at catalytic sites or dimerization interfaces of enzymes.

227 ked to cellular transformation and implicate dimerization interfaces of oncogenes as potential drug t

228 gamma signaling, potentially by disrupting a dimerization interface on JH2.

229 f IAPP by controlling access to the putative dimerization interface on the hydrophobic face of the am

230 is currently available, the location of the dimerization interface on the protein structure is not k

231 The dimerization interfaces on PKR and GCN2 were localized t

232 Interaction with RXR occurs via two dimerization interfaces, one in the DNA-binding domain a

233 n at, or immediately adjacent to, either the dimerization interface or the hormone-binding site.

234 t some cancer-linked mutations distal to the dimerization interface, particularly the widespread L834

235 vealed that FX interacts with hBD6 along the dimerization interface, primarily contacting the alpha-h

236 ral observations, mutations that disrupt the dimerization interface produced IRE1alpha molecules that

237 Our model describes E1-E2 ectodomain dimerization interfaces, provides a structural explanati

238 containing segment forms a major part of the dimerization interface, providing a structural mechanism

239 ding of DNA facilitates opening of an enzyme dimerization interface, providing visual evidence for a

240 ls an autoinhibited configuration, where the dimerization interface recently identified in activated

241 e-chains corresponding to the matching HIV-1 dimerization interface regions were prepared; all four i

242 es of CRT oligomers, we identify an N-domain dimerization interface relevant to both WT CRT and CRTDe

243 large part of helix H10, a component of the dimerization interface, remained undetectable even after

244 Mutations in the nuclear export sequence or dimerization interface render cells temperature sensitiv

245 mask the substrate-binding site, but not the dimerization interface, rendering reduced zinc-free Hsp3

246 xpressing Nef variants with mutations in the dimerization interface replicated poorly and were signif

247 tumor derived p53 mutations reveals that the dimerization interface represents a third hot spot for m

248 At the dimerization interface, residues located at the carboxy

249 dditional 103 residues N-terminal to the Pbx dimerization interface restored heterodimerization with

250 and ninth-heptad mutants via a heterologous dimerization interface restores both corepressor interac

251 Site-directed mutations in its putative dimerization interface result in a dimerization-deficien

252 ions of CXCR4 residues located at a putative dimerization interface result in monomerization of the r

253 earing of contacts within the CENP-A:CENP-A' dimerization interface results in a weaker four helix bu

254 The dimerization interface revealed here was unanticipated a

255 main (MET567), which is assembled around the dimerization interface seen in the crystal structure of

256 n in the amino domain, particularly at their dimerization interface segments.

257 In addition to the coiled coil dimerization interface (Sir4CC interface), a crystallogr

258 Structural analysis identified an extensive dimerization interface stabilized by hydrogen bonds and

259 The dimerization interface structure in noncrystalline CA as

260 and binds in an elongated cleft spanning the dimerization interface such that the HIP and CoA moietie

261 The structural mapping of the dimerization interface suggests that Tyr10, His13, Phe30

262 s in the carbohydrate recognition domain and dimerization interface that are involved in immune funct

263 erved residues on the surface and within the dimerization interface that are required for the Rock-Sh

264 Although this helix in ERK2 forms a dimerization interface that becomes protected from HX up

265 This C-terminal domain is also a novel dimerization interface that functions independently of t

266 hat of the Yersinia homolog SycD and not the dimerization interface that had previously been reported

267 talytic triad residues and reveal an altered dimerization interface that is not conserved in the amid

268 y structure elements and in the "lasso/post" dimerization interface that may be functionally importan

269 action surface of RasGRP1 is hidden within a dimerization interface that may be stabilized by the C-t

270 minal to this inhibitory helix exposed a Pbx dimerization interface that orchestrated cooperative DNA

271 Here we study the roles of two dimerization interfaces, the so-called strand-swap and X

272 in some cases, TLR1, at the vicinity of the dimerization interface; the cationic headgroups form mul

273 es of MS-DesK, triggering a switching of the dimerization interface to allow the formation of a serin

274 steric network linking a cryptic site at the dimerization interface to enzyme function.

275 elease of the regulatory region from the NBD dimerization interface to promote dimerization and there

276 e involving helix-12 which forms part of the dimerization interface used to bind transcriptional coac

277 cognition helix (Lys(179), Met(186)) and the dimerization interface (Val(197), Leu(201)) that are imp

278 Further, we found that an intact GR dimerization interface was a prerequisite for the suppre

279 In contrast, only one dimerization interface was found for a fusion-inactive p

280 Through deletion analysis, the dimerization interface was mapped to the DNA-binding dom

281 Furthermore, a HINa dimerization interface was observed in structures of p20

282 erent cargo rely on different regions of the dimerization interface, we generate RcdA variants that a

283 orm inter-molecular salt bridges in the CtBP dimerization interface were swapped.

284 he second zinc binding domain that forms the dimerization interface when RXR binds as a dimer to a di

285 region has an autoinhibitory function and a dimerization interface, which appears to mediate positiv

286 341, and Glu-348, buried within the interior dimerization interface, which complement with three Nuf2

287 nt mutation located in the C-lobe asymmetric dimerization interface, which shows enhanced phosphoryla

288 ution, and the crystal structure reveals the dimerization interface, which we validate by mutagenesis

289 ers bind DNA sequentially and assemble their dimerization interface while bound to DNA.

290 ers bind DNA sequentially and assemble their dimerization interface while bound to DNA.

291 onomers bind DNA sequentially and form their dimerization interface while bound to DNA.

292 unit bind bicarbonate ion exclusively at the dimerization interface, while the remaining 10 chains bi

293 tion in vitro by targeting the alpha4-alpha5 dimerization interface with a novel RAS-specific monobod

294 rs rotate relative to each other, yielding a dimerization interface with more inter-subunit interacti

295 bilin-binding region of BphP also provides a dimerization interface with the C-terminal kinase domain

296 e copper (Cu(2+)) binding site at the H3-H3' dimerization interface with unknown function.

297 HP1a and HP1b differ in the dimerization interface, with HP1a having an Arg at posit

298 make a contact that likely represents the DH dimerization interface within an intact PKS.

299 structural family of hits bind at the LC-LC dimerization interface within full-length LCs, utilizing

300 Our results reveal a large dimerization interface within the membrane environment,