ライフサイエンスコーパス: diploid cell

1 ifferences in expression of two alleles in a diploid cell.

2 isolated cytogenetic finding in an otherwise diploid cell.

3 on of male and female haploid gametes into a diploid cell.

4 from only one of two homologous alleles in a diploid cell.

5 regation yield four haploid gametes from one diploid cell.

6 ts influence expression of both alleles in a diploid cell.

7 in organisms that are primarily comprised of diploid cells.

8 ence of a competing homologous chromosome in diploid cells.

9 er, were reduced in tetraploid compared with diploid cells.

10 DNA ploidy but results in immortalization of diploid cells.

11 /Bud10 in haploid cells and Bud8 and Bud9 in diploid cells.

12 nhances the invasive behavior of haploid and diploid cells.

13 sting it is imported via the same pathway in diploid cells.

14 disadvantage of haploid cells compared with diploid cells.

15 of different mating type combine to produce diploid cells.

16 is a clear determinant of gene expression in diploid cells.

17 mine chromatin organization in polyploid and diploid cells.

18 phase transition of NIH 3T3 and normal human diploid cells.

19 complexes repress haploid-specific genes in diploid cells.

20 tioned adjacent to the a1-alpha2 operator in diploid cells.

21 odifications increased cytotoxicity in human diploid cells.

22 Mmi1 cause high levels of UPD in vegetative diploid cells.

23 id cells and is necessary for sporulation in diploid cells.

24 istant to DNA damage-induced cell death than diploid cells.

25 r inactive X alleles present in normal human diploid cells.

26 in complete remission, all but 2 showed all diploid cells.

27 populations had the allelic loss present in diploid cells.

28 osomal gene is represented by two alleles in diploid cells.

29 on with both normal diploid cells and pseudo-diploid cells.

30 -activation remains difficult, especially in diploid cells.

31 recycling (~ 55% decrease) in comparison to diploid cells.

32 al cancer tumors but is not required in near-diploid cells.

33 ces that chromosomal gains or losses have in diploid cells.

34 ortalized human cell lines as well as normal diploid cells.

35 operate during initiation of instability in diploid cells.

36 he vast majority of oocytes enter meiosis as diploid cells.

37 as affected, as demonstrated in heterozygous diploid cells.

38 e to environmental stresses not tolerated by diploid cells.

39 but does not obviously affect proliferating diploid cells.

40 referentially sensitive to AICAR compared to diploid cells.

41 etween human embryonic stem (hES) and normal diploid cells.

42 e, we examine genetic stability in tel1 mec1 diploid cells.

43 not seen in vegetatively dividing haploid or diploid cells.

44 tation and oxidative respiration relative to diploid cells.

45 uirement for Plk1 than normal nontransformed diploid cells.

46 oses generates CIN in otherwise stable, near-diploid cells.

47 ic imprinted expression in the reconstructed diploid cells.

48 ement, producing haploid gametes/spores from diploid cells.

49 of template DNA, which is equivalent to 1-2 diploid cells.

50 MIP1, to be evaluated in vivo in haploid and diploid cells.

51 The genetic data indicate that in a diploid cell, a heterozygous deletion mutation in the ge

52 In MATa/MATalpha diploid cells, a DSB induced by HO endonuclease was repa

53 -prostate cancer cells, including WI-38 lung diploid cells, A-431 epidermoid carcinoma cells, and HeL

54 Cultures enriched with not-diploid cells acquired a senescence-associated secretory

55 n mating-type gene expression in haploid and diploid cells affect NHEJ function, resulting in distinc

56 hat ethanol stimulates hyperfilamentation in diploid cells, again in a MAPK-dependent manner.

57 bition of Hsp90 with macbecin in sporulating diploid cells also blocked spore formation, underscoring

58 Nonswitching diploid cells also express Ash1, suggesting it could hav

59 WT diploid cells also showed a proliferative advantage, ent

60 cer that occurs ~16,942 times in every human diploid cell and is flanked by nearly random sequences.

61 clear homodimers in contact inhibited normal diploid cells and dimerization of p12 is a necessary pro

62 Both suppressor genes are dominant in diploid cells and lethal in haploid cells.

63 d poliovirus vaccine (IPV) produced in human diploid cells and live attenuated oral poliovirus vaccin

64 This system uses diploid cells and provides the possibility for allelic r

65 the sampled cell population with both normal diploid cells and pseudo-diploid cells.

66 deletions of one copy of essential genes in diploid cells and purified spores containing the deletio

67 gnificant correlations between levels of not-diploid cells and senescence-associated features (SAFs).

68 ersions of the G subunit were expressed in a diploid cell, and affinity purification of cytosolic V1

69 on morphology, bipolar bud site selection in diploid cells, and cell separation.

70 ng force in the evolution of mitotic/somatic diploid cells, and cellular changes that increase the ra

71 YAR1 is transcribed in both haploid and diploid cells, and in haploid cells arrested in G1 with

72 cterized using a large dataset of 129 normal diploid cells, and is shown to exceed previously reporte

73 that the replication profiles of haploid and diploid cells are indistinguishable, indicating that bot

74 ly stall at such barriers in late S phase of diploid cells are left unresolved in the shortened S pha

75 The proportion of diploid cells, as determined by flow cytometry, varied f

76 null-targeting method can be applied to any diploid cell, at any locus for which a negative selectio

77 CDKN2 mutations develop as early lesions in diploid cells before aneuploidy and cancer during neopla

78 haploid cells bud in an axial manner, while diploid cells bud in a bipolar manner.

79 In diploid cells, but not in chromosomally unstable cells,

80 ia, however, FLO11 transcripts accumulate in diploid cells, but not in haploids.

81 ies display growth advantages over wild-type diploid cells, but the mechanisms that yield a drift fro

82 Growth arrest of normal diploid cells by contact inhibition resulted in an induc

83 Although diploid cells can switch seamlessly between pyrimidine s

84 In contrast, diploid cells cannot mate because genes that encode comp

85 of both RST1 and RST2 (rst-) causes a/alpha diploid cells constitutively to express a-specific genes

86 g endogenous human chromosomes to regenerate diploid cells containing a transferred chromosome.

87 active new system to address how postmitotic diploid cells contribute to repair.

88 we propose that Ume6 serves a unique role in diploid cells, coupling metabolic responses to nutrition

89 ccination (2 doses of 0.1 mL ID of the human diploid cell culture rabies vaccine [HDCV] at days 0 and

90 demonstrates that the loss of FoxM1 elicits diploid cell deficiency with enhanced arrests prior to m

91 ortex; in particular, the bipolar budding of diploid cells depends on persistent landmarks at the bir

92 To study the phenotype of C. albicans diploid cells depleted of CaCse4p, we deleted one copy o

93 We show here that normal diploid cells derived from AT patients do not exhibit co

94 Diploid cells divide at a larger size than haploid cells

95 ng regulation occurs during meiosis in which diploid cells divide to form haploid gametes.

96 but its function is not required for normal diploid cell division.

97 Colonies initiated with aged diploid cells do not show disadvantage in colony expansi

98 of accurately genotyping DNA from one single diploid cell equivalent.

99 A replication and promoting proliferation in diploid cells, even when developmental signals normally

100 xhibit an axial budding pattern, and a/alpha diploid cells exhibit a bipolar pattern.

101 it an axial budding pattern, whereas a/alpha diploid cells exhibit a bipolar pattern.

102 arasexual cycle as tetraploid cells, but not diploid cells, exhibit genome instability and reduce the

103 midway through meiosis, and homozygous ssp1 diploid cells fail to sporulate.

104 In diploid cells, FANCJ is believed to operate in homologou

105 neage undergo mitotic proliferation to yield diploid cells, followed by endomitosis and acquisition o

106 of filamentous growth was also observed for diploid cells following MEK/ERK expression in liquid cul

107 ynamics observed in vivo in both haploid and diploid cells follows a process of dissociation-aggregat

108 velopmental switch: when FLO11 is expressed, diploid cells form pseudohyphal filaments; when FLO11 is

109 losses were also found in the corresponding diploid cells from premalignant epithelium in all three

110 fungal pathogen Candida albicans, mating of diploid cells generates tetraploid products that return

111 In eukaryotes, diploid cells give rise to haploid cells via meiosis, a

112 siae is a highly regulated process wherein a diploid cell gives rise to four haploid gametes.

113 Meiosis is the cellular program by which a diploid cell gives rise to haploid gametes for sexual re

114 tion of interphase is similar in haploid and diploid cells, haploid cells spend longer in mitosis, in

115 Subpopulations sorted to contain diploid cells harbored up to ~40-fold more FQ persisters

116 tract-length changes are half as frequent in diploid cells harboring heterozygous HRAS1 minisatellite

117 Normal diploid cells have a limited replicative potential in cu

118 We show that normal diploid cells have a more robust error-correction machin

119 We show here that cultured normal human diploid cells have longer G overhangs at telomeres gener

120 Most normal human diploid cells have no detectable telomerase; however, ex

121 In wild-type diploid cells, heteroallelic recombination between his4A

122 cells: (i) normal telomerase-negative human diploid cells; (ii) normal cells transfected with the hu

123 acking of the two copies of the GAL locus in diploid cells in both activating and repressive conditio

124 egulated in meiosis-competent MATa/MAT alpha diploid cells in comparison with diploids or haploids ex

125 Moreover, we show that diploid cells in mosaic embryos undertake compensatory p

126 no drug-resistant mutants were obtained from diploid cells in our conditions.

127 yeast Saccharomyces cerevisiae is induced in diploid cells in response to nitrogen starvation and abu

128 romatin we have established 'isogenic' human diploid cells in which PARP1 and/or PARP2, or PARP3 are

129 o developed a protocol for null targeting of diploid cells, in which transfection of a DHFR-TS deleti

130 segregation compromises the proliferation of diploid cells, indicating that phenotypic changes that p

131 ed in G(1), S, and M phases and from meiotic diploid cells, indicating that they are constitutive com

132 a significant increase in the proportion of diploid cells, indicative of cell cycle arrest in G0-G1,

133 In Arabidopsis thaliana, a single diploid cell is specified as the premeiotic female gamet

134 nclear because the proliferation of cultured diploid cells is compromised by chromosome missegregatio

135 However, conditional gene inactivation in diploid cells is still difficult to achieve.

136 Both haploid and diploid cells lacking Akr1p grow slowly and develop defo

137 Loss of Nm23-H1 in diploid cells leads to cytokinetic furrow regression, fo

138 ell lines and compared to those on a healthy diploid cell line for cellular cytotoxicity.

139 Accordingly, we generated a diploid cell line from divergent parents and applied hap

140 ree" saturation genome editing approach in a diploid cell line to simultaneously score 2,542 variants

141 to FFPE processing, a robustly characterized diploid cell line was used to create FFPE samples with f

142 Transfection of this stably diploid cell line with genomic DNA fragments from a huma

143 xisting Dryvax vaccine for growth in a human diploid cell line.

144 ctation for elements ascertained in a single diploid cell line.

145 traploid isogenic cells that had arisen from diploid cell lines displayed lower drug sensitivity than

146 nd apoptosis in cancer cells, whereas normal diploid cell lines, hTERT-RPE1 and MCF10A, survived a si

147 bsence of RAD52, repair is nearly absent and diploid cells lose the broken chromosome; however, in ce

148 tumors, but the mechanisms by which a stable diploid cell loses the ability to maintain genomic integ

149 In normal diploid cells, malattachments arise spontaneously and ar

150 p53 inactivation and c-myc overexpression in diploid cells markedly accelerates the spontaneous devel

151 educe the states of chromatin folding in the diploid cell nucleus.

152 ring phenotypes of recessive genes in normal diploid cells of about 10(-12).

153 Diploid cells of budding yeast produce haploid cells thr

154 Diploid cells of Chlamydomonas reinhardtii that are hete

155 he conservation of TADs between polytene and diploid cells of Drosophila.

156 Finally, we find that diploid cells of equivalent size to haploid cells exhibi

157 resses this subject for vegetatively growing diploid cells of fission yeast Schizosaccharomyces pombe

158 In the diploid cells of most organisms, including humans, each

159 e ratio of normal to aneuploid nuclei in the diploid cells of patients with impaired spermatogenesis

160 In response to starvation, diploid cells of Saccharomyces cerevisiae undergo meiosi

161 In wild-type diploid cells of Saccharomyces cerevisiae, an HO endonuc

162 is approach to evolve genetic instability in diploid cells of the budding yeast Saccharomyces cerevis

163 Diploid cells of the budding yeast Saccharomyces cerevis

164 In response to nitrogen starvation, diploid cells of the budding yeast Saccharomyces cerevis

165 Starvation of diploid cells of the budding yeast Saccharomyces cerevis

166 consequences of removing one copy of MAD2 in diploid cells of the budding yeast, Saccharomyces cerevi

167 salivary gland but not in the predominantly diploid cells of the embryo or larval imaginal discs and

168 In response to nitrogen starvation, diploid cells of the yeast Saccharomyces cerevisiae diff

169 Nitrogen-starved diploid cells of the yeast Saccharomyces cerevisiae diff

170 Diploid cells of the yeast Saccharomyces cerevisiae form

171 In response to nitrogen limitation, diploid cells of the yeast Saccharomyces cerevisiae unde

172 ion in the presence of a poor carbon source, diploid cells of the yeast Saccharomyces cerevisiae unde

173 In diploid cells of the yeast Saccharomyces cerevisiae, the

174 se regulatory pathways that also function in diploid cells, particularly those involved in S phase en

175 rol, nitrogen starvation, or sporulation (in diploid cells) pathways.

176 e regulation of genes specific to haploid or diploid cells plays a key role in determining which path

177 p53-mutant clones, including diploid cell populations, underwent expansion from 1 to

178 chanisms are likely to synergize to maintain diploid cell populations.

179 tify a population of proliferating Blimp1(+) diploid cells present within the spongiotrophoblast laye

180 Diploid cell progenitors with somatic genetic or epigene

181 These results suggest that in normal diploid cells, Ras proteins regulate oxidant production

182 Direct knockdown of H19 expression in diploid cells resulted in acquisition of polyploid cell

183 xpression of the H3.3 K27M mutant in normal, diploid cells results in increased chromosome missegrega

184 Normal human diploid cells senesce in vitro and in vivo after a limit

185 In diploid cells, sir mutants showed a twofold reduction in

186 In its absence diploid cells skip meiosis I and execute meiosis II divi

187 Finally, we report that diploid cells starved for glucose also initiate the fila

188 hat the poliovaccine was passaged in a human diploid cell strain.

189 Overexpression of cyclin D2 in diploid cells strongly potentiated the ability to prolif

190 of G1 to S phase transition in normal human diploid cells such as WI38, suggesting that the genetic

191 ice was able to yield HCCs composed of small diploid cells, suggesting that initiated cells are gener

192 d version of the E subunit from heterozygous diploid cells, suggesting that more than one E subunit i

193 i5 activator protein is not bound to URS1 in diploid cells, suggesting that recruitment of the Tup1-C

194 e give rise to teliospores, which are round, diploid cells surrounded by a specialized cell wall.

195 acts were more stable in the mitochondria of diploid cells than in haploids.

196 lves the fusion of haploid gametes to form a diploid cell that subsequently undergoes meiosis to gene

197 otype will surpass the viability of a normal diploid cell, the evolution of a neoplastic cell species

198 In diploid cells, the a1-alpha2 complex represses the trans

199 overcome inhibition of SAC more readily than diploid cells, their long-term proliferation was jeopard

200 However, compared to its diploid cells, these haploid C. tropicalis cells grow mo

201 Similar to its diploid cells, these newly discovered C. tropicalis hapl

202 ng the proliferation and senescence of human diploid cells through a ROS signaling pathway.

203 defects in late anaphase and cytokinesis in diploid cells; thus one hypothesis is that the expressio

204 esponse, promoting the transition of the new diploid cell to vegetative growth.

205 RC) protein Cdc6 causes human nontransformed diploid cells to arrest nonlethally in G1-G1/S and S pha

206 ivision that halves the genetic component of diploid cells to form gametes or spores.

207 essential because they are better able than diploid cells to mechanically stabilize wounds, especial

208 uploid cancer cells were less sensitive than diploid cells to short-term exposure to multiple SAC inh

209 Thus, CIN cells may respond differently than diploid cells to treatments that target mitotic spindle

210 Normal human diploid cells transiently expressing hTRT possessed telo

211 whole-genome doubling (WGD) event, in which diploid cells transition to a tetraploid state.

212 Rst1 and Rst2 are necessary for the a/alpha diploid cell type.

213 there are similarities between haploids and diploids, cell type-specific differences clearly alter t

214 thout perturbing cell proliferation in other diploid cell types.

215 iable haploid state that can be derived from diploid cells under in vitro and in vivo conditions, and

216 oublings (PDs), cultures of normal mammalian diploid cells undergo an irreversible growth arrest know

217 During meiosis, a diploid cell undergoes two rounds of nuclear division fo

218 -labeled cells showed that the percentage of diploid cells undergoing DNA synthesis, the progression

219 yces pombe mei3(+) gene is expressed only in diploid cells undergoing meiosis.

220 G1 and G2 phases in tumor as well as normal diploid cells using automated particle tracking.

221 virus standard rabies virus, or with a human diploid cell vaccine (HDCV).

222 o cell vaccine (PVRV; Verorab) and the human diploid cell vaccine (HDCV; Imovax Rabies(R)).

223 paired in vegetatively growing budding yeast diploid cells, via multiple interstitial interactions, a

224 directs bud emergence to the distal pole of diploid cells, was localized to the distal pole of haplo

225 hat proteins required for bipolar budding in diploid cells were required for haploid invasive growth.

226 ociation with pericentric heterochromatin in diploid cells, where it appears to have roles in chromos

227 Overexpression of FLO11 in diploid cells, which are otherwise not invasive, enables

228 In heterozygous diploid cells, wild-type Pol-gamma suppresses mutation-a

229 sizes in different model systems, including diploid cells with a chromosomal breakpoint that has bee

230 Diploid cells with a single copy of NDC1 can survive by

231 n with the homologous chromosome, whereas in diploid cells with an alpha mating type (matDelta/MATalp

232 near-tetraploid, we transiently transfected diploid cells with siRNA against ESPL1/Separase, a prote

233 pression of polo-like kinase 2, resulting in diploid cells with two centrosomes in G1-arrested cells.

234 in plasticity both within and between single diploid cells, with chromatin actuation diverging by 61%