ライフサイエンスコーパス: direct evidence

1 measurement of insulin output would be more direct evidence.

2 lls for almost two decades despite a lack of direct evidence.

3 potential effect in the absence of stronger direct evidence.

4 do more good than harm, but there was little direct evidence.

5 ed in the pathogenesis of schizophrenia, but direct evidence and a mechanistic link are still missing

6 However, direct evidence and characterization of individual airwa

7 The ongoing dal-GenE study will provide direct evidence as to whether there is any specific phar

8 Yet, direct evidence causally implicating inhibitory signalin

9 The present data provided direct evidence confirming and extending the view of imp

10 This work provides direct evidence demonstrating that a collagen-based woun

11 Direct evidence demonstrating that these APOL1 risk alle

12 ial remains, is challenged by the paucity of direct evidence demonstrating who was involved in produc

13 e came from studies of cell lines and yet no direct evidence exists for tissues.

14 the opening of the RagB lid and thus provide direct evidence for a 'pedal bin' mechanism of nutrient

15 on partially delithiated crystals, providing direct evidence for a concurrent nucleation and growth p

16 Our findings provide direct evidence for a key role of a dysfunctional eIF2al

17 We provide direct evidence for a progressive reduction of the densi

18 We provide direct evidence for a reversal of the perceptual feed-fo

19 However, direct evidence for a role of these toxins in CKD-relate

20 Direct evidence for a solid-electrolyte inductive effect

21 innate and learned visual responses provides direct evidence for a specific role of the MB in navigat

22 This study may offer direct evidence for adhesive loose packings comprising d

23 iotic strains can cause bacteremia(8,9), yet direct evidence for an ancestral link between blood isol

24 We provide the first direct evidence for an elusive reaction intermediate and

25 o attentional focusing in memory, we provide direct evidence for an involuntary "retro-capture" effec

26 langes, tarsals and metapodials, constitutes direct evidence for carnivore skinning and, presumably,

27 Direct evidence for charge build-up within protein multi

28 In a recent paper, Sharon et al. report direct evidence for coevolution between TCR and MHC gene

29 These results provide direct evidence for conjunctive representations as criti

30 However, direct evidence for cooking of bone has been limited.

31 This includes direct evidence for DNA contacts to the residues extendi

32 This provides the first direct evidence for downstream recapping.

33 Direct evidence for economic indicators as predictors of

34 odel in fish we provide, for the first time, direct evidence for genetic variation in host infectivit

35 eoxyadenosyl radical, and provides the first direct evidence for homolytic S-CH(3) bond cleavage in a

36 l for sound recognition, yet there is little direct evidence for how frequency selectivity is preserv

37 ailed map of IAV genome structure to provide direct evidence for how intersegment RNA interactions dr

38 Thus, our observations provide direct evidence for hydrothermal vents acting as a sourc

39 that TMEM165 has cation transport activity, direct evidence for its Ca(2+)- and Mn(2+)-transporting

40 learning-related plasticity in motor cortex, direct evidence for its involvement in memory consolidat

41 an oncogene in different human cancers, but direct evidence for its role in tumorigenesis has been l

42 izes the C-type gate 'leak mode' and provide direct evidence for K2P selectivity filter gating.

43 liquid water in operating cells. We provide direct evidence for liquid water accumulation at the ano

44 This work provides direct evidence for LLPS in bacteria and demonstrates th

45 These results provide direct evidence for magnetotail reconnection onset cause

46 epression (LTD), and last year saw the first direct evidence for memory storage by CaMKII.

47 Small-angle neutron scattering provides direct evidence for mesoscale magnetic structure that we

48 In sum, we present the first direct evidence for mGluR5 hypoactivity, propose a recip

49 Here we show direct evidence for mid-crustal magma storage beneath th

50 These data provide the earliest direct evidence for milk product consumption and reveal

51 Our results provide direct evidence for neural plasticity that compensates f

52 re-programmed reactions, the results provide direct evidence for not only the presence of encaged hyd

53 Direct evidence for partitioning of the magnetic cations

54 Rationale: Direct evidence for persistence of Mycobacterium tubercu

55 Until recently, a dearth of direct evidence for prehistoric human diet and subsisten

56 Here, we present direct evidence for propagating solid-like longitudinal

57 Overall, our results provide direct evidence for retrotransposons in actively shaping

58 However, there is a lack of direct evidence for RNA G-quadruplex formation in living

59 However, direct evidence for RSPO-bound, full-length LGR5 interac

60 Notably, these methods give direct evidence for several anticipated differences in t

61 Although we do not provide direct evidence for strong or consistent biodiversity-ec

62 neuron-network coupling profiles, providing direct evidence for subtype specificity.

63 ls in mossy fibers and granule cells provide direct evidence for such matching.

64 However, direct evidence for such sequence replay is limited to o

65 These data provide direct evidence for the 50 year old hypothesis that a cu

66 al as a drug target against trypanosomatids, direct evidence for the cellular function and essentiali

67 local speed of mRNA translation and provide direct evidence for the central role of cellular tRNA le

68 erovskite methylammonium lead iodide (MAPI); direct evidence for the chemical source of this stabilit

69 There was no direct evidence for the clinical benefits and harms of H

70 This study thus provides direct evidence for the crucial role of Nrf2 in protecti

71 We present here direct evidence for the existence of complex, thermally

72 of adjacent His37 imidazole rings, providing direct evidence for the existence of various imidazolium

73 The results provide unprecedented direct evidence for the formation of a [Cu(2)(NH(3))(4)O

74 scattering with contrast variation provides direct evidence for the formation of THF-rich nanocluste

75 stance of fossilized predation that provides direct evidence for the function of dorsoventrally expan

76 We also provide direct evidence for the idea that value-based attention

77 rmation than Mdm2(SNP309T/T) mice, providing direct evidence for the impact of this SNP in tumor deve

78 Although this model is widespread, direct evidence for the individual steps is lacking.

79 Nakwai, Kenya, dated at ~22 Ma, that offers direct evidence for the initial key steps in the evoluti

80 umulation in aquatic plants, but there is no direct evidence for the internalization of nanoplastics

81 antiviral response, we were able to provide direct evidence for the long-standing hypothesis that in

82 carbon-sulfur with LTO membrane, we provide direct evidence for the migration, adsorption, and confi

83 Our findings provide direct evidence for the notion that the ACC has a role i

84 Our findings represent the first direct evidence for the polymeric nature of pDA and prov

85 wy bodies and other alpha-synucleinopathies, direct evidence for the precise synaptic localization ha

86 To obtain direct evidence for the presence of these uracils, we en

87 This provides unique direct evidence for the role of submesoscale fronts in g

88 The Le Rozel footprints thus provide direct evidence for the size and composition of a Neande

89 In particular, there is little direct evidence for the specific conformational changes

90 However, direct evidence for the spontaneous formation of OR dime

91 There is little direct evidence for the synaptic basis of neurons' funct

92 f an in vivo cell labeling method we provide direct evidence for the systemic dissemination of rTEM n

93 To obtain direct evidence for the transfer and accumulation of pla

94 thus complement earlier findings and provide direct evidence for the unified theory of unexpected eve

95 icted to be present in the human genome, but direct evidence for their biological function is scarce.

96 highly sensitive to context, but robust and direct evidence for them in a naturalistic setting is sc

97 However, direct evidence for this AE front has been elusive given

98 not been confirmed in knockdown studies and direct evidence for this function is lacking.

99 hromatin loops until it encounters CTCF, but direct evidence for this hypothesis is missing.

100 Contrary to Plasmodium vivax, direct evidence for this hypothesis is scarce.

101 necessary to adapt to a changing world, but direct evidence for this is lacking in humans.

102 However, direct evidence for this model was missing.

103 However, direct evidence for this role in catalysis has yet to be

104 best of our knowledge, represents the first direct evidence for this site being used to access the h

105 This study provided direct evidence for understanding the role of CNTs/MnO2

106 This work provides direct evidence for unique conformational states that oc

107 In this study, we present direct evidence for water dissociation equilibrium on ru

108 a pathophysiological pathway to autism, but direct evidence from humans is lacking.

109 he formation of complex memory episodes, but direct evidence from humans is missing.

110 Direct evidence in humans for the impact of the microbio

111 These results provide direct evidence in support of a measurable solid-electro

112 Direct evidence in support of this hypothesis, however,

113 Indirect and direct evidence indicates that a significant fraction of

114 nizes the genome through loop extrusion, but direct evidence is lacking.

115 eading to methodological artifacts, although direct evidence is lacking.

116 osphate fluxes and cellular homeostasis, but direct evidence is missing.

117 that occur during stroke recovery; however, direct evidence is missing.

118 protein assignment for SPN3US gp22, although direct evidence is required for its confirmation.

119 remote, pristine atmospheric regions(4), but direct evidence is sparse, and the magnitude of this con

120 However, direct evidence is still lacking due to the lack of a ve

121 res are related to grain structure, although direct evidence linking crystal microstructure to the PT

122 of single-particle thermal trajectories and direct evidence of a "cold phase transformation" process

123 cing and single-cell transcriptomics yielded direct evidence of a parallel boost of 2 clonally and fu

124 In the current paper, we look for direct evidence of a relationship between temporal disco

125 Here we present direct evidence of abundant CO(2) in basaltic rocks from

126 ity contribute to CRC development, providing direct evidence of an association between obesity and CR

127 These findings provide the first direct evidence of an effective treatment of peripheral

128 ochleariae PGs in vitro, providing the first direct evidence of an interaction between a plant PGIP a

129 As fossilized feces, coprolites represent direct evidence of animal behavior captured in the fossi

130 sense, these changing conditions constitute direct evidence of anthropogenic climate change.

131 ulin secretion by the pancreatic beta-cells, direct evidence of CCK promoting insulin release in huma

132 This work is a direct evidence of charge transport control in a protein

133 n/Davis-Beirut reaction and are presented as direct evidence of competent oxygenated intermediates; m

134 Herein, we report the direct evidence of CT mechanism in 2D Cu-THQ MOFs and th

135 atigraphically and phylogenetically earliest direct evidence of ecdysis within total-group Euarthropo

136 The data provide direct evidence of electron transfer involving the lowes

137 We did not find direct evidence of endothelial activation.

138 ses, however, preserved gut contents provide direct evidence of feeding strategy and species interact

139 Here we show direct evidence of fibre technology in the form of a 3-p

140 eens from personalized vaccine studies shows direct evidence of fs-indel derived neoantigens elicitin

141 Direct evidence of gymnospermous Cycadopites pollen is a

142 They provide direct evidence of how Rad51 is required for meiotic rec

143 This direct evidence of impaired Ca(2+) handling in nBMP2 mut

144 ferences are found to be negligible, we find direct evidence of increased planetary albedo primarily

145 el of naturally aging mice and rats, we show direct evidence of increased proton leak in the aged hea

146 serine codons during protein synthesis, but direct evidence of its cotranslational incorporation is

147 We provide direct evidence of its doubly magic nature, which is als

148 hanging other binding parameters and provide direct evidence of kinetic proofreading in T cell signal

149 This represents direct evidence of magmatic activity in a carbonaceous a

150 Here, we report direct evidence of multi-drug resistance among foals tre

151 nging from 12 m up to about 100 m, providing direct evidence of multiple lava-infilling events that o

152 We found direct evidence of multiple polyphenolic compounds in th

153 al selection [2, 6-8], but there has been no direct evidence of natural selection acting on spatial m

154 Direct evidence of physical contacts between chromosomes

155 Here, we provide direct evidence of Re enrichment to crystalline defects

156 lded in both Arabidopsis and rice, providing direct evidence of RNA G-quadruplex formation in living

157 However, direct evidence of Sb sequestration in natural peat samp

158 These findings provide direct evidence of seabird exposure to plastic additives

159 There is no direct evidence of severe acute respiratory syndrome cor

160 Direct evidence of successful or failed predation is rar

161 s as a consumer of 'hard' invertebrates) and direct evidence of sympatric niche partitioning (Rhampho

162 We provide direct evidence of T cell transduction through the detec

163 This report also provides direct evidence of telomerase activation in HBECs near s

164 To date, there is no direct evidence of telomerase activity in adult lung epi

165 n integrins and the actin cytoskeleton; yet, direct evidence of tensin's role in mechanotransduction

166 Our results provide the first direct evidence of the anti-RSV activity of 3,4-DCQAME.

167 ke taxon from the same locality(13) provides direct evidence of the co-occurrence of crown birds and

168 d from real-time observations, which provide direct evidence of the colloidal stability of side-to-si

169 n of a plutonium chain side product provides direct evidence of the competition that occurs between m

170 terrestrial, and omnivorous animal provides direct evidence of the deep history of directional behav

171 The Xiahe specimen provides direct evidence of the Denisovans outside the Altai Moun

172 We aim at gaining more direct evidence of the environment-microbiota-health axi

173 d management of hypertension in Cuba, and no direct evidence of the expected benefit of such efforts

174 loidization after transplantation, providing direct evidence of the hepatocyte ploidy conveyor model.

175 An underlying mechanism is proposed based on direct evidence of the in-situ-captured reaction interme

176 to circulating and marginating pools, but no direct evidence of the latter has been obtained so far.

177 isms, and neuroglial involvement provide the direct evidence of the novel effects of caffeine therapy

178 asmic C-terminal domain, providing the first direct evidence of the phospho-regulation of MmpL11 tran

179 his approach allowed us to provide the first direct evidence of the pivotal role of this protein duri

180 Nonetheless, direct evidence of the role of LRRC8A in astrocytic regu

181 cue settings to provide, for the first time, direct evidence of the role of the actin-binding protein

182 These findings provide the first direct evidence of the role the maturase plays during gr

183 Direct evidence of the successful incorporation of atomi

184 The findings provide high-resolution direct evidence of the twinning nucleation mechanism in

185 Also, direct evidence of the underlying interregional assembly

186 t as a source of geomagnetic pulsations, but direct evidence of the waves and their role in magnetosp

187 d on non-inferiority trials that provided no direct evidence of their efficacy against multidrug-resi

188 These results provide direct evidence of this effect, which has long been a ma

189 raday pail/electrometer set up, which brings direct evidence of triboeletricity being a mosaic of pos

190 h hyperpolarized xenon, we produce the first direct evidence of UCP1-independent BAT thermogenesis in

191 s is the first comprehensive study providing direct evidence of undefined unique pathological changes

192 However, there is still no direct evidence on CeA GABAergic neurons' real-time dyna

193 to-head randomised trials would also provide direct evidence on comparative effectiveness and safety

194 There remains no direct evidence on effects of prenatal screening vs no s

195 There was no direct evidence on the benefits or harms of screening ch

196 to screen for drug use, although there is no direct evidence on the benefits or harms of screening.

197 pregnant adolescents and adults there was no direct evidence on the clinical benefits and harms of sc

198 Direct evidence on the effects of HCV screening on clini

199 Our results provide direct evidence on the key role of the photochemical pro

200 cal theories and highlights the need for the direct evidence presented by in situ techniques such as

201 as a landmark event in human evolution, with direct evidence provided by stable carbon isotope studie

202 d potentially other terrestrial planets, yet direct evidence remains elusive.

203 altered high-latitude forests globally, but direct evidence remains rare.

204 However, there is a lack of direct evidence showing that dopamine function is causal

205 Yet limited direct evidence supports the link between planning and t

206 Here, we provide direct evidence that Abeta42/40 ratio, not total Abeta l

207 Collectively, this study provides direct evidence that allosterism in CRY1 is critical for

208 These findings provide direct evidence that an N-fixing tree species can also a

209 Here, we provide direct evidence that another's perspective can "stand in

210 There is, however, no direct evidence that ants require MBs for visual navigat

211 Furthermore, we provide direct evidence that AtMCU1 activity is sensitive to the

212 We provide direct evidence that bacteria reside in the bladder wall

213 sualizing nanoscale BCR clusters, we provide direct evidence that BCR cluster size increases with F(a

214 knowledge, these findings provide the first direct evidence that BP180 plays an important role in gr

215 This study provides the first direct evidence that BP180, a cell-cell matrix adhesion

216 a C5L2-siRNA silencing strategy, we provide direct evidence that C5L2 constitutes a negative regulat

217 iatal dopamine may underlie the association, direct evidence that cannabis use affects either acute o

218 Furthermore, these results provide the first direct evidence that CDF CTDs play a role in metal selec

219 Here we provide direct evidence that cell-scale mechanical deformation c

220 These results provide direct evidence that co-operation between CD4(+) and CD8

221 Together, these data provide direct evidence that coupled ripples between the MTL and

222 Our findings offer direct evidence that Cyp24a1 functions as an oncogene in

223 complexes in ded1 and dbp1 mutants provides direct evidence that Ded1 and Dbp1 cooperate to stimulat

224 aauw et al. (Cell 2019;176:729-742) provides direct evidence that disrupting systems regulating neuro

225 Altogether, our study provides direct evidence that endogenous Rspo2 and Rspo3 chromoso

226 These results provide the first direct evidence that ENSC transplantation can modulate t

227 In summary, our data provide direct evidence that EPCR plays a crucial role in regula

228 Here, we provide direct evidence that external biotic C sinks can limit p

229 In this study, we provide direct evidence that functional variants can alter trans

230 th fully integrated plastids, which provides direct evidence that genetic integration preceded organe

231 Here, we provide direct evidence that Hrd1 uses Ubc7 also for priming.

232 Chinese residential coal combustion provides direct evidence that intensive coal combustion could con

233 Nonetheless, direct evidence that Kac compromises mitochondrial perfo

234 Here, the authors provide the first direct evidence that KCNQ1 antibodies act as agonists on

235 This study presents the first direct evidence that Kir channels play a critical role i

236 Collectively, these data provide the first direct evidence that liver lymphatic drainage patterns f

237 These are the first direct evidence that LVAD support causes gastrointestina

238 We provide the first direct evidence that male rats, similar to humans, use b

239 Here we provide direct evidence that many people prefer coordinated puni

240 ly relevant genetic mouse models, we provide direct evidence that Men1 is essential for exocrine panc

241 These findings provide direct evidence that model-free and model-based learning

242 Together these data provide direct evidence that monocyte and macrophage transcripti

243 dies in mast cell-like RBL-2H3 cells provide direct evidence that Munc13-4 with its two Ca(2+)-bindin

244 Our findings provide direct evidence that nanoplastics can accumulate in plan

245 e selection tools in Fmr1-KO mice to provide direct evidence that normal functioning of the parvocell

246 These observations provide the first direct evidence that NPY signaling in the mPFC modulates

247 profiling with genetic screening, we provide direct evidence that oncogene-induced loss of progenitor

248 These experiments provide direct evidence that oxidase-derived ROS promotes the gr

249 Together, our results provide direct evidence that Piezo2 channels support mechanicall

250 to block consolidation, we report the first direct evidence that plasticity in somatosensory cortex

251 We provide for the first time direct evidence that platelet lamellipodium formation is

252 cent nucleosome pairs, our data also provide direct evidence that PRC2 can bridge pairs of distal nuc

253 These studies provide direct evidence that PRMT6 also deposits the H3R17me2a m

254 This study provides direct evidence that PSI confinements in synthetic lipid

255 ach to classifying RNA structure and provide direct evidence that RNA topology, in addition to sequen

256 Our investigations provide direct evidence that selective attention relies on rhyth

257 The data provide direct evidence that self-replication through secondary

258 These findings provide direct evidence that sex chromosomes can function throug

259 This provides the first direct evidence that shape features that accompany the p

260 Some satellites are transcribed, but we lack direct evidence that specific satellite RNAs are require

261 th bEnd.3 cells in a flow chamber, providing direct evidence that surface modification of nanoparticl

262 in generating avoidance behavior and provide direct evidence that synchronized oscillations play a ro

263 haromyces cerevisiae populations, we provide direct evidence that TE loads decrease rapidly under ase

264 We provide direct evidence that telomerase can add the nucleotide r

265 activity of the CES-like enzymes and provide direct evidence that the acyl-CoA synthetase ACS-7, whic

266 Findings from this study provide the first direct evidence that the connections between and among s

267 opean and Near Eastern ancestries, providing direct evidence that the Crusaders admixed with the loca

268 Together, this work provides the first direct evidence that the higher order chromatin structur

269 h a quartz crystal microbalance also provide direct evidence that the intercalation of the surfactant

270 Taken together, these results provide direct evidence that the IT cortex causally supports gen

271 etic approaches in mice to provide the first direct evidence that the nectin-afadin axis is essential

272 These data provide direct evidence that the profound loss of HCV-specific C

273 riments performed with purified Fpn provided direct evidence that the protease releases at least some

274 perturbed in rPPC1-B These findings provide direct evidence that the regulatory patterns of key guar

275 1 selects target mRNAs and provide the first direct evidence that the RNA binding functions of Bicc1

276 this in vitro Wnt acylation assay to provide direct evidence that the small molecule LGK974, which is

277 Overall, we provide the first direct evidence that the spread of a gene drive is hampe

278 This work provides direct evidence that the TOR signaling pathway in plants

279 Direct evidence that these chemistries are more generall

280 plicated in the maintenance of caveolae, but direct evidence that these lipids are required for norma

281 A by GlpQ reported here represents the first direct evidence that they are enantiomeric polymers: WTA

282 These findings provide direct evidence that TPCs can reversibly enter a quiesce

283 Our data thus provide direct evidence that translation is not required to main

284 of Calu-3 human airway cells, thus providing direct evidence that virus-Sia interactions may aid in v

285 A and IAV vRNA in infected cells and provide direct evidence that vRNA-associated Rab11A have altered

286 icular targeted probes, we provide the first direct evidence that Zn(2+) can be released from endolys

287 active redox mediator and provides the most direct evidence to date that MFT is a RiPP-derived redox

288 Our studies represent among the most direct evidence to date that tumor cells soften during c

289 search provides the first, to our knowledge, direct evidence to demonstrate that PCL proteins are cru

290 There is an urgent need for direct evidence to inform development of such interventi

291 Our data offer direct evidence to support a long-standing hypothesis th

292 There is currently no direct evidence to support that a migraine prophylactic

293 These findings offer direct evidence to support the applications of Au nanoca

294 Currently, there is a lack of direct evidence to support the hypothesis of disrupted m

295 of synaptosomes, our data provide the first direct evidence to support the idea that synapses from A

296 from land-based sources, but there is little direct evidence to support this assumption.

297 This work provides direct evidence to the understanding of irreversible mel

298 We also provide the first direct evidence, to our knowledge, of rotational diffusi

299 They also provide the first direct evidence using genetic lineage tracing for two ba

300 Direct evidence was obtained to corroborate the particle