ライフサイエンスコーパス: dioxygenase

1 TG601A), a strain that overexpresses toluene dioxygenase.

2 gh not in vivo) inhibitor of indoleamine 2,3-dioxygenase.

3 ally, this involves TET1, a 5-methylcytosine dioxygenase.

4 t hydroxylase, Rieske dioxygenase, and thiol dioxygenase.

5 quence similarity to 4-hydroxyphenylpyruvate dioxygenase.

6 tes ten-eleven translocation enzyme 3 (TET3) dioxygenase.

7 tion of translation of the homogentisate 1,2-dioxygenase.

8 anding of LsdA and related stilbene-cleaving dioxygenases.

9 a double knockout (DKO) of the Tet1 and Tet2 dioxygenases.

10 ha-ketoglutarate (alpha-KG)/Fe(II)-dependent dioxygenases.

11 serving as a cofactor for TET methylcytosine dioxygenases.

12 ggests an ancient developmental role for Tet dioxygenases.

13 haracteristic of an Fe(II)/alphaKG-dependent dioxygenases.

14 oxyglutarate affect 2-oxoglutarate-dependent dioxygenases.

15 wledge of the substrate specificity of thiol dioxygenases.

16 specific fate programs via alphaKG-dependent dioxygenases.

17 sensing via non-heme iron(Fe(2+))-dependent-dioxygenases.

18 to binding behaviors observed in other thiol dioxygenases.

19 mes are 2-oxoglutarate- and Fe(II)-dependent dioxygenases.

20 tatic control mechanism mediated by cysteine dioxygenase 1 (CDO1), which catalyzes the irreversible m

21 Human indoleamine 2,3-dioxygenase 1 (hIDO1) and human tryptophan dioxygenase (

22 Indoleamine 2,3-dioxygenase 1 (hIDO1) and tryptophan dioxygenase (hTDO)

23 Human indoleamine 2,3-dioxygenase 1 (hIDO1) is an attractive cancer immunother

24 Indoleamine 2, 3-dioxygenase 1 (IDO) catalyzes 1 rate-limiting step of L-

25 etroviral ISGs indicate that indoleamine 2,3-dioxygenase 1 (IDO1) can inhibit retroviral replication

26 Indoleamine 2,3-dioxygenase 1 (IDO1) catalyzes the rate-limiting step in

27 yptophan metabolizing enzyme indoleamine 2,3-dioxygenase 1 (IDO1) in the intestinal epithelium.

28 Indoleamine 2,3-dioxygenase 1 (IDO1) is a single chain oxidoreductase th

29 yptophan-metabolizing enzyme indoleamine 2,3 dioxygenase 1 (IDO1) is frequently overexpressed in epit

30 e (Kyn), the main product of indoleamine 2,3-dioxygenase 1 (IDO1) that catalyzes the rate-limiting st

31 ri induces the expression of indoleamine 2,3-dioxygenase 1 (IDO1) through the nucleotide oligomerizat

32 Indoleamine 2,3-dioxygenase 1 (IDO1), promoting immune escape of tumors,

33 renine pathway by the enzyme indoleamine 2,3-dioxygenase 1 (IDO1), which is induced by IFNgamma(3-5).

34 ry T-cells (Tregs), CD47 and indoleamine 2,3-dioxygenase 1 (IDO1).

35 ibed as potent inhibitors of indoleamine 2,3-dioxygenase 1 (IDO1).

36 binding protein 1 (YB-1) and methylcytosine dioxygenase 1 (Tet1), bind to BDNF chromatin in naive bu

37 an catabolism by the enzymes indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase 2 (IDO/TDO)

38 However, whether indoleamine 2,3-dioxygenase 1 forms (1)O(2) and whether this contributes

39 Here we show that arterial indoleamine 2,3-dioxygenase 1 regulates blood pressure via formation of

40 y of dioxygenases, including indoleamine 2,3-dioxygenase 1(5).

41 programmed cell death 1, and indolamine 2,3-dioxygenase 1), corresponding to higher frequency of som

42 Indoleamine 2,3-dioxygenase 1, a catabolic enzyme, and inhibitory ligand

43 m (CsNCED1, 9-cis-neoxanthin epoxycarotenoid dioxygenase 1, and CsCYP707A) rendering a significant ho

44 Indoleamine 2,3 dioxygenase-1 (IDO-1) is an enzyme in the kynurenine pat

45 Small-molecule inhibitors of indoleamine 2,3-dioxygenase-1 (IDO1) are emerging at the vanguard of exp

46 ort the discovery of a novel indoleamine 2,3-dioxygenase-1 (IDO1) inhibitor class through the affinit

47 mation-induced activation of indoleamine 2,3 dioxygenase-1 (IDO1).

48 ethyltransferase3A (DNMT3A-CD) or Ten-Eleven Dioxygenase-1 (TET1-CD) for loci-specific alteration of

49 G correlated positively with indoleamine-2,3-dioxygenase-1 enzyme activity, regulatory T-cell frequen

50 el of messenger RNA encoding indoleamine 2,3-dioxygenase-1 was significantly increased.

51 leamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase 2 (IDO/TDO) promotes immunosuppression acros

52 Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (PLOD2) encodes the only lysyl hydroxylase

53 slinker procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (PLOD2), in sarcomas has resulted in incre

54 The contribution of Tet methylcytosine dioxygenase 2 (TET2) and nuclear factor kappaB to DNA de

55 Tet methylcytosine dioxygenase 2 (Tet2) is an epigenetic regulator that rem

56 nsferase 3 Beta (DNMT3B), Tet methylcytosine dioxygenase 2 (TET2), and Thymine DNA glycosylase (TDG)

57 ion: ten-eleven translocation methylcytosine dioxygenase 2 (TET2).

58 The carotenoid cleavage dioxygenase 2, a new member of the CCD family, catalyzes

59 enzymes called 2-oxoglutarate (OG)-dependent dioxygenases (2-OGDDs), but they vary in their oxygen af

60 Somatic mutations of Tet-methylcytosine-dioxygenase-2 (TET2), a key enzyme in DNA demethylation,

61 ls of messenger RNAs encoding tryptophan 2,3-dioxygenase-2 and solute carrier family 6 member 19 (als

62 2-Oxoglutarate-dependent dioxygenases (2OGDDs) are a superfamily of enzymes that

63 with ten-eleven translocation methylcytosine dioxygenase 3 (TET3), a protein responsible for oxidatio

64 is-X-Asp, which is conserved in Fe-dependent dioxygenases(3).

65 change at CCD4b encoding CAROTENOID CLEAVAGE DIOXYGENASE 4b is a major genetic determinant of natural

66 tic genes DWARF27 (D27), CAROTENOID CLEAVAGE DIOXYGENASE 7 (CCD7) and CCD8 revealed that their transc

67 a pathway involving the Carotenoid Cleavage Dioxygenase 8 (CCD8).

68 shoot branching-related CAROTENOID CLEAVAGE DIOXYGENASE 8 gene was found to be significantly downreg

69 Lignostilbene-alpha,beta-dioxygenase A (LsdA) from the bacterium Sphingomonas pau

70 rate (Fe/alphaKG)-dependent aryloxyalkanoate dioxygenases (AADs).

71 pounds in E. polonica, initiated by catechol dioxygenase action, are important to the infection, grow

72 The proteins show similar NO dioxygenase activities in vitro, are nitrosylated in Cys

73 role of these metabolites in the control of dioxygenase activity and cell fate programs.

74 lfide bridge both defines the kinetics of NO dioxygenase activity and regulates appearance of the fre

75 ation in Tet that specifically abolishes the dioxygenase activity causes similar morphological and mo

76 We previously proposed that l-DOPA 4,5-dioxygenase activity evolved via a single Caryophyllales

77 onvergent acquisition of elevated l-DOPA 4,5-dioxygenase activity is consistent with recurrent specia

78 We find that low l-DOPA 4,5-dioxygenase activity is distributed across the DODA gene

79 We directly demonstrate that PCO dioxygenase activity produces Cys-sulfinic acid at the N

80 s chemical inhibition of carotenoid cleavage dioxygenase activity restored PLB formation in ccr2 etio

81 formations, there a few examples of apparent dioxygenase activity where both oxygen atoms are donated

82 yphyletic occurrences of elevated l-DOPA 4,5-dioxygenase activity, accompanied by convergent shifts i

83 The Cys/Ser mutation does not affect NO dioxygenase activity, and S-nitrosylation does not signi

84 The evolution of l-DOPA 4,5-dioxygenase activity, encoded by the gene DODA, was a ke

85 sed 23 distinct DODA proteins for l-DOPA 4,5-dioxygenase activity, from four betalain-pigmented and f

86 we then explored the evolution of l-DOPA 4,5-dioxygenase activity.

87 unctions have been put forward, including NO dioxygenase activity.

88 in HmpA, which has aerobic nitric oxide (NO) dioxygenase activity.

89 sly unrecognized oxidative activation of the dioxygenase activity.

90 Cysteamine dioxygenase (ADO) has been reported to exhibit two disti

91 assigned as cysteamine (2-aminoethanethiol) dioxygenase (ADO), as a low oxygen affinity (high-K (m)O

92 repair by the alpha-ketoglutarate-dependent dioxygenase AlkBH3.

93 ICU11 encodes a 2-oxoglutarate-dependent dioxygenase, an activity associated with histone demethy

94 ygb) functions as a potent nitric oxide (NO) dioxygenase and regulates NO metabolism and vascular ton

95 and function relationships of the heme-based dioxygenases and provide new guidelines for structure-ba

96 450 monooxygenases, 2-oxoglutarate-dependent dioxygenases and UDP-dependent glycosyltransferases pote

97 V. anguillarum hppD (4-hydroxyphenylpyruvate-dioxygenase), and a mutated hmgA produced brown colored

98 2-oxoglutarate-dependent hydroxylase, Rieske dioxygenase, and thiol dioxygenase.

99 pressed the immunomodulatory indoleamine-2,3-dioxygenase, and upregulated expression of genes charact

100 mediated by DC expression of indoleamine 2,3-dioxygenase, and was confirmed in IDO-KO mouse model.

101 these Fe(II) /alpha-ketoglutarate-dependent dioxygenases, and suggest activity on unexplored substra

102 oxygen-insertion mechanism of tryptophan 2,3-dioxygenases, and transformed tryptophan 2,3-dioxygenase

103 Acireductone dioxygenase (ARD) from the methionine salvage pathway (M

104 en-eleven translocation (TET) methylcytosine dioxygenases are enzymes that catalyze the demethylation

105 e models of cobalt-substituted ring-cleaving dioxygenases are presented.

106 c perturbation identifies DNA methylcytosine dioxygenase as an epigenetic barrier into the 2C-like ce

107 ion, via reversible inhibition of epigenetic dioxygenases, as well as posttranslationally, via covale

108 enome encodes for more than 60 2KG-dependent dioxygenases, assigning their individual functions remai

109 g cleavage that is performed by an extradiol dioxygenase (BbdF) producing 2,4,6-trioxoheptanedioic ac

110 cis-phytoene synthase, 9-cis-epoxycarotenoid dioxygenase, beta-carotene hydroxylase and carotene epsi

111 a competitive inhibitor of alphaKG-dependent dioxygenases) blunts p53-driven tumour suppression.

112 idase and (1H)-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase, both cofactor-independent enzymes that surm

113 metal-bound thiolate donors in nonheme thiol dioxygenases, but 2 does not lead to S-oxygenation of th

114 on, we identified a 2-oxoglutarate-dependent dioxygenase (BX13) that catalyzes the conversion of DIMB

115 Inhibition of 3-hydroxyanthranilate 3,4-dioxygenase by 6-chloro-dl-tryptophan prevented both inc

116 the Ten-eleven translocation (TET) family of dioxygenases can lead to demethylation.

117 Iron-(II)/alpha-ketoglutarate-dependent dioxygenases can oxidize 5mC to 5-hydroxymethylcytosine

118 entified in E. polonica that encode catechol dioxygenases carrying out these reactions.

119 adipic acid from catechol using catechol 1,2-dioxygenase (CatA) and a muconic acid reductase (MAR) in

120 f O(2), proving the product is the result of dioxygenase catalysis.

121 TET-family dioxygenases catalyze conversion of 5-methylcytosine (5m

122 Ten-eleven-translocation (TET) dioxygenases catalyze the oxidation of 5-methylcytosine

123 clic arene metabolite, obtained from toluene dioxygenase-catalyzed regioselective and stereoselective

124 and HPPD1, encoding 4-hydroxyphenylpyruvate dioxygenase catalyzing the committed step of plastoquino

125 ted by the efficiency of Carotenoid Cleavage Dioxygenases (CCD), membrane-tethered enzymes catalyzing

126 Carotenoid cleavage dioxygenases (CCDs) are non-heme iron-containing enzymes

127 Carotenoid cleavage dioxygenases (CCDs) use a nonheme Fe(II) cofactor to spl

128 ds through the action of carotenoid cleavage dioxygenases (CCDs).

129 mately tied to the function of both cysteine dioxygenases (CDOs) and nitrile hydratases (NHases), and

130 all structure is consistent with other thiol dioxygenases, closer inspection of the active site indic

131 transferase inhibitor), and vitamin C (a TET dioxygenase co-activator), that together produced comple

132 alphaKG-dependent dioxygenases consume the metabolite alphaKG (also known

133 hromosome-encoded three-component nitroarene dioxygenase (DcnAaAbAcAd) converted 3,4-DCNB stoichiomet

134 asmid-borne ring-cleavage chlorocatechol 1,2-dioxygenase (DcnC).

135 9 +/- 0.1 and 9.7 +/- 0.1) differs from both dioxygenase ( E(m,7) ~ -150 mV, p K(ox1,2) = 9.8 and 11.

136 the alpha-ketoglutarate (alphaKG)-dependent dioxygenase Egln1, which senses oxygen and regulates the

137 y biosynthetic alpha-ketoglutarate-dependent dioxygenase enzyme in a biotransformation methodology to

138 ide synthase enzymes as compared to cysteine dioxygenase enzymes and present pathways for both reacti

139 eviously showed that two CAROTENOID CLEAVAGE DIOXYGENASE enzymes, CCD1 and CCD4, are the primary medi

140 restricting the activity of prolyl hydroxyl dioxygenase enzymes, which hydroxylate HIF-1alpha and HI

141 Ten-eleven translocation (TET) enzyme family dioxygenases, excision of the latter oxidation products

142 en-eleven translocation (TET) methylcytosine dioxygenase expression and loss of the DNA hydroxymethyl

143 umulation of CD11c cells and indoleamine 2,3-dioxygenase expression.

144 ctor was highly correlated with naringenin 3-dioxygenase (F3H) and dihydroflavonol-4-reductase (DFR)

145 are members of the 2-oxoglutarate-dependent dioxygenase family and comprise three isoenzymes in huma

146 the Fe (II)- and oxoglutarate-dependent AlkB dioxygenase family and is linked to both obesity and int

147 n-2 (TET2) is a member of the methylcytosine dioxygenase family of enzymes and has been implicated in

148 mbers of the oxygen/2-oxoglutarate-dependent dioxygenase family, including the HIF proline hydroxylas

149 The plant non-heme iron dioxygenase flavonol synthase performs a regioselective

150 he function of the Arabidopsis thaliana gene DIOXYGENASE FOR AUXIN OXIDATION 1 (AtDAO1).

151 Here, we show that DIOXYGENASE FOR AUXIN OXIDATION 1 (DAO1) catalyzes forma

152 5-methylcytosine (5mC) by Tet methylcytosine dioxygenases, for which Fe(II) is an essential cofactor.

153 Finally, we identify a cluster of mono- and dioxygenase fourth-level enzyme classes that most strong

154 The prediction identified biphenyl dioxygenase from Paraburkholderia xenovorans LB400 as th

155 of a related enzyme, hydroxyethylphosphonate dioxygenase from Streptomyces albus (SaHEPD), and find t

156 dioxygenases, and transformed tryptophan 2,3-dioxygenase from Xanthomonas campestris into a monooxyge

157 7 genes [e.g., alpha-ketoglutarate dependent dioxygenase (FTO), interleukin 6 (IL6), insulin receptor

158 es O(2) and NO cooperatively activate the NO dioxygenase function of Escherichia coli flavohemoglobin

159 ochondrial 2-OG metabolism to 2-OG dependent dioxygenase function.

160 m genome sequence, we identified a quercetin dioxygenase gene (QDO) and characterized the encoded pro

161 PU demethylated products; a distinct aniline dioxygenase gene cluster adoQTA1A2BR, which has a broad

162 oxidations of 5-methylcytosine (5mC) by Tet dioxygenases generate 5-hydroxymethyl (5hmC), 5-formyl (

163 hC, encoding the meta-cleavage alkylcatechol dioxygenase, grew on guaiacol but not 4PG.

164 enine pathway, 3-hydroxyanthranilic acid 3,4-dioxygenase (HAAO) and kynureninase (KYNU).

165 nistic analysis of 2-hydroxyethylphosphonate dioxygenase (HEPD), which cleaves the C1-C2 bond of its

166 nherited disease caused by homogentisate 1,2-dioxygenase (HGD) deficiency.

167 GmHGO1 encodes a homogentisate dioxygenase (HGO), which catalyzes the committed enzymat

168 TET2, a methylcytosine dioxygenase highly expressed in these cells and frequent

169 chia coli expressing homoprotocatechuate 2,3-dioxygenase (HPCD) as a model biocatalyst and coated it

170 ological function of 4-hydroxyphenylpyruvate dioxygenase (HPPD), as well as on the development and ap

171 3-dioxygenase 1 (hIDO1) and human tryptophan dioxygenase (hTDO) are two important heme proteins that

172 ine 2,3-dioxygenase 1 (hIDO1) and tryptophan dioxygenase (hTDO) are two of the only three heme-based

173 Indoleamine 2,3 dioxygenase (IDO) and arginase 1 (ARG1), which cataboliz

174 hibitory molecules including indoleamine 2,3-dioxygenase (IDO) and programmed cell death ligand 1 (PD

175 ppression through the enzyme indoleamine 2,3-dioxygenase (IDO) and subsequent production of kynurenin

176 phan caused by expression of indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) r

177 Additionally, indoleamine 2,3-dioxygenase (IDO) expression was only modestly increased

178 Indoleamine 2,3-dioxygenase (IDO) has immunoregulatory roles associated

179 ugate of PEG with NLG919, an indoleamine 2,3-dioxygenase (IDO) inhibitor currently used for reversing

180 Indoleamine 2, 3-dioxygenase (IDO) is an immunoregulatory enzyme that bre

181 Indoleamine 2,3-dioxygenase (IDO) is the enzyme that catalyzes the degra

182 Indoleamine 2,3-dioxygenase (IDO) is the first and rate-limiting enzyme

183 ing in the immunosuppressive indoleamine 2,3-dioxygenase (IDO) pathway.

184 an 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO) play a central role in tryptophan meta

185 ophan (Trp) catabolic enzyme indoleamine 2,3-dioxygenase (IDO) represent a vanguard of new immunometa

186 stigated the relationship of indoleamine 2,3-dioxygenase (IDO) systemic activity on clinical outcomes

187 tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO) were analyzed using flow cytometry and

188 Inflammation activates indoleamine 2,3-dioxygenase (IDO) which metabolizes tryptophan into kynu

189 s expressed higher levels of indoleamine 2,3-dioxygenase (IDO), an enzyme associated with tolerance i

190 is induced the expression of indoleamine 2,3-dioxygenase (IDO), an enzyme involved in tryptophan cata

191 interferon-gamma (IFNgamma), indoleamine 2,3 dioxygenase (IDO), and human leukocyte antigen G (HLA-G)

192 pecific inhibitor of indoleamine-pyrrole 2,3-dioxygenase (IDO), but not by NSC-398, a specific inhibi

193 an 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO), during its conversion to N-formylkynu

194 otherapy agent that inhibits indoleamine 2,3-dioxygenase (IDO), encapsulated in the nMOF channels to

195 ing plasma concentrations of indoleamine 2,3-dioxygenase (IDO), KYN, kynurenic acid (KynA), and quino

196 Indoleamine 2,3-dioxygenase (IDO), the rate-limiting enzyme in the trypt

197 Indoleamine 2,3-dioxygenase (IDO), which degrades tryptophan (Trp) to ky

198 yptophan-metabolizing enzyme indoleamine 2,3-dioxygenase (IDO).

199 via induction of the enzyme indoleamine-2,3-dioxygenase (IDO).

200 yptophan catabolizing enzyme indoleamine-2,3-dioxygenase (IDO).

201 egulatory mechanisms such as indoleamine 2,3 dioxygenase (IDO).

202 an (Trp)-catabolizing enzyme indoleamine 2,3-dioxygenase (IDO).

203 n-depleting enzymes [i.e. the indolamine-2,3 dioxygenase (IDO)1 and IDO2) in the placenta.

204 catabolizing enzymes such as indoleamine 2,3-dioxygenase (IDO-1) to induce an immunosuppressive envir

205 h indoleamine 2,3-dioxygenase/tryptophan 2,3-dioxygenase (IDO/TDO) inhibitors.

206 Furthermore, while indoleamine 2,3-dioxygenase (IDO1) drives AhR activation in other settin

207 Indoleamine 2,3-dioxygenase (IDO1) inhibitors are speculated to be usefu

208 Indoleamine 2,3-dioxygenase (IDO1) is a heme enzyme that catalyzes the o

209 reated PDACs express minimal indoleamine-2,3-dioxygenase (IDO1); however, GVAX therapy induced IDO1 e

210 also present in LsdB, another lignostilbene dioxygenase in S. paucimobilis TMY1009, rationalizing Ls

211 (hTDO) are two of the only three heme-based dioxygenases in humans.

212 ctor for Fe(II) and 2-oxoglutarate-dependent dioxygenases including TET family enzymes, which catalyz

213 formylkynurenine is catalysed by a family of dioxygenases, including indoleamine 2,3-dioxygenase 1(5)

214 microbiota that could limit indoleamine 2,3-dioxygenase induction and influence allogeneic T cell re

215 conditions, a broad-spectrum 2-oxoglutarate dioxygenase inhibitor is a better mimic of the overall t

216 by modulating the activity of 2-OG dependent dioxygenases involved in the hypoxia response and DNA/hi

217 NsrR, and nod; the nod-encoded nitric oxide dioxygenase is important for preventing nitric oxide str

218 cause aromatic dioxygenation by nonheme iron dioxygenases is frequently the initial step of biodegrad

219 A subclass of molecular dioxygenases is the histone demethylase enzymes, which a

220 zymes known as alpha-ketoglutarate-dependent dioxygenases, leading to epigenetic dysregulation and in

221 and a novel C-terminal hydroxyphenylpyruvate dioxygenase-like domain.

222 s reveal a detailed stepwise O-atom transfer dioxygenase mechanism along with potential isomerization

223 The trends exclude multiple dioxygenase mechanisms as well as the proposal that init

224 the ten-eleven translocation (TET) family of dioxygenase-mediated DNA demethylation requires new meth

225 ersed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to 5-hydroxymethyl

226 a co-factor of Fe2(+) and alpha-KG-dependent dioxygenases, mimics TET2 restoration by enhancing 5-hyd

227 h is supplied by a dedicated indoleamine-2,3-dioxygenase NanC encoded in the gene cluster.

228 mes, namely, nitrobenzene and 2-nitrotoluene dioxygenase (NBDO and 2NTDO) to elucidate the enzyme- an

229 rotenoid precursors by 9-cis epoxycarotenoid dioxygenase (NCED) and inactivation of ABA by ABA 8'-hyd

230 ibit reactivity related to both nitric oxide dioxygenase (NOD) and nitrite reductase (NiR) activity.

231 diate in the catalytic cycle of nitric oxide dioxygenase (NOD) enzymes, which facilitate a .NO homeos

232 The identity of the specific nitric oxide dioxygenase (NOD) that serves as the main in vivo regula

233 r NO. detoxification systems are Hmp, an NO. dioxygenase (NOD), and NorV, an NO. reductase (NOR).

234 he oxygenation of unsaturated fatty acids by dioxygenases occurs in all kingdoms of life and produces

235 The ten-eleven translocation (TET) dioxygenases oxidize 5mC into oxidized methylcytosines (

236 tion of IL-10 (P < .047) and Indolamine-2, 3-dioxygenase (P = .050).

237 on of enzymes comprising the protocatechuate dioxygenases (PCADs) has been characterized in several e

238 :quinone oxidoreductase (SQR) and persulfide dioxygenase (PDO) genes.

239 s sulfide quinone oxidoreductase, persulfide dioxygenase (PDO), rhodanese, and sulfite oxidase and co

240 er animal cells deploy three closely related dioxygenases (PHD 1, 2 and 3) to signal oxygen levels by

241 gulated by prolyl-4-hydroxylase domain (PHD) dioxygenases PHD1, PHD2, and PHD3, which function as cel

242 Indoleamine 2,3-dioxygenase plays a key role in local tryptophan metabol

243 The TET family of 5-methylcytosine (5mC) dioxygenases plays critical roles in development by modi

244 o metal-bound enol tautomers of the unstable dioxygenase product.

245 ion of di-iron enzyme catalysis to include a dioxygenase reactivity in which an unactivated alkene is

246 , OdaA and OdaI have predicted hydratase and dioxygenase reductase activities, respectively.

247 mpact characterization of human ALKBH family dioxygenases related to prostate cancer.

248 of the protein and a catalytically inactive dioxygenase-related N-terminal domain, which is importan

249 KBH7) is a mitochondrial alpha-ketoglutarate dioxygenase required for DNA alkylation-induced necrosis

250 d by the Mettl4 methyltransferase and Alkbh4 dioxygenase, respectively, and that 6mA accumulation in

251 nonheme iron-based 3-hydroxyanthranilate-3,4-dioxygenase responsible for quinolinic acid production w

252 ion of 5mC by ten-eleven translocation (TET) dioxygenases results in a cascade of additional epigenet

253 o groups of LD-associated proteins, caleosin/dioxygenase/steroleosin and LD/oil body-associated prote

254 the host gene encoding 9-cis-epoxycarotenoid dioxygenase (TaNCED-5BS), which catalyzes the rate-limit

255 This work revealed the first tryptophan 2,3-dioxygenase (Tar13) and kynurenine formamidase (Tar16) e

256 esis is normally catalyzed by Tryptophan 2,3 Dioxygenase (TDO [18-20]).

257 of the Trp catabolic enzymes tryptophan 2,3-dioxygenase (TDO) and IDO2 may also safely broaden effic

258 Tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO)

259 mediated by two heme enzymes, tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO),

260 ine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) resulted in ATF4-dependent upregulatio

261 xpress high levels of AHR and tryptophan-2,3-dioxygenase (TDO); representative ER(-)/PR(-)/Her2(-) ce

262 Trp and Arg catabolism (IDO1, IDO2, Trp 2,3-dioxygenase [TDO], arginase [ARG] 1, ARG2, inducible NO

263 ted by ibuprofen was neuronal tryptophan 2,3-dioxygenase (Tdo2), which encodes an enzyme that metabol

264 icle, we demonstrate that the methylcytosine dioxygenase ten-eleven translocation (TET)2 regulates CD

265 DNA methylcytosine dioxygenase Ten-eleven translocation 1 (TET1) is a criti

266 opioids were not observed in methylcytosine dioxygenase ten-eleven translocation 1 (Tet1) knockout N

267 in metastatic tumours in the methylcytosine dioxygenase ten-eleven translocation 2 (TET2), which is

268 Here we examined a possible role for the DNA dioxygenase, ten-eleven translocation protein 1 (TET1),

269 s (stage I) followed by a Tet methylcytosine dioxygenase (Tet)-dependent decrease in methylated cytos

270 In contrast, methylcytosine dioxygenase TET1 (TET1) expression was substantially red

271 Here, we reveal the methylcytosine dioxygenases TET1 and TET2 as active regulators of CTCF-

272 s of ten-eleven translocation methylcytosine dioxygenase (TET2)-mediated 5-hydroxymethylcytosine (5-h

273 a sophisticated evolution of the nitroarene dioxygenase that avoids misrouting of toxic intermediate

274 TET2 is a dioxygenase that catalyses multiple steps of 5-methylcyt

275 duct, ArsI, is an Fe(II)-dependent extradiol dioxygenase that cleaves the carbon-arsenic (C-As) bond

276 lpha-ketoglutarate-dependent non-heme Fe(II) dioxygenase that forged the azetidine ring on the okaram

277 anslocation-2 (Tet2) is a DNA methylcytosine dioxygenase that functions as a tumor suppressor in hema

278 rohydroquinone, demonstrating that ArsI is a dioxygenase that incorporates one oxygen atom from dioxy

279 TET3 is a methylcytosine dioxygenase that initiates DNA demethylation during earl

280 cterial Fe(II)- and 2-oxoglutarate-dependent dioxygenase that repairs a wide range of alkylated nucle

281 ity (high-K (m)O(2)) amino-terminal cysteine dioxygenase that transduces the oxygen-regulated stabili

282 I is a microbial non-heme, ferrous-dependent dioxygenase that transforms toxic methylarsenite [MAs(II

283 Cells possess enzymes called molecular dioxygenases that depend on oxygen for activity.

284 nal is generated by 2-oxoglutarate-dependent dioxygenases that deploy molecular oxygen as a co-substr

285 ally redundant alpha-ketoglutarate-dependent dioxygenases that generate a cryptic C7 beta-hydroxyl on

286 alpha-ketoglutarate- and iron(II)-dependent dioxygenases that hydroxylate four sp(3) carbons; one fl

287 are alpha-ketoglutarate (alpha-KG)-dependent dioxygenases that oxidize 5-methylcytosine (5mC) to 5-hy

288 urn stimulates alpha-ketoglutarate-dependent dioxygenases that remove the repressive histone modifica

289 ing that in the absence of homogentisate 1,2-dioxygenase the intermediary in tyrosine catabolism homo

290 combining PD1 blockade with indoleamine 2,3-dioxygenase/tryptophan 2,3-dioxygenase (IDO/TDO) inhibit

291 in part by reducing the function of Tet2, a dioxygenase tumour suppressor.

292 Previously, we have shown that cysteine dioxygenase type 1 (Cdo1) promoted adipogenesis of prima

293 ater expression of 3-hydroxyanthranilate 3,4-dioxygenase was identified as a potential contributor to

294 ture structure of an extradiol ring-cleaving dioxygenase was solved by utilizing the improved operati

295 luorescens ATCC 17483 containing naphthalene dioxygenases was associated with moderate carbon isotope

296 tion, expression of IL-2 and indoleamine 2,3-dioxygenase were evident in TLR4 compared with WT allogr

297 tB shows structural similarities to cysteine dioxygenase which transfers two oxygen atoms to the thio

298 mediated by the host enzyme indoleamine 2,3-dioxygenase, which converts l-tryptophan to N-formylkynu

299 ne], an inhibitor of 4-hydroxyphenylpyruvate dioxygenase, which is upstream of FAH.

300 y of alpha-ketoglutarate (alphaKG)-dependent dioxygenases, which include several chromatin-modifying