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1 ppress WOX1 and PRS expression, also through direct binding.
2 emoreceptor that mediates QACs taxis through direct binding.
3 nucleotide-binding protein 1 (HINT1) through direct binding.
4 and AMOT family members control YAP through direct binding.
5 onjugated Sepharose 4B beads confirmed their direct binding.
6 7 inhibits processing of these pri-miRNAs by direct binding.
7 kinase 3 (FLT3) is transactivated by SYK via direct binding.
8 A splicing factors CUG-BP and hnRNPM through direct binding.
9 istone-like nucleoid structuring protein via direct binding.
10 entify 3E10 as a novel inhibitor of RAD51 by direct binding, accounting for its ability to suppress H
11 e, the Nan-EKLF protein accomplishes this by direct binding and aberrant activation of genes encoding
12 may induce kidney tissue remodeling through direct binding and activation of the renal EGF receptor.
13 ted HLA-DRalpha at the protein level through direct binding and degradation through the proteasome pa
15 ncHIFCAR forms a complex with HIF-1alpha via direct binding and facilitates the recruitment of HIF-1a
19 , Esrrb sustains the stemness of TS cells by direct binding and regulation of TS cell-specific transc
20 errihydrite, which is in line with a lack of direct binding and reported slow transformation to dimet
22 lex elicited approximately 100-fold lower V3-directed binding and neutralization titers than those ob
24 it is necessary to introduce the notions of directed binding and valence which result in the concept
25 small peptide (SpyTag, 13 amino acids) that directs binding and formation of a covalent bond with it
26 biosensors measure reaction kinetics through direct binding, and with higher throughout, impacting li
27 creatic EVs limit IAPP amyloid formation via direct binding as a tissue-specific control mechanism.
28 cessful development of a fluorescence-based, direct binding assay for the detection of type II and II
29 nction studies of the ETA protein, through a direct binding assay, and pharmacological and genetic ap
31 tinylation followed by mass spectrometry and direct binding assays to identify proteins that associat
33 ur study, combining electrophysiological and direct binding assays, demonstrates that hEAG1 channels
35 proteins, this work is the first to utilize direct binding assays, X-ray crystallography, and modeli
38 rapid phosphorylation of STAT4, resulting in direct binding at the granzyme B promoter within 2 h of
39 nthase activity in AD pathology results from direct binding between Abeta and ATP synthase and inhibi
40 ) mapping to the ATPase domain cause loss of direct binding between BAF and PRC1 that occurs independ
41 increase in MCT transport activity requires direct binding between CAIV-His-88 and a charged amino a
42 recognise and communicate with each other by direct binding between cell surface receptor and ligand
44 eraction by coimmunoprecipitation and showed direct binding between dAmph-SH3 domain and dNedd4Lo N-t
45 HITS-CLIP) and biochemical analyses revealed direct binding between endogenous TruB1 and the stem-loo
47 n of MCT transport activity by CAII requires direct binding between histidine 64 in CAII and a cluste
53 we describe a regulatory mechanism involving direct binding between tail and motor domains and its fu
54 tion reveals that, surprisingly, there is no direct binding between the adsorbed CO2/CH4 molecules an
55 et al. and Chen et al. provide evidence for direct binding between the cytoplasmic tails of receptor
56 urements performed in parallel confirmed the direct binding between the vapor molecules and the pepti
57 e for Rod-complex initiation, either through direct binding by PBP2 or through an unknown intermediat
58 a model where CHK2 sequesters the AR through direct binding decreasing AR transcription and suppressi
60 rally unresolved N-terminal APN region using direct binding fluorescence polarization assays and ther
64 In vivo, 5: maintained high, alphavbeta6-directed binding in the paired DX3purobeta6-DX3puro mode
65 irst time, the experimental observation of a direct binding interaction between adsorbed CH4 molecule
66 and pull-down assays, we discovered a novel, direct binding interaction between the cytoplasmic tail
68 roperties of C1-CBP-vancomycin, suggesting a direct binding interaction with embedded teichoic acid i
69 ruggability is mainly studied by focusing on direct binding interactions between a drug and its targe
73 e M-CSFM variants with mutations both in the direct binding interface and distant from the binding si
75 culated from binding plots and compared with direct binding measurements using ultracentrifugation as
76 cium-bound calmodulin (Ca(2+)/CaM) through a direct binding mechanism involving a regulatory C-termin
78 by substantial conformational changes, with direct binding mediated by the carboxy termini of Dam1p
79 the drugs tested here may block infection by direct binding near these critical sites for virus entry
82 ompelling evidence for a mechanism involving direct binding of a water molecule trans to the oxo atom
83 ther prove that CRLF2-ligand TSLP boosts the direct binding of active PTPN11 to wtRAS, providing the
92 ilitation of MCT transport activity requires direct binding of CAIV to the transporters chaperones.
93 Moreover, cell-free experiments revealed direct binding of CAPS1 to Rbcn3beta/WDR7, and cell assa
94 ted with exogenous CCL28, which also induced direct binding of CCR10 and eNOS resulting in inhibition
96 S2R+ cells, our data revealed an unexpected direct binding of Corkscrew, the drosophila ortholog of
100 , as demonstrated by genome-wide RNA-seq and direct binding of Dmrta2 to the Hes1 genomic locus.
103 hroughout the chondrocyte genome, reflecting direct binding of each factor to the same enhancers and
105 d PRDM1 (BLIMP-1) transcription results from direct binding of EBNA3A and EBNA3C to regulatory elemen
113 ifier potassium (GIRK) channels are gated by direct binding of G protein beta-gamma subunits (Gbetaga
114 the presynaptic active zone and, second, the direct binding of Gbetagamma to the SNARE complex to dis
117 o indicate that the ARC gene is regulated by direct binding of HIF1 to a hypoxia response element (HR
119 nd CD24 was transcriptionally upregulated by direct binding of HOXA5 to their promoter sequences as d
122 changes in filopodium dynamics by increasing direct binding of its receptor, Robo, to members of the
123 trophoretic mobility shift assays revealed a direct binding of KLF9 to the putative KLF binding motif
124 ndent RNA structural alterations can promote direct binding of m6A-modified RNAs to low-complexity re
127 ls that this specificity is achieved through direct binding of MEDI-579 Fab to the reactive centre lo
128 h 3 distinct mechanisms: 1) reduction and/or direct binding of metalloprotein heme centers, 2) servin
130 sion changes could be explained by predicted direct binding of miRNAs to corresponding mRNAs, suggest
132 on and luciferase reporter assays revealed a direct binding of NANOG to a transcriptionally active si
134 noprecipitation and TOPflash assays revealed direct binding of Nog to Wnts to functionally prevent Wn
136 Suppression of bud growth may be attained by direct binding of NtBRCs to the Tassels Replace Upper Ea
137 hanism of transport for EcNhaA has suggested direct binding of one of the transported H(+) to the con
139 itation-qPCR (ChIP-qPCR), we did not observe direct binding of p53 to MIR182, MIR203, MIR222, and MIR
140 ctivates NFkappaB signalling, leading to the direct binding of p65 to the promoter of Beclin 1 and to
142 old relative to an empty vector control, and direct binding of Pdx-1 to the proximal SERCA2 promoter
143 uman serotonin transporter (hSERT), in which direct binding of phosphatidylinositol 4,5-bisphosphate
144 f full-length human PIRT and investigate the direct binding of PIRT to PIP(2) and the human TRPM8 S1-
146 nscription factors (LDTFs) contribute to the direct binding of PPARgamma in different cellular contex
147 des to be strong MHC class I binders through direct binding of predicted peptides to MHC proteins in
149 mice carrying Smad4 conditional deletion and direct binding of pSmad1/5/8 to the Hcn4 regulatory regi
150 emonstrate that phosphorylation controls the direct binding of purified Lgl2 to negative phospholipid
152 B counteract genome-destabilizing effects of direct binding of RAD51 to dsDNA in human tumor cells.
153 cell cycle independent, and instead reflects direct binding of Rb to pluripotency genes, including So
154 achieved through two general strategies: (1) direct binding of receptors to microbial or host-derived
156 atom-bound motif RS(*)Au(0)S(*)R or involves direct binding of RS(*) to face-centered-cubic or hexago
157 11/12 (the Tup-family corepressors) suppress direct binding of Rst2 to UAS2, but this suppression is
158 n blot to identify the receptors involved in direct binding of RSV and pneumococci, the effects of wh
159 previously not linked to PRC2, we confirmed direct binding of Scm and PRC2 using recombinant protein
161 nd biochemical data support a model in which direct binding of Slit to Dscam1 enhances the interactio
163 ng intrinsic or acquired drug resistance via direct binding of STAT3 in IGF2 P3 and P4 promoters.
166 tribute to outer membrane biogenesis through direct binding of substrates and/or protein-protein asso
167 tested it in a range of assays that measured direct binding of Tau to glycosaminoglycans and inhibiti
168 romatin immunoprecipitation assays confirmed direct binding of TCF/LEF factors to the promoter and pu
169 s with the active telomerase complex through direct binding of TERC and regulates Cajal body localiza
172 that the AP-4-FHF interaction is mediated by direct binding of the AP-4 mu4 subunit to coiled-coil do
173 l interaction between MCT4 and CAII requires direct binding of the enzyme to the acidic cluster (431)
174 inations of subunits (GIRK1-4), activated by direct binding of the Gbetagamma subunit of Gi/o protein
175 tion inhibits TRPM3 channel activity through direct binding of the Gbetagamma subunit to the channel.
176 vo protein-mapping techniques to demonstrate direct binding of the heterologous Nhp6A protein at a La
178 on of ERK5 transcriptional activity requires direct binding of the inhibitor to the kinase domain.
179 Early RA treatment prevents this switch by direct binding of the RA receptor at the GLI3 promoter.
181 as identified upstream of the impA gene, and direct binding of the site by ExsA was demonstrated via
182 ls stably expressing TRPM8 further confirmed direct binding of the steroid hormone, testosterone, to
183 ereby beta3 integrin activation involves the direct binding of the talin head domain to the switch re
184 agging using this engineered ligase requires direct binding of the target and, thus, provides a usefu
189 l titration calorimetry, we also demonstrate direct binding of U46619 and cysteinyl leukotrienes C(4)
191 on followed by sequencing (ChIP-seq) reveals direct binding of URI to promoters of many iron-regulate
195 c properties of its carbonyl oxygen atoms, a directed binding of the substrate to the template is pos
197 l Mean Force, we showed that Arg is prone to direct binding onto the NP surface, while Lys needs to o
198 In contrast, MKK7alpha and beta exhibited no direct binding or FRET with CaN and were localized more
199 ment of the bound label-antibody fraction in direct binding or sandwich-assay type approaches with va
203 ubunit of the Sec61 protein translocon, as a direct binding partner of ipomoeassin F in living cells.
204 the branched actin regulator cortactin as a direct binding partner of phosphatidylinositol 3,5-bisph
205 rotein component of caveolar membranes, is a direct binding partner of Sirt1, as shown by the binding
207 rovilli, the site of IMAC function, and is a direct binding partner of the IMAC component myosin-7b.
209 TCP1 subunit 6A (CCT6A) as an inhibitor and direct binding protein of SMAD2 and found that CCT6A sup
210 h a fluorescent dye for visualization of the direct-binding protein targets of curcumin in situ.
211 evidence of allosteric coupling between the direct binding site and the NBD1:CL4 interface, thus ena
212 ence for this mechanism of action comes from direct binding studies between CD14 and MD2 with POPG an
219 PUM1/2 rather promote FOXP1 expression by a direct binding to 2 canonical PUM responsive elements pr
221 most conotoxin channel blockers function by direct binding to a channel and disrupting its normal io
222 ivity by preventing processing of miR-22 via direct binding to a conserved ERalpha-binding element wi
223 ptional repressor and regulated IFN-beta via direct binding to a previously unidentified specific reg
225 ating seed oil biosynthesis was fulfilled by direct binding to a RY (CATGCA) cis-regulatory element i
227 chanical link at the Muller cell membrane by direct binding to actin and a transmembrane protein comp
228 ibution of Na(+),K(+)-ATPase is modulated by direct binding to Akt substrate of 160 kD (AS160), a Rab
230 ress by the NF-E2-related factor 2 (NRF2) by direct binding to an antioxidant response element in the
232 ammasome and NF-kappaB signaling pathways by direct binding to ASC1 and NF-kappaB1, respectively.
234 role in activation of AP-1 target genes via direct binding to c-Jun at the target promoters, leading
235 ded by bone vascular niche E-selectin, whose direct binding to cancer cells promotes bone metastasis
237 ontributes to S. aureus invasion of A549 via direct binding to CD36 of the complex CD36-TLR-2, and LT
238 lved in the different CDCs to preferentially direct binding to cholesterol in different lipid environ
243 of GAP activity of ELMOD1-3 proteins as its direct binding to either ELMOD1 or ELMOD2 resulted in lo
247 sses TNBC progression and metastasis through direct binding to integrin alpha5beta1, alphavbeta1, and
248 at miR-24 inhibits Jab1/CSN5 translation via direct binding to its 3' untranslated region (3'UTR) and
251 ession, a homolog of plant CONSTANS (CO), by direct binding to its promoter, while it reduces the exp
253 ic cells through two independent mechanisms: direct binding to L1 RNA and regulation of a cellular fa
254 disordered tail of TtBac is responsible for direct binding to lipid membranes, both on liposomes and
255 Pil1, generates these invaginations through direct binding to lipids including phosphoinositides.
256 tory roles in the pathogenesis of PH via the direct binding to messenger RNA transcripts for degradat
257 is unclear, as current models indicate that direct binding to minichromosome maintenance (MCM) plays
258 etalloproteinase 3 (MMP3) expression without direct binding to MMP3 promoter and increased the 5-hydr
260 tically, Cn promotes gene expression through direct binding to myogenic promoter sequences and facili
261 tion by two distinct mechanisms: firstly, by direct binding to Nurr1's ligand-binding domain and prom
263 istant conformation that is relaxed upon its direct binding to PAM, allowing hPm to form and provide
264 idues within the CCD of ATG16L1 that mediate direct binding to phosphoinositides, including phosphati
265 amily member J by releasing RhoGEF Tuba from direct binding to PlexinD1, thus mediating endothelial c
268 L across endothelial monolayers requires its direct binding to SR-B1 and an eight-amino-acid cytoplas
269 ptor subfamily B member 2 (LilrB2) exhibited direct binding to synaptotoxic assemblies of synthetic A
270 reactions, including the hapten hypothesis, direct binding to T-cell receptors (the pharmacologic in
271 evels through pleiotropic effects, including direct binding to the 3' untranslated region of VWF and
274 a novel mechanism of BAX inhibition through direct binding to the BAX N-terminal activation site.
275 retards mitotic progression in host cell by direct binding to the C terminus of Microtubule-Associat
277 by multiple divergent Cas9 orthologs through direct binding to the conserved HNH catalytic domain of
278 sor, regulates germ cell differentiation via direct binding to the Cyp26b1 promoter and thus inhibits
279 orts the chemotherapeutic drug cisplatin via direct binding to the ectodomain, we demonstrate that th
280 ens or wounding to induce innate immunity by direct binding to the membrane-localized leucine-rich re
282 tor signaling in smooth muscle cells through direct binding to the N-terminal region of myocardin.
283 that Cdk1 phosphorylates Ska3 to promote its direct binding to the Ndc80 complex (Ndc80C), a core out
284 odulate inhibitory postsynaptic signaling by direct binding to the postsynaptic scaffolding protein g
289 main are associated with altered patterns of direct binding to the RAD51C, RAD51 and BRCA2 HR protein
293 nuation of TLR4 signaling in vitro and their direct binding to TLR4-myeloid differentiation-2 (MD-2)
296 of three different Mg(2+) binding modes: 1) direct binding via N7 coordination, 2) direct binding vi
297 s: 1) direct binding via N7 coordination, 2) direct binding via O6 coordination, and 3) binding via h
299 Short ubiquitin chains recruit NEIL3 through direct binding, whereas longer chains are required for t
300 esis by enhancing TGFbeta1 signaling through direct binding with and stabilization of TGFBR1 in lung