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1 perazin-1-yl]-3-cyclohexyl-1H-pyrimidine-2,4-dione).
2 oxybenzylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione).
3 generate a 5-acetoxy-5-benzyloxazolidine-2,4-dione.
4 generation of ruthenium(0) and the requisite dione.
5 c aldehydes, aromatic amines, and butane-2,3-dione.
6 n 98.6% ee and 39% yield from cyclohexan-1,3-dione.
7 s and 3.6% overall yield from cyclohexan-1,3-dione.
8 the reaction product 1,4-androstadiene-3,17-dione.
9 -2,3- bis(methylthio)cyclohexa-2,5-diene-1,4-dione.
10 by loss of alcohol to indeno[1,2-b]pyran-4,5-diones.
11 logenation reactions of 4,4'-bipyridine-2,2'-diones.
12 nones, 3-butyne-1,2-dione, and 4-pentene-2,3-diones.
13 approach to 1,7-dioxaspiro[4.4]non-2-ene-4,6-diones.
14 g to substituted chromeno[3,4-c]chromene-6,7-diones.
15 nation generating 6,7-dihaloisoquinoline-5,8-diones.
16 n-7-ones and 2-R-anthra[2,1-b]thiophene-6,11-diones.
17 ylates versus benzazine-3-ones/benzazine-2,3-diones.
18 rrangement to furnish 1,4-benzodiazepine-2,5-diones.
19 lium bromides and prochiral cyclopentene-1,3-diones.
20 yl)benzyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione].
22 1-phenyl-3-(3,5-dimethoxyphenyl)-propane-1,3-dione (1), a molecule with two methoxy groups in one of
23 )phenyl)amino)-3-(methylthio)naphthalene-1,3-dione (1), demonstrated significantly higher potency ex
24 , 7-acetamido-2-(8'-quinolinyl)quinoline-5,8-dione (11) and 7-amino-2-(2-pyridinyl)quinoline-5,8-dion
25 hthalic peranhydride (9), and benzofuran-2,3-dione (11) and also by matrix photolysis of 9, 11, and 2
26 cogenin) and 11alpha-hydroxypregn-4-ene-3,20-dione (11alpha-hydroxyprogesterone) were used as startin
27 thalen-1-ylmethyl)-1,2,4-triazine-3,5(2H,4H)-dione 11h was found to be selective over a number of tar
30 13)C-labeled 1a to hepta-1,2,4,6-tetraen-1,7-dione (17a) by means of electrocyclic ring opening follo
31 e N-unsubstituted 1H-2,3-benzoxazine-1,4(3H)-diones (17a-e) at rates that were dependent on temperatu
32 ylmethylidene)dioxy]-19-norpreg n-4-ene-3,20-dione ((18)F-FFNP), as well the feasibility of imaging t
33 lin- 2-yl)ethyl)-4-isopropoxyisoindoline-1,3-dione ((18)F-MNI-654) and 2-(2-(3-(4-(2-fluoroethoxy)phe
34 lin-2-yl)ethy l)-4-isopropoxyisoindoline-1,3-dione ((18)F-MNI-659), with the goal of selecting the be
35 iallylated or 2,2-dipropargylated indane-1,3-diones 2 followed by stereoselective radical cyclization
37 l-1H-pyrrol-3-yl)methylene)thiazolidine-2,4- dione (2), a thiazolidine-2,4-dione, was obtained from a
39 11) and 7-amino-2-(2-pyridinyl)quinoline-5,8-dione (23), showed selective cytotoxicity toward the NQO
40 inhibitor (R)-benzopyrimido-pyrrolo-oxazine-dione-27 (BPO-27) in reducing bile acid-induced fluid an
41 is(2-aminoethylamino)anthra[2,3-b]furan-5,10-dione (2a) binds to RG4s in the KRAS transcript under lo
42 -aminoethylamino)anthra[2,3-b]thiophene-5,10-dione (2b) repress translation in a dose-dependent manne
43 ly to sulfonyl azides, 6-azidopyrimidine-2,4-diones 2o-q react with cyanothioacetamides to form N-pyr
44 ylamine (SKA-31), 6,7-dichloro-1H-indole-2,3-dione 3-oxime (NS309), and 1-ethylbenzimidazolin-2-one (
45 a)2.1 than NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime), an unselective but hitherto the most pot
46 , including xanthones, 9 H-xanthen-2,9(4a H)-diones, 3 H-spiro[benzofuran-2,1'-cyclohexa[2,5]diene]-3
47 ctyldodecyl)pyrrolo[3,4-c]pyrrole-1,4(2H,5H)-dione-3,6-diyl)-alt-(2,2';5',2'';5'',2'''-quaterthiophen
49 S309, SKS-11 (6-bromo-5-methyl-1H-indole-2,3-dione-3-oxime) and SKS-14 (7-fluoro-3-(hydroxyimino)indo
50 yl-2-bute n-1-yl)-2H-1-benzopyran-4,7(3H,8H)-dione; 3-[(2-O-beta-d-glucopyranosyl-beta-d-glucopyranos
51 midazo[1',5':1,6]pyrido[3,4-b]indole-1,3(2H)-dione (31a) emerged as a potent (IC(50) = 4.10 +/- 1.2 n
52 exahydro-2H-pyrazinopyrrolo[2,3-b]indole-1,4-dione 39, which in turn is available in enantiomerically
53 n of thioamides 3 with 3-tosyloxypentane-2,4-dione 4 led to in situ formation of 5-acetylthiazole 5 w
55 1-(4-hydroxyphenyl)-2-phenylpyrazolidine-3,5-dione (4-OH-OPB) killed both replicating and NR Mtb, inc
56 into the corresponding enantiomerically pure diones 4b, the absolute configuration of which was deter
57 lly pure N-Boc 9-azabicyclo[3.3.1]nonane-2,6-dione (4b), a potentially useful chiral building block,
58 2H-Indazol-3-yl)methylene]-1H-indene-1,3(2H)-dione 6 and (E)-2-[(2H-indazol-3-yl)methylene]-2,3-dihyd
59 pansion to quinazolino[4,5-b]quinazoline-6,8-dione 7 rather than, as previously believed, its isomer
60 ed lapacho quinones, naphtho[2,3-b]furan-4,9-dione (7), was modified in the search for novel agents a
61 ro[3H-indole-3,2'(1H)quinazoline]-2,4'(1H,3H)dione 8, which was also identified as an intermediate in
64 7-aminopyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione, a Janus-type nucleobase, has been synthesized and
66 ylcyclohexyl)methoxy]benzyl}thiazolidine-2,4-dione, a thiazolidinedione peroxisome proliferator-activ
67 5-phenylthiophene-3-yl-methylpyrimidi ne-2,4-dione (ACET), on altered behavioral phenotypes in the ge
69 ctedly, substrates such as 4-androstene-3,17-dione (ADD) and 4-BNC displayed strong substrate inhibit
70 methylene) amino)-2,3dihydrophthalazine) 1-4-dione (ADD) for direct detection of ascorbic acid (AA) v
71 reactions were investigated in azetidine-2,3-diones, affording the corresponding 3,3-disubstituted-be
72 roid (3alpha,5alpha)-3-hydroxypregnane-11,20-dione (alphaxalone) with regard to time of onset and rat
73 configured 3-arylmethylidene pyrrolidine-2,5-diones (also known as arylmethylidene succinimides) thro
74 2-hexyldodecyl)-1,3-thieno[3,4-c]pyrrole-4,6-dione-alt-5,5-(2,5-bis(3-dod ecylthiophen-2-yl)thiophene
75 ed direct conversion to the isoquinoline-5,8-dione; alternatively, N-haloimides of cyanuric acid prov
76 ropyl)-5H-indeno[1,2-c]isoquinoline-5,11-(6H)dione (AM6-36) (3) is among the few RXR ligands known.
77 ted derivatives of 5alpha/beta-pregnane-3,20-dione, among which the 5beta-H-7alpha-benzoyloxy-11alpha
78 N-aryl, and N-hetereoaryl pyridopyrazine-1,6-diones, an important class of medicinally significant la
79 nd 4-((3-phenylpropyl)amino)-isoindoline-1,3-dione analogs that selectively bind BfrB at the Bfd bind
80 as pharmacological tools, a thiazolidine-2,4-dione analogue, 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl
81 azolo[4,5-b]pyridine-7,3'-indoline]-2',5(3H)-dione analogues were synthesized and evaluated as potent
82 s region with 6-cyano-7-nitroquinoxaline-2,3-dione and (2R)-amino-5-phosphonovaleric acid greatly red
83 3 (AKR1C3) converts Delta(4)-androstene-3,17-dione and 5alpha-androstane-3,17-dione to testosterone (
85 exahydro-2H-pyrazinopyrrolo[2,3-b]indole-1,4-dione and cinnabarinic acid fragments of these marine al
87 3,4-g]thieno[3,2-c]isoquinoline-5,11(4H,10H)-dione and fluorenedicyclopentathiophene dimalononitrile,
88 A new class of pyrazolo[3,4-c]pyridine-3,7-dione and pyrazolo[3,4-d]azepine-3,7-dione scaffolds was
90 activation-arylation of pyridopyrimidin-2,4-diones and barbituric acids, respectively, with boronic
91 lectrochemical synthesis of pyrazolidine-3,5-diones and benzoxazoles by N-N bond formation and C,O li
92 reaction of 1,3,5-trisubstituted pentane-1,5-diones and substituted pyrazoles afforded good yields of
95 ylpiperazin-1-yl)-1,4-dihydronaphthalene-1,4-dione) and idebenone, which show modest whole-cell activ
97 (4-bromobenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione) and tandem conjugate reduction-selective monoredu
98 henyl)-furan-2-ylmethylene]-thiazolidine-2,4-dione) and TGX221(7-methyl-2-(4-morpholinyl)-9-[1-(pheny
99 10)-trien-17-yl]amino}hexyl)-1H-pyrrole-2,5- dione), and recovery from inhibition is prevented by wor
101 moieties (a modified lactide, morpholine-2,5-dione, and caprolactone), which under a tin-mediated rin
102 alcohols, phenols, 2-hydroxynaphthalene-1,4-dione, and indoles allow the direct and efficient synthe
103 ethoxy-2-(methylthio)cyclohexa-2,5-diene-1,4-dione, and the blue compound was determined to be 5-meth
105 s of Meldrum's acid derivatives, pyrrole-2,3-diones, and pyrrole-2-carboxylic esters, producing the e
106 rin, a potent tetracyclic aminoquinoline-5,8-dione antitumor antibiotic that reached phase II clinica
108 2,3-dihydro-2-alkoxy-indeno[1,2-b]pyrano-4,5-diones are labile compounds since through an opening of
109 H,3'H-[1,1'-bibenzo[c] thiophenylidene]-3,3'-dione, are found to fluoresce in their neat solid phases
110 estane, 6-methylideneandrosta-1,4-diene-3,17-dione, are preeminent drugs for the treatment of estroge
111 he discovery of the 3-hydroxyquinazoline-2,4-dione as a useful scaffold to obtain potent inhibitors o
112 ort herein the discovery of isoquinoline-1,3-dione as a viable chemotype for selectively inhibiting T
113 The first use of vicinal diols, ketols, or diones as 22pi components in metal-catalyzed [2+2+2] cyc
116 2,2,2- trifluoroethyl)butyl]thiazolidine-2,4-dione} as the optimal agent, which exhibited high antitu
117 Modeling of the substrate 4-androstene-3,17-dione at the position of the product revealed its intera
118 oxazolidin-2-one, 2-pyridone, pyrimidine-2,4-diones (AZT derivatives), or inosines to the electron-de
119 : 1-(2-benzoic acid)-(1H,3H)-quinazoline-2,4-dione (BaQD), 1-(2-benzoic acid)-(1H,3H)-quinazoline-2-o
120 We designed and synthesized quinazolin-2,4-dione-based hydroxamic acids to serve as selective compe
121 ituted naphthalene-1,4-diols and naphtha-1,4-diones bearing a phosphonate group at the 2-position and
123 H-indol-3-yl)-4-(benzofuran-3-yl)pyrrole-2,5-dione (BIP-135), efficiently abolished the inhibitory ef
124 yl-1H-pyrrolo[2,3-c]py ridin-3-yl)ethane-1,2-dione (BMS-585248, 12m) exhibited much improved in vitro
125 ibitors represented by the benzothiazole-4,7-dione, BN82685, block the second of two trans-esterifica
126 d 1-(2-benzaldehyde)-(1H,3H)-quinazoline-2,4-dione (BQD) in developing zebrafish (Danio rerio) embryo
127 esponding 2-hydroxy-1,2-dihydroquinoline-3,4-diones, but was unable to inactivate the PQS precursor H
128 tion of the steroid Delta(5)-androstene-3,17-dione by the glutathione transferase A3-3 in mammals was
129 ing group in the chromeno[3,4-c]chromene-6,7-diones caused a significant red shift in both the absorp
132 or antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) acted on RGCs to reduce On responses of gan
133 injection of 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and (2R)-amino-5-phosphonovaleric acid (AP-
135 or antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), whereas this drug had no effect on FGM.
136 yl)amino)ethylidene)-5-phenylcyclohexane-1,3-dione (compound 16c) with an IC50 = 0.09 +/- 0.01 muM in
139 and 3-phenyl-2H-benzo[e][1,3]oxazine-2,4(3H)-diones could be potential lead compounds for the develop
141 s(2-hydroxyphenyl)-3,4-diphenylhex-3-ene-1,6-dione (D1) and (Z)-2,2'-(1,2-diphenylethene-1,2-bis(benz
142 elling with 4-(3-azidopropyl)cyclohexane-1,3-dione (DAz-2) shows that Cys420 also forms a sulfenic ac
144 (3alpha,5alpha)-3-hydroxypregn-16-ene-11,20-dione (Delta(16)-alphaxalone) is explained by the steroi
145 ol-5-yl]-1,3-dipropyl-3,7-dihydro-purine-2,6-dione derivative 66: K(i) A(2B) = 9.4 nM, IC(50) hA(2B)
146 anded on a series of pyrido[2,1-f]purine-2,4-dione derivatives as human adenosine A3 receptor (hA3R)
147 and 3-phenyl-2H-benzo[e][1,3]oxazine-2,4(3H)-dione derivatives as potential antiosteoclastogenic agen
148 ormed on pyranopyrazole and pyranopyrimidine-dione derivatives to obtain spirocyclopropylpyrazolones
151 stituted 6-hydroxy-1,2,4-triazine-3,5(2H,4H)-dione derivatives were synthesized as inhibitors of D-am
155 ese were an androgen, 5alpha-androstane 3,17-dione, detected as the strongest enhancer of the pkd2 ph
156 concentrations of 3,4-dihydroxy-3-hexen-2,5-dione (DHHD) and 2,3-dihydro-3,5-dihydroxy-6-methyl-4(H)
157 droepiandrosterone, Delta(4)-androstene-3,17-dione, dihydrotestosterone, all P < .001; testosterone,
158 reaction of 1,3-di(pyridin-2-yl)propane-1,3-dione dioxime (dpdH2) with triangular [Mn(III)3O(O2CMe)(
159 en 3-phenyl-1,5-bis(pyridin-2-yl)pentane-1,5-dione dioxime (pdpdH(2)) and triangular [Mn(III)(3)O(O(2
160 and synthesis of a series of anthracene-9,10-dione dioxime series of compounds demonstrated potent in
161 honooxy)prop yl-1-(2-propynyl)-1H-purine-2,6-dione disodium salt hydrate), in modulating cocaine- and
162 ) reaction provides 1,2,4-dithiazolidine-3,5-diones [dithiasuccinoyl (Dts)-amines] by the rapid react
163 2-dodecyl-6-methoxycyclohexa-2,5-diene- 1,4-dione (DMDD) remarkably inhibited the growth of human br
164 2-Dodecyl-6-methoxycyclohexa-2, 5-diene-1,4-dione (DMDD), which was extracted from the root of Averr
165 hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione (DMDM), sodium hydroxymethylglycinate (SMG), 2-(hy
166 eaction with chalcones to give 2-benzoyl-1,4-diones (double aroylation products), which, in turn, wer
169 E)-3H,3'H-[1,1'-biisobenzofuranylidene]-3,3'-dione, (E)-3-(3-oxobenzo[c] thiophen-1(3H)-ylidene)isobe
170 on-donating group, cyclopenta[c]thiophen-4,6-dione electron acceptor and various pi-linkers including
171 rotestosterone, and Delta(4)-androstene-3,17-dione elucidated the structural basis for this functiona
172 tension of the substrate scope to cyclic 1,3-dione equivalents, such as 2-cyanocyclohexanone (4), is
173 with 4-ferrocenylmethyl-1,2,4-triazoline-3,5-dione (FMTAD): once derivatized, the determination of 25
174 allow the generation of benzocyclobutene-1,2-dione from 2-diazo-1,3-indandione because of the difficu
175 [4,5]pentaleno[1,6a-b](thia)pyrrolizine-6,12-diones from accessible 1,5-di(het)arylpent-4-ene-1,3-dio
178 An efficient synthesis of pyridopyrazine-1,6-dione gamma-secretase modulators (GSMs) is described.
179 lyzed bond scission of pentafluorobutane-1,3-diones generates difluoroenolates that react with aldehy
180 t IBMX and other oxypurines containing a 2,6-dione group interfere with the binding of glutamate to t
181 by the antagonist 6,7-dinitroquinoxaline-2,3-dione had no effect in the PGE2-induced hyperalgesia in
182 azo[1,2-a]pyridin-3-yl)pyrimidine-2,4(1H,3H)-diones has been accomplished based on a one-pot multicom
185 ino-2-phenylthieno[3,2-c]pyridine-4,6(5H,7H)-dione), has a long plasma half-life (~ 24 hours) in mice
186 trahydro-1H-pyrrolo[1,2-c]imidazol e-1,3(2H)-dione] has been characterized as a high-affinity and pot
188 a novel variant of 2-hydroxyisoquinoline-1,3-dione (HID) scaffold featuring a crucial C-6 benzyl or b
191 previously reported 3-hydroxypyrimidine-2,4-dione (HPD) core, we have designed and synthesized a new
192 reviously reported a 3-hydroxypyrimidine-2,4-dione (HPD) subtype that potently and selectively inhibi
193 tions of three novel 3-hydroxypyrimidine-2,4-dione (HPD) subtypes carefully designed to achieve selec
194 l and 1-alkyl 2,2,4,4,4-pentafluorobutan-1,3-dione hydrates has been used to produce a series of pent
197 irradiation of N-methyl-1,2,4-triazoline-3,5-dione in the presence of substituted benzenes is capable
202 shira cross-coupling reactions of cyclic 1,3-diones in the synthesis of beta-substituted cyclic enone
203 thin (3,3'-dihydroxy-beta,beta-carotene-4,4'-dione) in the blood-red flowers of Adonis aestivalis, an
204 )-6-(4-hydroxy-3-methoxyphenyl)hex-5-ene-2,4-dione) in the curcumin degradation process has not been
206 prochiral 2,2-disubstituted cyclopentene-1,3-dione is catalyzed by a bifunctional tertiary aminourea
210 emestane (6-methyleneandrosta-1,4-diene-3,17-dione) is a synthetic steroidal inhibitor of the aromata
211 ydroxy-3-methoxy-phenyl)-hepta-1,6-diene-3,5-dione, is a polyphenolic compound naturally present in t
212 -hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione] is a natural plant phenolic compound that possess
213 roline, and the cyclic ketones 1H-indole-2,3-dione (isatin), indenoquinoxaline-11-one and acenaphthen
214 utoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145), was synthesized and biologically character
215 of (E)-3-arylidene-1-phenyl-pyrrolidine-2,5-diones, l-proline, and the cyclic ketones 1H-indole-2,3-
217 ), where phendione = 1,10-phenanthroline-5,6-dione, leads to DNA cleavage in an oxygen independent ma
219 dy provides evidence that higher levels of 4-dione may be associated with lower, and SHBG with higher
220 ,6-pentachloro-6-hydroxy-cyclohexa-2-ene-1,4-dione may serve as a key branching point, with chloramin
221 lidene)dihydro-2-thioxopyrimidine-4,6(1H,5H)-dione (MDG 548), 3-((4-bromophenoxy)methyl)-N-(4-nitro-1
222 he reaction of N-methyl-1,2,4-triazoline-3,5-dione (MeTAD) with acenaphthylene and indene leads not o
223 he reaction of N-methyl-1,2,4-triazoline-3,5-dione (MeTAD) with anisole in the presence of trifluoroa
224 g 5-(pyridin-2-ylmethylene)imidazolidine-2,4-dione moieties has been synthesized in three steps.
225 unprecedented 3,4-dihydro-1-benzazepine-2,5-dione-N-prenyl-N-acetoxy-anthranilamide scaffold, was is
226 4-methoxyphenyl)-4-morpholino-1H-pyrrole-2,5-dione, named RI-2 (referred to as compound 7a in this re
227 -6-nitro-7-sulfamoyl-benzo(f)quinoxaline-2,3-dione (NBQX) to block enhanced AMPA receptor glutamaterg
228 (naphthalene-1-yl)-1,2,4-thiadiazolidine-3,5-dione (NP12), lessens the magnitude of adverse myocardia
230 -(1,3-dihydroxyallylidene)-1H-indene-1,3(2H)-dione or by loss of alcohol to indeno[1,2-b]pyran-4,5-di
231 rom accessible 1,5-di(het)arylpent-4-ene-1,3-diones or curcuminoids in 38-98% yield was developed.
233 ocarbons across the diol, hydroxyketone, and dione oxidation levels to form products of [4 + 2] cyclo
234 accessible from the diol, alpha-ketol or 1,2-dione oxidation levels with complete control of diastere
235 with a catalytic mechanism involving olefin-dione oxidative coupling to form an oxa-osmacyclopentane
236 clo[2.2.1]heptane-2,4'-[1,2]dioxolane]-3',5'-dione (P4) can be effectively used for the syn-dihydroxy
237 :4,5-b']dithiophene-thieno[3,4-c]pyrrole-4,6-dione) (PBDTTPD) polymers for bulk heterojunction (BHJ)
238 o[2,3-c:9,10-c']bis([1,2,5]thiadiazole)-6,13-dione (PBTDQ), with two peripheral thiadiazole rings was
239 The 6-hydroxy-1,2,4-triazine-3,5(2H,4H)-dione pharmacophore appears metabolically resistant to O
240 st system, employing 1,10-phenanthroline-5,6-dione (phd) as the ancillary ligand, that enables aerobi
241 ing the redox active 1,10-phenanthroline-5,6-dione (phendione) ligand by electrochemical functionaliz
244 3,4-g]thieno[3,2-c]isoq uinoline-5,11(4H,10H-dione) (PNSW); poly(4,10-bis(2-butyloctyl)-2-(5-(2-ethyl
245 ,4-g]thieno[3,2-c]isoquinoline-5,11(4H, 10H)-dione) (PNTPD); poly(5-(4,10-bis(2-butyloctyl)-5,11-diox
246 :4,5-b']dithiophene-thieno[3,4-c]pyrrole-4,6-dione polymers (PBDTTPD derivatives) was synthesized and
247 how that 2-pyridine-3-yl-methylene-indan-1,3-dione (PRT4165) is a potent inhibitor of PRC1-mediated H
248 of ABCDs with 4-phenyl-1,2,4-triazoline-3,5-dione (PTAD) catalyzed by Yb(OTf)(3) also results in the
249 anhydride and 4-phenyl-1,2,4-triazoline-3,5-dione (PTAD) to determine the kinetics and mechanisms of
250 17,21-Dimethyl-19-norpregna-4,9-dien-3,20-dione (R5020) progestin limited this effect and was coun
251 hyl acetate, ethyl octanoate, and butane-2,3-dione) representative of the four chemical classes.
252 xystyryl)-7-methyl-3,7-dihydro-1H-purine-2,6-dione], respectively, in squirrel monkeys trained to int
254 roviding the dibenzo[b,f][1,4]-dioxocin-6,11-dione ring-system, which is otherwise difficult to prepa
256 fused dihydro[1,3]dithiolo[4,5-c]pyrrole-4,6-dione rings interconnected by 3,5-diylidenethiomorpholin
258 ased on the 1 H,3 H-pyrido[2,1- f]purine-2,4-dione scaffold, a series of ligands bearing a fluorosulf
259 ubstitutions of the indeno[1,2-b]indole-9,10-dione scaffold, potent CK2 inhibitors into selective ABC
260 ine-3,7-dione and pyrazolo[3,4-d]azepine-3,7-dione scaffolds was synthesized via a Michael addition a
261 ructure with bound product 4-androstene-3,17-dione showed that Ser-468 is in a position in which it c
262 iscovery of 1,3,8-triazaspiro[4.5]decane-2,4-diones (spirohydantoins) as a structural class of pan-in
264 effective use of furan as a E-but-2-ene-1,4-dione surrogate, Nagao acetate aldol reaction, and Shiin
265 ion of the tricyclic naphtho[2,3-b]furan-4,9-dione system were synthesized and evaluated for their ab
266 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione (TDZD-8) restored Schwann cell defects, effectivel
267 elective inhibitors using similar indole-2,3-diones that exhibit differential inhibition of ALDH1A1,
268 phenanthro[1,10,9,8,o,p,q,r,a]per ylene-7,14-dione), the fluorescent, lipophilic pigment associated w
269 ndol-3-yl]-4-(1H-indol-3-yl)-1H-pyr role-2,5-dione), the PKCbeta-selective inhibitor Ruboxastaurin, a
270 zol-2-ylthio)-6-tosylcyclohexa-2,5-diene-1,4-dione through a Michael-type addition of p-toluenesulfin
271 ostene-3,17-dione and 5alpha-androstane-3,17-dione to testosterone (T) and 5alpha-dihydrotestosterone
272 accessible 2-(2-bromobenzyl)cyclohexane-1,3-diones to provide the corresponding 2,3,4,9-tetrahydro-1
273 version of the synthesized xanthen-2,9(4a H)-diones to xanthones by treatment with sodium dithionite
274 proved synthesis of thieno[3,4-c]pyrrole-4,6-dione (TPD) monomers, including Gewald thiophene ring fo
276 from different chemical families (penta-2,3-dione, trans-2-hexen-1-al, ethyl hexanoate, nonan- and d
277 e compound (z)-5-octylidenethiazolidine-2, 4-dione (TZD-C8) was a strong inhibitor of biofilm formati
278 3-triazole and 4-phenyl-1,2,4-triazoline-3,5-dione undergo a formal Diels-Alder reaction, which follo
280 ,6-pentachloro-6-hydroxy-cyclohexa-2-ene-1,4-dione via chlorophenol and chlorobenzoquinone intermedia
281 responding benzazine-3-ones or benzazine-2,3-diones via the 6-exo-trig process in compliance with Bal
285 ctionalized beta-lactams and pyrrolidine-2,5-diones was achieved through a sequential Ugi-4CR/cycliza
286 in the concentration of 4-androstenedione (4-dione) was associated with a 50% decreased LC risk (OR =
287 azolidine-2,4- dione (2), a thiazolidine-2,4-dione, was obtained from a high throughput screening of
288 g the oxacarbenium ion, novel pyrimidine-2,4-diones were synthesized and evaluated as inhibitors of h
289 hoxymethyl)-5-isopropylpyrimidine-2,4(1H,3H)-dione) were synthesized by reaction of 6-[(3,5-dimethylp
290 -5-nitrobenzylidene)-3-ethylthiazolidine-2,4-dione, were utilized to gain insight into the structure-
291 osphooxy)propyl-1-(2 propynil)-1H-purine-2,6-dione] were found previously to either decrease or incre
292 2,2,4-tribromo-5-hydroxy-4-cyclopentene-1,3-dione, which is an analogue to several previously descri
295 ies of 7-amino- and 7-acetamidoquinoline-5,8-diones with aryl substituents at the 2-position were syn
296 d produced 5,5-disubstituted oxazolidine-2,4-diones with the formation of a C-O bond in moderate to e
300 system consisting of 1,10-phenanthroline-5,6-dione/ZnI2 that bypasses these constraints via an abiolo