ライフサイエンスコーパス: direct

1 Direct-acting agents, targeting protease and polymerase

2 pid changes in metabolic parameters early in direct-acting antiviral (DAA) therapy.

3 ation of addiction, related to impaired goal-directed actions, as well as countervailing resilience s

4 er segmented negative-sense RNA viruses, may direct activities such as virus assembly and innate immu

5 PFQX in conjunction with ligand-directed acyl imidazole chemistry enables covalent label

6 nduced less changes to wine composition than direct addition of GSP to the wine.

7 ions, redosing or combination of CAR T cells directed against different targets, and decreased cost u

8 potential for new therapeutic interventions, directed against evolving resistance.

9 the receptor-binding domain (RBD) and those directed against the N-terminal domain (NTD), indicating

10 es in the NOD mouse model of T1D produce Abs directed against the neuronal type III intermediate fila

11 oantibodies in serum and cerebrospinal fluid directed against the nuclei of Purkinje cells, striatal

12 dies was about equally divided between those directed against the receptor-binding domain (RBD) and t

13 d a new strategy using proteins as structure-directed agents to direct the formation of new ZMOFs tha

14 te tumor DDR function and sensitivity to DDR-directed agents, we created a series of ATM-deficient pr

15 The direct alpha-arylation of carbonyl compounds emerged ove

16 ssion events associated with Chr1- and Chr10-directed AMD.

17 o rapidly preconcentrate PFOA from water for direct analysis by nanoelectrospray ionization mass spec

18 An enclosed interface that joins a direct analysis in real time (DART) probe, solid-phase m

19 on derivatization of SCFAs with paper-loaded direct analysis in real time mass spectrometry (pDART-MS

20 nduced breakdown spectroscopy (LIBS) for the direct analysis of liquid food products.

21 Aside from the direct anatomic link between PVN and RAIC, our findings

22 her H. heidelbergensis/H. rhodesiensis was a direct ancestor of our species(13,14).

23 Direct and continuous monitoring of propofol is crucial

24 ay to explore purely chemical tools that can direct and control cellular behavior.

25 infection has been associated with multiple direct and indirect cardiovascular complications includi

26 lations and communities through a variety of direct and indirect ecological pathways.

27 However, little is known of direct and indirect fungal interactions with Se-/Te-bear

28 Moreover, direct and indirect pathways also play distinct roles in

29 A direct and selective aromatic nitration reaction may be

30 distinction is made between voluntary (goal-directed) and involuntary (stimulus-driven) guidance of

31 egrated into photonic structures to amplify, direct, and tune their emission or as hosts for isolated

32 n the carbon fluxes of these ecosystems, the direct anthropogenic disturbance may play a greater role

33 to regulate lung inflammation but it has no direct antiviral activity against ECTV.

34 by the ePlex RPP, NxTAG RPP, and Mycoplasma Direct assays, respectively.

35 The technique also allows the direct assessment of the efficiency of protective layers

36 BRD4 direct association to chromatin regulatory regions of th

37 Through direct association with pol II or by modulating the acti

38 ese are organic in nature, including some of direct astrobiological interest.

39 cient Pd/enamine catalytic procedure for the direct asymmetric alpha-allylation of branched aldehydes

40 E, esIgD, esIgG(1) , and esIgG(4) antibodies directed at 58 (15-mer) overlapping peptides, covering t

41 unmet need to develop mechanistic treatments directed at root causes of AF.

42 promoted USV(+) mounting, and converted male-directed attack to mounting with USVs.

43 nanobodies for the target protein allows the direct attainment of structural information on the wild-

44 TnI-directed autoimmune myocarditis (TnI-AM), a CD4(+) T-cel

45 DP solid solutions that span the indirect to direct band-gap modification which exhibit tailorable op

46 sorption onsets in the near infra-red with a direct bandgap value of 1.46 eV, suitable for single jun

47 Goal-directed behavior requires the interaction of multiple b

48 We first demonstrate that learning via goal-directed behaviour indeed constrains models to behaviora

49 HITS-CLIP) and biochemical analyses revealed direct binding between endogenous TruB1 and the stem-loo

50 romoter switch during CD4SP development, via direct binding to the Satb1 P2 promoter.

51 Direct bladder instillation of antibiotics has proved di

52 ith retained affinity for VRC01-class, CD4bs-directed bNAbs and dampened affinity for nonneutralizing

53 We then achieved direct bonding between two Au [Formula: see text] surfac

54 electromagnetic field tensors obtained by a direct boost [Formula: see text] and successive boosts [

55 tems (two Pd-based and one Ni-based) for the direct borylation of aryl (pseudo)halides using tetrahyd

56 le of catalytic 1,2-diarylation of an alkene directed by a native carboxylate group.

57 Embryogenesis is directed by morphogens that induce differentiation withi

58 ges indicate that the branching patterns are directed by the seed defects, with the emergence of bran

59 The applicability of this direct C-O bond formation method is shown by synthesizin

60 In this review, direct catalytic reductive aldol and Mannich reactions a

61 elated to the breakdown of the last relevant directed catalytic cycle within a dynamical system.

62 Manipulating these parameters directed cells in mathematically predictable ways; speci

63 Here, we reevaluated this paradigm by a direct cellular analysis, demonstrating that IgE product

64 ies, many patients may not receive guideline-directed cephalosporin-based prophylaxis, which may resu

65 ar > early successional >= restored prairie; direct climate benefits ranged from ~80% (stover) to 290

66 into the host immunologic response, and has direct clinical implications for the management and foll

67 OpenSim Moco uses the direct collocation method, which is often faster and can

68 Moco is the first musculoskeletal direct collocation tool to handle kinematic constraints,

69 rate fidelity of our mrdna framework through direct comparison of the simulation results with the res

70 Single-cell RNA sequencing and direct comparison to fetal specimens suggest that the sk

71 ette-Guerin (BCG) were used as stimuli, with direct comparison to QFT.

72 ale into a continuous scale and permitting a direct comparison with the continuous DeltaSUV(max) scal

73 Direct competition between tumor-infiltrating lymphocyte

74 chanisms of RNA stabilization that depend on direct competition for binding sites among protective RN

75 icromagnetic immunoconjugates to establish a direct competitive assay between the m6A target and a bi

76 -driven habitat transformation rather than a direct consequence of climate.

77 cluding strains with epidemic potential as a direct consequence of genetic exchange mechanisms such a

78 f infected individuals, and spread either by direct contact or by ingesting contaminated food or wate

79 This direct conversion to memory is associated with a selecti

80 ve effect at the Schottky junction under the direct current modifies the space-charge distribution in

81 The classic theory of direct-current (DC) insulator-based dielectrophoresis (i

82 ons is largely bypassed, consistent with the direct deacetylation hypothesis.

83 Either genetically directed deletion or acute optogenetic silencing of DR(S

84 cell membrane fusion, a recent strategy for direct delivery of proteins into the cell cytoplasm.

85 ules and demonstrate that an in situ-induced direct desulfurization reaction of the thiophene moiety

86 humans, we measured both the "survival" and direct detectability of iridescent and non-iridescent be

87 ng widely varying GC-bias, and demonstrating direct detection of epigenetic modifications.

88 dients in thin films (DGT) technique for the direct determination of aqueous mercury(II).

89 the analytical method is demonstrated by the direct determination of model basic drugs (nortriptyline

90 Here, we report the directed differentiation of human iPSCs into airway basa

91 Direct DNA repair gene GAs were identified in 109 patien

92 all interfering RNAs (siRNAs) that guide RNA-directed DNA methylation.

93 ost-FMT patients to colonize GF mice shows a direct effect of fecal microbiota independent of active

94 Indian Summer Monsoon (ISM) rainfall has a direct effect on the livelihoods of two billion people i

95 pogenic drivers differ, accounting for their direct effects and effects mediated through other driver

96 Direct effects are plausible because KLOTHO is expressed

97 supply chains will magnify losses beyond the direct effects of COVID-19.

98 were formed as a result of the indirect and direct effects of ionizing radiation, among other DNA da

99 model to estimate their total, indirect, and direct effects on IQ.

100 the gut microbiota to the brain and discuss direct effects that gut bacterial molecules are likely e

101 ssions were significant but smaller than the direct effects, during the 14-y model simulation period.

102 e, a TCA cycle intermediate that serves as a direct electron donor to mitochondrial complex II.

103 e areas include i) being the first to report direct electron transfer of oxidoreductase enzymes enabl

104 indirect effects of fire, in addition to the direct emissions, is an overlooked mechanism for explain

105 led assembly of triple-helical domains or by direct engagement of the C-Pro itself.

106 Direct engagement with providers using academic detailin

107 of sample-transfer steps and facilitate the direct enzymatic digestion of extracted RNA within the s

108 matin quantitative trait loci, elucidated by direct epigenetic profiling of specific human tissues, m

109 analytes improved up to 19-fold compared to direct ESI-MS of single-phase droplets (aqueous plugs se

110 To obtain direct evidence for the presence of these uracils, we en

111 However, direct evidence for the spontaneous formation of OR dime

112 terrestrial, and omnivorous animal provides direct evidence of the deep history of directional behav

113 profiling with genetic screening, we provide direct evidence that oncogene-induced loss of progenitor

114 The data provide direct evidence that self-replication through secondary

115 etic approaches in mice to provide the first direct evidence that the nectin-afadin axis is essential

116 A and IAV vRNA in infected cells and provide direct evidence that vRNA-associated Rab11A have altered

117 lls for almost two decades despite a lack of direct evidence.

118 ET94 (PpDyP) and three variants generated by directed evolution (DE) are studied aiming at the design

119 Directed evolution of a serine-ligated P450 variant, P41

120 spect that is often overlooked in laboratory directed evolution studies.

121 Using directed evolution, we engineered a 'decoy-resistant' IL

122 fast-spiking inhibitory interneurons receive direct excitatory input from the intermediate/ventral hi

123 tion, presumably because RTN, unlike C1, has direct excitatory projections to abdominal premotor neur

124 However, the direct experimental observation and transformation kinet

125 cipants showed reduced levels of uncertainty-directed exploration and increased levels of random expl

126 Modeling revealed attenuated directed exploration under L-dopa, while neural signatur

127 with NLPHL who had received Hodgkin lymphoma-directed first-line treatment in randomized GHSG trial p

128 Although the neural circuits underlying more direct forms of learning have been well established over

129 is framework guides mechanistic inference by directing functional validation studies to the most rele

130 a to highlight future research questions and direct future clinical trials.

131 ting at super-enhancer regulatory regions to direct gene expression.

132 ChIP identified Stat6 as a direct gene target of c-Myc in ILC2.

133 Cambrian by autotetraploidization (that is, direct genome doubling).

134 our widely-applicable approach for inferring directed genotype networks from data, but also provide a

135 emoglobin A1c) levels, which poorly reflects direct glucose variation.

136 the use of weakly coordinating amide as the directing group, as previous studies have shown that Hec

137 pivaloyl group acts as a weakly coordinating directing group.

138 iral mediator, we have developed a transient-directing-group approach to reductive Heck hydroarylatio

139 ays are preferred when stronger-coordinating directing groups are used with maleimide coupling partne

140 naling modulates the cytoskeleton to produce directed growth cone motility.

141 6-hexakis (trifluoromethyl)- cyclohexanes by direct hydrogenation of precursor tetrakis- or hexakis-

142 (EpiSC) by specific ligands might enable the direct imaging of EpiSCs after MI to better understand t

143 This can complement existing T cell-directed immunotherapy, providing a promising approach t

144 sphorylated state, and one that could have a direct impact on cognitive function.

145 ndrome-related coronavirus 2 infection has a direct impact on the clinical outcomes of coronavirus di

146 tial and temporal changes in land cover have direct impacts on the hydrological cycle and stream qual

147 Nuclear war, beyond its devastating direct impacts, is expected to cause global climatic per

148 ta fibril formation, with insights that have direct implications for deducing the molecular progressi

149 fectiveness of this approach, as well as the direct implications in clinical management, should be fu

150 sformation has been demonstrated through the direct incorporation of trifluoromethyl into aromatic an

151 products, buildings, and infrastructures has directed increasing attention to urban mining and circul

152 st (CP55940) on the balanced activity of the direct/indirect pathways in the SNr and its associated b

153 We show that stimulus-driven and goal-directed influences compete for selection in memory, and

154 ) fluid from patients with EVALI can provide direct information on exposure within the lung.

155 Direct-infusion ESI-MS showed that the tested volatile e

156 lture, progesterone was determined to have a direct inhibitory effect on C. burnetii replication.

157 opy (FLIM) is a key technology that provides direct insight into cell metabolism, cell dynamics and p

158 The direct-instillation nasal allergen challenge (NAC) and t

159 Lastly, we show a direct interaction between Med19 and Med1 by GST pulldow

160 fied TOLLIP as a stabilizer of STING through direct interaction to prevent its degradation.

161 -regulate each other, they also cooperate by direct interaction with each during early oocyte develop

162 targeted to microvilli in the absence of any direct interaction with the other IMAC components.

163 Further, we tested direct interactions between inner and outer photorecepto

164 virus against the exogenous form, either via direct interference or indirectly via gene regulation, a

165 Parallel experiments with direct intracranial virus infection generated similar re

166 rganisation and conscious cognition requires direct investigations into neuropsychologically-relevant

167 ing, with embodied theories supporting their direct involvement in processing verbs describing body p

168 In summary, the Simplexa Bordetella Direct kit has a performance comparable to those of othe

169 the risk of complications when compared with direct laryngoscopy.

170 ive reaction of graphene, thereby completing direct laser writing on graphene toward a spatially reso

171 olo[3,2-c][1,3,5,2]oxadiazaborinine dyes via direct lithiation of the 1,3-thiazole ring was developed

172 re probing using chemical modifications with direct long-read RNA sequencing and machine learning to

173 contrast to the LRR-directed mAbs, the EPTP-directed mAbs showed far less avid binding to brain tiss

174 campal injection, and by contrast to the LRR-directed mAbs, the EPTP-directed mAbs showed far less av

175 trating tire-integrated system that combines direct mask-less 3D printed strain gauges, flexible piez

176 a master modulator of merozoite invasion and direct maturation of proteins required for invasion, par

177 the best of our knowledge, this is the first direct measurement of glucose flux through the HBP in an

178 imize nonideal mixture behavior, and (4) the direct measurement of pressure inside the saturator to a

179 Rarity and phylogenetic rarity - direct measures of the number of species or the portion

180 These data provide direct mechanisms by which an MHC-II SE contributes to e

181 tive of the healthcare provider, the average direct medical cost per case was US $58.64 (range: US $3

182 3.6-54.1 million cases, $4.0-$6.5 billion in direct medical costs, and $44.8-$64.7 billion in product

183 th UMI were less likely to receive guideline-directed medical therapies and presented an increased ri

184 ir (TMVr) using the MitraClip plus guideline-directed medical therapy (GDMT) reduced 2-year rates of

185 nes, ring opening of 2-imino-2H-azirines, or direct metalation of 4-azadiene-1-amine derivatives.

186 enient method seems to be derivatization via direct metalation, but synthesis of polysubstituted thio

187 ss, has been proposed as a mechanism driving directed migration.

188 and are unable to effectively differentiate direct miRNA targets from downstream regulatory changes.

189 hydrogen (S(N)(H)) was first applied for the direct modification of nonaromatic 2H-imidazoles to affo

190 ation-controlled electronics and established direct modulation mechanism by external mechanical stimu

191 etic strategies, which directly provides the direct molecular-based design of functionalized polymer/

192 e expression, but the mechanisms behind this directed movement have remained uncertain.

193 electron microscopy, corrosion casting, and direct multiplexed measurement of gene expression.

194 2 intermediates and iterative rounds of site-directed mutagenesis allowed us to identify 4 of 413 res

195 Kinetic, molecular docking, and site-directed mutagenesis analyses confirmed these compounds

196 Results from site-directed mutagenesis and competitive ligand-binding anal

197 reinhardtii (CrHydA1) we have conducted site-directed mutagenesis and protein film electrochemistry t

198 We used site-directed mutagenesis and single-cell patch-clamp to anal

199 hippocampus, together with an in vitro site-directed mutagenesis approach, we identify loss of STAT3

200 Site-directed mutagenesis of both cofilin and actin revealed

201 ture and function of CHT7, we performed site-directed mutagenesis of previously identified phosphoryl

202 type fructooligosaccharide and utilized site-directed mutagenesis to identify residues involved in su

203 used the chemical modification of Trp9, site-directed mutagenesis, and crystallographic and computati

204 Using site-directed mutagenesis, surface plasmon resonance, and cry

205 e determinants were resolved further by site-directed mutagenesis.

206 in E coli supports efficient multiplex site-directed mutagenesis.

207 Direct myosin inhibition could provide optimal muscle re

208 We obtained direct neural recordings from electrodes implanted in hu

209 companies have recently initiated testing of direct NLRP3 inhibitors in the clinic.

210 base-promoted catalytic mechanism, invoking direct nucleophilic attack by the substrate alpha-amino

211 0 mixture of cis and trans isomers and (2) a direct nucleophilic substitution leading to a stereosele

212 Live cell imaging allows direct observation and monitoring of phenotypes that are

213 probe microscopy on surface enable not only direct observation of molecular structures but also loca

214 Enormous internal turgor pressure is directed onto a penetration peg emerging from the unmela

215 specific enzymes associated with diseases by direct optimization using single purified enzymes.

216 Podocytopathies are kidney diseases in which direct or indirect podocyte injury drives proteinuria or

217 gen conditions, NHC-iridium(I) catalyzed the direct or one-pot sequential synthesis of alpha,alpha-di

218 he safety and effectiveness of dual therapy (direct oral anticoagulant [DOAC] plus P2Y12 inhibitor) v

219 Direct oral anticoagulants are noninferior to warfarin w

220 The introduction of 4 direct oral anticoagulants beginning in 2010 has signifi

221 Direct orbital overlap results in strongly coupled, larg

222 or both CD4(+) and CD8(+) T cells and of the direct orchestration of their cross-talk that is require

223 Phosphonate-directed ortho C-H borylation of aromatic phosphonates i

224 One of the direct outcomes on the first synthesis of a complete set

225 hese radical intermediates are formed by the direct oxidation of a B-B bond between a boron cluster c

226 A direct path to exploit it is the generation of heat, for

227 mainly decreased the inhibitory, potentially direct pathway component while sparing the excitatory, p

228 oss attention task conditions, we found that direct-pathway activation caused changes in performance

229 Gap junctions establish direct pathways for cells to transfer metabolic and elec

230 TFFs are not readily "druggable" in a direct pharmacologic manner and thus have proven difficu

231 driven by local membrane protrusion through directed polymerization of F-actin at the front.

232 Local adaptation directs populations towards environment-specific fitness

233 -component Co(-I) complex is proposed as the direct pre-catalyst.

234 ement of auxin transport in protoplasts, and direct quantification of free auxin levels suggest these

235 gradual precessional pacing, suggesting that direct rainfall forcing effects were predominantly drive

236 n-sequencing-based analyses demonstrate that direct readout of H3K27me3 by BAHCC1 is achieved through

237 the early visual cortex despite the lack of direct receptive field activation.

238 dCas9 mediated enhancer blocking establish a direct regulatory link between this enhancer and lncRNAs

239 h LAC2-dependent lignification, suggesting a direct relationship between these processes.

240 captures the dynamic behaviour of E2 and has direct relevance to the interaction of HCV with cell-sur

241 ange of transition-metal-catalyzed, template-directed remote C-H activation reactions of alcohols, ca

242 es (tCTSs) added at the ends of the homology-directed repair (HDR) template interact with Cas9 ribonu

243 as temperature-dependent stress relaxation, direct reprocessing and recycling abilities of a range o

244 Furthermore, direct restoration of the astrocyte lactate supply alone

245 se 2 DNA-protein crosslinks (TOP2-DPCs) in a direct-reversal pathway licensed by ZATTZNF451 SUMO2 E3

246 ses confirmed these compounds as active site-directed reversible inhibitors of mPTPB.

247 rned that grade and lymph_nodes_positive are direct risk factors for 5 year metastasis.

248 her GES nor NPC learned that HER2 and ER are direct risk factors.

249 Here, we performed Direct RNA Sequencing (DRS) using the latest Oxford Nano

250 We applied nanopore-based direct RNA sequencing to characterize the developmental

251 Silencing expression of RNA-directed RNA polymerases RdR1 and RdR2 (but not RdR3) an

252 RNA could be detected from NP samples via a direct RT-qPCR assay that omits the RNA extraction step

253 One of the direct SARRAH targets is NRF2, and restoration of NRF2 l

254 Neighbour-joining phylogenetic trees and direct sequence comparison were used to detect the prese

255 Site-directed spin labeling (SDSL) ESR is a valuable tool to

256 on and metastatic growth by repressing MBNL1-directed splicing of ITGA6 Our findings also indicate th

257 ed before reporting through correlation with direct staining (Gram and calcofluor white) and CSF cryp

258 When exposed to direct sunlight, the upgraded coating over an aluminum p

259 ic materials permit subambient cooling under direct sunshine, and their applications are expanding ra

260 bly, Kruppel-like factor 4 was found to be a direct target of miR-128 and able to modulate the methyl

261 rienced strong selection in fonio, providing direct targets to rapidly improve this crop for agricult

262 n signaling with SMAD3 and SMAD4 shown to be direct targets.

263 piRNA biogenesis but is essential for piRNA-directed TE de novo methylation and silencing.

264 tic tools for choanoflagellates has hampered direct tests of gene function and impeded the establishm

265 ing proteins as structure-directed agents to direct the formation of new ZMOFs that can act as versat

266 Despite advances in directing the assembly of biomacromolecules into well-de

267 ent literature on the role of the support on directing the nanostructures of Au-based monometallic an

268 noproline (Amp) and aspartic acid (Asp) that directs the composition and register-specific assembly o

269 s, we discovered that the tetrahedral linker directs the formation of new RE-MOFs, RE-ken-MOF-1 (RE:

270 ly, and facilitate development of microbiota-directed therapeutics.

271 Anti-interleukin-6-directed therapies are highly effective in many iMCD pat

272 d with local cytoreductive and/or metastasis-directed therapies.

273 support targeting S100A8/A9 pathways as host-directed therapy for TB.

274 valuation of pravastatin as adjunctive, host-directed therapy for TB.

275 cytoreductive strategy, including metastasis-directed therapy, in the current era of sequential multi

276 and major bleeding within 72 hours after BEC directed therapy.

277 osis and potentially enabling prompt disease-directed therapy.

278 tes MYC at serine 67, counteracting GSK3beta-directed threonine 58 phosphorylation and subsequent FBX

279 syndrome, or multiple organ dysfunction; and direct tissue injury (n = 64, 21.9%) including brain and

280 ports in the infected provinces in China and directed to Africa to estimate the risk of importation p

281 and Shuker introduce animal sexual behaviors directed to members of the same sex.

282 We report here that ANKS4B is directed to the brush border using a noncanonical apical

283 ion criterion selectively when attention was directed to the contralateral visual field.

284 databases and pave the way for clinical and direct-to-consumer (DTC) applications.

285 , in recent years research efforts have been directed towards modeling the structure and dynamics of

286 Pharmacologic and probiotic approaches directed towards specific TLR2 signaling processes might

287 cally plausible, and increasing attention is directed towards thrombotic microembolism as the underly

288 Whereas direct toxicity exerted by APAP metabolites is a key det

289 s cell and tissue growth by functioning as a direct transcriptional repressor of the master regulator

290 cogenic ERG repressed PI3K signaling through direct transcriptional suppression of IRS2, leading to r

291 Finally, we showed that ALDH1A1 is a direct transcriptional target of SOX9, based on chromati

292 ate that surpasses the ideal loss-equivalent direct-transmission method while operating at megahertz

293 esults of positron emission tomography (PET)-directed treatment approaches, we designed a National Cl

294 diting of LAYN in human CD8+ T cells reduced direct tumor cell killing ex vivo.

295 d theoretical investigation of more powerful directed types of synaptic plasticity.

296 igh conversion rate in CO(2)RR and also make direct use of dilute CO(2) feedstocks.

297 mental model to understand the mechanisms of direct virus-induced neural-cell damage leading to demye

298 Direct visualization of neurotransmitter inputs to LC11

299 A direct-waveguide experiment shows that the propagation l

300 excitability: the annihilation of oppositely directed waves, all-or-none responsiveness, and refracto