ライフサイエンスコーパス: dipeptide

1 and nonbiased exit of one of the products (a dipeptide).

2 he three distinct oxygen environments of the dipeptide.

3 ate interatomic distances in a fully labeled dipeptide.

4 h polymerization and binding by the PRn poly-dipeptide.

5 of the free energy landscape of the alanine dipeptide.

6 ately the same distance apart as in a normal dipeptide.

7 -permeable and free in solution, to form the dipeptide.

8 g in response to the bacterial motif muramyl dipeptide.

9 s FemA and FemB sequentially add two Gly-Gly dipeptides.

10 lating ion-coupled absorption of glucose and dipeptides.

11 adily switched from 0% to 100% in Xaa-PsiPro dipeptides.

12 f the six divalent ions with amino acids and dipeptides.

13 across the entire series of amino acids and dipeptides.

14 tive to this puromycin analogue to recognize dipeptides.

15 zed by two highly conserved tyrosine-leucine dipeptides.

16 urable structures for C-domain inhibition in dipeptides.

17 sion of the C9BAC transgene and the poly(GP) dipeptides.

18 nd oil as well as to analyze amino acids and dipeptides.

19 ways and with lower levels of gamma-glutamyl dipeptides.

20 blend, or a combined blend with both cyclic dipeptides.

21 aving modified ribosomes able to incorporate dipeptides.

22 p (n = 75) received PN containing alanyl-GLN dipeptide (0.5 g/kg/d), proportionally replacing AA in P

23 Single-crystal XRD analysis of the dipeptide 1 showed parallel beta-sheet arrangement along

24 The crystals of dipeptide 1, upon heating at 85 degrees C, underwent cry

25 A protein containing both thiolated dipeptide 4 and a 7-methoxycoumarin fluorophore was foun

26 han-, tyrosine- and phenylalanine-containing dipeptides, 50-80% of the total ACE-inhibiting potential

27 Carnosine is a dipeptide abundantly found in human skeletal muscle, car

28 , and lead to both repeat-containing RNA and dipeptide accumulation, coupled with decreased C9orf72 p

29 pH-switching properties of the new family of dipeptide-acetylene conjugates where pH-gated light-acti

30 lpP1P2 complex requires binding of N-blocked dipeptide activators.

31 rks of hepatotoxicity such as gamma-glutamyl dipeptides, acylcarnitines, and proline derivatives.

32 Dipeptides adopt one of two intramolecular-hydrogen bond

33 In the solid state, the dipeptide adopted a fully extended conformation featurin

34 eld for lauroyl glycine and less than 5% for dipeptide after 96h of synthesis, at 45 degrees C and ac

35 taste papillae (HBO) cells with five arginyl dipeptides: Ala-Arg (AR), Arg-Ala (RA), Arg-Pro (RP), Ar

36 (2) and Phe-Gly (3)), as well as a thiolated dipeptide analogue (4) and a fluorescent oxazole (5) hav

37 cal properties when compared to a library of dipeptide analogues, thus validating the uniqueness of t

38 of NEDD8 protein, without the use of special dipeptide analogues.

39 ng and that interaction between the PRn poly-dipeptide and LC domains is polymer-dependent.

40 st, a homologue from Escherichia coli, DtpA (dipeptide and tripeptide permease), shows a high similar

41 poration of d-amino acids, beta-amino acids, dipeptides and dipeptidomimetic analogues of the normal

42 mycin analogue, were employed to incorporate dipeptides and dipeptidomimetics.

43 in the range of 0-200muM for the individual dipeptides and in the range of 0-100muM for each dipepti

44 e report the individualization of four polar dipeptides and of four nonpolar phosphorus-containing co

45 cis lethal toxin, Toxoplasma gondii, muramyl dipeptide, and host intracellular ATP depletion.

46 energy trends for twenty amino acids, their dipeptides, and their interactions with the divalent cat

47 ne adopts cis-conformation in simple amides, dipeptides, and tripeptides whereas its carbamate-protec

48 tathione disulfide) and histidine-containing dipeptides (anserine) within muscle tissue that was dist

49 s of prodrugs in comparison to CLsuGG; (iii) dipeptides apparently increase the efficacy of the prodr

50 Hence, tryptophan containing dipeptides are interesting ingredients for functional fo

51 of neurotoxicity associated with these poly-dipeptides are not clear.

52 These results suggest that the N-chlorinated dipeptides are produced by chlorination.

53 Dipeptides are widely present in surface water and serve

54 demonstrate the feasibility of incorporating dipeptides as a single ribosomal event, and illustrate t

55 e report the identification of N-chlorinated dipeptides as chlorination products in drinking water us

56 This study has identified N-chlorinated dipeptides as new disinfection byproducts in drinking wa

57 This loop further contains an (872)GG(873) dipeptide, as well as two aromatic residues ((871)W and

58 (RE), and Glu-Arg (ER); and two non-arginyl dipeptides: Asp-Asp (DD) and Glu-Asp (ED).

59 pha-chymotrypsin and driven by hydrolysis of dipeptide aspartyl-phenylalanine-methyl ester (the sweet

60 e to tune the aspect ratio of populations of dipeptide assemblies.

61 natural and unnatural amino acids and three dipeptides at position 6 that emerged as potent mu/delta

62 es and leave the signature C-terminal GlyGly dipeptide attached to the modified residue; this simplif

63 icate that carnosine, a histidine containing dipeptide available through the diet, is an effective sc

64 tro screens identified MTM(ox)32E (a Phe-Trp dipeptide-based 2'-conjugate) for in vivo testing.

65 of an additional activating factor (e.g. the dipeptide benzyloxycarbonyl-leucyl-leucine in vitro) to

66 e spatial conformation of the minimal pseudo-dipeptide binding motif of pepstatin A, a microbial olig

67 The PRn poly-dipeptide binds to polymeric forms of the phenylalanine:

68 Ala to the medium inactivated DdlR, reducing dipeptide biosynthesis.

69 vities that cleave the proline-phenylalanine dipeptide bond in Ang II.

70 ted WT mice received the NOD2 ligand muramyl dipeptide, both hyperglycemia and the proinflammatory im

71 -A*02:01, together with structures that have dipeptides bound in the A and F pockets.

72 The use of a pseudoproline dipeptide building block was found to be important for o

73 he model [2]-catenane is self-assembled from dipeptide building blocks and contains an extensive netw

74 s that expression of the arginine-containing dipeptides, but not alanine-containing dipeptides, produ

75 use it is the rate-limiting precursor of the dipeptide carnosine (beta-alanyl-l-histidine) in muscle.

76 ntitate two biologically important histidine dipeptides, carnosine and anserine, using capacitively c

77 ed in vitro data, revealing that each of the dipeptides caused toxicity, with poly GA being the most

78 Unique dipeptide-coding uORFs and nucleotide motifs, such as '5

79 can are mediated by detection of its muramyl dipeptide component in the cytosol by NOD2, we report he

80 Three steps are included: (i) the g-gap dipeptide composition (g-gap DC), pseudo-amino acid comp

81 g a formamidinylated, N-hydroxylated Gly-Gln dipeptide conjugated to 6'-amino-pseudouridine.

82 Dipeptide conjugates with coprostanol and estradiol were

83 C-terminus with a variety of cysteine-lysine dipeptide conjugates.

84 Here we describe a simple and robust FLFL-dipeptide construct to which a meso-tetraphenylporphyrin

85 A designed beta-sheet-forming l-Ala-l-Val dipeptide containing azide and alkyne at its termini (N3

86 Interestingly, external supply of dipeptides containing BCAAs and ARO AAs rescues cell pro

87 Additionally, comparison of adhesion of dipeptides containing Lys and either DOPA (KY) or phenyl

88 PNTs have been made from Fmoc dipeptides, cyclic peptides, and lock-washer helical bun

89 Here, we identified two volatile cyclic dipeptides, cyclo(L-Leu-L-Pro) and cyclo(L-Pro-L-Pro), f

90 The tricyclic acetonide of the dipeptide d-Hot horizontal lineTap is resistant to TFA a

91 genes, is responsible for the synthesis of a dipeptide, D-Ala-D-Ala, an essential precursor of bacter

92 e discovery of the self-immolative l-Phe-Sar dipeptide derivative 74 that gave four-fold improved AUC

93 us works demonstrated that PriSM formed by a dipeptide derivative selectively inhibiting the growth o

94 a-diamino esters to afford the corresponding dipeptide derivatives in good yields.

95 formed under PTC to obtain C60-amino acid or dipeptide derivatives in yields up to 80% by P-C bond fo

96 We have prepared water-soluble phosphate and dipeptide derivatives of the KATP channel opener cromaka

97 hen the o-boronato-phosphonium amino acid or dipeptide derivatives were mixed with fluoride, the corr

98 Although acting preferentially on basic dipeptides derived from beta-alanine or gamma-aminobutyr

99 es (CAPs), demonstrating that valine-glycine dipeptide-derived CAP 3 is the most effective antimicrob

100 structures of isolated amino acids and their dipeptides emerge as lowest-energy conformers.

101 The toxic proline:arginine (PRn) poly-dipeptide encoded by the (GGGGCC)n repeat expansion in t

102 e intracellular targets of the toxic PR poly-dipeptide encoded by the repeat sequences expanded in th

103 ependent formation of the d-alanyl-d-alanine dipeptide essential for bacterial cell wall biosynthesis

104 unsymmetrical urea A and carboxy-imidazolyl-dipeptide ester B intermediates.

105 y acids (n3 and n6), eicosanoids, lysolipid, dipeptides, fatty acid metabolism, and purine metabolism

106 The model dipeptide Fmoc-Tyr(All)-Tyr(All) was used to explore dif

107 Herein, a minimalistic, de novo dipeptide, Fmoc-Lys(Fmoc)-Asp, as an hydrogelator with t

108 This dipeptide forms the central motif of the Abeta peptides,

109 The second module consisted primarily of dipeptides ([Formula: see text], e.g., isoleucylglycine)

110 this engineered enzyme in the synthesis of a dipeptide fragment of the antibiotic enduracidin.

111 Reductive cleavage of an L-Pro-L-Trp dipeptide from the MalG non-ribosomal peptide synthetase

112 The aminopeptidase DPP9 removes dipeptides from N-termini of substrates having a proline

113 of function, toxicity by the expanded RNA or dipeptides from non-ATG-initiated translation are respon

114 we investigated the formation of halogenated dipeptides from three aromatic dipeptides, phenylalanylg

115 Extraction of six dipeptides from water using these new SiMNS-SO(3)Na SPE

116 12-iE-DAP (acylated derivative of the iE-DAP dipeptide [gamma-d-glutamyl-meso-diaminopimelic acid]) a

117 iomeric excess of mixed monolayers of chiral dipeptides gave rise to continuous changes in the orient

118 We synthesized a dipeptide gelator decorated with azide and alkyne at its

119 complex with the peptide exchange-associated dipeptide GL, as well as the tapasin-associated scoop lo

120 tuted and N-unsubstituted alpha-amino acids, dipeptide Gly-Gly, and also benzylamine were used as the

121 The four incorporated species included two dipeptides (Gly-Phe (2) and Phe-Gly (3)), as well as a t

122 ity towards the lipoaminoacid instead of the dipeptide glycylglycine and synthesis yield were evaluat

123 -tetrahydropyranyl-4-carboxylic acid derived dipeptide GSK-2793660, which is currently in clinical tr

124 ization of a tetrahydro-beta-carboline-based dipeptide has been developed to prepare new indole-fused

125 d for the preparation of triazole-containing dipeptides having the structural motives typical of turn

126 f carnosine and related histidine-containing dipeptides (HCDs) is not clear.

127 rationally designed and the lead, phosphinic dipeptide hPhePpsi[CH2]Phe, was modified in a single pos

128 to pronase treatment yielding the alkylated dipeptide hydroxyethylthioethyl-CysPro (HETE-CP) derived

129 C activates ProT by inserting its N-terminal dipeptide Ile(1)-Val(2) into the ProT Ile(16) pocket, fo

130 Third, an Arg-Asp dipeptide immediately preceding the ZF helix, conserved

131 Val amino acid and Val-Val dipeptides imparted low plasma exposure of the parent, a

132 ural explanation for the role of the His-Gly dipeptide in the structure and function of ASICs.

133 cy and efficiency on the examples of alanine dipeptide in vacuum and C-terminal beta-hairpin of prote

134 To determine halogenated dipeptides in authentic water samples, we developed a ne

135 enable sensitive detection of N-chlorinated dipeptides in authentic water, we developed a high-perfo

136 nd widespread production of RNA foci and RAN dipeptides in C9-BACexp mice, behavioral abnormalities a

137 of Br- and mixed halogen (Cl, Br, and/or I)-dipeptides in disinfected water have not been studied.

138 The limit of detections (LOD) for the dipeptides in the mixture were 0.10muM for carnosine and

139 e identified after chloramination of tyrosyl dipeptides in the presence of I(-) and were detected in

140 ange of 2 to 11, and efficient enrichment of dipeptides in water.

141 ormed from helical to coccoid, peptidoglycan dipeptides increased and tri- and tetrapeptides decrease

142 ir with FemA and FemB to incorporate Gly-Ser dipeptides into cross-bridges and to confer resistance t

143 e were shown to support the incorporation of dipeptides into proteins.

144 Formation of the dipeptide is followed by C3'-epimerization to produce SB

145 de proves a modular binding mode, where each dipeptide is recognized by one internal repeat.

146 rofuran (bis-THF) in a pseudo-C(2)-symmetric dipeptide isostere are described.

147 -1 PIs containing bis-THF in non-sulfonamide dipeptide isosteres.

148 structure-activity relationships (SAR) of a dipeptide library bearing Arg alpha-ketobenozothiazole (

149 2 also acted at lower rates on some "classic dipeptides" like alpha-alanyl-lysine and alpha-lysyl-lys

150 Cys34 of albumin via a cathepsin B-sensitive dipeptide linker to ensure that all drug would be bound

151 s using lysosome-cleavable valine-citrulline dipeptide linkers via heterogeneous lysine conjugation a

152 The serine-glycine dipeptide lipid classes, including lipid 430 and lipid 6

153 e structurally related to the serine-glycine dipeptide lipids.

154 ly to the previously reported serine-glycine dipeptide lipids.

155 on by human monocytes activated with muramyl dipeptide (MDP) adjuvant, which activates cytosolic nucl

156 induced TNF-alpha can be affected by muramyl dipeptide (MDP) in a biphasic concentration-dependent ma

157 Here we investigated the effects of muramyl dipeptide (MDP), a bacterial cell wall component that ac

158 ycobacterial cell wall component and muramyl dipeptide (MDP), a peptidoglycan derivative respectively

159 -containing protein 2 (NOD2) agonist muramyl dipeptide (MDP), a peptidoglycan motif common to all bac

160 decades ago, it was identified that muramyl dipeptide (MDP), a peptidoglycan-derived bacterial cell

161 nts, such as the NOD2 cognate ligand muramyl dipeptide (MDP), and are selectively required for NOD2 r

162 h receptor, NOD2, via recognition of muramyl dipeptide (MDP), triggers a distinct network of innate i

163 in response to i.p. and intravitreal muramyl dipeptide (MDP).

164 phosphorylation of IRF5 by microbial muramyl-dipeptides (MDP), the minimal structural motif of peptid

165 R132H) expression increased the abundance of dipeptide metabolites, depleted key tricarboxylic acid c

166 ns models of ALS, suggesting that the (PR)50 dipeptide might engage similar toxicity mechanisms as ot

167 rminally blocked delta-amino acid residue, a dipeptide mimic, by replacing its central amide moiety w

168 Here, we employed a dipeptide model of oxidized PTP1B to investigate the nuc

169 DppA (dipeptide), MppA (murein tripeptide), and SapA (antimicr

170 reveal that the pathways altered by the poly-dipeptides-mRNA complexes are potential therapeutic targ

171 bserved in the reactions of CumO(*) with the dipeptides N-BocProGlyOH and N-BocGlyGlyOH.

172 ids, FMOC-l-leucine and FMOC-l-valine, and a dipeptide, N-acetyl-l-valyl-l-leucine (N-Ac-VL), were st

173 ow the formation of tryptophan-phenylalanine dipeptide nanoparticles (DNPs) that can shift the peptid

174 o polycrystalline specimens of two different dipeptide nanotubes: l-Ala-l-Val and its retro-analog l-

175 issue damage, whereas treatment with muramyl dipeptide (NOD2 ligand), which increases PMo mass, reduc

176 porting the hypothesis that RNA foci and RAN dipeptides occur presymptomatically and are not sufficie

177 cement of the C-terminal Leu(13)-Met(14)-NH2 dipeptide of SB3 by Sta(13)-Leu(14)-NH2, the novel GRPR

178 ceptor, sialic acid, by supplying a critical dipeptide on their projecting, heavy-chain third complem

179 All strains accumulated peptidoglycan dipeptides over time, but only strains capable of becomi

180 mycin derivative in this study contained the dipeptide p-methoxyphenylalanylglycine, implying the abi

181 The l-serine-thioheptose dipeptide partial structure, known as SB-217452, has bee

182 ntly with the appearance of pentapeptide and dipeptide peptidoglycan fragments and higher-molecular-w

183 to digest a small, synthetic tetrasaccharide dipeptide PG fragment into the cognate 1,6-anhydromuramy

184 f halogenated dipeptides from three aromatic dipeptides, phenylalanylglycine (Phe-Gly), tyrosylalanin

185 isting of lipids, and a second that included dipeptides, polyunsaturated fatty acids, taurine, and xa

186 cognition of the central peptide bond in the dipeptide, potentially enabling the incorporation of a b

187 n of the diene system, we easily converted a dipeptide precursor into the desired C6-functionalized a

188 ow that MYH15 could modulate the toxicity of dipeptides produced from expanded G4C2 repeat.

189 Tyrosyl dipeptides produced N-Cl-, 3-I-/3,5-di-I-, and N-Cl-3-I-

190 ining dipeptides, but not alanine-containing dipeptides, produces toxic phenotypes in multiple cellul

191 Depletion of PAF1C reduces RNA and GR dipeptide production from (G4C2)(30+) transgenes.

192 ructures of N-domain ACE in complex with the dipeptide products of Ac-SDKP cleavage were obtained and

193 rting that either C9orf72 transcripts or RAN dipeptides promote nucleolar dysfunction.

194 f this repeat gives rise to several distinct dipeptide protein species that could play pathological r

195 non-canonical translation into neural-toxic dipeptide proteins(3,4).

196 uniformly (13)C,(15)N and 70% (17)O-labeled dipeptide prove the attainability of (17)O as a probe fo

197 ded transcripts, as well as their translated dipeptide repeat (DPR) products, and also mitigated dege

198 Ectopic expression of the dipeptide repeat (DPR) protein (GR)80 in iPSC-derived co

199 Dipeptide repeat (DPR) proteins are toxic in various mod

200 ic mechanism is the aberrant accumulation of dipeptide repeat (DPR) proteins produced by the unconven

201 -ATG-dependent translation, generating toxic dipeptide repeat (DPR) proteins thought to contribute to

202 n in neuronal tissues and RAN translation of dipeptide repeat (DPR) proteins, as observed in patients

203 he characteristic pathological finding is of dipeptide repeat (DPR) proteins, formed by unconventiona

204 CAT-tailing-like modification of poly(GR), a dipeptide repeat derived from amyotrophic lateral sclero

205 in cellular and Drosophila models of C9orf72 dipeptide repeat neurotoxicity.

206 At autopsy, widespread RNA foci and dipeptide repeat protein inclusions were observed, but T

207 urgical resection tissue contained RNA foci, dipeptide repeat protein inclusions, and loss of nuclear

208 to express poly(PR), a proline-arginine (PR) dipeptide repeat protein synthesized from expanded G(4)C

209 ion of G4C2 RNA can result in five different dipeptide repeat proteins (DPR: poly GA, poly GP, poly G

210 Dipeptide repeat proteins (DPRs) produced by unconventio

211 expansion is translated into five different dipeptide repeat proteins (DPRs) that accumulate within

212 tional translation of these repeats produces dipeptide repeat proteins (DPRs) that may cause neurodeg

213 D) and lead to the production of aggregating dipeptide repeat proteins (DPRs) via repeat associated n

214 This mutation can produce five dipeptide repeat proteins (DPRs), of which three are kno

215 these expansions are translated to form five dipeptide repeat proteins (DRPs).

216 ipitate with the C9orf72 arginine-containing dipeptide repeat proteins (R-DPRs), poly-glycine arginin

217 ic forms of FTD, measures of progranulin and dipeptide repeat proteins in biofluids have become impor

218 epeats and the levels of repeat RNA foci and dipeptide repeat proteins in cortical neurons derived fr

219 r pathogenic molecules in C9ORF72-ALS/FTD is dipeptide repeat proteins such as poly(GR), whose toxici

220 AN translation) of C9orf72 repeats generates dipeptide repeat proteins that can cause neurodegenerati

221 Expression of repeat transcripts and dipeptide repeat proteins trigger multiple mechanisms of

222 y(Gly-Pro), poly(Gly-Ala), and poly(Gly-Arg) dipeptide repeat proteins, as well as TDP-43 pathology.

223 through the production of toxic aggregating dipeptide repeat proteins.

224 ranuclear RNA foci and poly(glycine-proline) dipeptide repeat proteins.

225 mutant Cu/Zn superoxide dismutase or C9orf72 dipeptide repeat proteins.

226 reactivating the NMD pathway could suppress dipeptide repeat toxicity.

227 sense- and antisense-expansion RNAs and six dipeptide repeat-associated, non-ATG (RAN) proteins, but

228 o ameliorated the degenerative phenotypes in dipeptide repeat-expressing flies, indicating that genet

229 ed to the unconventional translation of five dipeptide-repeat polypeptides (DPRs).

230 and frontotemporal dementia characterized by dipeptide-repeat protein (DPR) inclusions.

231 gical C9ORF72 transcripts, the production of dipeptide-repeat proteins and alleviates neurotoxicity i

232 ), in which the accumulation of RNA foci and dipeptide-repeat proteins are expected to modify RNA met

233 n loss, glial activation and accumulation of dipeptide-repeat proteins from translation of repeat-con

234 level-dependent accumulation of RNA foci and dipeptide-repeat proteins synthesized by AUG-independent

235 roduced sustained reductions in RNA foci and dipeptide-repeat proteins, and ameliorated behavioral de

236 n addition to possible RNA toxicity, several dipeptide repeats (DPRs) are translated through repeat-a

237 Moreover, arginine-rich dipeptide repeats (DPRs) derived from C9orf72 hexanucleo

238 cells expressing either of two arginine-rich dipeptide repeats (R-DPRs), poly(GR) and poly(PR).

239 Arginine-glutamic acid dipeptide repeats (RERE) is located in the proximal 1p36

240 ular mechanism whereby arginine-rich C9orf72 dipeptide repeats could inhibit NMD activities by reduci

241 eport the inhibition of NMD by arginine-rich dipeptide repeats derived from C9orf72 hexanucleotide re

242 locked neurotoxicity caused by arginine-rich dipeptide repeats in both cellular and Drosophila models

243 diated expression of C9orf72-related RNA and dipeptide repeats in the mouse central nervous system in

244 While RNA and dipeptide repeats produced by C9-HRE disrupt nucleocytop

245 mposed exclusively of arginine-aspartic acid dipeptide repeats undergo length-dependent condensation

246 NMD substrates and identified arginine-rich dipeptide repeats, including poly glycine-arginine and p

247 and side chain functions of the central turn dipeptide residue has demonstrated the sensitive relatio

248 e data suggest that toxicity of the PRn poly-dipeptide results in part from its ability to lock the F

249 he pentapeptide and 56%, 57% and 45% for the dipeptide, riboflavin and tryptophan respectively, howev

250 o identify and quantify for the first time a dipeptide S-conjugate to 3MH, the gammaGluCys-3MH, in Sa

251 pendent inhibitors of cruzain, composed of a dipeptide scaffold appended to vinyl heterocycles meant

252 The dipeptide self-assembles through an unusual and unpreced

253 Once internalized, these dipeptide species activate amino-acid signalling via a p

254 Our results demonstrate that dipeptide species support CML stem cell maintenance by a

255 ulate significantly higher levels of certain dipeptide species than normal HSCs.

256 s and tailored affinities by the assembly of dipeptide-specific modules based on armadillo repeats.

257 RF4 under either 55 unstimulated and muramyl dipeptide-stimulated conditions.

258 In vivo, the new 6-amino acid- and 6-dipeptide-substituted derivatives of 1 were highly effec

259 or the first time that tryptophan-containing dipeptides such as Ile-Trp or Val-Trp, which were recent

260 These include small cyclic dipeptides such as the insect feeding deterrent peramine

261 itored fish metabolites include amino acids, dipeptides, sugars, vitamins, biogenic amines, as well a

262 ocols for the preparation of various Xaa-Gly dipeptide surrogates in the form of Xaa-psi[triazole]-F2

263 An example of catalytic dipeptide synthesis is reported.

264 eses, and molecular architectonics of cyclic dipeptide tethered naphthalimides (CDP-NIs) to evaluate

265 ction, we designed an unnatural d-amino acid dipeptide that is metabolically incorporated into Lipid

266 To this end, we have investigated dipeptides that bind to the F pocket of class I molecule

267 mice, SLIT2 attenuates the uptake of muramyl dipeptide, thereby preventing NOD2-dependent activation

268 alent interactions with successive substrate dipeptides through two distinct classes of side chain bi

269 ily prepared by submitting the same starting dipeptide to a direct ring-closing enyne metathesis or a

270 ective cyclization of the tethered Ant-l-Kyn dipeptide to form the unusual benzazepine scaffold in 1.

271 Here, inspired by the ability of aromatic dipeptides to form ordered nanostructures with unique ph

272 ituted Val285 with Ala (V285A) in an Ala-Val dipeptide, to mimic the conserved Ala-Ala in many member

273 ers a mechanistic interpretation of PRn poly-dipeptide toxicity in the context of a prominent form of

274 ds to the accumulation of five types of poly-dipeptides translated from the GGGGCC hexanucleotide rep

275 port ATP-binding protein (NikE), periplasmic dipeptide transport protein (DppA), and outer membrane p

276 developed for the cleanup and enrichment of dipeptides, tripeptides, and tetrapeptides in urine usin

277 We present results for capped tyrosine dipeptide, two maquette systems containing one pH- and r

278 l identification and quantification of three dipeptides, Tyr-Gly, Phe-Gly, and Tyr-Ala, from raw wate

279 First, three model dipeptides, tyrosylglycine (Tyr-Gly), tyrosylalanine (Ty

280 c lateral sclerosis (ALS)-associated C9ORF72 dipeptides uncovered attenuated DEP recruitment during S

281 by the presence of a repeating alpha,epsilon-dipeptide unit have been prepared and characterized by (

282 tides such that each repeat interacts with a dipeptide unit within the stretched target peptide.

283 eins containing the catabody-sensitive Abeta dipeptide unit.

284 Importantly, pharmacological inhibition of dipeptide uptake inhibits CML stem cell activity in vivo

285 red by mechanochemistry from amino esters or dipeptides, via a 1,1'-carbonyldiimidazole-mediated one-

286 PN supplemented with GLN dipeptide was safe, but did not alter clinical outcomes

287 cted in the raw water, but the N-chlorinated dipeptides were at background levels.

288 The dipeptides were clearly detected in the raw water, but t

289 di-Cl-Tyr-Ala along with their corresponding dipeptides were detected in authentic tap water samples.

290 Recently Cl-, I-, and Cl-I-dipeptides were identified after chloramination of tyros

291 as well as N-Br- N-Cl- and N-Br-3-I-tyrosyl dipeptides were identified using infusion electrospray q

292 d solid phase extraction (C18 matrix), three dipeptides were identified.

293 and (GR)50-green fluorescent protein tagged dipeptides were present in the nucleus and nuclear local

294 These identified N-chlorinated dipeptides were synthesized and found to be stable in wa

295 ptides and in the range of 0-100muM for each dipeptide when both were present as a mixture.

296 d repeat-associated non-ATG (RAN) translated dipeptides, which were suppressed by antisense oligonucl

297 N-Cl-, 3-I-/3,5-di-I-, and N-Cl-3-I-tyrosyl dipeptides, while Phe-Gly formed only N-Cl-/ N, N-di-Cl-

298 that this transformation could be applied to dipeptides without racemization.

299 f tyrosine-containing peptides, ranging from dipeptides (YG, pYG, and sYG) over tripeptides (GYR, GpY

300 affold, while spontaneous cyclization of the dipeptide yielded the alternative kinetically favored be