ライフサイエンスコーパス: diphtheriae

1 uberculosis) and diphtheria (Corynebacterium diphtheriae).

2 gnition of the toxin gene in Corynebacterium diphtheriae.

3 mmalian HO-1 and the HO from Corynebacterium diphtheriae.

4 antigenically distinct from other pili of C. diphtheriae.

5 sights into transcriptional regulation in C. diphtheriae.

6 he SpaABC pili and possibly other pili of C. diphtheriae.

7 n linked to the virulence of Corynebacterium diphtheriae.

8 iosynthesis and transport in Corynebacterium diphtheriae.

9 esent a potential reservoir for toxigenic C. diphtheriae.

10 tatic and virulence genes in Corynebacterium diphtheriae.

11 nes were constructed on the chromosome of C. diphtheriae.

12 of known virulence genes in Corynebacterium diphtheriae.

13 disease caused by toxigenic Corynebacterium diphtheriae.

14 ed the precise amount of DtxR per cell in C. diphtheriae.

15 than another studied HO from Corynebacterium diphtheriae.

16 l of iron-sensitive genes in Corynebacterium diphtheriae.

17 l ion-activated repressor in Corynebacterium diphtheriae.

18 cobacterium tuberculosis and Corynebacterium diphtheriae.

19 ecretion of diphtheria toxin by wild-type C. diphtheriae.

20 n(2+) transport systems may be present in C. diphtheriae.

21 egulated promoters (IRPs) in Corynebacterium diphtheriae.

22 loregulatory proteins to be identified in C. diphtheriae.

23 t time that dtxR is a dispensable gene in C. diphtheriae.

24 tem previously identified in Corynebacterium diphtheriae.

25 nose swab to be positive for Corynebacterium diphtheriae.

26 mmunicable disease caused by Corynebacterium diphtheriae.

27 ane when expressed in Escherichi coli and C. diphtheriae.

28 infectious disease caused by Corynebacterium diphtheriae.

29 nd may function as the haemin receptor in C. diphtheriae.

30 d the need for laboratories to screen for C. diphtheriae.

31 ay a crucial role in the pathogenicity of C. diphtheriae.

32 in from toxigenic strains of Corynebacterium diphtheriae.

33 emoglobin as iron sources by Corynebacterium diphtheriae.

34 negative global regulator in Corynebacterium diphtheriae.

35 ease caused by the bacterium Corynebacterium diphtheriae.

36 cobacterium tuberculosis and Corynebacterium diphtheriae.

37 scheme, which is currently restricted to C. diphtheriae.

38 the general oxidative folding machine in C. diphtheriae.

39 n-mediated disease caused by Corynebacterium diphtheriae.

40 al host iron sources that are utilized by C. diphtheriae.

41 -TOF MS) were conclusive for Corynebacterium diphtheriae.

42 ad no effect on hemin iron utilization in C. diphtheriae.

43 virulence and other genes in Corynebacterium diphtheriae.

44 se reaction intermediates in Corynebacterium diphtheriae.

45 nction as cell surface hemin receptors in C. diphtheriae.

46 currently the method of choice for typing C. diphtheriae.

47 h ferrous ion homeostasis in Corynebacterium diphtheriae.

48 of the regulation of heme homeostasis in C. diphtheriae.

49 onsillectomy and immunity to Corynebacterium diphtheriae (1931), 2 papers from a longitudinal study o

50 r the clinically significant Corynebacterium diphtheriae (4 of 4) and Corynebacterium jeikeium (8 of

51 erium haemolyticum (8%), and Corynebacterium diphtheriae (8%).

52 To further define the DtxR regulon in C. diphtheriae, a DtxR repressor titration assay (DRTA) was

53 release measurements are compatible with C. diphtheriae acquiring heme passively released from hemog

54 t safeguards oxidative protein folding in C. diphtheriae against thermal stress.

55 ria toxin (Dtx) expressed by Corynebacterium diphtheriae also can function as part of an anti-predato

56 imed to describe the outbreak of toxigenic C diphtheriae among asylum seekers arriving by small boats

57 me oxygenase mutants of both Corynebacterium diphtheriae and C. ulcerans fail to use heme as an iron

58 C. diphtheriae and C. ulcerans mutants defective in haemin

59 espiratory illness caused by Corynebacterium diphtheriae and C. ulcerans, and use of diphtheria anti-

60 etions in the hmuO gene from Corynebacterium diphtheriae and Corynebacterium ulcerans and show that t

61 Nontoxigenic Corynebacterium diphtheriae and Corynebacterium ulcerans cause invasive

62 Mutants of C. diphtheriae and Corynebacterium ulcerans that are defect

63 Corynebacterium diphtheriae and Corynebacterium ulcerans use haemin and

64 ection caused by a nontoxigenic strain of C. diphtheriae and discuss the epidemiology, possible sourc

65 of the SpaA-type pilus from Corynebacterium diphtheriae and FimA of the type 2 pilus from Actinomyce

66 m the gram-positive pathogen Corynebacterium diphtheriae and for eukaryotic heme oxygenases.

67 inc specific transcriptional regulator in C. diphtheriae and give new insights into the intricate reg

68 are and contrast galactan biosynthesis in C. diphtheriae and M. tuberculosis In each species, the gal

69 n of amino acids, as well as Corynebacterium diphtheriae and Mycobacterium tuberculosis, which cause

70 lts of this work provide insight into how C. diphtheriae and other pathogenic and commensal corynebac

71 diphthamide, the target for Corynebacterium diphtheriae and Pseudomonas aeruginosa toxins.

72 d by a lack of molecular genetic tools in C. diphtheriae and related Coryneform species.

73 utilization of heme as an iron source by C. diphtheriae and that the heme oxygenase activity of HmuO

74 , the heterotrimeric pili in Corynebacterium diphtheriae and the heterodimeric pili in Actinomyces or

75 -based mutagenesis technique for use with C. diphtheriae, and we used it to construct the first trans

76 Diagnostic tests for toxinogenicity of C. diphtheriae are based either on immunoassays or on bioas

77 cobacterium tuberculosis and Corynebacterium diphtheriae are characterized by their complex, multi-la

78 We show here that pili of Corynebacterium diphtheriae are composed of three pilin subunits, SpaA,

79 Numerous, highly diverse clusters of C. diphtheriae are observed across the phylogeny, each cont

80 ix sortase genes encoded in the genome of C. diphtheriae are required for precursor processing, pilus

81 toxin repressor (DtxR) from Corynebacterium diphtheriae, are iron-dependent regulatory proteins that

82 Corynebacterium diphtheriae assembles on its surface three distinct pilu

83 ing classified the strain as nontoxigenic C. diphtheriae biotype Gravis.

84 ncing to determine the genome sequence of C. diphtheriae BQ11 and mechanism of beta-lactam resistance

85 ncing to determine the genome sequence of C. diphtheriae BQ11 and the mechanism of B-lactam resistanc

86 cobacterium tuberculosis and Corynebacterium diphtheriae, but unlike the linear chromosomes of the mo

87 new IRP, designated IRP6, was cloned from C. diphtheriae by a SELEX-like procedure.

88 1 was toxigenic and 3 were non-toxigenic C. diphtheriae by culture and Elek, 6 were culture-negative

89 , 1 was toxigenic and 3 were nontoxigenic C. diphtheriae by culture and Elek, 6 were culture-negative

90 Inactivation of hmuT in C. diphtheriae by site-specific recombination had no effect

91 ia cases caused by toxigenic Corynebacterium diphtheriae (C diphtheriae) was reported among asylum se

92 ized with either pentavalent Corynebacterium diphtheriae C7 (beta197) cross-reactive material (CRM197

93 operon contained a large deletion in the C. diphtheriae C7 strain, but the sid genes were unaffected

94 C. diphtheriae C7(-) acquired iron from heme, hemoglobin, a

95 d under high-iron conditions in wild-type C. diphtheriae C7(beta), but they were expressed constituti

96 In C. diphtheriae C7, optimal expression from the hmuO promote

97 xR(E175K) mutant allele from Corynebacterium diphtheriae can be expressed in Mycobacterium tuberculos

98 Unlike other Cas9 orthologs, Corynebacterium diphtheriae Cas9 (CdCas9) recognizes the promiscuous NNR

99 None of the eight C. diphtheriae cases were fully immunized.

100 ation enzyme in the pathogen Corynebacterium diphtheriae, catalyzes the oxygen-dependent conversion o

101 Toxigenic strains of Corynebacterium diphtheriae cause respiratory diphtheria.

102 Corynebacterium diphtheriae causes diphtheria, a potentially fatal infec

103 Corynebacterium diphtheriae causes the life-threatening respiratory dise

104 eted by lysogenic strains of Corynebacterium diphtheriae, causes the disease diphtheria in humans by

105 tants in heme oxygenase from Corynebacterium diphtheriae (cd-HO).

106 reductase A of the pathogen Corynebacterium diphtheriae (Cd-MsrA) and shown that this enzyme is coup

107 r-lacZ fusion was dependent on the cloned C. diphtheriae chrA and chrS genes (chrAS), which encode th

108 In this study, two clones isolated from a C. diphtheriae chromosomal library were shown to activate t

109 ephages are capable of inserting into the C. diphtheriae chromosome at two specific sites, attB1 and

110 each of these systems was cloned from the C. diphtheriae chromosome, and constructs each carrying one

111 organism showed that several genotypes of C. diphtheriae circulated on different continents of the wo

112 ed the predominant strain of nontoxigenic C. diphtheriae circulating in the United Kingdom to see if

113 C. diphtheriae ciuE deletion mutants exhibited a defect in

114 Corynebacterium diphtheriae clade species secrete single-domain endo-bet

115 e, we characterized a large collection of C. diphtheriae clinical isolates for their pilin gene pool

116 ered to be non-pathogenic, outside of the C. diphtheriae complex.

117 he findings from this study indicate that C. diphtheriae contains at least 18 DtxR binding sites and

118 The genome of Corynebacterium diphtheriae contains three pilus gene clusters, two of w

119 ief has been disproven with many notable non-diphtheriae Corynebacterium species being found to be pa

120 toxin gene CRM197 allele in Corynebacterium diphtheriae culture DNA samples.

121 e complemented the mutant phenotypes of a C. diphtheriae DeltadtxR strain.

122 al DtxR-regulated promoter/operators from C. diphtheriae designated IRP3, IRP4, and IRP5.

123 aR, with 26% identity to the Corynebacterium diphtheriae diphtheria toxin repressor (DtxR).

124 ein distantly related to the Corynebacterium diphtheriae diphtheria toxin repressor (DtxR).

125 In Corynebacterium diphtheriae, diphtheria toxin is encoded by the tox gene

126 Although C. diphtheriae does not depend on other actinomycetal genes

127 Corynebacterium diphtheriae DtxR is an iron-specific repressor of diphth

128 omologous to elements of the Corynebacterium diphtheriae DtxR regulon, which controls, in response to

129 In Corynebacterium diphtheriae, DtxR regulates not only the expression of d

130 tal-dependent regulator from Corynebacterium diphtheriae, DtxR.

131 Thus, C. diphtheriae employs a common sortase-catalysed mechanism

132 ings demonstrated that the irp6 operon in C. diphtheriae encodes a putative ABC transporter, that spe

133 Corynebacterium diphtheriae encodes six sortases, five of which are devo

134 egmatis (EsxA and EsxB), and Corynebacterium diphtheriae (EsxA and EsxB) are heterodimers and fold in

135 The Gram-positive pathogen Corynebacterium diphtheriae exports through the Sec apparatus many extra

136 o immune system-induced oxidative stress, C. diphtheriae expresses antioxidant enzymes, among which a

137 In this study, we describe a Corynebacterium diphtheriae ferric uptake regulator-family protein, Zur,

138 a heme degradation enzyme in Corynebacterium diphtheriae, forms a stoichiometric complex with iron pr

139 transporter involved in the protection of C. diphtheriae from hemin toxicity.

140 T-PCR assay to detect tox and distinguish C. diphtheriae from the closely related species C. ulcerans

141 resses the clone's origin and relation to C. diphtheriae from throughout Russia.

142 ts and on the results of experiments with C. diphtheriae genes cloned in Escherichia coli or analyzed

143 A search of the partially completed C. diphtheriae genome identified a gene, mntR, whose predic

144 A BLAST search of the C. diphtheriae genome identified a seven-gene cluster that

145 A BLAST search of the C. diphtheriae genome sequence revealed a second two-compon

146 The hrtAB genes are located on the C. diphtheriae genome upstream from the chrSA operon, which

147 Four clones from a C. diphtheriae genomic library complemented several of the

148 The C. diphtheriae GlfT2 gave rise to shorter polysaccharides t

149 on hemin utilization, which suggests that C. diphtheriae has an additional system for transporting he

150 olecular characterization of Corynebacterium diphtheriae has become a priority in order to be able to

151 ulation of endemic toxigenic Corynebacterium diphtheriae has been identified.

152 Corynebacterium diphtheriae has been shown to assemble a pilus structure

153 rom the pathogenic bacterium Corynebacterium diphtheriae has been subcloned and expressed in Escheric

154 iology of diseases caused by Corynebacterium diphtheriae has changed dramatically over the decades, a

155 f tools, genetic analysis of Corynebacterium diphtheriae has primarily relied on analysis of chemical

156 rom the pathogenic bacterium Corynebacterium diphtheriae, have been investigated by (1)H NMR spectros

157 txR mutant of C7, and in a hmuO mutant of C. diphtheriae HC1 provided further evidence that transcrip

158 nation and spin-state of the Corynebacterium diphtheriae heme oxygenase (Hmu O) and the proximal Hmu

159 l alpha-meso-hydroxylation of heme in the C. diphtheriae heme oxygenase-catalyzed reaction.

160 The Corynebacterium diphtheriae hmuO gene encodes a heme oxygenase that is i

161 The C. diphtheriae hmuO gene encodes a heme oxygenase that is i

162 Transcription of the Corynebacterium diphtheriae hmuO gene, which encodes a heme oxygenase in

163 n and heme whereas transcription from the C. diphtheriae hmuO promoter shows both significant iron re

164 ces from the mammalian HO-1 and bacterial C. diphtheriae HO structures, which suggests a structural b

165 endent activation at the hmuO promoter in C. diphtheriae; however, it was observed that significant l

166 report, we identify and characterize the C. diphtheriae hrtAB genes, which encode a putative ABC typ

167 Molecular subtyping of Corynebacterium diphtheriae identified significant genetic diversity wit

168 Five patients with C. diphtheriae IE were identified within 12 months at a Sea

169 ents (77%), including all 5 patients with C. diphtheriae IE, required hospital admission for C. dipht

170 h a proposed mechanism of hemin uptake in C. diphtheriae in which hemin is initially obtained from Hb

171 2015, and indicating silent circulation of C diphtheriae in Yemen before the outbreak was declared.

172 n of iron-sensitive genes in Corynebacterium diphtheriae, including the diphtheria toxin gene.

173 significant implications for treatment of C. diphtheriae infection and may lead to clinical failure.

174 Two (9.5%) cases died, one due to a C. diphtheriae infection and one due to C. ulcerans.

175 nerstone of the treatment of Corynebacterium diphtheriae infection for more than 100 years.

176 We assessed cases of toxigenic C. diphtheriae infection that were reported in 10 European

177 A surge of cases of Corynebacterium diphtheriae infection was observed in reception centers

178 ificant implications for the treatment of C. diphtheriae infection, and may lead to clinical failure.

179 The large number of C. diphtheriae infections among migrants is a cause for con

180 orted the improbability of importation of C. diphtheriae into this area and rather strongly suggest t

181 The use of hemin iron in C. diphtheriae involves the dtxR- and iron-regulated hmu he

182 erial IdeR, a homolog of the Corynebacterium diphtheriae iron regulator DtxR.

183 , represses transcription of Corynebacterium diphtheriae iron-regulated promoters in vivo and binds t

184 The Corynebacterium diphtheriae irp1 gene is negatively regulated by DtxR an

185 toxin repressor (DtxR) from Corynebacterium diphtheriae is a divalent metal-activated repressor of c

186 Corynebacterium diphtheriae is a Gram-positive, non-spore forming, non-m

187 Corynebacterium diphtheriae is a human pathogen that causes diphtheria.

188 of the pathogenic bacterium Corynebacterium diphtheriae is conferred by diphtheria toxin, whose expr

189 Transcription of the hmuO gene in C. diphtheriae is controlled under a dual regulatory mechan

190 DtxR of Corynebacterium diphtheriae is the best characterized of these important

191 iptional regulator DtxR from Corynebacterium diphtheriae is the prototype for a family of metal-depen

192 toxin repressor (DtxR) from Corynebacterium diphtheriae is the prototypic member of a superfamily of

193 The toxigenic C. diphtheriae isolate NCTC13129 produces three distinct he

194 A distinct clonal group of C. diphtheriae isolates (ET 8 complex) emerged in Russia in

195 we describe the genomic variation of 502 C. diphtheriae isolates across 16 countries and territories

196 e distribution of each genetic cluster of C. diphtheriae isolates across multiple countries in Europe

197 tion of 53 U.S. and Canadian Corynebacterium diphtheriae isolates by multilocus enzyme electrophoresi

198 In 2022, C diphtheriae isolates from 86 asylum seekers arriving by

199 tive composite transposon associated with C. diphtheriae isolates that dominated the diphtheria outbr

200 corynephages, and DT is only produced by C. diphtheriae isolates that harbor tox+ phages.

201 A total of 363 toxigenic C. diphtheriae isolates were identified among 362 patients

202 In a blinded test of 209 verified C. diphtheriae isolates, a 99.5% agreement with the standar

203 d for the differentiation of Corynebacterium diphtheriae isolates.

204 A C. diphtheriae mntA mutant grew as well as the wild type in

205 Here, we solved the solution structure of C. diphtheriae MsrB (Cd-MsrB) and unraveled its catalytic a

206 min iron utilization assays using various C. diphtheriae mutants indicate that deletion of the chtA-c

207 the C. ulcerans mutants and three of the C. diphtheriae mutants.

208 f important pathogens (e.g., Corynebacterium diphtheriae, Mycobacterium tuberculosis), and (iii) prov

209 tP site and the DIP0182 integrase gene of C. diphtheriae NCTC13129.

210 m were infected by toxigenic Corynebacterium diphtheriae of both mitis and gravis biotypes, showing t

211 Nontoxigenic Corynebacterium diphtheriae, often associated with wounds, can rarely ca

212 -regulated promoters in vivo and binds to C. diphtheriae operators in a metal-dependent manner in vit

213 eriae IE, required hospital admission for C. diphtheriae or a related condition.

214 m not only A. oris, but also Corynebacterium diphtheriae or Corynebacterium matruchotii.

215 he source of galactan length variation, a C. diphtheriae ortholog of the M. tuberculosis carbohydrate

216 l eight tox regions identical to those of C. diphtheriae Park-Williams No. 8 (tox type 1).

217 y was caused by one major clonal group of C. diphtheriae (PFGE type A, ribotype R1), which was identi

218 44 patients (median age, 44 years) had a C. diphtheriae-positive clinical culture, with most detecti

219 Most C. diphtheriae-positive cultures were polymicrobial, includ

220 heme and hemoglobin, which suggests that C. diphtheriae possesses a novel mechanism for utilizing he

221 Therefore, recent clinical isolates of C. diphtheriae produce a single antigenic type of DT, and d

222 Deletion of the hrtAB genes in C. diphtheriae produced increased sensitivity to hemin, whi

223 derophore, and several other Corynebacterium diphtheriae products.

224 Nontoxigenic strains of Corynebacterium diphtheriae represent a potential reservoir for the emer

225 of the Hb-Hp complex as an iron source by C. diphtheriae requires multiple iron-regulated surface com

226 The use of hemin iron by Corynebacterium diphtheriae requires the DtxR- and iron-regulated ABC he

227 Pilus assembly in C. diphtheriae requires the pilin motif and the C-terminal

228 f MdbA or a counterpart from Corynebacterium diphtheriae, rescues the Deltavkor mutant.

229 espiratory diphtheria caused by toxigenic C. diphtheriae resistant to penicillin and all other B-lact

230 espiratory diphtheria caused by toxigenic C. diphtheriae resistant to penicillin and all other beta-l

231 muO, the heme oxygenase from Corynebacterium diphtheriae, restores iron and heme levels, as well as A

232 dtxR genes in recent clinical isolates of C. diphtheriae revealed several tox alleles that encode ide

233 nematodes from infection by Corynebacterium diphtheriae, revealing the importance of this minor pool

234 rate that the cohort of CR domains within C. diphtheriae's hemin-uptake system have dissociation cons

235 thogenic bacteria, including Corynebacterium diphtheriae, Salmonella enterica, and Vibrio cholerae, a

236 C. diphtheriae secretes ChtA and HtaA hemophore proteins th

237 MR, and in situ binding measurements that C. diphtheriae selectively captures iron-loaded hemoglobin

238 Protein localization studies with C. diphtheriae showed that HtaA is associated predominantly

239 In the Yemen outbreak, C diphtheriae shows high phylogenetic, genomic, and phenot

240 on iron uptake or the utilization of the C. diphtheriae siderophore as an iron source.

241 ron uptake and reduced ability to use the C. diphtheriae siderophore as an iron source.

242 ved in the synthesis and transport of the C. diphtheriae siderophore.

243 Corynebacterium diphtheriae SpaA pili are composed of three pilin subuni

244 significant genetic diversity within the C. diphtheriae species, and ribotyping and MEE data general

245 ently, cell wall extracts of a particular C. diphtheriae strain (DSM43989) lacking mycolic acid ester

246 We report that an htaA deletion mutant of C. diphtheriae strain 1737 is unable to use the Hb-Hp compl

247 ae, FimA, is expressed in corynebacteria, C. diphtheriae strain NCTC13129 polymerized FimA to form sh

248 demic of 1993 to 1998 and 13 non-Georgian C. diphtheriae strains (10 Russian and 3 reference isolates

249 Sixty-six Corynebacterium diphtheriae strains (62 of the gravis biotype and 4 of t

250 n mostly caused by toxigenic Corynebacterium diphtheriae strains and occasionally by toxigenic C. ulc

251 Toxigenic Corynebacterium diphtheriae strains cause diphtheria in humans.

252 One hundred fifty-six Corynebacterium diphtheriae strains from throughout Russia, selected for

253 nd the emergence of epidemic Corynebacterium diphtheriae strains globally have highlighted the need f

254 reservoir for the emergence of toxigenic C. diphtheriae strains if they possessed functional diphthe

255 closely related to each other than to the C. diphtheriae strains isolated in other parts of the Unite

256 atory element (dtxR) from 72 Corynebacterium diphtheriae strains isolated in Russia and Ukraine befor

257 A total of 26 nontoxigenic C. diphtheriae strains isolated in the United Kingdom durin

258 strated that the majority (87.5%; 7/8) of C. diphtheriae strains represented new sequence types (STs)

259 We show that several C. diphtheriae strains use the hemoglobin-haptoglobin (Hb-H

260 PD typing, ribotyping, and PFGE typing of C. diphtheriae strains were improved to enable rapid and co

261 When 23 toxigenic Corynebacterium diphtheriae strains, 9 nontoxigenic C. diphtheriae strai

262 erium diphtheriae strains, 9 nontoxigenic C. diphtheriae strains, and 44 strains representing the div

263 n hemoglobin-iron utilization, whereas in C. diphtheriae strains, deletion of hmuO caused no or only

264 phism [AFLP]) for the characterization of C. diphtheriae strains.

265 eight (40.0%) were caused by Corynebacterium diphtheriae strains; six were biovar mitis, which were a

266 endent regulatory protein in Corynebacterium diphtheriae that controls gene expression by binding to

267 d characterized two novel genetic loci in C. diphtheriae that encode factors that bind hemin and Hb.

268 an extracellular protein of Corynebacterium diphtheriae that inhibits protein synthesis and kills su

269 iron-dependent repressor in Corynebacterium diphtheriae that regulates transcription from multiple p

270 d for the fusion toxin using Corynebacterium diphtheriae that secretes fully folded, biologically act

271 eted by lysogenic strains of Corynebacterium diphtheriae, that causes the disease diphtheria in human

272 y human pathogens, including Corynebacterium diphtheriae, the causative agent of diphtheria, use host

273 Corynebacterium diphtheriae, the causative agent of diphtheria, utilizes

274 Corynebacterium diphtheriae, the causative agent of the severe respirato

275 Intriguingly, in Corynebacterium diphtheriae, the deletion of mdbA blocks cell growth onl

276 Corynebacterium diphtheriae, the etiologic agent of diphtheria, utilizes

277 In Corynebacterium diphtheriae, the pilin-specific sortase SrtA catalyses p

278 livered to the cytoplasm of non-lysogenic C. diphtheriae, they integrated into either the attB1 or at

279 toxin produced by the causative organism, C. diphtheriae; this detection is the definitive test for t

280 chtC gene has no affect on the ability of C. diphtheriae to use hemin or Hb as iron sources; however,

281 nd binary toxin (CDTa-CDTb), Corynebacterium diphtheriae toxin (DT), and Pseudomonas aeruginosa exoto

282 of a heterotrimeric pilus in Corynebacterium diphtheriae, uncovering the molecular switch that termin

283 ia toxin repressor (DtxR) of Corynebacterium diphtheriae uses Fe(2+) as a corepressor.

284 Corynebacterium diphtheriae utilizes hemin and hemoglobin (Hb) as iron s

285 The human pathogen Corynebacterium diphtheriae utilizes hemin and hemoglobin as iron source

286 C. diphtheriae was also able to use human serum albumin (HS

287 Toxigenic C diphtheriae was confirmed for 72 (84%) cases and one ind

288 Corynebacterium diphtheriae was examined for the ability to utilize vari

289 gulatory protein, DtxR, from Corynebacterium diphtheriae was identified from T. pallidum.

290 confirm cases biologically, Corynebacterium diphtheriae was isolated and identified from throat swab

291 ical diphtheritic lesions but from whom no C diphtheriae was isolated from clinical swabs was also in

292 Toxigenic C. diphtheriae was isolated from five members of four house

293 Total cellular RNA isolated from C. diphtheriae was used to identify the transcriptional sta

294 by toxigenic Corynebacterium diphtheriae (C diphtheriae) was reported among asylum seekers arriving

295 prototypical SpaA pilus from Corynebacterium diphtheriae We show that sortase-catalyzed introduction

296 d the systems for genetic manipulation of C. diphtheriae, we constructed plasmid vectors capable of i

297 y toxin-producing strains of Corynebacterium diphtheriae, with similar illness produced occasionally

298 I, 17.7-19.4), and 95% clear Corynebacterium diphtheriae within 48 days (95% CI, 46-51).

299 .7-19.4 days), and 95% clear Corynebacterium diphtheriae within 48 days (95% CrI, 46-51 days).

300 A C. diphtheriae zur mutant was more sensitive to peroxide st