ライフサイエンスコーパス: direct association

1 heir roles in LMP1 in vivo functions require direct association.

2 during checkpoint recovery, as well as their direct association.

3 cells, while in vitro pull-down assays show direct association.

4 manner, induces caspase-8 activation through direct association.

5 in immunoprecipitation assay, indicating its direct association.

6 d OmcA in wild-type Shewanella, suggesting a direct association.

7 se two fragments induce vacuolation requires direct association.

8 ng a role for SOCS-3 in deactivating JAK2 by direct association.

9 wever, there is little evidence to support a direct association.

10 promoter can modulate Runx2-P1 activity via direct association.

11 of complications of diabetes may explain the direct associations.

12 ein (YFP) were analyzed for FRET to indicate direct associations.

13 and we estimated average marginal controlled direct associations.

14 We report a significant direct association among palmitic, gamma-linolenic, palm

15 Genomewide or linkage-directed association analyses did not detect common vari

16 ptor (OPRM1)-mediated AC activation requires direct association and activation of Src kinase by lipid

17 ox10 induction of OL differentiation through direct association and antagonism of its function.

18 However, direct association and causal mechanisms between Salmone

19 junction with its juxta/transmembrane region direct association and inhibition of the Drosophila EGFR

20 I 3-kinase addback receptor, resulted in the direct association and selective activation of PI 3-kina

21 ustrial societies follows a 'J shape' with a direct association at high levels of average intake (ove

22 However, both the direct association (b = 0.033; P = .86) and the indirect

23 Here, we show a novel and direct association between a constituent of the PRC1 com

24 Here we show that the direct association between a p53 N-terminal peptide and

25 A direct association between Ab affinity and disulfide pol

26 In this report we demonstrate the direct association between actopaxin and ILK and dissect

27 Direct association between Akt1 and JIP1 was observed in

28 Using multiphoton imaging, we show a direct association between amyloid-beta deposits and fre

29 Results provide evidence of a direct association between antioxidant content of chocol

30 ls correlated with one another, there was no direct association between any of these cytokines and eo

31 omatin immunoprecipitation assays revealed a direct association between ARID3B and a specific ARID3B-

32 rtisol in infants, children, and adults, the direct association between asymmetry and cortisol has no

33 analyses of BAFF-induced signaling revealed direct association between augmented B cell metabolic fi

34 A statistically significant direct association between BMI and the odds of nonadvanc

35 ary to prior reports, we did not observe any direct association between changes in PCWP and changes i

36 wn an oncomodulatory effect of CMV; however, direct association between CMV infection and incidence o

37 To date, no imaging studies have revealed a direct association between collectivism and white matter

38 e lower maintenance doses of warfarin, but a direct association between CYP2C9 genotype and anticoagu

39 urgery study in PD patients do not support a direct association between DBS surgery and an increased

40 s associated with 8-oxoguanine is shown by a direct association between defects in the DNA glycosylas

41 Two of the longitudinal studies found a direct association between degree of overweight at basel

42 ey regulators of the actin cytoskeleton, the direct association between dematin and Ras-GRF2 may prov

43 A direct association between diet beverages and weight gai

44 ne impermeable cross-linking agent to show a direct association between extracellular domains of alph

45 We report an unexpected direct association between fascin, an actin-bundling com

46 There was a significant direct association between followup body mass and peak f

47 2 activity in a cell-free system in spite of direct association between GADD45 and PPARgamma proteins

48 This is the first detailed report showing a direct association between GM1 and alpha-synuclein, whic

49 transport associated with exocytosis, but a direct association between granular secretory proteins a

50 Principal component analysis revealed direct association between growth inhibition and MGo.

51 in the Tet(C/B) hybrid protein and suggest a direct association between helix 5 and helix 8 in the fu

52 There was also a direct association between higher blood pressures and a

53 Recent findings by our group demonstrated a direct association between HIV-1 infection and hematopoi

54 A direct association between HtrA and genetic competence w

55 By contrast, a direct association between IL-18 and IFN- gamma levels w

56 Accumulating evidence suggests a direct association between increased haematocrit and str

57 We show a direct association between increased turnover and decrea

58 E Our work demonstrates for the first time a direct association between infection with herpes simplex

59 In our previous study we discovered a direct association between InsP(3)R1 and protein phospha

60 sholds for aggressive behavior and support a direct association between low levels of serotonin homeo

61 re modest but comparable in magnitude to the direct association between maternal and child weight, wh

62 India and a less-consistent, dose-dependent, direct association between meat consumption and prevalen

63 merlin to regulate MLK3 activity requires a direct association between MLK3 and residues in the C-te

64 Intriguingly, we detected a direct association between mTORC2 and SCF-FBXW7; this as

65 These results highlight a direct association between myopenia, myosteatosis, and t

66 assays with recombinant proteins revealed a direct association between Nab2 and Gfd1, and two-hybrid

67 ontitis, and a further three studies found a direct association between obesity and development of pe

68 ffspring anxiety largely arises because of a direct association between parents and their children in

69 Although a direct association between PI3K and Mpl could not be dem

70 This motif is also required for a direct association between PKC alpha and beta 1 integrin

71 NaPB treatment increased the direct association between PKC and CREB followed by phos

72 Observational studies support a direct association between poor n-3 fatty acid status an

73 From this study, a direct association between protection against infection

74 Most demonstrated a direct association between PTE and neurodevelopmental ou

75 ry data in an end-to-end fashion, allowing a direct association between raw cytometry data and the cl

76 Here, we extend our studies to show a direct association between RD3 and guanylate cyclase act

77 There is a direct association between second-trimester maternal ser

78 A direct association between SLPI levels and the severity

79 A direct association between snacking between meals and T2

80 host cell infection is reduced, indicating a direct association between spore adherence and infectivi

81 These findings suggest a direct association between systemic microinflammation an

82 Our previous studies found a direct association between TDP-43 and heterogeneous nucl

83 These data establish a direct association between THC-induced NAcsh Penk upregu

84 Our modeling results demonstrate a direct association between the activities of AMPK and HI

85 Furthermore, this study establishes a direct association between the conformational energetics

86 n the observed geometric variations and show direct association between the conservations of the geom

87 grin signaling and Syk kinase function via a direct association between the Fgr SH2 domain and Syk ty

88 and immunoprecipitation analyses revealed a direct association between the GR and amino acids 203-60

89 We also showed a direct association between the in cis presence of the in

90 These findings suggest that there is a direct association between the interoceptive stimulus ef

91 However, a direct association between the inverse correlation of Sk

92 phosphorylation of S788 and S795 weakens the direct association between the N-terminal portion of RbC

93 a(+),K(+)-ATPase binding partners revealed a direct association between the Na(+),K(+)-ATPase and AS1

94 Additionally, there was a direct association between the number of positive Pseudo

95 l responses, studies have not demonstrated a direct association between the quantity of HIV-1 to whic

96 ation, properties that are consistent with a direct association between the receptor and the membrane

97 No direct association between the risk of fluid retention a

98 Interaction experiments support a direct association between the Rpb6 and Rpb4 subunits, i

99 Far Western analysis demonstrated a direct association between the two proteins, and peptide

100 The results of this study indicate a direct association between the V1/V2 and V3 loops of DH0

101 alleles at the haQTLs, implied a surprising direct association between these specific TF and local h

102 quires the Gp78 RING domain and occurs via a direct association between this region and MAVS.

103 Because direct association between TLQP-21 and gC1qR is required

104 Here, we provide evidence of a direct association between TorI and DnaJ using in vitro

105 that this genetic interaction is a result of direct association between TWIST1 and ETV proteins.

106 10(-8); OR = 0.82, 95% CI = 0.76-0.89) and a direct association between ULK4 rs2272007 and STAD (p =

107 The protection is linked to a direct association between viral particles and bacterial

108 Further evidence on the direct association between Vitamin D levels and the clin

109 nter, and multiple risk factors, there was a direct association between WBC count and incidence of co

110 To support this view, we show a direct association between WC-1 and NGF-1 that depends o

111 We observed modest direct associations between BPH and intakes of total ene

112 ate (NDP) kinase, and they also demonstrated direct associations between gp32 and RNR and NDP kinase,

113 We also established direct associations between hubs and validated drivers o

114 Overall, these findings indicate that the direct associations between language lateralization and

115 Of these, 13 found direct associations between Na and CVD, 8 found inverse

116 Our analysis revealed well-known direct associations between p16 mutant status and chemot

117 The network structure reveals direct associations between the variables and the joint

118 Direct associations between VKA therapy and incidence of

119 echanisms, including vesicle trafficking and direct association-dissociation of GTPase with membrane

120 Significant direct association for EBNA3B loci could only be shown w

121 bolic/inflammatory intermediates suggested a direct association for group 2, and magnified the one fo

122 Direct associations for smoking and alcohol, but not bod

123 n prediction may aid design and execution of direct association genotyping studies.

124 The direct association in men was observed for higher-glycem

125 oangiopathy (TMA), yet evidence supporting a direct association is often weak.

126 In vitro analysis demonstrated a direct association mediated through the IQ and kinase do

127 e studies from our laboratory demonstrated a direct association of 14-3-3 with the meningioma tumor s

128 KL10 peptide complex structure confirmed the direct association of 5G6 with its target GPIbalpha resi

129 th the same ODN (32P-labeled) demonstrated a direct association of a significant FRET signal with con

130 binding to alpha(5)beta(1)-integrin led to a direct association of alpha(5)-integrin with the recepto

131 of gap junction proteins is mediated by the direct association of an intracellular loop region of th

132 itation and Western blot analyses reveal the direct association of ARF6-HA with betacap73, defining a

133 Yeast two-hybrid screens confirm the direct association of Atp12p with the alpha-subunit and

134 and chromatin immunoprecipitation assays, a direct association of BAG-1 with the TGFB1 gene regulato

135 TPase subunit is necessary and sufficient to direct association of Bdf1 and Swc7, as well as Arp4, Ac

136 We found no direct association of blood pressure or antithrombotic r

137 The direct association of both IDP-like organic matter with

138 Direct association of BRD4 with acetylated H4 decreases

139 cipitation assays showed that JQ1 alters the direct association of BRD4 with acetylated histone-packa

140 ell communication is mediated in part by the direct association of calmodulin (CaM) with connexin43 (

141 K) derived from thrombospondin, indicating a direct association of CD47 with Gi.

142 s similar C-terminal dipeptide tails promote direct association of Cdc20, Cdh1 and Apc10-Doc1 with co

143 n experiments showed that insulin enhanced a direct association of cdc42 and p85, and both insulin tr

144 Thus, our observations suggest that the direct association of cyclin D3 with AML1 functions as a

145 According to the HCO3- metabolon hypothesis, direct association of cytosolic carbonic anhydrases (CAs

146 The findings are consistent with a direct association of different combinations of apoA-I h

147 This dNesp1 function does not depend on direct association of dNesp1 isoforms with the nuclear e

148 blot analysis of nuclear extracts revealed a direct association of E2F-1 with Pur alpha in the absenc

149 s into polymerization energy is regulated by direct association of each step in the hydrolysis reacti

150 to IR, with up to a 2.5-fold increase in the direct association of endogenous SHP2 with EGFR-wt in re

151 This inhibition results from a direct association of F-actin with the C terminus of Abl

152 g of Galpha(13) to the RH domain facilitates direct association of Galpha(13) to the DH domain to reg

153 urthermore, FRET-FLIM analyses confirmed the direct association of Grb14 and CEACAM3 in intact cells

154 ultisubstrate docking site that inhibits the direct association of Grb2 with cMet.

155 he risk of HCV transmission by analyzing the direct association of HCV with filters, water to dilute

156 t HDAC1 and HDAC2 target NF-kappaB through a direct association of HDAC1 with the Rel homology domain

157 specifically with mSin3A in vitro, showing a direct association of hSWI/SNF complexes with proteins i

158 T pull down assays demonstrated a strong and direct association of importin-alpha with endogenous Sgk

159 These results demonstrate a direct association of infarct size reduction with increa

160 Here we provide evidence that direct association of ING2 with the nuclear phosphoinosi

161 At multivariable analysis a significant direct association of interventricular septum thickness

162 A direct association of islet-autoreactive T cells with be

163 of Met in tumorigenesis was confirmed by the direct association of its deregulation to poor prognosis

164 Furthermore, ChIP assays reveal a direct association of KLF5 with both the Sox9 and Reg1A

165 Chromatin immunoprecipitations demonstrate a direct association of Lsh with the 5' DMR at the Cdkn1c

166 However, no known study has examined the direct association of magnesium and iron intake with pan

167 Direct association of menin with MLL fusion proteins is

168 Present findings provide insights into a direct association of Mgr2 with the channel-forming Tim2

169 Chromatin immunoprecipitation suggested a direct association of Mma10b with an 18-bp DNA binding m

170 Mechanistic experiments revealed direct association of MT4-MMP and its positive effects o

171 munoprecipitation and reporter assays reveal direct association of Myc with the Lin-28B promoter resu

172 own about the physiological relevance of the direct association of myosin-I with phospholipids or abo

173 ssively parallel DNA sequencing identified a direct association of NKX2-1 with the genes induced in m

174 results indicate that PSD-95 clustering and direct association of NR2A and PSD-95 mediate the blocki

175 Finally, we demonstrate that the direct association of PABPC with importin alpha is antag

176 The functional consequences of direct association of PLM with NCX1 was the inhibition o

177 med that there is either no association or a direct association of protein intake with elevated blood

178 Here we have identified a direct association of PSI with the spliceosomal U1 small

179 We observed colocalization and direct association of Rab25 with alpha5beta1-integrins.

180 A direct association of RAC1-GTP binding to phosphorylated

181 The direct association of RAP94 with NPH I, a DNA-dependent

182 In vitro and in vivo assays revealed a direct association of Sp1 and myogenin-MyoD mediated by

183 Several mechanisms, from the direct association of Src family kinases with GPCRs or r

184 A direct association of sTNF-R1 (2.37+/-0.13, 2.15+/-0.09,

185 Here, we question the direct association of structure to sequence by comparing

186 Co-immunoprecipitation assays showed direct association of tau and Ckidelta in situ, consiste

187 Our novel finding on the direct association of Th17 skewing and disease severity

188 a-EhAGO2-2 immunoprecipitation confirmed the direct association of the antisense sRNAs with EhAGO2-2.

189 We have also demonstrated a direct association of the chaperones with tau proteins.

190 nduces a signaling complex formation via the direct association of the docking protein p130(Cas) (Cas

191 by free G protein betagamma subunits and the direct association of the G protein alphas subunit with

192 ent work demonstrates, for the first time, a direct association of the MUC4 mucin with the metastatic

193 multaneous addition of Ngal and HGF leads to direct association of the two proteins, and results in a

194 ctivation and dopaminergic cell toxicity via direct association of these proteins in the nucleus, pro

195 However, direct association of villin with PIP(2) has never been

196 Confocal microscopy analysis demonstrated a direct association of virions with MTs, further supporti

197 cting partners for Tal1/SCL by demonstrating direct associations of Tal1/SCL with SATB1 and with Suv3

198 Mixed findings exist regarding direct associations of various sleep parameters and glyc

199 We show that human microRNA miR369-3 directs association of these proteins with the AREs to a

200 After adjusting for multiple testing, direct associations remained significant for 20 lipids,

201 We demonstrate that, unlike when testing direct associations, replacing the Bonferroni correction

202 This suggests that in addition to pTyr-directed associations, secondary interactions between th

203 Direct association studies between nonsynonymous single-

204 that coding-region SNPs (cSNPs) be used for direct association studies to determine the genetic basi

205 determinants and that analysis using linkage-directed association studies with dense SNP markers can

206 To demonstrate direct association, the non-interacting AFABP/aP2-D18K m

207 BRD4 direct association to chromatin regulatory regions of th

208 otein family are necessary and sufficient to direct association to heterologous intracellular lipid d

209 , whole-genome linkage analysis, and linkage-directed association to uncover genetic variants contrib

210 NCOA4-FTH1 interaction, we demonstrate that direct association via a key surface arginine in FTH1 an

211 This direct association was confirmed by glutathione S-transf

212 A direct association was demonstrated between Grb10 and p8

213 Direct association was detected between PLC-gamma2 and S

214 A direct association was found between c-erbB3 and c-erbB4

215 While no direct association was found between pulmonary artery pr

216 To test for direct association, we determined the spleen-somatic ind

217 The strongest direct associations were observed for extremely large ve

218 on measures to quantify indirect rather than direct associations while preserving valuable statistica

219 in of Spi-1/PU.1 functionally cooperates via direct association with a diverse collection of DNA-bind

220 opportunity to document pristine feathers in direct association with a putative juvenile coelurosaur,

221 by NSF/Sec18p-driven priming, allowing their direct association with a Rab/Ypt protein to activate do

222 ins (RBDs) and can also be activated through direct association with active GTP-bound Ras.

223 or TOR kinase in control of gene activity by direct association with an RNA polymerase II-transcribed

224 exerts its effects, at least in part, by the direct association with and inhibition of specific caspa

225 ening, rejuvenates mitochondrial function by direct association with ANT1 and the mitochondrial ATP s

226 itment domain (CARD), which is essential for direct association with Apaf-1 and activation.

227 le to link spindle status to the APC through direct association with APC core components.

228 rough a novel and anti-dogmatic mechanism of direct association with AR 6.9 kb 3'UTR and transcript s

229 ne acidic glycoprotein-75 does not support a direct association with banded collagen fibrils, but rat

230 ifficulties in detecting genetic variants of direct association with behavioral traits and disorders,

231 ycete Hyaloperonospora arabidopsidis through direct association with C-terminal LRRs.

232 nd that AMPK activates transcription through direct association with chromatin and phosphorylation of

233 unstructured tails of gammaretroviral INs to direct association with complexes at active promoters pa

234 icase proteins have seldom been described in direct association with components of the ribosome.

235 f Kek1 are critical for its function through direct association with DER, whereas its cytoplasmic dom

236 ruited during embryogenesis from myocytes in direct association with developing coronary arteries.

237 ne intact bromodomain and is mediated by its direct association with E2 proteins encoded by cancer-in

238 GFR membrane targeting and signaling through direct association with EGFR.

239 regulate the actin cytoskeleton of cells by direct association with F-actin and localization to foca

240 suggesting a minor role for this residue in direct association with Fbw7.

241 ssue demonstrated heavy PrP accumulations in direct association with FDCs in challenged wild-type and

242 ns Tbf1 is linked to the heterodimer through direct association with Fhl1.

243 There is a direct association with fracture and decreased quality o

244 ternal PBDEs and total T3 and total T4 and a direct association with free T3 and free T4 were observe

245 cyclin D1 enhanced H3K9 dimethylation though direct association with G9a.

246 receptor internalization, possibly through a direct association with Galpha(s).

247 Thus, PLIC-1 inhibits Gi signaling by direct association with Gbetagamma; because it also inte

248 sponsiveness by HDAC5 is mediated by HDAC5's direct association with HDAC4 and can occur by phosphory

249 r internalizing disorder onset through their direct association with high or increasing symptom level

250 ovement intervention group had the strongest direct association with higher quality of life (differen

251 whereas Q2 recruits the TFIID complex via a direct association with hTAF(II)130.

252 s, but although a growing matter of study, a direct association with immunosuppressive agents is not

253 ol downstream gene expression in response to direct association with intracellular metabolites or met

254 r proteins recruit kinesin-1 to vesicles via direct association with kinesin heavy chain (KHC), the f

255 were associated with better outcomes and in direct association with markers of atrial remodeling.

256 h its localization is accomplished through a direct association with mGluR6, the glutamate receptor e

257 Q1, 0.53 [95% CI, 0.36-0.78]) but had a weak direct association with MI among Black participants (HR

258 ologically as 'cheese-strainers', although a direct association with milk processing has not yet been

259 and certain uncommon beliefs demonstrated a direct association with minor violence.

260 myocardial infarction (MI) has a strong and direct association with mortality.

261 ulate the initial stage of cell spreading by direct association with N-WASP in the spreading initiati

262 E7 cells incubated with live bacteria and in direct association with N. gonorrhoeae were protected fr

263 ion induced by H. pylori infection through a direct association with nucleotide oligomerization domai

264 Because direct association with p11 is required for functional e

265 d that full activation of c-Cbl requires its direct association with phospho-tyrosines 1052 and 1057

266 anscribed chromatin through its SRI domain's direct association with phosphorylated Pol II.

267 Through direct association with pol II or by modulating the acti

268 ling molecules to the cytoskeleton via their direct association with proteins of the dystrophin prote

269 (HEXIM-1), regulates the pTEFb activity via direct association with pTEFb causing inhibition of the

270 Z and R to enhance lytic replication through direct association with R and/or R-induced alterations i

271 S6 kinase and mTOR complex 1 (TORC1), by its direct association with Rab GDP dissociation inhibitor b

272 hese functions of CeBRC-2 are dependent upon direct association with RAD-51 via its BRC motif and on

273 embranes has been reported to be mediated by direct association with Ras and by the phospholipase D p

274 sion in all organisms, in some cases through direct association with RNA polymerase (RNAP).

275 r of renal function, has a stronger and more direct association with SBI in the elderly.

276 requires an adapter protein, Cks1, to be in direct association with Skp2.

277 Consistent with its direct association with stroke, the Hp 1-1 genotype is a

278 yl-beta-D-lactoside, were similarly found in direct association with such intramembrane particle aggr

279 munoprecipitation experiments did not detect direct association with synaptic vesicle protein 2.

280 n related to death indirectly via their more direct association with systemic inflammation.

281 to focal adhesions, potentially through its direct association with the amino terminus of actopaxin,

282 mediated at the transcriptional level by its direct association with the c-jun gene promoter.

283 By virtue of its direct association with the cardiovascular (CV) function

284 The inhibitory action of MCIP1 involves a direct association with the catalytic domain of calcineu

285 eing part of the complex, no evidence of its direct association with the channel was obtained.

286 cells differentiate from cardiac myocytes in direct association with the developing endocardium and c

287 protein represses EGR1 expression through a direct association with the EGR1 promoter.

288 rated internalization and resurfacing due to direct association with the endocytic receptor alpha(2)-

289 expression in myeloma cells is regulated via direct association with the heat shock protein 90 (HSP90

290 were completely extracted, suggesting their direct association with the membrane part of the enzyme

291 iption and replication of the EBOV genome by direct association with the ribonucleoprotein complex in

292 provide evidence that TORC2 is activated by direct association with the ribosome, which may ensure t

293 itinating activity of the ligase complex via direct association with the Skp protein.

294 276 without; z = 3.595; P <.001), although a direct association with this CD20 B-cell-directed therap

295 ntumor tissue (N = 48), thus revealing their direct association with tumor metabolism.

296 Both probing depth and CAL had direct associations with all-cause dementia among Hp(+)

297 Prenatal MeHg exposure had no direct associations with neurodevelopmental outcomes.

298 e recruited to chromatin through independent direct associations with PCNA.

299 tinguishes residue-residue interactions from direct associations with PIs.

300 interacts with hsc70 and an LXCXE motif that directs association with Rb proteins.