ライフサイエンスコーパス: dioxolane

1 does not lead to benzoin but to a stable 1,3-dioxolane.

2 l muscarinic agonists oxotremorine-M and cis-dioxolane.

3 noxysilanes and yielding 1,2-dioxanes or 1,2-dioxolanes.

4 tions between the bilayers and the SS and RR dioxolanes.

5 rial activities and ADME profiles of the 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane isoste

6 alization of the amine carboxylate salt of l-dioxolane 10 provides enantiomerically pure l-dioxane 11

7 ical methodology for both chiral pure l- & d-dioxolane 11 and 13 were developed via diastereomeric ch

8 activated charcoal to form 5-substituted-1,3-dioxolane-2,4-diones in 90-100% yield.

9 The 1,3-dioxolane-2-phosphenium ion, 1,3-benzodioxole-2-phosphen

10 h is modeled on 3,5-dimethyl-5-hexadecyl-1,2-dioxolane-3-acetic acid (1a), an unnamed natural product

11 The first asymmetric synthesis of 1,2-dioxolane-3-acetic acids is reported.

12 roxide spiro[bicyclo[2.2.1]heptane-2,4'-[1,2]dioxolane]-3',5'-dione (P4) can be effectively used for

13 II), the predominant reaction course for 1,2-dioxolane 3a was two-electron reduction.

14 be polymerised with (4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-dicarbonyl dichloride to give a polymer th

15 ric acid derivative (4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-dicarbonyl dichloride to obtain new materi

16 hol, alpha,alpha,alpha',alpha'-tetraaryl-1,3-dioxolane-4,5-dimethanol (TADDOL), catalyzes the all-car

17 TADDOL=alpha,alpha,alpha,alpha-tetraaryl-1,3-dioxolane-4,5-dimethanol).

18 ne}succinate and (R)-2,2,5,5-tetramethyl-1,3-dioxolane-4-carbaldehyde, facile synthesis of (-)-epi-cl

19 ral primary alcohol (R)-(-)-2,2-dimethyl-1,3-dioxolane-4-methanol to the corresponding trichloromethy

20 d glycerol moiety, (S)-(+)-2, 2-dimethyl-1,3-dioxolane-4-methanol, allowed the selective crystallizat

21 metal surface with poly((N-2,2-dimethyl-1,3-dioxolane-4-methyl)-5-norbornene-exo-2,3-dicarboximide),

22 romovinyl)-1-((2S,4S)-2-(hydroxymethyl)-1,3-(dioxolane-4-yl) uracil (l-BHDU, 17) is a potent and sele

23 romovinyl)-1-((2S,4S)-2-(hydroxymethyl)-1,3-(dioxolane-4-yl))uracil (l-BHDU, 1), which had significan

24 demethylation to produce corresponding (1,3-dioxolane-4-yl)-1,4-benzoquinones.

25 rmore, series of other isoprostanes, such as dioxolane A(2), D(2), E(2), etc., can be derived from th

26 ydroxy-9,11-dioxolane eicosatetraenoic acid (dioxolane A3, DXA3).

27 des with acetone to prepare 2,2-dimethyl-1,3-dioxolanes (acetonides) in good to excellent yields.

28 es a novel stereoselective photochemical 1,3-dioxolane addition to 5(S)-benzyloxymethyl-2(5H)-furanon

29 atic interactions between the oxygens in the dioxolane and adjacent carbonyls in the R,R-dioxolane-li

30 For comparison, pure dioxolane and dioxane ions were generated from tailor-ma

31 sis for the utilization of C-C bound ribose, dioxolane and dioxane moieties in the generation of impr

32 yl diazomalonate, competition exists between dioxolane and epoxide formation so that with p-anisaldeh

33 As dioxolane and oxathiolane nucleosides have exhibited pro

34 dy the formation of protonated five-membered dioxolane and six-membered dioxane rings and show that d

35 ive synthesis of a broad range of chiral 1,2-dioxolanes and 1,2-dioxanes, thereby facilitating biolog

36 gold(I)-catalyzed ring-opening of cyclic 1,3-dioxolanes and dioxanes by trimethylsilyl alkynes to set

37 ones or aldehydes into the corresponding 1,3-dioxolanes and the carboxyl group of benzoate ester into

38 ing 4-hydroperoxy-2-alkanols to 3-alkoxy-1,2-dioxolanes, and Lewis acid mediated homologation of the

39 e electron-donating groups 4-methoxy and 1,3-dioxolane are preferred at P2' phenyl ring, as compounds

40 ketones caged as 4-(2,5-dihydroxyphenyl)-1,3-dioxolanes are efficiently (Phi = 0.1-0.2) released in a

41 r the acetal oxygen of 2-(4-nitrophenyl)-1,3-dioxolane bound by an artificial enzyme.

42 Replacing the S,S-dioxolane by an S,S-cyclopentane had no effects on the g

43 ose unit is rearranged into an unprecedented dioxolane (cis-bicyclo[3.3.0]-2',4',6'-trioxaoctan-3'bet

44 thia-CMP > beta-L-2',3'-dideoxy-CMP > beta-L-dioxolane-CMP.

45 d of l-lactide homopolymer and l-lactide/1,3-dioxolane (co)polymers loaded with quercetin (Q) were fa

46 Beta-L-(-)-dioxolane cytidine [(-)-OddC] is the first nucleoside an

47 well as L-nucleoside analogs such as beta-L-dioxolane-cytidine (L-OddC), beta-L-2',3'-dideoxy-3'-thi

48 beta-l-Dioxolane-cytidine (l-OddC, BCH-4556, Troxacitabine) is

49 Beta-L-dioxolane-cytidine (L-OddC, BCH-4556, Troxacitabine), a

50 beta-L-Dioxolane-cytidine (L-OddC, Troxacitabine, BCH-4556), a

51 at the in vivo therapeutic efficacy of l-1,3-dioxolane-cytidine against solid tumors may be improved

52 ctivity on matched, 3' mispaired, and beta-l-dioxolane-cytidine nicked DNA are 2.3, 61.2, and 98.8 mi

53 d, 3' mispaired, or nucleoside analog beta-l-dioxolane-cytidine terminated nicked DNA as well as for

54 l-1,3-Dioxolane-cytidine, a potent anticancer agent against le

55 antly improved antitumor activity over l-1,3-dioxolane-cytidine.

56 Sufficient amounts of synthetic 26-dioxolane dEpoB were produced using this sequence for an

57 D- and L-Oxathiolane and -dioxolane derivatives 13, 16, 20, 21, and 29-34 were pre

58 leading to the synthesis of 4-methylene-1,3-dioxolane derivatives.

59 ture-activity relationship studies of l- & d-dioxolane-derived nucleosides.

60 two of them, the linker was the conventional dioxolane described previously (SS and RR channels).

61 rs, however, proton affinities of gA and the dioxolane-dimer were significantly lower (K(D) of approx

62 ) particles dispersed in a polymerizable 1,3-dioxolane (DOL) liquid.

63 sence of Lewis acid salts, the cyclic ether, dioxolane (DOL), is known to undergo ring-opening polyme

64 oposes a dioxolane structure, 8-hydroxy-9,11-dioxolane eicosatetraenoic acid (dioxolane A3, DXA3).

65 ously proposed a structure of 8-hydroxy-9,11-dioxolane eicosatetraenoic acid (DXA(3)).

66 yclic peroxides, bicyclic endoperoxides, and dioxolane-endoperoxides.

67 ting groups with traditional 1,3-dioxane/1,3-dioxolane for carbonyl compounds.

68 e Rh-catalyzed method for the preparation of dioxolanes from alpha-alkyl-alpha-diazoesters.

69 stage Noyori acetalization incorporated the dioxolane functionality.

70 The chemistry works specifically on dioxolane-fused systems or close variants, and substitut

71 were covalently linked with a novel modified dioxolane group containing a retinal attachment (ret-SS

72 The direct role of the dioxolane group on the gating and single-channel conduct

73 2,6-diaminopurine dioxolane), the prodrug of dioxolane guanosine (DXG), is currently in phase I/II cl

74 anscriptase-catalyzed viral DNA synthesis by dioxolane guanosine 5'-triphosphate (DXG-TP), 3'-azido-3

75 Consistent with previous data, both dioxolanes had very weak antimalarial properties.

76 unctional consequence of the flipping of the dioxolane inside the pore of the channel.

77 olanyluracil analogues was prepared from the dioxolane intermediates 2, and their anti-Epstein Barr v

78 lycosylation reaction of the oxathiolane and dioxolane intermediates with silylated uracil analogues

79 1,3-Dioxolane is converted to its radical species in the pre

80 mical reactions by production of dioxane and dioxolane isomers, furfural and 5-hydroxymethylfurfural,

81 series can be further oxidized to form novel dioxolane-IsoP-like compounds, analogous to those genera

82 ), D(2), E(2), etc., can be derived from the dioxolane-isoprostane peroxides.

83 A novel class of peroxides (termed dioxolane-isoprostanes) having a bicyclic endoperoxide m

84 Nonperoxidic 1,3-dioxolane isosteres of 3 were inactive as were trioxolan

85 s seems to depend on the conformation of the dioxolane link between gA's.

86 In contrast, for the dioxolane linked gA dimers, E(a) values were strongly mo

87 us measurements obtained in the S,S- and R,R-dioxolane-linked as well as in native gA channels.

88 ayer used in this study, both the SS- and RR-dioxolane-linked channels opened in a mode of bursting a

89 dioxolane and adjacent carbonyls in the R,R-dioxolane-linked gA channel attenuate the rate of H(+) t

90 ), and in the SS- and RR-diastereoisomers of dioxolane-linked gA channels (SS and RR channels).

91 gA) and in the SS and RR diastereoisomers of dioxolane-linked gA channels in planar bilayers.

92 lyceride bilayers on proton transfer in both dioxolane-linked gA channels must relate to distinct int

93 d in two diastereoisomers (SS and RR) of the dioxolane-linked gA channels were measured in glycerylmo

94 ne are considerably larger than those in R,R-dioxolane-linked gA channels.

95 The RR dioxolane-linked gA dimer "inactivated" in GMO/decane bu

96 Dioxolane-linked gA dimers formed ion channels, selectiv

97 n A (gA) and in covalently linked SS- and RR-dioxolane-linked gA proteins.

98 onductance of different stereoisomers of the dioxolane-linked gramicidin A (gA) channels reconstitute

99 Two different stereoisomers of the dioxolane-linked gramicidin A (gA) channels were individ

100 uctance (g(H)) in single SS stereoisomers of dioxolane-linked gramicidin A (gA) channels were measure

101 The mobility of protons in a dioxolane-linked gramicidin A channel (D1) is comparable

102 (g(H)) in two different stereoisomers of the dioxolane-linked gramicidin A channel (the SS and RR dim

103 As in HCl, the presence of a retinal in the dioxolane linker did not affect the gating behavior of t

104 nd hydrophobic retinal group immobilizes the dioxolane linker in the bilayer core preventing its rota

105 arise from different chiralities within the dioxolane linker.

106 A novel series of benzo-1,3-dioxolane metharyl derivatives was synthesized and evalu

107 The 2,2-dimethyl-1,3-dioxolane moiety also served as a protected form of a di

108 Using this method, we synthesize poly(1,3-dioxolane) (PDXL), which demonstrates tensile strength c

109 ety characteristic of the isoprostanes and a dioxolane peroxide functionality in the same molecule wa

110 ased on a perfluoro(2-methylene-4-methyl-1,3-dioxolane) (PFMMD) backbone.

111 served and with p-nitrobenzaldehyde only 1,3-dioxolane products are formed.

112 mine- and iodine-substituted 16alpha,17alpha-dioxolane progestins, some of which, when appropriately

113 s, (4) the constitution of the 4,5-fused 1,3-dioxolane ring (2, 54, 55, 63-68, 76, 77, 80, 83a-r, 84-

114 sults showed that the replacement of the 1,3-dioxolane ring by a tetrahydrofuran, cyclopentanone, or

115 e that the stereochemical orientation of the dioxolane ring is important for both potent Hh pathway i

116 4) The dioxolane ring is probably responsible for the closing f

117 n as to the optimal configuration around the dioxolane ring of the ITZ scaffold.

118 holines via a tandem reductive vinyl dioxane/dioxolane ring opening and alkyliodide coupling process

119 hat in platelets, the lipid likely forms via dioxolane ring opening with rearrangement to the diepoxy

120 (gA) molecules were covalently linked with a dioxolane ring.

121 iviral activity profile is the presence of a dioxolane ring.

122 and six-membered dioxane rings and show that dioxolane rings are predominant throughout different gly

123 verse array of highly dense exomethylene 1,3-dioxolane rings demonstrating a remarkable tolerance for

124 nd 4, 5-fused (30-38, 43, 45-47, 52, 53) 1,3-dioxolane rings, (4) the constitution of the 4,5-fused 1

125 2-(1,1-Dimethylethyl)-2-(4-methylphenyl)[1,3]dioxolane (SAH51-641, 1) has previously been demonstrate

126 Detailed characterization proposes a dioxolane structure, 8-hydroxy-9,11-dioxolane eicosatetr

127 In the biphenyl and dioxolane systems, the reactions proceed with surprising

128 d cycloalkyl groups to the central benzo-1,3-dioxolane template were found to be potent and selective

129 talyzed cyclization of enynols, alpha-alkoxy dioxolane-tethered 1,3-enynes exclusively undergo bis-ox

130 Amdoxovir ((-)-beta-D-2,6-diaminopurine dioxolane), the prodrug of dioxolane guanosine (DXG), is

131 1,3-Dioxolane, THF, dimethoxyethane, hexamethylphosphoramide

132 through selective 2-functionalization of 1,3-dioxolane through nickel and photoredox catalysis.

133 Hydrogen atom transfer from 1,3-dioxolane to a-malonyl radicals is corroborated by exper

134 ort for the first time that 18 saponins with dioxolane-type (2 saponins) and acetal-type (16 saponins

135 thesize ultra-high-molecular-weight poly(1,3-dioxolane) (UHMW pDXL), a chemically recyclable thermopl

136 lon-dihydroxy-beta-amino ester bears a trans-dioxolane unit, cyclization occurs upon attack of the al

137 silon-dihydroxy-beta-amino ester bears a cis-dioxolane unit, cyclization occurs upon attack of the be

138 ictated by the relative configuration of the dioxolane unit.

139 esters (beta-substituted with cis- and trans-dioxolane units) coupled with in situ enolate oxidation

140 The potency of L-dioxolane uracil nucleosides against EBV replication is

141 carbonyl compounds to the corresponding 1,3-dioxolane using ethylene glycol is also catalyzed by Bi(

142 ewis acid-mediated allylation to furnish 1,2-dioxolanes via attack of hydroperoxide on the intermedia

143 The 1,2-dioxolanes were either inactive or orders of magnitude l

144 Fourteen spiro- and dispiro-1,2-dioxolanes were synthesized by peroxycarbenium ion annul

145 aphy for the synthesis of chiral pure l- & d-dioxolane, which offers avenues for the development and

146 th aromatic aldehydes gives tetrasubstituted dioxolanes with unusually high diastereoselectivity.