ライフサイエンスコーパス: direct regulation

1 EP gene promoter region in vitro, indicating direct regulation.

2 were downregulated in HNF4A -KO, suggesting direct regulation.

3 Direct regulation, altering the informational environmen

4 with low druggability have multiple positive direct regulations and positive feedback loops.

5 ns have proven to be effective tools for the directed regulation and modification of genes.

6 The main function of the sigma(E)-directed regulation appears to be to coordinate sigma(G)

7 e reactions that currently lack evidence for direct regulation as (putative) indirectly regulated (~9

8 his feedback loop is at least in part due to direct regulation, as assessed by in vivo and in vitro b

9 inS, supporting bioinformatic predictions of direct regulation at both promoters.

10 By contrast, few enzyme-encoding genes (direct regulation) but many ribosomal protein- and tRNA-

11 dermal explants culture system, suggesting a direct regulation by 1,25(OH)(2)D(3).

12 aining AGL15 binding sites as candidates for direct regulation by AGL15.

13 creased expression of c-Myc, evidently under direct regulation by AP-1 through a conserved distal 3'

14 These genes respond transcriptionally to direct regulation by both the proneural proteins and the

15 BDCA-RNAIII promoter region, suggesting that direct regulation by CodY is unlikely to be the principa

16 Direct regulation by CovR was suggested by the presence

17 et of those genes, suggesting their possible direct regulation by Ctip2.

18 trameric but not dimeric GLUT1 is subject to direct regulation by cytosolic ATP and that this regulat

19 for some putative target genes support their direct regulation by Gli.

20 s rapidly induced upon sugar feeding through direct regulation by Mondo-Mlx.

21 ing and genomic sequences of Tead2 suggested direct regulation by MyoD, and consistent with this, Myo

22 Consistent with direct regulation by NMD, representative upregulated tra

23 teins identified were known to be subject to direct regulation by PrfA, the majority have not previou

24 a subset of these genes (n = 30), suggesting direct regulation by SigH.

25 e by employing mechanisms within and without direct regulation by the ER.

26 ells at the animal pole, which are not under direct regulation by the Nodal pathway, behave normal in

27 estored regulation, confirming that there is direct regulation by the sRNA.

28 liverwort Marchantia paleacea to AMF and its direct regulation by the transcription factor WRINKLED (

29 miR-122 bound HNF6 in vivo, confirming their direct regulation by this factor.

30 nalysis because such data cannot distinguish direct regulation by transcription factor binding from i

31 these genes, YDR492w and YOL002c, suggested direct regulation by Zap1p, whereas the expression of YO

32 rmination, and biological functions of miRNA-directed regulation have been reported for four of 15 kn

33 direct protein-protein contact and that this direct regulation is primarily responsible for the crypt

34 owing that gene expressions are often due to directed regulations, it is more meaningful to estimate

35 Direct regulation of 149 DEGs was suggested by strong pr

36 tes neuronal migration in the cortex through direct regulation of a second Rnd family member, Rnd3.

37 Small RNA regulatory circuits involve direct regulation of a small RNA by a TF and/or direct r

38 ect regulation of a small RNA by a TF and/or direct regulation of a TF by a small RNA and have been s

39 culum stress susceptibility, in part through direct regulation of activating transcription factor 4 (

40 thus reveals a critical role of a TLR in the direct regulation of adaptive immune response and pathog

41 beige adipocyte properties and that KLF15's direct regulation of Adrb1 is a critical molecular mecha

42 gulation of B cell GC reactions that include direct regulation of AICDA and BCL6.

43 er P-AKT(T308), highlighting a prominent and direct regulation of AKT by mTORC2 in cancer cells.

44 owledge gap in the mechanisms underlying the direct regulation of angiogenesis by nerves.

45 poptotic response to HDAC inhibitors through direct regulation of APAF1.

46 This direct regulation of APC/C by lactate stimulates timed d

47 We found no evidence for direct regulation of ARAP3's Rho GAP activity by PtdIns(

48 ion factor E2F-3 altered glutamine uptake by direct regulation of ASCT2 mRNA and protein expression,

49 ors during later development may involve the direct regulation of axon extension by target neurons.

50 s can be explained, at least in part, by the direct regulation of B-cell function.

51 The data suggest that direct regulation of beta-catenin-LEF/TCF signaling is o

52 and antagonizes canonical Wnt signaling via direct regulation of beta-catenin.

53 on of the erythroid lineage, associated with direct regulation of beta-globin expression.

54 Thus, direct regulation of BIRC3 by GR and BIRC3/BIRC2 by NF-k

55 f MDA-MB-231 cells is mediated by PLD2 under direct regulation of both JAK3 and the tyrosine kinase,

56 deletion of Utx in the skin, we demonstrate direct regulation of both retinoid metabolic genes such

57 function, namely membrane translocation and direct regulation of Btk catalytic activity.

58 in-1-dependent transcription, likely through direct regulation of c-Jun activity.

59 catalytic domain and providing the means for direct regulation of catalytic activity in response to e

60 tudies demonstrate a novel mechanism for the direct regulation of CD4(+) T cells by M. tuberculosis l

61 s involved in prostate cancer metastasis via direct regulation of CD44, a ubiquitous marker of PCa tu

62 tosis is mediated, at least in part, through direct regulation of Cdc25C.

63 mitosis is at least partly mediated through direct regulation of Cdc25C.

64 can influence cell cycle progression through direct regulation of cell cycle proteins, through nutrie

65 tes cellular proliferation and apoptosis via direct regulation of cellular gene expression.

66 composition of target condensates, enabling direct regulation of cellular processes in condensatopat

67 re known to occur in vivo) and a pathway for direct regulation of cholesterol biosynthesis by bile ac

68 domain, providing support for a specific and direct regulation of CHT by APP through protein-protein

69 This direct regulation of CK2 by a cell surface receptor prov

70 ighting the importance of this interface for direct regulation of CLOCK:BMAL1 activity by CRY1.

71 The direct regulation of COL5A1 by miR-185 and miR-186 was c

72 However, direct regulation of collagen matrix by CRT has not been

73 Thus, direct regulation of complex I by mitochondrial MEF2D un

74 nd invasion and increases CAM-DR through the direct regulation of CXCR4 and FAK expression and FAK/PI

75 nd western blotting analyses, we confirm the direct regulation of CYGB by DeltaNp63alpha.

76 and gain-of-function studies further support direct regulation of dAP-2 by Hox proteins and suggest t

77 lterations in synaptic activity, rather than direct regulation of DCV release.

78 lammation and psoriasis pathogenesis via the direct regulation of dermal IL-17-producing cells and st

79 However, the direct regulation of differentiation-inducing hematopoie

80 the Dll1 transcription start site suggesting direct regulation of Dll1 by GATA4.

81 Thus, direct regulation of DNA methylation can prevent/reverse

82 eal a novel function of CRL4(Cdt2), i.e. the direct regulation of DNA polymerase delta, adding to its

83 Thus, E2A-HLF could transform cells by direct regulation of downstream target genes, acting thr

84 nents to the promoter, thus facilitating the direct regulation of E75A gene expression by JH.

85 We showed direct regulation of ENDOG by ERR-alpha and PGC1alpha (w

86 CPS also seems to provide a novel example of direct regulation of enzymatic activity in hormone biosy

87 Notch activity mediates CTL activity through direct regulation of EOMES, perforin, and granzyme B.

88 with many epithelial genes, suggesting that direct regulation of epithelial identity may be a conser

89 the intrinsic ligand, explaining the lack of direct regulation of ERG channels by cyclic nucleotides.

90 However, little evidence exists for direct regulation of extracellular diffusion by the ECM

91 gulation of the vicRKX operon or substantive direct regulation of fatty acid biosynthesis by VicR or

92 ese findings identify the first evidence for direct regulation of FLNa, implicating a mechanism where

93 te its importance, little is known about the direct regulation of Foxn1 expression.

94 is the first demonstration of GATA and RUNX direct regulation of Friend of GATA gene expression and

95 We explored the direct regulation of G-protein signaling by RLKs using p

96 ansmission could be fully accounted for by a direct regulation of GABA release by kainate receptors l

97 Although direct regulation of GIRKs by the heterotrimeric G-prote

98 ted in response to JQ1 treatment, supporting direct regulation of GLI activity by BRD4.

99 d that AHL10 maintains redox homeostasis via direct regulation of glutathione transferase (GST) genes

100 ntary mechanisms that extend well beyond the direct regulation of heme biosynthesis and degradation.

101 through modulation of serum ADMA levels via direct regulation of hepatic DDAH1 gene expression.

102 ether this inhibitory action of GH is due to direct regulation of hepatic lipid metabolism.

103 owever, whether ERalpha is implicated in the direct regulation of HIF-1alpha and the role of HIF-1alp

104 In addition to the direct regulation of HLA-DRalpha, RTA can also indirectl

105 s, but whether these effects are mediated by direct regulation of host immunity or indirectly through

106 e the HSP-27 promoter, supporting a role for direct regulation of HSP-27 expression.

107 ates gammadeltaT17 effector function through direct regulation of IDH2 promoter activity.

108 or the first time, specific miRNAs under the direct regulation of IGF-1 signaling in the estrogen rec

109 ogenic microRNAs (miRNAs) that are under the direct regulation of IGF-1 signaling.

110 n-dependent behavioral avoidance rather than direct regulation of innate immunity.

111 These findings indicate that direct regulation of IP3R by NADH is responsible for ele

112 eotide-binding protein, but the mechanism of direct regulation of its GTPase activity remains unclear

113 increased sOb-R expression and release via a direct regulation of its promoter, while CHOP deletion r

114 tin immunoprecipitation and promoter assay a direct regulation of its transcription by RUNX1.

115 The direct regulation of key cell cycle regulators by the di

116 integration of environmental inputs and the direct regulation of key clock genes.

117 These results strongly support the direct regulation of Kv7 channels by PIP2 and its deplet

118 upstream of the mouse Lasp2 gene suggesting direct regulation of Lasp2 by PXR.

119 xpression of dAP-2 and provides evidence for direct regulation of leg segmentation by regional combin

120 oses the "default" cDC fate, in part through direct regulation of lineage-specific gene expression pr

121 Our study is the first to validate direct regulation of LOX and LOXL2 by the miR-200/ZEB1 a

122 ion of leukocytes; however, their intrinsic, direct regulation of lymphocyte fate remained unclear.

123 ntial role of these lipid mediators (LMs) in direct regulation of lymphocyte functions.

124 l crest development, but have not identified direct regulation of melanocyte development by GDF6.

125 zymes(3-5), it is not known whether there is direct regulation of metabolic enzymes.

126 ChIP assays showed the direct regulation of miR-200b by CAGE.

127 rial abnormalities resulted from the loss of direct regulation of mitochondrial proteins by calpain-3

128 l mediator of vascular SMC proliferation via direct regulation of mitotic progression.

129 ly unappreciated mechanisms of Snai1 for the direct regulation of MMPs during EC development.

130 pically associated with cell growth, but not direct regulation of motility or polarity.

131 role of Cnn (or its related) proteins in the direct regulation of MT assembly and organization of non

132 knowledge, this is the first report to show direct regulation of MT1-MMP by HIF-2 and to provide a d

133 manner through a mechanism that includes the direct regulation of multiple effector T(H)17-associated

134 d protein kinase signaling pathway and/or by direct regulation of multiple metabolic pathways.

135 Our results provide evidence of direct regulation of Mxi1 by FOXO3a and imply an additio

136 effects on plant growth and development and direct regulation of N metabolism-related genes.

137 In addition to a major role in the direct regulation of NAD homeostasis, some members of Nr

138 lay multiple roles in the CNS, including the direct regulation of neuronal and astrocytic functions.

139 These results identify a novel way for direct regulation of NF-kappaB activity in diverse cell

140 Our results report a direct regulation of Nurr1 by CREB after NMDAR stimulati

141 metabolic tissues, providing a framework for direct regulation of nutrient metabolism.

142 fects on cellular metabolism, through either direct regulation of nutrient transporters and metabolic

143 lation of eNOS at Ser-1177 is pivotal in the direct regulation of O(2)* and NO generation, altering b

144 ols ESC pluripotency and differentiation via direct regulation of Oct4 gene expression.

145 XA10 subsequently supports bone formation by direct regulation of osteoblast phenotypic genes.

146 (+/-)) increased bone resorption, suggesting direct regulation of osteoclast (OC) activity by the Hh

147 oblastic/osteoclastic cross-talk through the direct regulation of osteoprotegerin (OPG).

148 l to exhibit complementarity or evidence for direct regulation of other expressed sequences.

149 Direct regulation of other transcription factor genes li

150 part of the p53 transcriptional program and direct regulation of p53 target genes.

151 tic silenced tumor suppressor acting through direct regulation of p53 transcription and expression.

152 involved in plant defense responses, but the direct regulation of PAL genes and phenylpropanoid pathw

153 r findings establish a novel role for AP2 in direct regulation of PAR1 trafficking, a process critica

154 metabolism and suppresses metastasis through direct regulation of parallel acting transcriptional pro

155 Our results confirm the previously proposed direct regulation of Pax6 and further demonstrate that M

156 he self-renewal of muscle stem cells through direct regulation of Pax7.

157 tors, are transduced to target genes through direct regulation of PHYTOCHROME-INTERACTING FACTOR (PIF

158 IP(3) and membrane dynamics independently of direct regulation of PI3K activity and suggest that modu

159 In this study, we investigated the direct regulation of PLC-eta2 by Gbetagamma subunits of

160 Taken together, these findings reveal novel, direct regulation of PP2A activity by Galpha(12) and pot

161 These findings reveal direct regulation of PP2Ac polyubiquitination by a novel

162 s in effector tissues of this system enables direct regulation of processes (e.g. renal tubular Ca(2+

163 Direct regulation of programmed cell death may be an evo

164 responsive phosphorylation sites may reflect direct regulation of protein activity.

165 e that miR-132/212 controls cell survival by direct regulation of PTEN, FOXO3a and P300, which are al

166 component in renal Ca(2+) homeostasis under direct regulation of PTH.

167 ly binds the qseBC promoter, indicative of a direct regulation of qseBC gene transcription by PmrAB u

168 ration and differentiation, in part, through direct regulation of Rbl2 and Cdkn1a, whereas apical-bas

169 tations had profound effects consistent with direct regulation of receptor pH sensing.

170 redundantly in promoting root growth through direct regulation of redox homeostasis.

171 through the suppression of sRNA rsmZ via the direct regulation of RNase G in a biofilm-specific manne

172 n together, our results provide evidence for direct regulation of Runx2 by canonical WNT signaling an

173 ant effect on SR Ca(2+) leak rate mainly via direct regulation of RyR activity.

174 e [Ca]1/2 = 4.3 +/- 0.4 microM, suggesting a direct regulation of RyR1 function upon the calcium-depe

175 l where KLF2 regulates T cell trafficking by direct regulation of S1P(1) and CD62L and restrains spon

176 equentially control wing development through direct regulation of Ser expression in early, mid and la

177 However, the direct regulation of SHP expression may provide a basis

178 was reduced in the Slhls2 mutant suggesting direct regulation of SlBTB1 by HLS2.

179 within the SOX2 promoter, suggesting a more direct regulation of SOX2 by GLI transcription factors.

180 thylene biosynthesis and response, including direct regulation of soybean orthologs of At5g61590/MtSE

181 To define binding motifs that mediate direct regulation of splicing and polyadenylation by ESR

182 The underlying mechanism is likely the direct regulation of SR Ca2+ release channels by Casq2 r

183 Direct regulation of sRNA expression was confirmed by mu

184 cessary for VAT-Treg differentiation through direct regulation of ST2 and PPAR-gamma expression.

185 This role for HIF-1alpha demonstrates its direct regulation of survival and function in the inflam

186 out the role of M. tuberculosis molecules in direct regulation of T cell function.

187 mportant role of this innate receptor in the direct regulation of T-cell activation and survival duri

188 rovide the first molecular mechanism for the direct regulation of T-type Ca2+ channels by a protein k

189 including the hrpR promoter, suggesting the direct regulation of T3SS cascade genes by RhpR.

190 We validated the direct regulation of Tbx5 on Pcsk6 using immunohistochem

191 tive phosphorylation respectively, are under direct regulation of TCF19.

192 iption factors control BLC formation through direct regulation of Tfap2d expression.

193 Direct regulation of the activity of RGS-RhoGEFs p115 or

194 sary for adult beta-cell replication through direct regulation of the beta-cell cycle.

195 This direct regulation of the BK channel identifies a previou

196 e metabolic response to pressure overload by direct regulation of the catalytic alpha subunit of AMPK

197 Reporter assays demonstrated direct regulation of the cdc34 3'-untranslated region by

198 rylation of TRPV1 in HEK cells, suggesting a direct regulation of the channel.

199 rojection may be specialized with respect to direct regulation of the circadian clock.

200 uronal differentiation and migration through direct regulation of the Dlx1/Dlx2 bigene cluster during

201 provide the first link between an miRNA and direct regulation of the ER stress response and reveal a

202 tivating its transcription, likely through a direct regulation of the expression of several ER chaper

203 ng canonical Wnt-signaling pathway under the direct regulation of the general protein quality control

204 he ChrAS system and provide evidence for the direct regulation of the hmuO and hrtAB promoters by Chr

205 essions caused by AP-1, suggesting this is a direct regulation of the hTERT promoter.

206 HDM-induced allergic airway inflammation by direct regulation of the IFN and AhR pathways.

207 oprecipitation experiments suggested Notch-1 direct regulation of the IGF-1R promoter.

208 influences intestinal immune homeostasis via direct regulation of the IL-25-IL-23-IL-17 axis.

209 Our findings provide new insights into the direct regulation of the immune microenvironment by iris

210 MEF2A controls this process through its direct regulation of the largest known mammalian microRN

211 es using GL3:GR and TTG1:GR fusions revealed direct regulation of the late biosynthetic genes only.

212 etoglutarate, which binds to PII, was due to direct regulation of the NRII-PII interaction and the ra

213 adaptors regulate proximal T cell signaling, direct regulation of the nuclear pore complex (NPC) has

214 NF4alpha is critical for urea homeostasis by direct regulation of the OTC gene in vivo.

215 functions and show the role of IRF-5 in the direct regulation of the plasma cell commitment factor B

216 gs uncover a function for the nucleus in the direct regulation of the protein synthesis machinery via

217 This study provides insights into the direct regulation of the stability of MLL1 through its c

218 a genomic role, testosterone plays a role in direct regulation of the TRPM8 channel function.

219 g a specific number of lymphocytes caused by direct regulation of the tumor cell stiffness.

220 These results demonstrate the direct regulation of the yggX gene by the redox-sensing

221 Although mitochondria contain sphingolipids, direct regulation of their levels in mitochondria or mit

222 d, here, we describe a role for BMP8B in the direct regulation of thermogenesis.

223 munoprecipitation (ChIP) analysis revealed a direct regulation of these genes by BrlR, with DNA bindi

224 rophoretic mobility shift assays, suggesting direct regulation of these genes by Cmr.

225 This finding is consistent with direct regulation of these genes by Crz1p.

226 The direct regulation of these genes by VqsM has been confir

227 However, direct regulation of these molecular components in media

228 phases of Earth's solar day, not through the direct regulation of these processes by light and darkne

229 of a newly discovered target, we demonstrate direct regulation of this target by RyhB.

230 rols human T-cell lineage commitment through direct regulation of three distinct processes: repressio

231 ins have critical functions in biology, from direct regulation of transcription and translation to in

232 ination of the regenerative response through direct regulation of transcription factors involved in e

233 reprogramming of gene expression through the direct regulation of transcription factors or through th

234 H(2)O(2)-induced SOD-2 expression through a direct regulation of transcription mediated by activatin

235 ding proteins that has been involved in both direct regulation of transporter activity (inducer exclu

236 These data provide evidence for direct regulation of triglyceride turnover by a peripher

237 This is the first example of direct regulation of TRP channel function through tyrosi

238 suggest the role of estrogen metabolism in a direct regulation of TRPA1 activity with potential impli

239 ol over microtubules in cells occurs through direct regulation of tubulin or indirectly through the p

240 effects on color pattern development through direct regulation of unlinked "modifier" genes.

241 uria in CasR-deficient mice, consistent with direct regulation of urinary calcium excretion by CasR i

242 Although there are limited examples of direct regulation of virulence factors, PASTA kinases ar

243 s a central role in bile acid conjugation by direct regulation of VLACSR and BAT in vivo.

244 , VGLL1 enhanced canonical WNT signaling via direct regulation of WNT receptors and effectors.

245 Our results also suggested that miR160-directed regulation of auxin response factors (ARFs) con

246 tant molecular mediator of this Schwann cell-directed regulation of cancer cells in perineural invasi

247 These results demonstrate that miR164-directed regulation of CUC1 is necessary for normal embr

248 the design of transcription factors for the directed regulation of endogenous genes.

249 ides the basis for a mechanism of superoxide-directed regulation of eNOS, involving thiol oxidation,

250 RNA-directed regulation of epigenetic processes has recently

251 of the most powerful new approaches for the directed regulation of gene expression uses the phenomen

252 ranscriptional reprograming, in which EIN2-C-directed regulation of histone acetylation is the first

253 In addition to identifying a case of RNA-directed regulation of miRNA biogenesis, our study revea

254 we identify a developmental role for miR164-directed regulation of NAC-domain genes, which encode a

255 Thus, cGMP-directed regulation of PDE5 phosphorylation and the resu

256 t of editing levels, suggesting stronger cis-directed regulation of RNA editing for most sites, altho

257 providing auxiliary evidence for Wee kinase-directed regulation of the chromatin regulator Stonewall

258 se results reveal that a differential 5' UTR-directed regulation of translation can occur in coronavi

259 a, p101/p110gamma and p84/p110gamma, receive direct regulation through Gbetagamma or indirect regulat

260 ed polymerase does not necessarily equate to direct regulation through pause release to productive el

261 We discovered that Stat3 imposes self-directed regulation through controlling transcription of

262 han inhibiting other regulations, and adding direct regulations to a drug-target generally reduces it

263 Direct regulation via the Sin3 subunit coordinates bindi

264 To demonstrate direct regulation, we performed band shift and footprint