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1 r genome is 46,214 bp with a 237 bp terminal direct repeat.
2 the 10 loci contained exact integers of the direct repeat.
3 vealed a tandem PhoP dimer that bound to the direct repeat.
4 occurred at position 6488 generating a 3 bp direct repeat.
5 egion flanked at each terminus by a sizeable direct repeat.
6 lpha binding element (EBE) consists of three direct repeats.
7 two GATA-binding motifs and three octameric direct repeats.
8 typically consist of a tandem arrangement of direct repeats.
9 l peptides, conserved cysteine positions and direct repeats.
10 instability of DNA segments flanked by short direct repeats.
11 mino-acid (aa) direct repeats, and two 88-aa direct repeats.
12 scription by binding in tandem to target DNA direct repeats.
13 displays a 4977-bp deletion flanked by short direct repeats.
14 containing small palindromes embedded within direct repeats.
15 ying genes of unknown function surrounded by direct repeats.
16 and most of these elements are organized as direct repeats.
17 p single deletion in mtDNA, without flanking direct repeats.
18 degree of specificity is associated with the direct repeats.
19 t to a series of non-homologous short (6 bp) direct repeats.
20 flanked on either side by 3.73-kb identical direct repeats.
21 te is located) adjacent to a series of short direct repeats.
22 rspersed repeats that bear both inverted and direct repeats.
23 from cut sites within, or adjacent to, short direct repeats.
24 e half sites that constitute the overlapping direct repeat 1 (DR1) and direct repeat 2 (DR2) motifs a
25 templates for these template switches, with direct repeat 1 (DR1) and DR2 for primer translocation a
30 tes proopiomelanocortin through binding of a direct repeat 1 response element in the promoter, and th
31 y shift assay shows that TR4 can bind to the direct repeat 1 sequence element (AGGTTAAAGGTCT, nucleot
32 initiate plus-strand DNA synthesis from the direct repeat 2 (DR2) located near the opposite end of t
33 te the overlapping direct repeat 1 (DR1) and direct repeat 2 (DR2) motifs and two forkhead factor bin
34 DNA, most of which is in close proximity to direct repeat 2 (DR2); (iii) DP-rcDNA exhibits an RNA pr
35 omni immunoglobulin-binding protein A (IbpA) direct repeat 2 Fic domain (DR2/Fic) for natural host ta
38 ated by a 4-nucleotide spacer similar to the direct repeat 4 element and is designated as a putative
41 X receptor (RXR) or CAR-RXR heterodimers to direct repeat-4 type nuclear receptor-binding sites foun
43 e mature dorsal spinal cord, expression of a direct repeat 5 RA response element (DR5-RARE) transgene
44 site (TSS) identified 3 conserved hexameric direct repeat-5 elements, RARE1, -2 and -3, and a half s
45 w that the transposon is flanked by an 18-bp direct repeat, a copy of which is also present at the ta
46 efore these deletions, were flanked by short direct repeats, a unique signature of intrachromosomal i
48 xclusively A+T-containing segment, five 9-bp direct repeats, an inverted repeat, and a sigma(A)-depen
49 we created plasmid x chromosome, chromosomal direct repeat and allelic recombination substrates in wh
51 NA packaging (pac) site containing two 21-bp direct repeats and a major terminase cleavage site in th
53 mes is due primarily to the transposition of direct repeats and insertion sequence (IS) elements.
56 surrounding the deletion contained two 4-bp direct repeats and that a hairpin structure could be for
57 motifs, inverted repeats, mirror repeats and direct repeats and their associated subsets of cruciform
58 ents can insert into genes as closely spaced direct repeats and they frequently undergo incomplete ex
60 Comparative analysis suggests that a short direct repeat, and a secondary structure including the t
61 R) as scored using a reporter that harbors a direct repeat, and are prone to gross chromosomal rearra
62 ovar Typhimurium strain LT2 was analyzed for direct repeats, and 54 sequences containing variable-num
65 ng elements are flanked by either 8- or 9-bp direct repeats, and they differ significantly in size co
67 imilarity); (ii) a central domain containing direct repeats; and (iii) a C-terminal domain that is si
68 erminal inverted repeats, usually flanked by direct repeats; and compared IS-interrupted sequences wi
69 ides an explanation of why both inverted and direct repeats are maintained and how they contribute to
71 s accommodate simultaneous binding of Int to direct-repeat arm sites and indirect-repeat core sites a
72 by recombinational events between nontandem direct repeats as short as 8 bases, and (iii) substituti
74 etion inactivated lpr0035, removed the 49-bp direct repeat at the 5' junction of pLP45, and locked pL
75 us type 1 (HSV-1) a sequence is present as a direct repeat at the two termini of the 152-kilobase vir
78 correspondence to the position of two 13-bp direct repeats beginning at nucleotides 8470 and 13 447.
80 ions, each comprised of a novel set of three direct-repeat binding sites spaced 21 bp apart on center
82 deleted, binding was still specific for the direct repeat but was much weaker and appeared to requir
84 with cell source) GC-rich copies of a 102-bp direct repeat (called IR 4) flanked by small unique sequ
85 We show here that transgenes with intrinsic direct repeats can also induce PTGS at a very high frequ
88 pes can amplify by unequal exchanges between direct repeats (CD), and both are rare in unselected cul
89 ses its own CRISPR array with short and long direct repeats, cleaves target RNA, and exhibits collate
90 ions, we regularly detected the formation of direct repeats close to the break sites, independent of
91 lA box is 17 nucleotides long and contains a direct repeat comprised of two hexamers separated by 5 n
92 t tcpA, two toxbox elements are present in a direct repeat configuration and both are required for ac
93 ntly, when the RFB is positioned between the direct repeat, conservative gene conversion events predo
95 strated that COUP-TFII binds to an imperfect direct repeat COUP-TFII recognition sequence (termed her
96 ne conversion and increased both spontaneous direct repeat deletion and spontaneous allelic conversio
97 in vivo trans-complementation assay in which direct repeat deletion through template switching recons
99 cant association of the endpoints with short direct repeats, despite the fact that several such repea
103 s target genes containing two hexanucleotide direct repeat DNA-response elements separated by one bas
107 nonical inverted repeat was converted into a direct repeat (DR) via large-scale inversion in some Sel
108 CARs are inactive on classical CAR-inducible direct repeat (DR)-4 elements, yet efficiently transacti
111 evious report has identified a non-consensus direct repeat (DR-1) element in the RXRgamma2 gene promo
114 lavivirus genome also contain distinct short direct repeats (DRs), such as RCS3, CS3, RCS2, and CS2.
115 five Rep monomers bind five tetranucleotide direct repeats; each repeat is recognized by two Rep mon
116 definitive, a protein complex that binds to direct repeat elements in the embryonic and fetal beta-t
117 4) were previously shown to bind in vitro to direct repeat elements in the mouse and human embryonic
118 of 220- to 390-nucleotide degenerate tandem direct repeats encoding putative DNA binding proteins.
119 r receptors comprise the DNA-binding core of direct repeat erythroid definitive, a protein complex th
123 eparated by a coupling sequence derived from direct repeats flanking chromosomal copies of ICEF as a
125 s reports, several of these Ds elements lack direct repeats flanking the deletion junctions and fille
126 -related integration and excision genes, and direct repeats flanking the island, suggest it moves as
129 rm reveals the loss of three of 10 imperfect direct repeats from the central region of the lumenal do
130 ind that pre-crRNAs comprising a full-length direct repeat (full-DR-crRNA) sequence with specific ste
133 aliana, was previously shown to contain four direct repeats (Gap boxes, located between -237 and -181
135 ssion of ATPase(-) Rad54 reduced spontaneous direct repeat gene conversion and increased both spontan
136 ing HeLa cell lines harbouring an integrated direct repeat green fluorescent protein reporter for DSB
137 at ComE protects sequences inclusive of both direct repeats, has an equilibrium dissociation constant
139 e, consisting of two motifs of two imperfect direct repeat hexamers spaced by four nucleotides and a
140 nting analysis that includes three imperfect direct repeat hexamers that are needed for full occupanc
145 NA-PKcs on DSB-induced HR, we integrated neo direct repeat HR substrates carrying the I-SceI recognit
149 gested that purified ComE binds to two 11-bp direct repeats in the nlmC-comC promoter region, where C
150 ed by DNase I protection assays to a pair of direct repeats in the P2 and P3 promoter regions of the
151 ntly as a monomer to each toxbox in the tcpA direct repeat, in accordance with what we observed previ
152 ISs and their sequence elements-inverted and direct repeats-in raw read data or contigs using flexibl
153 The deleted region, which is flanked by two direct repeats, includes three exons of STX16, the gene
154 ound in the database were flanked by 9-14 bp direct repeats, indicating that their transposition was
156 oreover, we determined that a minimum of two direct repeats is required to form a stable complex and
157 al sequence composed of four 12-bp imperfect direct repeats (iterons) in the pBtoxis minireplicon was
164 s in increased mitochondrial frameshifts and direct-repeat mediated deletions but has no effect on th
165 r the first time in mammalian cells, a short direct repeat-mediated noncanonical splicing event induc
166 system to simultaneously monitor spontaneous direct-repeat-mediated deletions (DRMDs) in the nuclear
167 enetic reporter to measure the rate at which direct-repeat-mediated deletions arise in the mitochondr
168 which these deletions arise is unknown, but direct-repeat-mediated deletions involving polymerase sl
170 recombination (HR; using fluorescent yellow direct repeat mice), and transcript levels for several r
171 HR in vivo, we have used fluorescent yellow direct repeat mice, in which an HR event at a transgene
175 es, Xenopus treacle has 11 highly homologous direct repeats near the center of the protein molecule s
176 ected region of 26 to 28 bp encompassing two direct repeats, NTTAAG-n5-WTTAAG, 10 bp upstream of the
178 he ATPA regulatory element 1 is an imperfect direct repeat of a nuclear receptor response element (A/
181 9 proviruses analyzed were flanked by a 6-bp direct repeat of host sequences, as is characteristic fo
184 odimer, BR-Base-a1-Acid-a1-BR, can bind to a direct repeat of the GCN4 half-site in vivo, leading to
186 proximal portion of the enhancer contains a direct repeat of two E-Box motifs, which contributes mos
187 A functional retinoic acid response element direct repeat of two novel motifs separated by a 5-bp sp
193 ons are situated within tandem or non-tandem direct repeats of at least 5-bp and may be explained by
194 g analysis revealed that MtrA recognizes two direct repeats of GTCACAgcg-like sequences and that MtrA
196 show acts with high efficiency via terminal direct repeats of only 28 bp and with reduced but measur
197 containing the inverted repeat of pAM373 and direct repeats of pAD1 was mobilized efficiently by pAD1
198 silencing induced by a transgene with three direct repeats of the beta-glucuronidase (GUS) open read
200 strong TRE consisting of two nearly perfect direct repeats of the consensus nuclear hormone receptor
201 ulated genes have defined canonical RAREs as direct repeats of the consensus RGKTCA separated by 1, 2
205 splicing factor composed almost entirely of direct repeats of the tetratricopeptide repeat (TPR) pro
206 opy F'(128) plasmid, where lac is flanked by direct repeats of the transposable element IS3 (1258 bp)
208 ty in either assay, either by removal of the direct repeat or by mutation of RAD52, increased the rel
210 s a pair of ToxT binding sites arranged in a direct repeat orientation upstream of the core promoter
213 usly, one MDS and its outgoing (3') pointer (direct repeat) overlap intron splice sites, indicating t
214 Inverse repeat p53REs favor the H14 mode and direct repeat p53REs may have high possibilities of othe
215 c switch, including PhoP with its associated directed repeat PHO box, candidate motifs for two SARPs,
216 ansversions affecting nucleotides within two direct repeats present in the TcpP-binding region (TGTAA
218 o1 promotes replication fork barrier-induced direct repeat recombination but intriguingly limits reco
219 mologue Rqh1 for DNA repair and promotion of direct repeat recombination in the fission yeast Schizos
220 lays a major role in limiting Exo1-dependent direct repeat recombination induced by replication fork
222 ly unstable and is lost at high frequency by direct repeat recombination involving the loop sequence.
226 ral genome with a single fully reconstituted direct repeat region (DR) with both terminal cleavage an
227 pacers" separating insertion elements in the direct repeat region of the M. tuberculosis genome.
228 tion may be possible through the inverted or direct repeat regions, while horizontal gene transfer se
229 One mutation defined a cis-acting adjacent direct repeat required for optimal spxB transcription.
231 lindrome separated by 17 bases) and DR-11 (a direct repeat separated by 11 bases) in the 5'-flanking
232 hormone receptor-binding hexad arranged as a direct repeat separated by one nucleotide (DR-1) in the
233 trated that FsrA also binds to two imperfect direct repeats separated by 13 bp, based on the consensu
234 r, conversion frequencies were identical for direct repeats separated by 3800 bp of transcriptionally
235 se proteins generally binds to two imperfect direct repeats separated by a number of bases that place
236 tection region in the P1 promoter contains a direct repeat sequence (GTTAAN(6)GTTAA [where N is any n
237 btr is relieved and Btr binds to a conserved direct repeat sequence adjacent to feuA to activate tran
238 sults, we concluded that SaeR recognizes the direct repeat sequence as a binding site and that bindin
239 DMD methylation is in turn controlled by a direct repeat sequence immediately downstream of the DMD
240 The data also demonstrate that deletion of a direct-repeat sequence restricts the mobility of pLP45 a
243 interaction of TcpP with nucleotides of the direct repeat sequences appears to be a prerequisite for
245 on of a double-strand break (DSB) flanked by direct repeat sequences is mediated by single-strand ann
246 s specifically to dsDNA containing the oriT2 direct repeat sequences, confirming their role in transf
247 a short stretches [5-20 nucleotides (nt)] of direct repeat sequences, yielding deletions of interveni
248 ia single-strand annealing of short terminal direct repeats showed substantially higher repair effici
249 rization thus drive Hap1 selectivity for CGG direct repeat sites that contain an asymmetrically posit
250 n many aspects, e.g., having TIR signals and direct repeats, small in size, noncoding, able to fold i
251 ity factor binds in vitro to three imperfect direct repeats, spaced 10 base pairs apart, in a sequent
252 tescibacteria LexA-binding motif has unusual direct-repeat structure, and comparative analyses reveal
253 the saddle-shaped TBP molecule, with its two direct-repeat subdomains and pseudo-two-fold symmetry.
255 entical inverted repeats and enclosed within direct repeats, suggesting that these genetic regions mi
256 ases) genomes, that have similarly extensive direct repeats, suggests that recombination between such
259 wo GATA motifs in palindromic (Pal-GATA) and direct-repeat (Tandem-GATA) arrangements, respectively,
261 of these regions revealed two sets of a TCT direct repeat [TCT-N8-TCT] present at positions (-107 to
262 s terminal inverted repeats (TIRs), terminal direct repeats (TDRs), and interspersed repeats that bea
265 mutations are associated with palindromic or direct repeats that are either perfect or imperfect.
268 ers P(RE), P(I), and P(AQ) by binding to two direct repeats that flank the promoter -35 element.
269 donor DNA, deletions of up to 5 kb involving direct repeats that flank the psbA gene were obtained.
271 results in instability of sequences between direct repeats that is dependent on transcription of the
272 by site-specific recombination within 60 bp direct repeats that mark the junctions between ICEBs1 an
274 rains lacked the missing DNA between the two direct repeats that was found in all large ascospore-der
278 oters contain a common regulatory element, a direct repeat typical of OmpR-class transcription factor
281 r and that phosphorylated HssR binds to this direct repeat upon exposure of S. aureus to high concent
284 tinylated oligoribonucleotide containing the direct repeat was used as an affinity ligand to purify t
285 recent study, the abundant presence of short direct repeats was documented by comparative bioinformat
286 tion between long CTG.CAG tracts oriented as direct repeats was extraordinarily high; recombinants we
287 d by bacteriophage P1 loxP sites oriented as direct repeats was inserted within a selected gene.
289 he delivered DNA, and inverted and imperfect direct repeats were detected in the same transgene locus
293 The P1 phage loxP sites are identical 34-bp direct repeats, whereas the phiC31 phage attB/attP sites
294 of (i) a variable region containing multiple direct repeats which differ in number and sequence from
295 ent PXR DNA-binding motif is the AGTTCA-like direct repeat with a 4 bp spacer [direct repeat (DR)-4)]
296 bsite appears to be oriented as an imperfect direct repeat with its adjacent subsite, although base s
297 heritability, we propose that the intrinsic direct repeat within a transgene may act as a primary de
298 iations resulting from loss or gain of long, direct repeats within the protein coding sequences.
299 in an 11.3-kb segment of DNA flanked by 7-bp direct repeats within the serotype 4 strain which is not
300 iously showed that CpG-rich imperfect tandem direct repeats within three different mouse DMDs (Snurf/