ライフサイエンスコーパス: diphosphate

1 egometry in response to 20 mumol/L adenosine diphosphate.

2 nd reported to act on the 15-carbon farnesyl diphosphate.

3 ex with a pair of products TPP and adenosine diphosphate.

4 d, ThDP is modified to thiamine 2-thiazolone diphosphate.

5 on interacts with HMBPP, specifically at the diphosphate.

6 tro to the active antiviral metabolite, PMEG diphosphate.

7 cis and trans C(10) , C(15) and C(20) prenyl diphosphates.

8 he addition of prenyl transferases, farnesyl diphosphates, (2E,6E)-FDP and (2Z,6Z)-FDP, were isolated

9 scuss newly elucidated roles of guanosine 5'-diphosphate 3'-diphosphate (ppGpp) in transcription elon

10 ily oral PrEP (emtricitabine 200mg/tenofovir diphosphate 300mg) among pregnant and postpartum adolesc

11 ists (collagen-related peptide, adenosine 5'-diphosphate, A23187, thrombin, or U46619).

12 However, both reactions employ diphosphate-activated donors and each proceed via cation

13 Selected compounds tested at the two uridine diphosphate-activated P2Y receptor subtypes showed high

14 Nucleotide (ATP, adenosine diphosphate, adenosine monophosphate) and nucleoside (ad

15 hosphate (ATP) and its precursors, adenosine diphosphate (ADP) and adenosine monophosphate (AMP), usi

16 Adenosine diphosphate (ADP) enhances platelet activation by virtua

17 f the adenosine triphosphate (ATP)/adenosine diphosphate (ADP) exchange rates of F(1)-ATPase.

18 e the adenosine triphosphate (ATP)/adenosine diphosphate (ADP) metabolite ratio which strongly correl

19 adenosine monophosphate (AMP) and adenosine diphosphate (ADP) on flagellar beating is not fully unde

20 ing in one beta subunit and the adenosine 5'-diphosphate (ADP) release from another beta subunit occu

21 ures in the presence or absence of adenosine diphosphate (ADP) suggest that motions of the catalytic

22 by the release of extracellular adenosine 5'-diphosphate (ADP) that activated P2Y1 purinergic recepto

23 P) and its first five catabolites: adenosine diphosphate (ADP), adenosine monophosphate (AMP), inosin

24 ding adenosine triphosphate (ATP), adenosine diphosphate (ADP), and adenosine monophosphate (AMP); an

25 ensembles for p47-p97 complexes in adenosine diphosphate (ADP)- and adenosine triphosphate (ATP)-boun

26 icroscopy (cryo-EM) structures for adenosine diphosphate (ADP)-bound, full-length, hexameric wild-typ

27 The "young/strong" state 1 has adenosine 5'-diphosphate (ADP)-P (i) bound to Arp2/3 complex.

28 Protein adenosine diphosphate (ADP)-ribosylation is a physiologically and

29 ion elongation factor 2 (eEF2) via adenosine diphosphate (ADP)-ribosylation of a modified histidine r

30 naling (e.g., by sirtuins and poly-adenosine diphosphate [ADP] ribose polymerases [PARPs]) consumes c

31 Niraparib, an inhibitor of poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP), has been as

32 tors (adenosine triphosphate [ATP]/adenosine diphosphate [ADP]/adenosine monophosphate [AMP], nicotin

33 This reaction is catalyzed by the cytidine diphosphate-alcohol phosphotransferase phosphatidylinosi

34 the galactan is constructed from uridine 5'-diphosphate-alpha-d-galactofuranose (UDP-Galf), which is

35 phosphate-containing minerals, 5'-mono- and diphosphates also form selectively in one-pot reactions.

36 dine nucleosides, which represent nucleoside diphosphate analogues, and compared their CD73 inhibitor

37 Nucleoside analogs such as gemcitabine diphosphate and clofarabine nucleotides target the large

38 r two universal building blocks, isopentenyl diphosphate and dimethylallyl diphosphate, was thought t

39 uced aggregation in response to adenosine 5'-diphosphate and epinephrine, but variable aggregation de

40 y, tolerating a number of substitutions, and diphosphate and monophosphate analogues display very lit

41 ommencing with the substrate geranyl geranyl diphosphate and terminating with the carbocation precurs

42 telet reactivity were similar with adenosine diphosphate and thrombin.

43 n increased maximum response to adenosine 5'-diphosphate and TxA2, and a greatly exaggerated response

44 urinergic receptors activated by adenosine 5-diphosphate and UDP-sugars, respectively-were upregulate

45 is critical for the synthesis of polyprenol diphosphates and cellular function.

46 ans-prenyl diphosphates, some use cis-prenyl diphosphates and some use both.

47 rprisingly, can instead hydrolyze nucleoside diphosphates and triphosphates, which may play a role in

48 Soluble apyrase reduced renal ATP, adenosine diphosphate, and adenosine monophosphate, but not adenos

49 nformations upon binding to GTP or guanosine diphosphate, and that the Parkinson's disease (PD)-assoc

50 uli to arachidonic acid, collagen, adenosine diphosphate, and thrombin as secondary endpoints.

51 o PRPP, to NAD(+), to adenosine and cytidine diphosphates, and to precursors of thiamine biosynthesis

52 is a flavin adenine dinucleotide-, thiamine diphosphate- and magnesium-dependent enzyme that catalys

53 is(2,4-di- tert-butylphenyl) pentaerythritol diphosphate (AO626=O(2)), and trisnonylphenol phosphate

54 g mode of adenosine 5'-(alpha,beta-methylene)diphosphate (AOPCP) with human CD73, we designed a serie

55 a enzymes using the 20-carbon geranylgeranyl diphosphate are known from other plant families, having

56 Compared with the use of 3,6-fluorescein diphosphate as a signal reporter in an ALP-linked immuno

57 ed synthesis of sesquiterpenes from farnesyl diphosphate as high-value natural products with applicat

58 ylgeranyl diphosphate (GGPP) and isopentenyl diphosphate as substrates.

59 TPS enzymes accept ubiquitous prenyl diphosphates as substrates and convert them into the var

60 th proton abstraction being achieved using a diphosphate-Asn-Ser relay.

61 ntial routes for the evolution of nucleoside diphosphate beta-l-Rha (NDP-beta-l-Rha) pathways among a

62 The phosphate and diphosphate binding of the generated channels was studie

63 ion, identifying dysregulated geranylgeranyl diphosphate biosynthesis as a potential disease mechanis

64 te, monostarch monophosphate, and monostarch diphosphate, but significantly increased distarch monoph

65 santhemol in addition to trans-chrysanthemyl diphosphate, but the enzymes responsible for the convers

66 where glycans are completed on undecaprenyl diphosphate carriers at the cytosol:membrane interface,

67 nt-CPP) synthase SdCPS1, and the clerodienyl diphosphate (CLPP) synthase SdCPS2.

68 We found that chloroquine diphosphate (CLQ), an antimalarial drug, inhibits Burkho

69 Tenofovir diphosphate concentrations in dried blood spots were sta

70 ng-term adherence, as evidenced by tenofovir diphosphate concentrations in dried blood spots.

71 ective for the cell by regulating isoprenoid diphosphate concentrations so that they are maintained b

72 u from the guanosine triphosphate to guanine diphosphate conformation during aa-tRNA accommodation.

73 crobial infections and malignancy by sensing diphosphate-containing metabolites called phosphoantigen

74 clases that produce the intermediate copalyl diphosphate (CPP), along with the more surprising findin

75 s the "irregular" monoterpenes chrysanthemyl diphosphate (CPP), lavandulyl diphosphate (LPP), and tra

76 ol diphosphate (LPP, TcCPS2) and (+)-copalyl diphosphate (CPP, TcCPS4), and three class-I diTPSs prod

77 cking conserved motifs required for farnesyl diphosphate cyclase activity.

78 xy-hydrolysis products [2-deoxy-adenosine 5'-diphosphate (dADP) and inorganic phosphate (Pi)] bound t

79 The final enzyme in this pathway, mevalonate diphosphate decarboxylase (MDD), acts on mevalonate diph

80 nal and structural studies on the mevalonate diphosphate decarboxylase from E. faecalis (MDDEF).

81 Mevalonate diphosphate decarboxylases (MDDs) catalyze the ATP-depen

82 fluxes during episodes of organellar thiamin diphosphate deficiency.

83 se domain-containing protein 1) is a thiamin diphosphate-dependent enzyme and part of the 2-oxoadipat

84 iosynthesis is catalyzed by MenD, a thiamine diphosphate-dependent enzyme comprising three domains.

85 us quantification of thiamine, its mono- and diphosphate derivatives and its precursors 4-methyl-5-(2

86 peroxisomes into microfactories for geranyl diphosphate-derived compounds, focusing on monoterpenoid

87 termediate alpha,beta-dihydroxyethylthiamine diphosphate (DHEThDP) within the enzymatic active site.

88 , which cannot synthesize PE by the cytidine diphosphate diacylglycerol (CDP-DAG) pathway, is avirule

89 al species, is the reaction between cytidine diphosphate-diacylglycerol and inositol-phosphate to yie

90 PS-c subfamily were characterized as copalyl diphosphate (diterpene) synthases, and those belonging t

91 opentenyl diphosphate (IPP) to dimethylallyl diphosphate (DMAPP) and then to geranyl diphosphate (GPP

92 ranyl diphosphate [GPP] versus dimethylallyl diphosphate [DMAPP]) with a single amino acid change.

93 the de novo synthesis of deoxyribonucleoside diphosphates (dNDPs) to provide dNTP precursors for DNA

94 action in all domains of life wherein prenyl diphosphate donors transfer prenyl groups onto small mol

95 (BP), tenofovir (TFV) in SP and BP, and TFV-diphosphate (dp) in peripheral blood mononuclear cells (

96 e (7-deaza-G), and 7-methylguanosine (m(7)G) diphosphates efficiently accepted pRNA, resulting in the

97 f polyketide phenol nucleophiles and terpene diphosphate electrophiles.

98 iterpene synthases (diTPSs), the ent-copalyl diphosphate (ent-CPP) synthase SdCPS1, and the clerodien

99 tential and adenosine triphosphate/adenosine diphosphate failed to reach a new steady state following

100 GDP synthase (GGDPS) that condenses farnesyl diphosphate (FDP) and isopentenyl pyrophosphate.

101 from its natural substrate (2E,6E)-farnesyl diphosphate (FDP).

102 A 5'-diphosphate form of antiviral ribavirin weakly inhibited

103 sizes the "regular" sesquiterpenoid farnesyl diphosphate (FPP) by coupling isopentenyl diphosphate (I

104 wild-type galactosyltransferase and uridine diphosphate galactose (UDP-Gal) for global and site-spec

105 resulted into identification of guanosine 5'-diphosphate (GDP) as a promising hepcidin-binding agent.

106 at is present only in the inactive guanosine diphosphate (GDP)-bound form of KRAS(G12C), sparing the

107 a modest preference for GTP- over guanosine diphosphate (GDP)-bound MT lattice and competes with end

108 ROUND & AIMS: De novo synthesis of guanosine diphosphate (GDP)-fucose, a substrate for fucosylglycans

109 ear C25 isoprenoid precursor geranylfarnesyl diphosphate (GFPP) defines sesterterpene scaffolds.

110 eranylgeranylation reactions, geranylgeranyl diphosphate (GGDP), is the product of the enzyme GGDP sy

111 ly 55 carbons in length using geranylgeranyl diphosphate (GGPP) and isopentenyl diphosphate as substr

112 current study identifies C20 geranylgeranyl diphosphate (GGPP) as a precursor for lycopaoctaene bios

113 production of monoterpene and geranylgeranyl diphosphate (GGPP) diversities, and plant morphology by

114 Geranylgeranyl diphosphate (GGPP), a prenyl diphosphate synthesized by

115 sphocreatine, inorganic phosphate, adenosine diphosphate, Gibbs free energy of ATP hydrolysis (DeltaG

116 ted activity towards quercetin and adenosine diphosphate glucose (ADPG), kaempferol and UDPG, quercet

117 , revealed that H23 bound within the uridine diphosphate glucose binding pocket of yGsy2p.

118 no heritable factors associated with uridine diphosphate glucuronyl transferase 2B7 metabolism of mor

119 Despite the importance of uridine diphosphate glycosyltransferase (UGT) enzymes in drug an

120 Candidate uridine-diphosphate glycosyltransferase genes (UGTs) were select

121 It is mediated by uridine-diphosphate glycosyltransferases (UGTs), that achieve th

122 ch in M. truncatula In addition, two uridine diphosphate glycosyltransferases, UGT73F18 and UGT73F19,

123 genes, which encode seed-specific uridine 5'-diphosphate-glycosyltransferases.

124 h are derived from linear precursors geranyl diphosphate (GPP) and lavandulyl diphosphate (LPP), resp

125 yzing the irreversible conversion of geranyl diphosphate (GPP) to geraniol.

126 MoeN5 catalyzes the reaction of geranyl diphosphate (GPP) with the cis-farnesyl group in phospho

127 llyl diphosphate (DMAPP) and then to geranyl diphosphate (GPP).

128 their isoprene donor specificities (geranyl diphosphate [GPP] versus dimethylallyl diphosphate [DMAP

129 analog of (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate (HMBPP) bound to BTN3A1 with intermediate af

130 s, such as (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate (HMBPP), are ligands of the internal domain

131 detection was carried out using hydroquinone diphosphate (HQDP) as enzymatic substrate.

132 gram for Kenyan women, we detected tenofovir-diphosphate in 61% (125/201) of randomly selected dried

133 ; thiamin, thiamin monophosphate and thiamin diphosphate in bovine milk.

134 repeatedly high concentrations of tenofovir diphosphate in dried blood spots.

135 adherence, and measured levels of tenofovir diphosphate in dried blood spots; and (3) examine patter

136 '-diphosphate trisodium salt and MRS2365 (5'-diphosphates) in some signaling events, such as extracel

137 Ras into inactive Ras is bound to guanosine diphosphate, inactivating Ras.

138 ed toxicity in vitro and show that tenofovir-diphosphate incorporation by PrimPol is dependent on the

139 metabolite of tenofovir prodrugs, tenofovir-diphosphate, inhibited the incorporation of dATP into a

140 This could be prevented by guanosine 5'-diphosphate inhibition of UCP1.

141 tations to charged surface residues impacted diphosphate interactions.

142 catalysed the cyclisation of geranylgeranyl diphosphate into 11-hydroxy vulgarisane, the likely bios

143 diTPS PxaTPS8, which converts geranylgeranyl diphosphate into a previously unknown 5,7-fused bicyclic

144 yl diphosphate (FPP) by coupling isopentenyl diphosphate (IPP) to dimethylallyl diphosphate (DMAPP) a

145 The mevalonate pathway produces isopentenyl diphosphate (IPP), a building block for polyisoprenoid s

146 5-diphosphate (MVAPP) to produce isopentenyl diphosphate (IPP), which is essential in both eukaryotes

147 in nature are all derived from the 5-carbon diphosphates isopentenyl pyrophosphate (IPP) and dimethy

148 lipids but does not transport a glycosylated diphosphate isoprenoid lipid.

149 , Rhomboid protein 1 (Rom 1), and nucleoside diphosphate kinase (NDK).

150 ein kinase activity but retaining nucleoside diphosphate kinase (NDPK) activity showed that the NDPK

151 matic activities of mitochondrial nucleoside diphosphate kinase (NDPK) in prostate cancer cells.

152 the deregulation of mitochondrial nucleoside diphosphate kinase (NDPK) together with defects in mitoc

153 a new phagocytic function for the nucleoside diphosphate kinase 1 (NDK-1), the nematode counterpart o

154 tosis due to the induction of the nucleoside diphosphate kinase Abnormal Wing Disc (AWD).

155 ylates the catalytic histidine on nucleoside diphosphate kinase B (NDPK-B).

156 ncreatic Zn(2+) (hZnT8WT) induced nucleoside diphosphate kinase B, and Zn(2+) reduction (hZnT8RW) ind

157 cells, an effect regulated by the nucleoside diphosphate kinase ndk-1.

158 The nucleoside diphosphate kinase NDK-1/NME1 promotes phagocytosis in c

159 e, we characterized the M. oryzae nucleoside diphosphate kinase-encoding gene NDK1 and discovered it

160 Nucleoside diphosphate kinases (NDKs) play a central role in divers

161 Nucleoside diphosphate kinases (NDPKs) are enriched at the plasma m

162 Tenofovir diphosphate levels consistent with a high degree of anti

163 lyze the metabolite cap substrate within the diphosphate linkage.

164 ping by recombinant NUDT3 (Nudix [nucleoside diphosphate linked moiety X]-type hydrolase 3) in vitro.

165 es that catalyze the formation of polyprenol diphosphate-linked glycans via phosphosugar transfer fro

166 chrysanthemyl diphosphate (CPP), lavandulyl diphosphate (LPP), and trace quantities of maconelliyl d

167 ors geranyl diphosphate (GPP) and lavandulyl diphosphate (LPP), respectively.

168 al class-II enzymes forming labda-13-en-8-ol diphosphate (LPP, TcCPS2) and (+)-copalyl diphosphate (C

169 lation intermediate, C2-alpha-lactyl-thiamin diphosphate (LThDP), which has subsequent decarboxylatio

170 iquely by the combination of an adenosine 5'-diphosphate molecule with no magnesium ion plus phosphat

171 Nonetheless, PMGN diphosphate monomers were recognized as substrates by Es

172 ed cyanostar macrocycle and phenylene-linked diphosphate monomers.

173 e (LPP), and trace quantities of maconelliyl diphosphate (MPP) from two molecules of DMAPP, and coupl

174 hate decarboxylase (MDD), acts on mevalonate diphosphate (MVAPP) to produce IPP while consuming ATP.

175 ndent-Mg(2+)-decarboxylation of mevalonate-5-diphosphate (MVAPP) to produce isopentenyl diphosphate (

176 urses of (13)C isotopologue data for uridine diphosphate N-acetyl-D-glucosamine (UDP-GlcNAc) in human

177 6-phosphate to eventually synthesize uridine diphosphate N-acetylglucosamine (UDP-GlcNAc).

178 synthetic pathway (HBP), to increase uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc).

179 period, (13)C was incorporated into nucleic diphosphate (NDP) sugars in 4 h, and (13)C labelled peak

180 We show here that ribonucleoside-5'-diphosphates (NDPs) can be utilized as substrates by RNA

181 sibly transfer phosphate groups from tri- to diphosphate nucleosides.

182 The finding that the diphosphates of the compounds developed in this study ar

183 zation pathway (IUP) can produce isopentenyl diphosphate or dimethylallyl diphosphate, the main precu

184 is commonly dictated by binding to guanosine diphosphate or guanosine triphosphate.

185 f radial access and novel platelet adenosine diphosphate P2Y12 receptor inhibitors.

186 t of some compounds related with the geranyl-diphosphate pathway (neryl and geranyl acetates) and som

187 pp, pppGpp and guanosine 5'-monophosphate 3'-diphosphate (pGpp) (collectively (pp)pGpp) turnover, inc

188 hird alarmone, guanosine-5'-monophosphate-3'-diphosphate (pGpp), with less-clear functions.

189 e possible targets: YubA, YubB (undecaprenyl diphosphate phosphatase (UPPP)), and YubD.

190 absence of l-alpha-phosphatidylinositol 4,5-diphosphate (PIP2).

191 to reduced isoprene substrate dimethylallyl diphosphate pool size.

192 Inositol diphosphates (PP-IPs), also known as inositol pyrophosph

193 cidated roles of guanosine 5'-diphosphate 3'-diphosphate (ppGpp) in transcription elongation that cou

194 A 2:1 stoichiometry between macrocycle and diphosphate produces a supramolecular homopolymer of gen

195 of the disease, early treatment of adenosine diphosphate receptor antagonists at presentation, older

196 s the antiplatelet effects of oral adenosine diphosphate receptor blockers.

197 nts enrolled in the Treatment With Adenosine Diphosphate Receptor Inhibitors: Longitudinal Assessment

198 sing TRANSLATE-ACS (Treatment With Adenosine Diphosphate Receptor Inhibitors: Longitudinal Assessment

199 RANSLATE-ACS study (Treatment With Adenosine Diphosphate Receptor Inhibitors: Longitudinal Assessment

200 Cangrelor is a potent intravenous adenosine diphosphate-receptor antagonist that in the CHAMPION tri

201 f DMAPP:IPP produced by hydroxymethylbutenyl diphosphate reductase (HDR/IspH), the final step of the

202 osine triphosphate (GTP) turnover, guanosine diphosphate release, GTP binding, and G protein dissocia

203 fluid and its intracellular metabolite (TFV diphosphate) revealed that TDF PrEP efficacy was best de

204 It metabolizes NAD(+) to adenosine diphosphate ribose (ADPR) and cyclic ADPR, regulating se

205 Binding of the nucleotide adenosine 5'-diphosphate ribose (ADPR) to the cytosolic NUDT9 homolog

206 ng messengers, including cyclic adenosine 5'-diphosphate ribose (cADPR), and CD38 knockout studies ha

207 cells through an IL-13-CD38-cyclic adenosine diphosphate ribose (cADPR)-dependent process.

208 is, analogues based on the cyclic inosine 5'-diphosphate ribose (cIDPR) template were synthesised.

209 We identify a variant of cyclic adenosine diphosphate ribose as a biomarker of TIR enzymatic activ

210 ium-permeable channel activated by adenosine diphosphate ribose metabolites and oxidative stress.

211 ethods: We used a radiolabled poly(adenosine diphosphate ribose) polymerase (PARP) inhibitor called (

212 tive radiosensitizers such as poly(adenosine diphosphate ribose) polymerase and mammalian-target-of-r

213 dependent protein kinase, and poly[adenosine diphosphate ribose] polymerase (PARP) 1/2.

214 ding to the crystal structure of adenosine-5-diphosphate-ribose (ADP-ribose) in complex with non-phos

215 Poly-adenosine diphosphate-ribose polymerases (PARPs) promote ADP-ribos

216 itrotyrosine (marker of RNS), poly(adenosine diphosphate-ribose) (PAR, marker of PARP activation) and

217 e associated with response to poly(adenosine diphosphate-ribose) polymerase (PARP) inhibition in pati

218 elial ovarian cancer (EOC) to poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitor in a CAR

219 Poly(adenosine 5'-diphosphate-ribose) polymerase (PARP) inhibitors are a c

220 ective clinical trial of the poly-(adenosine diphosphate-ribose) polymerase inhibitor olaparib in mCR

221 pendent kinase inhibitors and poly(adenosine diphosphate-ribose) polymerase inhibitors.

222 nts it from inhibiting PARP1 [poly(adenosine diphosphate-ribose) polymerase], a critical DNA repair p

223 race (FTT) depicts activated poly (adenosine diphosphate-ribose)polymerase (PARP) expression and is f

224 The poly(adenosine diphosphate-ribose)polymerase (PARP) family of enzymes i

225 L, a fluorescent inhibitor of poly[adenosine diphosphate-ribose]polymerase 1 (PARP1), which is a nucl

226 in, and harbored arr-3, a rifampin adenosine diphosphate-ribosyl transferase.

227 he phosphorylated state with the adenosine-5-diphosphate-ribosylarginine (ADP-RA) complex (51.56%) th

228 with and regulates the activity of adenosine diphosphate ribosylation factor 6 (ARF6), a small G prot

229 e (AC) in response to CT is due to adenosine diphosphate ribosylation of the small G protein alpha-su

230 th the wild-type immunotoxin in an adenosine diphosphate-ribosylation assay.

231 on to endocytosis and show that adenosine 5'-diphosphate-ribosylation factor 6 (Arf6) plays a key rol

232 d diterpene synthases, some use trans-prenyl diphosphates, some use cis-prenyl diphosphates and some

233 omology, the phosphate-specific OprP and the diphosphate-specific OprO pores show structural differen

234 ns such as (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate stimulate human Vgamma9Vdelta2 T cells after

235 s were found to be active on multiple prenyl-diphosphate substrates with different chain lengths and

236 regulate RR specificity among its nucleoside diphosphate substrates.

237 Small isoprenoid diphosphates, such as (E)-4-hydroxy-3-methyl-but-2-enyl

238 via phosphosugar transfer from a nucleotide diphosphate-sugar to a polyprenol phosphate.

239 Chrysanthemyl diphosphate synthase (CDS), the first enzyme involved in

240 hosphate synthase (FPPase) and chrysanthemyl diphosphate synthase (CPPase) from Artemisia tridentata

241 RP) and c.124A>G, p.K42E in dehydrodolichol diphosphate synthase (DHDDS) (33%).

242 Farnesyl diphosphate synthase (FDPS), a mevalonate pathway enzyme

243 The amino acid sequences of farnesyl diphosphate synthase (FPPase) and chrysanthemyl diphosph

244 ive ILTPSs that belong to the geranylgeranyl diphosphate synthase (GGDPS) family of IDSs were identif

245 lopment of inhibitors against geranylgeranyl diphosphate synthase (GGDPS), which generates the isopre

246 Geranylgeranyl diphosphate synthase (GGPPS) is a central metalloenzyme

247 hosphonates are inhibitors of geranylgeranyl diphosphate synthase (GGPPS), a metalloenzyme crucial fo

248 , in transgenic tobacco by elevating geranyl diphosphate synthase (GPS) activity.

249 diphosphate synthase (LiGGPPS) and farnesyl diphosphate synthase (LiFPPS).

250 iphosphate synthase (LiGPPS), geranylgeranyl diphosphate synthase (LiGGPPS) and farnesyl diphosphate

251 avandula x intermedia cDNAs encoding geranyl diphosphate synthase (LiGPPS), geranylgeranyl diphosphat

252 nthase (SlDXS), Arabidopsis thaliana geranyl diphosphate synthase 1 (AtGPS) and Mentha x piperita ger

253 ynthesis, 1-hydroxy-2-methyl-2-(E)-butenyl-4-diphosphate synthase and 4-amino-5-hydroxymethyl-2-methy

254 we identified a neo-cleroda-4(18),13E-dienyl diphosphate synthase from Ajuga reptans, catalyzing the

255 te pathway were overexpressed, and a geranyl diphosphate synthase from the plant Abies grandis was ex

256 s to pitavastatin is potentiated by farnesyl diphosphate synthase inhibitors or geranylgeraniol trans

257 hase 1 (AtGPS) and Mentha x piperita geranyl diphosphate synthase small subunit (MpGPS.SSU) on produc

258 Both UPPP as well as undecaprenyl diphosphate synthase were inhibited by compound 1.

259 ing of NgBR (Nus1) and hCIT (dehydrodolichol diphosphate synthase) subunits, and this composition has

260 e homodimeric bacterial enzyme, undecaprenyl diphosphate synthase, generates 11 isoprene units and ha

261 ddle" prenyltransferase, isosesquilavandulyl diphosphate synthase, involved in biosynthesis of the me

262 ntly, we discovered that unlike undecaprenyl diphosphate synthase, mammalian cis-PT is a heteromer co

263 nts the presence of a short-chain cis-prenyl diphosphate synthase, previously only found in Solanacea

264 e long-chain trans-polyisoprene via farnesyl diphosphate synthases (FPSs).

265 Terpene synthases (TPSs) and trans-isoprenyl diphosphate synthases (IDSs) are among the core enzymes

266 hosphate (MEP) pathway genes, geranylgeranyl diphosphate synthases 3 (GGPPS3) and GGPPS4.

267 the catalytic base group in the ent-copalyl diphosphate synthases found in all seed plants for gibbe

268 tion of cDNAs encoding short-chain isoprenyl diphosphate synthases that control the partitioning of p

269 (e.g. cis-farnesyl, decaprenyl, undecaprenyl diphosphate synthases), the large, hydrophobic side chai

270 Geranylgeranyl diphosphate (GGPP), a prenyl diphosphate synthesized by GGPP synthase (GGPS), represe

271 The disposition of tenofovir diphosphate (TFV-DP) and emtricitabine triphosphate (FTC

272 Intracellular tenofovir diphosphate (TFV-DP) concentration measured in dried blo

273 the primary adherence outcome was tenofovir diphosphate (TFV-DP) concentrations >=700 fmol/punch (co

274 (TAF) on HIV infection and intracellular TFV-diphosphate (TFV-DP) concentrations in blood and genital

275 Tenofovir diphosphate (TFV-DP) concentrations in TGW and transgend

276 tial accumulation of intracellular Tenofovir diphosphate (TFV-DP) in different cell types, with great

277 Although tenofovir diphosphate (TFV-DP) in dried blood spots (DBS) is a pre

278 Tenofovir diphosphate (TFV-DP) in dried blood spots (DBS) is assoc

279 Tenofovir-diphosphate (TFV-DP) in red blood cells was used to cate

280 Median tenofovir diphosphate (TFV-DP) levels in peripheral blood mononucl

281 ow that when these herbicides bind, thiamine diphosphate (ThDP) is modified.

282 se 5-phosphate synthase (DXPS) uses thiamine diphosphate (ThDP) to convert pyruvate and d-glyceraldeh

283 S is unique among the superfamily of thiamin diphosphate (ThDP)-dependent enzymes in stabilizing the

284 al fluid, tenofovir in plasma, and tenofovir diphosphate, the active metabolite, in cervical tissue a

285 uce isopentenyl diphosphate or dimethylallyl diphosphate, the main precursors to isoprenoid synthesis

286 tary ATP synthase to phosphorylate adenosine diphosphate to ATP.

287 From adenosine diphosphate to oxygen ratio measurements on preparations

288 ro, HpRppH converts RNA 5'-triphosphates and diphosphates to monophosphates.

289 onse curves of both 2-methylthioadenosine 5'-diphosphate trisodium salt and MRS2365 (5'-diphosphates)

290 reversible conversion of sucrose and uridine diphosphate (UDP) into fructose and UDP-glucose, is a ke

291 Uridine diphosphate (UDP)-activated purinergic receptor P2Y(6) (

292 eries of glycosylations catalyzed by uridine diphosphate (UDP)-dependent glucosyltransferases.

293 ynthesize the nucleotide-sugar donor uridine diphosphate (UDP)-GalNAzMe from a sugar-1-phosphate prec

294 Unnatural uridine diphosphate (UDP)-sugar donors, UDP-4-deoxy-4-fluoro-N-a

295 Tenofovir-diphosphate was detected more frequently among women who

296 s, isopentenyl diphosphate and dimethylallyl diphosphate, was thought to proceed exclusively by way o

297 These modified diphosphates were used with terpene synthases to produce

298 t to conserved Ser, comes close to the HMBPP diphosphate, whereas double mutation of nonconserved res

299 uces the rare diterpene precursor nerylneryl diphosphate, which is cyclized by an unusual plastidial

300 a coli, and demonstrated to cyclize farnesyl diphosphate, yielding beta-selinene as the dominant prod