ライフサイエンスコーパス: dimethylglycine

1 t induces transcription in response to GB or dimethylglycine.

2 nors such as serine, glycine, sarcosine, and dimethylglycine.

3 4%, P = 0.000), and plasma concentrations of dimethylglycine (1.25 vs. 1.65 ug/mL, P = 0.021).

4 elated with clinical stage of HCC, were NAA, dimethylglycine, 1-methylnicotinamide, methionine, acety

5 ine, N-ethylglycine, and L-proline), but N,N-dimethylglycine, a tertiary amine, is not a substrate.

6 erase activity of BHMT-2 is not inhibited by dimethylglycine and betaine, whereas the former is a pot

7 levated sarcosine but further methylation to dimethylglycine and choline was decreased.

8 ptors such as nitrate or fumarate, producing dimethylglycine and CO2 as products.

9 edicted to convert GBT and homocysteine into dimethylglycine and methionine, a compound SAR11 cannot

10 roup from betaine to homocysteine to produce dimethylglycine and methionine, respectively.

11 converts glycine betaine and cob(I)alamin to dimethylglycine and methylcobalamin.

12 aecum associated with brain function such as dimethylglycine and N-acetyl-L-tyrosine profiles as comp

13 reductive and oxidative half-reactions using dimethylglycine and O2 as substrates.

14 d higher concentrations of choline, betaine, dimethylglycine, and sarcosine (12-46%; P </= 0.08) in b

15 gues were prepared from pentaerythritol, N,N-dimethylglycine, and their corresponding fatty acyl grou

16 ma folate, cobalamin, free choline, betaine, dimethylglycine, and total homocysteine (tHcy) were meas

17 ers of choline metabolism [choline, betaine, dimethylglycine, and trimethylamine N-oxide (TMAO)] and

18 es after facile one-step derivatization with dimethylglycine based on the principles of multidimensio

19 nium, N,N-dimethylaminoethanol, choline, N,N-dimethylglycine, betaine, acetylcholine, (3-carboxypropy

20 tus, low status was associated with a higher dimethylglycine/betaine ratio from 15 GW and with lower

21 though formate production from sarcosine and dimethylglycine (choline metabolites) was significantly

22 2, characterized by higher concentrations of dimethylglycine, choline, methionine, and betaine; and P

23 Betaine and dimethylglycine concentrations were also significantly h

24 Dimethylglycine dehydrogenase (DMGDH) (E.C. number 1.5.9

25 n acyl-CoA dehydrogenase, was incubated with dimethylglycine dehydrogenase and electron transferring

26 thylation reactions conducted by the enzymes dimethylglycine dehydrogenase and sarcosine dehydrogenas

27 formaldehyde by sarcosine dehydrogenase and dimethylglycine dehydrogenase from their respective subs

28 ectron transferring flavoprotein and porcine dimethylglycine dehydrogenase or sarcosine dehydrogenase

29 ( approximately 35% identity) with rat liver dimethylglycine dehydrogenase, a sarcosine dehydrogenase

30 ly related to the mitochondrial flavoprotein dimethylglycine dehydrogenase, which functions in cholin

31 nity constants of 2.0 and 5.0 microm for the dimethylglycine dehydrogenase-electron transferring flav

32 ionization-mass spectrometry signal for the dimethylglycine dehydrogenase.electron transferring flav

33 genases have the ability to compete with the dimethylglycine dehydrogenase/sarcosine dehydrogenase fa

34 betaine (Bet) to homocysteine (Hcy) to form dimethylglycine (DMG) and methionine (Met).

35 Plasma dimethylglycine (DMG) and methionine were higher as with

36 ave suggested possible protective effects of dimethylglycine (DMG) on glucose metabolism.

37 and gbcB (PA5411), were capable of growth on dimethylglycine (DMG), a catabolic product of GB, but no

38 the reduction in betaine and the increase in dimethylglycine during pregnancy and strengthens the ass

39 folate status affects choline, betaine, and dimethylglycine during pregnancy.

40 solubility and oral bioavailability, the N,N-dimethylglycine ester 40 was prepared.

41 e I clinical trials as the water-soluble N,N-dimethylglycine ester prodrug 40 (CEP-7055).

42 e analyzed for plasma free choline, betaine, dimethylglycine, folate, vitamin B-12, total homocystein

43 GW and with lower plasma betaine and higher dimethylglycine from 24 to 27 GW, for the rest of pregna

44 nal choline intake also led to a doubling of dimethylglycine in cord plasma (P = 0.002).

45 ed by 34.8% (1.0%) throughout pregnancy, and dimethylglycine increased by 39.7% (2.7%) between 24-27

46 hioacetate [(CH(3))(2)S(+)CH(2)CO(2)(-)] and dimethylglycine (K(d) = 20.5 and 17.4 mM, respectively)

47 igher levels of trimethylamine-N-oxide, N,N'-dimethylglycine, m-hydroxyphenylpropionic acid, N-acetyl

48 ration of fluorinated phenyl and alpha,alpha-dimethylglycine moieties contributed to improved BBB per

49 ine N-methyltransferase (GSMT) and sarcosine dimethylglycine N-methyltransferase.

50 hose observed with sarcosine analogues (N,N'-dimethylglycine, N-benzylglycine).

51 Here we report crystal structures of dimethylglycine oxidase (DMGO) from the bacterium Arthro

52 Dimethylglycine oxidase (DMGO) is a covalent flavoenzyme

53 ehydrogenase active site of the bifunctional dimethylglycine oxidase (DMGO) of Arthrobacter globiform

54 However, in contrast to dimethylglycine oxidase and T-protein, the YgfZ family l

55 alphaB) is similar to the C-terminal half of dimethylglycine oxidase and the T-protein of the glycine

56 The covalent flavin in dimethylglycine oxidase is identified as an alphaN1-hist

57 ructure is very similar to that of bacterial dimethylglycine oxidase, an enzyme of the glycine betain

58 sma concentrations of free choline, betaine, dimethylglycine, phosphatidylcholine (PC), and sphingomy

59 f a proton from the substrate amine group of dimethylglycine prior to C-H bond breakage and FAD reduc

60 0.0001), betaine (r = 0.58, P < 0.0001), and dimethylglycine (r = 0.30, P < 0.0001) in maternal blood

61 Flavin oxidation of dithionite- and dimethylglycine-reduced enzyme by O2 occurs in a single

62 d plasma concentrations of choline, betaine, dimethylglycine, retinol, essential fatty acids, methion

63 0.001) but lower concentrations of betaine, dimethylglycine, sarcosine, and methionine (13-55%; P <

64 GbdR regulon includes the genes encoding GB, dimethylglycine, sarcosine, glycine, and serine cataboli

65 nal region binds FAD covalently and oxidizes dimethylglycine to a labile iminium intermediate.

66 ved in the metabolism of choline, converting dimethylglycine to sarcosine.

67 e, folinic acid, methyl-B(12), thymidine, or dimethylglycine to the cultured trisomy 21 lymphoblastoi

68 hat catalyzes the oxidative demethylation of dimethylglycine to yield sarcosine, formaldehyde, and hy

69 ethionine (SAM), homocysteine, cysteine, and dimethylglycine were also assessed monthly.

70 omocysteine, cysteine, choline, betaine, and dimethylglycine were associated with increased As methyl

71 Plasma free choline, betaine, and dimethylglycine were lower in women at 36 wk of gestatio

72 MR spectroscopy, revealed that his levels of dimethylglycine were much higher than control values.

73 se comparisons include increased citrate and dimethylglycine with a decrease of creatinine and methio