ライフサイエンスコーパス: direct interaction

1 and concentration can serve as evidence of a direct interaction.

2 ells, recruited STIM1 to the junctions via a direct interaction.

3 s on Hsp90 and DnaK that are involved in the direct interaction.

4 co-stabilised at cell-cell contacts through direct interaction.

5 ation (CUE) domain in SMARCAD1 mediate their direct interaction.

6 he mPPCs disassemble Abeta fibrils through a direct interaction.

7 helicase activities of RECQL4 through their direct interaction.

8 nocopy each other exactly, consistent with a direct interaction.

9 Magnaporthe oryzae effector AVR-Pia through direct interaction.

10 gene expression by tuning MP output through direct interaction.

11 ) component, likely in a manner dependent on direct interaction.

12 ses, and uncovered that they form tripartite direct interactions.

13 properties in prostate cancer come from its direct interaction (1) with AR to affect androgen respon

14 bility that (i) these sites were involved in direct interaction and (ii) the residues in these sites

15 horylated STAT3 in a biphasic manner through direct interaction and deactivation of SHP2, thus blocki

16 ributes to FUS mislocalization through their direct interaction and nuclear export.

17 e reveal that seipin and GPAT3 associate via direct interaction and that seipin can simultaneously bi

18 udding Gag lattice, supporting a model where direct interactions and/or steric corralling between the

19 The interaction between PAI-1 and eNOS is a direct interaction as supported in experiments with puri

20 ity complex which is optimized by modulating direct interactions as well as dynamics, while toleratin

21 In tisB and other cases, a direct interaction between 30S subunits and a standby si

22 ture C-terminal domain (MCD), suggesting the direct interaction between AC domain and the MCD is requ

23 ur graphene wrapped approach circumvents the direct interaction between Ag array and the analytes, th

24 In this study, we identified a novel direct interaction between APP and the alpha2A-adrenergi

25 y of biophysical techniques did not detect a direct interaction between AX-024 and Nck-SH3.1 in vitro

26 Importantly, the direct interaction between BiP and Grp94 is nucleotide-s

27 s with pulldown experiments, we analyzed the direct interaction between CAIV and the two MCT chaperon

28 Isothermal titration calorimetry showed a direct interaction between calcium cations and both FPs.

29 Our results reveal a direct interaction between CD200L(+) endothelial cells a

30 This prevented the direct interaction between CD8(+) T cells and beta-cells

31 Furthermore, we demonstrated a direct interaction between circFOXP1 and miR-17-3p/miR-1

32 Evidence of a direct interaction between Clover-AZIN and antizyme-mRub

33 and one-hybrid assays, we find evidence for direct interaction between DAF-3 and the lag-2 promoter.

34 mass spectrometry data, indicates a possible direct interaction between DCT and CAV1.

35 We demonstrate a direct interaction between DEP and airway C-fiber affere

36 Here we report that a direct interaction between Dyn2 and the actin-bundling p

37 n and ELISA-style binding assays confirmed a direct interaction between EMILIN-1 and fibulin-4.

38 ysis following SCI revealed CD200L-dependent direct interaction between endothelial and local CD200R(

39 IL6R, and LDLR as modifiers of MMP9, with a direct interaction between ERG and MMP9.

40 a(i/o)-coupled GPCRs inhibit TRPM3 through a direct interaction between Gbetagamma subunits and TRPM3

41 til now we have been unable to demonstrate a direct interaction between gD and gH/gL.

42 il now, we have been unable to demonstrate a direct interaction between gD and gH/gL.

43 on, adding to previous findings indicating a direct interaction between gL and gB in EBV membrane fus

44 quivalent to that of HAdV-5, indicating that direct interaction between HAdV-5 and CAR is not require

45 Mechanistically, we have identified a direct interaction between Hippo and oestrogen receptor-

46 se results are consistent with a model where direct interaction between HmpF and the T4P system activ

47 een recently defined, most notably regarding direct interaction between Hsf1 and the constitutively e

48 bacteria and enteric viruses, we observed a direct interaction between influenza virus on the surfac

49 In addition, we observed a direct interaction between IQGAP1 and CaMKK2, which is m

50 The combined results indicate that the direct interaction between L1 and Reelin as well as the

51 using recombinant proteins, we verified the direct interaction between L1 and the nuclear binding pa

52 Here, we characterize the direct interaction between LARP4A, oligoA RNA and the ML

53 We detected direct interaction between LOXL2 and tropoelastin (TE) a

54 Lastly, we show a direct interaction between Med19 and Med1 by GST pulldow

55 We also discovered a direct interaction between mLST8 and the NH(2)-terminal

56 Our studies reveal that a direct interaction between NCT ectodomain and APP(C99) i

57 sts that by providing the means for fast and direct interaction between neurons, ephaptic modulation

58 In vitro studies revealed direct interaction between OGG1 and 8-oxoG containing DN

59 Here we demonstrate that direct interaction between P. gingivalis and S. cristatu

60 coiled-coil domain was also important for a direct interaction between p24delta5 and the GPI-anchore

61 n the biochemical reconstitution including a direct interaction between Rad51 and Dmc1 that is enhanc

62 ts that signal integration occurs through 1) direct interaction between receptors, 2) regulation of e

63 This direct interaction between RNA polymerase and ribosomes

64 These findings suggest that direct interaction between S1 and M1 may contribute to t

65 Direct interaction between Spire and Cappuccino is requi

66 Cell-based studies confirm that the direct interaction between TBK1 and STING is essential f

67 c-Src in same protein complex, as well as a direct interaction between the alpha1 subunit and c-Src.

68 biolayer interferometry and NMR indicated a direct interaction between the alphaMI domain, the major

69 uggest that allosteric modulation requires a direct interaction between the carboxyl group of alloste

70 ow open-state dependent rearrangement of the direct interaction between the eag domain and CNBHD, whi

71 into vacuoles, we also provide evidence for direct interaction between the LD surface protein (NoLDS

72 We pinpoint a direct interaction between the LNK SH2 domain and a phos

73 driver of synovial sarcoma) that mediates a direct interaction between the mSWI/SNF complex and the

74 cally, acute depletion of CTCF disrupted the direct interaction between the MYC promoter and its dist

75 ear magnetic resonance (NMR) data rule out a direct interaction between the NDSM and the K65 residue

76 that bound to HLA class II, and identified a direct interaction between the NK cell receptor NKp44 an

77 t compensatory mutagenesis data supporting a direct interaction between the RRM1 and RRM2 domains.

78 This identified a direct interaction between the Rrp9 beta-propeller domai

79 ore interfaces suggests a mechanism in which direct interaction between the sensor and the C-linker h

80 ro-apoptotic Bcl-2 family protein, through a direct interaction between the two proteins.

81 s, we identified the regions involved in the direct interaction between the yeast CAF-1 subunits, and

82 MREs prevented this decrease, demonstrating direct interaction between these miRNAs and TOP2alpha/17

83 ion of C/EBPalpha p42 requires site-specific direct interaction between TRIB2 and C/EBPalpha p42 for

84 Previous studies have demonstrated that the direct interaction between TRN-SR2 and HIV integrase pre

85 We demonstrate that a direct interaction between Ubp10 and the Sir2/4 sub-comp

86 We demonstrate a direct interaction between vancomycin and purified VanS(

87 The identification of the direct interaction between viral NP1 and host CPSF6 prov

88 In vitro experiments showed that direct interactions between actin filaments and lipid bi

89 Here, we report the first evidence of direct interactions between an aquatic mammal, the West

90 and in synapses, and evidence suggests that direct interactions between apoE and Abeta are important

91 lain the constituents of this community, and direct interactions between co-resident microorganisms h

92 Mechanistically, we uncover novel direct interactions between endogenous GPR124 and the Rh

93 Similar to the recent observation of direct interactions between enteric bacteria and enteric

94 nce approaches, we systematically tested for direct interactions between hERG1a and hERG1b subunits.

95 anism of repeat recognition for RIP involves direct interactions between homologous double-stranded D

96 be a consequence of regulated changes in the direct interactions between Hsp70 and Hsp90.

97 Further, we tested direct interactions between inner and outer photorecepto

98 flow throughout the entire pancreas suggests direct interactions between islet endocrine cells and su

99 Akt-membrane binding is mediated by direct interactions between its pleckstrin homology doma

100 Currently, there is no evidence of direct interactions between mosquitoes and marine mammal

101 dent m(6)A methylation status, together with direct interactions between MTA and TGH, influence the r

102 ings, and one order of magnitude higher than direct interactions between multiple lambs.

103 tight intermembrane space of ~3 nm, implying direct interactions between P2 and two membrane surfaces

104 Hence, for the first time, we uncover direct interactions between plastic nanoparticles and br

105 Direct interactions between proteins are essential for t

106 Coupling is thought to involve direct interactions between RNA polymerase (RNAP) and th

107 Proximity ligation assay revealed direct interactions between SNAP-25 and Gbetagamma subun

108 Direct interactions between the 2 proteins have been als

109 The data indicated that there are direct interactions between the alpha1 subunit and c-Src

110 in such confined channels(21) is affected by direct interactions between the channel walls and the hy

111 bsence of CTCF-mediated insulation, enabling direct interactions between the MYC promoter and a dista

112 y agglomerates at the ice surface, driven by direct interactions between the organic molecules.

113 tetherin, this antagonism is carried out via direct interactions between the transmembrane domains (T

114 ce that these functions are mediated through direct interactions between two key nodes of a posited "

115 ase activity of a UvrD dimer is promoted via direct interactions between UvrD subunits that affect th

116 This study identifies a functional, and direct, interaction between Dyn2 and a regulatory Rab GT

117 lfMRI allows the noninvasive measurement of directed interaction between brain regions and is capabl

118 Such a secretional division dictates directed interactions between the systemic circulation (

119 ons by not only aggregating information from direct interactions but also from second-order interacti

120 s reveal that MFN2 suppresses mTORC2 through direct interaction by binding its domain HR1.

121 substantial performance gains in estimating direct interactions compared to correlation analysis on

122 abilizing DNA binding to the octamer through direct interactions, core structural rearrangements, and

123 Through a direct interaction, Dot1l is recruited by Zc3h10 to the

124 Although ethanol targets BK channels through direct interaction, how ethanol-mediated BK channel acti

125 tochondria and lysosomes, allowing for their direct interaction in a pathway distinct from mitophagy

126 TAF4b protein that function to bridge their direct interaction in vitro Moreover, coimmunoprecipitat

127 translation is suppressed by LIN28B through direct interactions, independently of its role in regula

128 These direct interactions induce the formation of eosinophil e

129 howed similar group membership patterns, but direct interactions involving touch occurred at a rate t

130 Release of this direct interaction is ATP dependent, consistent with a t

131 we show by crosslinking experiments that the direct interaction is between a site in the middle domai

132 This direct interaction is mediated by the newly identified P

133 The direct interaction is mediated through the C-terminal ta

134 The direct interaction locks E148 in a conformation that doe

135 Based on these results, we hypothesized that direct interactions occur between the NTD and the CTD.

136 ntry into quiescence is a consequence of the direct interaction of (p)ppGpp and IF2.

137 that IL-15 induces LGC formation through the direct interaction of activated T cells and myeloid cell

138 onal activation and repression mechanisms by direct interaction of activator and repressor WOX genes

139 l proximity is often used as a proxy for the direct interaction of biomolecules.

140 Here, we study the direct interaction of Ca(2+) with phosphatidylinositol 4

141 to transmission of Plasmodium spp., and show direct interaction of CD11c(+) cells with infected hepat

142 This is enabled by the direct interaction of CD81 with the deoxynucleoside trip

143 Yeast two-hybrid assays established a direct interaction of Cep170 with AKAP350A.

144 Rather, CheY2 activity enhances the direct interaction of CheY2 with the adaptation protein

145 alation and metabolic studies pointed to the direct interaction of complex 1 with DNA and to the seve

146 pSRP54/ribosome binding interface revealed a direct interaction of cpSRP54 and the ribosomal subunit

147 distance-dependent phenomenon but requires a direct interaction of Cy3 with the protein, and the magn

148 Phosphorylation of this cluster promoted direct interaction of CYK4 with the BRCT repeat module o

149 biochemical analyses, we further document a direct interaction of E2A-PBX1, through a region spannin

150 In this report, we investigate a direct interaction of E4orf4 with the DDR.

151 Furthermore, we confirmed the direct interaction of FMRP with one candidate, RhoC, by

152 sfected COS-7 cells, strongly suggesting the direct interaction of GABA with AtALMT12.

153 This increase is potentially caused by the direct interaction of Gbeta proteins with a specific pat

154 inhibition can also be mediated through the direct interaction of Gbetagamma subunits with the solub

155 mSIRK to induce DA efflux, consistent with a direct interaction of Gbetagamma with the transporter.

156 Moreover, we detected no direct interaction of HIF-2alpha with YAP1.

157 ed nuclear magnetic resonance (NMR) revealed direct interaction of I942 and I178 with EPAC1 and EPAC2

158 promoting the T(H)2 response by IVIG through direct interaction of IgG with human basophils.

159 Direct interaction of Kindlin-2 with beta- and gamma-cat

160 differentiation events, review evidence for direct interaction of malaria-infected host cells with N

161 These findings reveal a broad direct interaction of mAtg8s with SNAREs with impact on

162 is a large scientific interest regarding the direct interaction of membrane-active peptides with whol

163 Direct interaction of meprin beta and ADAM proteases cou

164 We have shown a direct interaction of miR-181c with the 3' untranslated

165 tary approaches were used to demonstrate the direct interaction of MKK3 with MYC in vitro and in vivo

166 Our previous studies have shown that the direct interaction of netrin receptor DCC and DSCAM with

167 in vitro and in vivo studies indicated that direct interaction of p17 with hnRNP A1 maps within the

168 Using immunoprecipitation, a direct interaction of PGAM5 with the mitochondrial antiv

169 s in a single animal model, was based on the direct interaction of prion isolates with several recipi

170 Unlike type I rosetting that involves direct interaction of rosetting ligands on IRBC and rece

171 The direct interaction of Skap2 with the Wiskott-Aldrich syn

172 d that this effect probably occurs through a direct interaction of spermine with NspS, as purified Ns

173 DL/Orm-mediated regulation of SPT involves a direct interaction of sphingolipid with the membrane-bou

174 genous TDP-43 in cells, allowing to assume a direct interaction of TDP-43 with zinc ions.

175 We observe direct interaction of the bacterial cells with Al NPs an

176 This mitotic function is mediated by direct interaction of the central domain of ARHGEF17 wit

177 ntracellularly, therefore do not require the direct interaction of the cytotoxin with the organelle,

178 ributed to axon demyelination resulting from direct interaction of the M. leprae-specific phenolic gl

179 cation sites, which is dependent not only on direct interaction of the protein with the viral protein

180 Yeast two-hybrid experiments confirmed the direct interaction of these transcription factors.

181 These results exclude any direct interaction of this domain with the catecholamine

182 This was presumably the result of a direct interaction of TSPAN-7 and L-type Ca(V) channels

183 It has become increasingly evident that direct interactions of membrane proteins with their surr

184 In present study, we showed a direct interactions of p38, ERK or IkappaBalpha with MKP

185 n of Ser51 enhances binding to eIF2B through direct interactions of phosphate groups with residues in

186 adjacent to the plasma membrane, suggesting direct interactions of PIP(2) with these three regions.

187 shell or chemical contribution that includes direct interactions of the ion with nearby waters, 2) th

188 scopy maps and, for the first time, show the direct interactions of the p53 C-terminal with DNA.

189 s RNA nuclear retention, potentially through direct interactions of the SINE with KHDRBS1 and TRA2A,

190 transfer (FRET) assays, we now show the PBM directs interaction of p14 with GTP-Rab11.

191 dyl complexes are analysed considering their direct interaction or not with DNA as the cause of cell

192 Past work has focused primarily on direct interactions, particularly those between predator

193 e Purification (RAP-MS) identifies YBX1 as a direct interaction partner of lincNMR which regulates RR

194 the membrane protein caveolin -1 (Cav1) as a direct interaction partner of the GR.

195 family of merozoite surface proteins, as the direct interaction partner.

196 This direct interaction suggested that CHD7 may recruit histo

197 Rather than relying on a single direct interaction, the cooperation of multiple function

198 fied TOLLIP as a stabilizer of STING through direct interaction to prevent its degradation.

199 that it stabilizes such transcripts through direct interactions via the translational machinery.

200 over 6000 human proteins and more than 34000 directed interactions, we compared two states: normal/un

201 etween PvTRAg38 and basigin was confirmed by direct interaction where basigin was specifically recogn

202 r one phase) just balances the effect of the direct interactions, which cause it to prefer the other.

203 t modulating a transition metal center via a direct interaction with a Lewis acidic support can be a

204 to specific sites of action at enhancers by direct interaction with a transcription factor.

205 This direct interaction with actin suggests a new role of SPA

206 to bind actin, LYVE-1 displays little if any direct interaction with actin, as determined by co-immun

207 to the termination of lipid peroxidation by direct interaction with active groups of these lipids an

208 TRIB2 suppression is exerted via direct interaction with AKT a key signalling protein in

209 Stimulation of ATR activity requires direct interaction with an ATR activation domain (AAD)-c

210 it is recruited to distinct genomic loci by direct interaction with BRD4.

211 Lipid II in cellular membranes, implying the direct interaction with cell wall precursors is not the

212 Inactivation of AMT1;2 by direct interaction with CIPK23 requires kinase activity

213 onizes Not1 and promotes PB assembly via its direct interaction with Dhh1.

214 ene expression and which E1A overcomes via a direct interaction with E4orf3.

215 -regulate each other, they also cooperate by direct interaction with each during early oocyte develop

216 This occurs through direct interaction with Elongator and results in transcr

217 alleviates bleomycin-induced lung injury via direct interaction with extracellular histones.

218 nces global DNA methylation status through a direct interaction with folate status and (indirectly) w

219 ition of EBOV viral entry is mediated by the direct interaction with GP.

220 ranscriptional factor from ubiquitination by direct interaction with HSP90 chaperon and further speci

221 iR-210 regulated GPD1L protein level through direct interaction with its mRNA three prime untranslate

222 SPAN-7 controls beta-cell function through a direct interaction with L-type voltage-dependent Ca(2+)

223 t CotE enables binding of spores to mucus by direct interaction with mucin and contributes to its deg

224 led TLR complexes in DCs at steady state via direct interaction with MyD88 and PIP5K.

225 diated stripping of corona cargoes through a direct interaction with Nde1.

226 he PFV CBS is essential and sufficient for a direct interaction with nucleosomes and present a crysta

227 We reveal a direct interaction with PABP that is sufficient to promo

228 ch, by contacting collaborators, and through direct interaction with parents.

229 local customization, and time diverted from direct interaction with patients to computers.

230 identify a motif on DEPS-1 which mediates a direct interaction with PRG-1.

231 oplasmic location of this protein supports a direct interaction with regulators of gene transcription

232 RNA signals that modulate transcription via direct interaction with RNA polymerase (RNAP), we deep s

233 rOATP1A4 to the plasma membrane requires its direct interaction with rOATP1A1 resulting in a complex

234 been implicated to fulfil this role through direct interaction with rRNA and was identified in sever

235 Evidence is now provided of a direct interaction with Stt7 on the stromal side of the

236 -1946a modulates TGFbeta1 expression through direct interaction with TGFbeta1 3'UTR.

237 o the messenger RNA (mRNA) channel to form a direct interaction with the A-site codon to possibly int

238 olved an ability to enter host cells through direct interaction with the angiotensin converting enzym

239 otyrosine-binding domain of IRS-1 mediates a direct interaction with the C-terminal tail of IQGAP1.

240 n is stabilized by lysine 280, which makes a direct interaction with the carboxyl modification and th

241 strate that confinement at the nanoscale and direct interaction with the charged interfaces produce a

242 s in this pathway can be catalysed through a direct interaction with the copper chaperone for SOD1 (C

243 mic environments, and many behaviors include direct interaction with the environment itself.

244 s the farnesylated PDE6alpha subunit through direct interaction with the farnesyl moiety, mutations c

245 DRM1, is recruited to the proteasome through direct interaction with the large scaffolding protein RP

246 over operant responding for reward through a direct interaction with the mesolimbic DA system at the

247 es, such as migration and differentiation by direct interaction with the Neogenin (NEO1) receptor and

248 Both mRBPs regulate Nrf2 activity by direct interaction with the Nrf2 transcript.

249 targeted to microvilli in the absence of any direct interaction with the other IMAC components.

250 the expression of paired box (Pax)7 through direct interaction with the Pax7 promoter.

251 pore formation by a dual mechanism, i.e., by direct interaction with the peptide and by affecting mem

252 Their direct interaction with the pore-forming plasma membrane

253 on, retention, and stability occur through a direct interaction with the postsynaptic density-95/disc

254 1 replication but not Sabin-2 or Sabin-3 via direct interaction with the PV 5'UTR.

255 owever, Crabp1 can also compete with Ras for direct interaction with the RBD of Raf, thereby negative

256 y region 3 membrane protein RIDalpha via its direct interaction with the sterol-binding protein ORP1L

257 We determined that recruitment depended on a direct interaction with the synaptic protein Munc13, bec

258 ates T4P formation in its GTP-bound state by direct interaction with the tetratricopeptide repeat (TP

259 ponents of the core autophagic machinery via direct interaction with the ubiquitin-like proteins (UBL

260 s demonstrated that DIDS inhibited entry via direct interaction with the virion that impeded binding

261 lso activates the coagulation system through direct interaction with tissue factor (TF).

262 PC's protumorigenic function requires direct interaction with tumor cells and contributes to t

263 sphorylated at T505 by mTOR complex to allow direct interaction with USF-1 for recruitment to lipogen

264 and hydrophilic nicotine molecule showed no direct interactions with Abeta, nor did it affect Abeta

265 recruited in a gene-specific manner through direct interactions with activator-bound p300 that facil

266 In addition, proposed individual direct interactions with active zone proteins are insuff

267 ate the cell's unfolded protein response via direct interactions with amyloidogenic proteins.

268 stress response sigma factor, RpoS, through direct interactions with an activating seed sequence wit

269 4 (14-3-3Phi); GRF10 (14-3-3Epsilon)] showed direct interactions with AtPIP2;1 in the plant and upon

270 lies regulate exocytotic membrane fusion via direct interactions with Ca(2+) and phospholipid bilayer

271 zed substrate and as a soluble additive, via direct interactions with cell surface integrins alphavbe

272 be explained solely from the nature of their direct interactions with cellulose, but can be related t

273 s involved in the immune response, including direct interactions with chromatin, RNA and proteins.

274 demonstrated that cardiac neurons establish direct interactions with CMs, allowing neuro-cardiac com

275 ell understood, especially in the context of direct interactions with HCMV-infected cells.

276 239) residues on the S2 of the VSD that form direct interactions with Ile(135) on the HCND.

277 st-derived, secreted antimicrobials or force direct interactions with immune cells.

278 nd other signaling pathways via antagonistic direct interactions with key transcription factors.

279 We introduce matter , an R package for direct interactions with larger-than-memory datasets, st

280 posed to mosquito-vectored pathogens through direct interactions with mosquitoes.

281 We also show that direct interactions with nucleosomes are essential for O

282 These results support a mechanism in which direct interactions with phosphatidylinositol-containing

283 ying the inhibition of COP1 activity through direct interactions with photoactivated CRYs are not ful

284 (Glu(478), Gln(482), and His(559)) that form direct interactions with residues Arg(154) and Ser(158)

285 ty of IB-MECA toward A(3)R requires not only direct interactions with residues within the orthosteric

286 tically prepared in pure form, can engage in direct interactions with RNA resulting in mutual stabili

287 lish many of their diverse functions through direct interactions with RNA-binding proteins (RBPs).

288 the substrate-binding site are stabilized by direct interactions with SAPC and that the loss of such

289 eptors and receptor tyrosine kinases through direct interactions with small GTPases, including Rap1A

290 rol coupling and abundance of CaV2.1 through direct interactions with the CaV2.1 alpha1 subunit C-ter

291 re bound by only FXRalpha2 or FXRalpha4, via direct interactions with the DNA sequence motif ER-2.

292 ificant recruitment of a receptor that lacks direct interactions with the endocytic machinery.

293 ed the direction of gliding motility through direct interactions with the gliding motor.

294 a toxin 1 under lysogenic conditions through direct interactions with the stx1AB transcript.

295 2, whereas peptide selectivity is guided by direct interactions with the TCR CDR3 loops.

296 dominantly inhibited by cholesterol through direct interactions with the transmembrane domain.

297 pendent of membrane composition and involves direct interactions with transmembrane and periplasmic s

298 and regulate amino acid availability through direct interactions with tRNAs.

299 oth high and lower affinity contexts through direct interaction within a newly identified AR-interact

300 For simplicity and comparison with direct interactions within a network context, the conseq