ライフサイエンスコーパス: diminution

1 of the UCS alone were included to assess UCR diminution.

2 its a large (>10,000-fold) specific activity diminution.

3 ly 1.0 mA resulted in sustained excitability diminution.

4 ucleation resulting in actin filament length diminution.

5 y of DNA cleavage, albeit without a dramatic diminution.

6 ent processes that drive synaptic growth and diminution.

7 EFV was limited (-27+/-11%) compared to VAF diminution (-40+/-19%).

8 double stem-loop insertions as well as loop diminutions affecting RNA structural elements that are o

9 ng in the hematopoietic system that include: diminution and decreased competence of the adaptive immu

10 s in diverse species, but the function(s) of diminution and the specificity of sequence loss remain l

11 R4 and MR-2 does not result in PML-RARalpha diminution and the tested gene expressions.

12 I at HS2 and within cHS4, accompanied by its diminution at the gene promoter.

13 found to play an integral role in either the diminution (compressibility) or retention (incompressibi

14 Here, we report that this diminution correlates with alterations in the gut microb

15 patocytes, and the effects persisted without diminution for 10 days.

16 d against other antigens; the basis for this diminution has not been elucidated fully.

17 y size in bonobos for the purposes of signal diminution (i.e., reducing the impression of body size t

18 Appearance of ectropion uveae showed diminution in 15 tumors (43%); newly present corectopia

19 marrow-derived macrophages revealed a marked diminution in a proinflammatory M1 phenotype due to decr

20 active site glutamate, E241Q, showed a large diminution in activity with ametryn, no detectable activ

21 ionyl specificity as predicted and displayed diminution in activity, but the decreases in activity we

22 , no quantitative examination of microtubule diminution in AD and its relationship with PHFs has been

23 Diminution in allantoic cell number and proliferation wa

24 3.8%, which correlated with a corresponding diminution in apical GLUT2 levels: the SGLT1 component a

25 Thus the decades-long, controlled diminution in athletic performance, should not be seen a

26 ividuals during the breeding season, and any diminution in attractiveness could compromise reproducti

27 suppression of SIRT1 and AMPK, leading to a diminution in autophagic flux in glomerular podocytes an

28 ituximab therapy is associated with variable diminution in B cell numbers.

29 ction in gut bacterial load and long-lasting diminution in bacterial diversity, antibody responses we

30 f platelet activation resulted in a profound diminution in both experimental and spontaneous metastas

31 the dominant negative forms of Rab27b caused diminution in both numbers and length of dendrites of me

32 ers, neuronal cell counts, astrogliosis, and diminution in brain and serum ceramide levels in Cln3 (D

33 infers that an individual has a significant diminution in brain volume.

34 Diminution in bypass efficiencies was also observed for

35 ndritic cells (DCs), which correlates with a diminution in CD103(+) DC numbers in the lamina propria.

36 SP caused a diminution in CD4(+) T cell surface expression of the HI

37 rus subgenomic messages, whereas no dramatic diminution in cellular translation was observed.

38 plain the hydrophobic force and its reported diminution in deaerated water.

39 terial growth is controlled, and there is no diminution in either the number of IFN-gamma-producing A

40 studies revealed that there is no detectable diminution in functional opioid receptors in spinal tiss

41 A3G catalytic activity was required for the diminution in G-to-C mutagenesis.

42 methylation cycle, but we did not detect any diminution in global DNA methylation, in contrast to emb

43 No further diminution in gluconeogenic flux to G6P occurred over th

44 ated decline in drug metabolism as well as a diminution in growth hormone secretion.

45 es 36, 120, 153, and 155 are modest (<8-fold diminution in k(cat)).

46 hosphate, is characterized by a >42,000-fold diminution in k(cat), indicating the critical involvemen

47 Minimal decreases in T cells and a partial diminution in macrophages were observed.

48 to normal tissues generally reveals a strong diminution in mitochondrial content and in oxidative pho

49 In contrast to this similar diminution in mRNA, kinome analyses using a peptide arra

50 pulations could respond, indicating that the diminution in naive ABLE cell responses was not due to l

51 These events were associated with a marked diminution in nuclear factor kappaB (NF-kappaB)/DNA bind

52 old oocytes to NO resulted in a significant diminution in OMD and ZP dissolution time, whereas spont

53 Contrary to an anticipated diminution in pathology, CD14(-/-) mice exhibited more s

54 ion over extended periods and did not show a diminution in performance in any of the matrices.

55 cytic phagocyte survival (8-fold), a drastic diminution in peritoneal bacteria counts, and a 50-70% r

56 lts in a milder loss of microtubule mass and diminution in process length.

57 prevented p27 stabilization and blocked the diminution in proliferative potential that normally acco

58 tive increase in thromboxane, coupled with a diminution in prostacyclin in infarcted heart muscle, ca

59 hypotheses are advanced to explain both the diminution in rates with increased surface coverage and

60 time reduction then recovery suggesting that diminution in receptor proteins contributes to the phago

61 is some increase in gynecologic symptoms and diminution in sexual pleasure, survivors tended to have

62 In scanning electron microscope analysis, diminution in silicone was observed.

63 ot doubling in size at 1 month, at least 50% diminution in size at 3 months, and complete reepithelia

64 for ASO, delay of repair is associated with diminution in size of PV, which may subsequently reduce

65 se processes for stem cells can be profound: diminution in stem cell pools, or, because of altered ge

66 ary-adrenocortical (HPA) axis is marked by a diminution in stress responsiveness early in the postnat

67 rization of mammalian BiP and a coincidental diminution in substrate binding, pointing to the relativ

68 ar copper concentration resulted in a marked diminution in the abundance of this protein.

69 the activity of the p38 stress kinase and a diminution in the activity of the antiapoptotic Akt/PKB

70 der these conditions, there is a progressive diminution in the capacity to produce IL-2, TNF-alpha, a

71 cuity and RNFL thickness also showed greater diminution in the contralateral eye (P = .040 and P = .0

72 evels of Bcl-2, Bcl-x(L), and survivin and a diminution in the degree to which these anti-apoptotic p

73 R deposition may be the direct result of the diminution in the distant chaperoning capacity of the li

74 audate putamen was decreased, representing a diminution in the dopamine storage pool.

75 antibacterial activity of the AgNPs through diminution in the extent of nanoparticle aggregation.

76 and stenting has been achieved with a marked diminution in the incidence of restenosis.

77 dThd as substrate, apart from Y21E (350-fold diminution in the k(cat)/K(m)).

78 he prostate is associated with a significant diminution in the level of a key regulator of prostate c

79 m survival of the CD4-deficient group and no diminution in the level of persistent virus shedding and

80 Diminution in the nematode Ascaris suum occurs during ea

81 Fibrinogen deficiency resulted in a dramatic diminution in the number of colonic adenomas formed foll

82 tion of SPG11-NPCs resulted in a significant diminution in the number of neural cells.

83 nd spermatids of the null mice showed marked diminution in the size of chromatoid bodies.

84 receptor interaction conferred a concomitant diminution in their abilities to promote membrane fusion

85 n substantial loss of microtubule mass and a diminution in total process length.

86 These results demonstrate that the diminution in TUNEL staining by alpha-MSH is through alp

87 This marked diminution in VlsE lower forms paralleled the clearance

88 We propose that diminution is a mechanism of germline gene regulation th

89 This diminution is not a sampling artifact.

90 Chromatin diminution is the programmed elimination of specific DNA

91 onse to M. tuberculosis infection, and their diminution may promote the intracellular survival of M.

92 This diminution might have occurred decades ago, but could be

93 Oxytocin microinjection produces a diminution of (1) flinches induced by formalin and (2) s

94 m iodide as a source of free iodide led to a diminution of (99m)Tc-pertechnetate uptake in both mouse

95 Recent reports have shown a marked diminution of 15-PGDH expression in colorectal carcinoma

96 ed on both a non-significant enhancement and diminution of 2-back and 0-back performance, respectivel

97 CS relative to sham stimulation, with a mean diminution of 31% (SD=14; d=1.58, 95% CI=0.76-2.40).

98 of 4.1R in mouse red cells leads to a large diminution of actin accompanied by extensive loss of cyt

99 low 30 amino acids resulted in a significant diminution of activity.

100 psychological growth over time had a greater diminution of ADHD severity and impairment.

101 resent self-assembly processes guided by the diminution of adhesive-free energy as cells tend to maxi

102 A previously undescribed diminution of afferent neuronal voltage-dependent potass

103 aired group, higher CR was associated with a diminution of age-related alterations in CSF biomarkers

104 ng, DC10s to OVA-asthmatic mice, significant diminution of airway hyperresponsiveness (AHR) was first

105 a), impeded tumorigenesis with a concomitant diminution of Akt phosphorylation.

106 o PrPSc conversion is thought to involve the diminution of alpha-helical domains accompanied by the i

107 Diminution of AMPK signaling in vivo correlates with inc

108 e of adrenal-transplanted rats, suggesting a diminution of anterograde axoplasmic transport by adrena

109 n the defensin genes expression suggesting a diminution of antibacterial functions of epithelial cell

110 at VP through elevation of ROS anabolism and diminution of antioxidant detoxification.

111 These data indicate that diminution of AP endonuclease has a significant effect o

112 To directly test whether a genetic diminution of AP endonuclease results in increased spont

113 complex I activity and increased ROS but no diminution of ATP production.

114 8) resulted in the loss of virulence and the diminution of avirulence activity of AvrPtoB(1-307), whe

115 effect of treatment indicated a progressive diminution of benefit with increasing CAC.

116 n heart failure, a condition associated with diminution of beta-adrenergic receptor (beta-AR) respons

117 xation of secondary structure, manifested as diminution of beta-sheet content in conjunction with a d

118 Drying caused a diminution of bioactive compounds and influenced color p

119 of CDPK1 is also associated with significant diminution of both rhizobial and mycorrhizal symbiotic c

120 Glu-235, His-269, or Asp-320 resulted in the diminution of catalytic activity by two to six orders of

121 was remarkably elevated in parallel with the diminution of Ccnd1 encoding the crucial cell cycle regu

122 robial sepsis following adoptive transfer or diminution of CD71(+) erythroid splenocytes under these

123 Diminution of CDC6 level in mouse zygotes by two differe

124 and complement receptors resulted in a major diminution of cell-to-cell transfer events.

125 Furthermore, overall diminution of cellular RNA synthesis is also observed in

126 he mobilization of storage compounds and the diminution of cellular stress resistance.

127 No diminution of cellular uptake is observed under metaboli

128 hancing dynamin-dependent endocytosis, (2) a diminution of channel open probability (P(o)) that occur

129 n infected macrophages resulted in a gradual diminution of chlamydial antigens, although some of thes

130 ve studies were done using mice with genetic diminution of circulating FII.

131 As, and competition experiments in which the diminution of cleavage was measured following admixture

132 e adverse effects of unchecked elongation or diminution of coding ends during V(D)J recombination, th

133 y specimens of women with striae also show a diminution of collagen.

134 titative way, and also a lower percentage of diminution of colour.

135 growth accompanied by fibrosis and eventual diminution of contractility, which results from down-reg

136 inhibition of CRP surface binding and, thus, diminution of CRP-mediated complement deposition.

137 s involving integrins, and the elevation and diminution of cytoplasmic signalling molecules.

138 yltransferase (DNMT) activity and the forced diminution of DNMT-1, DNMT-3a, and DNMT-3b by siRNA targ

139 ar factor (NF)-kappaB activity, resulting in diminution of downstream inhibitors of TNF signaling.

140 creased degeneration of outer hair cells and diminution of DPOAE amplitudes but no difference in dege

141 crease in vascular permeability accompanying diminution of dysplastic microvasculature by the antiang

142 A/CIN85 complex by Alix was reflected in its diminution of EGFR internalization.

143 s the aggregation of voids in the system and diminution of elastic properties.

144 2% yield) and shorter reaction times with no diminution of enantioselectivity (91-98% ee).

145 15 residues (IN 273) resulted in incremental diminution of enzymatic function and infectivity and tha

146 -IL5(OXA) EoE mice resulted in a significant diminution of epithelial eosinophilia in addition to bas

147 expressing either wild-type or mutant EGFR, diminution of expression of both L858R and EGFR delL747-

148 which the pathogen avoids detection through diminution of extracellular receptors and attenuation of

149 This was followed by a diminution of far-red fluorescence emission from the cor

150 evering protein cofilin, and a corresponding diminution of filamentous actin.

151 It is widely thought that diminution of first-phase insulin release is the earlies

152 g diminish with increasing pressure, and the diminution of flow at high pressure can be compensated b

153 in vitro, and one compound induced a slight diminution of food intake in a rodent model of obesity.

154 rant, prematurely terminated transcripts and diminution of full-length transcripts.

155 This model predicts that a selective loss or diminution of function of the vmPFC would result in heig

156 These effects lead to the diminution of GABAergic synapses and are correlated with

157 , the VNS-treated rats showed no appreciable diminution of GAD cells rostral to the contralateral epi

158 er, MyD88 deficiency resulted in spontaneous diminution of graft infiltrating effector cells, includi

159 Attenuation was not associated with any diminution of growth in serum or ability to utilize seru

160 rowth plate, may partially contribute to the diminution of growth in these animals.

161 s expected; however, these mutants showed no diminution of H2O2 excretion, suggesting that H2O2 is pr

162 d that CSC mediated dose- and time-dependent diminution of H4K16Ac and H4K20Me3, while increasing rel

163 5(+)CD4(+) T reg cells may contribute to the diminution of HIV-specific T cell immune responses in vi

164 hese results demonstrate that the absence or diminution of humoral immune responses by itself is insu

165 reversal produced by transient ASO-mediated diminution of huntingtin synthesis.

166 These changes combine to result in a diminution of immune responsiveness in the elderly.

167 ing this enzyme led to tightly corresponding diminution of in vivo tyrosine hydroxylase activity that

168 y in interleukin (IL)-12p40 lead to a marked diminution of inflammation in both the colon and the liv

169 Diminution of inflammatory Th1 and Th17 associated cytok

170 In control studies, no diminution of insulin signaling to the mitogen-activated

171 hey can be viewed as being reflective of the diminution of integrative physiological prowess that occ

172 ependent regression of MRTs with correlative diminution of intratumoral trimethylation levels of lysi

173 on in primary macrophages also resulted in a diminution of invasive capacity.

174 on in IR-induced G2/M arrest and concomitant diminution of IR-induced activation of ataxia telangiect

175 ting this charge to other sites results in a diminution of its effectiveness that appears to depend o

176 ylalanine or alanine results in a 10(3)-fold diminution of k(cat) and suppression of the overall kine

177 as reduced by KAI1/CD82, consistent with the diminution of lamellipodia and actin cortical network; w

178 Contrary to the diminution of LC migration in PAF receptor-deficient mic

179 ired interactions with neurons, coupled with diminution of learning and memory behaviors.

180 ne whether pain resolution is accompanied by diminution of lesions in patients with knee OA.

181 nical benefits were associated with a marked diminution of levels of circulating inflammatory cytokin

182 evidenced by a greater survival index and a diminution of liver enzymes (ALT and AST).

183 can significantly increase lifespan, without diminution of locomotor vigor, resistance to stress, or

184 ugh augmentation of type I IFN signaling and diminution of lung immunopathology.

185 Diminution of lymphoid tissue reversed pulmonary hyperte

186 pancreatic carcinogenesis and a significant diminution of MDSCs compared with KC mice at comparable

187 aB to activate a target promoter, as well as diminution of MHC-I transcription and cell surface expre

188 Diminution of MICU1 or MCU reduced mitochondrial Ca(2+)

189 n increase in granulocytic progenitors and a diminution of monocytic progenitors.

190 of glutamate to cultures results in a rapid diminution of movement and also an alteration from elong

191 In addition to a significant diminution of naive T-cell numbers, we found impaired de

192 They measure a similar diminution of nasal epithelial Ca(2+)-activated Cl(-) se

193 They measure a similar diminution of nasal epithelial Ca2+-activated Cl- secret

194 xylate C6 13C peak moves upfield, indicating diminution of negative charge, and broadens, indicating

195 the presence of FtsY, YlxM caused an overall diminution of net GTPase activity.

196 administration of calcineurin inhibitors and diminution of NETs production.

197 h of their neuronal progeny accounts for the diminution of neurons in older mutant embryos.

198 Diminution of NTAL expression by silencing RNA oligonucl

199 Withdrawal of signal leads to diminution of nuclear TFII-I, suggesting that the signal

200 The diminution of O-GlcNAc levels occurred synchronously wit

201 ks on their spectratypes, suggesting loss or diminution of overrepresented clonal T-cell populations.

202 revealed that AA produces an ilPFC-mediated diminution of pavlovian reactions that extends beyond th

203 20; and a cdh1-null mutant, we show that the diminution of Pds1p and Clb2p brought on by Tax is media

204 Such diminution of phagocytosis was examined to be associated

205 Exposure to SEMA3F-conditioned medium led to diminution of phospho-ERK1/2 in four of eight lung cance

206 gregation of C60 in water and the consequent diminution of photoactivity present a significant challe

207 ugmented the inspiratory drive potential and diminution of PIP(2) reduced it; sensitivity to flufenam

208 The progressive diminution of plasticity with age is linked to the emerg

209 We have investigated whether this diminution of polarity results in an epithelial-to-mesen

210 ng decline in synaptic vesicle numbers and a diminution of presynaptic density size.

211 There was a significant diminution of probe activation following pretreatment wi

212 -deficient Schwann cells display a transient diminution of proliferative capacity.

213 Adaptation, defined as the diminution of receptor signaling in the presence of cont

214 cline in thymic activity in RA may lead to a diminution of regulatory T cells and loss of their negat

215 longed elevation of intracellular Ca(2+) and diminution of releasable synaptic vesicles.

216 (butylene adipate) (PBA) indicated that some diminution of response occurred during the analysis of t

217 o had undergone SLT 360 degrees (SLT 1) with diminution of response over time followed by repeat SLT

218 electronically excited DA manifests a 3-fold diminution of S(1)-->S(0) oscillator strength on a 2-20

219 We found that diminution of SERCA2 function by pharmacological inhibit

220 r cluster assembly leads to a Dun1-dependent diminution of Sml1 protein levels.

221 Diminution of sodium currents, largely NaV1.7, was recap

222 Selective diminution of SRP subunits by RNA interference resulted

223 We found a striking diminution of STAT6 phosphorylation in differentiated WT

224 natural products correlates with substantial diminution of sterol synthesis, identifying HMG-CoA synt

225 Immunodomination, or diminution of subdominant epitope-specific responses by

226 ls induced by changes in reward; the loss or diminution of such teaching signals would result in slow

227 We also show that diminution of sumoylation does not affect Yku70 protein

228 kine release and receptor expression, and by diminution of T cell activation, proliferation and apopt

229 t high viral loads result in the progressive diminution of T cell effector functions and subsequent p

230 We conclude that in the absence or gross diminution of TBs, mean PNJ gap width increases signific

231 particular, age-associated telomere damage, diminution of telomere 'capping' function and associated

232 in tissue volume that was associated with a diminution of tensile integrity.

233 duals than in middle age individuals, with a diminution of that effect in suicide completers, who pre

234 for the third patient, indicate progressive diminution of the areas of improved vision.

235 rebral angiogenesis, resulting in a profound diminution of the brain microvasculature without comprom

236 TSP-1 has shown elongation of the stalk and diminution of the C-terminal globule.

237 le via maintenance of the lipogenic pool but diminution of the carnitine palmitoyltransferase 1 inhib

238 A significant diminution of the coupled activities was also observed w

239 vacuum over a ca. 5 A band with progressive diminution of the density and hydrogen bonding.

240 ree patients underwent systemic therapy with diminution of the deposits and improvement in vision in

241 owing infection indicates also that temporal diminution of the dominant antigen OspC is impaired in l

242 rimethoprim mediated concentration-dependent diminution of the emission observed at 450 nm for DHFR I

243 een a role for the proteasome and a possible diminution of the free ubiquitin pool, we expressed a ch

244 Finally, we have shown that diminution of the glycosyltransferase activity of I-bran

245 e rats, there is a loss of GnRH pulses and a diminution of the GnRH surge.

246 HOM setup, offering some explanation for the diminution of the HOM visibility observed in many experi

247 are repeatedly injected in the skin, with a diminution of the inflammatory response occurring after

248 wever, we show that there is no quantitative diminution of the initial phase of antitumor activity in

249 responses are associated with a facilitated diminution of the leukemogenic PML-RARalpha protein and

250 fferentiate in culture, resulting in a rapid diminution of the multipotent cell population and their

251 ginates from both reduction of cell size and diminution of the number of cells and correlates with im

252 onal antibody provided further evidence that diminution of the Oag content occurred in situ during le

253 inotropic infusion resulted in a significant diminution of the peripheral eosinophilia and the EM bef

254 troducing positive feedback loops results in diminution of the probability distribution complexity.

255 eria causing plant diseases that result in a diminution of the quantity and quality of food produced

256 of the mPOA may be attributable in part to a diminution of the reinforcing effects of vaginocervical

257 erozoic-Cambrian boundary, signals the final diminution of the reservoir, a process that was likely i

258 Diminution of the Th1 response in infected WSX-1(-/-) mi

259 nscious expectations of the UCS, conditioned diminution of the UCR can be expressed independent of le

260 Greater diminution of the UCR was observed to the UCS when it fo

261 Our findings demonstrate conditioned diminution of the unconditioned SCR.

262 ctron microscopy and was demonstrated by the diminution of the voltammetric signals for 5-HIAA as wel

263 led to dramatic changes in vascular tone and diminution of the VSMC layer with attenuated contractili

264 thioredoxin reductase (TR), concomitant with diminution of their cellular contents.

265 Nevertheless, there was a progressive diminution of their effector activities as their capacit

266 Diminution of these Abeta1-42 effects in primary culture

267 hment of the aquifer, leading to substantial diminution of this resource and rapid subsidence of the

268 e mechanisms initiated by early cessation or diminution of thymic output.

269 le in 3- to 4-week-old mice, but a threefold diminution of thymic T cells became evident by 6 to 8 we

270 eability and memory loss are associated with diminution of tight junctions (TJ) in brain endothelium

271 derived human DCs (mhDCs) demonstrate marked diminution of TLR3 and TLR4 mRNA expression compared wit

272 ate increased with time, whereas there was a diminution of total glutathione during this period.

273 e potential for preservation of activity and diminution of toxicity with alternative sequences and sc

274 Knockout (KO) of vimentin in MEFs caused a diminution of traction reported by TM, as well as stiffn

275 d in the formation of the active metabolite, diminution of tumor vasculature, and hemorrhagic necrosi

276 Diminution of UbcH10 expression significantly inhibited

277 nfiltrating F4/80-positive macrophages and a diminution of vessel density, but not with obvious diffe

278 iew of a 66 year old male who presented with diminution of vision in right eye 17 days after uneventf

279 tended fixation and there is a corresponding diminution of visual sensitivity at nontarget locations.

280 geldanamycin over 24 hours, whereas partial diminution of wild-type EGFR required a minimum of 200 n

281 posure to 1 micromol/L geldanamycin, whereas diminution of wild-type EGFR was less substantial and se

282 dominant negative DMRTF mutant also causes a diminution of wing interveins, whereas overexpression of

283 lytic activity of human ANG, resulted in the diminution of xenograft tumoral growth through the inhib

284 grow under restricted water regimes without diminution of yield would minimize drought-related losse

285 nd promoter mutations lead to dysregulation (diminution) of Chga in brainstem cardiovascular control

286 analysis showed reproducible enrichment (or diminution) of particular TCR clonotypes across all chal

287 The diminution or elimination of signals due to nonphosphory

288 rn are, in some lineages, defined by extreme diminution or loss and, in others, by the incorporation

289 durably increased hemoglobin levels without diminution over 40 weeks.

290 er at 1 day post-injury, followed by gradual diminution over time.

291 we mechanistically demonstrate that miR-204 diminution promotes RUNX2 up-regulation and that sustain

292 However, diminution rather than total elimination of tipDC traffi

293 sophila cells it results in centriole length diminution that is overcome by codepletion of Klp10A to

294 Urea denaturation showed a diminution to the stability of the ALDH1 mutants.

295 However, conditioned UCR diminution was also observed independent of differential

296 nt with this prediction whole body carnitine diminution was identified as a common feature of insulin

297 However, the mechanism of MEA-mediated PTI diminution was not known.

298 evels in the remainder, suggesting that such diminutions were triggering the overall synaptic patholo

299 omerase activity, demonstrates a significant diminution with age but a marked response to injury, and

300 support the following disease sequence: ONL diminution with INL thickening; amalgamation of residual