ライフサイエンスコーパス: direct involvement

1 These results unambiguously show the direct involvement and promoting role of water in CO oxi

2 Supporting its direct involvement, biochemical analysis shows that A2BP

3 learned with PolioPlus, such as the value of direct involvement by local Rotarians, the program for e

4 s lacking V(1) subunits E or G, suggesting a direct involvement for these subunits in interaction of

5 ls in NLRP3 inflammasome assembly, but their direct involvement has not been shown.

6 recruitment to the SNR47 gene, suggesting a direct involvement in 3' end formation.

7 urons exposed to IFNgamma, implicating their direct involvement in ALS pathology.

8 used on identifying the residues that have a direct involvement in an enzymatic reaction, but these s

9 e self-antigen, raising the possibility of a direct involvement in antibody-mediated beta-cell dysfun

10 the 3' end of rgg, are necessary, either by direct involvement in binding or by indirectly affecting

11 not affect these interactions, suggesting no direct involvement in cargo loading/unloading.

12 f the high resolution WT structure, defining direct involvement in catalysis as well as in stabilizat

13 on of gK with virus-induced cell fusion, its direct involvement in cellular membrane fusion has been

14 ysical properties of cell membranes, but its direct involvement in cellular signaling has not been th

15 eric satellite DNA arrays rather than a more direct involvement in centromere structure.

16 Surprisingly, neither shows a direct involvement in chain association.

17 CBFbeta for wild-type AML1 function and its direct involvement in chromosomal translocation, we demo

18 However, rather than a direct involvement in DCV trafficking, this effect was a

19 esence of a marker allele, either because of direct involvement in disease etiology or because of LD

20 ge response system, although its exact role (direct involvement in DNA repair versus indirect, facili

21 nd/or its subunits have functions other than direct involvement in DNA repair.

22 served cysteine residues has suggested their direct involvement in hASBT function.

23 ng hotspot positions, and strongly support a direct involvement in hybrid infertility.

24 f total community), many of which had little direct involvement in metal or sulfate respiration.

25 recent studies have proposed that Myo2 has a direct involvement in mitochondria inheritance.

26 n the ubiquitin-proteasome system, but their direct involvement in muscle protein catabolism in cance

27 elial cells in injured muscle to suggest its direct involvement in muscle regeneration or angiogenesi

28 roles in metazoan embryonic development and direct involvement in numerous disease states.

29 meostasis after ovarian events, instead of a direct involvement in ovarian functions.

30 ically devoted to the ICU for the purpose of direct involvement in patient care.

31 chia coli L2, which has been implicated in a direct involvement in peptidyl transferase activity.

32 ing, with embodied theories supporting their direct involvement in processing verbs describing body p

33 ep of transcription initiation factor IIIB's direct involvement in promoter opening.

34 ue and cancer in various organs, without any direct involvement in promoting fibroblast recruitment a

35 ng Kunitz and endostatin domains, suggesting direct involvement in protease inhibition and axonal mig

36 hts into the function of hTFIIIC and suggest direct involvement in recruitment of both TFIIIB and RNA

37 ymatic activity of Them2 suggests additional direct involvement in regulating hepatic nutrient homeos

38 ons of concentrated actomyosin, suggesting a direct involvement in regulation of local cell adhesion.

39 To date, their direct involvement in retinal innate defense against bac

40 (PQBP1) is of particular interest due to its direct involvement in several X chromosome-linked intell

41 been linked to MAPK activation suggesting a direct involvement in signaling cascades.

42 liceosome and some pre-mRNAs, suggesting its direct involvement in specific splicing events.

43 tion in developing pollen, indicative of its direct involvement in specification of aperture position

44 s near the subunit interface rules out their direct involvement in subunit association but leaves ope

45 stem lost this resistance, demonstrating its direct involvement in survival under these conditions.

46 ases, case commentaries from authors without direct involvement in the case, publications before 2014

47 flexible nature of Glu165, which favors its direct involvement in the formation of the enediol inter

48 unctions, but there is little evidence for a direct involvement in the junctional permeability barrie

49 ugh 34 d after infection, nor do they have a direct involvement in the maintenance of HSV-1 latency.

50 ld interact directly with Msk, suggest their direct involvement in the nuclear import of MAD.

51 pathway initiated by exogenous FGF-1 by its direct involvement in the nuclear transport and signalin

52 bstrate specificity and strongly suggest its direct involvement in the recognition of and binding to

53 armaceutical industry drug target due to its direct involvement in the regulation of food intake and

54 t Fob1p is a nucleolar protein, suggesting a direct involvement in the replication fork block.

55 dentification of human fluids suggests their direct involvement in these rituals.

56 conformational change is unlikely to have a direct involvement in toxicity.

57 in/CTTN is considered a likely candidate for direct involvement in tumor progression because of its c

58 n, and intestinal colonization; however, its direct involvement in virulence has not been reported.

59 social defeat, observing aggression without direct involvement, is less studied but has growing rele

60 h strong aliphatic C-H bonds, indicating the direct involvement of 3 in the oxidation/chlorination re

61 These findings demonstrate the direct involvement of 4EHP in virus-induced host respons

62 These studies had strongly suggested direct involvement of a flexible paratope in the observe

63 ese data provide additional evidence for the direct involvement of a metal-coordinated sulfur nucleop

64 is is the first report that demonstrates the direct involvement of a regulatory protein (SarA) in con

65 study we provide the first evidence for the direct involvement of a specific NK killer receptor in p

66 Thus, this report represents direct involvement of a viral small noncoding RNA in vir

67 simple technique support the contention of a direct involvement of a vitamin D-induced calcium-bindin

68 in neurons, are predominantly known for the direct involvement of a-synuclein in the etiology and pa

69 lthough this limited experience did not show direct involvement of abdominal fluid and omentum, asses

70 While the direct involvement of Abeta in AD has been well document

71 xt used optogenetic silencing to confirm the direct involvement of abGCs in context encoding and disc

72 Its biological effects may be due to direct involvement of ADM receptors, but also to activat

73 tor restored glycogen stores, confirming the direct involvement of Akt/GSK-3beta signaling.

74 Our findings demonstrate the direct involvement of an extracellular matrix protein as

75 ently bound to the ATF4 promoter, suggesting direct involvement of an mTORC1/c-MYC-driven signaling p

76 by light exposure raises the question of the direct involvement of AP-1 in mediating photoreceptor ce

77 Our findings indicate a direct involvement of aPKC in Hh signaling beyond its ro

78 These findings show direct involvement of Arps in the chromatin-remodeling p

79 ded a wealth of data that largely supports a direct involvement of astrocytes on diverse aspects of b

80 result provides a possible mechanism for the direct involvement of ATM in non-homologous end joining-

81 lding by Hsp90 is poorly understood, and the direct involvement of ATP has been particularly contenti

82 This direct involvement of Aurora B in SAC signaling may main

83 gns of antibody maturation are indicative of direct involvement of B cells in local inflammatory proc

84 These results suggest the direct involvement of B cells in tolerance to p1-102 epi

85 These findings support a direct involvement of basophils in inflammation as well

86 Direct involvement of C1INH in modulation of selectin-me

87 k of this current by nifedipine suggests the direct involvement of Ca(v)1.3 Ca(2+) channels in its ac

88 doptive transfer experiment, we assessed the direct involvement of CCR2 and CCR6 in the recruitment o

89 l tissues is a complex process requiring the direct involvement of cells derived from pluripotent ste

90 from lack of cell movement rather than from direct involvement of ciliary assembly pathway component

91 Mouse models support a possible direct involvement of CK in asthma protection via inhibi

92 esults provide experimental evidence for the direct involvement of conditionally disordered regions i

93 identification and action planning; and the direct involvement of consultant obstetricians and anaes

94 o the most compelling pieces of evidence for direct involvement of cortical signals in perception com

95 Overall, our study highlights the direct involvement of CS integrity in modulating Ca-depe

96 Although there is robust evidence for the direct involvement of Cx26 in cochlear functions, the co

97 h Arg-122 at the active site of CN, implying direct involvement of CyPA-CsA in the regulation of CN c

98 nd individual human cathepsins demonstrate a direct involvement of cysteine cathepsin B (CtsB) and L

99 The direct involvement of Dbp3p in ribosomal biogenesis is s

100 rovide first experimental evidence showing a direct involvement of DeltaDNMT3B4 in regulating RASSF1A

101 To test a direct involvement of Dicer1 phosphorylation in tumor de

102 Our findings provide evidence for the direct involvement of DNA Pol lambda in the repair of DS

103 is the first experimental PET study to show direct involvement of dopamine in the vmPFC in a task-sw

104 n and disease is gaining wider acceptance, a direct involvement of effector CD4(+) T cells in this pr

105 studies of individual genes have revealed a direct involvement of epigenetic factors in alternative

106 These observations suggest a direct involvement of Era in the assembly and maturation

107 Motif analyses revealed a lack of direct involvement of estrogen receptors or the androgen

108 However, no evidence for direct involvement of FIS in tRNA1Leu expression has bee

109 Short range functions include: (a) direct involvement of five amino acids in Ca2+ binding w

110 an FK506 non-producing mutant demonstrating direct involvement of fkbA in the biosynthesis of FK506.

111 In this study we report on direct involvement of fluid shear stresses on the osteob

112 In addition, direct involvement of Fur in the regulation of DNA synth

113 ibited Raf-1 and ERK1 activity, indicating a direct involvement of G betagamma subunits in the signal

114 tion early after transplantation, suggesting direct involvement of gammadelta T cells in anti-CMV imm

115 neuron autonomous event facilitated without direct involvement of glial cells.

116 protein signaling that operates without the direct involvement of GPCRs.

117 The direct involvement of Gq/11/phospholipase C signaling an

118 These results implied the direct involvement of graft-derived interneurons in seiz

119 No evidence for direct involvement of GSH in the induction of assembly w

120 The direct involvement of GTP for the phosphorylation of Env

121 Direct involvement of His(229) in the reaction mechanism

122 nd three other lines of evidence support the direct involvement of HisZ in the transferase function.

123 e disequilibrium with a disease locus or the direct involvement of HLA alleles in RA.

124 aken together, these results demonstrate the direct involvement of hMR in HIV-1 infection of astrocyt

125 ts of Ad-HO-1 gene transfer, documenting the direct involvement of HO-1 in protection against I/R inj

126 ated with the functional complex, implying a direct involvement of Hsp90 in telomere length regulatio

127 These observations reveal a novel direct involvement of human PABP in the stabilization of

128 in cleavages have been observed in which the direct involvement of ICE-like proteases has been postul

129 PAC-IUBMB-IUPAB inter-union venture with the direct involvement of ICSU and CODATA.

130 The direct involvement of IGFBP-3 in cell growth inhibition

131 jection in atopic hosts does not require the direct involvement of infiltrating eosinophils.

132 ting effects to those of insulin, suggesting direct involvement of insulin in transformation.

133 lls bearing KDR CNGs, providing evidence for direct involvement of KDR.

134 The present study provides evidence for a direct involvement of kinase suppressor of Ras 2 (KSR2)

135 Here we report the direct involvement of KU80, a protein that binds dsT-DNA

136 ine (DA) release, while the possibility of a direct involvement of L-dopa itself in LID has been larg

137 r results present definitive evidence of the direct involvement of LCRs in 22q11 deletions and map bo

138 replication sequences may further suggest a direct involvement of left-end replication sequences in

139 Furthermore, direct involvement of lipid metabolism in the pathogenes

140 ing AUGC sequences of the viral RNA, without direct involvement of loop nucleotides.

141 , Brk may regulate other Dpp targets without direct involvement of Mad.

142 ed the cytotoxicity of ara-C, suggesting the direct involvement of MAPK as a downstream antiapoptotic

143 evidence for linkage disequilibrium and the direct involvement of markers DR4 Dw4, DR4 Dw14, and DR1

144 Findings provide support for direct involvement of maternal hyperandrogenemia in ASD

145 enzymes can affect O(2) reactivity without a direct involvement of metal cofactors.

146 radical cation decay is achieved through the direct involvement of methanol in the deprotonation of t

147 Further, pathway analysis suggested direct involvement of miRNA-29a/b in downregulating the

148 s on the latest progress made in the area of direct involvement of miRNAs in signaling, translocation

149 Direct involvement of mitochondrial ROS in intestinal tu

150 MLH1 gene was reintroduced, demonstrating a direct involvement of MMR proteins in sensitivity to the

151 -apo riboflavin-binding protein, we show the direct involvement of molecular oxygen and DNA base-drug

152 provides a means to oxidize proteins without direct involvement of more potent oxidants.

153 e results demonstrate for the first time the direct involvement of MOSC2 and CYB5B in the amidoxime r

154 However, controversies about the direct involvement of MSCs in tumor progression suggest

155 ese data, both in vitro and in vivo, suggest direct involvement of MSH2 in processing IdUrd in DNA.

156 thermore, recent studies have demonstrated a direct involvement of mTOR signaling in regulating HSF1-

157 ese abnormal characteristics, indicating the direct involvement of N-glycosylation events in these ph

158 To examine the direct involvement of NAD(P)H oxidases in Ang II-induced

159 These data provide new evidence for direct involvement of neurogenesis in the etiology of de

160 vely, our results demonstrate a physical and direct involvement of NF-kappaB in alternative splicing

161 28 stimulation in T-cells, which implies the direct involvement of NFAT in mediating the CD28 stimula

162 lls and virus-infected cells, highlighting a direct involvement of NP1 in viral DNA replication at Or

163 ntly, this represents the first evidence for direct involvement of one two-component system in transc

164 hese results provide strong evidence for the direct involvement of organometallic Ni(III) species in

165 The direct involvement of p38 pathways in cardiac hypertroph

166 ality patient-centered care will require the direct involvement of patients and medical professionals

167 Direct involvement of PKC in the regulation of ODC by ox

168 , as shown by immunoprecipitation, indicated direct involvement of PKCs in Bad phosphorylation.

169 This study establishes a direct involvement of plasminogen in monocyte recruitmen

170 However, the direct involvement of poly ADP-ribosylation was also app

171 Demonstration of the direct involvement of primary tumor stroma in metastasis

172 ion across the channel, which occurs without direct involvement of protein hydrophilic residues.

173 These results are consistent with the direct involvement of proteoglycans in transfection.

174 To examine the possible direct involvement of PSA in the interactions between PC

175 e of adjacent subunits can be sensed without direct involvement of R-finger residues.

176 Our findings provide support for the direct involvement of RAG2 in DNA binding during all ste

177 The direct involvement of RAR beta in atRA-induced STAT1 gen

178 ay can be caused by two separate mechanisms: direct involvement of RDH8 and ABCA4 in cone chromophore

179 The direct involvement of reactive oxygen in the kinetically

180 experiments in the presence of 6-AHA reveal direct involvement of residues Tyr36, Trp62, Phe64, and

181 However, the direct involvement of REV-ERBs in these effects of SR900

182 rom that used by mice, possibly reflecting a direct involvement of rodents and not humans in the para

183 ory area, and causal perturbation suggests a direct involvement of S1 decision neurons in the decisio

184 ations via amino acid substitutions and/or a direct involvement of S6 C-termini in Na(+) channel gati

185 This study shows the direct involvement of sacsin domains in regulating inter

186 ATP and was abolished by BHQ, indicating the direct involvement of SERCA.

187 ence from human translocations regarding the direct involvement of SNRPN in the pathogenesis of PWS a

188 signal independently of Notch, indicating a direct involvement of somatic myosin activity in axis fo

189 We report here the molecular basis for the direct involvement of Spi-1 in HCMV activation of il1b.

190 r knowledge, this is the first report of the direct involvement of surface-expressed enolase in the p

191 e mutants leave open the question concerning direct involvement of T1 in gating.

192 he proteinase K treatment, demonstrating the direct involvement of T2SS in translocation of MtrC and

193 These findings, which suggest a direct involvement of tau in axonal transport, have impl

194 limits clonal burst (P = 0.0001) revealing a direct involvement of telomerase in T cell fate decision

195 These data provide further evidence for direct involvement of the aberrant T-cell populations in

196 Our results point to direct involvement of the AChR molecule in restricting r

197 vent formation of the fVIII.vWf complex, the direct involvement of the acidic region in this binding

198 Together, these results suggest a direct involvement of the alpha 5 subunit in the observe

199 compared with WT controls, corroborating the direct involvement of the alpha4-subunit in high-affinit

200 The direct involvement of the BMP/Smad pathway in this induc

201 o the rate accelerations with added bases is direct involvement of the buffer base in either atom-pro

202 interactions prevent processing, whereas the direct involvement of the C-terminal region in processin

203 Our results support direct involvement of the cerebellum in RL-PE processing

204 esigned neuroserpin mutants to demonstrate a direct involvement of the conserved 14-mer region in its

205 This work reports the direct involvement of the ESCRT machinery in the life cy

206 of pathogens via the bloodstream can lead to direct involvement of the eye.

207 ts pivotal role in bitter taste sensation, a direct involvement of the G-protein subunit alpha-gustdu

208 primarily of carbohydrate, with probably no direct involvement of the gp120 polypeptide surface.

209 Overall, our data reveal the direct involvement of the gut microbiota in trastuzumab

210 Direct involvement of the heparan sulphate glycosaminogl

211 ore protein during infection and support the direct involvement of the HLA-DRB1 gene in vaccine nonre

212 These findings reveal a direct involvement of the Ig light chain (IgL) in B cell

213 ely, these findings provide evidence for the direct involvement of the IL-2/IL-2R signaling pathway i

214 studies revealed that the answer is not the direct involvement of the Lewis base catalyst, but rathe

215 ith GHRPYam, the packing of which showed the direct involvement of the ligand tyrosines in antiparall

216 Direct involvement of the lower gastrointestinal tract c

217 catalysis-dependent changes, suggesting the direct involvement of the metal ion in catalysis.

218 transition state of methyl transfer shows a direct involvement of the METTL3 side chains E481 and K5

219 These observations imply direct involvement of the mismatch repair system in the

220 These data suggest a direct involvement of the mutated amino acid in metal io

221 Direct involvement of the N-terminal domains in the bind

222 sent the first experimental evidence for the direct involvement of the NisB protein in the maturation

223 These properties are a result of the direct involvement of the nuclear localization sequences

224 es weakly with mutated proteins, exclude the direct involvement of the polyalanine tract in dimer for

225 lu781-->Lys substitution seemingly precludes direct involvement of the residue in the cation binding

226 A modification enzymes and the potential for direct involvement of the RNA substrate in controlling t

227 The measurements focus on the direct involvement of the sole W residue in the nucleic

228 roposed mechanism, these results support the direct involvement of the substrate in O(2) activation b

229 ce energy transfer assays, we demonstrated a direct involvement of the survivin baculovirus IAP repea

230 Direct involvement of the Sxl glycine-rich region in pro

231 cytochrome oxidase subunit IV, indicating a direct involvement of the TbTim17 in the import process.

232 A direct involvement of the TRN in SZ and BD has not been

233 The direct involvement of the two pathways was further estab

234 These findings offer strong evidence for the direct involvement of the type A domain in C3b binding,

235 ly with this deleterious phenomenon, but the direct involvement of these inflammatory cells has not b

236 Such activity losses are consistent with the direct involvement of these latter two residues in the p

237 d by clonally expanded T cells, suggesting a direct involvement of these lymphocytes in plaque disrup

238 nsPs, which suggested to us that there is a direct involvement of these proteins in promoter recogni

239 se joints, consistent with studies showing a direct involvement of this cytokine in CD28 gene transcr

240 ed cell invasion and migration, indicating a direct involvement of this enzyme in cell locomotion.

241 ion of E2Fs has thus been unclear; moreover, direct involvement of this gene in primary human tumorig

242 promoting ovarian tumors and thus supports a direct involvement of this gene in the commencement of o

243 ells in the absence of ligand, verifying the direct involvement of this polypeptide in the regulation

244 no evidence was obtained to demonstrate the direct involvement of this protein in cobamide biosynthe

245 ximal to the affected telomere, suggesting a direct involvement of this protein in telomere maintenan

246 In this study, we investigated the direct involvement of TLR2 and TLR4 in MAM binding and p

247 lls stably expressing mouse TLR9, suggesting direct involvement of TLR9 in the recognition of RpG mot

248 rounded by DiI-labeled TBMCs, suggesting the direct involvement of transplanted TBMCs in myocardial c

249 In the current work, we investigated the direct involvement of two major prefrontal subregions, t

250 uctural and biochemical data demonstrate the direct involvement of two metal ions in catalysis, and s

251 The direct involvement of ubiquitylation in caspase activati

252 w audiences through two different approaches-direct involvement of undergraduates in discovering and

253 ansition state structure that implicates the direct involvement of unmodified G2922 in Nog2 GTPase ac

254 ese results provide further evidence for the direct involvement of v-Src in tyrosine phosphorylation

255 t the observed cell death is the result of a direct involvement of VEGFA in chondrocyte survival.

256 ion, nifedipine or Bay K 8644, excluding the direct involvement of voltage-gated Ca(2+) channels in I

257 Several of the novel associations implicate direct involvement of, or interaction with, genes previo

258 , we manipulated glycolysis and assessed its direct involvement on V-ATPase function.

259 chromosome 12q24.13, was cloned through its direct involvement with MYC and IGH in a three-way trans

260 LCH is broadly divided into two categories: direct involvement with the disease (e.g., lytic lesions

261 asmic tail of retina insulin receptor showed direct involvement with the p85 subunit of PI3K in vitro